MONDO:0002529 |
RAC1 |
P63000 |
3.6.5.2
|
R-HSA-376172
R-HSA-445144
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-9619229
R-HSA-9619229
Reactome Name: Activation of RAC1 downstream of NMDARs
See in Reactome
R-HSA-428540
R-HSA-428543
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-399954
R-HSA-399954
Reactome Name: Sema3A PAK dependent Axon repulsion
See in Reactome
R-HSA-9032845
R-HSA-9032845
Reactome Name: Activated NTRK2 signals through CDK5
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-6798695
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-193648
R-HSA-193648
Reactome Name: NRAGE signals death through JNK
See in Reactome
R-HSA-5625900
R-HSA-5625740
R-HSA-9032759
R-HSA-1257604
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-389359
R-HSA-5627123
R-HSA-399955
R-HSA-399955
Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
See in Reactome
R-HSA-5626467
R-HSA-4420097
R-HSA-5663220
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5687128
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1433557
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-2424491
R-HSA-9013149
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-8875555
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-3928664
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-8848021
R-HSA-1280218
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9675108
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-112316
R-HSA-8875878
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-373760
R-HSA-9032500
R-HSA-9032500
Reactome Name: Activated NTRK2 signals through FYN
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-168249
R-HSA-195258
R-HSA-199991
R-HSA-73887
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-2682334
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-5653656
R-HSA-6806834
R-HSA-195721
R-HSA-2172127
R-HSA-204998
R-HSA-204998
Reactome Name: Cell death signalling via NRAGE, NRIF and NADE
See in Reactome
R-HSA-373755
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Developmental Biology
Neuronal System
Vesicle-mediated transport
Hemostasis
Signal Transduction
|
R-HSA-1011598
(
R-HSA-983231
)
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1433415
(
R-HSA-1433557
)
R-HSA-2029451
(
R-HSA-2029482
)
R-HSA-2029454
(
R-HSA-2029482
)
R-HSA-2029456
(
R-HSA-2029482;
R-HSA-5627123
)
R-HSA-2029465
(
R-HSA-2029482;
R-HSA-4420097;
R-HSA-5663213
)
R-HSA-2029465
Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)
See in Reactome
R-HSA-2029466
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029466
Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin
See in Reactome
R-HSA-2029467
(
R-HSA-2029482
)
R-HSA-2029467
Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO
See in Reactome
R-HSA-2029469
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029469
Reaction Name: p-ERK phosphorylates WAVEs and ABI
See in Reactome
R-HSA-205039
(
R-HSA-193648
)
R-HSA-205039
Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
See in Reactome
R-HSA-205136
(
R-HSA-193648
)
R-HSA-205136
Reaction Name: GTP-bound RAC contributes to JNK activation
See in Reactome
R-HSA-2130194
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2197690
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2316352
(
R-HSA-1445148
)
R-HSA-2316352
Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424476
(
R-HSA-2424491
)
R-HSA-2730840
(
R-HSA-2871796
)
R-HSA-2730856
(
R-HSA-2871796
)
R-HSA-2730889
(
R-HSA-2871796
)
R-HSA-2730889
Reaction Name: Recruitment of PAK to the membrane by binding active RAC1
See in Reactome
R-HSA-376123
(
R-HSA-376172
)
R-HSA-376123
Reaction Name: DSCAM associates with Rac1-GTP:pPAK1
See in Reactome
R-HSA-3858475
(
R-HSA-4086400
)
R-HSA-389348
(
R-HSA-389359
)
R-HSA-389788
(
R-HSA-389359;
R-HSA-5687128
)
R-HSA-389788
Reaction Name: Activation of PAKs by RAC1 and CDC42
See in Reactome
R-HSA-3928612
(
R-HSA-3928662
)
R-HSA-3928612
Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928619
(
R-HSA-3928662
)
R-HSA-3928620
(
R-HSA-3928662
)
R-HSA-3928625
(
R-HSA-3928664
)
R-HSA-3928628
(
R-HSA-3928665
)
R-HSA-3928628
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928633
(
R-HSA-3928664
)
R-HSA-3928633
Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it
See in Reactome
R-HSA-3928640
(
R-HSA-3928664
)
R-HSA-3928641
(
R-HSA-3928664
)
R-HSA-3928642
(
R-HSA-3928665
)
R-HSA-3928642
Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-399928
(
R-HSA-399955
)
R-HSA-399928
Reaction Name: Recruitment of Rnd1 to Plexin A
See in Reactome
R-HSA-399930
(
R-HSA-399954
)
R-HSA-399935
(
R-HSA-399955
)
R-HSA-399935
Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity
See in Reactome
R-HSA-399938
(
R-HSA-399955
)
R-HSA-399939
(
R-HSA-399954
)
R-HSA-399941
(
R-HSA-399955
)
R-HSA-399952
(
R-HSA-399954
)
R-HSA-399952
Reaction Name: Phosphorylation of LIMK-1 by PAK
See in Reactome
R-HSA-400682
(
R-HSA-416550
)
R-HSA-400682
Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D
See in Reactome
R-HSA-4093336
(
R-HSA-3928662
)
R-HSA-4093336
Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-428522
(
R-HSA-428543
)
R-HSA-428535
(
R-HSA-428540
)
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442592
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-442592
Reaction Name: WASPs or WAVEs activate the ARP2/3 complex
See in Reactome
R-HSA-445064
(
R-HSA-445144
)
R-HSA-445072
(
R-HSA-445144
)
R-HSA-445072
Reaction Name: Interaction of PAK1 with Rac1-GTP
See in Reactome
R-HSA-451347
(
R-HSA-376172
)
R-HSA-451366
(
R-HSA-376172
)
R-HSA-5218827
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218827
Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1
See in Reactome
R-HSA-5218839
(
R-HSA-4420097
)
R-HSA-5218839
Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1
See in Reactome
R-HSA-5218841
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R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218841
Reaction Name: NADPH oxidase 2 generates superoxide from oxygen
See in Reactome
R-HSA-5218850
(
R-HSA-4420097
)
R-HSA-5218850
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-5357445
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357472
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357483
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5626469
(
R-HSA-5626467
)
R-HSA-5626469
Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs
See in Reactome
R-HSA-5626507
(
R-HSA-5626467
)
R-HSA-5626507
Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin
See in Reactome
R-HSA-5626549
(
R-HSA-5626467
)
R-HSA-5627775
(
R-HSA-5627123;
R-HSA-5687128
)
R-HSA-5627775
Reaction Name: Autophosphorylation of PAK1,2,3
See in Reactome
R-HSA-5663232
(
R-HSA-5663220
)
R-HSA-5665659
(
R-HSA-5663220
)
R-HSA-5665659
Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin
See in Reactome
R-HSA-5665802
(
R-HSA-5663220
)
R-HSA-5665802
Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin
See in Reactome
R-HSA-5665809
(
R-HSA-5663220
)
R-HSA-5665809
Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments
See in Reactome
R-HSA-5668714
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R-HSA-5668599
)
R-HSA-5668718
(
R-HSA-5668599
)
R-HSA-5668718
Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen
See in Reactome
R-HSA-5668731
(
R-HSA-5668599
)
R-HSA-5668731
Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen
See in Reactome
R-HSA-5668735
(
R-HSA-5668599
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5672304
(
R-HSA-5626467
)
R-HSA-5672304
Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1
See in Reactome
R-HSA-5672329
(
R-HSA-5626467
)
R-HSA-5672329
Reaction Name: IQGAP1 binds CLIP1 and microtubules
See in Reactome
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8848618
(
R-HSA-8849471
)
R-HSA-8848618
Reaction Name: Activation of RAC1 by the PXN:CRK complex
See in Reactome
R-HSA-8875591
(
R-HSA-8875555
)
R-HSA-8951586
(
R-HSA-4420097
)
R-HSA-8951586
Reaction Name: p-VAV family:PIP3 binds RAC1:GDP
See in Reactome
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981926
(
R-HSA-5627123
)
R-HSA-8981931
(
R-HSA-5627123
)
R-HSA-9013143
(
R-HSA-9013149
)
R-HSA-9013144
(
R-HSA-9013149
)
R-HSA-9013144
Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9013147
(
R-HSA-9013149
)
R-HSA-9013147
Reaction Name: RAC1 GDIs block activation of RAC1
See in Reactome
R-HSA-9032798
(
R-HSA-9032759
)
R-HSA-9033292
(
R-HSA-9032845
)
R-HSA-9033292
Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1
See in Reactome
R-HSA-9619803
(
R-HSA-9619229
)
R-HSA-9691168
(
R-HSA-9013149
)
R-HSA-9691168
Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane
See in Reactome
R-HSA-9691174
(
R-HSA-9013149
)
R-HSA-9691174
Reaction Name: RAC1 binds effectors at the ER membrane
See in Reactome
|
MONDO:0005012 |
RAC1 |
P63000 |
3.6.5.2
|
R-HSA-376172
R-HSA-445144
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-9619229
R-HSA-9619229
Reactome Name: Activation of RAC1 downstream of NMDARs
See in Reactome
R-HSA-428540
R-HSA-428543
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-399954
R-HSA-399954
Reactome Name: Sema3A PAK dependent Axon repulsion
See in Reactome
R-HSA-9032845
R-HSA-9032845
Reactome Name: Activated NTRK2 signals through CDK5
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-6798695
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-193648
R-HSA-193648
Reactome Name: NRAGE signals death through JNK
See in Reactome
R-HSA-5625900
R-HSA-5625740
R-HSA-9032759
R-HSA-1257604
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-389359
R-HSA-5627123
R-HSA-399955
R-HSA-399955
Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
See in Reactome
R-HSA-5626467
R-HSA-4420097
R-HSA-5663220
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5687128
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1433557
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-2424491
R-HSA-9013149
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-8875555
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-3928664
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-8848021
R-HSA-1280218
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9675108
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-112316
R-HSA-8875878
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-373760
R-HSA-9032500
R-HSA-9032500
Reactome Name: Activated NTRK2 signals through FYN
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-168249
R-HSA-195258
R-HSA-199991
R-HSA-73887
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-2682334
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-5653656
R-HSA-6806834
R-HSA-195721
R-HSA-2172127
R-HSA-204998
R-HSA-204998
Reactome Name: Cell death signalling via NRAGE, NRIF and NADE
See in Reactome
R-HSA-373755
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Developmental Biology
Neuronal System
Vesicle-mediated transport
Hemostasis
Signal Transduction
|
R-HSA-1011598
(
R-HSA-983231
)
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1433415
(
R-HSA-1433557
)
R-HSA-2029451
(
R-HSA-2029482
)
R-HSA-2029454
(
R-HSA-2029482
)
R-HSA-2029456
(
R-HSA-2029482;
R-HSA-5627123
)
R-HSA-2029465
(
R-HSA-2029482;
R-HSA-4420097;
R-HSA-5663213
)
R-HSA-2029465
Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)
See in Reactome
R-HSA-2029466
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029466
Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin
See in Reactome
R-HSA-2029467
(
R-HSA-2029482
)
R-HSA-2029467
Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO
See in Reactome
R-HSA-2029469
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029469
Reaction Name: p-ERK phosphorylates WAVEs and ABI
See in Reactome
R-HSA-205039
(
R-HSA-193648
)
R-HSA-205039
Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
See in Reactome
R-HSA-205136
(
R-HSA-193648
)
R-HSA-205136
Reaction Name: GTP-bound RAC contributes to JNK activation
See in Reactome
R-HSA-2130194
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2197690
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2316352
(
R-HSA-1445148
)
R-HSA-2316352
Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424476
(
R-HSA-2424491
)
R-HSA-2730840
(
R-HSA-2871796
)
R-HSA-2730856
(
R-HSA-2871796
)
R-HSA-2730889
(
R-HSA-2871796
)
R-HSA-2730889
Reaction Name: Recruitment of PAK to the membrane by binding active RAC1
See in Reactome
R-HSA-376123
(
R-HSA-376172
)
R-HSA-376123
Reaction Name: DSCAM associates with Rac1-GTP:pPAK1
See in Reactome
R-HSA-3858475
(
R-HSA-4086400
)
R-HSA-389348
(
R-HSA-389359
)
R-HSA-389788
(
R-HSA-389359;
R-HSA-5687128
)
R-HSA-389788
Reaction Name: Activation of PAKs by RAC1 and CDC42
See in Reactome
R-HSA-3928612
(
R-HSA-3928662
)
R-HSA-3928612
Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928619
(
R-HSA-3928662
)
R-HSA-3928620
(
R-HSA-3928662
)
R-HSA-3928625
(
R-HSA-3928664
)
R-HSA-3928628
(
R-HSA-3928665
)
R-HSA-3928628
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928633
(
R-HSA-3928664
)
R-HSA-3928633
Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it
See in Reactome
R-HSA-3928640
(
R-HSA-3928664
)
R-HSA-3928641
(
R-HSA-3928664
)
R-HSA-3928642
(
R-HSA-3928665
)
R-HSA-3928642
Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-399928
(
R-HSA-399955
)
R-HSA-399928
Reaction Name: Recruitment of Rnd1 to Plexin A
See in Reactome
R-HSA-399930
(
R-HSA-399954
)
R-HSA-399935
(
R-HSA-399955
)
R-HSA-399935
Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity
See in Reactome
R-HSA-399938
(
R-HSA-399955
)
R-HSA-399939
(
R-HSA-399954
)
R-HSA-399941
(
R-HSA-399955
)
R-HSA-399952
(
R-HSA-399954
)
R-HSA-399952
Reaction Name: Phosphorylation of LIMK-1 by PAK
See in Reactome
R-HSA-400682
(
R-HSA-416550
)
R-HSA-400682
Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D
See in Reactome
R-HSA-4093336
(
R-HSA-3928662
)
R-HSA-4093336
Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-428522
(
R-HSA-428543
)
R-HSA-428535
(
R-HSA-428540
)
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442592
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-442592
Reaction Name: WASPs or WAVEs activate the ARP2/3 complex
See in Reactome
R-HSA-445064
(
R-HSA-445144
)
R-HSA-445072
(
R-HSA-445144
)
R-HSA-445072
Reaction Name: Interaction of PAK1 with Rac1-GTP
See in Reactome
R-HSA-451347
(
R-HSA-376172
)
R-HSA-451366
(
R-HSA-376172
)
R-HSA-5218827
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218827
Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1
See in Reactome
R-HSA-5218839
(
R-HSA-4420097
)
R-HSA-5218839
Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1
See in Reactome
R-HSA-5218841
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218841
Reaction Name: NADPH oxidase 2 generates superoxide from oxygen
See in Reactome
R-HSA-5218850
(
R-HSA-4420097
)
R-HSA-5218850
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-5357445
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357472
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357483
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5626469
(
R-HSA-5626467
)
R-HSA-5626469
Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs
See in Reactome
R-HSA-5626507
(
R-HSA-5626467
)
R-HSA-5626507
Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin
See in Reactome
R-HSA-5626549
(
R-HSA-5626467
)
R-HSA-5627775
(
R-HSA-5627123;
R-HSA-5687128
)
R-HSA-5627775
Reaction Name: Autophosphorylation of PAK1,2,3
See in Reactome
R-HSA-5663232
(
R-HSA-5663220
)
R-HSA-5665659
(
R-HSA-5663220
)
R-HSA-5665659
Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin
See in Reactome
R-HSA-5665802
(
R-HSA-5663220
)
R-HSA-5665802
Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin
See in Reactome
R-HSA-5665809
(
R-HSA-5663220
)
R-HSA-5665809
Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments
See in Reactome
R-HSA-5668714
(
R-HSA-5668599
)
R-HSA-5668718
(
R-HSA-5668599
)
R-HSA-5668718
Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen
See in Reactome
R-HSA-5668731
(
R-HSA-5668599
)
R-HSA-5668731
Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen
See in Reactome
R-HSA-5668735
(
R-HSA-5668599
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5672304
(
R-HSA-5626467
)
R-HSA-5672304
Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1
See in Reactome
R-HSA-5672329
(
R-HSA-5626467
)
R-HSA-5672329
Reaction Name: IQGAP1 binds CLIP1 and microtubules
See in Reactome
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8848618
(
R-HSA-8849471
)
R-HSA-8848618
Reaction Name: Activation of RAC1 by the PXN:CRK complex
See in Reactome
R-HSA-8875591
(
R-HSA-8875555
)
R-HSA-8951586
(
R-HSA-4420097
)
R-HSA-8951586
Reaction Name: p-VAV family:PIP3 binds RAC1:GDP
See in Reactome
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981926
(
R-HSA-5627123
)
R-HSA-8981931
(
R-HSA-5627123
)
R-HSA-9013143
(
R-HSA-9013149
)
R-HSA-9013144
(
R-HSA-9013149
)
R-HSA-9013144
Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9013147
(
R-HSA-9013149
)
R-HSA-9013147
Reaction Name: RAC1 GDIs block activation of RAC1
See in Reactome
R-HSA-9032798
(
R-HSA-9032759
)
R-HSA-9033292
(
R-HSA-9032845
)
R-HSA-9033292
Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1
See in Reactome
R-HSA-9619803
(
R-HSA-9619229
)
R-HSA-9691168
(
R-HSA-9013149
)
R-HSA-9691168
Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane
See in Reactome
R-HSA-9691174
(
R-HSA-9013149
)
R-HSA-9691174
Reaction Name: RAC1 binds effectors at the ER membrane
See in Reactome
|
MONDO:0005036 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0005061 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0005138 |
ROCK1 |
Q13464 |
2.7.11.1
|
R-HSA-4420097
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-111465
R-HSA-111465
Reactome Name: Apoptotic cleavage of cellular proteins
See in Reactome
R-HSA-9696264
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-9013026
R-HSA-9013407
R-HSA-6798695
R-HSA-9013422
R-HSA-8980692
|
R-HSA-162582
R-HSA-195258
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-400685
R-HSA-9012999
R-HSA-194138
R-HSA-388396
R-HSA-109581
R-HSA-168256
R-HSA-194315
R-HSA-9675108
R-HSA-75153
R-HSA-9706574
R-HSA-5357801
R-HSA-168249
R-HSA-372790
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-2682334
R-HSA-1266738
|
Signal Transduction
Immune System
Programmed Cell Death
Developmental Biology
|
R-HSA-201611
(
R-HSA-111465
)
R-HSA-201611
Reaction Name: Caspase-mediated cleavage of Rock-1
See in Reactome
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013024
(
R-HSA-9013026
)
R-HSA-9013024
Reaction Name: RHOB binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9018778
(
R-HSA-9013422
)
R-HSA-9018778
Reaction Name: RHOBTB1 binds interacting proteins at the endosome membrane
See in Reactome
R-HSA-9680443
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-9696268
(
R-HSA-9696264
)
|
MONDO:0005335 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
NRAS |
P01111 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-6798695
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-202733;
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392;
R-HSA-881907
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
PTPRJ |
Q12913 |
3.1.3.48
|
R-HSA-6807004
R-HSA-6807004
Reactome Name: Negative regulation of MET activity
See in Reactome
R-HSA-6798695
R-HSA-9706369
R-HSA-202427
R-HSA-202427
Reactome Name: Phosphorylation of CD3 and TCR zeta chains
See in Reactome
|
R-HSA-6806834
R-HSA-168256
R-HSA-168249
R-HSA-202403
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9607240
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-1280218
R-HSA-162582
|
Immune System
Signal Transduction
|
R-HSA-202214
(
R-HSA-202427
)
R-HSA-202214
Reaction Name: Dephosphorylation of Lck-pY505 by CD45
See in Reactome
R-HSA-202233
(
R-HSA-202427
)
R-HSA-6799350
(
R-HSA-6798695
)
R-HSA-6799350
Reaction Name: Exocytosis of specific granule membrane proteins
See in Reactome
R-HSA-6807008
(
R-HSA-6807004
)
R-HSA-9698408
(
R-HSA-9706369
)
R-HSA-9698408
Reaction Name: PTPRJ dephosphorylates active FLT3
See in Reactome
|
MONDO:0007088 |
PSEN1 |
P49768 |
3.4.23.-
|
R-HSA-9013507
R-HSA-9013507
Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus
See in Reactome
R-HSA-193692
R-HSA-193692
Reactome Name: Regulated proteolysis of p75NTR
See in Reactome
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-1474228
R-HSA-1474228
Reactome Name: Degradation of the extracellular matrix
See in Reactome
R-HSA-205043
R-HSA-205043
Reactome Name: NRIF signals cell death from the nucleus
See in Reactome
R-HSA-9013700
R-HSA-9013700
Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus
See in Reactome
R-HSA-6798695
R-HSA-2122948
R-HSA-2122948
Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus
See in Reactome
R-HSA-9017802
R-HSA-9017802
Reactome Name: Noncanonical activation of NOTCH3
See in Reactome
R-HSA-1251985
R-HSA-2979096
R-HSA-2979096
Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus
See in Reactome
|
R-HSA-204998
R-HSA-204998
Reactome Name: Cell death signalling via NRAGE, NRIF and NADE
See in Reactome
R-HSA-1980143
R-HSA-9012852
R-HSA-1980145
R-HSA-168249
R-HSA-168256
R-HSA-9675108
R-HSA-9013694
R-HSA-157118
R-HSA-1474244
R-HSA-1474244
Reactome Name: Extracellular matrix organization
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-73887
R-HSA-1236394
R-HSA-422475
R-HSA-2682334
R-HSA-1266738
|
Immune System
Extracellular matrix organization
Signal Transduction
Developmental Biology
|
R-HSA-1251997
(
R-HSA-1251985
)
R-HSA-1251997
Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex
See in Reactome
R-HSA-157353
(
R-HSA-2122948
)
R-HSA-157353
Reaction Name: NEXT1 is cleaved to produce NICD1
See in Reactome
R-HSA-157640
(
R-HSA-2979096
)
R-HSA-157640
Reaction Name: NEXT2 is cleaved to produce NICD2
See in Reactome
R-HSA-193682
(
R-HSA-193692
)
R-HSA-193682
Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain
See in Reactome
R-HSA-1980109
(
R-HSA-2122948
)
R-HSA-1980109
Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1
See in Reactome
R-HSA-1980112
(
R-HSA-2122948
)
R-HSA-1980112
Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1
See in Reactome
R-HSA-205112
(
R-HSA-205043
)
R-HSA-205112
Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6
See in Reactome
R-HSA-2534206
(
R-HSA-1474228
)
R-HSA-2534206
Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase)
See in Reactome
R-HSA-2974731
(
R-HSA-2979096
)
R-HSA-2974731
Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2
See in Reactome
R-HSA-3928656
(
R-HSA-3928665
)
R-HSA-6798739
(
R-HSA-6798695
)
R-HSA-6798739
Reaction Name: Exocytosis of azurophil granule membrane proteins
See in Reactome
R-HSA-9013361
(
R-HSA-9013507
)
R-HSA-9013361
Reaction Name: NEXT3 is cleaved to produce NICD3
See in Reactome
R-HSA-9017817
(
R-HSA-9013507;
R-HSA-9017802
)
R-HSA-9017817
Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3
See in Reactome
R-HSA-9604294
(
R-HSA-9013700
)
R-HSA-9604294
Reaction Name: Gamma-secretase cleaves NOTCH4
See in Reactome
|
MONDO:0007088 |
VCP |
P55072 |
3.6.4.6
|
R-HSA-3371511
R-HSA-9646399
R-HSA-110320
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5358346
R-HSA-9013407
R-HSA-532668
R-HSA-532668
Reactome Name: N-glycan trimming in the ER and Calnexin/Calreticulin cycle
See in Reactome
R-HSA-6798695
R-HSA-8876725
R-HSA-8866654
R-HSA-8866654
Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins
See in Reactome
R-HSA-5689877
|
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-382551
R-HSA-5358351
R-HSA-8953897
R-HSA-2262752
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-9612973
R-HSA-168249
R-HSA-9663891
R-HSA-392499
R-HSA-110313
R-HSA-110313
Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
See in Reactome
R-HSA-8852135
R-HSA-1632852
R-HSA-5688426
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-73894
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-162582
R-HSA-73893
|
Immune System
Transport of small molecules
Cellular responses to stimuli
Autophagy
Metabolism of proteins
DNA Repair
Signal Transduction
|
R-HSA-5324632
(
R-HSA-3371511
)
R-HSA-5324632
Reaction Name: Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates
See in Reactome
R-HSA-5362412
(
R-HSA-5358346
)
R-HSA-5362412
Reaction Name: SYVN1 ubiquitinates Hh C-terminal fragments
See in Reactome
R-HSA-5362441
(
R-HSA-5358346
)
R-HSA-5362441
Reaction Name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane
See in Reactome
R-HSA-5362459
(
R-HSA-5358346
)
R-HSA-5362459
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol
See in Reactome
R-HSA-5654985
(
R-HSA-110320
)
R-HSA-5654985
Reaction Name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH
See in Reactome
R-HSA-5654989
(
R-HSA-110320
)
R-HSA-5654989
Reaction Name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA
See in Reactome
R-HSA-5688834
(
R-HSA-5689877
)
R-HSA-6781953
(
R-HSA-5689896
)
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-8850594
(
R-HSA-532668
)
R-HSA-8850594
Reaction Name: Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins
See in Reactome
R-HSA-8866542
(
R-HSA-382556
)
R-HSA-8866542
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol
See in Reactome
R-HSA-8866546
(
R-HSA-382556
)
R-HSA-8866546
Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR
See in Reactome
R-HSA-8866551
(
R-HSA-382556
)
R-HSA-8866551
Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation
See in Reactome
R-HSA-8932276
(
R-HSA-8876725
)
R-HSA-8932276
Reaction Name: VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP
See in Reactome
R-HSA-8943080
(
R-HSA-8866654
)
R-HSA-8943080
Reaction Name: TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11
See in Reactome
R-HSA-8943083
(
R-HSA-8866654
)
R-HSA-8943083
Reaction Name: US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9646347
(
R-HSA-9646399
)
R-HSA-9646347
Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1
See in Reactome
R-HSA-9646354
(
R-HSA-9646399
)
R-HSA-9646354
Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex
See in Reactome
R-HSA-9755507
()
R-HSA-9755507
Reaction Name: UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex
See in Reactome
R-HSA-9758088
()
R-HSA-9758088
Reaction Name: UBXN7 binds VCP hexamer:UBF1:NPLOC4
See in Reactome
R-HSA-9758090
()
R-HSA-9758090
Reaction Name: Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation
See in Reactome
|
MONDO:0007847 |
ASAH1 |
Q13510 |
3.5.1.23
3.5.1.-
|
R-HSA-6798695
R-HSA-1660662
|
R-HSA-556833
R-HSA-168249
R-HSA-1430728
R-HSA-168256
R-HSA-428157
|
Metabolism
Immune System
|
R-HSA-1606602
(
R-HSA-1660662
)
R-HSA-1606602
Reaction Name: Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome)
See in Reactome
R-HSA-6798745
(
R-HSA-6798695
)
R-HSA-6798745
Reaction Name: Exocytosis of tertiary granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
|
MONDO:0007854 |
CTSB |
P07858 |
3.4.22.1
|
R-HSA-1679131
R-HSA-1679131
Reactome Name: Trafficking and processing of endosomal TLR
See in Reactome
R-HSA-2022090
R-HSA-2022090
Reactome Name: Assembly of collagen fibrils and other multimeric structures
See in Reactome
R-HSA-2132295
R-HSA-2132295
Reactome Name: MHC class II antigen presentation
See in Reactome
R-HSA-6798695
R-HSA-1442490
|
R-HSA-168249
R-HSA-168256
R-HSA-1474228
R-HSA-1474228
Reactome Name: Degradation of the extracellular matrix
See in Reactome
R-HSA-168898
R-HSA-1474244
R-HSA-1474244
Reactome Name: Extracellular matrix organization
See in Reactome
R-HSA-1474290
R-HSA-1280218
|
Immune System
Extracellular matrix organization
|
R-HSA-1678920
(
R-HSA-1679131
)
R-HSA-2130349
(
R-HSA-2132295
)
R-HSA-2130504
(
R-HSA-2132295
)
R-HSA-2130706
(
R-HSA-2132295
)
R-HSA-2130706
Reaction Name: MHC class II antigen processing
See in Reactome
R-HSA-2168923
(
R-HSA-1442490;
R-HSA-1474228
)
R-HSA-2168923
Reaction Name: Collagen type XVIII endostatin release
See in Reactome
R-HSA-2213200
(
R-HSA-2022090
)
R-HSA-2213200
Reaction Name: Release of endostatin-like peptides
See in Reactome
R-HSA-2471621
(
R-HSA-1442490;
R-HSA-1474228
)
R-HSA-2471621
Reaction Name: Endostatin degradation by cathepsins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
|
MONDO:0008045 |
ASAH1 |
Q13510 |
3.5.1.23
3.5.1.-
|
R-HSA-6798695
R-HSA-1660662
|
R-HSA-556833
R-HSA-168249
R-HSA-1430728
R-HSA-168256
R-HSA-428157
|
Metabolism
Immune System
|
R-HSA-1606602
(
R-HSA-1660662
)
R-HSA-1606602
Reaction Name: Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome)
See in Reactome
R-HSA-6798745
(
R-HSA-6798695
)
R-HSA-6798745
Reaction Name: Exocytosis of tertiary granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
|
MONDO:0008090 |
ELANE |
P08246 |
3.4.21.37
|
R-HSA-5620971
R-HSA-977606
R-HSA-977606
Reactome Name: Regulation of Complement cascade
See in Reactome
R-HSA-1474228
R-HSA-1474228
Reactome Name: Degradation of the extracellular matrix
See in Reactome
R-HSA-1442490
R-HSA-1592389
R-HSA-1592389
Reactome Name: Activation of Matrix Metalloproteinases
See in Reactome
R-HSA-6803157
R-HSA-6798695
|
R-HSA-168249
R-HSA-168256
R-HSA-5218859
R-HSA-5357801
R-HSA-1474244
R-HSA-1474244
Reactome Name: Extracellular matrix organization
See in Reactome
R-HSA-166658
|
Immune System
Programmed Cell Death
Extracellular matrix organization
|
R-HSA-1566962
(
R-HSA-1474228
)
R-HSA-1566962
Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases
See in Reactome
R-HSA-1592270
(
R-HSA-1474228
)
R-HSA-1592270
Reaction Name: NID1 degradation by MMP1, 9, 12, ELANE
See in Reactome
R-HSA-1592316
(
R-HSA-1474228;
R-HSA-1592389
)
R-HSA-1592398
(
R-HSA-1474228;
R-HSA-1592389
)
R-HSA-1604712
(
R-HSA-1474228;
R-HSA-1592389
)
R-HSA-1604712
Reaction Name: Initial activation of proMMP7 by trypsin
See in Reactome
R-HSA-2482180
(
R-HSA-1442490;
R-HSA-1474228
)
R-HSA-2482180
Reaction Name: Collagen type VIII degradation by ELANE
See in Reactome
R-HSA-2514823
(
R-HSA-1474228
)
R-HSA-2514823
Reaction Name: Fibrillin-1 degradation by ELANE
See in Reactome
R-HSA-6798749
(
R-HSA-6798695
)
R-HSA-6798749
Reaction Name: Exocytosis of specific granule lumen proteins
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6813659
(
R-HSA-6803157
)
R-HSA-6813659
Reaction Name: ELANE, CTSG or PRTN3 binds bacteria
See in Reactome
R-HSA-8852716
(
R-HSA-977606
)
R-HSA-9710106
(
R-HSA-5620971
)
|
MONDO:0008093 |
NRAS |
P01111 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-6798695
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-202733;
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392;
R-HSA-881907
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
|
MONDO:0008097 |
NRAS |
P01111 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-6798695
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-202733;
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392;
R-HSA-881907
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
|
MONDO:0008145 |
IDH1 |
O75874 |
1.1.1.42
|
R-HSA-6798695
R-HSA-9033241
R-HSA-389542
|
R-HSA-168256
R-HSA-9609507
R-HSA-8978934
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-168249
R-HSA-1430728
|
Immune System
Protein localization
Metabolism
|
R-HSA-389540
(
R-HSA-389542
)
R-HSA-389540
Reaction Name: isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
See in Reactome
R-HSA-389550
(
R-HSA-389542
)
R-HSA-389550
Reaction Name: isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
See in Reactome
R-HSA-6798745
(
R-HSA-6798695
)
R-HSA-6798745
Reaction Name: Exocytosis of tertiary granule lumen proteins
See in Reactome
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-9033233
(
R-HSA-9033241
)
R-HSA-9033233
(
R-HSA-9033241
)
R-HSA-9033233
Reaction Name: PEX5S,L binds cargo proteins containing PTS1
See in Reactome
R-HSA-9033235
(
R-HSA-9033241
)
R-HSA-9033235
(
R-HSA-9033241
)
R-HSA-9033235
Reaction Name: Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix
See in Reactome
R-HSA-9033236
(
R-HSA-9033241
)
R-HSA-9033236
(
R-HSA-9033241
)
R-HSA-9033236
Reaction Name: PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)
See in Reactome
R-HSA-9761844
()
R-HSA-9761844
Reaction Name: NFE2L2-dependent IDH1 gene expression
See in Reactome
|
MONDO:0008178 |
VCP |
P55072 |
3.6.4.6
|
R-HSA-3371511
R-HSA-9646399
R-HSA-110320
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5358346
R-HSA-9013407
R-HSA-532668
R-HSA-532668
Reactome Name: N-glycan trimming in the ER and Calnexin/Calreticulin cycle
See in Reactome
R-HSA-6798695
R-HSA-8876725
R-HSA-8866654
R-HSA-8866654
Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins
See in Reactome
R-HSA-5689877
|
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-382551
R-HSA-5358351
R-HSA-8953897
R-HSA-2262752
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-9612973
R-HSA-168249
R-HSA-9663891
R-HSA-392499
R-HSA-110313
R-HSA-110313
Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
See in Reactome
R-HSA-8852135
R-HSA-1632852
R-HSA-5688426
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-73894
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-162582
R-HSA-73893
|
Immune System
Transport of small molecules
Cellular responses to stimuli
Autophagy
Metabolism of proteins
DNA Repair
Signal Transduction
|
R-HSA-5324632
(
R-HSA-3371511
)
R-HSA-5324632
Reaction Name: Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates
See in Reactome
R-HSA-5362412
(
R-HSA-5358346
)
R-HSA-5362412
Reaction Name: SYVN1 ubiquitinates Hh C-terminal fragments
See in Reactome
R-HSA-5362441
(
R-HSA-5358346
)
R-HSA-5362441
Reaction Name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane
See in Reactome
R-HSA-5362459
(
R-HSA-5358346
)
R-HSA-5362459
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol
See in Reactome
R-HSA-5654985
(
R-HSA-110320
)
R-HSA-5654985
Reaction Name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH
See in Reactome
R-HSA-5654989
(
R-HSA-110320
)
R-HSA-5654989
Reaction Name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA
See in Reactome
R-HSA-5688834
(
R-HSA-5689877
)
R-HSA-6781953
(
R-HSA-5689896
)
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-8850594
(
R-HSA-532668
)
R-HSA-8850594
Reaction Name: Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins
See in Reactome
R-HSA-8866542
(
R-HSA-382556
)
R-HSA-8866542
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol
See in Reactome
R-HSA-8866546
(
R-HSA-382556
)
R-HSA-8866546
Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR
See in Reactome
R-HSA-8866551
(
R-HSA-382556
)
R-HSA-8866551
Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation
See in Reactome
R-HSA-8932276
(
R-HSA-8876725
)
R-HSA-8932276
Reaction Name: VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP
See in Reactome
R-HSA-8943080
(
R-HSA-8866654
)
R-HSA-8943080
Reaction Name: TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11
See in Reactome
R-HSA-8943083
(
R-HSA-8866654
)
R-HSA-8943083
Reaction Name: US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9646347
(
R-HSA-9646399
)
R-HSA-9646347
Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1
See in Reactome
R-HSA-9646354
(
R-HSA-9646399
)
R-HSA-9646354
Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex
See in Reactome
R-HSA-9755507
()
R-HSA-9755507
Reaction Name: UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex
See in Reactome
R-HSA-9758088
()
R-HSA-9758088
Reaction Name: UBXN7 binds VCP hexamer:UBF1:NPLOC4
See in Reactome
R-HSA-9758090
()
R-HSA-9758090
Reaction Name: Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation
See in Reactome
|
MONDO:0008226 |
CTSC |
P53634 |
3.4.14.1
|
R-HSA-6798695
R-HSA-5694530
R-HSA-204005
R-HSA-204005
Reactome Name: COPII-mediated vesicle transport
See in Reactome
R-HSA-2132295
R-HSA-2132295
Reactome Name: MHC class II antigen presentation
See in Reactome
|
R-HSA-168249
R-HSA-168256
R-HSA-392499
R-HSA-199991
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-199977
R-HSA-199977
Reactome Name: ER to Golgi Anterograde Transport
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-948021
R-HSA-948021
Reactome Name: Transport to the Golgi and subsequent modification
See in Reactome
R-HSA-1280218
R-HSA-5653656
|
Immune System
Metabolism of proteins
Vesicle-mediated transport
|
R-HSA-203973
(
R-HSA-204005
)
R-HSA-204008
(
R-HSA-204005
)
R-HSA-204008
Reaction Name: SEC31:SEC13 and v-SNARE recruitment
See in Reactome
R-HSA-2130349
(
R-HSA-2132295
)
R-HSA-2130504
(
R-HSA-2132295
)
R-HSA-2130706
(
R-HSA-2132295
)
R-HSA-2130706
Reaction Name: MHC class II antigen processing
See in Reactome
R-HSA-5694409
(
R-HSA-204005
)
R-HSA-5694417
(
R-HSA-204005
)
R-HSA-5694417
Reaction Name: SEC16 complex binds SAR1B:GTP:SEC23:SEC24
See in Reactome
R-HSA-5694418
(
R-HSA-204005
)
R-HSA-5694418
Reaction Name: RAB1:GTP binds USO1 and GORASP1:GOLGA2
See in Reactome
R-HSA-5694428
(
R-HSA-5694530
)
R-HSA-5694428
Reaction Name: LMAN family proteins bind glycosylated cargo
See in Reactome
R-HSA-5694439
(
R-HSA-204005
)
R-HSA-5694439
Reaction Name: COPII coat binds TRAPPCII and RAB1:GDP
See in Reactome
R-HSA-5694441
(
R-HSA-204005
)
R-HSA-5694446
(
R-HSA-204005
)
R-HSA-5694446
Reaction Name: BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle
See in Reactome
R-HSA-5694522
(
R-HSA-204005;
R-HSA-5694530
)
R-HSA-5694522
Reaction Name: Inner coat assembly and cargo binding
See in Reactome
R-HSA-5694527
(
R-HSA-204005
)
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
|
MONDO:0008243 |
MONDO:0008243
Disease Name: Pick disease
OMIM id: OMIM:172700
Orphanet id: Orphanet:282
All associated enzymes in DAR:
PSEN1
. The disease is also associated to other non-enzyme proteins (not in DAR).
PSEN1 |
P49768 |
3.4.23.-
|
R-HSA-9013507
R-HSA-9013507
Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus
See in Reactome
R-HSA-193692
R-HSA-193692
Reactome Name: Regulated proteolysis of p75NTR
See in Reactome
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-1474228
R-HSA-1474228
Reactome Name: Degradation of the extracellular matrix
See in Reactome
R-HSA-205043
R-HSA-205043
Reactome Name: NRIF signals cell death from the nucleus
See in Reactome
R-HSA-9013700
R-HSA-9013700
Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus
See in Reactome
R-HSA-6798695
R-HSA-2122948
R-HSA-2122948
Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus
See in Reactome
R-HSA-9017802
R-HSA-9017802
Reactome Name: Noncanonical activation of NOTCH3
See in Reactome
R-HSA-1251985
R-HSA-2979096
R-HSA-2979096
Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus
See in Reactome
|
R-HSA-204998
R-HSA-204998
Reactome Name: Cell death signalling via NRAGE, NRIF and NADE
See in Reactome
R-HSA-1980143
R-HSA-9012852
R-HSA-1980145
R-HSA-168249
R-HSA-168256
R-HSA-9675108
R-HSA-9013694
R-HSA-157118
R-HSA-1474244
R-HSA-1474244
Reactome Name: Extracellular matrix organization
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-73887
R-HSA-1236394
R-HSA-422475
R-HSA-2682334
R-HSA-1266738
|
Immune System
Extracellular matrix organization
Signal Transduction
Developmental Biology
|
R-HSA-1251997
(
R-HSA-1251985
)
R-HSA-1251997
Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex
See in Reactome
R-HSA-157353
(
R-HSA-2122948
)
R-HSA-157353
Reaction Name: NEXT1 is cleaved to produce NICD1
See in Reactome
R-HSA-157640
(
R-HSA-2979096
)
R-HSA-157640
Reaction Name: NEXT2 is cleaved to produce NICD2
See in Reactome
R-HSA-193682
(
R-HSA-193692
)
R-HSA-193682
Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain
See in Reactome
R-HSA-1980109
(
R-HSA-2122948
)
R-HSA-1980109
Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1
See in Reactome
R-HSA-1980112
(
R-HSA-2122948
)
R-HSA-1980112
Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1
See in Reactome
R-HSA-205112
(
R-HSA-205043
)
R-HSA-205112
Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6
See in Reactome
R-HSA-2534206
(
R-HSA-1474228
)
R-HSA-2534206
Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase)
See in Reactome
R-HSA-2974731
(
R-HSA-2979096
)
R-HSA-2974731
Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2
See in Reactome
R-HSA-3928656
(
R-HSA-3928665
)
R-HSA-6798739
(
R-HSA-6798695
)
R-HSA-6798739
Reaction Name: Exocytosis of azurophil granule membrane proteins
See in Reactome
R-HSA-9013361
(
R-HSA-9013507
)
R-HSA-9013361
Reaction Name: NEXT3 is cleaved to produce NICD3
See in Reactome
R-HSA-9017817
(
R-HSA-9013507;
R-HSA-9017802
)
R-HSA-9017817
Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3
See in Reactome
R-HSA-9604294
(
R-HSA-9013700
)
R-HSA-9604294
Reaction Name: Gamma-secretase cleaves NOTCH4
See in Reactome
|
MONDO:0008379 |
IMPDH1 |
P20839 |
1.1.1.205
|
R-HSA-6798695
R-HSA-73817
R-HSA-73817
Reactome Name: Purine ribonucleoside monophosphate biosynthesis
See in Reactome
|
R-HSA-1430728
R-HSA-168256
R-HSA-168249
R-HSA-15869
R-HSA-8956320
|
Metabolism
Immune System
|
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-73794
(
R-HSA-73817
)
R-HSA-73794
Reaction Name: IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]
See in Reactome
R-HSA-9678749
(
R-HSA-73817
)
R-HSA-9678749
Reaction Name: IMPDH tetramers binds IMPDH inhibitors
See in Reactome
|
MONDO:0008436 |
ADA2 |
Q9NZK5 |
3.5.4.4
|
R-HSA-6798695
R-HSA-5683826
|
R-HSA-168256
R-HSA-168249
R-HSA-392499
|
Immune System
Metabolism of proteins
|
R-HSA-5693346
(
R-HSA-5683826
)
R-HSA-5693346
Reaction Name: CECRI deaminates Ade-Rib to Ino
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
|
MONDO:0008566 |
NRAS |
P01111 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-6798695
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-202733;
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392;
R-HSA-881907
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
|
MONDO:0008779 |
MONDO:0008779
Disease Name: arthrogryposis
All associated enzymes in DAR:
GBE1
EARS2
ASAH1
ATP2B3
ASAH1 |
Q13510 |
3.5.1.23
3.5.1.-
|
R-HSA-6798695
R-HSA-1660662
|
R-HSA-556833
R-HSA-168249
R-HSA-1430728
R-HSA-168256
R-HSA-428157
|
Metabolism
Immune System
|
R-HSA-1606602
(
R-HSA-1660662
)
R-HSA-1606602
Reaction Name: Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome)
See in Reactome
R-HSA-6798745
(
R-HSA-6798695
)
R-HSA-6798745
Reaction Name: Exocytosis of tertiary granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
|
MONDO:0008814 |
ARG1 |
P05089 |
3.5.3.1
|
R-HSA-70635
R-HSA-6798695
|
R-HSA-1430728
R-HSA-71291
R-HSA-71291
Reactome Name: Metabolism of amino acids and derivatives
See in Reactome
R-HSA-168249
R-HSA-168256
|
Metabolism
Immune System
|
R-HSA-6798749
(
R-HSA-6798695
)
R-HSA-6798749
Reaction Name: Exocytosis of specific granule lumen proteins
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-70569
(
R-HSA-70635
)
R-HSA-70569
Reaction Name: arginine + H2O => ornithine + urea [ARG1]
See in Reactome
|
MONDO:0008830 |
AGA |
P20933 |
3.5.1.26
|
R-HSA-6798695
|
R-HSA-168249
R-HSA-168256
|
Immune System
|
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
|
MONDO:0008913 |
PLD1 |
Q13393 |
3.1.4.4
|
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-1483166
R-HSA-8980692
R-HSA-9013408
R-HSA-6798695
R-HSA-1483148
R-HSA-9013149
R-HSA-9013148
|
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-9012999
R-HSA-168249
R-HSA-168256
R-HSA-194315
R-HSA-1483257
R-HSA-1483206
R-HSA-1483206
Reactome Name: Glycerophospholipid biosynthesis
See in Reactome
R-HSA-1430728
R-HSA-556833
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-162582
|
Immune System
Metabolism
Signal Transduction
|
R-HSA-1483142
(
R-HSA-1483148
)
R-HSA-1483142
Reaction Name: PC is transphosphatidylated to PG by PLD1-4/6
See in Reactome
R-HSA-1483182
(
R-HSA-1483166
)
R-HSA-1483182
Reaction Name: PC is hydrolyzed to PA and choline by PLD1/2
See in Reactome
R-HSA-2029471
(
R-HSA-2029485
)
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-6799350
(
R-HSA-6798695
)
R-HSA-6799350
Reaction Name: Exocytosis of specific granule membrane proteins
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9013157
(
R-HSA-9013148
)
R-HSA-9013157
Reaction Name: CDC42 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014449
(
R-HSA-9013408
)
R-HSA-9014449
Reaction Name: RHOG binds effectors at the plasma membrane
See in Reactome
|
MONDO:0008939 |
DDX3X |
O00571 |
3.6.4.13
|
R-HSA-6798695
|
R-HSA-168249
R-HSA-168256
|
Immune System
|
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
|
MONDO:0009021 |
DDX3X |
O00571 |
3.6.4.13
|
R-HSA-6798695
|
R-HSA-168249
R-HSA-168256
|
Immune System
|
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
|
MONDO:0009218 |
ASAH1 |
Q13510 |
3.5.1.23
3.5.1.-
|
R-HSA-6798695
R-HSA-1660662
|
R-HSA-556833
R-HSA-168249
R-HSA-1430728
R-HSA-168256
R-HSA-428157
|
Metabolism
Immune System
|
R-HSA-1606602
(
R-HSA-1660662
)
R-HSA-1606602
Reaction Name: Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome)
See in Reactome
R-HSA-6798745
(
R-HSA-6798695
)
R-HSA-6798745
Reaction Name: Exocytosis of tertiary granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
|
MONDO:0009254 |
MONDO:0009254
Disease Name: fucosidosis
OMIM id: OMIM:230000
Orphanet id: Orphanet:349
All associated enzymes in DAR:
FUCA1
. The disease is also associated to other non-enzyme proteins (not in DAR).
FUCA1 |
P04066 |
3.2.1.51
|
R-HSA-6798695
R-HSA-975578
R-HSA-975578
Reactome Name: Reactions specific to the complex N-glycan synthesis pathway
See in Reactome
|
R-HSA-168256
R-HSA-168249
R-HSA-392499
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-948021
R-HSA-948021
Reactome Name: Transport to the Golgi and subsequent modification
See in Reactome
R-HSA-975576
R-HSA-975576
Reactome Name: N-glycan antennae elongation in the medial/trans-Golgi
See in Reactome
|
Immune System
Metabolism of proteins
|
R-HSA-5693807
(
R-HSA-975578
)
R-HSA-5693807
Reaction Name: FUCA1 hydrolyses NGP:1,6-GlcNAc
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
|
MONDO:0009260 |
GLB1 |
P16278 |
3.2.1.23
|
R-HSA-2022857
R-HSA-2024096
R-HSA-1660662
R-HSA-6798695
R-HSA-4085001
|
R-HSA-446219
R-HSA-446219
Reactome Name: Synthesis of substrates in N-glycan biosythesis
See in Reactome
R-HSA-71387
R-HSA-1638074
R-HSA-1638074
Reactome Name: Keratan sulfate/keratin metabolism
See in Reactome
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-168249
R-HSA-168256
R-HSA-1638091
R-HSA-1638091
Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism
See in Reactome
R-HSA-392499
R-HSA-428157
R-HSA-1430728
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-556833
R-HSA-1630316
R-HSA-446193
R-HSA-446193
Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
See in Reactome
|
Immune System
Metabolism of proteins
Metabolism
|
R-HSA-1605624
(
R-HSA-1660662
)
R-HSA-1605624
Reaction Name: Beta-galactosidase hydrolyses GM1 to GM2
See in Reactome
R-HSA-1605724
(
R-HSA-1660662
)
R-HSA-1605724
Reaction Name: Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen)
See in Reactome
R-HSA-1606312
(
R-HSA-1660662
)
R-HSA-1606312
Reaction Name: Beta-galactosidase can also hydrolyse globosides to form cerebrosides
See in Reactome
R-HSA-1630306
(
R-HSA-2022857
)
R-HSA-1630306
Reaction Name: GLB1 hydrolyses a glycosaminoglycan
See in Reactome
R-HSA-2090079
(
R-HSA-2024096
)
R-HSA-2090079
Reaction Name: GLB1 hydrolyses linker chain(2)
See in Reactome
R-HSA-4084999
(
R-HSA-4085001
)
R-HSA-4084999
Reaction Name: NEU1 hydrolyses Neu5Ac from glycoconjugates
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-9638120
(
R-HSA-4085001
)
R-HSA-9638120
Reaction Name: NEU4 hydrolyses Neu5Ac from glycoconjugates
See in Reactome
|
MONDO:0009261 |
GLB1 |
P16278 |
3.2.1.23
|
R-HSA-2022857
R-HSA-2024096
R-HSA-1660662
R-HSA-6798695
R-HSA-4085001
|
R-HSA-446219
R-HSA-446219
Reactome Name: Synthesis of substrates in N-glycan biosythesis
See in Reactome
R-HSA-71387
R-HSA-1638074
R-HSA-1638074
Reactome Name: Keratan sulfate/keratin metabolism
See in Reactome
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-168249
R-HSA-168256
R-HSA-1638091
R-HSA-1638091
Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism
See in Reactome
R-HSA-392499
R-HSA-428157
R-HSA-1430728
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-556833
R-HSA-1630316
R-HSA-446193
R-HSA-446193
Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
See in Reactome
|
Immune System
Metabolism of proteins
Metabolism
|
R-HSA-1605624
(
R-HSA-1660662
)
R-HSA-1605624
Reaction Name: Beta-galactosidase hydrolyses GM1 to GM2
See in Reactome
R-HSA-1605724
(
R-HSA-1660662
)
R-HSA-1605724
Reaction Name: Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen)
See in Reactome
R-HSA-1606312
(
R-HSA-1660662
)
R-HSA-1606312
Reaction Name: Beta-galactosidase can also hydrolyse globosides to form cerebrosides
See in Reactome
R-HSA-1630306
(
R-HSA-2022857
)
R-HSA-1630306
Reaction Name: GLB1 hydrolyses a glycosaminoglycan
See in Reactome
R-HSA-2090079
(
R-HSA-2024096
)
R-HSA-2090079
Reaction Name: GLB1 hydrolyses linker chain(2)
See in Reactome
R-HSA-4084999
(
R-HSA-4085001
)
R-HSA-4084999
Reaction Name: NEU1 hydrolyses Neu5Ac from glycoconjugates
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-9638120
(
R-HSA-4085001
)
R-HSA-9638120
Reaction Name: NEU4 hydrolyses Neu5Ac from glycoconjugates
See in Reactome
|
MONDO:0009262 |
GLB1 |
P16278 |
3.2.1.23
|
R-HSA-2022857
R-HSA-2024096
R-HSA-1660662
R-HSA-6798695
R-HSA-4085001
|
R-HSA-446219
R-HSA-446219
Reactome Name: Synthesis of substrates in N-glycan biosythesis
See in Reactome
R-HSA-71387
R-HSA-1638074
R-HSA-1638074
Reactome Name: Keratan sulfate/keratin metabolism
See in Reactome
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-168249
R-HSA-168256
R-HSA-1638091
R-HSA-1638091
Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism
See in Reactome
R-HSA-392499
R-HSA-428157
R-HSA-1430728
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-556833
R-HSA-1630316
R-HSA-446193
R-HSA-446193
Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
See in Reactome
|
Immune System
Metabolism of proteins
Metabolism
|
R-HSA-1605624
(
R-HSA-1660662
)
R-HSA-1605624
Reaction Name: Beta-galactosidase hydrolyses GM1 to GM2
See in Reactome
R-HSA-1605724
(
R-HSA-1660662
)
R-HSA-1605724
Reaction Name: Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen)
See in Reactome
R-HSA-1606312
(
R-HSA-1660662
)
R-HSA-1606312
Reaction Name: Beta-galactosidase can also hydrolyse globosides to form cerebrosides
See in Reactome
R-HSA-1630306
(
R-HSA-2022857
)
R-HSA-1630306
Reaction Name: GLB1 hydrolyses a glycosaminoglycan
See in Reactome
R-HSA-2090079
(
R-HSA-2024096
)
R-HSA-2090079
Reaction Name: GLB1 hydrolyses linker chain(2)
See in Reactome
R-HSA-4084999
(
R-HSA-4085001
)
R-HSA-4084999
Reaction Name: NEU1 hydrolyses Neu5Ac from glycoconjugates
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-9638120
(
R-HSA-4085001
)
R-HSA-9638120
Reaction Name: NEU4 hydrolyses Neu5Ac from glycoconjugates
See in Reactome
|
MONDO:0009291 |
AGL |
P35573 |
3.2.1.33
2.4.1.25
|
R-HSA-6798695
R-HSA-70221
R-HSA-70221
Reactome Name: Glycogen breakdown (glycogenolysis)
See in Reactome
|
R-HSA-1430728
R-HSA-168249
R-HSA-168256
R-HSA-8982491
R-HSA-71387
|
Metabolism
Immune System
|
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-71552
(
R-HSA-70221
)
R-HSA-71552
Reaction Name: limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin
See in Reactome
R-HSA-71593
(
R-HSA-70221
)
R-HSA-71593
Reaction Name: ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose
See in Reactome
|
MONDO:0009294 |
PYGL |
P06737 |
2.4.1.1
|
R-HSA-6798695
R-HSA-70221
R-HSA-70221
Reactome Name: Glycogen breakdown (glycogenolysis)
See in Reactome
|
R-HSA-1430728
R-HSA-168249
R-HSA-168256
R-HSA-8982491
R-HSA-71387
|
Metabolism
Immune System
|
R-HSA-453339
(
R-HSA-70221
)
R-HSA-453339
Reaction Name: poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL]
See in Reactome
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-71588
(
R-HSA-70221
)
R-HSA-71588
Reaction Name: glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP
See in Reactome
R-HSA-71590
(
R-HSA-70221
)
R-HSA-71590
Reaction Name: glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL]
See in Reactome
|
MONDO:0009296 |
GAA |
P10253 |
3.2.1.20
|
R-HSA-6798695
R-HSA-70221
R-HSA-70221
Reactome Name: Glycogen breakdown (glycogenolysis)
See in Reactome
|
R-HSA-1430728
R-HSA-168249
R-HSA-168256
R-HSA-8982491
R-HSA-71387
|
Metabolism
Immune System
|
R-HSA-6798739
(
R-HSA-6798695
)
R-HSA-6798739
Reaction Name: Exocytosis of azurophil granule membrane proteins
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-9036727
(
R-HSA-70221
)
R-HSA-9036727
Reaction Name: GAA hydrolyzes lysosomal glycogen
See in Reactome
|
MONDO:0009327 |
MAPK1 |
P28482 |
2.7.11.24
|
R-HSA-2559585
R-HSA-445144
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-111995
R-HSA-2559580
R-HSA-2559580
Reactome Name: Oxidative Stress Induced Senescence
See in Reactome
R-HSA-198753
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-8940973
R-HSA-8940973
Reactome Name: RUNX2 regulates osteoblast differentiation
See in Reactome
R-HSA-170968
R-HSA-437239
R-HSA-444257
R-HSA-6798695
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-1181150
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-982772
R-HSA-982772
Reactome Name: Growth hormone receptor signaling
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-2559582
R-HSA-2559582
Reactome Name: Senescence-Associated Secretory Phenotype (SASP)
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-5673001
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-2173796
R-HSA-2173796
Reactome Name: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
See in Reactome
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
R-HSA-1502540
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-450341
R-HSA-450341
Reactome Name: Activation of the AP-1 family of transcription factors
See in Reactome
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-74749
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-8939211
R-HSA-5674135
R-HSA-202670
R-HSA-879415
R-HSA-879415
Reactome Name: Advanced glycosylation endproduct receptor signaling
See in Reactome
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-162658
R-HSA-162658
Reactome Name: Golgi Cisternae Pericentriolar Stack Reorganization
See in Reactome
R-HSA-456926
R-HSA-456926
Reactome Name: Thrombin signalling through proteinase activated receptors (PARs)
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-112411
R-HSA-9627069
R-HSA-9627069
Reactome Name: Regulation of the apoptosome activity
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-111996
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-1640170
R-HSA-1266738
R-HSA-73857
R-HSA-212436
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-2262752
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-112316
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-373760
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-450294
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-416476
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-111471
R-HSA-111471
Reactome Name: Apoptotic factor-mediated response
See in Reactome
R-HSA-168256
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-450282
R-HSA-450282
Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases
See in Reactome
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-111461
R-HSA-111461
Reactome Name: Cytochrome c-mediated apoptotic response
See in Reactome
R-HSA-69278
R-HSA-198725
R-HSA-198725
Reactome Name: Nuclear Events (kinase and transcription factor activation)
See in Reactome
R-HSA-166166
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-168249
R-HSA-68886
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-187037
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-112043
R-HSA-112040
R-HSA-5654738
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-422475
R-HSA-68875
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-2559583
R-HSA-8941326
R-HSA-8941326
Reactome Name: RUNX2 regulates bone development
See in Reactome
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-5357801
R-HSA-74752
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-74160
R-HSA-168898
R-HSA-2173793
R-HSA-2173793
Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-8953897
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-111885
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-187687
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
R-HSA-449147
R-HSA-418594
R-HSA-194315
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-5684996
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-5654743
R-HSA-5654741
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-190236
R-HSA-388396
R-HSA-5654736
R-HSA-195258
R-HSA-1257604
R-HSA-372790
R-HSA-6807070
R-HSA-448424
R-HSA-109581
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-111458
R-HSA-109582
R-HSA-162582
|
Cell Cycle
Developmental Biology
Neuronal System
Immune System
Programmed Cell Death
Gene expression (Transcription)
Cellular responses to stimuli
Hemostasis
Signal Transduction
|
R-HSA-109822
(
R-HSA-74749
)
R-HSA-109822
Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1
See in Reactome
R-HSA-109823
(
R-HSA-74749
)
R-HSA-109823
Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2
See in Reactome
R-HSA-109858
(
R-HSA-112409;
R-HSA-112411
)
R-HSA-109862
(
R-HSA-112409;
R-HSA-112411;
R-HSA-445144
)
R-HSA-109864
(
R-HSA-112409;
R-HSA-112411
)
R-HSA-109864
Reaction Name: Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2
See in Reactome
R-HSA-111898
(
R-HSA-111995
)
R-HSA-111898
Reaction Name: Phosphorylation of cPLA2 by ERK-2
See in Reactome
R-HSA-1168459
(
R-HSA-982772
)
R-HSA-1295634
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-168053
(
R-HSA-166058;
R-HSA-168188;
R-HSA-450341
)
R-HSA-168053
Reaction Name: Phosphorylated MAPKs phosphorylate ATF-2
See in Reactome
R-HSA-173488
(
R-HSA-1181150;
R-HSA-1502540;
R-HSA-2173796
)
R-HSA-173488
Reaction Name: The SMAD2/3:SMAD4 complex transfers to the nucleus
See in Reactome
R-HSA-198731
(
R-HSA-166058;
R-HSA-168188;
R-HSA-198753;
R-HSA-8939211;
R-HSA-9634638
)
R-HSA-198746
(
R-HSA-166058;
R-HSA-168188;
R-HSA-198753;
R-HSA-2559582;
R-HSA-881907
)
R-HSA-198756
(
R-HSA-166058;
R-HSA-168188;
R-HSA-198753;
R-HSA-375165
)
R-HSA-199959
(
R-HSA-166058;
R-HSA-168188;
R-HSA-198753;
R-HSA-202670
)
R-HSA-199959
Reaction Name: ERKs are inactivated by protein phosphatase 2A
See in Reactome
R-HSA-2029469
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029469
Reaction Name: p-ERK phosphorylates WAVEs and ABI
See in Reactome
R-HSA-203797
(
R-HSA-166058;
R-HSA-168188;
R-HSA-198753;
R-HSA-202670
)
R-HSA-203797
Reaction Name: ERKs are inactivated by dual-specific phosphatases (DUSPs)
See in Reactome
R-HSA-2422927
(
R-HSA-162658
)
R-HSA-2422927
Reaction Name: MAPK3-3 or MAPK1 phosphorylate GORASP2
See in Reactome
R-HSA-3132737
(
R-HSA-2559585
)
R-HSA-3132737
Reaction Name: MAPKs phosphorylate ETS1 and ETS2
See in Reactome
R-HSA-3209160
(
R-HSA-2559585
)
R-HSA-3209160
Reaction Name: Activated ERKs phosphorylate ERF
See in Reactome
R-HSA-3209177
(
R-HSA-2559585
)
R-HSA-3223236
(
R-HSA-2559580
)
R-HSA-3223236
Reaction Name: RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS)
See in Reactome
R-HSA-3371531
(
R-HSA-3371453
)
R-HSA-3371531
Reaction Name: Constitutive phosphorylation by pERK1/2
See in Reactome
R-HSA-3857329
(
R-HSA-2559582
)
R-HSA-3857329
Reaction Name: MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB
See in Reactome
R-HSA-418158
(
R-HSA-456926
)
R-HSA-418158
Reaction Name: SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1)
See in Reactome
R-HSA-418163
(
R-HSA-456926
)
R-HSA-418163
Reaction Name: Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)
See in Reactome
R-HSA-418170
(
R-HSA-456926
)
R-HSA-418176
(
R-HSA-456926
)
R-HSA-418200
(
R-HSA-456926
)
R-HSA-418200
Reaction Name: SRC-1 bound to ARRB2 is not activated
See in Reactome
R-HSA-445079
(
R-HSA-437239
)
R-HSA-450325
(
R-HSA-166058;
R-HSA-168188;
R-HSA-2559580;
R-HSA-2871796;
R-HSA-450341
)
R-HSA-450325
Reaction Name: c-FOS activation by phospho ERK1/2
See in Reactome
R-HSA-5654560
(
R-HSA-5654726
)
R-HSA-5654560
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2.
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654565
(
R-HSA-5654732
)
R-HSA-5654565
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2.
See in Reactome
R-HSA-5654566
(
R-HSA-5654733
)
R-HSA-5654566
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2.
See in Reactome
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674366
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674366
Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs
See in Reactome
R-HSA-5674373
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674373
Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane
See in Reactome
R-HSA-5674385
(
R-HSA-112409;
R-HSA-170968;
R-HSA-5673001
)
R-HSA-5674387
(
R-HSA-112409;
R-HSA-5673001
)
R-HSA-5674387
Reaction Name: Phosphorylated MAPKs translocate into the nucleus
See in Reactome
R-HSA-5674496
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5674496
Reaction Name: Activated MAPKs phosphorylate MAP2K1
See in Reactome
R-HSA-5675194
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675194
Reaction Name: Activated MAPK phosphorylates RAF1
See in Reactome
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675206
(
R-HSA-112409;
R-HSA-5673001
)
R-HSA-5675206
Reaction Name: PEA15 binds MAPK monomers and dimers
See in Reactome
R-HSA-5675373
(
R-HSA-112409;
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675373
Reaction Name: Nuclear DUSPs dephosphorylate MAPKs
See in Reactome
R-HSA-5675376
(
R-HSA-112409;
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675376
Reaction Name: Cytosolic DUSPs dephosphorylate MAPKs
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-6811454
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-6811472
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-6811472
Reaction Name: IER3 recruits MAPKs to PP2A-B56-beta,gamma
See in Reactome
R-HSA-879362
(
R-HSA-879415
)
R-HSA-8944047
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944047
Reaction Name: JUN binds the PTEN gene promoter
See in Reactome
R-HSA-9009208
(
R-HSA-8940973
)
R-HSA-9009208
Reaction Name: Activated ERKs phosphorylate RUNX2
See in Reactome
R-HSA-9032751
(
R-HSA-8939211
)
R-HSA-9032751
Reaction Name: Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610166
(
R-HSA-170968
)
R-HSA-9610166
Reaction Name: p-T,Y MAPK dimers translocate to nucleus
See in Reactome
R-HSA-9619843
(
R-HSA-444257
)
R-HSA-9626832
(
R-HSA-5668599
)
R-HSA-9626832
Reaction Name: MAPK1 or MAPK3 phosphorylates NCF1 at Ser345
See in Reactome
R-HSA-9627089
(
R-HSA-9627069
)
R-HSA-9627089
Reaction Name: CASP9 is phosphorylated at T125
See in Reactome
R-HSA-9632873
(
R-HSA-8939211;
R-HSA-9634638
)
R-HSA-9632873
Reaction Name: p-S10 CDKN1B translocates to the cytosol
See in Reactome
R-HSA-9632910
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9635739
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-9635739
Reaction Name: PTPN7 dephosphorylates p-T,Y-MAPKs
See in Reactome
R-HSA-9635743
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
|
MONDO:0009369 |
GUSB |
P08236 |
3.2.1.31
|
R-HSA-6798695
R-HSA-2024096
R-HSA-2160916
R-HSA-2160916
Reactome Name: Hyaluronan uptake and degradation
See in Reactome
|
R-HSA-71387
R-HSA-168256
R-HSA-168249
R-HSA-1638091
R-HSA-1638091
Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism
See in Reactome
R-HSA-2142845
R-HSA-1430728
R-HSA-1630316
|
Immune System
Metabolism
|
R-HSA-1678854
(
R-HSA-2024096
)
R-HSA-1678854
Reaction Name: GUSB tetramer hydrolyses CS/HS precursor
See in Reactome
R-HSA-2162226
(
R-HSA-2160916
)
R-HSA-2162226
Reaction Name: GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc
See in Reactome
R-HSA-2162227
(
R-HSA-2160916
)
R-HSA-2162227
Reaction Name: GUSB tetramer hydrolyses (HA)2
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
|
MONDO:0009490 |
CTSC |
P53634 |
3.4.14.1
|
R-HSA-6798695
R-HSA-5694530
R-HSA-204005
R-HSA-204005
Reactome Name: COPII-mediated vesicle transport
See in Reactome
R-HSA-2132295
R-HSA-2132295
Reactome Name: MHC class II antigen presentation
See in Reactome
|
R-HSA-168249
R-HSA-168256
R-HSA-392499
R-HSA-199991
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-199977
R-HSA-199977
Reactome Name: ER to Golgi Anterograde Transport
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-948021
R-HSA-948021
Reactome Name: Transport to the Golgi and subsequent modification
See in Reactome
R-HSA-1280218
R-HSA-5653656
|
Immune System
Metabolism of proteins
Vesicle-mediated transport
|
R-HSA-203973
(
R-HSA-204005
)
R-HSA-204008
(
R-HSA-204005
)
R-HSA-204008
Reaction Name: SEC31:SEC13 and v-SNARE recruitment
See in Reactome
R-HSA-2130349
(
R-HSA-2132295
)
R-HSA-2130504
(
R-HSA-2132295
)
R-HSA-2130706
(
R-HSA-2132295
)
R-HSA-2130706
Reaction Name: MHC class II antigen processing
See in Reactome
R-HSA-5694409
(
R-HSA-204005
)
R-HSA-5694417
(
R-HSA-204005
)
R-HSA-5694417
Reaction Name: SEC16 complex binds SAR1B:GTP:SEC23:SEC24
See in Reactome
R-HSA-5694418
(
R-HSA-204005
)
R-HSA-5694418
Reaction Name: RAB1:GTP binds USO1 and GORASP1:GOLGA2
See in Reactome
R-HSA-5694428
(
R-HSA-5694530
)
R-HSA-5694428
Reaction Name: LMAN family proteins bind glycosylated cargo
See in Reactome
R-HSA-5694439
(
R-HSA-204005
)
R-HSA-5694439
Reaction Name: COPII coat binds TRAPPCII and RAB1:GDP
See in Reactome
R-HSA-5694441
(
R-HSA-204005
)
R-HSA-5694446
(
R-HSA-204005
)
R-HSA-5694446
Reaction Name: BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle
See in Reactome
R-HSA-5694522
(
R-HSA-204005;
R-HSA-5694530
)
R-HSA-5694522
Reaction Name: Inner coat assembly and cargo binding
See in Reactome
R-HSA-5694527
(
R-HSA-204005
)
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
|
MONDO:0009491 |
CTSC |
P53634 |
3.4.14.1
|
R-HSA-6798695
R-HSA-5694530
R-HSA-204005
R-HSA-204005
Reactome Name: COPII-mediated vesicle transport
See in Reactome
R-HSA-2132295
R-HSA-2132295
Reactome Name: MHC class II antigen presentation
See in Reactome
|
R-HSA-168249
R-HSA-168256
R-HSA-392499
R-HSA-199991
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-199977
R-HSA-199977
Reactome Name: ER to Golgi Anterograde Transport
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-948021
R-HSA-948021
Reactome Name: Transport to the Golgi and subsequent modification
See in Reactome
R-HSA-1280218
R-HSA-5653656
|
Immune System
Metabolism of proteins
Vesicle-mediated transport
|
R-HSA-203973
(
R-HSA-204005
)
R-HSA-204008
(
R-HSA-204005
)
R-HSA-204008
Reaction Name: SEC31:SEC13 and v-SNARE recruitment
See in Reactome
R-HSA-2130349
(
R-HSA-2132295
)
R-HSA-2130504
(
R-HSA-2132295
)
R-HSA-2130706
(
R-HSA-2132295
)
R-HSA-2130706
Reaction Name: MHC class II antigen processing
See in Reactome
R-HSA-5694409
(
R-HSA-204005
)
R-HSA-5694417
(
R-HSA-204005
)
R-HSA-5694417
Reaction Name: SEC16 complex binds SAR1B:GTP:SEC23:SEC24
See in Reactome
R-HSA-5694418
(
R-HSA-204005
)
R-HSA-5694418
Reaction Name: RAB1:GTP binds USO1 and GORASP1:GOLGA2
See in Reactome
R-HSA-5694428
(
R-HSA-5694530
)
R-HSA-5694428
Reaction Name: LMAN family proteins bind glycosylated cargo
See in Reactome
R-HSA-5694439
(
R-HSA-204005
)
R-HSA-5694439
Reaction Name: COPII coat binds TRAPPCII and RAB1:GDP
See in Reactome
R-HSA-5694441
(
R-HSA-204005
)
R-HSA-5694446
(
R-HSA-204005
)
R-HSA-5694446
Reaction Name: BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle
See in Reactome
R-HSA-5694522
(
R-HSA-204005;
R-HSA-5694530
)
R-HSA-5694522
Reaction Name: Inner coat assembly and cargo binding
See in Reactome
R-HSA-5694527
(
R-HSA-204005
)
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
|
MONDO:0009562 |
MANBA |
O00462 |
3.2.1.25
|
R-HSA-6798695
R-HSA-8853383
R-HSA-8853383
Reactome Name: Lysosomal oligosaccharide catabolism
See in Reactome
|
R-HSA-168249
R-HSA-1430728
R-HSA-168256
R-HSA-71387
|
Metabolism
Immune System
|
R-HSA-6798739
(
R-HSA-6798695
)
R-HSA-6798739
Reaction Name: Exocytosis of azurophil granule membrane proteins
See in Reactome
R-HSA-8853710
(
R-HSA-8853383
)
|
MONDO:0009578 |
NRAS |
P01111 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-6798695
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-202733;
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392;
R-HSA-881907
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
|
MONDO:0009591 |
ARSB |
P15848 |
3.1.6.12
|
R-HSA-6798695
R-HSA-2024101
R-HSA-1660662
R-HSA-1663150
R-HSA-1663150
Reactome Name: The activation of arylsulfatases
See in Reactome
|
R-HSA-71387
R-HSA-1793185
R-HSA-1793185
Reactome Name: Chondroitin sulfate/dermatan sulfate metabolism
See in Reactome
R-HSA-168256
R-HSA-163841
R-HSA-163841
Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-428157
R-HSA-1430728
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-556833
R-HSA-1630316
|
Immune System
Metabolism of proteins
Metabolism
|
R-HSA-1606789
(
R-HSA-2024101
)
R-HSA-1614362
(
R-HSA-1660662;
R-HSA-1663150
)
R-HSA-1614362
Reaction Name: SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases
See in Reactome
R-HSA-1793207
(
R-HSA-2024101
)
R-HSA-1793207
Reaction Name: ARSB hydrolyses C4S/C6S chains
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
|
MONDO:0009606 |
CYB5R3 |
P00387 |
1.6.2.2
|
R-HSA-6798695
R-HSA-211945
R-HSA-211945
Reactome Name: Phase I - Functionalization of compounds
See in Reactome
R-HSA-196836
R-HSA-196836
Reactome Name: Vitamin C (ascorbate) metabolism
See in Reactome
|
R-HSA-168256
R-HSA-211859
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-168249
R-HSA-1430728
R-HSA-196849
R-HSA-196849
Reactome Name: Metabolism of water-soluble vitamins and cofactors
See in Reactome
|
Immune System
Metabolism
|
R-HSA-198824
(
R-HSA-196836
)
R-HSA-198824
Reaction Name: CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-8936442
(
R-HSA-211945
)
R-HSA-8936442
Reaction Name: MARC1,MARC2 reduce N-hydroxylated compounds
See in Reactome
|
MONDO:0009629 |
CANT1 |
Q8WVQ1 |
3.6.1.6
|
R-HSA-6798695
|
R-HSA-168249
R-HSA-168256
|
Immune System
|
R-HSA-6798745
(
R-HSA-6798695
)
R-HSA-6798745
Reaction Name: Exocytosis of tertiary granule lumen proteins
See in Reactome
R-HSA-6798749
(
R-HSA-6798695
)
R-HSA-6798749
Reaction Name: Exocytosis of specific granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
|
MONDO:0009657 |
HGSNAT |
Q68CP4 |
2.3.1.78
|
R-HSA-6798695
R-HSA-2024096
|
R-HSA-71387
R-HSA-168256
R-HSA-168249
R-HSA-1638091
R-HSA-1638091
Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism
See in Reactome
R-HSA-1430728
R-HSA-1630316
|
Immune System
Metabolism
|
R-HSA-1678660
(
R-HSA-2024096
)
R-HSA-1678660
Reaction Name: HGSNAT oligomer acetylates Heparan sulfate chain(3)
See in Reactome
R-HSA-2090085
(
R-HSA-2024096
)
R-HSA-2090085
Reaction Name: HGSNAT oligomer acetylates Heparan chain(1)
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-6799350
(
R-HSA-6798695
)
R-HSA-6799350
Reaction Name: Exocytosis of specific granule membrane proteins
See in Reactome
|
MONDO:0009658 |
GNS |
P15586 |
3.1.6.14
|
R-HSA-2022857
R-HSA-432720
R-HSA-6798695
|
R-HSA-71387
R-HSA-1638074
R-HSA-1638074
Reactome Name: Keratan sulfate/keratin metabolism
See in Reactome
R-HSA-168249
R-HSA-168256
R-HSA-199991
R-HSA-199992
R-HSA-199992
Reactome Name: trans-Golgi Network Vesicle Budding
See in Reactome
R-HSA-1430728
R-HSA-1630316
R-HSA-5653656
|
Immune System
Metabolism
Vesicle-mediated transport
|
R-HSA-1638032
(
R-HSA-2022857
)
R-HSA-1638032
Reaction Name: N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate
See in Reactome
R-HSA-432688
(
R-HSA-432720
)
R-HSA-432688
Reaction Name: trans-Golgi Network Derived Lysosomal Vesicle Uncoating
See in Reactome
R-HSA-432706
(
R-HSA-432720
)
R-HSA-432706
Reaction Name: trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly
See in Reactome
R-HSA-432707
(
R-HSA-432720
)
R-HSA-432707
Reaction Name: trans-Golgi Network Lysosomal Vesicle Scission
See in Reactome
R-HSA-432712
(
R-HSA-432720
)
R-HSA-432712
Reaction Name: Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
|
MONDO:0009659 |
GALNS |
P34059 |
3.1.6.4
|
R-HSA-2022857
R-HSA-6798695
|
R-HSA-71387
R-HSA-1638074
R-HSA-1638074
Reactome Name: Keratan sulfate/keratin metabolism
See in Reactome
R-HSA-168256
R-HSA-168249
R-HSA-1430728
R-HSA-1630316
|
Immune System
Metabolism
|
R-HSA-1630304
(
R-HSA-2022857
)
R-HSA-1630304
Reaction Name: GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
|
MONDO:0009660 |
GLB1 |
P16278 |
3.2.1.23
|
R-HSA-2022857
R-HSA-2024096
R-HSA-1660662
R-HSA-6798695
R-HSA-4085001
|
R-HSA-446219
R-HSA-446219
Reactome Name: Synthesis of substrates in N-glycan biosythesis
See in Reactome
R-HSA-71387
R-HSA-1638074
R-HSA-1638074
Reactome Name: Keratan sulfate/keratin metabolism
See in Reactome
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-168249
R-HSA-168256
R-HSA-1638091
R-HSA-1638091
Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism
See in Reactome
R-HSA-392499
R-HSA-428157
R-HSA-1430728
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-556833
R-HSA-1630316
R-HSA-446193
R-HSA-446193
Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
See in Reactome
|
Immune System
Metabolism of proteins
Metabolism
|
R-HSA-1605624
(
R-HSA-1660662
)
R-HSA-1605624
Reaction Name: Beta-galactosidase hydrolyses GM1 to GM2
See in Reactome
R-HSA-1605724
(
R-HSA-1660662
)
R-HSA-1605724
Reaction Name: Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen)
See in Reactome
R-HSA-1606312
(
R-HSA-1660662
)
R-HSA-1606312
Reaction Name: Beta-galactosidase can also hydrolyse globosides to form cerebrosides
See in Reactome
R-HSA-1630306
(
R-HSA-2022857
)
R-HSA-1630306
Reaction Name: GLB1 hydrolyses a glycosaminoglycan
See in Reactome
R-HSA-2090079
(
R-HSA-2024096
)
R-HSA-2090079
Reaction Name: GLB1 hydrolyses linker chain(2)
See in Reactome
R-HSA-4084999
(
R-HSA-4085001
)
R-HSA-4084999
Reaction Name: NEU1 hydrolyses Neu5Ac from glycoconjugates
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-9638120
(
R-HSA-4085001
)
R-HSA-9638120
Reaction Name: NEU4 hydrolyses Neu5Ac from glycoconjugates
See in Reactome
|
MONDO:0009661 |
GUSB |
P08236 |
3.2.1.31
|
R-HSA-6798695
R-HSA-2024096
R-HSA-2160916
R-HSA-2160916
Reactome Name: Hyaluronan uptake and degradation
See in Reactome
|
R-HSA-71387
R-HSA-168256
R-HSA-168249
R-HSA-1638091
R-HSA-1638091
Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism
See in Reactome
R-HSA-2142845
R-HSA-1430728
R-HSA-1630316
|
Immune System
Metabolism
|
R-HSA-1678854
(
R-HSA-2024096
)
R-HSA-1678854
Reaction Name: GUSB tetramer hydrolyses CS/HS precursor
See in Reactome
R-HSA-2162226
(
R-HSA-2160916
)
R-HSA-2162226
Reaction Name: GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc
See in Reactome
R-HSA-2162227
(
R-HSA-2160916
)
R-HSA-2162227
Reaction Name: GUSB tetramer hydrolyses (HA)2
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
|
MONDO:0009662 |
GUSB |
P08236 |
3.2.1.31
|
R-HSA-6798695
R-HSA-2024096
R-HSA-2160916
R-HSA-2160916
Reactome Name: Hyaluronan uptake and degradation
See in Reactome
|
R-HSA-71387
R-HSA-168256
R-HSA-168249
R-HSA-1638091
R-HSA-1638091
Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism
See in Reactome
R-HSA-2142845
R-HSA-1430728
R-HSA-1630316
|
Immune System
Metabolism
|
R-HSA-1678854
(
R-HSA-2024096
)
R-HSA-1678854
Reaction Name: GUSB tetramer hydrolyses CS/HS precursor
See in Reactome
R-HSA-2162226
(
R-HSA-2160916
)
R-HSA-2162226
Reaction Name: GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc
See in Reactome
R-HSA-2162227
(
R-HSA-2160916
)
R-HSA-2162227
Reaction Name: GUSB tetramer hydrolyses (HA)2
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
|
MONDO:0009694 |
MPO |
P05164 |
1.11.2.2
|
R-HSA-6798695
R-HSA-8941413
R-HSA-8941413
Reactome Name: Events associated with phagocytolytic activity of PMN cells
See in Reactome
|
R-HSA-1222556
R-HSA-1222556
Reactome Name: ROS and RNS production in phagocytes
See in Reactome
R-HSA-168256
R-HSA-168249
|
Immune System
|
R-HSA-6789031
(
R-HSA-8941413
)
R-HSA-6789031
Reaction Name: Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)
See in Reactome
R-HSA-6789126
(
R-HSA-8941413
)
R-HSA-6789126
Reaction Name: Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)
See in Reactome
R-HSA-6789136
(
R-HSA-8941413
)
R-HSA-6789136
Reaction Name: Myeloperoxidase (MPO) binds to the bacterial cell surface
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-8933635
(
R-HSA-8941413
)
R-HSA-8933635
Reaction Name: Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide
See in Reactome
|
MONDO:0009737 |
CTSA |
P10619 |
3.4.16.5
|
R-HSA-4085001
R-HSA-1660662
R-HSA-6798695
R-HSA-2132295
R-HSA-2132295
Reactome Name: MHC class II antigen presentation
See in Reactome
|
R-HSA-446219
R-HSA-446219
Reactome Name: Synthesis of substrates in N-glycan biosythesis
See in Reactome
R-HSA-446193
R-HSA-446193
Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
See in Reactome
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-168256
R-HSA-168249
R-HSA-392499
R-HSA-428157
R-HSA-1430728
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
|
Immune System
Metabolism of proteins
Metabolism
|
R-HSA-1605724
(
R-HSA-1660662
)
R-HSA-1605724
Reaction Name: Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen)
See in Reactome
R-HSA-2130349
(
R-HSA-2132295
)
R-HSA-2130504
(
R-HSA-2132295
)
R-HSA-2130706
(
R-HSA-2132295
)
R-HSA-2130706
Reaction Name: MHC class II antigen processing
See in Reactome
R-HSA-4084999
(
R-HSA-4085001
)
R-HSA-4084999
Reaction Name: NEU1 hydrolyses Neu5Ac from glycoconjugates
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-9638120
(
R-HSA-4085001
)
R-HSA-9638120
Reaction Name: NEU4 hydrolyses Neu5Ac from glycoconjugates
See in Reactome
|
MONDO:0009885 |
ANO6 |
Q4KMQ2 |
-
|
R-HSA-6798695
R-HSA-2672351
|
R-HSA-168249
R-HSA-983712
R-HSA-168256
R-HSA-382551
|
Immune System
Transport of small molecules
|
R-HSA-2684901
(
R-HSA-2672351
)
R-HSA-2684901
Reaction Name: ANOs transport cytosolic Cl- to extracellular region
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-6799350
(
R-HSA-6798695
)
R-HSA-6799350
Reaction Name: Exocytosis of specific granule membrane proteins
See in Reactome
|
MONDO:0010088 |
ARSA |
P15289 |
3.1.6.8
|
R-HSA-6798695
R-HSA-1660662
R-HSA-1663150
R-HSA-1663150
Reactome Name: The activation of arylsulfatases
See in Reactome
|
R-HSA-168256
R-HSA-163841
R-HSA-163841
Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-428157
R-HSA-1430728
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
|
Immune System
Metabolism of proteins
Metabolism
|
R-HSA-1606807
(
R-HSA-1660662
)
R-HSA-1606807
Reaction Name: Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside
See in Reactome
R-HSA-1614362
(
R-HSA-1660662;
R-HSA-1663150
)
R-HSA-1614362
Reaction Name: SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases
See in Reactome
R-HSA-2248891
(
R-HSA-1660662
)
R-HSA-2248891
Reaction Name: Active ARSA translocates to the lysosome
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
|
MONDO:0010088 |
ARSB |
P15848 |
3.1.6.12
|
R-HSA-6798695
R-HSA-2024101
R-HSA-1660662
R-HSA-1663150
R-HSA-1663150
Reactome Name: The activation of arylsulfatases
See in Reactome
|
R-HSA-71387
R-HSA-1793185
R-HSA-1793185
Reactome Name: Chondroitin sulfate/dermatan sulfate metabolism
See in Reactome
R-HSA-168256
R-HSA-163841
R-HSA-163841
Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-428157
R-HSA-1430728
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-556833
R-HSA-1630316
|
Immune System
Metabolism of proteins
Metabolism
|
R-HSA-1606789
(
R-HSA-2024101
)
R-HSA-1614362
(
R-HSA-1660662;
R-HSA-1663150
)
R-HSA-1614362
Reaction Name: SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases
See in Reactome
R-HSA-1793207
(
R-HSA-2024101
)
R-HSA-1793207
Reaction Name: ARSB hydrolyses C4S/C6S chains
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
|
MONDO:0010099 |
GM2A |
P17900 |
-
|
R-HSA-6798695
R-HSA-1660662
|
R-HSA-556833
R-HSA-168249
R-HSA-1430728
R-HSA-168256
R-HSA-428157
|
Metabolism
Immune System
|
R-HSA-1605595
(
R-HSA-1660662
)
R-HSA-1605595
Reaction Name: Hexosaminidase A cleaves GalNAc from GM2 to form GM3
See in Reactome
R-HSA-1605717
(
R-HSA-1660662
)
R-HSA-1605717
Reaction Name: Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
|
MONDO:0010108 |
STK10 |
O94804 |
2.7.11.1
|
R-HSA-6798695
R-HSA-9013106
R-HSA-9013026
R-HSA-8980692
|
R-HSA-9012999
R-HSA-168256
R-HSA-168249
R-HSA-194315
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-162582
|
Immune System
Signal Transduction
|
R-HSA-6799350
(
R-HSA-6798695
)
R-HSA-6799350
Reaction Name: Exocytosis of specific granule membrane proteins
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013024
(
R-HSA-9013026
)
R-HSA-9013024
Reaction Name: RHOB binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0010150 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0010150 |
RAC1 |
P63000 |
3.6.5.2
|
R-HSA-376172
R-HSA-445144
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-9619229
R-HSA-9619229
Reactome Name: Activation of RAC1 downstream of NMDARs
See in Reactome
R-HSA-428540
R-HSA-428543
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-399954
R-HSA-399954
Reactome Name: Sema3A PAK dependent Axon repulsion
See in Reactome
R-HSA-9032845
R-HSA-9032845
Reactome Name: Activated NTRK2 signals through CDK5
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-6798695
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-193648
R-HSA-193648
Reactome Name: NRAGE signals death through JNK
See in Reactome
R-HSA-5625900
R-HSA-5625740
R-HSA-9032759
R-HSA-1257604
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-389359
R-HSA-5627123
R-HSA-399955
R-HSA-399955
Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
See in Reactome
R-HSA-5626467
R-HSA-4420097
R-HSA-5663220
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5687128
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1433557
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-2424491
R-HSA-9013149
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-8875555
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-3928664
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-8848021
R-HSA-1280218
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9675108
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-112316
R-HSA-8875878
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-373760
R-HSA-9032500
R-HSA-9032500
Reactome Name: Activated NTRK2 signals through FYN
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-168249
R-HSA-195258
R-HSA-199991
R-HSA-73887
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-2682334
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-5653656
R-HSA-6806834
R-HSA-195721
R-HSA-2172127
R-HSA-204998
R-HSA-204998
Reactome Name: Cell death signalling via NRAGE, NRIF and NADE
See in Reactome
R-HSA-373755
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Developmental Biology
Neuronal System
Vesicle-mediated transport
Hemostasis
Signal Transduction
|
R-HSA-1011598
(
R-HSA-983231
)
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1433415
(
R-HSA-1433557
)
R-HSA-2029451
(
R-HSA-2029482
)
R-HSA-2029454
(
R-HSA-2029482
)
R-HSA-2029456
(
R-HSA-2029482;
R-HSA-5627123
)
R-HSA-2029465
(
R-HSA-2029482;
R-HSA-4420097;
R-HSA-5663213
)
R-HSA-2029465
Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)
See in Reactome
R-HSA-2029466
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029466
Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin
See in Reactome
R-HSA-2029467
(
R-HSA-2029482
)
R-HSA-2029467
Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO
See in Reactome
R-HSA-2029469
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029469
Reaction Name: p-ERK phosphorylates WAVEs and ABI
See in Reactome
R-HSA-205039
(
R-HSA-193648
)
R-HSA-205039
Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
See in Reactome
R-HSA-205136
(
R-HSA-193648
)
R-HSA-205136
Reaction Name: GTP-bound RAC contributes to JNK activation
See in Reactome
R-HSA-2130194
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2197690
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2316352
(
R-HSA-1445148
)
R-HSA-2316352
Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424476
(
R-HSA-2424491
)
R-HSA-2730840
(
R-HSA-2871796
)
R-HSA-2730856
(
R-HSA-2871796
)
R-HSA-2730889
(
R-HSA-2871796
)
R-HSA-2730889
Reaction Name: Recruitment of PAK to the membrane by binding active RAC1
See in Reactome
R-HSA-376123
(
R-HSA-376172
)
R-HSA-376123
Reaction Name: DSCAM associates with Rac1-GTP:pPAK1
See in Reactome
R-HSA-3858475
(
R-HSA-4086400
)
R-HSA-389348
(
R-HSA-389359
)
R-HSA-389788
(
R-HSA-389359;
R-HSA-5687128
)
R-HSA-389788
Reaction Name: Activation of PAKs by RAC1 and CDC42
See in Reactome
R-HSA-3928612
(
R-HSA-3928662
)
R-HSA-3928612
Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928619
(
R-HSA-3928662
)
R-HSA-3928620
(
R-HSA-3928662
)
R-HSA-3928625
(
R-HSA-3928664
)
R-HSA-3928628
(
R-HSA-3928665
)
R-HSA-3928628
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928633
(
R-HSA-3928664
)
R-HSA-3928633
Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it
See in Reactome
R-HSA-3928640
(
R-HSA-3928664
)
R-HSA-3928641
(
R-HSA-3928664
)
R-HSA-3928642
(
R-HSA-3928665
)
R-HSA-3928642
Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-399928
(
R-HSA-399955
)
R-HSA-399928
Reaction Name: Recruitment of Rnd1 to Plexin A
See in Reactome
R-HSA-399930
(
R-HSA-399954
)
R-HSA-399935
(
R-HSA-399955
)
R-HSA-399935
Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity
See in Reactome
R-HSA-399938
(
R-HSA-399955
)
R-HSA-399939
(
R-HSA-399954
)
R-HSA-399941
(
R-HSA-399955
)
R-HSA-399952
(
R-HSA-399954
)
R-HSA-399952
Reaction Name: Phosphorylation of LIMK-1 by PAK
See in Reactome
R-HSA-400682
(
R-HSA-416550
)
R-HSA-400682
Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D
See in Reactome
R-HSA-4093336
(
R-HSA-3928662
)
R-HSA-4093336
Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-428522
(
R-HSA-428543
)
R-HSA-428535
(
R-HSA-428540
)
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442592
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-442592
Reaction Name: WASPs or WAVEs activate the ARP2/3 complex
See in Reactome
R-HSA-445064
(
R-HSA-445144
)
R-HSA-445072
(
R-HSA-445144
)
R-HSA-445072
Reaction Name: Interaction of PAK1 with Rac1-GTP
See in Reactome
R-HSA-451347
(
R-HSA-376172
)
R-HSA-451366
(
R-HSA-376172
)
R-HSA-5218827
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218827
Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1
See in Reactome
R-HSA-5218839
(
R-HSA-4420097
)
R-HSA-5218839
Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1
See in Reactome
R-HSA-5218841
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218841
Reaction Name: NADPH oxidase 2 generates superoxide from oxygen
See in Reactome
R-HSA-5218850
(
R-HSA-4420097
)
R-HSA-5218850
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-5357445
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357472
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357483
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5626469
(
R-HSA-5626467
)
R-HSA-5626469
Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs
See in Reactome
R-HSA-5626507
(
R-HSA-5626467
)
R-HSA-5626507
Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin
See in Reactome
R-HSA-5626549
(
R-HSA-5626467
)
R-HSA-5627775
(
R-HSA-5627123;
R-HSA-5687128
)
R-HSA-5627775
Reaction Name: Autophosphorylation of PAK1,2,3
See in Reactome
R-HSA-5663232
(
R-HSA-5663220
)
R-HSA-5665659
(
R-HSA-5663220
)
R-HSA-5665659
Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin
See in Reactome
R-HSA-5665802
(
R-HSA-5663220
)
R-HSA-5665802
Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin
See in Reactome
R-HSA-5665809
(
R-HSA-5663220
)
R-HSA-5665809
Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments
See in Reactome
R-HSA-5668714
(
R-HSA-5668599
)
R-HSA-5668718
(
R-HSA-5668599
)
R-HSA-5668718
Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen
See in Reactome
R-HSA-5668731
(
R-HSA-5668599
)
R-HSA-5668731
Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen
See in Reactome
R-HSA-5668735
(
R-HSA-5668599
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5672304
(
R-HSA-5626467
)
R-HSA-5672304
Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1
See in Reactome
R-HSA-5672329
(
R-HSA-5626467
)
R-HSA-5672329
Reaction Name: IQGAP1 binds CLIP1 and microtubules
See in Reactome
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8848618
(
R-HSA-8849471
)
R-HSA-8848618
Reaction Name: Activation of RAC1 by the PXN:CRK complex
See in Reactome
R-HSA-8875591
(
R-HSA-8875555
)
R-HSA-8951586
(
R-HSA-4420097
)
R-HSA-8951586
Reaction Name: p-VAV family:PIP3 binds RAC1:GDP
See in Reactome
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981926
(
R-HSA-5627123
)
R-HSA-8981931
(
R-HSA-5627123
)
R-HSA-9013143
(
R-HSA-9013149
)
R-HSA-9013144
(
R-HSA-9013149
)
R-HSA-9013144
Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9013147
(
R-HSA-9013149
)
R-HSA-9013147
Reaction Name: RAC1 GDIs block activation of RAC1
See in Reactome
R-HSA-9032798
(
R-HSA-9032759
)
R-HSA-9033292
(
R-HSA-9032845
)
R-HSA-9033292
Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1
See in Reactome
R-HSA-9619803
(
R-HSA-9619229
)
R-HSA-9691168
(
R-HSA-9013149
)
R-HSA-9691168
Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane
See in Reactome
R-HSA-9691174
(
R-HSA-9013149
)
R-HSA-9691174
Reaction Name: RAC1 binds effectors at the ER membrane
See in Reactome
|
MONDO:0010389 |
CYBB |
P04839 |
1.-.-.-
|
R-HSA-1222556
R-HSA-1222556
Reactome Name: ROS and RNS production in phagocytes
See in Reactome
R-HSA-4420097
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-1236973
R-HSA-1236973
Reactome Name: Cross-presentation of particulate exogenous antigens (phagosomes)
See in Reactome
R-HSA-9013423
R-HSA-6798695
R-HSA-9013404
R-HSA-3299685
R-HSA-3299685
Reactome Name: Detoxification of Reactive Oxygen Species
See in Reactome
R-HSA-9013149
|
R-HSA-195258
R-HSA-8953897
R-HSA-9012999
R-HSA-194138
R-HSA-168256
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-194315
R-HSA-2262752
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-168249
R-HSA-9711123
R-HSA-9711123
Reactome Name: Cellular response to chemical stress
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-1280218
R-HSA-162582
|
Cellular responses to stimuli
Immune System
Signal Transduction
|
R-HSA-1222376
(
R-HSA-3299685
)
R-HSA-1222376
Reaction Name: NOX2 generates superoxide from oxygen
See in Reactome
R-HSA-1236967
(
R-HSA-1236973
)
R-HSA-1236967
Reaction Name: Alkalization of the phagosomal lumen by NOX2
See in Reactome
R-HSA-5218827
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218827
Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1
See in Reactome
R-HSA-5218841
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218841
Reaction Name: NADPH oxidase 2 generates superoxide from oxygen
See in Reactome
R-HSA-5668605
(
R-HSA-5668599
)
R-HSA-5668629
(
R-HSA-5668599
)
R-HSA-5668629
Reaction Name: Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP
See in Reactome
R-HSA-6789092
(
R-HSA-1222556
)
R-HSA-6789092
Reaction Name: NOX2 generates superoxide anion from oxygen
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-6799350
(
R-HSA-6798695
)
R-HSA-6799350
Reaction Name: Exocytosis of specific granule membrane proteins
See in Reactome
R-HSA-6807557
(
R-HSA-3299685
)
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014424
(
R-HSA-9013404
)
R-HSA-9014424
Reaction Name: RAC2 binds effectors at the phagocytic vesicle membrane
See in Reactome
R-HSA-9018808
(
R-HSA-9013423
)
R-HSA-9018808
Reaction Name: RAC3 binds effectors at the plasma membrane
See in Reactome
R-HSA-9626848
(
R-HSA-5668599
)
R-HSA-9626848
Reaction Name: S100A8:S100A9:AA:Ca(2+) binds NOX2 complex
See in Reactome
|
MONDO:0010407 |
HUWE1 |
Q7Z6Z7 |
2.3.2.26
|
R-HSA-6798695
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
|
R-HSA-168249
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-168256
R-HSA-1280218
|
Immune System
|
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-983140
(
R-HSA-983168
)
R-HSA-983140
Reaction Name: Transfer of Ub from E2 to substrate and release of E2
See in Reactome
R-HSA-983147
(
R-HSA-983168
)
R-HSA-983147
Reaction Name: Release of E3 from polyubiquitinated substrate
See in Reactome
R-HSA-983156
(
R-HSA-983168
)
R-HSA-983156
Reaction Name: Polyubiquitination of substrate
See in Reactome
R-HSA-983157
(
R-HSA-983168
)
R-HSA-983157
Reaction Name: Interaction of E3 with substrate and E2-Ub complex
See in Reactome
|
MONDO:0010497 |
DDX3X |
O00571 |
3.6.4.13
|
R-HSA-6798695
|
R-HSA-168249
R-HSA-168256
|
Immune System
|
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
|
MONDO:0010526 |
GLA |
P06280 |
3.2.1.22
|
R-HSA-6798695
R-HSA-1660662
|
R-HSA-556833
R-HSA-168249
R-HSA-1430728
R-HSA-168256
R-HSA-428157
|
Metabolism
Immune System
|
R-HSA-1605736
(
R-HSA-1660662
)
R-HSA-1605736
Reaction Name: Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
|
MONDO:0010600 |
CYBB |
P04839 |
1.-.-.-
|
R-HSA-1222556
R-HSA-1222556
Reactome Name: ROS and RNS production in phagocytes
See in Reactome
R-HSA-4420097
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-1236973
R-HSA-1236973
Reactome Name: Cross-presentation of particulate exogenous antigens (phagosomes)
See in Reactome
R-HSA-9013423
R-HSA-6798695
R-HSA-9013404
R-HSA-3299685
R-HSA-3299685
Reactome Name: Detoxification of Reactive Oxygen Species
See in Reactome
R-HSA-9013149
|
R-HSA-195258
R-HSA-8953897
R-HSA-9012999
R-HSA-194138
R-HSA-168256
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-194315
R-HSA-2262752
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-168249
R-HSA-9711123
R-HSA-9711123
Reactome Name: Cellular response to chemical stress
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-1280218
R-HSA-162582
|
Cellular responses to stimuli
Immune System
Signal Transduction
|
R-HSA-1222376
(
R-HSA-3299685
)
R-HSA-1222376
Reaction Name: NOX2 generates superoxide from oxygen
See in Reactome
R-HSA-1236967
(
R-HSA-1236973
)
R-HSA-1236967
Reaction Name: Alkalization of the phagosomal lumen by NOX2
See in Reactome
R-HSA-5218827
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218827
Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1
See in Reactome
R-HSA-5218841
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218841
Reaction Name: NADPH oxidase 2 generates superoxide from oxygen
See in Reactome
R-HSA-5668605
(
R-HSA-5668599
)
R-HSA-5668629
(
R-HSA-5668599
)
R-HSA-5668629
Reaction Name: Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP
See in Reactome
R-HSA-6789092
(
R-HSA-1222556
)
R-HSA-6789092
Reaction Name: NOX2 generates superoxide anion from oxygen
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-6799350
(
R-HSA-6798695
)
R-HSA-6799350
Reaction Name: Exocytosis of specific granule membrane proteins
See in Reactome
R-HSA-6807557
(
R-HSA-3299685
)
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014424
(
R-HSA-9013404
)
R-HSA-9014424
Reaction Name: RAC2 binds effectors at the phagocytic vesicle membrane
See in Reactome
R-HSA-9018808
(
R-HSA-9013423
)
R-HSA-9018808
Reaction Name: RAC3 binds effectors at the plasma membrane
See in Reactome
R-HSA-9626848
(
R-HSA-5668599
)
R-HSA-9626848
Reaction Name: S100A8:S100A9:AA:Ca(2+) binds NOX2 complex
See in Reactome
|
MONDO:0010857 |
MONDO:0010857
Disease Name: semantic dementia
OMIM id: OMIM:600274
Orphanet id: Orphanet:282
All associated enzymes in DAR:
PSEN1
. The disease is also associated to other non-enzyme proteins (not in DAR).
PSEN1 |
P49768 |
3.4.23.-
|
R-HSA-9013507
R-HSA-9013507
Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus
See in Reactome
R-HSA-193692
R-HSA-193692
Reactome Name: Regulated proteolysis of p75NTR
See in Reactome
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-1474228
R-HSA-1474228
Reactome Name: Degradation of the extracellular matrix
See in Reactome
R-HSA-205043
R-HSA-205043
Reactome Name: NRIF signals cell death from the nucleus
See in Reactome
R-HSA-9013700
R-HSA-9013700
Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus
See in Reactome
R-HSA-6798695
R-HSA-2122948
R-HSA-2122948
Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus
See in Reactome
R-HSA-9017802
R-HSA-9017802
Reactome Name: Noncanonical activation of NOTCH3
See in Reactome
R-HSA-1251985
R-HSA-2979096
R-HSA-2979096
Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus
See in Reactome
|
R-HSA-204998
R-HSA-204998
Reactome Name: Cell death signalling via NRAGE, NRIF and NADE
See in Reactome
R-HSA-1980143
R-HSA-9012852
R-HSA-1980145
R-HSA-168249
R-HSA-168256
R-HSA-9675108
R-HSA-9013694
R-HSA-157118
R-HSA-1474244
R-HSA-1474244
Reactome Name: Extracellular matrix organization
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-73887
R-HSA-1236394
R-HSA-422475
R-HSA-2682334
R-HSA-1266738
|
Immune System
Extracellular matrix organization
Signal Transduction
Developmental Biology
|
R-HSA-1251997
(
R-HSA-1251985
)
R-HSA-1251997
Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex
See in Reactome
R-HSA-157353
(
R-HSA-2122948
)
R-HSA-157353
Reaction Name: NEXT1 is cleaved to produce NICD1
See in Reactome
R-HSA-157640
(
R-HSA-2979096
)
R-HSA-157640
Reaction Name: NEXT2 is cleaved to produce NICD2
See in Reactome
R-HSA-193682
(
R-HSA-193692
)
R-HSA-193682
Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain
See in Reactome
R-HSA-1980109
(
R-HSA-2122948
)
R-HSA-1980109
Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1
See in Reactome
R-HSA-1980112
(
R-HSA-2122948
)
R-HSA-1980112
Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1
See in Reactome
R-HSA-205112
(
R-HSA-205043
)
R-HSA-205112
Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6
See in Reactome
R-HSA-2534206
(
R-HSA-1474228
)
R-HSA-2534206
Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase)
See in Reactome
R-HSA-2974731
(
R-HSA-2979096
)
R-HSA-2974731
Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2
See in Reactome
R-HSA-3928656
(
R-HSA-3928665
)
R-HSA-6798739
(
R-HSA-6798695
)
R-HSA-6798739
Reaction Name: Exocytosis of azurophil granule membrane proteins
See in Reactome
R-HSA-9013361
(
R-HSA-9013507
)
R-HSA-9013361
Reaction Name: NEXT3 is cleaved to produce NICD3
See in Reactome
R-HSA-9017817
(
R-HSA-9013507;
R-HSA-9017802
)
R-HSA-9017817
Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3
See in Reactome
R-HSA-9604294
(
R-HSA-9013700
)
R-HSA-9604294
Reaction Name: Gamma-secretase cleaves NOTCH4
See in Reactome
|
MONDO:0010949 |
RAB7A |
P51149 |
3.6.5.2
|
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-9013423
R-HSA-9013407
R-HSA-9013409
R-HSA-8873719
R-HSA-8854214
R-HSA-9035034
R-HSA-9013408
R-HSA-2132295
R-HSA-2132295
Reactome Name: MHC class II antigen presentation
See in Reactome
R-HSA-9013406
R-HSA-6798695
R-HSA-9013404
R-HSA-9013405
R-HSA-9013149
R-HSA-9013148
|
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-9012999
R-HSA-168249
R-HSA-168256
R-HSA-194315
R-HSA-392499
R-HSA-199991
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-9007101
R-HSA-1280218
R-HSA-162582
R-HSA-5653656
|
Immune System
Metabolism of proteins
Signal Transduction
Vesicle-mediated transport
|
R-HSA-2213248
(
R-HSA-2132295
)
R-HSA-2213248
Reaction Name: Transport of antigen loaded MHC II molecules to surface
See in Reactome
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-8854255
(
R-HSA-8854214
)
R-HSA-8854255
Reaction Name: TBC1D2A accelerates GTP hydrolysis by RAB7
See in Reactome
R-HSA-8854329
(
R-HSA-8854214
)
R-HSA-8854329
Reaction Name: TBC1D15 accelerates GTP hydrolysis by RAB7
See in Reactome
R-HSA-8870466
(
R-HSA-8873719
)
R-HSA-8870469
(
R-HSA-8873719
)
R-HSA-8870469
Reaction Name: RGGT geranylgeranylates RAB proteins
See in Reactome
R-HSA-8877451
(
R-HSA-8876198
)
R-HSA-8877451
Reaction Name: MON1:CCZ1 exchanges GTP for GDP on RAB7
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9013157
(
R-HSA-9013148
)
R-HSA-9013157
Reaction Name: CDC42 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014449
(
R-HSA-9013408
)
R-HSA-9014449
Reaction Name: RHOG binds effectors at the plasma membrane
See in Reactome
R-HSA-9017507
(
R-HSA-9013409
)
R-HSA-9017507
Reaction Name: RHOJ binds effectors at the plasma membrane
See in Reactome
R-HSA-9018746
(
R-HSA-9013406
)
R-HSA-9018746
Reaction Name: RHOQ binds effectors at the plasma membrane
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9018808
(
R-HSA-9013423
)
R-HSA-9018808
Reaction Name: RAC3 binds effectors at the plasma membrane
See in Reactome
R-HSA-9693125
(
R-HSA-9035034
)
R-HSA-9693125
Reaction Name: RHOF binds effectors at the plasma membrane
See in Reactome
R-HSA-9693198
(
R-HSA-9013405
)
R-HSA-9693198
Reaction Name: RHOD binds effectors at the plasma membrane
See in Reactome
|
MONDO:0011136 |
PLAU |
P00749 |
3.4.21.73
|
R-HSA-6798695
R-HSA-75205
|
R-HSA-168256
R-HSA-168249
R-HSA-109582
|
Immune System
Hemostasis
|
R-HSA-158925
(
R-HSA-75205
)
R-HSA-158925
Reaction Name: plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)
See in Reactome
R-HSA-158942
(
R-HSA-75205
)
R-HSA-158942
Reaction Name: urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR
See in Reactome
R-HSA-158959
(
R-HSA-75205
)
R-HSA-158959
Reaction Name: urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR
See in Reactome
R-HSA-158982
(
R-HSA-75205
)
R-HSA-158982
Reaction Name: plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)
See in Reactome
R-HSA-159001
(
R-HSA-75205
)
R-HSA-159001
Reaction Name: urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR
See in Reactome
R-HSA-159005
(
R-HSA-75205
)
R-HSA-159005
Reaction Name: urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-6799350
(
R-HSA-6798695
)
R-HSA-6799350
Reaction Name: Exocytosis of specific granule membrane proteins
See in Reactome
|
MONDO:0011429 |
MIF |
P14174 |
5.3.3.12
5.3.2.1
|
R-HSA-6798695
R-HSA-8950505
R-HSA-8950505
Reactome Name: Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
|
R-HSA-449147
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-168249
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9020591
R-HSA-109582
|
Immune System
Hemostasis
|
R-HSA-5676133
(
R-HSA-202733
)
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-8950732
(
R-HSA-8950505
)
R-HSA-8950732
Reaction Name: Expression of Macrophage migration inhibitory factor
See in Reactome
|
MONDO:0011743 |
PSEN1 |
P49768 |
3.4.23.-
|
R-HSA-9013507
R-HSA-9013507
Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus
See in Reactome
R-HSA-193692
R-HSA-193692
Reactome Name: Regulated proteolysis of p75NTR
See in Reactome
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-1474228
R-HSA-1474228
Reactome Name: Degradation of the extracellular matrix
See in Reactome
R-HSA-205043
R-HSA-205043
Reactome Name: NRIF signals cell death from the nucleus
See in Reactome
R-HSA-9013700
R-HSA-9013700
Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus
See in Reactome
R-HSA-6798695
R-HSA-2122948
R-HSA-2122948
Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus
See in Reactome
R-HSA-9017802
R-HSA-9017802
Reactome Name: Noncanonical activation of NOTCH3
See in Reactome
R-HSA-1251985
R-HSA-2979096
R-HSA-2979096
Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus
See in Reactome
|
R-HSA-204998
R-HSA-204998
Reactome Name: Cell death signalling via NRAGE, NRIF and NADE
See in Reactome
R-HSA-1980143
R-HSA-9012852
R-HSA-1980145
R-HSA-168249
R-HSA-168256
R-HSA-9675108
R-HSA-9013694
R-HSA-157118
R-HSA-1474244
R-HSA-1474244
Reactome Name: Extracellular matrix organization
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-73887
R-HSA-1236394
R-HSA-422475
R-HSA-2682334
R-HSA-1266738
|
Immune System
Extracellular matrix organization
Signal Transduction
Developmental Biology
|
R-HSA-1251997
(
R-HSA-1251985
)
R-HSA-1251997
Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex
See in Reactome
R-HSA-157353
(
R-HSA-2122948
)
R-HSA-157353
Reaction Name: NEXT1 is cleaved to produce NICD1
See in Reactome
R-HSA-157640
(
R-HSA-2979096
)
R-HSA-157640
Reaction Name: NEXT2 is cleaved to produce NICD2
See in Reactome
R-HSA-193682
(
R-HSA-193692
)
R-HSA-193682
Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain
See in Reactome
R-HSA-1980109
(
R-HSA-2122948
)
R-HSA-1980109
Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1
See in Reactome
R-HSA-1980112
(
R-HSA-2122948
)
R-HSA-1980112
Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1
See in Reactome
R-HSA-205112
(
R-HSA-205043
)
R-HSA-205112
Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6
See in Reactome
R-HSA-2534206
(
R-HSA-1474228
)
R-HSA-2534206
Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase)
See in Reactome
R-HSA-2974731
(
R-HSA-2979096
)
R-HSA-2974731
Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2
See in Reactome
R-HSA-3928656
(
R-HSA-3928665
)
R-HSA-6798739
(
R-HSA-6798695
)
R-HSA-6798739
Reaction Name: Exocytosis of azurophil granule membrane proteins
See in Reactome
R-HSA-9013361
(
R-HSA-9013507
)
R-HSA-9013361
Reaction Name: NEXT3 is cleaved to produce NICD3
See in Reactome
R-HSA-9017817
(
R-HSA-9013507;
R-HSA-9017802
)
R-HSA-9017817
Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3
See in Reactome
R-HSA-9604294
(
R-HSA-9013700
)
R-HSA-9604294
Reaction Name: Gamma-secretase cleaves NOTCH4
See in Reactome
|
MONDO:0011772 |
B4GALT1 |
P15291 |
2.4.1.90
2.4.1.-
2.4.1.275
2.4.1.38
2.4.1.22
|
R-HSA-2022854
R-HSA-5653890
R-HSA-6798695
R-HSA-1912420
R-HSA-2534343
R-HSA-2534343
Reactome Name: Interaction With Cumulus Cells And The Zona Pellucida
See in Reactome
R-HSA-975577
|
R-HSA-71387
R-HSA-1638074
R-HSA-1638074
Reactome Name: Keratan sulfate/keratin metabolism
See in Reactome
R-HSA-168249
R-HSA-168256
R-HSA-392499
R-HSA-157118
R-HSA-1187000
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-1430728
R-HSA-1630316
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-948021
R-HSA-948021
Reactome Name: Transport to the Golgi and subsequent modification
See in Reactome
R-HSA-1474165
R-HSA-1912422
R-HSA-1912422
Reactome Name: Pre-NOTCH Expression and Processing
See in Reactome
R-HSA-162582
R-HSA-975576
R-HSA-975576
Reactome Name: N-glycan antennae elongation in the medial/trans-Golgi
See in Reactome
|
Immune System
Metabolism of proteins
Metabolism
Reproduction
Signal Transduction
|
R-HSA-1297338
(
R-HSA-2534343
)
R-HSA-1297338
Reaction Name: Association of ADAM and B4GALT1 With ZP3
See in Reactome
R-HSA-1912352
(
R-HSA-1912420
)
R-HSA-2025723
(
R-HSA-2022854
)
R-HSA-2025723
Reaction Name: B4GALTs transfer Gal to the N-glycan precursor
See in Reactome
R-HSA-2046265
(
R-HSA-2022854
)
R-HSA-2046265
Reaction Name: B4GALTs transfer Gal to the keratan chain
See in Reactome
R-HSA-2046298
(
R-HSA-2022854
)
R-HSA-2046298
Reaction Name: B4GALTs transfer Gal to a branch of keratan
See in Reactome
R-HSA-5653878
(
R-HSA-5653890
)
R-HSA-5653878
Reaction Name: B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac
See in Reactome
R-HSA-5653886
(
R-HSA-5653890
)
R-HSA-6798739
(
R-HSA-6798695
)
R-HSA-6798739
Reaction Name: Exocytosis of azurophil granule membrane proteins
See in Reactome
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-975919
(
R-HSA-975577
)
R-HSA-975919
Reaction Name: Addition of galactose by beta 4-galactosyltransferases
See in Reactome
|
MONDO:0011872 |
RAB27A |
P51159 |
3.6.5.2
|
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-264876
R-HSA-8873719
R-HSA-6798695
|
R-HSA-168256
R-HSA-168249
R-HSA-392499
R-HSA-199991
R-HSA-2980736
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-9007101
R-HSA-5653656
|
Immune System
Metabolism of proteins
Vesicle-mediated transport
|
R-HSA-6798749
(
R-HSA-6798695
)
R-HSA-6798749
Reaction Name: Exocytosis of specific granule lumen proteins
See in Reactome
R-HSA-8870466
(
R-HSA-8873719
)
R-HSA-8870469
(
R-HSA-8873719
)
R-HSA-8870469
Reaction Name: RGGT geranylgeranylates RAB proteins
See in Reactome
R-HSA-8877308
(
R-HSA-8876198
)
R-HSA-8877308
Reaction Name: MADD exchanges GTP for GDP on RAB27
See in Reactome
R-HSA-9023171
(
R-HSA-264876
)
R-HSA-9023171
Reaction Name: Insulin secretory granule translocates across the cortical actin network
See in Reactome
|
MONDO:0011873 |
NPC2 |
P61916 |
-
|
R-HSA-6798695
R-HSA-8964038
|
R-HSA-168249
R-HSA-168256
R-HSA-174824
R-HSA-174824
Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance
See in Reactome
R-HSA-8964043
R-HSA-382551
|
Immune System
Transport of small molecules
|
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-8876472
(
R-HSA-8964038
)
R-HSA-8876484
(
R-HSA-8964038
)
|
MONDO:0011908 |
NRAS |
P01111 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-6798695
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-202733;
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392;
R-HSA-881907
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
|
MONDO:0011913 |
PSEN1 |
P49768 |
3.4.23.-
|
R-HSA-9013507
R-HSA-9013507
Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus
See in Reactome
R-HSA-193692
R-HSA-193692
Reactome Name: Regulated proteolysis of p75NTR
See in Reactome
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-1474228
R-HSA-1474228
Reactome Name: Degradation of the extracellular matrix
See in Reactome
R-HSA-205043
R-HSA-205043
Reactome Name: NRIF signals cell death from the nucleus
See in Reactome
R-HSA-9013700
R-HSA-9013700
Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus
See in Reactome
R-HSA-6798695
R-HSA-2122948
R-HSA-2122948
Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus
See in Reactome
R-HSA-9017802
R-HSA-9017802
Reactome Name: Noncanonical activation of NOTCH3
See in Reactome
R-HSA-1251985
R-HSA-2979096
R-HSA-2979096
Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus
See in Reactome
|
R-HSA-204998
R-HSA-204998
Reactome Name: Cell death signalling via NRAGE, NRIF and NADE
See in Reactome
R-HSA-1980143
R-HSA-9012852
R-HSA-1980145
R-HSA-168249
R-HSA-168256
R-HSA-9675108
R-HSA-9013694
R-HSA-157118
R-HSA-1474244
R-HSA-1474244
Reactome Name: Extracellular matrix organization
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-73887
R-HSA-1236394
R-HSA-422475
R-HSA-2682334
R-HSA-1266738
|
Immune System
Extracellular matrix organization
Signal Transduction
Developmental Biology
|
R-HSA-1251997
(
R-HSA-1251985
)
R-HSA-1251997
Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex
See in Reactome
R-HSA-157353
(
R-HSA-2122948
)
R-HSA-157353
Reaction Name: NEXT1 is cleaved to produce NICD1
See in Reactome
R-HSA-157640
(
R-HSA-2979096
)
R-HSA-157640
Reaction Name: NEXT2 is cleaved to produce NICD2
See in Reactome
R-HSA-193682
(
R-HSA-193692
)
R-HSA-193682
Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain
See in Reactome
R-HSA-1980109
(
R-HSA-2122948
)
R-HSA-1980109
Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1
See in Reactome
R-HSA-1980112
(
R-HSA-2122948
)
R-HSA-1980112
Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1
See in Reactome
R-HSA-205112
(
R-HSA-205043
)
R-HSA-205112
Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6
See in Reactome
R-HSA-2534206
(
R-HSA-1474228
)
R-HSA-2534206
Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase)
See in Reactome
R-HSA-2974731
(
R-HSA-2979096
)
R-HSA-2974731
Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2
See in Reactome
R-HSA-3928656
(
R-HSA-3928665
)
R-HSA-6798739
(
R-HSA-6798695
)
R-HSA-6798739
Reaction Name: Exocytosis of azurophil granule membrane proteins
See in Reactome
R-HSA-9013361
(
R-HSA-9013507
)
R-HSA-9013361
Reaction Name: NEXT3 is cleaved to produce NICD3
See in Reactome
R-HSA-9017817
(
R-HSA-9013507;
R-HSA-9017802
)
R-HSA-9017817
Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3
See in Reactome
R-HSA-9604294
(
R-HSA-9013700
)
R-HSA-9604294
Reaction Name: Gamma-secretase cleaves NOTCH4
See in Reactome
|
MONDO:0011951 |
VCP |
P55072 |
3.6.4.6
|
R-HSA-3371511
R-HSA-9646399
R-HSA-110320
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5358346
R-HSA-9013407
R-HSA-532668
R-HSA-532668
Reactome Name: N-glycan trimming in the ER and Calnexin/Calreticulin cycle
See in Reactome
R-HSA-6798695
R-HSA-8876725
R-HSA-8866654
R-HSA-8866654
Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins
See in Reactome
R-HSA-5689877
|
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-382551
R-HSA-5358351
R-HSA-8953897
R-HSA-2262752
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-9612973
R-HSA-168249
R-HSA-9663891
R-HSA-392499
R-HSA-110313
R-HSA-110313
Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
See in Reactome
R-HSA-8852135
R-HSA-1632852
R-HSA-5688426
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-73894
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-162582
R-HSA-73893
|
Immune System
Transport of small molecules
Cellular responses to stimuli
Autophagy
Metabolism of proteins
DNA Repair
Signal Transduction
|
R-HSA-5324632
(
R-HSA-3371511
)
R-HSA-5324632
Reaction Name: Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates
See in Reactome
R-HSA-5362412
(
R-HSA-5358346
)
R-HSA-5362412
Reaction Name: SYVN1 ubiquitinates Hh C-terminal fragments
See in Reactome
R-HSA-5362441
(
R-HSA-5358346
)
R-HSA-5362441
Reaction Name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane
See in Reactome
R-HSA-5362459
(
R-HSA-5358346
)
R-HSA-5362459
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol
See in Reactome
R-HSA-5654985
(
R-HSA-110320
)
R-HSA-5654985
Reaction Name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH
See in Reactome
R-HSA-5654989
(
R-HSA-110320
)
R-HSA-5654989
Reaction Name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA
See in Reactome
R-HSA-5688834
(
R-HSA-5689877
)
R-HSA-6781953
(
R-HSA-5689896
)
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-8850594
(
R-HSA-532668
)
R-HSA-8850594
Reaction Name: Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins
See in Reactome
R-HSA-8866542
(
R-HSA-382556
)
R-HSA-8866542
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol
See in Reactome
R-HSA-8866546
(
R-HSA-382556
)
R-HSA-8866546
Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR
See in Reactome
R-HSA-8866551
(
R-HSA-382556
)
R-HSA-8866551
Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation
See in Reactome
R-HSA-8932276
(
R-HSA-8876725
)
R-HSA-8932276
Reaction Name: VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP
See in Reactome
R-HSA-8943080
(
R-HSA-8866654
)
R-HSA-8943080
Reaction Name: TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11
See in Reactome
R-HSA-8943083
(
R-HSA-8866654
)
R-HSA-8943083
Reaction Name: US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9646347
(
R-HSA-9646399
)
R-HSA-9646347
Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1
See in Reactome
R-HSA-9646354
(
R-HSA-9646399
)
R-HSA-9646354
Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex
See in Reactome
R-HSA-9755507
()
R-HSA-9755507
Reaction Name: UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex
See in Reactome
R-HSA-9758088
()
R-HSA-9758088
Reaction Name: UBXN7 binds VCP hexamer:UBF1:NPLOC4
See in Reactome
R-HSA-9758090
()
R-HSA-9758090
Reaction Name: Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation
See in Reactome
|
MONDO:0012031 |
CD36 |
P16671 |
-
|
R-HSA-1989781
R-HSA-1989781
Reactome Name: PPARA activates gene expression
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-434313
R-HSA-434313
Reactome Name: Intracellular metabolism of fatty acids regulates insulin secretion
See in Reactome
R-HSA-114608
R-HSA-1236973
R-HSA-1236973
Reactome Name: Cross-presentation of particulate exogenous antigens (phagosomes)
See in Reactome
R-HSA-381340
R-HSA-381340
Reactome Name: Transcriptional regulation of white adipocyte differentiation
See in Reactome
R-HSA-1236974
R-HSA-3000471
R-HSA-3000471
Reactome Name: Scavenging by Class B Receptors
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-6798695
R-HSA-5686938
R-HSA-5686938
Reactome Name: Regulation of TLR by endogenous ligand
See in Reactome
|
R-HSA-449147
R-HSA-400451
R-HSA-400451
Reactome Name: Free fatty acids regulate insulin secretion
See in Reactome
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-1430728
R-HSA-1280218
R-HSA-1266738
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-76005
R-HSA-76005
Reactome Name: Response to elevated platelet cytosolic Ca2+
See in Reactome
R-HSA-168898
R-HSA-556833
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-168249
R-HSA-163685
R-HSA-163685
Reactome Name: Integration of energy metabolism
See in Reactome
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-400206
R-HSA-400206
Reactome Name: Regulation of lipid metabolism by PPARalpha
See in Reactome
R-HSA-5653656
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-422356
R-HSA-422356
Reactome Name: Regulation of insulin secretion
See in Reactome
R-HSA-109582
R-HSA-2173782
R-HSA-2173782
Reactome Name: Binding and Uptake of Ligands by Scavenger Receptors
See in Reactome
|
Immune System
Metabolism
Developmental Biology
Vesicle-mediated transport
Hemostasis
|
R-HSA-1236956
(
R-HSA-1236973
)
R-HSA-1236956
Reaction Name: Engulfment of particulate antigen into phagocytic vesicle
See in Reactome
R-HSA-1236958
(
R-HSA-1236973
)
R-HSA-1236958
Reaction Name: Interaction of particulate antigens with dendritic cell receptors
See in Reactome
R-HSA-166072
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-166072
Reaction Name: MyD88 forms a complex with TIRAP:activated TLR2/4
See in Reactome
R-HSA-166082
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-166082
Reaction Name: IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex
See in Reactome
R-HSA-166091
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-166091
Reaction Name: IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex
See in Reactome
R-HSA-166119
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-166119
Reaction Name: First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal
See in Reactome
R-HSA-166284
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-166284
Reaction Name: Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP
See in Reactome
R-HSA-166286
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-166286
Reaction Name: Multiple IRAK1 autophosphorylation steps
See in Reactome
R-HSA-166362
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-166362
Reaction Name: Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
See in Reactome
R-HSA-166363
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-168950
(
R-HSA-168188
)
R-HSA-168950
Reaction Name: TLR6:TLR2 is recruited to ligand:CD14:CD36
See in Reactome
R-HSA-2187264
(
R-HSA-3000471
)
R-HSA-2187264
Reaction Name: Platelet glycoprotein IV (CD36) binds ligands
See in Reactome
R-HSA-2201316
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-2201316
Reaction Name: Activated TLR2/4 interacts with MAL (TIRAP)
See in Reactome
R-HSA-2201322
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-2201322
Reaction Name: TIRAP is phosphorylated by BTK
See in Reactome
R-HSA-2247512
(
R-HSA-3000471
)
R-HSA-2247512
Reaction Name: Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed
See in Reactome
R-HSA-2262775
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-2262775
Reaction Name: Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
See in Reactome
R-HSA-2262777
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-2559414
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-2559414
Reaction Name: Activated TLR2/4:TIRAP interacts with BTK
See in Reactome
R-HSA-2559464
(
R-HSA-168188
)
R-HSA-2559464
Reaction Name: TLR6/2 ligand associates with CD14 and CD36 within lipid rafts
See in Reactome
R-HSA-434381
(
R-HSA-434313
)
R-HSA-434381
Reaction Name: CD36 (FAT) translocates palmitate from the extracellular region to the cytosol
See in Reactome
R-HSA-481044
(
R-HSA-114608
)
R-HSA-481044
Reaction Name: Surface deployment of platelet alpha granule membrane components
See in Reactome
R-HSA-560517
(
R-HSA-1989781;
R-HSA-381340
)
R-HSA-560517
Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT)
See in Reactome
R-HSA-6797267
(
R-HSA-6785807
)
R-HSA-6799350
(
R-HSA-6798695
)
R-HSA-6799350
Reaction Name: Exocytosis of specific granule membrane proteins
See in Reactome
R-HSA-8863895
(
R-HSA-1236974
)
R-HSA-8869667
(
R-HSA-5686938
)
R-HSA-937022
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-937022
Reaction Name: IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP
See in Reactome
R-HSA-937059
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-937059
Reaction Name: Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex
See in Reactome
R-HSA-937079
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-937079
Reaction Name: MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88
See in Reactome
|
MONDO:0012071 |
AGPAT2 |
O15120 |
2.3.1.51
|
R-HSA-6798695
R-HSA-1483166
|
R-HSA-168256
R-HSA-168249
R-HSA-1483257
R-HSA-1483206
R-HSA-1483206
Reactome Name: Glycerophospholipid biosynthesis
See in Reactome
R-HSA-1430728
R-HSA-556833
|
Immune System
Metabolism
|
R-HSA-6799350
(
R-HSA-6798695
)
R-HSA-6799350
Reaction Name: Exocytosis of specific granule membrane proteins
See in Reactome
R-HSA-75885
(
R-HSA-1483166
)
R-HSA-75885
Reaction Name: 1-acyl LPA is acylated to PA by AGPAT (LPAAT)
See in Reactome
|
MONDO:0012163 |
PTPRC |
P08575 |
3.1.3.48
|
R-HSA-6798695
R-HSA-416700
R-HSA-202427
R-HSA-202427
Reactome Name: Phosphorylation of CD3 and TCR zeta chains
See in Reactome
|
R-HSA-168249
R-HSA-168256
R-HSA-9675108
R-HSA-202403
R-HSA-373755
R-HSA-422475
R-HSA-1280218
R-HSA-1266738
|
Immune System
Developmental Biology
|
R-HSA-202214
(
R-HSA-202427
)
R-HSA-202214
Reaction Name: Dephosphorylation of Lck-pY505 by CD45
See in Reactome
R-HSA-202233
(
R-HSA-202427
)
R-HSA-373746
(
R-HSA-416700
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
|
MONDO:0012414 |
CTSD |
P07339 |
3.4.23.5
|
R-HSA-9018519
R-HSA-9018519
Reactome Name: Estrogen-dependent gene expression
See in Reactome
R-HSA-6798695
R-HSA-2132295
R-HSA-2132295
Reactome Name: MHC class II antigen presentation
See in Reactome
R-HSA-2022377
R-HSA-2022377
Reactome Name: Metabolism of Angiotensinogen to Angiotensins
See in Reactome
R-HSA-1442490
|
R-HSA-168249
R-HSA-168256
R-HSA-1474228
R-HSA-1474228
Reactome Name: Degradation of the extracellular matrix
See in Reactome
R-HSA-2980736
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-1474244
R-HSA-1474244
Reactome Name: Extracellular matrix organization
See in Reactome
R-HSA-8939211
R-HSA-392499
R-HSA-1280218
R-HSA-162582
|
Immune System
Extracellular matrix organization
Metabolism of proteins
Signal Transduction
|
R-HSA-2022403
(
R-HSA-2022377
)
R-HSA-2022403
Reaction Name: Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)
See in Reactome
R-HSA-2022412
(
R-HSA-2022377
)
R-HSA-2022412
Reaction Name: Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10)
See in Reactome
R-HSA-2130349
(
R-HSA-2132295
)
R-HSA-2130504
(
R-HSA-2132295
)
R-HSA-2130706
(
R-HSA-2132295
)
R-HSA-2130706
Reaction Name: MHC class II antigen processing
See in Reactome
R-HSA-2471621
(
R-HSA-1442490
)
R-HSA-2471621
Reaction Name: Endostatin degradation by cathepsins
See in Reactome
R-HSA-6798745
(
R-HSA-6798695
)
R-HSA-6798745
Reaction Name: Exocytosis of tertiary granule lumen proteins
See in Reactome
R-HSA-6798749
(
R-HSA-6798695
)
R-HSA-6798749
Reaction Name: Exocytosis of specific granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-9023846
(
R-HSA-9018519
)
R-HSA-9023846
Reaction Name: Estrogen-responsive CTSD expression
See in Reactome
|
MONDO:0012585 |
CD36 |
P16671 |
-
|
R-HSA-1989781
R-HSA-1989781
Reactome Name: PPARA activates gene expression
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-434313
R-HSA-434313
Reactome Name: Intracellular metabolism of fatty acids regulates insulin secretion
See in Reactome
R-HSA-114608
R-HSA-1236973
R-HSA-1236973
Reactome Name: Cross-presentation of particulate exogenous antigens (phagosomes)
See in Reactome
R-HSA-381340
R-HSA-381340
Reactome Name: Transcriptional regulation of white adipocyte differentiation
See in Reactome
R-HSA-1236974
R-HSA-3000471
R-HSA-3000471
Reactome Name: Scavenging by Class B Receptors
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-6798695
R-HSA-5686938
R-HSA-5686938
Reactome Name: Regulation of TLR by endogenous ligand
See in Reactome
|
R-HSA-449147
R-HSA-400451
R-HSA-400451
Reactome Name: Free fatty acids regulate insulin secretion
See in Reactome
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-1430728
R-HSA-1280218
R-HSA-1266738
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-76005
R-HSA-76005
Reactome Name: Response to elevated platelet cytosolic Ca2+
See in Reactome
R-HSA-168898
R-HSA-556833
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-168249
R-HSA-163685
R-HSA-163685
Reactome Name: Integration of energy metabolism
See in Reactome
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-400206
R-HSA-400206
Reactome Name: Regulation of lipid metabolism by PPARalpha
See in Reactome
R-HSA-5653656
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-422356
R-HSA-422356
Reactome Name: Regulation of insulin secretion
See in Reactome
R-HSA-109582
R-HSA-2173782
R-HSA-2173782
Reactome Name: Binding and Uptake of Ligands by Scavenger Receptors
See in Reactome
|
Immune System
Metabolism
Developmental Biology
Vesicle-mediated transport
Hemostasis
|
R-HSA-1236956
(
R-HSA-1236973
)
R-HSA-1236956
Reaction Name: Engulfment of particulate antigen into phagocytic vesicle
See in Reactome
R-HSA-1236958
(
R-HSA-1236973
)
R-HSA-1236958
Reaction Name: Interaction of particulate antigens with dendritic cell receptors
See in Reactome
R-HSA-166072
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-166072
Reaction Name: MyD88 forms a complex with TIRAP:activated TLR2/4
See in Reactome
R-HSA-166082
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-166082
Reaction Name: IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex
See in Reactome
R-HSA-166091
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-166091
Reaction Name: IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex
See in Reactome
R-HSA-166119
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-166119
Reaction Name: First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal
See in Reactome
R-HSA-166284
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-166284
Reaction Name: Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP
See in Reactome
R-HSA-166286
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-166286
Reaction Name: Multiple IRAK1 autophosphorylation steps
See in Reactome
R-HSA-166362
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-166362
Reaction Name: Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
See in Reactome
R-HSA-166363
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-168950
(
R-HSA-168188
)
R-HSA-168950
Reaction Name: TLR6:TLR2 is recruited to ligand:CD14:CD36
See in Reactome
R-HSA-2187264
(
R-HSA-3000471
)
R-HSA-2187264
Reaction Name: Platelet glycoprotein IV (CD36) binds ligands
See in Reactome
R-HSA-2201316
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-2201316
Reaction Name: Activated TLR2/4 interacts with MAL (TIRAP)
See in Reactome
R-HSA-2201322
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-2201322
Reaction Name: TIRAP is phosphorylated by BTK
See in Reactome
R-HSA-2247512
(
R-HSA-3000471
)
R-HSA-2247512
Reaction Name: Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed
See in Reactome
R-HSA-2262775
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-2262775
Reaction Name: Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
See in Reactome
R-HSA-2262777
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-2559414
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-2559414
Reaction Name: Activated TLR2/4:TIRAP interacts with BTK
See in Reactome
R-HSA-2559464
(
R-HSA-168188
)
R-HSA-2559464
Reaction Name: TLR6/2 ligand associates with CD14 and CD36 within lipid rafts
See in Reactome
R-HSA-434381
(
R-HSA-434313
)
R-HSA-434381
Reaction Name: CD36 (FAT) translocates palmitate from the extracellular region to the cytosol
See in Reactome
R-HSA-481044
(
R-HSA-114608
)
R-HSA-481044
Reaction Name: Surface deployment of platelet alpha granule membrane components
See in Reactome
R-HSA-560517
(
R-HSA-1989781;
R-HSA-381340
)
R-HSA-560517
Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT)
See in Reactome
R-HSA-6797267
(
R-HSA-6785807
)
R-HSA-6799350
(
R-HSA-6798695
)
R-HSA-6799350
Reaction Name: Exocytosis of specific granule membrane proteins
See in Reactome
R-HSA-8863895
(
R-HSA-1236974
)
R-HSA-8869667
(
R-HSA-5686938
)
R-HSA-937022
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-937022
Reaction Name: IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP
See in Reactome
R-HSA-937059
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-937059
Reaction Name: Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex
See in Reactome
R-HSA-937079
(
R-HSA-166058;
R-HSA-168188
)
R-HSA-937079
Reaction Name: MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88
See in Reactome
|
MONDO:0012747 |
ALDOA |
P04075 |
4.1.2.13
|
R-HSA-6798695
R-HSA-70171
R-HSA-114608
R-HSA-70263
|
R-HSA-70326
R-HSA-168256
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-168249
R-HSA-76005
R-HSA-76005
Reactome Name: Response to elevated platelet cytosolic Ca2+
See in Reactome
R-HSA-1430728
R-HSA-109582
R-HSA-71387
|
Immune System
Metabolism
Hemostasis
|
R-HSA-481007
(
R-HSA-114608
)
R-HSA-481007
Reaction Name: Exocytosis of platelet alpha granule contents
See in Reactome
R-HSA-6798745
(
R-HSA-6798695
)
R-HSA-6798745
Reaction Name: Exocytosis of tertiary granule lumen proteins
See in Reactome
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-71495
(
R-HSA-70263
)
R-HSA-71495
Reaction Name: dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate
See in Reactome
R-HSA-71496
(
R-HSA-70171
)
R-HSA-71496
Reaction Name: D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate
See in Reactome
|
MONDO:0013000 |
ALAD |
P13716 |
4.2.1.24
|
R-HSA-6798695
R-HSA-189451
|
R-HSA-168249
R-HSA-1430728
R-HSA-168256
R-HSA-189445
|
Metabolism
Immune System
|
R-HSA-189439
(
R-HSA-189451
)
R-HSA-189439
Reaction Name: ALAD condenses 2 dALAs to form PBG
See in Reactome
R-HSA-190141
(
R-HSA-189451
)
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
|
MONDO:0013058 |
RNASET2 |
O00584 |
4.6.1.19
|
R-HSA-6798695
|
R-HSA-168249
R-HSA-168256
|
Immune System
|
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
|
MONDO:0013113 |
MMP9 |
P14780 |
3.4.24.35
|
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-1474228
R-HSA-1474228
Reactome Name: Degradation of the extracellular matrix
See in Reactome
R-HSA-1433557
R-HSA-1592389
R-HSA-1592389
Reactome Name: Activation of Matrix Metalloproteinases
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-6798695
R-HSA-2022090
R-HSA-2022090
Reactome Name: Assembly of collagen fibrils and other multimeric structures
See in Reactome
R-HSA-1442490
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
|
R-HSA-449147
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-168249
R-HSA-168256
R-HSA-9675108
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-1474244
R-HSA-1474244
Reactome Name: Extracellular matrix organization
See in Reactome
R-HSA-8939211
R-HSA-162582
R-HSA-1474290
R-HSA-422475
R-HSA-2682334
R-HSA-1266738
|
Immune System
Extracellular matrix organization
Signal Transduction
Developmental Biology
|
R-HSA-1433374
(
R-HSA-1433557
)
R-HSA-1454757
(
R-HSA-1442490;
R-HSA-1474228
)
R-HSA-1454757
Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
See in Reactome
R-HSA-1454781
(
R-HSA-1474228
)
R-HSA-1454781
Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin
See in Reactome
R-HSA-1454791
(
R-HSA-1474228
)
R-HSA-1474213
(
R-HSA-1442490;
R-HSA-1474228
)
R-HSA-1474213
Reaction Name: Collagen type III degradation by MMP1,8,9,13
See in Reactome
R-HSA-1564112
(
R-HSA-1442490;
R-HSA-1474228
)
R-HSA-1564112
Reaction Name: Collagen type VI degradation by MMP2,9,11
See in Reactome
R-HSA-1564117
(
R-HSA-1442490;
R-HSA-1474228
)
R-HSA-1564117
Reaction Name: Collagen type XIV degradation by MMP9,13
See in Reactome
R-HSA-1564142
(
R-HSA-1442490;
R-HSA-1474228
)
R-HSA-1564142
Reaction Name: Collagen type IV degradation by MMP2,3,4,9,10,12
See in Reactome
R-HSA-1564164
(
R-HSA-1442490;
R-HSA-1474228
)
R-HSA-1564164
Reaction Name: Collagen type V degradation by MMP2,9,10
See in Reactome
R-HSA-1564179
(
R-HSA-1442490;
R-HSA-1474228
)
R-HSA-1564179
Reaction Name: Collagen type XI degradation by MMP1,2,3,9
See in Reactome
R-HSA-1566962
(
R-HSA-1474228
)
R-HSA-1566962
Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases
See in Reactome
R-HSA-1592270
(
R-HSA-1474228
)
R-HSA-1592270
Reaction Name: NID1 degradation by MMP1, 9, 12, ELANE
See in Reactome
R-HSA-1592436
(
R-HSA-1474228;
R-HSA-1592389
)
R-HSA-1592436
Reaction Name: Initial activation of proMMP9 by MMPs
See in Reactome
R-HSA-1602454
(
R-HSA-1474228;
R-HSA-1592389
)
R-HSA-1604690
(
R-HSA-1474228;
R-HSA-1592389
)
R-HSA-1604690
Reaction Name: Activation of MMP9 intermediate form by MMPs
See in Reactome
R-HSA-1604722
(
R-HSA-1474228;
R-HSA-1592389
)
R-HSA-1604722
Reaction Name: Activation of proMMP9 by proteases
See in Reactome
R-HSA-2168923
(
R-HSA-1442490;
R-HSA-1474228
)
R-HSA-2168923
Reaction Name: Collagen type XVIII endostatin release
See in Reactome
R-HSA-2168982
(
R-HSA-1442490;
R-HSA-1474228
)
R-HSA-2168982
Reaction Name: Collagen type XVI degradation by MMP9
See in Reactome
R-HSA-2213200
(
R-HSA-2022090
)
R-HSA-2213200
Reaction Name: Release of endostatin-like peptides
See in Reactome
R-HSA-2485148
(
R-HSA-1474228
)
R-HSA-2485148
Reaction Name: Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13
See in Reactome
R-HSA-3791295
(
R-HSA-1474228
)
R-HSA-3791295
Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13
See in Reactome
R-HSA-3827958
(
R-HSA-1474228
)
R-HSA-3827958
Reaction Name: E-cadherin degradation by MMP9, KLK7
See in Reactome
R-HSA-3928657
(
R-HSA-3928665
)
R-HSA-6789615
(
R-HSA-6785807
)
R-HSA-6789615
Reaction Name: Expression of STAT3-upregulated extracellular proteins
See in Reactome
R-HSA-6798745
(
R-HSA-6798695
)
R-HSA-6798745
Reaction Name: Exocytosis of tertiary granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-8943959
(
R-HSA-1474228
)
R-HSA-9624272
(
R-HSA-8939211;
R-HSA-9009391
)
|
MONDO:0013171 |
PNP |
P00491 |
2.4.2.1
|
R-HSA-6798695
R-HSA-74217
R-HSA-74259
|
R-HSA-8956319
R-HSA-168256
R-HSA-168249
R-HSA-8956321
R-HSA-1430728
R-HSA-15869
|
Immune System
Metabolism
|
R-HSA-112033
(
R-HSA-74217
)
R-HSA-112033
Reaction Name: PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine
See in Reactome
R-HSA-112034
(
R-HSA-74217
)
R-HSA-112034
Reaction Name: PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine
See in Reactome
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-74242
(
R-HSA-74259
)
R-HSA-74242
Reaction Name: PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose
See in Reactome
R-HSA-74249
(
R-HSA-74259
)
R-HSA-74249
Reaction Name: PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose
See in Reactome
|
MONDO:0013186 |
NRAS |
P01111 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-6798695
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-202733;
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392;
R-HSA-881907
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
|
MONDO:0013275 |
GPI |
P06744 |
5.3.1.9
|
R-HSA-6798695
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-70171
R-HSA-70263
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-70326
R-HSA-71387
R-HSA-212436
R-HSA-168249
R-HSA-168256
R-HSA-1430728
R-HSA-74160
R-HSA-73857
|
Immune System
Metabolism
Gene expression (Transcription)
|
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-70471
(
R-HSA-70171
)
R-HSA-70471
Reaction Name: alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate
See in Reactome
R-HSA-70475
(
R-HSA-5628897;
R-HSA-70263
)
R-HSA-70475
Reaction Name: D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate
See in Reactome
|
MONDO:0013291 |
GYG1 |
P46976 |
2.4.1.186
|
R-HSA-6798695
R-HSA-3322077
R-HSA-70221
R-HSA-70221
Reactome Name: Glycogen breakdown (glycogenolysis)
See in Reactome
|
R-HSA-1430728
R-HSA-168249
R-HSA-168256
R-HSA-8982491
R-HSA-71387
|
Metabolism
Immune System
|
R-HSA-3322001
(
R-HSA-3322077
)
R-HSA-3322001
Reaction Name: GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1
See in Reactome
R-HSA-3322003
(
R-HSA-3322077
)
R-HSA-3322003
Reaction Name: Autoglucosylation of GYG1 complexed with GYS1-b
See in Reactome
R-HSA-3322005
(
R-HSA-3322077
)
R-HSA-3322005
Reaction Name: GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a
See in Reactome
R-HSA-3322025
(
R-HSA-3322077
)
R-HSA-3322025
Reaction Name: Autoglucosylation of GYG1 complexed with GYS1-a
See in Reactome
R-HSA-3322041
(
R-HSA-3322077
)
R-HSA-3322041
Reaction Name: Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1
See in Reactome
R-HSA-3322057
(
R-HSA-3322077
)
R-HSA-3322057
Reaction Name: GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b
See in Reactome
R-HSA-3781001
(
R-HSA-3322077
)
R-HSA-3781001
Reaction Name: EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG1 complex
See in Reactome
R-HSA-3781009
(
R-HSA-3322077
)
R-HSA-3781009
Reaction Name: NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1
See in Reactome
R-HSA-3781018
(
R-HSA-3322077
)
R-HSA-3781018
Reaction Name: EPM2A dimer dephosphorylates phosphoglycogen-GYG1
See in Reactome
R-HSA-3781023
(
R-HSA-3322077
)
R-HSA-3781023
Reaction Name: PPP1R3C binds to glycogen:GYG1:GYS1
See in Reactome
R-HSA-3781024
(
R-HSA-3322077
)
R-HSA-3781024
Reaction Name: GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1
See in Reactome
R-HSA-453358
(
R-HSA-70221
)
R-HSA-453358
Reaction Name: poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]
See in Reactome
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-71515
(
R-HSA-70221
)
R-HSA-71515
Reaction Name: glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]
See in Reactome
R-HSA-71552
(
R-HSA-70221
)
R-HSA-71552
Reaction Name: limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin
See in Reactome
R-HSA-71593
(
R-HSA-70221
)
R-HSA-71593
Reaction Name: ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose
See in Reactome
R-HSA-9036727
(
R-HSA-70221
)
R-HSA-9036727
Reaction Name: GAA hydrolyzes lysosomal glycogen
See in Reactome
|
MONDO:0013371 |
PSEN1 |
P49768 |
3.4.23.-
|
R-HSA-9013507
R-HSA-9013507
Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus
See in Reactome
R-HSA-193692
R-HSA-193692
Reactome Name: Regulated proteolysis of p75NTR
See in Reactome
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-1474228
R-HSA-1474228
Reactome Name: Degradation of the extracellular matrix
See in Reactome
R-HSA-205043
R-HSA-205043
Reactome Name: NRIF signals cell death from the nucleus
See in Reactome
R-HSA-9013700
R-HSA-9013700
Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus
See in Reactome
R-HSA-6798695
R-HSA-2122948
R-HSA-2122948
Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus
See in Reactome
R-HSA-9017802
R-HSA-9017802
Reactome Name: Noncanonical activation of NOTCH3
See in Reactome
R-HSA-1251985
R-HSA-2979096
R-HSA-2979096
Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus
See in Reactome
|
R-HSA-204998
R-HSA-204998
Reactome Name: Cell death signalling via NRAGE, NRIF and NADE
See in Reactome
R-HSA-1980143
R-HSA-9012852
R-HSA-1980145
R-HSA-168249
R-HSA-168256
R-HSA-9675108
R-HSA-9013694
R-HSA-157118
R-HSA-1474244
R-HSA-1474244
Reactome Name: Extracellular matrix organization
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-73887
R-HSA-1236394
R-HSA-422475
R-HSA-2682334
R-HSA-1266738
|
Immune System
Extracellular matrix organization
Signal Transduction
Developmental Biology
|
R-HSA-1251997
(
R-HSA-1251985
)
R-HSA-1251997
Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex
See in Reactome
R-HSA-157353
(
R-HSA-2122948
)
R-HSA-157353
Reaction Name: NEXT1 is cleaved to produce NICD1
See in Reactome
R-HSA-157640
(
R-HSA-2979096
)
R-HSA-157640
Reaction Name: NEXT2 is cleaved to produce NICD2
See in Reactome
R-HSA-193682
(
R-HSA-193692
)
R-HSA-193682
Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain
See in Reactome
R-HSA-1980109
(
R-HSA-2122948
)
R-HSA-1980109
Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1
See in Reactome
R-HSA-1980112
(
R-HSA-2122948
)
R-HSA-1980112
Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1
See in Reactome
R-HSA-205112
(
R-HSA-205043
)
R-HSA-205112
Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6
See in Reactome
R-HSA-2534206
(
R-HSA-1474228
)
R-HSA-2534206
Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase)
See in Reactome
R-HSA-2974731
(
R-HSA-2979096
)
R-HSA-2974731
Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2
See in Reactome
R-HSA-3928656
(
R-HSA-3928665
)
R-HSA-6798739
(
R-HSA-6798695
)
R-HSA-6798739
Reaction Name: Exocytosis of azurophil granule membrane proteins
See in Reactome
R-HSA-9013361
(
R-HSA-9013507
)
R-HSA-9013361
Reaction Name: NEXT3 is cleaved to produce NICD3
See in Reactome
R-HSA-9017817
(
R-HSA-9013507;
R-HSA-9017802
)
R-HSA-9017817
Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3
See in Reactome
R-HSA-9604294
(
R-HSA-9013700
)
R-HSA-9604294
Reaction Name: Gamma-secretase cleaves NOTCH4
See in Reactome
|
MONDO:0013398 |
PSEN1 |
P49768 |
3.4.23.-
|
R-HSA-9013507
R-HSA-9013507
Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus
See in Reactome
R-HSA-193692
R-HSA-193692
Reactome Name: Regulated proteolysis of p75NTR
See in Reactome
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-1474228
R-HSA-1474228
Reactome Name: Degradation of the extracellular matrix
See in Reactome
R-HSA-205043
R-HSA-205043
Reactome Name: NRIF signals cell death from the nucleus
See in Reactome
R-HSA-9013700
R-HSA-9013700
Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus
See in Reactome
R-HSA-6798695
R-HSA-2122948
R-HSA-2122948
Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus
See in Reactome
R-HSA-9017802
R-HSA-9017802
Reactome Name: Noncanonical activation of NOTCH3
See in Reactome
R-HSA-1251985
R-HSA-2979096
R-HSA-2979096
Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus
See in Reactome
|
R-HSA-204998
R-HSA-204998
Reactome Name: Cell death signalling via NRAGE, NRIF and NADE
See in Reactome
R-HSA-1980143
R-HSA-9012852
R-HSA-1980145
R-HSA-168249
R-HSA-168256
R-HSA-9675108
R-HSA-9013694
R-HSA-157118
R-HSA-1474244
R-HSA-1474244
Reactome Name: Extracellular matrix organization
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-73887
R-HSA-1236394
R-HSA-422475
R-HSA-2682334
R-HSA-1266738
|
Immune System
Extracellular matrix organization
Signal Transduction
Developmental Biology
|
R-HSA-1251997
(
R-HSA-1251985
)
R-HSA-1251997
Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex
See in Reactome
R-HSA-157353
(
R-HSA-2122948
)
R-HSA-157353
Reaction Name: NEXT1 is cleaved to produce NICD1
See in Reactome
R-HSA-157640
(
R-HSA-2979096
)
R-HSA-157640
Reaction Name: NEXT2 is cleaved to produce NICD2
See in Reactome
R-HSA-193682
(
R-HSA-193692
)
R-HSA-193682
Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain
See in Reactome
R-HSA-1980109
(
R-HSA-2122948
)
R-HSA-1980109
Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1
See in Reactome
R-HSA-1980112
(
R-HSA-2122948
)
R-HSA-1980112
Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1
See in Reactome
R-HSA-205112
(
R-HSA-205043
)
R-HSA-205112
Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6
See in Reactome
R-HSA-2534206
(
R-HSA-1474228
)
R-HSA-2534206
Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase)
See in Reactome
R-HSA-2974731
(
R-HSA-2979096
)
R-HSA-2974731
Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2
See in Reactome
R-HSA-3928656
(
R-HSA-3928665
)
R-HSA-6798739
(
R-HSA-6798695
)
R-HSA-6798739
Reaction Name: Exocytosis of azurophil granule membrane proteins
See in Reactome
R-HSA-9013361
(
R-HSA-9013507
)
R-HSA-9013361
Reaction Name: NEXT3 is cleaved to produce NICD3
See in Reactome
R-HSA-9017817
(
R-HSA-9013507;
R-HSA-9017802
)
R-HSA-9017817
Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3
See in Reactome
R-HSA-9604294
(
R-HSA-9013700
)
R-HSA-9604294
Reaction Name: Gamma-secretase cleaves NOTCH4
See in Reactome
|
MONDO:0013454 |
IMPDH1 |
P20839 |
1.1.1.205
|
R-HSA-6798695
R-HSA-73817
R-HSA-73817
Reactome Name: Purine ribonucleoside monophosphate biosynthesis
See in Reactome
|
R-HSA-1430728
R-HSA-168256
R-HSA-168249
R-HSA-15869
R-HSA-8956320
|
Metabolism
Immune System
|
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-73794
(
R-HSA-73817
)
R-HSA-73794
Reaction Name: IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]
See in Reactome
R-HSA-9678749
(
R-HSA-73817
)
R-HSA-9678749
Reaction Name: IMPDH tetramers binds IMPDH inhibitors
See in Reactome
|
MONDO:0013487 |
CFD |
P00746 |
3.4.21.46
|
R-HSA-6798695
R-HSA-114608
R-HSA-173736
R-HSA-173736
Reactome Name: Alternative complement activation
See in Reactome
|
R-HSA-168249
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-168256
R-HSA-76005
R-HSA-76005
Reactome Name: Response to elevated platelet cytosolic Ca2+
See in Reactome
R-HSA-166658
R-HSA-166663
R-HSA-166663
Reactome Name: Initial triggering of complement
See in Reactome
R-HSA-109582
|
Immune System
Hemostasis
|
R-HSA-173745
(
R-HSA-173736
)
R-HSA-173745
Reaction Name: Factor D cleaves C3(H2O)-bound Factor B
See in Reactome
R-HSA-183122
(
R-HSA-173736
)
R-HSA-183122
Reaction Name: Factor D cleaves C3b-bound Factor B
See in Reactome
R-HSA-481007
(
R-HSA-114608
)
R-HSA-481007
Reaction Name: Exocytosis of platelet alpha granule contents
See in Reactome
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
|
MONDO:0013501 |
VCP |
P55072 |
3.6.4.6
|
R-HSA-3371511
R-HSA-9646399
R-HSA-110320
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5358346
R-HSA-9013407
R-HSA-532668
R-HSA-532668
Reactome Name: N-glycan trimming in the ER and Calnexin/Calreticulin cycle
See in Reactome
R-HSA-6798695
R-HSA-8876725
R-HSA-8866654
R-HSA-8866654
Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins
See in Reactome
R-HSA-5689877
|
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-382551
R-HSA-5358351
R-HSA-8953897
R-HSA-2262752
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-9612973
R-HSA-168249
R-HSA-9663891
R-HSA-392499
R-HSA-110313
R-HSA-110313
Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
See in Reactome
R-HSA-8852135
R-HSA-1632852
R-HSA-5688426
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-73894
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-162582
R-HSA-73893
|
Immune System
Transport of small molecules
Cellular responses to stimuli
Autophagy
Metabolism of proteins
DNA Repair
Signal Transduction
|
R-HSA-5324632
(
R-HSA-3371511
)
R-HSA-5324632
Reaction Name: Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates
See in Reactome
R-HSA-5362412
(
R-HSA-5358346
)
R-HSA-5362412
Reaction Name: SYVN1 ubiquitinates Hh C-terminal fragments
See in Reactome
R-HSA-5362441
(
R-HSA-5358346
)
R-HSA-5362441
Reaction Name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane
See in Reactome
R-HSA-5362459
(
R-HSA-5358346
)
R-HSA-5362459
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol
See in Reactome
R-HSA-5654985
(
R-HSA-110320
)
R-HSA-5654985
Reaction Name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH
See in Reactome
R-HSA-5654989
(
R-HSA-110320
)
R-HSA-5654989
Reaction Name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA
See in Reactome
R-HSA-5688834
(
R-HSA-5689877
)
R-HSA-6781953
(
R-HSA-5689896
)
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-8850594
(
R-HSA-532668
)
R-HSA-8850594
Reaction Name: Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins
See in Reactome
R-HSA-8866542
(
R-HSA-382556
)
R-HSA-8866542
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol
See in Reactome
R-HSA-8866546
(
R-HSA-382556
)
R-HSA-8866546
Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR
See in Reactome
R-HSA-8866551
(
R-HSA-382556
)
R-HSA-8866551
Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation
See in Reactome
R-HSA-8932276
(
R-HSA-8876725
)
R-HSA-8932276
Reaction Name: VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP
See in Reactome
R-HSA-8943080
(
R-HSA-8866654
)
R-HSA-8943080
Reaction Name: TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11
See in Reactome
R-HSA-8943083
(
R-HSA-8866654
)
R-HSA-8943083
Reaction Name: US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9646347
(
R-HSA-9646399
)
R-HSA-9646347
Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1
See in Reactome
R-HSA-9646354
(
R-HSA-9646399
)
R-HSA-9646354
Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex
See in Reactome
R-HSA-9755507
()
R-HSA-9755507
Reaction Name: UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex
See in Reactome
R-HSA-9758088
()
R-HSA-9758088
Reaction Name: UBXN7 binds VCP hexamer:UBF1:NPLOC4
See in Reactome
R-HSA-9758090
()
R-HSA-9758090
Reaction Name: Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation
See in Reactome
|
MONDO:0013571 |
CAT |
P04040 |
1.11.1.6
|
R-HSA-6798695
R-HSA-9615017
R-HSA-9615017
Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
See in Reactome
R-HSA-3299685
R-HSA-3299685
Reactome Name: Detoxification of Reactive Oxygen Species
See in Reactome
R-HSA-9033241
|
R-HSA-8953897
R-HSA-9609507
R-HSA-9614085
R-HSA-168256
R-HSA-168249
R-HSA-2262752
R-HSA-212436
R-HSA-9711123
R-HSA-9711123
Reactome Name: Cellular response to chemical stress
See in Reactome
R-HSA-74160
R-HSA-73857
|
Cellular responses to stimuli
Protein localization
Immune System
Gene expression (Transcription)
|
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-76031
(
R-HSA-3299685
)
R-HSA-9033233
(
R-HSA-9033241
)
R-HSA-9033233
(
R-HSA-9033241
)
R-HSA-9033233
Reaction Name: PEX5S,L binds cargo proteins containing PTS1
See in Reactome
R-HSA-9033235
(
R-HSA-9033241
)
R-HSA-9033235
(
R-HSA-9033241
)
R-HSA-9033235
Reaction Name: Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix
See in Reactome
R-HSA-9033236
(
R-HSA-9033241
)
R-HSA-9033236
(
R-HSA-9033241
)
R-HSA-9033236
Reaction Name: PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)
See in Reactome
R-HSA-9622738
(
R-HSA-9615017
)
R-HSA-9622738
Reaction Name: CAT gene expression is stimulated by FOXO3,FOXO6,(FOXO1)
See in Reactome
|
MONDO:0013743 |
PRKCD |
Q05655 |
2.7.11.13
2.7.10.2
|
R-HSA-111933
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-1489509
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-111465
R-HSA-111465
Reactome Name: Apoptotic cleavage of cellular proteins
See in Reactome
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-418597
R-HSA-877300
R-HSA-5607764
R-HSA-450520
R-HSA-450520
Reactome Name: HuR (ELAVL1) binds and stabilizes mRNA
See in Reactome
R-HSA-6798695
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-114508
|
R-HSA-111997
R-HSA-111996
R-HSA-418594
R-HSA-168256
R-HSA-194315
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-913531
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-388396
R-HSA-8953854
R-HSA-168249
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-112043
R-HSA-75153
R-HSA-195258
R-HSA-372790
R-HSA-112040
R-HSA-111885
R-HSA-5357801
R-HSA-416476
R-HSA-162582
R-HSA-1227986
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-109581
|
Immune System
Metabolism of RNA
Programmed Cell Death
Signal Transduction
Hemostasis
|
R-HSA-111966
(
R-HSA-111933;
R-HSA-1489509
)
R-HSA-111970
(
R-HSA-111933;
R-HSA-1489509
)
R-HSA-198314
(
R-HSA-1489509;
R-HSA-2029485
)
R-HSA-198314
Reaction Name: DAG stimulates protein kinase C-delta
See in Reactome
R-HSA-212552
(
R-HSA-111465
)
R-HSA-212552
Reaction Name: Caspase 3-mediated cleavage of PKC delta
See in Reactome
R-HSA-425861
(
R-HSA-114508
)
R-HSA-425861
Reaction Name: Activation of Protein Kinase C novel isoforms
See in Reactome
R-HSA-450533
(
R-HSA-450520
)
R-HSA-5218805
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218813
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218813
Reaction Name: DAG and Ca+2 bind to PKC and tether it to membrane
See in Reactome
R-HSA-5218821
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218823
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218823
Reaction Name: PKC phosphorylates sphingosine kinase 1
See in Reactome
R-HSA-5607734
(
R-HSA-5607764
)
R-HSA-5607734
Reaction Name: PKC-delta translocates to plasma membrane
See in Reactome
R-HSA-5607740
(
R-HSA-5607764
)
R-HSA-5607740
Reaction Name: PKC-delta phosphorylates CARD9
See in Reactome
R-HSA-5607746
(
R-HSA-5607764
)
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-751040
(
R-HSA-418597
)
R-HSA-8932284
()
R-HSA-8934446
(
R-HSA-1250196
)
R-HSA-8934446
Reaction Name: Activated PKC phosphorylates SHC1
See in Reactome
R-HSA-8982703
(
R-HSA-418597
)
R-HSA-8982709
(
R-HSA-418597
)
R-HSA-8982709
Reaction Name: G-alpha(z):PKC dissociates to give phosphorylated G alpha (z)
See in Reactome
R-HSA-909552
(
R-HSA-877300
)
R-HSA-909552
Reaction Name: Phosphorylation of STAT1 at Ser727
See in Reactome
R-HSA-9626817
(
R-HSA-5668599
)
|
MONDO:0013767 |
NRAS |
P01111 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-6798695
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-202733;
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392;
R-HSA-881907
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
|
MONDO:0013808 |
IDH1 |
O75874 |
1.1.1.42
|
R-HSA-6798695
R-HSA-9033241
R-HSA-389542
|
R-HSA-168256
R-HSA-9609507
R-HSA-8978934
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-168249
R-HSA-1430728
|
Immune System
Protein localization
Metabolism
|
R-HSA-389540
(
R-HSA-389542
)
R-HSA-389540
Reaction Name: isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
See in Reactome
R-HSA-389550
(
R-HSA-389542
)
R-HSA-389550
Reaction Name: isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
See in Reactome
R-HSA-6798745
(
R-HSA-6798695
)
R-HSA-6798745
Reaction Name: Exocytosis of tertiary granule lumen proteins
See in Reactome
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-9033233
(
R-HSA-9033241
)
R-HSA-9033233
(
R-HSA-9033241
)
R-HSA-9033233
Reaction Name: PEX5S,L binds cargo proteins containing PTS1
See in Reactome
R-HSA-9033235
(
R-HSA-9033241
)
R-HSA-9033235
(
R-HSA-9033241
)
R-HSA-9033235
Reaction Name: Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix
See in Reactome
R-HSA-9033236
(
R-HSA-9033241
)
R-HSA-9033236
(
R-HSA-9033241
)
R-HSA-9033236
Reaction Name: PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)
See in Reactome
R-HSA-9761844
()
R-HSA-9761844
Reaction Name: NFE2L2-dependent IDH1 gene expression
See in Reactome
|
MONDO:0013869 |
APRT |
P07741 |
2.4.2.7
|
R-HSA-6798695
R-HSA-74217
|
R-HSA-168249
R-HSA-1430728
R-HSA-15869
R-HSA-168256
R-HSA-8956321
|
Metabolism
Immune System
|
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-74213
(
R-HSA-74217
)
R-HSA-74213
Reaction Name: APRT catalyzes the conversion of adenine to AMP
See in Reactome
|
MONDO:0013941 |
IDH1 |
O75874 |
1.1.1.42
|
R-HSA-6798695
R-HSA-9033241
R-HSA-389542
|
R-HSA-168256
R-HSA-9609507
R-HSA-8978934
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-168249
R-HSA-1430728
|
Immune System
Protein localization
Metabolism
|
R-HSA-389540
(
R-HSA-389542
)
R-HSA-389540
Reaction Name: isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
See in Reactome
R-HSA-389550
(
R-HSA-389542
)
R-HSA-389550
Reaction Name: isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
See in Reactome
R-HSA-6798745
(
R-HSA-6798695
)
R-HSA-6798745
Reaction Name: Exocytosis of tertiary granule lumen proteins
See in Reactome
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-9033233
(
R-HSA-9033241
)
R-HSA-9033233
(
R-HSA-9033241
)
R-HSA-9033233
Reaction Name: PEX5S,L binds cargo proteins containing PTS1
See in Reactome
R-HSA-9033235
(
R-HSA-9033241
)
R-HSA-9033235
(
R-HSA-9033241
)
R-HSA-9033235
Reaction Name: Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix
See in Reactome
R-HSA-9033236
(
R-HSA-9033241
)
R-HSA-9033236
(
R-HSA-9033241
)
R-HSA-9033236
Reaction Name: PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)
See in Reactome
R-HSA-9761844
()
R-HSA-9761844
Reaction Name: NFE2L2-dependent IDH1 gene expression
See in Reactome
|
MONDO:0013968 |
PGM1 |
P36871 |
5.4.2.2
|
R-HSA-6798695
R-HSA-3322077
|
R-HSA-1430728
R-HSA-168249
R-HSA-168256
R-HSA-8982491
R-HSA-71387
|
Metabolism
Immune System
|
R-HSA-6798745
(
R-HSA-6798695
)
R-HSA-6798745
Reaction Name: Exocytosis of tertiary granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-9638125
(
R-HSA-3322077
)
R-HSA-9638125
Reaction Name: PGM1:Mg2+ isomerises G1P to G6P
See in Reactome
R-HSA-9638127
(
R-HSA-3322077
)
R-HSA-9638127
Reaction Name: PGM1:Mg2+ isomerises G6P to G1P
See in Reactome
|
MONDO:0014225 |
FTH1 |
P02794 |
1.16.3.1
|
R-HSA-3000480
R-HSA-3000480
Reactome Name: Scavenging by Class A Receptors
See in Reactome
R-HSA-6798695
R-HSA-432722
R-HSA-432722
Reactome Name: Golgi Associated Vesicle Biogenesis
See in Reactome
R-HSA-917937
|
R-HSA-168256
R-HSA-168249
R-HSA-382551
R-HSA-199991
R-HSA-199992
R-HSA-199992
Reactome Name: trans-Golgi Network Vesicle Budding
See in Reactome
R-HSA-2173782
R-HSA-2173782
Reactome Name: Binding and Uptake of Ligands by Scavenger Receptors
See in Reactome
R-HSA-5653656
|
Immune System
Transport of small molecules
Vesicle-mediated transport
|
R-HSA-1562626
(
R-HSA-917937
)
R-HSA-1562626
Reaction Name: Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)
See in Reactome
R-HSA-2187266
(
R-HSA-3000480
)
R-HSA-2299677
(
R-HSA-3000480
)
R-HSA-434362
(
R-HSA-432722
)
R-HSA-434362
Reaction Name: Recruitment Of Cytoplasmic Proteins To Vesicles
See in Reactome
R-HSA-6798745
(
R-HSA-6798695
)
R-HSA-6798745
Reaction Name: Exocytosis of tertiary granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
|
MONDO:0014234 |
ADAM10 |
O14672 |
3.4.24.81
|
R-HSA-381426
R-HSA-381426
Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
See in Reactome
R-HSA-9013507
R-HSA-9013507
Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus
See in Reactome
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-1474228
R-HSA-1474228
Reactome Name: Degradation of the extracellular matrix
See in Reactome
R-HSA-1442490
R-HSA-9013700
R-HSA-9013700
Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus
See in Reactome
R-HSA-977225
R-HSA-6798695
R-HSA-2122948
R-HSA-2122948
Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus
See in Reactome
R-HSA-177929
R-HSA-8957275
R-HSA-8957275
Reactome Name: Post-translational protein phosphorylation
See in Reactome
R-HSA-2979096
R-HSA-2979096
Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus
See in Reactome
|
R-HSA-1980143
R-HSA-9012852
R-HSA-1980145
R-HSA-168249
R-HSA-168256
R-HSA-9675108
R-HSA-392499
R-HSA-9013694
R-HSA-1474244
R-HSA-1474244
Reactome Name: Extracellular matrix organization
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-157118
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-422475
R-HSA-2682334
R-HSA-1266738
|
Immune System
Metabolism of proteins
Extracellular matrix organization
Signal Transduction
Developmental Biology
|
R-HSA-157629
(
R-HSA-2979096
)
R-HSA-157629
Reaction Name: NOTCH2-ligand complex is cleaved to produce NEXT2
See in Reactome
R-HSA-157632
(
R-HSA-2122948
)
R-HSA-157632
Reaction Name: Complex of NOTCH1 with its ligand is cleaved to produce NEXT1
See in Reactome
R-HSA-177946
(
R-HSA-177929
)
R-HSA-177946
Reaction Name: Pro-EGF is cleaved to form mature EGF
See in Reactome
R-HSA-2168960
(
R-HSA-1442490;
R-HSA-1474228
)
R-HSA-2168960
Reaction Name: Collagen type XVII ectodomain shedding
See in Reactome
R-HSA-3928660
(
R-HSA-3928665
)
R-HSA-4224014
(
R-HSA-1474228
)
R-HSA-4224014
Reaction Name: E-cadherin degradation by ADAM10, ADAM15
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-6799350
(
R-HSA-6798695
)
R-HSA-6799350
Reaction Name: Exocytosis of specific granule membrane proteins
See in Reactome
R-HSA-8952289
(
R-HSA-381426;
R-HSA-8957275
)
R-HSA-8952289
Reaction Name: FAM20C phosphorylates FAM20C substrates
See in Reactome
R-HSA-9010034
(
R-HSA-977225
)
R-HSA-9010034
Reaction Name: ADAM10:Zn2+:TSPANs cleaves APP(18-770)
See in Reactome
R-HSA-9010074
(
R-HSA-977225
)
R-HSA-9010074
Reaction Name: ADAM10:Zn2+:TSPANs translocates from ER lumen to plasma membrane
See in Reactome
R-HSA-9010113
(
R-HSA-977225
)
R-HSA-9013284
(
R-HSA-9013507
)
R-HSA-9013284
Reaction Name: NOTCH3-ligand complex is cleaved to produce NEXT3
See in Reactome
R-HSA-9604264
(
R-HSA-9013700
)
|
MONDO:0014253 |
PRKCD |
Q05655 |
2.7.11.13
2.7.10.2
|
R-HSA-111933
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-1489509
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-111465
R-HSA-111465
Reactome Name: Apoptotic cleavage of cellular proteins
See in Reactome
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-418597
R-HSA-877300
R-HSA-5607764
R-HSA-450520
R-HSA-450520
Reactome Name: HuR (ELAVL1) binds and stabilizes mRNA
See in Reactome
R-HSA-6798695
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-114508
|
R-HSA-111997
R-HSA-111996
R-HSA-418594
R-HSA-168256
R-HSA-194315
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-913531
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-388396
R-HSA-8953854
R-HSA-168249
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-112043
R-HSA-75153
R-HSA-195258
R-HSA-372790
R-HSA-112040
R-HSA-111885
R-HSA-5357801
R-HSA-416476
R-HSA-162582
R-HSA-1227986
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-109581
|
Immune System
Metabolism of RNA
Programmed Cell Death
Signal Transduction
Hemostasis
|
R-HSA-111966
(
R-HSA-111933;
R-HSA-1489509
)
R-HSA-111970
(
R-HSA-111933;
R-HSA-1489509
)
R-HSA-198314
(
R-HSA-1489509;
R-HSA-2029485
)
R-HSA-198314
Reaction Name: DAG stimulates protein kinase C-delta
See in Reactome
R-HSA-212552
(
R-HSA-111465
)
R-HSA-212552
Reaction Name: Caspase 3-mediated cleavage of PKC delta
See in Reactome
R-HSA-425861
(
R-HSA-114508
)
R-HSA-425861
Reaction Name: Activation of Protein Kinase C novel isoforms
See in Reactome
R-HSA-450533
(
R-HSA-450520
)
R-HSA-5218805
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218813
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218813
Reaction Name: DAG and Ca+2 bind to PKC and tether it to membrane
See in Reactome
R-HSA-5218821
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218823
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218823
Reaction Name: PKC phosphorylates sphingosine kinase 1
See in Reactome
R-HSA-5607734
(
R-HSA-5607764
)
R-HSA-5607734
Reaction Name: PKC-delta translocates to plasma membrane
See in Reactome
R-HSA-5607740
(
R-HSA-5607764
)
R-HSA-5607740
Reaction Name: PKC-delta phosphorylates CARD9
See in Reactome
R-HSA-5607746
(
R-HSA-5607764
)
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-751040
(
R-HSA-418597
)
R-HSA-8932284
()
R-HSA-8934446
(
R-HSA-1250196
)
R-HSA-8934446
Reaction Name: Activated PKC phosphorylates SHC1
See in Reactome
R-HSA-8982703
(
R-HSA-418597
)
R-HSA-8982709
(
R-HSA-418597
)
R-HSA-8982709
Reaction Name: G-alpha(z):PKC dissociates to give phosphorylated G alpha (z)
See in Reactome
R-HSA-909552
(
R-HSA-877300
)
R-HSA-909552
Reaction Name: Phosphorylation of STAT1 at Ser727
See in Reactome
R-HSA-9626817
(
R-HSA-5668599
)
|
MONDO:0014265 |
ADAM10 |
O14672 |
3.4.24.81
|
R-HSA-381426
R-HSA-381426
Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
See in Reactome
R-HSA-9013507
R-HSA-9013507
Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus
See in Reactome
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-1474228
R-HSA-1474228
Reactome Name: Degradation of the extracellular matrix
See in Reactome
R-HSA-1442490
R-HSA-9013700
R-HSA-9013700
Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus
See in Reactome
R-HSA-977225
R-HSA-6798695
R-HSA-2122948
R-HSA-2122948
Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus
See in Reactome
R-HSA-177929
R-HSA-8957275
R-HSA-8957275
Reactome Name: Post-translational protein phosphorylation
See in Reactome
R-HSA-2979096
R-HSA-2979096
Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus
See in Reactome
|
R-HSA-1980143
R-HSA-9012852
R-HSA-1980145
R-HSA-168249
R-HSA-168256
R-HSA-9675108
R-HSA-392499
R-HSA-9013694
R-HSA-1474244
R-HSA-1474244
Reactome Name: Extracellular matrix organization
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-157118
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-422475
R-HSA-2682334
R-HSA-1266738
|
Immune System
Metabolism of proteins
Extracellular matrix organization
Signal Transduction
Developmental Biology
|
R-HSA-157629
(
R-HSA-2979096
)
R-HSA-157629
Reaction Name: NOTCH2-ligand complex is cleaved to produce NEXT2
See in Reactome
R-HSA-157632
(
R-HSA-2122948
)
R-HSA-157632
Reaction Name: Complex of NOTCH1 with its ligand is cleaved to produce NEXT1
See in Reactome
R-HSA-177946
(
R-HSA-177929
)
R-HSA-177946
Reaction Name: Pro-EGF is cleaved to form mature EGF
See in Reactome
R-HSA-2168960
(
R-HSA-1442490;
R-HSA-1474228
)
R-HSA-2168960
Reaction Name: Collagen type XVII ectodomain shedding
See in Reactome
R-HSA-3928660
(
R-HSA-3928665
)
R-HSA-4224014
(
R-HSA-1474228
)
R-HSA-4224014
Reaction Name: E-cadherin degradation by ADAM10, ADAM15
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-6799350
(
R-HSA-6798695
)
R-HSA-6799350
Reaction Name: Exocytosis of specific granule membrane proteins
See in Reactome
R-HSA-8952289
(
R-HSA-381426;
R-HSA-8957275
)
R-HSA-8952289
Reaction Name: FAM20C phosphorylates FAM20C substrates
See in Reactome
R-HSA-9010034
(
R-HSA-977225
)
R-HSA-9010034
Reaction Name: ADAM10:Zn2+:TSPANs cleaves APP(18-770)
See in Reactome
R-HSA-9010074
(
R-HSA-977225
)
R-HSA-9010074
Reaction Name: ADAM10:Zn2+:TSPANs translocates from ER lumen to plasma membrane
See in Reactome
R-HSA-9010113
(
R-HSA-977225
)
R-HSA-9013284
(
R-HSA-9013507
)
R-HSA-9013284
Reaction Name: NOTCH3-ligand complex is cleaved to produce NEXT3
See in Reactome
R-HSA-9604264
(
R-HSA-9013700
)
|
MONDO:0014306 |
ADA2 |
Q9NZK5 |
3.5.4.4
|
R-HSA-6798695
R-HSA-5683826
|
R-HSA-168256
R-HSA-168249
R-HSA-392499
|
Immune System
Metabolism of proteins
|
R-HSA-5693346
(
R-HSA-5683826
)
R-HSA-5693346
Reaction Name: CECRI deaminates Ade-Rib to Ino
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
|
MONDO:0014375 |
DGAT1 |
O75907 |
2.3.1.20
2.3.1.76
|
R-HSA-6798695
R-HSA-1482883
R-HSA-1482883
Reactome Name: Acyl chain remodeling of DAG and TAG
See in Reactome
R-HSA-75109
|
R-HSA-168256
R-HSA-168249
R-HSA-1483257
R-HSA-1483206
R-HSA-1483206
Reactome Name: Glycerophospholipid biosynthesis
See in Reactome
R-HSA-1430728
R-HSA-8979227
R-HSA-556833
|
Immune System
Metabolism
|
R-HSA-1482889
(
R-HSA-1482883
)
R-HSA-1482889
Reaction Name: DAG is acylated to TAG by DGAT1/2
See in Reactome
R-HSA-6799350
(
R-HSA-6798695
)
R-HSA-6799350
Reaction Name: Exocytosis of specific granule membrane proteins
See in Reactome
R-HSA-75900
(
R-HSA-75109
)
R-HSA-75900
Reaction Name: 1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]
See in Reactome
|
MONDO:0014526 |
GYG1 |
P46976 |
2.4.1.186
|
R-HSA-6798695
R-HSA-3322077
R-HSA-70221
R-HSA-70221
Reactome Name: Glycogen breakdown (glycogenolysis)
See in Reactome
|
R-HSA-1430728
R-HSA-168249
R-HSA-168256
R-HSA-8982491
R-HSA-71387
|
Metabolism
Immune System
|
R-HSA-3322001
(
R-HSA-3322077
)
R-HSA-3322001
Reaction Name: GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1
See in Reactome
R-HSA-3322003
(
R-HSA-3322077
)
R-HSA-3322003
Reaction Name: Autoglucosylation of GYG1 complexed with GYS1-b
See in Reactome
R-HSA-3322005
(
R-HSA-3322077
)
R-HSA-3322005
Reaction Name: GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a
See in Reactome
R-HSA-3322025
(
R-HSA-3322077
)
R-HSA-3322025
Reaction Name: Autoglucosylation of GYG1 complexed with GYS1-a
See in Reactome
R-HSA-3322041
(
R-HSA-3322077
)
R-HSA-3322041
Reaction Name: Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1
See in Reactome
R-HSA-3322057
(
R-HSA-3322077
)
R-HSA-3322057
Reaction Name: GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b
See in Reactome
R-HSA-3781001
(
R-HSA-3322077
)
R-HSA-3781001
Reaction Name: EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG1 complex
See in Reactome
R-HSA-3781009
(
R-HSA-3322077
)
R-HSA-3781009
Reaction Name: NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1
See in Reactome
R-HSA-3781018
(
R-HSA-3322077
)
R-HSA-3781018
Reaction Name: EPM2A dimer dephosphorylates phosphoglycogen-GYG1
See in Reactome
R-HSA-3781023
(
R-HSA-3322077
)
R-HSA-3781023
Reaction Name: PPP1R3C binds to glycogen:GYG1:GYS1
See in Reactome
R-HSA-3781024
(
R-HSA-3322077
)
R-HSA-3781024
Reaction Name: GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1
See in Reactome
R-HSA-453358
(
R-HSA-70221
)
R-HSA-453358
Reaction Name: poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]
See in Reactome
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-71515
(
R-HSA-70221
)
R-HSA-71515
Reaction Name: glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]
See in Reactome
R-HSA-71552
(
R-HSA-70221
)
R-HSA-71552
Reaction Name: limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin
See in Reactome
R-HSA-71593
(
R-HSA-70221
)
R-HSA-71593
Reaction Name: ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose
See in Reactome
R-HSA-9036727
(
R-HSA-70221
)
R-HSA-9036727
Reaction Name: GAA hydrolyzes lysosomal glycogen
See in Reactome
|
MONDO:0014687 |
HGSNAT |
Q68CP4 |
2.3.1.78
|
R-HSA-6798695
R-HSA-2024096
|
R-HSA-71387
R-HSA-168256
R-HSA-168249
R-HSA-1638091
R-HSA-1638091
Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism
See in Reactome
R-HSA-1430728
R-HSA-1630316
|
Immune System
Metabolism
|
R-HSA-1678660
(
R-HSA-2024096
)
R-HSA-1678660
Reaction Name: HGSNAT oligomer acetylates Heparan sulfate chain(3)
See in Reactome
R-HSA-2090085
(
R-HSA-2024096
)
R-HSA-2090085
Reaction Name: HGSNAT oligomer acetylates Heparan chain(1)
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-6799350
(
R-HSA-6798695
)
R-HSA-6799350
Reaction Name: Exocytosis of specific granule membrane proteins
See in Reactome
|
MONDO:0014735 |
VCP |
P55072 |
3.6.4.6
|
R-HSA-3371511
R-HSA-9646399
R-HSA-110320
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5358346
R-HSA-9013407
R-HSA-532668
R-HSA-532668
Reactome Name: N-glycan trimming in the ER and Calnexin/Calreticulin cycle
See in Reactome
R-HSA-6798695
R-HSA-8876725
R-HSA-8866654
R-HSA-8866654
Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins
See in Reactome
R-HSA-5689877
|
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-382551
R-HSA-5358351
R-HSA-8953897
R-HSA-2262752
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-9612973
R-HSA-168249
R-HSA-9663891
R-HSA-392499
R-HSA-110313
R-HSA-110313
Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
See in Reactome
R-HSA-8852135
R-HSA-1632852
R-HSA-5688426
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-73894
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-162582
R-HSA-73893
|
Immune System
Transport of small molecules
Cellular responses to stimuli
Autophagy
Metabolism of proteins
DNA Repair
Signal Transduction
|
R-HSA-5324632
(
R-HSA-3371511
)
R-HSA-5324632
Reaction Name: Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates
See in Reactome
R-HSA-5362412
(
R-HSA-5358346
)
R-HSA-5362412
Reaction Name: SYVN1 ubiquitinates Hh C-terminal fragments
See in Reactome
R-HSA-5362441
(
R-HSA-5358346
)
R-HSA-5362441
Reaction Name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane
See in Reactome
R-HSA-5362459
(
R-HSA-5358346
)
R-HSA-5362459
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol
See in Reactome
R-HSA-5654985
(
R-HSA-110320
)
R-HSA-5654985
Reaction Name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH
See in Reactome
R-HSA-5654989
(
R-HSA-110320
)
R-HSA-5654989
Reaction Name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA
See in Reactome
R-HSA-5688834
(
R-HSA-5689877
)
R-HSA-6781953
(
R-HSA-5689896
)
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-8850594
(
R-HSA-532668
)
R-HSA-8850594
Reaction Name: Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins
See in Reactome
R-HSA-8866542
(
R-HSA-382556
)
R-HSA-8866542
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol
See in Reactome
R-HSA-8866546
(
R-HSA-382556
)
R-HSA-8866546
Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR
See in Reactome
R-HSA-8866551
(
R-HSA-382556
)
R-HSA-8866551
Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation
See in Reactome
R-HSA-8932276
(
R-HSA-8876725
)
R-HSA-8932276
Reaction Name: VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP
See in Reactome
R-HSA-8943080
(
R-HSA-8866654
)
R-HSA-8943080
Reaction Name: TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11
See in Reactome
R-HSA-8943083
(
R-HSA-8866654
)
R-HSA-8943083
Reaction Name: US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9646347
(
R-HSA-9646399
)
R-HSA-9646347
Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1
See in Reactome
R-HSA-9646354
(
R-HSA-9646399
)
R-HSA-9646354
Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex
See in Reactome
R-HSA-9755507
()
R-HSA-9755507
Reaction Name: UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex
See in Reactome
R-HSA-9758088
()
R-HSA-9758088
Reaction Name: UBXN7 binds VCP hexamer:UBF1:NPLOC4
See in Reactome
R-HSA-9758090
()
R-HSA-9758090
Reaction Name: Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation
See in Reactome
|
MONDO:0014827 |
CAPN1 |
P07384 |
3.4.22.52
|
R-HSA-6798695
R-HSA-1474228
R-HSA-1474228
Reactome Name: Degradation of the extracellular matrix
See in Reactome
R-HSA-6809371
R-HSA-6809371
Reactome Name: Formation of the cornified envelope
See in Reactome
|
R-HSA-168249
R-HSA-1474244
R-HSA-1474244
Reactome Name: Extracellular matrix organization
See in Reactome
R-HSA-168256
R-HSA-1266738
R-HSA-6805567
|
Extracellular matrix organization
Immune System
Developmental Biology
|
R-HSA-2534260
(
R-HSA-1474228
)
R-HSA-2534260
Reaction Name: E-cadherin degradation by caspase-3 and calpain-1
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-8848658
(
R-HSA-1474228
)
R-HSA-8848658
Reaction Name: CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins
See in Reactome
R-HSA-8934819
(
R-HSA-6809371
)
R-HSA-8934819
Reaction Name: Cytoplasmic proteases cleave Profilaggrin producing Filaggrin
See in Reactome
|
MONDO:0014866 |
MME |
P08473 |
3.4.24.11
|
R-HSA-6798695
R-HSA-2022377
R-HSA-2022377
Reactome Name: Metabolism of Angiotensinogen to Angiotensins
See in Reactome
|
R-HSA-168249
R-HSA-168256
R-HSA-2980736
R-HSA-392499
|
Immune System
Metabolism of proteins
|
R-HSA-2022368
(
R-HSA-2022377
)
R-HSA-2022368
Reaction Name: MME:Zn2+ hydrolyses AGT(34-42)
See in Reactome
R-HSA-2022396
(
R-HSA-2022377
)
R-HSA-2022396
Reaction Name: MME:Zn2+ hydrolyses AGT(34-43)
See in Reactome
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
|
MONDO:0014867 |
MME |
P08473 |
3.4.24.11
|
R-HSA-6798695
R-HSA-2022377
R-HSA-2022377
Reactome Name: Metabolism of Angiotensinogen to Angiotensins
See in Reactome
|
R-HSA-168249
R-HSA-168256
R-HSA-2980736
R-HSA-392499
|
Immune System
Metabolism of proteins
|
R-HSA-2022368
(
R-HSA-2022377
)
R-HSA-2022368
Reaction Name: MME:Zn2+ hydrolyses AGT(34-42)
See in Reactome
R-HSA-2022396
(
R-HSA-2022377
)
R-HSA-2022396
Reaction Name: MME:Zn2+ hydrolyses AGT(34-43)
See in Reactome
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
|
MONDO:0015168 |
ASAH1 |
Q13510 |
3.5.1.23
3.5.1.-
|
R-HSA-6798695
R-HSA-1660662
|
R-HSA-556833
R-HSA-168249
R-HSA-1430728
R-HSA-168256
R-HSA-428157
|
Metabolism
Immune System
|
R-HSA-1606602
(
R-HSA-1660662
)
R-HSA-1606602
Reaction Name: Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome)
See in Reactome
R-HSA-6798745
(
R-HSA-6798695
)
R-HSA-6798745
Reaction Name: Exocytosis of tertiary granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
|
MONDO:0015253 |
ADA2 |
Q9NZK5 |
3.5.4.4
|
R-HSA-6798695
R-HSA-5683826
|
R-HSA-168256
R-HSA-168249
R-HSA-392499
|
Immune System
Metabolism of proteins
|
R-HSA-5693346
(
R-HSA-5683826
)
R-HSA-5693346
Reaction Name: CECRI deaminates Ade-Rib to Ino
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
|
MONDO:0015517 |
PRKCD |
Q05655 |
2.7.11.13
2.7.10.2
|
R-HSA-111933
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-1489509
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-111465
R-HSA-111465
Reactome Name: Apoptotic cleavage of cellular proteins
See in Reactome
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-418597
R-HSA-877300
R-HSA-5607764
R-HSA-450520
R-HSA-450520
Reactome Name: HuR (ELAVL1) binds and stabilizes mRNA
See in Reactome
R-HSA-6798695
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-114508
|
R-HSA-111997
R-HSA-111996
R-HSA-418594
R-HSA-168256
R-HSA-194315
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-913531
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-388396
R-HSA-8953854
R-HSA-168249
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-112043
R-HSA-75153
R-HSA-195258
R-HSA-372790
R-HSA-112040
R-HSA-111885
R-HSA-5357801
R-HSA-416476
R-HSA-162582
R-HSA-1227986
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-109581
|
Immune System
Metabolism of RNA
Programmed Cell Death
Signal Transduction
Hemostasis
|
R-HSA-111966
(
R-HSA-111933;
R-HSA-1489509
)
R-HSA-111970
(
R-HSA-111933;
R-HSA-1489509
)
R-HSA-198314
(
R-HSA-1489509;
R-HSA-2029485
)
R-HSA-198314
Reaction Name: DAG stimulates protein kinase C-delta
See in Reactome
R-HSA-212552
(
R-HSA-111465
)
R-HSA-212552
Reaction Name: Caspase 3-mediated cleavage of PKC delta
See in Reactome
R-HSA-425861
(
R-HSA-114508
)
R-HSA-425861
Reaction Name: Activation of Protein Kinase C novel isoforms
See in Reactome
R-HSA-450533
(
R-HSA-450520
)
R-HSA-5218805
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218813
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218813
Reaction Name: DAG and Ca+2 bind to PKC and tether it to membrane
See in Reactome
R-HSA-5218821
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218823
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218823
Reaction Name: PKC phosphorylates sphingosine kinase 1
See in Reactome
R-HSA-5607734
(
R-HSA-5607764
)
R-HSA-5607734
Reaction Name: PKC-delta translocates to plasma membrane
See in Reactome
R-HSA-5607740
(
R-HSA-5607764
)
R-HSA-5607740
Reaction Name: PKC-delta phosphorylates CARD9
See in Reactome
R-HSA-5607746
(
R-HSA-5607764
)
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-751040
(
R-HSA-418597
)
R-HSA-8932284
()
R-HSA-8934446
(
R-HSA-1250196
)
R-HSA-8934446
Reaction Name: Activated PKC phosphorylates SHC1
See in Reactome
R-HSA-8982703
(
R-HSA-418597
)
R-HSA-8982709
(
R-HSA-418597
)
R-HSA-8982709
Reaction Name: G-alpha(z):PKC dissociates to give phosphorylated G alpha (z)
See in Reactome
R-HSA-909552
(
R-HSA-877300
)
R-HSA-909552
Reaction Name: Phosphorylation of STAT1 at Ser727
See in Reactome
R-HSA-9626817
(
R-HSA-5668599
)
|
MONDO:0015702 |
PTPRC |
P08575 |
3.1.3.48
|
R-HSA-6798695
R-HSA-416700
R-HSA-202427
R-HSA-202427
Reactome Name: Phosphorylation of CD3 and TCR zeta chains
See in Reactome
|
R-HSA-168249
R-HSA-168256
R-HSA-9675108
R-HSA-202403
R-HSA-373755
R-HSA-422475
R-HSA-1280218
R-HSA-1266738
|
Immune System
Developmental Biology
|
R-HSA-202214
(
R-HSA-202427
)
R-HSA-202214
Reaction Name: Dephosphorylation of Lck-pY505 by CD45
See in Reactome
R-HSA-202233
(
R-HSA-202427
)
R-HSA-373746
(
R-HSA-416700
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
|
MONDO:0016225 |
MAPK1 |
P28482 |
2.7.11.24
|
R-HSA-2559585
R-HSA-445144
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-111995
R-HSA-2559580
R-HSA-2559580
Reactome Name: Oxidative Stress Induced Senescence
See in Reactome
R-HSA-198753
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-8940973
R-HSA-8940973
Reactome Name: RUNX2 regulates osteoblast differentiation
See in Reactome
R-HSA-170968
R-HSA-437239
R-HSA-444257
R-HSA-6798695
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-1181150
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-982772
R-HSA-982772
Reactome Name: Growth hormone receptor signaling
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-2559582
R-HSA-2559582
Reactome Name: Senescence-Associated Secretory Phenotype (SASP)
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-5673001
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-2173796
R-HSA-2173796
Reactome Name: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
See in Reactome
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
R-HSA-1502540
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-450341
R-HSA-450341
Reactome Name: Activation of the AP-1 family of transcription factors
See in Reactome
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-74749
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-8939211
R-HSA-5674135
R-HSA-202670
R-HSA-879415
R-HSA-879415
Reactome Name: Advanced glycosylation endproduct receptor signaling
See in Reactome
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-162658
R-HSA-162658
Reactome Name: Golgi Cisternae Pericentriolar Stack Reorganization
See in Reactome
R-HSA-456926
R-HSA-456926
Reactome Name: Thrombin signalling through proteinase activated receptors (PARs)
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-112411
R-HSA-9627069
R-HSA-9627069
Reactome Name: Regulation of the apoptosome activity
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-111996
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-1640170
R-HSA-1266738
R-HSA-73857
R-HSA-212436
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-2262752
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-112316
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-373760
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-450294
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-416476
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-111471
R-HSA-111471
Reactome Name: Apoptotic factor-mediated response
See in Reactome
R-HSA-168256
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-450282
R-HSA-450282
Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases
See in Reactome
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-111461
R-HSA-111461
Reactome Name: Cytochrome c-mediated apoptotic response
See in Reactome
R-HSA-69278
R-HSA-198725
R-HSA-198725
Reactome Name: Nuclear Events (kinase and transcription factor activation)
See in Reactome
R-HSA-166166
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-168249
R-HSA-68886
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-187037
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-112043
R-HSA-112040
R-HSA-5654738
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-422475
R-HSA-68875
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-2559583
R-HSA-8941326
R-HSA-8941326
Reactome Name: RUNX2 regulates bone development
See in Reactome
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-5357801
R-HSA-74752
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-74160
R-HSA-168898
R-HSA-2173793
R-HSA-2173793
Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-8953897
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-111885
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-187687
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
R-HSA-449147
R-HSA-418594
R-HSA-194315
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-5684996
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-5654743
R-HSA-5654741
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-190236
R-HSA-388396
R-HSA-5654736
R-HSA-195258
R-HSA-1257604
R-HSA-372790
R-HSA-6807070
R-HSA-448424
R-HSA-109581
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-111458
R-HSA-109582
R-HSA-162582
|
Cell Cycle
Developmental Biology
Neuronal System
Immune System
Programmed Cell Death
Gene expression (Transcription)
Cellular responses to stimuli
Hemostasis
Signal Transduction
|
R-HSA-109822
(
R-HSA-74749
)
R-HSA-109822
Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1
See in Reactome
R-HSA-109823
(
R-HSA-74749
)
R-HSA-109823
Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2
See in Reactome
R-HSA-109858
(
R-HSA-112409;
R-HSA-112411
)
R-HSA-109862
(
R-HSA-112409;
R-HSA-112411;
R-HSA-445144
)
R-HSA-109864
(
R-HSA-112409;
R-HSA-112411
)
R-HSA-109864
Reaction Name: Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2
See in Reactome
R-HSA-111898
(
R-HSA-111995
)
R-HSA-111898
Reaction Name: Phosphorylation of cPLA2 by ERK-2
See in Reactome
R-HSA-1168459
(
R-HSA-982772
)
R-HSA-1295634
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-168053
(
R-HSA-166058;
R-HSA-168188;
R-HSA-450341
)
R-HSA-168053
Reaction Name: Phosphorylated MAPKs phosphorylate ATF-2
See in Reactome
R-HSA-173488
(
R-HSA-1181150;
R-HSA-1502540;
R-HSA-2173796
)
R-HSA-173488
Reaction Name: The SMAD2/3:SMAD4 complex transfers to the nucleus
See in Reactome
R-HSA-198731
(
R-HSA-166058;
R-HSA-168188;
R-HSA-198753;
R-HSA-8939211;
R-HSA-9634638
)
R-HSA-198746
(
R-HSA-166058;
R-HSA-168188;
R-HSA-198753;
R-HSA-2559582;
R-HSA-881907
)
R-HSA-198756
(
R-HSA-166058;
R-HSA-168188;
R-HSA-198753;
R-HSA-375165
)
R-HSA-199959
(
R-HSA-166058;
R-HSA-168188;
R-HSA-198753;
R-HSA-202670
)
R-HSA-199959
Reaction Name: ERKs are inactivated by protein phosphatase 2A
See in Reactome
R-HSA-2029469
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029469
Reaction Name: p-ERK phosphorylates WAVEs and ABI
See in Reactome
R-HSA-203797
(
R-HSA-166058;
R-HSA-168188;
R-HSA-198753;
R-HSA-202670
)
R-HSA-203797
Reaction Name: ERKs are inactivated by dual-specific phosphatases (DUSPs)
See in Reactome
R-HSA-2422927
(
R-HSA-162658
)
R-HSA-2422927
Reaction Name: MAPK3-3 or MAPK1 phosphorylate GORASP2
See in Reactome
R-HSA-3132737
(
R-HSA-2559585
)
R-HSA-3132737
Reaction Name: MAPKs phosphorylate ETS1 and ETS2
See in Reactome
R-HSA-3209160
(
R-HSA-2559585
)
R-HSA-3209160
Reaction Name: Activated ERKs phosphorylate ERF
See in Reactome
R-HSA-3209177
(
R-HSA-2559585
)
R-HSA-3223236
(
R-HSA-2559580
)
R-HSA-3223236
Reaction Name: RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS)
See in Reactome
R-HSA-3371531
(
R-HSA-3371453
)
R-HSA-3371531
Reaction Name: Constitutive phosphorylation by pERK1/2
See in Reactome
R-HSA-3857329
(
R-HSA-2559582
)
R-HSA-3857329
Reaction Name: MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB
See in Reactome
R-HSA-418158
(
R-HSA-456926
)
R-HSA-418158
Reaction Name: SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1)
See in Reactome
R-HSA-418163
(
R-HSA-456926
)
R-HSA-418163
Reaction Name: Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)
See in Reactome
R-HSA-418170
(
R-HSA-456926
)
R-HSA-418176
(
R-HSA-456926
)
R-HSA-418200
(
R-HSA-456926
)
R-HSA-418200
Reaction Name: SRC-1 bound to ARRB2 is not activated
See in Reactome
R-HSA-445079
(
R-HSA-437239
)
R-HSA-450325
(
R-HSA-166058;
R-HSA-168188;
R-HSA-2559580;
R-HSA-2871796;
R-HSA-450341
)
R-HSA-450325
Reaction Name: c-FOS activation by phospho ERK1/2
See in Reactome
R-HSA-5654560
(
R-HSA-5654726
)
R-HSA-5654560
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2.
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654565
(
R-HSA-5654732
)
R-HSA-5654565
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2.
See in Reactome
R-HSA-5654566
(
R-HSA-5654733
)
R-HSA-5654566
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2.
See in Reactome
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674366
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674366
Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs
See in Reactome
R-HSA-5674373
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674373
Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane
See in Reactome
R-HSA-5674385
(
R-HSA-112409;
R-HSA-170968;
R-HSA-5673001
)
R-HSA-5674387
(
R-HSA-112409;
R-HSA-5673001
)
R-HSA-5674387
Reaction Name: Phosphorylated MAPKs translocate into the nucleus
See in Reactome
R-HSA-5674496
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5674496
Reaction Name: Activated MAPKs phosphorylate MAP2K1
See in Reactome
R-HSA-5675194
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675194
Reaction Name: Activated MAPK phosphorylates RAF1
See in Reactome
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675206
(
R-HSA-112409;
R-HSA-5673001
)
R-HSA-5675206
Reaction Name: PEA15 binds MAPK monomers and dimers
See in Reactome
R-HSA-5675373
(
R-HSA-112409;
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675373
Reaction Name: Nuclear DUSPs dephosphorylate MAPKs
See in Reactome
R-HSA-5675376
(
R-HSA-112409;
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675376
Reaction Name: Cytosolic DUSPs dephosphorylate MAPKs
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-6811454
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-6811472
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-6811472
Reaction Name: IER3 recruits MAPKs to PP2A-B56-beta,gamma
See in Reactome
R-HSA-879362
(
R-HSA-879415
)
R-HSA-8944047
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944047
Reaction Name: JUN binds the PTEN gene promoter
See in Reactome
R-HSA-9009208
(
R-HSA-8940973
)
R-HSA-9009208
Reaction Name: Activated ERKs phosphorylate RUNX2
See in Reactome
R-HSA-9032751
(
R-HSA-8939211
)
R-HSA-9032751
Reaction Name: Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610166
(
R-HSA-170968
)
R-HSA-9610166
Reaction Name: p-T,Y MAPK dimers translocate to nucleus
See in Reactome
R-HSA-9619843
(
R-HSA-444257
)
R-HSA-9626832
(
R-HSA-5668599
)
R-HSA-9626832
Reaction Name: MAPK1 or MAPK3 phosphorylates NCF1 at Ser345
See in Reactome
R-HSA-9627089
(
R-HSA-9627069
)
R-HSA-9627089
Reaction Name: CASP9 is phosphorylated at T125
See in Reactome
R-HSA-9632873
(
R-HSA-8939211;
R-HSA-9634638
)
R-HSA-9632873
Reaction Name: p-S10 CDKN1B translocates to the cytosol
See in Reactome
R-HSA-9632910
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9635739
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-9635739
Reaction Name: PTPN7 dephosphorylates p-T,Y-MAPKs
See in Reactome
R-HSA-9635743
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
|
MONDO:0016306 |
NPC2 |
P61916 |
-
|
R-HSA-6798695
R-HSA-8964038
|
R-HSA-168249
R-HSA-168256
R-HSA-174824
R-HSA-174824
Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance
See in Reactome
R-HSA-8964043
R-HSA-382551
|
Immune System
Transport of small molecules
|
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-8876472
(
R-HSA-8964038
)
R-HSA-8876484
(
R-HSA-8964038
)
|
MONDO:0016307 |
NPC2 |
P61916 |
-
|
R-HSA-6798695
R-HSA-8964038
|
R-HSA-168249
R-HSA-168256
R-HSA-174824
R-HSA-174824
Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance
See in Reactome
R-HSA-8964043
R-HSA-382551
|
Immune System
Transport of small molecules
|
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-8876472
(
R-HSA-8964038
)
R-HSA-8876484
(
R-HSA-8964038
)
|
MONDO:0016308 |
NPC2 |
P61916 |
-
|
R-HSA-6798695
R-HSA-8964038
|
R-HSA-168249
R-HSA-168256
R-HSA-174824
R-HSA-174824
Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance
See in Reactome
R-HSA-8964043
R-HSA-382551
|
Immune System
Transport of small molecules
|
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-8876472
(
R-HSA-8964038
)
R-HSA-8876484
(
R-HSA-8964038
)
|
MONDO:0016309 |
NPC2 |
P61916 |
-
|
R-HSA-6798695
R-HSA-8964038
|
R-HSA-168249
R-HSA-168256
R-HSA-174824
R-HSA-174824
Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance
See in Reactome
R-HSA-8964043
R-HSA-382551
|
Immune System
Transport of small molecules
|
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-8876472
(
R-HSA-8964038
)
R-HSA-8876484
(
R-HSA-8964038
)
|
MONDO:0016310 |
NPC2 |
P61916 |
-
|
R-HSA-6798695
R-HSA-8964038
|
R-HSA-168249
R-HSA-168256
R-HSA-174824
R-HSA-174824
Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance
See in Reactome
R-HSA-8964043
R-HSA-382551
|
Immune System
Transport of small molecules
|
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-8876472
(
R-HSA-8964038
)
R-HSA-8876484
(
R-HSA-8964038
)
|
MONDO:0016392 |
DDX3X |
O00571 |
3.6.4.13
|
R-HSA-6798695
|
R-HSA-168249
R-HSA-168256
|
Immune System
|
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
|
MONDO:0017171 |
ARSB |
P15848 |
3.1.6.12
|
R-HSA-6798695
R-HSA-2024101
R-HSA-1660662
R-HSA-1663150
R-HSA-1663150
Reactome Name: The activation of arylsulfatases
See in Reactome
|
R-HSA-71387
R-HSA-1793185
R-HSA-1793185
Reactome Name: Chondroitin sulfate/dermatan sulfate metabolism
See in Reactome
R-HSA-168256
R-HSA-163841
R-HSA-163841
Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-428157
R-HSA-1430728
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-556833
R-HSA-1630316
|
Immune System
Metabolism of proteins
Metabolism
|
R-HSA-1606789
(
R-HSA-2024101
)
R-HSA-1614362
(
R-HSA-1660662;
R-HSA-1663150
)
R-HSA-1614362
Reaction Name: SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases
See in Reactome
R-HSA-1793207
(
R-HSA-2024101
)
R-HSA-1793207
Reaction Name: ARSB hydrolyses C4S/C6S chains
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
|
MONDO:0017172 |
ARSB |
P15848 |
3.1.6.12
|
R-HSA-6798695
R-HSA-2024101
R-HSA-1660662
R-HSA-1663150
R-HSA-1663150
Reactome Name: The activation of arylsulfatases
See in Reactome
|
R-HSA-71387
R-HSA-1793185
R-HSA-1793185
Reactome Name: Chondroitin sulfate/dermatan sulfate metabolism
See in Reactome
R-HSA-168256
R-HSA-163841
R-HSA-163841
Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-428157
R-HSA-1430728
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-556833
R-HSA-1630316
|
Immune System
Metabolism of proteins
Metabolism
|
R-HSA-1606789
(
R-HSA-2024101
)
R-HSA-1614362
(
R-HSA-1660662;
R-HSA-1663150
)
R-HSA-1614362
Reaction Name: SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases
See in Reactome
R-HSA-1793207
(
R-HSA-2024101
)
R-HSA-1793207
Reaction Name: ARSB hydrolyses C4S/C6S chains
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
|
MONDO:0017694 |
GAA |
P10253 |
3.2.1.20
|
R-HSA-6798695
R-HSA-70221
R-HSA-70221
Reactome Name: Glycogen breakdown (glycogenolysis)
See in Reactome
|
R-HSA-1430728
R-HSA-168249
R-HSA-168256
R-HSA-8982491
R-HSA-71387
|
Metabolism
Immune System
|
R-HSA-6798739
(
R-HSA-6798695
)
R-HSA-6798739
Reaction Name: Exocytosis of azurophil granule membrane proteins
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-9036727
(
R-HSA-70221
)
R-HSA-9036727
Reaction Name: GAA hydrolyzes lysosomal glycogen
See in Reactome
|
MONDO:0017721 |
HEXB |
P07686 |
3.2.1.52
|
R-HSA-2022857
R-HSA-2024101
R-HSA-1660662
R-HSA-6798695
R-HSA-2160916
R-HSA-2160916
Reactome Name: Hyaluronan uptake and degradation
See in Reactome
|
R-HSA-71387
R-HSA-1638074
R-HSA-1638074
Reactome Name: Keratan sulfate/keratin metabolism
See in Reactome
R-HSA-1793185
R-HSA-1793185
Reactome Name: Chondroitin sulfate/dermatan sulfate metabolism
See in Reactome
R-HSA-168256
R-HSA-168249
R-HSA-2142845
R-HSA-1430728
R-HSA-556833
R-HSA-1630316
R-HSA-428157
|
Immune System
Metabolism
|
R-HSA-1605595
(
R-HSA-1660662
)
R-HSA-1605595
Reaction Name: Hexosaminidase A cleaves GalNAc from GM2 to form GM3
See in Reactome
R-HSA-1605632
(
R-HSA-1660662
)
R-HSA-1605632
Reaction Name: Both hexosaminidase A and B can cleave GalNAc from globoside
See in Reactome
R-HSA-1638053
(
R-HSA-2022857
)
R-HSA-1638053
Reaction Name: HEXA cleaves the terminal GalNAc from keratan sulfate
See in Reactome
R-HSA-2105001
(
R-HSA-2024101
)
R-HSA-2105001
Reaction Name: HEXA cleaves the terminal GalNAc from DS
See in Reactome
R-HSA-2162225
(
R-HSA-2160916
)
R-HSA-2162225
Reaction Name: HEXA cleaves the terminal GalNAc from small HA fragments
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-9638075
(
R-HSA-2024101
)
R-HSA-9638075
Reaction Name: HEXB cleaves the terminal GalNAc from DS
See in Reactome
R-HSA-9638076
(
R-HSA-2160916
)
R-HSA-9638076
Reaction Name: HEXB cleaves the terminal GalNAc from small HA fragments
See in Reactome
R-HSA-9638078
(
R-HSA-2022857
)
R-HSA-9638078
Reaction Name: HEXB cleaves the terminal GalNAc from keratan sulfate
See in Reactome
|
MONDO:0017722 |
HEXB |
P07686 |
3.2.1.52
|
R-HSA-2022857
R-HSA-2024101
R-HSA-1660662
R-HSA-6798695
R-HSA-2160916
R-HSA-2160916
Reactome Name: Hyaluronan uptake and degradation
See in Reactome
|
R-HSA-71387
R-HSA-1638074
R-HSA-1638074
Reactome Name: Keratan sulfate/keratin metabolism
See in Reactome
R-HSA-1793185
R-HSA-1793185
Reactome Name: Chondroitin sulfate/dermatan sulfate metabolism
See in Reactome
R-HSA-168256
R-HSA-168249
R-HSA-2142845
R-HSA-1430728
R-HSA-556833
R-HSA-1630316
R-HSA-428157
|
Immune System
Metabolism
|
R-HSA-1605595
(
R-HSA-1660662
)
R-HSA-1605595
Reaction Name: Hexosaminidase A cleaves GalNAc from GM2 to form GM3
See in Reactome
R-HSA-1605632
(
R-HSA-1660662
)
R-HSA-1605632
Reaction Name: Both hexosaminidase A and B can cleave GalNAc from globoside
See in Reactome
R-HSA-1638053
(
R-HSA-2022857
)
R-HSA-1638053
Reaction Name: HEXA cleaves the terminal GalNAc from keratan sulfate
See in Reactome
R-HSA-2105001
(
R-HSA-2024101
)
R-HSA-2105001
Reaction Name: HEXA cleaves the terminal GalNAc from DS
See in Reactome
R-HSA-2162225
(
R-HSA-2160916
)
R-HSA-2162225
Reaction Name: HEXA cleaves the terminal GalNAc from small HA fragments
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-9638075
(
R-HSA-2024101
)
R-HSA-9638075
Reaction Name: HEXB cleaves the terminal GalNAc from DS
See in Reactome
R-HSA-9638076
(
R-HSA-2160916
)
R-HSA-9638076
Reaction Name: HEXB cleaves the terminal GalNAc from small HA fragments
See in Reactome
R-HSA-9638078
(
R-HSA-2022857
)
R-HSA-9638078
Reaction Name: HEXB cleaves the terminal GalNAc from keratan sulfate
See in Reactome
|
MONDO:0017723 |
HEXB |
P07686 |
3.2.1.52
|
R-HSA-2022857
R-HSA-2024101
R-HSA-1660662
R-HSA-6798695
R-HSA-2160916
R-HSA-2160916
Reactome Name: Hyaluronan uptake and degradation
See in Reactome
|
R-HSA-71387
R-HSA-1638074
R-HSA-1638074
Reactome Name: Keratan sulfate/keratin metabolism
See in Reactome
R-HSA-1793185
R-HSA-1793185
Reactome Name: Chondroitin sulfate/dermatan sulfate metabolism
See in Reactome
R-HSA-168256
R-HSA-168249
R-HSA-2142845
R-HSA-1430728
R-HSA-556833
R-HSA-1630316
R-HSA-428157
|
Immune System
Metabolism
|
R-HSA-1605595
(
R-HSA-1660662
)
R-HSA-1605595
Reaction Name: Hexosaminidase A cleaves GalNAc from GM2 to form GM3
See in Reactome
R-HSA-1605632
(
R-HSA-1660662
)
R-HSA-1605632
Reaction Name: Both hexosaminidase A and B can cleave GalNAc from globoside
See in Reactome
R-HSA-1638053
(
R-HSA-2022857
)
R-HSA-1638053
Reaction Name: HEXA cleaves the terminal GalNAc from keratan sulfate
See in Reactome
R-HSA-2105001
(
R-HSA-2024101
)
R-HSA-2105001
Reaction Name: HEXA cleaves the terminal GalNAc from DS
See in Reactome
R-HSA-2162225
(
R-HSA-2160916
)
R-HSA-2162225
Reaction Name: HEXA cleaves the terminal GalNAc from small HA fragments
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-9638075
(
R-HSA-2024101
)
R-HSA-9638075
Reaction Name: HEXB cleaves the terminal GalNAc from DS
See in Reactome
R-HSA-9638076
(
R-HSA-2160916
)
R-HSA-9638076
Reaction Name: HEXB cleaves the terminal GalNAc from small HA fragments
See in Reactome
R-HSA-9638078
(
R-HSA-2022857
)
R-HSA-9638078
Reaction Name: HEXB cleaves the terminal GalNAc from keratan sulfate
See in Reactome
|
MONDO:0017729 |
ARSA |
P15289 |
3.1.6.8
|
R-HSA-6798695
R-HSA-1660662
R-HSA-1663150
R-HSA-1663150
Reactome Name: The activation of arylsulfatases
See in Reactome
|
R-HSA-168256
R-HSA-163841
R-HSA-163841
Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-428157
R-HSA-1430728
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
|
Immune System
Metabolism of proteins
Metabolism
|
R-HSA-1606807
(
R-HSA-1660662
)
R-HSA-1606807
Reaction Name: Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside
See in Reactome
R-HSA-1614362
(
R-HSA-1660662;
R-HSA-1663150
)
R-HSA-1614362
Reaction Name: SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases
See in Reactome
R-HSA-2248891
(
R-HSA-1660662
)
R-HSA-2248891
Reaction Name: Active ARSA translocates to the lysosome
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
|
MONDO:0017730 |
ARSA |
P15289 |
3.1.6.8
|
R-HSA-6798695
R-HSA-1660662
R-HSA-1663150
R-HSA-1663150
Reactome Name: The activation of arylsulfatases
See in Reactome
|
R-HSA-168256
R-HSA-163841
R-HSA-163841
Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-428157
R-HSA-1430728
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
|
Immune System
Metabolism of proteins
Metabolism
|
R-HSA-1606807
(
R-HSA-1660662
)
R-HSA-1606807
Reaction Name: Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside
See in Reactome
R-HSA-1614362
(
R-HSA-1660662;
R-HSA-1663150
)
R-HSA-1614362
Reaction Name: SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases
See in Reactome
R-HSA-2248891
(
R-HSA-1660662
)
R-HSA-2248891
Reaction Name: Active ARSA translocates to the lysosome
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
|
MONDO:0017732 |
MAN2B1 |
O00754 |
3.2.1.24
|
R-HSA-6798695
R-HSA-8853383
R-HSA-8853383
Reactome Name: Lysosomal oligosaccharide catabolism
See in Reactome
|
R-HSA-168249
R-HSA-1430728
R-HSA-168256
R-HSA-71387
|
Metabolism
Immune System
|
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-8853686
(
R-HSA-8853383
)
R-HSA-8853686
Reaction Name: MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3
See in Reactome
|
MONDO:0017733 |
MAN2B1 |
O00754 |
3.2.1.24
|
R-HSA-6798695
R-HSA-8853383
R-HSA-8853383
Reactome Name: Lysosomal oligosaccharide catabolism
See in Reactome
|
R-HSA-168249
R-HSA-1430728
R-HSA-168256
R-HSA-71387
|
Metabolism
Immune System
|
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-8853686
(
R-HSA-8853383
)
R-HSA-8853686
Reaction Name: MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3
See in Reactome
|
MONDO:0018005 |
VCP |
P55072 |
3.6.4.6
|
R-HSA-3371511
R-HSA-9646399
R-HSA-110320
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5358346
R-HSA-9013407
R-HSA-532668
R-HSA-532668
Reactome Name: N-glycan trimming in the ER and Calnexin/Calreticulin cycle
See in Reactome
R-HSA-6798695
R-HSA-8876725
R-HSA-8866654
R-HSA-8866654
Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins
See in Reactome
R-HSA-5689877
|
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-382551
R-HSA-5358351
R-HSA-8953897
R-HSA-2262752
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-9612973
R-HSA-168249
R-HSA-9663891
R-HSA-392499
R-HSA-110313
R-HSA-110313
Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
See in Reactome
R-HSA-8852135
R-HSA-1632852
R-HSA-5688426
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-73894
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-162582
R-HSA-73893
|
Immune System
Transport of small molecules
Cellular responses to stimuli
Autophagy
Metabolism of proteins
DNA Repair
Signal Transduction
|
R-HSA-5324632
(
R-HSA-3371511
)
R-HSA-5324632
Reaction Name: Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates
See in Reactome
R-HSA-5362412
(
R-HSA-5358346
)
R-HSA-5362412
Reaction Name: SYVN1 ubiquitinates Hh C-terminal fragments
See in Reactome
R-HSA-5362441
(
R-HSA-5358346
)
R-HSA-5362441
Reaction Name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane
See in Reactome
R-HSA-5362459
(
R-HSA-5358346
)
R-HSA-5362459
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol
See in Reactome
R-HSA-5654985
(
R-HSA-110320
)
R-HSA-5654985
Reaction Name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH
See in Reactome
R-HSA-5654989
(
R-HSA-110320
)
R-HSA-5654989
Reaction Name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA
See in Reactome
R-HSA-5688834
(
R-HSA-5689877
)
R-HSA-6781953
(
R-HSA-5689896
)
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-8850594
(
R-HSA-532668
)
R-HSA-8850594
Reaction Name: Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins
See in Reactome
R-HSA-8866542
(
R-HSA-382556
)
R-HSA-8866542
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol
See in Reactome
R-HSA-8866546
(
R-HSA-382556
)
R-HSA-8866546
Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR
See in Reactome
R-HSA-8866551
(
R-HSA-382556
)
R-HSA-8866551
Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation
See in Reactome
R-HSA-8932276
(
R-HSA-8876725
)
R-HSA-8932276
Reaction Name: VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP
See in Reactome
R-HSA-8943080
(
R-HSA-8866654
)
R-HSA-8943080
Reaction Name: TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11
See in Reactome
R-HSA-8943083
(
R-HSA-8866654
)
R-HSA-8943083
Reaction Name: US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9646347
(
R-HSA-9646399
)
R-HSA-9646347
Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1
See in Reactome
R-HSA-9646354
(
R-HSA-9646399
)
R-HSA-9646354
Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex
See in Reactome
R-HSA-9755507
()
R-HSA-9755507
Reaction Name: UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex
See in Reactome
R-HSA-9758088
()
R-HSA-9758088
Reaction Name: UBXN7 binds VCP hexamer:UBF1:NPLOC4
See in Reactome
R-HSA-9758090
()
R-HSA-9758090
Reaction Name: Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation
See in Reactome
|
MONDO:0018006 |
VCP |
P55072 |
3.6.4.6
|
R-HSA-3371511
R-HSA-9646399
R-HSA-110320
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5358346
R-HSA-9013407
R-HSA-532668
R-HSA-532668
Reactome Name: N-glycan trimming in the ER and Calnexin/Calreticulin cycle
See in Reactome
R-HSA-6798695
R-HSA-8876725
R-HSA-8866654
R-HSA-8866654
Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins
See in Reactome
R-HSA-5689877
|
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-382551
R-HSA-5358351
R-HSA-8953897
R-HSA-2262752
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-9612973
R-HSA-168249
R-HSA-9663891
R-HSA-392499
R-HSA-110313
R-HSA-110313
Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
See in Reactome
R-HSA-8852135
R-HSA-1632852
R-HSA-5688426
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-73894
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-162582
R-HSA-73893
|
Immune System
Transport of small molecules
Cellular responses to stimuli
Autophagy
Metabolism of proteins
DNA Repair
Signal Transduction
|
R-HSA-5324632
(
R-HSA-3371511
)
R-HSA-5324632
Reaction Name: Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates
See in Reactome
R-HSA-5362412
(
R-HSA-5358346
)
R-HSA-5362412
Reaction Name: SYVN1 ubiquitinates Hh C-terminal fragments
See in Reactome
R-HSA-5362441
(
R-HSA-5358346
)
R-HSA-5362441
Reaction Name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane
See in Reactome
R-HSA-5362459
(
R-HSA-5358346
)
R-HSA-5362459
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol
See in Reactome
R-HSA-5654985
(
R-HSA-110320
)
R-HSA-5654985
Reaction Name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH
See in Reactome
R-HSA-5654989
(
R-HSA-110320
)
R-HSA-5654989
Reaction Name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA
See in Reactome
R-HSA-5688834
(
R-HSA-5689877
)
R-HSA-6781953
(
R-HSA-5689896
)
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-8850594
(
R-HSA-532668
)
R-HSA-8850594
Reaction Name: Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins
See in Reactome
R-HSA-8866542
(
R-HSA-382556
)
R-HSA-8866542
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol
See in Reactome
R-HSA-8866546
(
R-HSA-382556
)
R-HSA-8866546
Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR
See in Reactome
R-HSA-8866551
(
R-HSA-382556
)
R-HSA-8866551
Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation
See in Reactome
R-HSA-8932276
(
R-HSA-8876725
)
R-HSA-8932276
Reaction Name: VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP
See in Reactome
R-HSA-8943080
(
R-HSA-8866654
)
R-HSA-8943080
Reaction Name: TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11
See in Reactome
R-HSA-8943083
(
R-HSA-8866654
)
R-HSA-8943083
Reaction Name: US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9646347
(
R-HSA-9646399
)
R-HSA-9646347
Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1
See in Reactome
R-HSA-9646354
(
R-HSA-9646399
)
R-HSA-9646354
Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex
See in Reactome
R-HSA-9755507
()
R-HSA-9755507
Reaction Name: UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex
See in Reactome
R-HSA-9758088
()
R-HSA-9758088
Reaction Name: UBXN7 binds VCP hexamer:UBF1:NPLOC4
See in Reactome
R-HSA-9758090
()
R-HSA-9758090
Reaction Name: Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation
See in Reactome
|
MONDO:0018485 |
GAA |
P10253 |
3.2.1.20
|
R-HSA-6798695
R-HSA-70221
R-HSA-70221
Reactome Name: Glycogen breakdown (glycogenolysis)
See in Reactome
|
R-HSA-1430728
R-HSA-168249
R-HSA-168256
R-HSA-8982491
R-HSA-71387
|
Metabolism
Immune System
|
R-HSA-6798739
(
R-HSA-6798695
)
R-HSA-6798739
Reaction Name: Exocytosis of azurophil granule membrane proteins
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-9036727
(
R-HSA-70221
)
R-HSA-9036727
Reaction Name: GAA hydrolyzes lysosomal glycogen
See in Reactome
|
MONDO:0018709 |
DDX3X |
O00571 |
3.6.4.13
|
R-HSA-6798695
|
R-HSA-168249
R-HSA-168256
|
Immune System
|
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
|
MONDO:0018908 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0019068 |
MME |
P08473 |
3.4.24.11
|
R-HSA-6798695
R-HSA-2022377
R-HSA-2022377
Reactome Name: Metabolism of Angiotensinogen to Angiotensins
See in Reactome
|
R-HSA-168249
R-HSA-168256
R-HSA-2980736
R-HSA-392499
|
Immune System
Metabolism of proteins
|
R-HSA-2022368
(
R-HSA-2022377
)
R-HSA-2022368
Reaction Name: MME:Zn2+ hydrolyses AGT(34-42)
See in Reactome
R-HSA-2022396
(
R-HSA-2022377
)
R-HSA-2022396
Reaction Name: MME:Zn2+ hydrolyses AGT(34-43)
See in Reactome
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
|
MONDO:0019086 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0019346 |
NEU1 |
Q99519 |
3.2.1.18
|
R-HSA-4085001
R-HSA-1660662
R-HSA-6798695
|
R-HSA-446219
R-HSA-446219
Reactome Name: Synthesis of substrates in N-glycan biosythesis
See in Reactome
R-HSA-446193
R-HSA-446193
Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
See in Reactome
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-168249
R-HSA-168256
R-HSA-392499
R-HSA-428157
R-HSA-1430728
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
|
Immune System
Metabolism of proteins
Metabolism
|
R-HSA-1605724
(
R-HSA-1660662
)
R-HSA-1605724
Reaction Name: Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen)
See in Reactome
R-HSA-4084999
(
R-HSA-4085001
)
R-HSA-4084999
Reaction Name: NEU1 hydrolyses Neu5Ac from glycoconjugates
See in Reactome
R-HSA-6798749
(
R-HSA-6798695
)
R-HSA-6798749
Reaction Name: Exocytosis of specific granule lumen proteins
See in Reactome
|
MONDO:0019681 |
NEU1 |
Q99519 |
3.2.1.18
|
R-HSA-4085001
R-HSA-1660662
R-HSA-6798695
|
R-HSA-446219
R-HSA-446219
Reactome Name: Synthesis of substrates in N-glycan biosythesis
See in Reactome
R-HSA-446193
R-HSA-446193
Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
See in Reactome
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-168249
R-HSA-168256
R-HSA-392499
R-HSA-428157
R-HSA-1430728
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
|
Immune System
Metabolism of proteins
Metabolism
|
R-HSA-1605724
(
R-HSA-1660662
)
R-HSA-1605724
Reaction Name: Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen)
See in Reactome
R-HSA-4084999
(
R-HSA-4085001
)
R-HSA-4084999
Reaction Name: NEU1 hydrolyses Neu5Ac from glycoconjugates
See in Reactome
R-HSA-6798749
(
R-HSA-6798695
)
R-HSA-6798749
Reaction Name: Exocytosis of specific granule lumen proteins
See in Reactome
|
MONDO:0019682 |
NEU1 |
Q99519 |
3.2.1.18
|
R-HSA-4085001
R-HSA-1660662
R-HSA-6798695
|
R-HSA-446219
R-HSA-446219
Reactome Name: Synthesis of substrates in N-glycan biosythesis
See in Reactome
R-HSA-446193
R-HSA-446193
Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
See in Reactome
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-168249
R-HSA-168256
R-HSA-392499
R-HSA-428157
R-HSA-1430728
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
|
Immune System
Metabolism of proteins
Metabolism
|
R-HSA-1605724
(
R-HSA-1660662
)
R-HSA-1605724
Reaction Name: Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen)
See in Reactome
R-HSA-4084999
(
R-HSA-4085001
)
R-HSA-4084999
Reaction Name: NEU1 hydrolyses Neu5Ac from glycoconjugates
See in Reactome
R-HSA-6798749
(
R-HSA-6798695
)
R-HSA-6798749
Reaction Name: Exocytosis of specific granule lumen proteins
See in Reactome
|
MONDO:0019732 |
LYZ |
P61626 |
3.2.1.17
|
R-HSA-6798695
R-HSA-977225
R-HSA-6803157
|
R-HSA-168249
R-HSA-168256
R-HSA-392499
|
Immune System
Metabolism of proteins
|
R-HSA-6798745
(
R-HSA-6798695
)
R-HSA-6798745
Reaction Name: Exocytosis of tertiary granule lumen proteins
See in Reactome
R-HSA-6798749
(
R-HSA-6798695
)
R-HSA-6798749
Reaction Name: Exocytosis of specific granule lumen proteins
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-8862300
(
R-HSA-6803157
)
R-HSA-8862300
Reaction Name: LYZ binds bacterial peptidoglycan
See in Reactome
R-HSA-8862320
(
R-HSA-6803157
)
R-HSA-8862320
Reaction Name: LYZ hydrolyzes peptidoglycans in the bacterial cell wall
See in Reactome
R-HSA-976734
(
R-HSA-977225
)
R-HSA-976734
Reaction Name: Amyloid fibrils have additional components
See in Reactome
R-HSA-977136
(
R-HSA-977225
)
R-HSA-977136
Reaction Name: Amyloid precursor proteins form ordered fibrils
See in Reactome
|
MONDO:0020734 |
AMPD3 |
Q01432 |
3.5.4.6
|
R-HSA-6798695
R-HSA-74217
|
R-HSA-168249
R-HSA-1430728
R-HSA-15869
R-HSA-168256
R-HSA-8956321
|
Metabolism
Immune System
|
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-76590
(
R-HSA-74217
)
|
MONDO:0021100 |
MONDO:0021100
Disease Name: breast neoplasm
All associated enzymes in DAR:
FGFR2
MTOR
FGFR4
ROCK1
RHOA
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0021100 |
MONDO:0021100
Disease Name: breast neoplasm
All associated enzymes in DAR:
FGFR2
MTOR
FGFR4
ROCK1
RHOA
ROCK1 |
Q13464 |
2.7.11.1
|
R-HSA-4420097
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-111465
R-HSA-111465
Reactome Name: Apoptotic cleavage of cellular proteins
See in Reactome
R-HSA-9696264
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-9013026
R-HSA-9013407
R-HSA-6798695
R-HSA-9013422
R-HSA-8980692
|
R-HSA-162582
R-HSA-195258
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-400685
R-HSA-9012999
R-HSA-194138
R-HSA-388396
R-HSA-109581
R-HSA-168256
R-HSA-194315
R-HSA-9675108
R-HSA-75153
R-HSA-9706574
R-HSA-5357801
R-HSA-168249
R-HSA-372790
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-2682334
R-HSA-1266738
|
Signal Transduction
Immune System
Programmed Cell Death
Developmental Biology
|
R-HSA-201611
(
R-HSA-111465
)
R-HSA-201611
Reaction Name: Caspase-mediated cleavage of Rock-1
See in Reactome
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013024
(
R-HSA-9013026
)
R-HSA-9013024
Reaction Name: RHOB binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9018778
(
R-HSA-9013422
)
R-HSA-9018778
Reaction Name: RHOBTB1 binds interacting proteins at the endosome membrane
See in Reactome
R-HSA-9680443
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-9696268
(
R-HSA-9696264
)
|
MONDO:0021571 |
PTPRC |
P08575 |
3.1.3.48
|
R-HSA-6798695
R-HSA-416700
R-HSA-202427
R-HSA-202427
Reactome Name: Phosphorylation of CD3 and TCR zeta chains
See in Reactome
|
R-HSA-168249
R-HSA-168256
R-HSA-9675108
R-HSA-202403
R-HSA-373755
R-HSA-422475
R-HSA-1280218
R-HSA-1266738
|
Immune System
Developmental Biology
|
R-HSA-202214
(
R-HSA-202427
)
R-HSA-202214
Reaction Name: Dephosphorylation of Lck-pY505 by CD45
See in Reactome
R-HSA-202233
(
R-HSA-202427
)
R-HSA-373746
(
R-HSA-416700
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
|
MONDO:0024498 |
IDH1 |
O75874 |
1.1.1.42
|
R-HSA-6798695
R-HSA-9033241
R-HSA-389542
|
R-HSA-168256
R-HSA-9609507
R-HSA-8978934
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-168249
R-HSA-1430728
|
Immune System
Protein localization
Metabolism
|
R-HSA-389540
(
R-HSA-389542
)
R-HSA-389540
Reaction Name: isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
See in Reactome
R-HSA-389550
(
R-HSA-389542
)
R-HSA-389550
Reaction Name: isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
See in Reactome
R-HSA-6798745
(
R-HSA-6798695
)
R-HSA-6798745
Reaction Name: Exocytosis of tertiary granule lumen proteins
See in Reactome
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-9033233
(
R-HSA-9033241
)
R-HSA-9033233
(
R-HSA-9033241
)
R-HSA-9033233
Reaction Name: PEX5S,L binds cargo proteins containing PTS1
See in Reactome
R-HSA-9033235
(
R-HSA-9033241
)
R-HSA-9033235
(
R-HSA-9033241
)
R-HSA-9033235
Reaction Name: Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix
See in Reactome
R-HSA-9033236
(
R-HSA-9033241
)
R-HSA-9033236
(
R-HSA-9033241
)
R-HSA-9033236
Reaction Name: PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)
See in Reactome
R-HSA-9761844
()
R-HSA-9761844
Reaction Name: NFE2L2-dependent IDH1 gene expression
See in Reactome
|
MONDO:0024573 |
GLA |
P06280 |
3.2.1.22
|
R-HSA-6798695
R-HSA-1660662
|
R-HSA-556833
R-HSA-168249
R-HSA-1430728
R-HSA-168256
R-HSA-428157
|
Metabolism
Immune System
|
R-HSA-1605736
(
R-HSA-1660662
)
R-HSA-1605736
Reaction Name: Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
|
MONDO:0030913 |
RAC1 |
P63000 |
3.6.5.2
|
R-HSA-376172
R-HSA-445144
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-9619229
R-HSA-9619229
Reactome Name: Activation of RAC1 downstream of NMDARs
See in Reactome
R-HSA-428540
R-HSA-428543
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-399954
R-HSA-399954
Reactome Name: Sema3A PAK dependent Axon repulsion
See in Reactome
R-HSA-9032845
R-HSA-9032845
Reactome Name: Activated NTRK2 signals through CDK5
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-6798695
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-193648
R-HSA-193648
Reactome Name: NRAGE signals death through JNK
See in Reactome
R-HSA-5625900
R-HSA-5625740
R-HSA-9032759
R-HSA-1257604
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-389359
R-HSA-5627123
R-HSA-399955
R-HSA-399955
Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
See in Reactome
R-HSA-5626467
R-HSA-4420097
R-HSA-5663220
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5687128
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1433557
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-2424491
R-HSA-9013149
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-8875555
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-3928664
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-8848021
R-HSA-1280218
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9675108
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-112316
R-HSA-8875878
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-373760
R-HSA-9032500
R-HSA-9032500
Reactome Name: Activated NTRK2 signals through FYN
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-168249
R-HSA-195258
R-HSA-199991
R-HSA-73887
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-2682334
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-5653656
R-HSA-6806834
R-HSA-195721
R-HSA-2172127
R-HSA-204998
R-HSA-204998
Reactome Name: Cell death signalling via NRAGE, NRIF and NADE
See in Reactome
R-HSA-373755
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Developmental Biology
Neuronal System
Vesicle-mediated transport
Hemostasis
Signal Transduction
|
R-HSA-1011598
(
R-HSA-983231
)
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1433415
(
R-HSA-1433557
)
R-HSA-2029451
(
R-HSA-2029482
)
R-HSA-2029454
(
R-HSA-2029482
)
R-HSA-2029456
(
R-HSA-2029482;
R-HSA-5627123
)
R-HSA-2029465
(
R-HSA-2029482;
R-HSA-4420097;
R-HSA-5663213
)
R-HSA-2029465
Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)
See in Reactome
R-HSA-2029466
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029466
Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin
See in Reactome
R-HSA-2029467
(
R-HSA-2029482
)
R-HSA-2029467
Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO
See in Reactome
R-HSA-2029469
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029469
Reaction Name: p-ERK phosphorylates WAVEs and ABI
See in Reactome
R-HSA-205039
(
R-HSA-193648
)
R-HSA-205039
Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
See in Reactome
R-HSA-205136
(
R-HSA-193648
)
R-HSA-205136
Reaction Name: GTP-bound RAC contributes to JNK activation
See in Reactome
R-HSA-2130194
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2197690
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2316352
(
R-HSA-1445148
)
R-HSA-2316352
Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424476
(
R-HSA-2424491
)
R-HSA-2730840
(
R-HSA-2871796
)
R-HSA-2730856
(
R-HSA-2871796
)
R-HSA-2730889
(
R-HSA-2871796
)
R-HSA-2730889
Reaction Name: Recruitment of PAK to the membrane by binding active RAC1
See in Reactome
R-HSA-376123
(
R-HSA-376172
)
R-HSA-376123
Reaction Name: DSCAM associates with Rac1-GTP:pPAK1
See in Reactome
R-HSA-3858475
(
R-HSA-4086400
)
R-HSA-389348
(
R-HSA-389359
)
R-HSA-389788
(
R-HSA-389359;
R-HSA-5687128
)
R-HSA-389788
Reaction Name: Activation of PAKs by RAC1 and CDC42
See in Reactome
R-HSA-3928612
(
R-HSA-3928662
)
R-HSA-3928612
Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928619
(
R-HSA-3928662
)
R-HSA-3928620
(
R-HSA-3928662
)
R-HSA-3928625
(
R-HSA-3928664
)
R-HSA-3928628
(
R-HSA-3928665
)
R-HSA-3928628
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928633
(
R-HSA-3928664
)
R-HSA-3928633
Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it
See in Reactome
R-HSA-3928640
(
R-HSA-3928664
)
R-HSA-3928641
(
R-HSA-3928664
)
R-HSA-3928642
(
R-HSA-3928665
)
R-HSA-3928642
Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-399928
(
R-HSA-399955
)
R-HSA-399928
Reaction Name: Recruitment of Rnd1 to Plexin A
See in Reactome
R-HSA-399930
(
R-HSA-399954
)
R-HSA-399935
(
R-HSA-399955
)
R-HSA-399935
Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity
See in Reactome
R-HSA-399938
(
R-HSA-399955
)
R-HSA-399939
(
R-HSA-399954
)
R-HSA-399941
(
R-HSA-399955
)
R-HSA-399952
(
R-HSA-399954
)
R-HSA-399952
Reaction Name: Phosphorylation of LIMK-1 by PAK
See in Reactome
R-HSA-400682
(
R-HSA-416550
)
R-HSA-400682
Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D
See in Reactome
R-HSA-4093336
(
R-HSA-3928662
)
R-HSA-4093336
Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-428522
(
R-HSA-428543
)
R-HSA-428535
(
R-HSA-428540
)
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442592
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-442592
Reaction Name: WASPs or WAVEs activate the ARP2/3 complex
See in Reactome
R-HSA-445064
(
R-HSA-445144
)
R-HSA-445072
(
R-HSA-445144
)
R-HSA-445072
Reaction Name: Interaction of PAK1 with Rac1-GTP
See in Reactome
R-HSA-451347
(
R-HSA-376172
)
R-HSA-451366
(
R-HSA-376172
)
R-HSA-5218827
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218827
Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1
See in Reactome
R-HSA-5218839
(
R-HSA-4420097
)
R-HSA-5218839
Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1
See in Reactome
R-HSA-5218841
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218841
Reaction Name: NADPH oxidase 2 generates superoxide from oxygen
See in Reactome
R-HSA-5218850
(
R-HSA-4420097
)
R-HSA-5218850
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-5357445
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357472
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357483
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5626469
(
R-HSA-5626467
)
R-HSA-5626469
Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs
See in Reactome
R-HSA-5626507
(
R-HSA-5626467
)
R-HSA-5626507
Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin
See in Reactome
R-HSA-5626549
(
R-HSA-5626467
)
R-HSA-5627775
(
R-HSA-5627123;
R-HSA-5687128
)
R-HSA-5627775
Reaction Name: Autophosphorylation of PAK1,2,3
See in Reactome
R-HSA-5663232
(
R-HSA-5663220
)
R-HSA-5665659
(
R-HSA-5663220
)
R-HSA-5665659
Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin
See in Reactome
R-HSA-5665802
(
R-HSA-5663220
)
R-HSA-5665802
Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin
See in Reactome
R-HSA-5665809
(
R-HSA-5663220
)
R-HSA-5665809
Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments
See in Reactome
R-HSA-5668714
(
R-HSA-5668599
)
R-HSA-5668718
(
R-HSA-5668599
)
R-HSA-5668718
Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen
See in Reactome
R-HSA-5668731
(
R-HSA-5668599
)
R-HSA-5668731
Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen
See in Reactome
R-HSA-5668735
(
R-HSA-5668599
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5672304
(
R-HSA-5626467
)
R-HSA-5672304
Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1
See in Reactome
R-HSA-5672329
(
R-HSA-5626467
)
R-HSA-5672329
Reaction Name: IQGAP1 binds CLIP1 and microtubules
See in Reactome
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8848618
(
R-HSA-8849471
)
R-HSA-8848618
Reaction Name: Activation of RAC1 by the PXN:CRK complex
See in Reactome
R-HSA-8875591
(
R-HSA-8875555
)
R-HSA-8951586
(
R-HSA-4420097
)
R-HSA-8951586
Reaction Name: p-VAV family:PIP3 binds RAC1:GDP
See in Reactome
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981926
(
R-HSA-5627123
)
R-HSA-8981931
(
R-HSA-5627123
)
R-HSA-9013143
(
R-HSA-9013149
)
R-HSA-9013144
(
R-HSA-9013149
)
R-HSA-9013144
Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9013147
(
R-HSA-9013149
)
R-HSA-9013147
Reaction Name: RAC1 GDIs block activation of RAC1
See in Reactome
R-HSA-9032798
(
R-HSA-9032759
)
R-HSA-9033292
(
R-HSA-9032845
)
R-HSA-9033292
Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1
See in Reactome
R-HSA-9619803
(
R-HSA-9619229
)
R-HSA-9691168
(
R-HSA-9013149
)
R-HSA-9691168
Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane
See in Reactome
R-HSA-9691174
(
R-HSA-9013149
)
R-HSA-9691174
Reaction Name: RAC1 binds effectors at the ER membrane
See in Reactome
|
MONDO:0032730 |
DEGS1 |
O15121 |
1.14.19.17
5.2.1.-
|
R-HSA-6798695
R-HSA-1660661
R-HSA-1660661
Reactome Name: Sphingolipid de novo biosynthesis
See in Reactome
|
R-HSA-556833
R-HSA-168249
R-HSA-1430728
R-HSA-168256
R-HSA-428157
|
Metabolism
Immune System
|
R-HSA-428259
(
R-HSA-1660661
)
R-HSA-428259
Reaction Name: dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O
See in Reactome
R-HSA-6799350
(
R-HSA-6798695
)
R-HSA-6799350
Reaction Name: Exocytosis of specific granule membrane proteins
See in Reactome
|
MONDO:0032792 |
PDXK |
O00764 |
2.7.1.35
|
R-HSA-6798695
R-HSA-964975
R-HSA-964975
Reactome Name: Vitamins B6 activation to pyridoxal phosphate
See in Reactome
|
R-HSA-168249
R-HSA-1430728
R-HSA-196849
R-HSA-196849
Reactome Name: Metabolism of water-soluble vitamins and cofactors
See in Reactome
R-HSA-168256
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
|
Metabolism
Immune System
|
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6798749
(
R-HSA-6798695
)
R-HSA-6798749
Reaction Name: Exocytosis of specific granule lumen proteins
See in Reactome
R-HSA-964958
(
R-HSA-964975
)
R-HSA-964958
Reaction Name: 2xPDXK:2xZn2+ phosphorylates PXA
See in Reactome
R-HSA-964962
(
R-HSA-964975
)
R-HSA-964962
Reaction Name: 2xPDKX:2xZn2+ phosphorylates PDX
See in Reactome
R-HSA-964970
(
R-HSA-964975
)
R-HSA-964970
Reaction Name: 2xPDXK:2xZn2+ phosphorylates PXL
See in Reactome
|
MONDO:0032884 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0033669 |
MAPK1 |
P28482 |
2.7.11.24
|
R-HSA-2559585
R-HSA-445144
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-111995
R-HSA-2559580
R-HSA-2559580
Reactome Name: Oxidative Stress Induced Senescence
See in Reactome
R-HSA-198753
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-8940973
R-HSA-8940973
Reactome Name: RUNX2 regulates osteoblast differentiation
See in Reactome
R-HSA-170968
R-HSA-437239
R-HSA-444257
R-HSA-6798695
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-1181150
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-982772
R-HSA-982772
Reactome Name: Growth hormone receptor signaling
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-2559582
R-HSA-2559582
Reactome Name: Senescence-Associated Secretory Phenotype (SASP)
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-5673001
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-2173796
R-HSA-2173796
Reactome Name: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
See in Reactome
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
R-HSA-1502540
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-450341
R-HSA-450341
Reactome Name: Activation of the AP-1 family of transcription factors
See in Reactome
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-74749
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-8939211
R-HSA-5674135
R-HSA-202670
R-HSA-879415
R-HSA-879415
Reactome Name: Advanced glycosylation endproduct receptor signaling
See in Reactome
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-162658
R-HSA-162658
Reactome Name: Golgi Cisternae Pericentriolar Stack Reorganization
See in Reactome
R-HSA-456926
R-HSA-456926
Reactome Name: Thrombin signalling through proteinase activated receptors (PARs)
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-112411
R-HSA-9627069
R-HSA-9627069
Reactome Name: Regulation of the apoptosome activity
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-111996
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-1640170
R-HSA-1266738
R-HSA-73857
R-HSA-212436
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-2262752
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-112316
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-373760
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-450294
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-416476
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-111471
R-HSA-111471
Reactome Name: Apoptotic factor-mediated response
See in Reactome
R-HSA-168256
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-450282
R-HSA-450282
Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases
See in Reactome
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-111461
R-HSA-111461
Reactome Name: Cytochrome c-mediated apoptotic response
See in Reactome
R-HSA-69278
R-HSA-198725
R-HSA-198725
Reactome Name: Nuclear Events (kinase and transcription factor activation)
See in Reactome
R-HSA-166166
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-168249
R-HSA-68886
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-187037
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-112043
R-HSA-112040
R-HSA-5654738
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-422475
R-HSA-68875
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-2559583
R-HSA-8941326
R-HSA-8941326
Reactome Name: RUNX2 regulates bone development
See in Reactome
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-5357801
R-HSA-74752
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-74160
R-HSA-168898
R-HSA-2173793
R-HSA-2173793
Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-8953897
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-111885
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-187687
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
R-HSA-449147
R-HSA-418594
R-HSA-194315
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-5684996
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-5654743
R-HSA-5654741
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-190236
R-HSA-388396
R-HSA-5654736
R-HSA-195258
R-HSA-1257604
R-HSA-372790
R-HSA-6807070
R-HSA-448424
R-HSA-109581
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-111458
R-HSA-109582
R-HSA-162582
|
Cell Cycle
Developmental Biology
Neuronal System
Immune System
Programmed Cell Death
Gene expression (Transcription)
Cellular responses to stimuli
Hemostasis
Signal Transduction
|
R-HSA-109822
(
R-HSA-74749
)
R-HSA-109822
Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1
See in Reactome
R-HSA-109823
(
R-HSA-74749
)
R-HSA-109823
Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2
See in Reactome
R-HSA-109858
(
R-HSA-112409;
R-HSA-112411
)
R-HSA-109862
(
R-HSA-112409;
R-HSA-112411;
R-HSA-445144
)
R-HSA-109864
(
R-HSA-112409;
R-HSA-112411
)
R-HSA-109864
Reaction Name: Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2
See in Reactome
R-HSA-111898
(
R-HSA-111995
)
R-HSA-111898
Reaction Name: Phosphorylation of cPLA2 by ERK-2
See in Reactome
R-HSA-1168459
(
R-HSA-982772
)
R-HSA-1295634
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-168053
(
R-HSA-166058;
R-HSA-168188;
R-HSA-450341
)
R-HSA-168053
Reaction Name: Phosphorylated MAPKs phosphorylate ATF-2
See in Reactome
R-HSA-173488
(
R-HSA-1181150;
R-HSA-1502540;
R-HSA-2173796
)
R-HSA-173488
Reaction Name: The SMAD2/3:SMAD4 complex transfers to the nucleus
See in Reactome
R-HSA-198731
(
R-HSA-166058;
R-HSA-168188;
R-HSA-198753;
R-HSA-8939211;
R-HSA-9634638
)
R-HSA-198746
(
R-HSA-166058;
R-HSA-168188;
R-HSA-198753;
R-HSA-2559582;
R-HSA-881907
)
R-HSA-198756
(
R-HSA-166058;
R-HSA-168188;
R-HSA-198753;
R-HSA-375165
)
R-HSA-199959
(
R-HSA-166058;
R-HSA-168188;
R-HSA-198753;
R-HSA-202670
)
R-HSA-199959
Reaction Name: ERKs are inactivated by protein phosphatase 2A
See in Reactome
R-HSA-2029469
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029469
Reaction Name: p-ERK phosphorylates WAVEs and ABI
See in Reactome
R-HSA-203797
(
R-HSA-166058;
R-HSA-168188;
R-HSA-198753;
R-HSA-202670
)
R-HSA-203797
Reaction Name: ERKs are inactivated by dual-specific phosphatases (DUSPs)
See in Reactome
R-HSA-2422927
(
R-HSA-162658
)
R-HSA-2422927
Reaction Name: MAPK3-3 or MAPK1 phosphorylate GORASP2
See in Reactome
R-HSA-3132737
(
R-HSA-2559585
)
R-HSA-3132737
Reaction Name: MAPKs phosphorylate ETS1 and ETS2
See in Reactome
R-HSA-3209160
(
R-HSA-2559585
)
R-HSA-3209160
Reaction Name: Activated ERKs phosphorylate ERF
See in Reactome
R-HSA-3209177
(
R-HSA-2559585
)
R-HSA-3223236
(
R-HSA-2559580
)
R-HSA-3223236
Reaction Name: RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS)
See in Reactome
R-HSA-3371531
(
R-HSA-3371453
)
R-HSA-3371531
Reaction Name: Constitutive phosphorylation by pERK1/2
See in Reactome
R-HSA-3857329
(
R-HSA-2559582
)
R-HSA-3857329
Reaction Name: MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB
See in Reactome
R-HSA-418158
(
R-HSA-456926
)
R-HSA-418158
Reaction Name: SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1)
See in Reactome
R-HSA-418163
(
R-HSA-456926
)
R-HSA-418163
Reaction Name: Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)
See in Reactome
R-HSA-418170
(
R-HSA-456926
)
R-HSA-418176
(
R-HSA-456926
)
R-HSA-418200
(
R-HSA-456926
)
R-HSA-418200
Reaction Name: SRC-1 bound to ARRB2 is not activated
See in Reactome
R-HSA-445079
(
R-HSA-437239
)
R-HSA-450325
(
R-HSA-166058;
R-HSA-168188;
R-HSA-2559580;
R-HSA-2871796;
R-HSA-450341
)
R-HSA-450325
Reaction Name: c-FOS activation by phospho ERK1/2
See in Reactome
R-HSA-5654560
(
R-HSA-5654726
)
R-HSA-5654560
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2.
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654565
(
R-HSA-5654732
)
R-HSA-5654565
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2.
See in Reactome
R-HSA-5654566
(
R-HSA-5654733
)
R-HSA-5654566
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2.
See in Reactome
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674366
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674366
Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs
See in Reactome
R-HSA-5674373
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674373
Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane
See in Reactome
R-HSA-5674385
(
R-HSA-112409;
R-HSA-170968;
R-HSA-5673001
)
R-HSA-5674387
(
R-HSA-112409;
R-HSA-5673001
)
R-HSA-5674387
Reaction Name: Phosphorylated MAPKs translocate into the nucleus
See in Reactome
R-HSA-5674496
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5674496
Reaction Name: Activated MAPKs phosphorylate MAP2K1
See in Reactome
R-HSA-5675194
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675194
Reaction Name: Activated MAPK phosphorylates RAF1
See in Reactome
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675206
(
R-HSA-112409;
R-HSA-5673001
)
R-HSA-5675206
Reaction Name: PEA15 binds MAPK monomers and dimers
See in Reactome
R-HSA-5675373
(
R-HSA-112409;
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675373
Reaction Name: Nuclear DUSPs dephosphorylate MAPKs
See in Reactome
R-HSA-5675376
(
R-HSA-112409;
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675376
Reaction Name: Cytosolic DUSPs dephosphorylate MAPKs
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-6811454
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-6811472
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-6811472
Reaction Name: IER3 recruits MAPKs to PP2A-B56-beta,gamma
See in Reactome
R-HSA-879362
(
R-HSA-879415
)
R-HSA-8944047
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944047
Reaction Name: JUN binds the PTEN gene promoter
See in Reactome
R-HSA-9009208
(
R-HSA-8940973
)
R-HSA-9009208
Reaction Name: Activated ERKs phosphorylate RUNX2
See in Reactome
R-HSA-9032751
(
R-HSA-8939211
)
R-HSA-9032751
Reaction Name: Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610166
(
R-HSA-170968
)
R-HSA-9610166
Reaction Name: p-T,Y MAPK dimers translocate to nucleus
See in Reactome
R-HSA-9619843
(
R-HSA-444257
)
R-HSA-9626832
(
R-HSA-5668599
)
R-HSA-9626832
Reaction Name: MAPK1 or MAPK3 phosphorylates NCF1 at Ser345
See in Reactome
R-HSA-9627089
(
R-HSA-9627069
)
R-HSA-9627089
Reaction Name: CASP9 is phosphorylated at T125
See in Reactome
R-HSA-9632873
(
R-HSA-8939211;
R-HSA-9634638
)
R-HSA-9632873
Reaction Name: p-S10 CDKN1B translocates to the cytosol
See in Reactome
R-HSA-9632910
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9635739
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-9635739
Reaction Name: PTPN7 dephosphorylates p-T,Y-MAPKs
See in Reactome
R-HSA-9635743
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
|
MONDO:0035124 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0042490 |
ELANE |
P08246 |
3.4.21.37
|
R-HSA-5620971
R-HSA-977606
R-HSA-977606
Reactome Name: Regulation of Complement cascade
See in Reactome
R-HSA-1474228
R-HSA-1474228
Reactome Name: Degradation of the extracellular matrix
See in Reactome
R-HSA-1442490
R-HSA-1592389
R-HSA-1592389
Reactome Name: Activation of Matrix Metalloproteinases
See in Reactome
R-HSA-6803157
R-HSA-6798695
|
R-HSA-168249
R-HSA-168256
R-HSA-5218859
R-HSA-5357801
R-HSA-1474244
R-HSA-1474244
Reactome Name: Extracellular matrix organization
See in Reactome
R-HSA-166658
|
Immune System
Programmed Cell Death
Extracellular matrix organization
|
R-HSA-1566962
(
R-HSA-1474228
)
R-HSA-1566962
Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases
See in Reactome
R-HSA-1592270
(
R-HSA-1474228
)
R-HSA-1592270
Reaction Name: NID1 degradation by MMP1, 9, 12, ELANE
See in Reactome
R-HSA-1592316
(
R-HSA-1474228;
R-HSA-1592389
)
R-HSA-1592398
(
R-HSA-1474228;
R-HSA-1592389
)
R-HSA-1604712
(
R-HSA-1474228;
R-HSA-1592389
)
R-HSA-1604712
Reaction Name: Initial activation of proMMP7 by trypsin
See in Reactome
R-HSA-2482180
(
R-HSA-1442490;
R-HSA-1474228
)
R-HSA-2482180
Reaction Name: Collagen type VIII degradation by ELANE
See in Reactome
R-HSA-2514823
(
R-HSA-1474228
)
R-HSA-2514823
Reaction Name: Fibrillin-1 degradation by ELANE
See in Reactome
R-HSA-6798749
(
R-HSA-6798695
)
R-HSA-6798749
Reaction Name: Exocytosis of specific granule lumen proteins
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6813659
(
R-HSA-6803157
)
R-HSA-6813659
Reaction Name: ELANE, CTSG or PRTN3 binds bacteria
See in Reactome
R-HSA-8852716
(
R-HSA-977606
)
R-HSA-9710106
(
R-HSA-5620971
)
|
MONDO:0043364 |
EPX |
P11678 |
1.11.1.7
|
R-HSA-6798695
|
R-HSA-168249
R-HSA-168256
|
Immune System
|
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
|
MONDO:0044302 |
CDK13 |
Q14004 |
2.7.11.22
2.7.11.23
|
R-HSA-6798695
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-212436
R-HSA-168256
R-HSA-168249
R-HSA-74160
R-HSA-73857
|
Immune System
Gene expression (Transcription)
|
R-HSA-6797100
(
R-HSA-6796648
)
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
|
MONDO:0044339 |
MMP9 |
P14780 |
3.4.24.35
|
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-1474228
R-HSA-1474228
Reactome Name: Degradation of the extracellular matrix
See in Reactome
R-HSA-1433557
R-HSA-1592389
R-HSA-1592389
Reactome Name: Activation of Matrix Metalloproteinases
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-6798695
R-HSA-2022090
R-HSA-2022090
Reactome Name: Assembly of collagen fibrils and other multimeric structures
See in Reactome
R-HSA-1442490
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
|
R-HSA-449147
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-168249
R-HSA-168256
R-HSA-9675108
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-1474244
R-HSA-1474244
Reactome Name: Extracellular matrix organization
See in Reactome
R-HSA-8939211
R-HSA-162582
R-HSA-1474290
R-HSA-422475
R-HSA-2682334
R-HSA-1266738
|
Immune System
Extracellular matrix organization
Signal Transduction
Developmental Biology
|
R-HSA-1433374
(
R-HSA-1433557
)
R-HSA-1454757
(
R-HSA-1442490;
R-HSA-1474228
)
R-HSA-1454757
Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13
See in Reactome
R-HSA-1454781
(
R-HSA-1474228
)
R-HSA-1454781
Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin
See in Reactome
R-HSA-1454791
(
R-HSA-1474228
)
R-HSA-1474213
(
R-HSA-1442490;
R-HSA-1474228
)
R-HSA-1474213
Reaction Name: Collagen type III degradation by MMP1,8,9,13
See in Reactome
R-HSA-1564112
(
R-HSA-1442490;
R-HSA-1474228
)
R-HSA-1564112
Reaction Name: Collagen type VI degradation by MMP2,9,11
See in Reactome
R-HSA-1564117
(
R-HSA-1442490;
R-HSA-1474228
)
R-HSA-1564117
Reaction Name: Collagen type XIV degradation by MMP9,13
See in Reactome
R-HSA-1564142
(
R-HSA-1442490;
R-HSA-1474228
)
R-HSA-1564142
Reaction Name: Collagen type IV degradation by MMP2,3,4,9,10,12
See in Reactome
R-HSA-1564164
(
R-HSA-1442490;
R-HSA-1474228
)
R-HSA-1564164
Reaction Name: Collagen type V degradation by MMP2,9,10
See in Reactome
R-HSA-1564179
(
R-HSA-1442490;
R-HSA-1474228
)
R-HSA-1564179
Reaction Name: Collagen type XI degradation by MMP1,2,3,9
See in Reactome
R-HSA-1566962
(
R-HSA-1474228
)
R-HSA-1566962
Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases
See in Reactome
R-HSA-1592270
(
R-HSA-1474228
)
R-HSA-1592270
Reaction Name: NID1 degradation by MMP1, 9, 12, ELANE
See in Reactome
R-HSA-1592436
(
R-HSA-1474228;
R-HSA-1592389
)
R-HSA-1592436
Reaction Name: Initial activation of proMMP9 by MMPs
See in Reactome
R-HSA-1602454
(
R-HSA-1474228;
R-HSA-1592389
)
R-HSA-1604690
(
R-HSA-1474228;
R-HSA-1592389
)
R-HSA-1604690
Reaction Name: Activation of MMP9 intermediate form by MMPs
See in Reactome
R-HSA-1604722
(
R-HSA-1474228;
R-HSA-1592389
)
R-HSA-1604722
Reaction Name: Activation of proMMP9 by proteases
See in Reactome
R-HSA-2168923
(
R-HSA-1442490;
R-HSA-1474228
)
R-HSA-2168923
Reaction Name: Collagen type XVIII endostatin release
See in Reactome
R-HSA-2168982
(
R-HSA-1442490;
R-HSA-1474228
)
R-HSA-2168982
Reaction Name: Collagen type XVI degradation by MMP9
See in Reactome
R-HSA-2213200
(
R-HSA-2022090
)
R-HSA-2213200
Reaction Name: Release of endostatin-like peptides
See in Reactome
R-HSA-2485148
(
R-HSA-1474228
)
R-HSA-2485148
Reaction Name: Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13
See in Reactome
R-HSA-3791295
(
R-HSA-1474228
)
R-HSA-3791295
Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13
See in Reactome
R-HSA-3827958
(
R-HSA-1474228
)
R-HSA-3827958
Reaction Name: E-cadherin degradation by MMP9, KLK7
See in Reactome
R-HSA-3928657
(
R-HSA-3928665
)
R-HSA-6789615
(
R-HSA-6785807
)
R-HSA-6789615
Reaction Name: Expression of STAT3-upregulated extracellular proteins
See in Reactome
R-HSA-6798745
(
R-HSA-6798695
)
R-HSA-6798745
Reaction Name: Exocytosis of tertiary granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-8943959
(
R-HSA-1474228
)
R-HSA-9624272
(
R-HSA-8939211;
R-HSA-9009391
)
|
MONDO:0044640 |
MME |
P08473 |
3.4.24.11
|
R-HSA-6798695
R-HSA-2022377
R-HSA-2022377
Reactome Name: Metabolism of Angiotensinogen to Angiotensins
See in Reactome
|
R-HSA-168249
R-HSA-168256
R-HSA-2980736
R-HSA-392499
|
Immune System
Metabolism of proteins
|
R-HSA-2022368
(
R-HSA-2022377
)
R-HSA-2022368
Reaction Name: MME:Zn2+ hydrolyses AGT(34-42)
See in Reactome
R-HSA-2022396
(
R-HSA-2022377
)
R-HSA-2022396
Reaction Name: MME:Zn2+ hydrolyses AGT(34-43)
See in Reactome
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
|
MONDO:0044657 |
MME |
P08473 |
3.4.24.11
|
R-HSA-6798695
R-HSA-2022377
R-HSA-2022377
Reactome Name: Metabolism of Angiotensinogen to Angiotensins
See in Reactome
|
R-HSA-168249
R-HSA-168256
R-HSA-2980736
R-HSA-392499
|
Immune System
Metabolism of proteins
|
R-HSA-2022368
(
R-HSA-2022377
)
R-HSA-2022368
Reaction Name: MME:Zn2+ hydrolyses AGT(34-42)
See in Reactome
R-HSA-2022396
(
R-HSA-2022377
)
R-HSA-2022396
Reaction Name: MME:Zn2+ hydrolyses AGT(34-43)
See in Reactome
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
|
MONDO:0044792 |
NRAS |
P01111 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-6798695
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-202733;
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392;
R-HSA-881907
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
|
MONDO:0054680 |
CANT1 |
Q8WVQ1 |
3.6.1.6
|
R-HSA-6798695
|
R-HSA-168249
R-HSA-168256
|
Immune System
|
R-HSA-6798745
(
R-HSA-6798695
)
R-HSA-6798745
Reaction Name: Exocytosis of tertiary granule lumen proteins
See in Reactome
R-HSA-6798749
(
R-HSA-6798695
)
R-HSA-6798749
Reaction Name: Exocytosis of specific granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
|
MONDO:0060596 |
HUWE1 |
Q7Z6Z7 |
2.3.2.26
|
R-HSA-6798695
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
|
R-HSA-168249
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-168256
R-HSA-1280218
|
Immune System
|
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-983140
(
R-HSA-983168
)
R-HSA-983140
Reaction Name: Transfer of Ub from E2 to substrate and release of E2
See in Reactome
R-HSA-983147
(
R-HSA-983168
)
R-HSA-983147
Reaction Name: Release of E3 from polyubiquitinated substrate
See in Reactome
R-HSA-983156
(
R-HSA-983168
)
R-HSA-983156
Reaction Name: Polyubiquitination of substrate
See in Reactome
R-HSA-983157
(
R-HSA-983168
)
R-HSA-983157
Reaction Name: Interaction of E3 with substrate and E2-Ub complex
See in Reactome
|