MONDO:0004948 |
ATM |
Q13315 |
2.7.11.1
|
R-HSA-2559586
R-HSA-2559586
Reactome Name: DNA Damage/Telomere Stress Induced Senescence
See in Reactome
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-9664873
R-HSA-69473
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-69541
R-HSA-6803207
R-HSA-6803207
Reactome Name: TP53 Regulates Transcription of Caspase Activators and Caspases
See in Reactome
R-HSA-6803204
R-HSA-6803204
Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5693548
R-HSA-5693548
Reactome Name: Sensing of DNA Double Strand Breaks
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-912446
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-2559583
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-1640170
R-HSA-8953897
R-HSA-73857
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-5633007
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-5633008
R-HSA-5633008
Reactome Name: TP53 Regulates Transcription of Cell Death Genes
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-5693538
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-1474165
R-HSA-9612973
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-9663891
R-HSA-1632852
R-HSA-69481
R-HSA-69615
R-HSA-1500620
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
|
Cell Cycle
Cellular responses to stimuli
Gene expression (Transcription)
Reproduction
Autophagy
DNA Repair
|
R-HSA-3371567
(
R-HSA-3371453
)
R-HSA-3371567
Reaction Name: DBC1 is phosphorylated by ATM/ART
See in Reactome
R-HSA-349444
(
R-HSA-349425;
R-HSA-69541
)
R-HSA-349444
Reaction Name: Phosphorylation of COP1 at Ser-387 by ATM
See in Reactome
R-HSA-349455
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-5682018
(
R-HSA-2559586
)
R-HSA-5682018
Reaction Name: MRN complex bound to shortened telomeres recruits ATM
See in Reactome
R-HSA-5682026
(
R-HSA-2559586
)
R-HSA-5682026
Reaction Name: MRN bound to shortened telomeres activates ATM
See in Reactome
R-HSA-5682044
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5682044
Reaction Name: KAT5 acetylates ATM at DNA DSBs
See in Reactome
R-HSA-5682586
(
R-HSA-5693565
)
R-HSA-5682586
Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs
See in Reactome
R-HSA-5682588
(
R-HSA-5693565
)
R-HSA-5682588
Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs
See in Reactome
R-HSA-5682598
(
R-HSA-5693565
)
R-HSA-5682607
(
R-HSA-5693565
)
R-HSA-5682607
Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
See in Reactome
R-HSA-5682629
(
R-HSA-5693565
)
R-HSA-5682629
Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
See in Reactome
R-HSA-5682858
(
R-HSA-5693565
)
R-HSA-5682858
Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX
See in Reactome
R-HSA-5682863
(
R-HSA-5693565
)
R-HSA-5682965
(
R-HSA-5693565
)
R-HSA-5682965
Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs
See in Reactome
R-HSA-5682967
(
R-HSA-5693565
)
R-HSA-5682983
(
R-HSA-5693565
)
R-HSA-5682992
(
R-HSA-5693565
)
R-HSA-5683077
(
R-HSA-5693565
)
R-HSA-5683077
Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B
See in Reactome
R-HSA-5683384
(
R-HSA-5693565
)
R-HSA-5683384
Reaction Name: UIMC1 and FAM175A bind DNA DSBs
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683405
(
R-HSA-5693565
)
R-HSA-5683405
Reaction Name: PPP5C dephosphorylates TP53BP1
See in Reactome
R-HSA-5683425
(
R-HSA-5693565
)
R-HSA-5683425
Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
R-HSA-5683986
(
R-HSA-5693565
)
R-HSA-5683986
Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX
See in Reactome
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684081
(
R-HSA-5693607
)
R-HSA-5684081
Reaction Name: MRN complex binds CDK2 and RBBP8
See in Reactome
R-HSA-5684096
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684140
(
R-HSA-5693607
)
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686578
(
R-HSA-5693565
)
R-HSA-5686578
Reaction Name: Activated ATM phosphorylates ABL1
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5686704
(
R-HSA-5693571
)
R-HSA-5686704
Reaction Name: Activated ATM phosphorylates DCLRE1C
See in Reactome
R-HSA-5686900
(
R-HSA-5693571
)
R-HSA-5686900
Reaction Name: TP53BP1 recruits DCLRE1C to ATM
See in Reactome
R-HSA-5693536
(
R-HSA-5693565
)
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693540
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693549
(
R-HSA-5693565
)
R-HSA-5693549
Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693566
(
R-HSA-5693565
)
R-HSA-5693566
Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693583
(
R-HSA-5693565
)
R-HSA-5693583
Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693598
(
R-HSA-5693565
)
R-HSA-5693599
(
R-HSA-5693571
)
R-HSA-5693599
Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break
See in Reactome
R-HSA-5693602
(
R-HSA-5693565
)
R-HSA-5693602
Reaction Name: ATM recognizes H2AFX-Nucleosomes
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693609
(
R-HSA-2559586;
R-HSA-5693565;
R-HSA-6804756;
R-HSA-69541
)
R-HSA-5693609
Reaction Name: ATM phosphorylates TP53 at S15
See in Reactome
R-HSA-5693612
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693612
Reaction Name: MRN complex bound to DNA ends recruits ATM
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6792712
(
R-HSA-2559586
)
R-HSA-6792712
Reaction Name: KAT5 acetylates ATM at shortened telomeres
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6798372
(
R-HSA-6804756
)
R-HSA-6799097
(
R-HSA-6803204
)
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-6800490
(
R-HSA-6803207
)
R-HSA-6804276
(
R-HSA-6804760
)
R-HSA-6804741
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-6804741
Reaction Name: MDM2 forms homo- or heterodimers
See in Reactome
R-HSA-6804955
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-912429
(
R-HSA-912446
)
R-HSA-912429
Reaction Name: Resolution of meiotic holliday junction
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912496
(
R-HSA-912446
)
R-HSA-912496
Reaction Name: Formation of meiotic holliday junction
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9664850
(
R-HSA-9664873
)
R-HSA-9664855
(
R-HSA-9664873
)
R-HSA-9664855
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664862
(
R-HSA-9664873
)
R-HSA-9664862
Reaction Name: ATM dimer:PEX5 phosphorylates PEX5
See in Reactome
R-HSA-9664879
(
R-HSA-9664873
)
R-HSA-9664880
(
R-HSA-9664873
)
R-HSA-9664880
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1
See in Reactome
R-HSA-9664881
(
R-HSA-9664873
)
R-HSA-9664881
Reaction Name: NBR1 binds ATM:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664883
(
R-HSA-9664873
)
R-HSA-9664883
Reaction Name: ATM:PEX5 translocates from cytosol to peroxisomal membrane
See in Reactome
R-HSA-9664888
(
R-HSA-9664873
)
R-HSA-9664888
Reaction Name: ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9664892
(
R-HSA-9664873
)
R-HSA-9664892
Reaction Name: SQSTM1 binds ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674127
(
R-HSA-9664873
)
R-HSA-9674127
Reaction Name: USP30 deubiquitinates ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674131
(
R-HSA-9664873
)
R-HSA-9674131
Reaction Name: USP30 binds ATM dimer:Ub-p-PEX5
See in Reactome
|
MONDO:0008393 |
CREBBP |
Q92793 |
2.3.1.-
2.3.1.48
|
R-HSA-9617629
R-HSA-9617629
Reactome Name: Regulation of FOXO transcriptional activity by acetylation
See in Reactome
R-HSA-210744
R-HSA-210744
Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
See in Reactome
R-HSA-381340
R-HSA-381340
Reactome Name: Transcriptional regulation of white adipocyte differentiation
See in Reactome
R-HSA-8939246
R-HSA-8939246
Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
See in Reactome
R-HSA-9013695
R-HSA-9013695
Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription
See in Reactome
R-HSA-2151201
R-HSA-2151201
Reactome Name: Transcriptional activation of mitochondrial biogenesis
See in Reactome
R-HSA-8941856
R-HSA-8941856
Reactome Name: RUNX3 regulates NOTCH signaling
See in Reactome
R-HSA-350054
R-HSA-350054
Reactome Name: Notch-HLH transcription pathway
See in Reactome
R-HSA-1989781
R-HSA-1989781
Reactome Name: PPARA activates gene expression
See in Reactome
R-HSA-9018519
R-HSA-9018519
Reactome Name: Estrogen-dependent gene expression
See in Reactome
R-HSA-918233
R-HSA-918233
Reactome Name: TRAF3-dependent IRF activation pathway
See in Reactome
R-HSA-400206
R-HSA-400206
Reactome Name: Regulation of lipid metabolism by PPARalpha
See in Reactome
R-HSA-2426168
R-HSA-2426168
Reactome Name: Activation of gene expression by SREBF (SREBP)
See in Reactome
R-HSA-9013508
R-HSA-9013508
Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription
See in Reactome
R-HSA-3214847
R-HSA-3371568
R-HSA-8866907
R-HSA-8866907
Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors
See in Reactome
R-HSA-6803204
R-HSA-6803204
Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
See in Reactome
R-HSA-9614657
R-HSA-9614657
Reactome Name: FOXO-mediated transcription of cell death genes
See in Reactome
R-HSA-933541
R-HSA-1234158
R-HSA-1234158
Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor
See in Reactome
R-HSA-1368082
R-HSA-1368082
Reactome Name: RORA activates gene expression
See in Reactome
R-HSA-5617472
R-HSA-5617472
Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis
See in Reactome
R-HSA-3899300
R-HSA-3899300
Reactome Name: SUMOylation of transcription cofactors
See in Reactome
R-HSA-2122947
R-HSA-2122947
Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription
See in Reactome
R-HSA-1368108
R-HSA-1368108
Reactome Name: BMAL1:CLOCK,NPAS2 activates circadian gene expression
See in Reactome
R-HSA-400253
R-HSA-9707616
R-HSA-3134973
R-HSA-3134973
Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
See in Reactome
R-HSA-201722
R-HSA-201722
Reactome Name: Formation of the beta-catenin:TCF transactivating complex
See in Reactome
R-HSA-1912408
R-HSA-1912408
Reactome Name: Pre-NOTCH Transcription and Translation
See in Reactome
R-HSA-5621575
R-HSA-9707564
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9012852
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-168256
R-HSA-157118
R-HSA-1592230
R-HSA-1430728
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5633008
R-HSA-5633008
Reactome Name: TP53 Regulates Transcription of Cell Death Genes
See in Reactome
R-HSA-8864260
R-HSA-8864260
Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-1852241
R-HSA-1852241
Reactome Name: Organelle biogenesis and maintenance
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-2990846
R-HSA-556833
R-HSA-8957322
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-8953897
R-HSA-5619507
R-HSA-5619507
Reactome Name: Activation of HOX genes during differentiation
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-1234174
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-195721
R-HSA-8939211
R-HSA-9711123
R-HSA-9711123
Reactome Name: Cellular response to chemical stress
See in Reactome
R-HSA-1912422
R-HSA-1912422
Reactome Name: Pre-NOTCH Expression and Processing
See in Reactome
R-HSA-9013694
R-HSA-3247509
R-HSA-1980143
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-9614085
R-HSA-1655829
R-HSA-1655829
Reactome Name: Regulation of cholesterol biosynthesis by SREBP (SREBF)
See in Reactome
R-HSA-3108232
R-HSA-3108232
Reactome Name: SUMO E3 ligases SUMOylate target proteins
See in Reactome
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-4839726
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-2262752
R-HSA-162582
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
|
Circadian Clock
Immune System
Metabolism
Developmental Biology
Gene expression (Transcription)
Organelle biogenesis and maintenance
Cellular responses to stimuli
Metabolism of proteins
Chromatin organization
Signal Transduction
|
R-HSA-1989746
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-9761836
()
R-HSA-9761836
Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300
See in Reactome
R-HSA-560491
(
R-HSA-381340
)
R-HSA-1989756
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1989754
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-4396371
(
R-HSA-2122947
)
R-HSA-4396371
Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter
See in Reactome
R-HSA-9038052
(
R-HSA-9018519
)
R-HSA-9038052
Reaction Name: GREB1 binds ESR1:ESTG and co-activators
See in Reactome
R-HSA-1234167
(
R-HSA-1234158
)
R-HSA-1234167
Reaction Name: Formation of HIF:CBP:p300 complex at promoters
See in Reactome
R-HSA-9617758
(
R-HSA-9617629
)
R-HSA-9016751
(
R-HSA-9013508
)
R-HSA-9016751
Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3
See in Reactome
R-HSA-560498
(
R-HSA-381340
)
R-HSA-560498
Reaction Name: Expression of Lipoprotein lipase (LPL)
See in Reactome
R-HSA-1980065
(
R-HSA-2122947
)
R-HSA-1980065
Reaction Name: NOTCH1 stimulates HEY transcription
See in Reactome
R-HSA-9759332
()
R-HSA-9759332
Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter
See in Reactome
R-HSA-1989755
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1980067
(
R-HSA-2122947
)
R-HSA-1980067
Reaction Name: NOTCH1 stimulates MYC transcription
See in Reactome
R-HSA-9761849
()
R-HSA-9761849
Reaction Name: AcK-NFE2L2-dependent P6GD gene expression
See in Reactome
R-HSA-1183003
(
R-HSA-381340
)
R-HSA-3134883
(
R-HSA-3134973
)
R-HSA-3134883
Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300
See in Reactome
R-HSA-381309
(
R-HSA-381340
)
R-HSA-381309
Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands
See in Reactome
R-HSA-1028820
(
R-HSA-933541
)
R-HSA-1028820
Reaction Name: Formation of VAF (virus-activated factor) complex
See in Reactome
R-HSA-8878243
(
R-HSA-8941856
)
R-HSA-8878243
Reaction Name: HES1 gene transcription is inhibited by RUNX3
See in Reactome
R-HSA-1989753
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-9021450
(
R-HSA-9013508
)
R-HSA-9021450
Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes
See in Reactome
R-HSA-9761828
()
R-HSA-8938231
(
R-HSA-8939246
)
R-HSA-1028817
(
R-HSA-918233
)
R-HSA-1028817
Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3
See in Reactome
R-HSA-400143
(
R-HSA-400206;
R-HSA-9707564
)
R-HSA-400143
Reaction Name: Fatty acid ligands activate PPARA
See in Reactome
R-HSA-9761846
()
R-HSA-9761846
Reaction Name: NFE2L2-dependent PGD gene expression
See in Reactome
R-HSA-4396347
(
R-HSA-2122947;
R-HSA-8941856
)
R-HSA-4396347
Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter
See in Reactome
R-HSA-9759141
()
R-HSA-9759141
Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene
See in Reactome
R-HSA-9760125
()
R-HSA-9760125
Reaction Name: AcK-NFE2L2-dependent GCLM gene expression
See in Reactome
R-HSA-1592238
(
R-HSA-1989781;
R-HSA-2151201;
R-HSA-400206
)
R-HSA-1989751
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1989777
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-560473
(
R-HSA-1989781;
R-HSA-381340;
R-HSA-400206
)
R-HSA-9622604
(
R-HSA-9614657
)
R-HSA-9622604
Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y
See in Reactome
R-HSA-3371554
(
R-HSA-3371568
)
R-HSA-1989745
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-9017835
(
R-HSA-1912408
)
R-HSA-9017835
Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene
See in Reactome
R-HSA-1989772
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1989771
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1655850
(
R-HSA-1989781;
R-HSA-2426168;
R-HSA-400206
)
R-HSA-1655850
Reaction Name: Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase)
See in Reactome
R-HSA-3927959
(
R-HSA-3899300
)
R-HSA-3927959
Reaction Name: SUMOylation of CREBBP with SUMO1
See in Reactome
R-HSA-1801587
(
R-HSA-1368082;
R-HSA-1989781;
R-HSA-400206;
R-HSA-400253
)
R-HSA-9761812
()
R-HSA-9761812
Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD
See in Reactome
R-HSA-4396382
(
R-HSA-2122947
)
R-HSA-4396382
Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes
See in Reactome
R-HSA-560510
(
R-HSA-381340
)
R-HSA-9760097
()
R-HSA-9760097
Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene
See in Reactome
R-HSA-212356
(
R-HSA-350054
)
R-HSA-212356
Reaction Name: Formation of CSL-NICD coactivator complex
See in Reactome
R-HSA-879724
(
R-HSA-1368108;
R-HSA-1989781;
R-HSA-400206;
R-HSA-400253
)
R-HSA-1980047
(
R-HSA-210744;
R-HSA-2122947;
R-HSA-8941856
)
R-HSA-1980047
Reaction Name: NOTCH1 stimulates HES1 transcription
See in Reactome
R-HSA-9626945
(
R-HSA-9617629
)
R-HSA-1235037
(
R-HSA-1234158
)
R-HSA-8878237
(
R-HSA-8941856
)
R-HSA-8878237
Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter
See in Reactome
R-HSA-9622579
(
R-HSA-9614657
)
R-HSA-9622579
Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter
See in Reactome
R-HSA-933536
(
R-HSA-933541
)
R-HSA-933536
Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300
See in Reactome
R-HSA-6798004
(
R-HSA-6803204
)
R-HSA-6798004
Reaction Name: TP53 stimulates BNIP3L expression
See in Reactome
R-HSA-9760128
()
R-HSA-9760128
Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression
See in Reactome
R-HSA-9617683
(
R-HSA-9617629
)
R-HSA-9617683
Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4
See in Reactome
R-HSA-1912415
(
R-HSA-1912408
)
R-HSA-1028812
(
R-HSA-918233
)
R-HSA-1989773
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-9760082
()
R-HSA-1912394
(
R-HSA-2122947
)
R-HSA-1912394
Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML
See in Reactome
R-HSA-560493
(
R-HSA-381340
)
R-HSA-8938228
(
R-HSA-8939246
)
R-HSA-8938228
Reaction Name: RUNX1:CBFB:CREBBP binds the CSF2 (GM-CSF) gene promoter
See in Reactome
R-HSA-1989765
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-560517
(
R-HSA-1989781;
R-HSA-381340;
R-HSA-400206
)
R-HSA-560517
Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT)
See in Reactome
R-HSA-1912393
(
R-HSA-2122947
)
R-HSA-1912393
Reaction Name: MAML in complex with NICD1 recruits CDK8
See in Reactome
R-HSA-1989764
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1989758
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1028819
(
R-HSA-933541
)
R-HSA-1028819
Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes
See in Reactome
R-HSA-5660666
(
R-HSA-5621575
)
R-HSA-5660666
Reaction Name: CBP and p300 binds NF-kB complex
See in Reactome
R-HSA-1912416
(
R-HSA-1912408
)
R-HSA-1989750
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1912391
(
R-HSA-2122947
)
R-HSA-1912391
Reaction Name: NICD1 is phosphorylated by CDK8
See in Reactome
R-HSA-9761815
()
R-HSA-9761815
Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene
See in Reactome
R-HSA-9760122
()
R-HSA-9760122
Reaction Name: AcK-NFE2L2-dependent GCLC gene expression
See in Reactome
R-HSA-1989775
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1235035
(
R-HSA-1234158
)
R-HSA-1235035
Reaction Name: Expression of Carbonic Anhydrase IX (CA9)
See in Reactome
R-HSA-9021451
(
R-HSA-9013508
)
R-HSA-9021451
Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter
See in Reactome
R-HSA-1989747
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1989776
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-8864307
(
R-HSA-8866907
)
R-HSA-8864307
Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP
See in Reactome
R-HSA-1028815
(
R-HSA-918233
)
R-HSA-1028815
Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta
See in Reactome
R-HSA-3697008
(
R-HSA-3214847
)
R-HSA-3697008
Reaction Name: CREBBP acetylates histone H2B, H3, H4
See in Reactome
R-HSA-1989760
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1989770
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-8878220
(
R-HSA-8941856
)
R-HSA-8878220
Reaction Name: RUNX3 binds the NOTCH1 coactivator complex
See in Reactome
R-HSA-1989762
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1980078
(
R-HSA-2122947
)
R-HSA-1980078
Reaction Name: NOTCH1 stimulates HES5 transcription
See in Reactome
R-HSA-4396379
(
R-HSA-2122947
)
R-HSA-4396379
Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter
See in Reactome
R-HSA-9626928
(
R-HSA-9617629
)
R-HSA-1989757
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1368065
(
R-HSA-1989781;
R-HSA-400206;
R-HSA-400253;
R-HSA-9707616
)
R-HSA-1183058
(
R-HSA-381340
)
R-HSA-9622572
(
R-HSA-9614657
)
R-HSA-9622572
Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter
See in Reactome
R-HSA-9761841
()
R-HSA-9761841
Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression
See in Reactome
R-HSA-1989778
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-5617874
(
R-HSA-5617472
)
R-HSA-9760099
()
R-HSA-9760099
Reaction Name: AcK-NFE2L2 binds the GCLC gene
See in Reactome
R-HSA-9760103
()
R-HSA-9760103
Reaction Name: AcK-NFE2L2 binds the GCLM gene
See in Reactome
R-HSA-560472
(
R-HSA-381340
)
R-HSA-560472
Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C)
See in Reactome
R-HSA-1989767
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-8938251
(
R-HSA-8939246
)
R-HSA-8938251
Reaction Name: CSF2 (GM-CSF) gene expression is stimulated by RUNX1 and CREBBP
See in Reactome
R-HSA-1989748
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-4395227
(
R-HSA-1912408
)
R-HSA-4395227
Reaction Name: CCND1:CREBBP binds NOTCH1 promoter
See in Reactome
R-HSA-1989779
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1989759
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1655848
(
R-HSA-1989781;
R-HSA-2426168;
R-HSA-400206
)
R-HSA-1655848
Reaction Name: Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1)
See in Reactome
R-HSA-1235070
(
R-HSA-1234158
)
R-HSA-1235070
Reaction Name: Expression of Erythropoietin (EPO)
See in Reactome
R-HSA-5660660
(
R-HSA-5621575
)
R-HSA-1989752
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1989749
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1989761
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1989768
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-9604499
(
R-HSA-933541
)
R-HSA-9604499
Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300
See in Reactome
R-HSA-9604664
(
R-HSA-9013695
)
R-HSA-9604664
Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4
See in Reactome
R-HSA-5617896
(
R-HSA-5617472
)
R-HSA-5617896
Reaction Name: Retinoic acid activates HOXD4 chromatin
See in Reactome
R-HSA-9759364
()
R-HSA-9759364
Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression
See in Reactome
R-HSA-3322427
(
R-HSA-201722
)
R-HSA-3322427
Reaction Name: Beta-catenin recruits CBP/p300
See in Reactome
R-HSA-1655826
(
R-HSA-1989781;
R-HSA-2426168;
R-HSA-400206
)
R-HSA-1655826
Reaction Name: Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR)
See in Reactome
R-HSA-1989774
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-6797993
(
R-HSA-6803204
)
R-HSA-6797993
Reaction Name: TP53 and CREBBP bind BNIP3L gene
See in Reactome
R-HSA-9759186
()
R-HSA-9759186
Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression
See in Reactome
R-HSA-9760081
()
R-HSA-9760081
Reaction Name: CREBBP, EP300 acetylates NFE2L2
See in Reactome
|
MONDO:0008840 |
ATM |
Q13315 |
2.7.11.1
|
R-HSA-2559586
R-HSA-2559586
Reactome Name: DNA Damage/Telomere Stress Induced Senescence
See in Reactome
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-9664873
R-HSA-69473
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-69541
R-HSA-6803207
R-HSA-6803207
Reactome Name: TP53 Regulates Transcription of Caspase Activators and Caspases
See in Reactome
R-HSA-6803204
R-HSA-6803204
Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5693548
R-HSA-5693548
Reactome Name: Sensing of DNA Double Strand Breaks
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-912446
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-2559583
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-1640170
R-HSA-8953897
R-HSA-73857
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-5633007
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-5633008
R-HSA-5633008
Reactome Name: TP53 Regulates Transcription of Cell Death Genes
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-5693538
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-1474165
R-HSA-9612973
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-9663891
R-HSA-1632852
R-HSA-69481
R-HSA-69615
R-HSA-1500620
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
|
Cell Cycle
Cellular responses to stimuli
Gene expression (Transcription)
Reproduction
Autophagy
DNA Repair
|
R-HSA-3371567
(
R-HSA-3371453
)
R-HSA-3371567
Reaction Name: DBC1 is phosphorylated by ATM/ART
See in Reactome
R-HSA-349444
(
R-HSA-349425;
R-HSA-69541
)
R-HSA-349444
Reaction Name: Phosphorylation of COP1 at Ser-387 by ATM
See in Reactome
R-HSA-349455
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-5682018
(
R-HSA-2559586
)
R-HSA-5682018
Reaction Name: MRN complex bound to shortened telomeres recruits ATM
See in Reactome
R-HSA-5682026
(
R-HSA-2559586
)
R-HSA-5682026
Reaction Name: MRN bound to shortened telomeres activates ATM
See in Reactome
R-HSA-5682044
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5682044
Reaction Name: KAT5 acetylates ATM at DNA DSBs
See in Reactome
R-HSA-5682586
(
R-HSA-5693565
)
R-HSA-5682586
Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs
See in Reactome
R-HSA-5682588
(
R-HSA-5693565
)
R-HSA-5682588
Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs
See in Reactome
R-HSA-5682598
(
R-HSA-5693565
)
R-HSA-5682607
(
R-HSA-5693565
)
R-HSA-5682607
Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
See in Reactome
R-HSA-5682629
(
R-HSA-5693565
)
R-HSA-5682629
Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
See in Reactome
R-HSA-5682858
(
R-HSA-5693565
)
R-HSA-5682858
Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX
See in Reactome
R-HSA-5682863
(
R-HSA-5693565
)
R-HSA-5682965
(
R-HSA-5693565
)
R-HSA-5682965
Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs
See in Reactome
R-HSA-5682967
(
R-HSA-5693565
)
R-HSA-5682983
(
R-HSA-5693565
)
R-HSA-5682992
(
R-HSA-5693565
)
R-HSA-5683077
(
R-HSA-5693565
)
R-HSA-5683077
Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B
See in Reactome
R-HSA-5683384
(
R-HSA-5693565
)
R-HSA-5683384
Reaction Name: UIMC1 and FAM175A bind DNA DSBs
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683405
(
R-HSA-5693565
)
R-HSA-5683405
Reaction Name: PPP5C dephosphorylates TP53BP1
See in Reactome
R-HSA-5683425
(
R-HSA-5693565
)
R-HSA-5683425
Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
R-HSA-5683986
(
R-HSA-5693565
)
R-HSA-5683986
Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX
See in Reactome
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684081
(
R-HSA-5693607
)
R-HSA-5684081
Reaction Name: MRN complex binds CDK2 and RBBP8
See in Reactome
R-HSA-5684096
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684140
(
R-HSA-5693607
)
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686578
(
R-HSA-5693565
)
R-HSA-5686578
Reaction Name: Activated ATM phosphorylates ABL1
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5686704
(
R-HSA-5693571
)
R-HSA-5686704
Reaction Name: Activated ATM phosphorylates DCLRE1C
See in Reactome
R-HSA-5686900
(
R-HSA-5693571
)
R-HSA-5686900
Reaction Name: TP53BP1 recruits DCLRE1C to ATM
See in Reactome
R-HSA-5693536
(
R-HSA-5693565
)
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693540
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693549
(
R-HSA-5693565
)
R-HSA-5693549
Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693566
(
R-HSA-5693565
)
R-HSA-5693566
Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693583
(
R-HSA-5693565
)
R-HSA-5693583
Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693598
(
R-HSA-5693565
)
R-HSA-5693599
(
R-HSA-5693571
)
R-HSA-5693599
Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break
See in Reactome
R-HSA-5693602
(
R-HSA-5693565
)
R-HSA-5693602
Reaction Name: ATM recognizes H2AFX-Nucleosomes
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693609
(
R-HSA-2559586;
R-HSA-5693565;
R-HSA-6804756;
R-HSA-69541
)
R-HSA-5693609
Reaction Name: ATM phosphorylates TP53 at S15
See in Reactome
R-HSA-5693612
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693612
Reaction Name: MRN complex bound to DNA ends recruits ATM
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6792712
(
R-HSA-2559586
)
R-HSA-6792712
Reaction Name: KAT5 acetylates ATM at shortened telomeres
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6798372
(
R-HSA-6804756
)
R-HSA-6799097
(
R-HSA-6803204
)
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-6800490
(
R-HSA-6803207
)
R-HSA-6804276
(
R-HSA-6804760
)
R-HSA-6804741
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-6804741
Reaction Name: MDM2 forms homo- or heterodimers
See in Reactome
R-HSA-6804955
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-912429
(
R-HSA-912446
)
R-HSA-912429
Reaction Name: Resolution of meiotic holliday junction
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912496
(
R-HSA-912446
)
R-HSA-912496
Reaction Name: Formation of meiotic holliday junction
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9664850
(
R-HSA-9664873
)
R-HSA-9664855
(
R-HSA-9664873
)
R-HSA-9664855
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664862
(
R-HSA-9664873
)
R-HSA-9664862
Reaction Name: ATM dimer:PEX5 phosphorylates PEX5
See in Reactome
R-HSA-9664879
(
R-HSA-9664873
)
R-HSA-9664880
(
R-HSA-9664873
)
R-HSA-9664880
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1
See in Reactome
R-HSA-9664881
(
R-HSA-9664873
)
R-HSA-9664881
Reaction Name: NBR1 binds ATM:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664883
(
R-HSA-9664873
)
R-HSA-9664883
Reaction Name: ATM:PEX5 translocates from cytosol to peroxisomal membrane
See in Reactome
R-HSA-9664888
(
R-HSA-9664873
)
R-HSA-9664888
Reaction Name: ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9664892
(
R-HSA-9664873
)
R-HSA-9664892
Reaction Name: SQSTM1 binds ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674127
(
R-HSA-9664873
)
R-HSA-9674127
Reaction Name: USP30 deubiquitinates ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674131
(
R-HSA-9664873
)
R-HSA-9674131
Reaction Name: USP30 binds ATM dimer:Ub-p-PEX5
See in Reactome
|
MONDO:0014094 |
STEAP3 |
Q658P3 |
1.16.1.-
|
R-HSA-917977
R-HSA-917977
Reactome Name: Transferrin endocytosis and recycling
See in Reactome
R-HSA-9035034
R-HSA-6803204
R-HSA-6803204
Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
See in Reactome
R-HSA-9013409
R-HSA-9013406
R-HSA-9013405
R-HSA-9013148
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9012999
R-HSA-212436
R-HSA-74160
R-HSA-5633008
R-HSA-5633008
Reactome Name: TP53 Regulates Transcription of Cell Death Genes
See in Reactome
R-HSA-194315
R-HSA-917937
R-HSA-382551
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Transport of small molecules
Signal Transduction
|
R-HSA-6801184
(
R-HSA-6803204
)
R-HSA-6801184
Reaction Name: TP53 stimulates STEAP3 expression
See in Reactome
R-HSA-6801195
(
R-HSA-6803204
)
R-HSA-9013157
(
R-HSA-9013148
)
R-HSA-9013157
Reaction Name: CDC42 binds effectors at the plasma membrane
See in Reactome
R-HSA-9017507
(
R-HSA-9013409
)
R-HSA-9017507
Reaction Name: RHOJ binds effectors at the plasma membrane
See in Reactome
R-HSA-9018746
(
R-HSA-9013406
)
R-HSA-9018746
Reaction Name: RHOQ binds effectors at the plasma membrane
See in Reactome
R-HSA-917811
(
R-HSA-917977
)
R-HSA-917811
Reaction Name: STEAP3-like proteins reduce Fe3+ to Fe2+
See in Reactome
R-HSA-9693125
(
R-HSA-9035034
)
R-HSA-9693125
Reaction Name: RHOF binds effectors at the plasma membrane
See in Reactome
R-HSA-9693198
(
R-HSA-9013405
)
R-HSA-9693198
Reaction Name: RHOD binds effectors at the plasma membrane
See in Reactome
|
MONDO:0015356 |
ATM |
Q13315 |
2.7.11.1
|
R-HSA-2559586
R-HSA-2559586
Reactome Name: DNA Damage/Telomere Stress Induced Senescence
See in Reactome
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-9664873
R-HSA-69473
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-69541
R-HSA-6803207
R-HSA-6803207
Reactome Name: TP53 Regulates Transcription of Caspase Activators and Caspases
See in Reactome
R-HSA-6803204
R-HSA-6803204
Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5693548
R-HSA-5693548
Reactome Name: Sensing of DNA Double Strand Breaks
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-912446
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-2559583
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-1640170
R-HSA-8953897
R-HSA-73857
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-5633007
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-5633008
R-HSA-5633008
Reactome Name: TP53 Regulates Transcription of Cell Death Genes
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-5693538
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-1474165
R-HSA-9612973
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-9663891
R-HSA-1632852
R-HSA-69481
R-HSA-69615
R-HSA-1500620
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
|
Cell Cycle
Cellular responses to stimuli
Gene expression (Transcription)
Reproduction
Autophagy
DNA Repair
|
R-HSA-3371567
(
R-HSA-3371453
)
R-HSA-3371567
Reaction Name: DBC1 is phosphorylated by ATM/ART
See in Reactome
R-HSA-349444
(
R-HSA-349425;
R-HSA-69541
)
R-HSA-349444
Reaction Name: Phosphorylation of COP1 at Ser-387 by ATM
See in Reactome
R-HSA-349455
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-5682018
(
R-HSA-2559586
)
R-HSA-5682018
Reaction Name: MRN complex bound to shortened telomeres recruits ATM
See in Reactome
R-HSA-5682026
(
R-HSA-2559586
)
R-HSA-5682026
Reaction Name: MRN bound to shortened telomeres activates ATM
See in Reactome
R-HSA-5682044
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5682044
Reaction Name: KAT5 acetylates ATM at DNA DSBs
See in Reactome
R-HSA-5682586
(
R-HSA-5693565
)
R-HSA-5682586
Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs
See in Reactome
R-HSA-5682588
(
R-HSA-5693565
)
R-HSA-5682588
Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs
See in Reactome
R-HSA-5682598
(
R-HSA-5693565
)
R-HSA-5682607
(
R-HSA-5693565
)
R-HSA-5682607
Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
See in Reactome
R-HSA-5682629
(
R-HSA-5693565
)
R-HSA-5682629
Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
See in Reactome
R-HSA-5682858
(
R-HSA-5693565
)
R-HSA-5682858
Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX
See in Reactome
R-HSA-5682863
(
R-HSA-5693565
)
R-HSA-5682965
(
R-HSA-5693565
)
R-HSA-5682965
Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs
See in Reactome
R-HSA-5682967
(
R-HSA-5693565
)
R-HSA-5682983
(
R-HSA-5693565
)
R-HSA-5682992
(
R-HSA-5693565
)
R-HSA-5683077
(
R-HSA-5693565
)
R-HSA-5683077
Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B
See in Reactome
R-HSA-5683384
(
R-HSA-5693565
)
R-HSA-5683384
Reaction Name: UIMC1 and FAM175A bind DNA DSBs
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683405
(
R-HSA-5693565
)
R-HSA-5683405
Reaction Name: PPP5C dephosphorylates TP53BP1
See in Reactome
R-HSA-5683425
(
R-HSA-5693565
)
R-HSA-5683425
Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
R-HSA-5683986
(
R-HSA-5693565
)
R-HSA-5683986
Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX
See in Reactome
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684081
(
R-HSA-5693607
)
R-HSA-5684081
Reaction Name: MRN complex binds CDK2 and RBBP8
See in Reactome
R-HSA-5684096
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684140
(
R-HSA-5693607
)
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686578
(
R-HSA-5693565
)
R-HSA-5686578
Reaction Name: Activated ATM phosphorylates ABL1
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5686704
(
R-HSA-5693571
)
R-HSA-5686704
Reaction Name: Activated ATM phosphorylates DCLRE1C
See in Reactome
R-HSA-5686900
(
R-HSA-5693571
)
R-HSA-5686900
Reaction Name: TP53BP1 recruits DCLRE1C to ATM
See in Reactome
R-HSA-5693536
(
R-HSA-5693565
)
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693540
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693549
(
R-HSA-5693565
)
R-HSA-5693549
Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693566
(
R-HSA-5693565
)
R-HSA-5693566
Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693583
(
R-HSA-5693565
)
R-HSA-5693583
Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693598
(
R-HSA-5693565
)
R-HSA-5693599
(
R-HSA-5693571
)
R-HSA-5693599
Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break
See in Reactome
R-HSA-5693602
(
R-HSA-5693565
)
R-HSA-5693602
Reaction Name: ATM recognizes H2AFX-Nucleosomes
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693609
(
R-HSA-2559586;
R-HSA-5693565;
R-HSA-6804756;
R-HSA-69541
)
R-HSA-5693609
Reaction Name: ATM phosphorylates TP53 at S15
See in Reactome
R-HSA-5693612
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693612
Reaction Name: MRN complex bound to DNA ends recruits ATM
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6792712
(
R-HSA-2559586
)
R-HSA-6792712
Reaction Name: KAT5 acetylates ATM at shortened telomeres
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6798372
(
R-HSA-6804756
)
R-HSA-6799097
(
R-HSA-6803204
)
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-6800490
(
R-HSA-6803207
)
R-HSA-6804276
(
R-HSA-6804760
)
R-HSA-6804741
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-6804741
Reaction Name: MDM2 forms homo- or heterodimers
See in Reactome
R-HSA-6804955
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-912429
(
R-HSA-912446
)
R-HSA-912429
Reaction Name: Resolution of meiotic holliday junction
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912496
(
R-HSA-912446
)
R-HSA-912496
Reaction Name: Formation of meiotic holliday junction
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9664850
(
R-HSA-9664873
)
R-HSA-9664855
(
R-HSA-9664873
)
R-HSA-9664855
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664862
(
R-HSA-9664873
)
R-HSA-9664862
Reaction Name: ATM dimer:PEX5 phosphorylates PEX5
See in Reactome
R-HSA-9664879
(
R-HSA-9664873
)
R-HSA-9664880
(
R-HSA-9664873
)
R-HSA-9664880
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1
See in Reactome
R-HSA-9664881
(
R-HSA-9664873
)
R-HSA-9664881
Reaction Name: NBR1 binds ATM:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664883
(
R-HSA-9664873
)
R-HSA-9664883
Reaction Name: ATM:PEX5 translocates from cytosol to peroxisomal membrane
See in Reactome
R-HSA-9664888
(
R-HSA-9664873
)
R-HSA-9664888
Reaction Name: ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9664892
(
R-HSA-9664873
)
R-HSA-9664892
Reaction Name: SQSTM1 binds ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674127
(
R-HSA-9664873
)
R-HSA-9674127
Reaction Name: USP30 deubiquitinates ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674131
(
R-HSA-9664873
)
R-HSA-9674131
Reaction Name: USP30 binds ATM dimer:Ub-p-PEX5
See in Reactome
|
MONDO:0016419 |
ATM |
Q13315 |
2.7.11.1
|
R-HSA-2559586
R-HSA-2559586
Reactome Name: DNA Damage/Telomere Stress Induced Senescence
See in Reactome
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-9664873
R-HSA-69473
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-69541
R-HSA-6803207
R-HSA-6803207
Reactome Name: TP53 Regulates Transcription of Caspase Activators and Caspases
See in Reactome
R-HSA-6803204
R-HSA-6803204
Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5693548
R-HSA-5693548
Reactome Name: Sensing of DNA Double Strand Breaks
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-912446
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-2559583
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-1640170
R-HSA-8953897
R-HSA-73857
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-5633007
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-5633008
R-HSA-5633008
Reactome Name: TP53 Regulates Transcription of Cell Death Genes
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-5693538
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-1474165
R-HSA-9612973
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-9663891
R-HSA-1632852
R-HSA-69481
R-HSA-69615
R-HSA-1500620
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
|
Cell Cycle
Cellular responses to stimuli
Gene expression (Transcription)
Reproduction
Autophagy
DNA Repair
|
R-HSA-3371567
(
R-HSA-3371453
)
R-HSA-3371567
Reaction Name: DBC1 is phosphorylated by ATM/ART
See in Reactome
R-HSA-349444
(
R-HSA-349425;
R-HSA-69541
)
R-HSA-349444
Reaction Name: Phosphorylation of COP1 at Ser-387 by ATM
See in Reactome
R-HSA-349455
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-5682018
(
R-HSA-2559586
)
R-HSA-5682018
Reaction Name: MRN complex bound to shortened telomeres recruits ATM
See in Reactome
R-HSA-5682026
(
R-HSA-2559586
)
R-HSA-5682026
Reaction Name: MRN bound to shortened telomeres activates ATM
See in Reactome
R-HSA-5682044
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5682044
Reaction Name: KAT5 acetylates ATM at DNA DSBs
See in Reactome
R-HSA-5682586
(
R-HSA-5693565
)
R-HSA-5682586
Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs
See in Reactome
R-HSA-5682588
(
R-HSA-5693565
)
R-HSA-5682588
Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs
See in Reactome
R-HSA-5682598
(
R-HSA-5693565
)
R-HSA-5682607
(
R-HSA-5693565
)
R-HSA-5682607
Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
See in Reactome
R-HSA-5682629
(
R-HSA-5693565
)
R-HSA-5682629
Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
See in Reactome
R-HSA-5682858
(
R-HSA-5693565
)
R-HSA-5682858
Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX
See in Reactome
R-HSA-5682863
(
R-HSA-5693565
)
R-HSA-5682965
(
R-HSA-5693565
)
R-HSA-5682965
Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs
See in Reactome
R-HSA-5682967
(
R-HSA-5693565
)
R-HSA-5682983
(
R-HSA-5693565
)
R-HSA-5682992
(
R-HSA-5693565
)
R-HSA-5683077
(
R-HSA-5693565
)
R-HSA-5683077
Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B
See in Reactome
R-HSA-5683384
(
R-HSA-5693565
)
R-HSA-5683384
Reaction Name: UIMC1 and FAM175A bind DNA DSBs
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683405
(
R-HSA-5693565
)
R-HSA-5683405
Reaction Name: PPP5C dephosphorylates TP53BP1
See in Reactome
R-HSA-5683425
(
R-HSA-5693565
)
R-HSA-5683425
Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
R-HSA-5683986
(
R-HSA-5693565
)
R-HSA-5683986
Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX
See in Reactome
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684081
(
R-HSA-5693607
)
R-HSA-5684081
Reaction Name: MRN complex binds CDK2 and RBBP8
See in Reactome
R-HSA-5684096
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684140
(
R-HSA-5693607
)
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686578
(
R-HSA-5693565
)
R-HSA-5686578
Reaction Name: Activated ATM phosphorylates ABL1
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5686704
(
R-HSA-5693571
)
R-HSA-5686704
Reaction Name: Activated ATM phosphorylates DCLRE1C
See in Reactome
R-HSA-5686900
(
R-HSA-5693571
)
R-HSA-5686900
Reaction Name: TP53BP1 recruits DCLRE1C to ATM
See in Reactome
R-HSA-5693536
(
R-HSA-5693565
)
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693540
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693549
(
R-HSA-5693565
)
R-HSA-5693549
Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693566
(
R-HSA-5693565
)
R-HSA-5693566
Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693583
(
R-HSA-5693565
)
R-HSA-5693583
Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693598
(
R-HSA-5693565
)
R-HSA-5693599
(
R-HSA-5693571
)
R-HSA-5693599
Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break
See in Reactome
R-HSA-5693602
(
R-HSA-5693565
)
R-HSA-5693602
Reaction Name: ATM recognizes H2AFX-Nucleosomes
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693609
(
R-HSA-2559586;
R-HSA-5693565;
R-HSA-6804756;
R-HSA-69541
)
R-HSA-5693609
Reaction Name: ATM phosphorylates TP53 at S15
See in Reactome
R-HSA-5693612
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693612
Reaction Name: MRN complex bound to DNA ends recruits ATM
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6792712
(
R-HSA-2559586
)
R-HSA-6792712
Reaction Name: KAT5 acetylates ATM at shortened telomeres
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6798372
(
R-HSA-6804756
)
R-HSA-6799097
(
R-HSA-6803204
)
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-6800490
(
R-HSA-6803207
)
R-HSA-6804276
(
R-HSA-6804760
)
R-HSA-6804741
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-6804741
Reaction Name: MDM2 forms homo- or heterodimers
See in Reactome
R-HSA-6804955
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-912429
(
R-HSA-912446
)
R-HSA-912429
Reaction Name: Resolution of meiotic holliday junction
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912496
(
R-HSA-912446
)
R-HSA-912496
Reaction Name: Formation of meiotic holliday junction
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9664850
(
R-HSA-9664873
)
R-HSA-9664855
(
R-HSA-9664873
)
R-HSA-9664855
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664862
(
R-HSA-9664873
)
R-HSA-9664862
Reaction Name: ATM dimer:PEX5 phosphorylates PEX5
See in Reactome
R-HSA-9664879
(
R-HSA-9664873
)
R-HSA-9664880
(
R-HSA-9664873
)
R-HSA-9664880
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1
See in Reactome
R-HSA-9664881
(
R-HSA-9664873
)
R-HSA-9664881
Reaction Name: NBR1 binds ATM:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664883
(
R-HSA-9664873
)
R-HSA-9664883
Reaction Name: ATM:PEX5 translocates from cytosol to peroxisomal membrane
See in Reactome
R-HSA-9664888
(
R-HSA-9664873
)
R-HSA-9664888
Reaction Name: ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9664892
(
R-HSA-9664873
)
R-HSA-9664892
Reaction Name: SQSTM1 binds ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674127
(
R-HSA-9664873
)
R-HSA-9674127
Reaction Name: USP30 deubiquitinates ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674131
(
R-HSA-9664873
)
R-HSA-9674131
Reaction Name: USP30 binds ATM dimer:Ub-p-PEX5
See in Reactome
|
MONDO:0018266 |
ATM |
Q13315 |
2.7.11.1
|
R-HSA-2559586
R-HSA-2559586
Reactome Name: DNA Damage/Telomere Stress Induced Senescence
See in Reactome
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-9664873
R-HSA-69473
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-69541
R-HSA-6803207
R-HSA-6803207
Reactome Name: TP53 Regulates Transcription of Caspase Activators and Caspases
See in Reactome
R-HSA-6803204
R-HSA-6803204
Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5693548
R-HSA-5693548
Reactome Name: Sensing of DNA Double Strand Breaks
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-912446
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-2559583
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-1640170
R-HSA-8953897
R-HSA-73857
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-5633007
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-5633008
R-HSA-5633008
Reactome Name: TP53 Regulates Transcription of Cell Death Genes
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-5693538
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-1474165
R-HSA-9612973
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-9663891
R-HSA-1632852
R-HSA-69481
R-HSA-69615
R-HSA-1500620
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
|
Cell Cycle
Cellular responses to stimuli
Gene expression (Transcription)
Reproduction
Autophagy
DNA Repair
|
R-HSA-3371567
(
R-HSA-3371453
)
R-HSA-3371567
Reaction Name: DBC1 is phosphorylated by ATM/ART
See in Reactome
R-HSA-349444
(
R-HSA-349425;
R-HSA-69541
)
R-HSA-349444
Reaction Name: Phosphorylation of COP1 at Ser-387 by ATM
See in Reactome
R-HSA-349455
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-5682018
(
R-HSA-2559586
)
R-HSA-5682018
Reaction Name: MRN complex bound to shortened telomeres recruits ATM
See in Reactome
R-HSA-5682026
(
R-HSA-2559586
)
R-HSA-5682026
Reaction Name: MRN bound to shortened telomeres activates ATM
See in Reactome
R-HSA-5682044
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5682044
Reaction Name: KAT5 acetylates ATM at DNA DSBs
See in Reactome
R-HSA-5682586
(
R-HSA-5693565
)
R-HSA-5682586
Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs
See in Reactome
R-HSA-5682588
(
R-HSA-5693565
)
R-HSA-5682588
Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs
See in Reactome
R-HSA-5682598
(
R-HSA-5693565
)
R-HSA-5682607
(
R-HSA-5693565
)
R-HSA-5682607
Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
See in Reactome
R-HSA-5682629
(
R-HSA-5693565
)
R-HSA-5682629
Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
See in Reactome
R-HSA-5682858
(
R-HSA-5693565
)
R-HSA-5682858
Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX
See in Reactome
R-HSA-5682863
(
R-HSA-5693565
)
R-HSA-5682965
(
R-HSA-5693565
)
R-HSA-5682965
Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs
See in Reactome
R-HSA-5682967
(
R-HSA-5693565
)
R-HSA-5682983
(
R-HSA-5693565
)
R-HSA-5682992
(
R-HSA-5693565
)
R-HSA-5683077
(
R-HSA-5693565
)
R-HSA-5683077
Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B
See in Reactome
R-HSA-5683384
(
R-HSA-5693565
)
R-HSA-5683384
Reaction Name: UIMC1 and FAM175A bind DNA DSBs
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683405
(
R-HSA-5693565
)
R-HSA-5683405
Reaction Name: PPP5C dephosphorylates TP53BP1
See in Reactome
R-HSA-5683425
(
R-HSA-5693565
)
R-HSA-5683425
Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
R-HSA-5683986
(
R-HSA-5693565
)
R-HSA-5683986
Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX
See in Reactome
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684081
(
R-HSA-5693607
)
R-HSA-5684081
Reaction Name: MRN complex binds CDK2 and RBBP8
See in Reactome
R-HSA-5684096
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684140
(
R-HSA-5693607
)
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686578
(
R-HSA-5693565
)
R-HSA-5686578
Reaction Name: Activated ATM phosphorylates ABL1
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5686704
(
R-HSA-5693571
)
R-HSA-5686704
Reaction Name: Activated ATM phosphorylates DCLRE1C
See in Reactome
R-HSA-5686900
(
R-HSA-5693571
)
R-HSA-5686900
Reaction Name: TP53BP1 recruits DCLRE1C to ATM
See in Reactome
R-HSA-5693536
(
R-HSA-5693565
)
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693540
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693549
(
R-HSA-5693565
)
R-HSA-5693549
Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693566
(
R-HSA-5693565
)
R-HSA-5693566
Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693583
(
R-HSA-5693565
)
R-HSA-5693583
Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693598
(
R-HSA-5693565
)
R-HSA-5693599
(
R-HSA-5693571
)
R-HSA-5693599
Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break
See in Reactome
R-HSA-5693602
(
R-HSA-5693565
)
R-HSA-5693602
Reaction Name: ATM recognizes H2AFX-Nucleosomes
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693609
(
R-HSA-2559586;
R-HSA-5693565;
R-HSA-6804756;
R-HSA-69541
)
R-HSA-5693609
Reaction Name: ATM phosphorylates TP53 at S15
See in Reactome
R-HSA-5693612
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693612
Reaction Name: MRN complex bound to DNA ends recruits ATM
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6792712
(
R-HSA-2559586
)
R-HSA-6792712
Reaction Name: KAT5 acetylates ATM at shortened telomeres
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6798372
(
R-HSA-6804756
)
R-HSA-6799097
(
R-HSA-6803204
)
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-6800490
(
R-HSA-6803207
)
R-HSA-6804276
(
R-HSA-6804760
)
R-HSA-6804741
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-6804741
Reaction Name: MDM2 forms homo- or heterodimers
See in Reactome
R-HSA-6804955
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-912429
(
R-HSA-912446
)
R-HSA-912429
Reaction Name: Resolution of meiotic holliday junction
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912496
(
R-HSA-912446
)
R-HSA-912496
Reaction Name: Formation of meiotic holliday junction
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9664850
(
R-HSA-9664873
)
R-HSA-9664855
(
R-HSA-9664873
)
R-HSA-9664855
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664862
(
R-HSA-9664873
)
R-HSA-9664862
Reaction Name: ATM dimer:PEX5 phosphorylates PEX5
See in Reactome
R-HSA-9664879
(
R-HSA-9664873
)
R-HSA-9664880
(
R-HSA-9664873
)
R-HSA-9664880
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1
See in Reactome
R-HSA-9664881
(
R-HSA-9664873
)
R-HSA-9664881
Reaction Name: NBR1 binds ATM:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664883
(
R-HSA-9664873
)
R-HSA-9664883
Reaction Name: ATM:PEX5 translocates from cytosol to peroxisomal membrane
See in Reactome
R-HSA-9664888
(
R-HSA-9664873
)
R-HSA-9664888
Reaction Name: ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9664892
(
R-HSA-9664873
)
R-HSA-9664892
Reaction Name: SQSTM1 binds ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674127
(
R-HSA-9664873
)
R-HSA-9674127
Reaction Name: USP30 deubiquitinates ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674131
(
R-HSA-9664873
)
R-HSA-9674131
Reaction Name: USP30 binds ATM dimer:Ub-p-PEX5
See in Reactome
|
MONDO:0018876 |
MONDO:0018876
Disease Name: mantle cell lymphoma
Orphanet id: Orphanet:52416
All associated enzymes in DAR:
ATM
. The disease is also associated to other non-enzyme proteins (not in DAR).
ATM |
Q13315 |
2.7.11.1
|
R-HSA-2559586
R-HSA-2559586
Reactome Name: DNA Damage/Telomere Stress Induced Senescence
See in Reactome
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-9664873
R-HSA-69473
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-69541
R-HSA-6803207
R-HSA-6803207
Reactome Name: TP53 Regulates Transcription of Caspase Activators and Caspases
See in Reactome
R-HSA-6803204
R-HSA-6803204
Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5693548
R-HSA-5693548
Reactome Name: Sensing of DNA Double Strand Breaks
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-912446
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-2559583
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-1640170
R-HSA-8953897
R-HSA-73857
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-5633007
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-5633008
R-HSA-5633008
Reactome Name: TP53 Regulates Transcription of Cell Death Genes
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-5693538
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-1474165
R-HSA-9612973
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-9663891
R-HSA-1632852
R-HSA-69481
R-HSA-69615
R-HSA-1500620
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
|
Cell Cycle
Cellular responses to stimuli
Gene expression (Transcription)
Reproduction
Autophagy
DNA Repair
|
R-HSA-3371567
(
R-HSA-3371453
)
R-HSA-3371567
Reaction Name: DBC1 is phosphorylated by ATM/ART
See in Reactome
R-HSA-349444
(
R-HSA-349425;
R-HSA-69541
)
R-HSA-349444
Reaction Name: Phosphorylation of COP1 at Ser-387 by ATM
See in Reactome
R-HSA-349455
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-5682018
(
R-HSA-2559586
)
R-HSA-5682018
Reaction Name: MRN complex bound to shortened telomeres recruits ATM
See in Reactome
R-HSA-5682026
(
R-HSA-2559586
)
R-HSA-5682026
Reaction Name: MRN bound to shortened telomeres activates ATM
See in Reactome
R-HSA-5682044
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5682044
Reaction Name: KAT5 acetylates ATM at DNA DSBs
See in Reactome
R-HSA-5682586
(
R-HSA-5693565
)
R-HSA-5682586
Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs
See in Reactome
R-HSA-5682588
(
R-HSA-5693565
)
R-HSA-5682588
Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs
See in Reactome
R-HSA-5682598
(
R-HSA-5693565
)
R-HSA-5682607
(
R-HSA-5693565
)
R-HSA-5682607
Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
See in Reactome
R-HSA-5682629
(
R-HSA-5693565
)
R-HSA-5682629
Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
See in Reactome
R-HSA-5682858
(
R-HSA-5693565
)
R-HSA-5682858
Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX
See in Reactome
R-HSA-5682863
(
R-HSA-5693565
)
R-HSA-5682965
(
R-HSA-5693565
)
R-HSA-5682965
Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs
See in Reactome
R-HSA-5682967
(
R-HSA-5693565
)
R-HSA-5682983
(
R-HSA-5693565
)
R-HSA-5682992
(
R-HSA-5693565
)
R-HSA-5683077
(
R-HSA-5693565
)
R-HSA-5683077
Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B
See in Reactome
R-HSA-5683384
(
R-HSA-5693565
)
R-HSA-5683384
Reaction Name: UIMC1 and FAM175A bind DNA DSBs
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683405
(
R-HSA-5693565
)
R-HSA-5683405
Reaction Name: PPP5C dephosphorylates TP53BP1
See in Reactome
R-HSA-5683425
(
R-HSA-5693565
)
R-HSA-5683425
Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
R-HSA-5683986
(
R-HSA-5693565
)
R-HSA-5683986
Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX
See in Reactome
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684081
(
R-HSA-5693607
)
R-HSA-5684081
Reaction Name: MRN complex binds CDK2 and RBBP8
See in Reactome
R-HSA-5684096
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684140
(
R-HSA-5693607
)
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686578
(
R-HSA-5693565
)
R-HSA-5686578
Reaction Name: Activated ATM phosphorylates ABL1
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5686704
(
R-HSA-5693571
)
R-HSA-5686704
Reaction Name: Activated ATM phosphorylates DCLRE1C
See in Reactome
R-HSA-5686900
(
R-HSA-5693571
)
R-HSA-5686900
Reaction Name: TP53BP1 recruits DCLRE1C to ATM
See in Reactome
R-HSA-5693536
(
R-HSA-5693565
)
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693540
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693549
(
R-HSA-5693565
)
R-HSA-5693549
Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693566
(
R-HSA-5693565
)
R-HSA-5693566
Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693583
(
R-HSA-5693565
)
R-HSA-5693583
Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693598
(
R-HSA-5693565
)
R-HSA-5693599
(
R-HSA-5693571
)
R-HSA-5693599
Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break
See in Reactome
R-HSA-5693602
(
R-HSA-5693565
)
R-HSA-5693602
Reaction Name: ATM recognizes H2AFX-Nucleosomes
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693609
(
R-HSA-2559586;
R-HSA-5693565;
R-HSA-6804756;
R-HSA-69541
)
R-HSA-5693609
Reaction Name: ATM phosphorylates TP53 at S15
See in Reactome
R-HSA-5693612
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693612
Reaction Name: MRN complex bound to DNA ends recruits ATM
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6792712
(
R-HSA-2559586
)
R-HSA-6792712
Reaction Name: KAT5 acetylates ATM at shortened telomeres
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6798372
(
R-HSA-6804756
)
R-HSA-6799097
(
R-HSA-6803204
)
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-6800490
(
R-HSA-6803207
)
R-HSA-6804276
(
R-HSA-6804760
)
R-HSA-6804741
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-6804741
Reaction Name: MDM2 forms homo- or heterodimers
See in Reactome
R-HSA-6804955
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-912429
(
R-HSA-912446
)
R-HSA-912429
Reaction Name: Resolution of meiotic holliday junction
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912496
(
R-HSA-912446
)
R-HSA-912496
Reaction Name: Formation of meiotic holliday junction
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9664850
(
R-HSA-9664873
)
R-HSA-9664855
(
R-HSA-9664873
)
R-HSA-9664855
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664862
(
R-HSA-9664873
)
R-HSA-9664862
Reaction Name: ATM dimer:PEX5 phosphorylates PEX5
See in Reactome
R-HSA-9664879
(
R-HSA-9664873
)
R-HSA-9664880
(
R-HSA-9664873
)
R-HSA-9664880
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1
See in Reactome
R-HSA-9664881
(
R-HSA-9664873
)
R-HSA-9664881
Reaction Name: NBR1 binds ATM:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664883
(
R-HSA-9664873
)
R-HSA-9664883
Reaction Name: ATM:PEX5 translocates from cytosol to peroxisomal membrane
See in Reactome
R-HSA-9664888
(
R-HSA-9664873
)
R-HSA-9664888
Reaction Name: ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9664892
(
R-HSA-9664873
)
R-HSA-9664892
Reaction Name: SQSTM1 binds ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674127
(
R-HSA-9664873
)
R-HSA-9674127
Reaction Name: USP30 deubiquitinates ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674131
(
R-HSA-9664873
)
R-HSA-9674131
Reaction Name: USP30 binds ATM dimer:Ub-p-PEX5
See in Reactome
|
MONDO:0020763 |
CREBBP |
Q92793 |
2.3.1.-
2.3.1.48
|
R-HSA-9617629
R-HSA-9617629
Reactome Name: Regulation of FOXO transcriptional activity by acetylation
See in Reactome
R-HSA-210744
R-HSA-210744
Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
See in Reactome
R-HSA-381340
R-HSA-381340
Reactome Name: Transcriptional regulation of white adipocyte differentiation
See in Reactome
R-HSA-8939246
R-HSA-8939246
Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
See in Reactome
R-HSA-9013695
R-HSA-9013695
Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription
See in Reactome
R-HSA-2151201
R-HSA-2151201
Reactome Name: Transcriptional activation of mitochondrial biogenesis
See in Reactome
R-HSA-8941856
R-HSA-8941856
Reactome Name: RUNX3 regulates NOTCH signaling
See in Reactome
R-HSA-350054
R-HSA-350054
Reactome Name: Notch-HLH transcription pathway
See in Reactome
R-HSA-1989781
R-HSA-1989781
Reactome Name: PPARA activates gene expression
See in Reactome
R-HSA-9018519
R-HSA-9018519
Reactome Name: Estrogen-dependent gene expression
See in Reactome
R-HSA-918233
R-HSA-918233
Reactome Name: TRAF3-dependent IRF activation pathway
See in Reactome
R-HSA-400206
R-HSA-400206
Reactome Name: Regulation of lipid metabolism by PPARalpha
See in Reactome
R-HSA-2426168
R-HSA-2426168
Reactome Name: Activation of gene expression by SREBF (SREBP)
See in Reactome
R-HSA-9013508
R-HSA-9013508
Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription
See in Reactome
R-HSA-3214847
R-HSA-3371568
R-HSA-8866907
R-HSA-8866907
Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors
See in Reactome
R-HSA-6803204
R-HSA-6803204
Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
See in Reactome
R-HSA-9614657
R-HSA-9614657
Reactome Name: FOXO-mediated transcription of cell death genes
See in Reactome
R-HSA-933541
R-HSA-1234158
R-HSA-1234158
Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor
See in Reactome
R-HSA-1368082
R-HSA-1368082
Reactome Name: RORA activates gene expression
See in Reactome
R-HSA-5617472
R-HSA-5617472
Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis
See in Reactome
R-HSA-3899300
R-HSA-3899300
Reactome Name: SUMOylation of transcription cofactors
See in Reactome
R-HSA-2122947
R-HSA-2122947
Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription
See in Reactome
R-HSA-1368108
R-HSA-1368108
Reactome Name: BMAL1:CLOCK,NPAS2 activates circadian gene expression
See in Reactome
R-HSA-400253
R-HSA-9707616
R-HSA-3134973
R-HSA-3134973
Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
See in Reactome
R-HSA-201722
R-HSA-201722
Reactome Name: Formation of the beta-catenin:TCF transactivating complex
See in Reactome
R-HSA-1912408
R-HSA-1912408
Reactome Name: Pre-NOTCH Transcription and Translation
See in Reactome
R-HSA-5621575
R-HSA-9707564
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9012852
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-168256
R-HSA-157118
R-HSA-1592230
R-HSA-1430728
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5633008
R-HSA-5633008
Reactome Name: TP53 Regulates Transcription of Cell Death Genes
See in Reactome
R-HSA-8864260
R-HSA-8864260
Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-1852241
R-HSA-1852241
Reactome Name: Organelle biogenesis and maintenance
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-2990846
R-HSA-556833
R-HSA-8957322
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-8953897
R-HSA-5619507
R-HSA-5619507
Reactome Name: Activation of HOX genes during differentiation
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-1234174
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-195721
R-HSA-8939211
R-HSA-9711123
R-HSA-9711123
Reactome Name: Cellular response to chemical stress
See in Reactome
R-HSA-1912422
R-HSA-1912422
Reactome Name: Pre-NOTCH Expression and Processing
See in Reactome
R-HSA-9013694
R-HSA-3247509
R-HSA-1980143
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-9614085
R-HSA-1655829
R-HSA-1655829
Reactome Name: Regulation of cholesterol biosynthesis by SREBP (SREBF)
See in Reactome
R-HSA-3108232
R-HSA-3108232
Reactome Name: SUMO E3 ligases SUMOylate target proteins
See in Reactome
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-4839726
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-2262752
R-HSA-162582
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
|
Circadian Clock
Immune System
Metabolism
Developmental Biology
Gene expression (Transcription)
Organelle biogenesis and maintenance
Cellular responses to stimuli
Metabolism of proteins
Chromatin organization
Signal Transduction
|
R-HSA-1989746
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-9761836
()
R-HSA-9761836
Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300
See in Reactome
R-HSA-560491
(
R-HSA-381340
)
R-HSA-1989756
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1989754
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-4396371
(
R-HSA-2122947
)
R-HSA-4396371
Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter
See in Reactome
R-HSA-9038052
(
R-HSA-9018519
)
R-HSA-9038052
Reaction Name: GREB1 binds ESR1:ESTG and co-activators
See in Reactome
R-HSA-1234167
(
R-HSA-1234158
)
R-HSA-1234167
Reaction Name: Formation of HIF:CBP:p300 complex at promoters
See in Reactome
R-HSA-9617758
(
R-HSA-9617629
)
R-HSA-9016751
(
R-HSA-9013508
)
R-HSA-9016751
Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3
See in Reactome
R-HSA-560498
(
R-HSA-381340
)
R-HSA-560498
Reaction Name: Expression of Lipoprotein lipase (LPL)
See in Reactome
R-HSA-1980065
(
R-HSA-2122947
)
R-HSA-1980065
Reaction Name: NOTCH1 stimulates HEY transcription
See in Reactome
R-HSA-9759332
()
R-HSA-9759332
Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter
See in Reactome
R-HSA-1989755
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1980067
(
R-HSA-2122947
)
R-HSA-1980067
Reaction Name: NOTCH1 stimulates MYC transcription
See in Reactome
R-HSA-9761849
()
R-HSA-9761849
Reaction Name: AcK-NFE2L2-dependent P6GD gene expression
See in Reactome
R-HSA-1183003
(
R-HSA-381340
)
R-HSA-3134883
(
R-HSA-3134973
)
R-HSA-3134883
Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300
See in Reactome
R-HSA-381309
(
R-HSA-381340
)
R-HSA-381309
Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands
See in Reactome
R-HSA-1028820
(
R-HSA-933541
)
R-HSA-1028820
Reaction Name: Formation of VAF (virus-activated factor) complex
See in Reactome
R-HSA-8878243
(
R-HSA-8941856
)
R-HSA-8878243
Reaction Name: HES1 gene transcription is inhibited by RUNX3
See in Reactome
R-HSA-1989753
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-9021450
(
R-HSA-9013508
)
R-HSA-9021450
Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes
See in Reactome
R-HSA-9761828
()
R-HSA-8938231
(
R-HSA-8939246
)
R-HSA-1028817
(
R-HSA-918233
)
R-HSA-1028817
Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3
See in Reactome
R-HSA-400143
(
R-HSA-400206;
R-HSA-9707564
)
R-HSA-400143
Reaction Name: Fatty acid ligands activate PPARA
See in Reactome
R-HSA-9761846
()
R-HSA-9761846
Reaction Name: NFE2L2-dependent PGD gene expression
See in Reactome
R-HSA-4396347
(
R-HSA-2122947;
R-HSA-8941856
)
R-HSA-4396347
Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter
See in Reactome
R-HSA-9759141
()
R-HSA-9759141
Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene
See in Reactome
R-HSA-9760125
()
R-HSA-9760125
Reaction Name: AcK-NFE2L2-dependent GCLM gene expression
See in Reactome
R-HSA-1592238
(
R-HSA-1989781;
R-HSA-2151201;
R-HSA-400206
)
R-HSA-1989751
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1989777
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-560473
(
R-HSA-1989781;
R-HSA-381340;
R-HSA-400206
)
R-HSA-9622604
(
R-HSA-9614657
)
R-HSA-9622604
Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y
See in Reactome
R-HSA-3371554
(
R-HSA-3371568
)
R-HSA-1989745
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-9017835
(
R-HSA-1912408
)
R-HSA-9017835
Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene
See in Reactome
R-HSA-1989772
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1989771
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1655850
(
R-HSA-1989781;
R-HSA-2426168;
R-HSA-400206
)
R-HSA-1655850
Reaction Name: Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase)
See in Reactome
R-HSA-3927959
(
R-HSA-3899300
)
R-HSA-3927959
Reaction Name: SUMOylation of CREBBP with SUMO1
See in Reactome
R-HSA-1801587
(
R-HSA-1368082;
R-HSA-1989781;
R-HSA-400206;
R-HSA-400253
)
R-HSA-9761812
()
R-HSA-9761812
Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD
See in Reactome
R-HSA-4396382
(
R-HSA-2122947
)
R-HSA-4396382
Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes
See in Reactome
R-HSA-560510
(
R-HSA-381340
)
R-HSA-9760097
()
R-HSA-9760097
Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene
See in Reactome
R-HSA-212356
(
R-HSA-350054
)
R-HSA-212356
Reaction Name: Formation of CSL-NICD coactivator complex
See in Reactome
R-HSA-879724
(
R-HSA-1368108;
R-HSA-1989781;
R-HSA-400206;
R-HSA-400253
)
R-HSA-1980047
(
R-HSA-210744;
R-HSA-2122947;
R-HSA-8941856
)
R-HSA-1980047
Reaction Name: NOTCH1 stimulates HES1 transcription
See in Reactome
R-HSA-9626945
(
R-HSA-9617629
)
R-HSA-1235037
(
R-HSA-1234158
)
R-HSA-8878237
(
R-HSA-8941856
)
R-HSA-8878237
Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter
See in Reactome
R-HSA-9622579
(
R-HSA-9614657
)
R-HSA-9622579
Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter
See in Reactome
R-HSA-933536
(
R-HSA-933541
)
R-HSA-933536
Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300
See in Reactome
R-HSA-6798004
(
R-HSA-6803204
)
R-HSA-6798004
Reaction Name: TP53 stimulates BNIP3L expression
See in Reactome
R-HSA-9760128
()
R-HSA-9760128
Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression
See in Reactome
R-HSA-9617683
(
R-HSA-9617629
)
R-HSA-9617683
Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4
See in Reactome
R-HSA-1912415
(
R-HSA-1912408
)
R-HSA-1028812
(
R-HSA-918233
)
R-HSA-1989773
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-9760082
()
R-HSA-1912394
(
R-HSA-2122947
)
R-HSA-1912394
Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML
See in Reactome
R-HSA-560493
(
R-HSA-381340
)
R-HSA-8938228
(
R-HSA-8939246
)
R-HSA-8938228
Reaction Name: RUNX1:CBFB:CREBBP binds the CSF2 (GM-CSF) gene promoter
See in Reactome
R-HSA-1989765
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-560517
(
R-HSA-1989781;
R-HSA-381340;
R-HSA-400206
)
R-HSA-560517
Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT)
See in Reactome
R-HSA-1912393
(
R-HSA-2122947
)
R-HSA-1912393
Reaction Name: MAML in complex with NICD1 recruits CDK8
See in Reactome
R-HSA-1989764
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1989758
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1028819
(
R-HSA-933541
)
R-HSA-1028819
Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes
See in Reactome
R-HSA-5660666
(
R-HSA-5621575
)
R-HSA-5660666
Reaction Name: CBP and p300 binds NF-kB complex
See in Reactome
R-HSA-1912416
(
R-HSA-1912408
)
R-HSA-1989750
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1912391
(
R-HSA-2122947
)
R-HSA-1912391
Reaction Name: NICD1 is phosphorylated by CDK8
See in Reactome
R-HSA-9761815
()
R-HSA-9761815
Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene
See in Reactome
R-HSA-9760122
()
R-HSA-9760122
Reaction Name: AcK-NFE2L2-dependent GCLC gene expression
See in Reactome
R-HSA-1989775
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1235035
(
R-HSA-1234158
)
R-HSA-1235035
Reaction Name: Expression of Carbonic Anhydrase IX (CA9)
See in Reactome
R-HSA-9021451
(
R-HSA-9013508
)
R-HSA-9021451
Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter
See in Reactome
R-HSA-1989747
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1989776
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-8864307
(
R-HSA-8866907
)
R-HSA-8864307
Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP
See in Reactome
R-HSA-1028815
(
R-HSA-918233
)
R-HSA-1028815
Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta
See in Reactome
R-HSA-3697008
(
R-HSA-3214847
)
R-HSA-3697008
Reaction Name: CREBBP acetylates histone H2B, H3, H4
See in Reactome
R-HSA-1989760
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1989770
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-8878220
(
R-HSA-8941856
)
R-HSA-8878220
Reaction Name: RUNX3 binds the NOTCH1 coactivator complex
See in Reactome
R-HSA-1989762
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1980078
(
R-HSA-2122947
)
R-HSA-1980078
Reaction Name: NOTCH1 stimulates HES5 transcription
See in Reactome
R-HSA-4396379
(
R-HSA-2122947
)
R-HSA-4396379
Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter
See in Reactome
R-HSA-9626928
(
R-HSA-9617629
)
R-HSA-1989757
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1368065
(
R-HSA-1989781;
R-HSA-400206;
R-HSA-400253;
R-HSA-9707616
)
R-HSA-1183058
(
R-HSA-381340
)
R-HSA-9622572
(
R-HSA-9614657
)
R-HSA-9622572
Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter
See in Reactome
R-HSA-9761841
()
R-HSA-9761841
Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression
See in Reactome
R-HSA-1989778
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-5617874
(
R-HSA-5617472
)
R-HSA-9760099
()
R-HSA-9760099
Reaction Name: AcK-NFE2L2 binds the GCLC gene
See in Reactome
R-HSA-9760103
()
R-HSA-9760103
Reaction Name: AcK-NFE2L2 binds the GCLM gene
See in Reactome
R-HSA-560472
(
R-HSA-381340
)
R-HSA-560472
Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C)
See in Reactome
R-HSA-1989767
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-8938251
(
R-HSA-8939246
)
R-HSA-8938251
Reaction Name: CSF2 (GM-CSF) gene expression is stimulated by RUNX1 and CREBBP
See in Reactome
R-HSA-1989748
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-4395227
(
R-HSA-1912408
)
R-HSA-4395227
Reaction Name: CCND1:CREBBP binds NOTCH1 promoter
See in Reactome
R-HSA-1989779
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1989759
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1655848
(
R-HSA-1989781;
R-HSA-2426168;
R-HSA-400206
)
R-HSA-1655848
Reaction Name: Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1)
See in Reactome
R-HSA-1235070
(
R-HSA-1234158
)
R-HSA-1235070
Reaction Name: Expression of Erythropoietin (EPO)
See in Reactome
R-HSA-5660660
(
R-HSA-5621575
)
R-HSA-1989752
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1989749
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1989761
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-1989768
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-9604499
(
R-HSA-933541
)
R-HSA-9604499
Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300
See in Reactome
R-HSA-9604664
(
R-HSA-9013695
)
R-HSA-9604664
Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4
See in Reactome
R-HSA-5617896
(
R-HSA-5617472
)
R-HSA-5617896
Reaction Name: Retinoic acid activates HOXD4 chromatin
See in Reactome
R-HSA-9759364
()
R-HSA-9759364
Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression
See in Reactome
R-HSA-3322427
(
R-HSA-201722
)
R-HSA-3322427
Reaction Name: Beta-catenin recruits CBP/p300
See in Reactome
R-HSA-1655826
(
R-HSA-1989781;
R-HSA-2426168;
R-HSA-400206
)
R-HSA-1655826
Reaction Name: Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR)
See in Reactome
R-HSA-1989774
(
R-HSA-1989781;
R-HSA-400206
)
R-HSA-6797993
(
R-HSA-6803204
)
R-HSA-6797993
Reaction Name: TP53 and CREBBP bind BNIP3L gene
See in Reactome
R-HSA-9759186
()
R-HSA-9759186
Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression
See in Reactome
R-HSA-9760081
()
R-HSA-9760081
Reaction Name: CREBBP, EP300 acetylates NFE2L2
See in Reactome
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