DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-6787450)

Number of enzymes:	6
Number of disease:	9
Number of reactomes:	5
Number of reactions:	11

Search results (Reactome ID: R-HSA-6787450)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009300	PRORP	O15091	3.1.26.5	R-HSA-6785470 R-HSA-6785470 Reactome Name: tRNA processing in the mitochondrion See in Reactome R-HSA-6787450 R-HSA-6787450 Reactome Name: tRNA modification in the mitochondrion See in Reactome R-HSA-8868766 R-HSA-8868766 Reactome Name: rRNA processing in the mitochondrion See in Reactome	R-HSA-72306 R-HSA-72306 Reactome Name: tRNA processing See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-72312 R-HSA-72312 Reactome Name: rRNA processing See in Reactome	Metabolism of RNA	R-HSA-6785722 ( R-HSA-6785470; R-HSA-8868766 ) R-HSA-6785722 Reaction Name: Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript See in Reactome R-HSA-6786854 ( R-HSA-6785470 ) R-HSA-6786854 Reaction Name: Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript See in Reactome R-HSA-6787591 ( R-HSA-6787450 ) R-HSA-6787591 Reaction Name: TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9 See in Reactome R-HSA-6787594 ( R-HSA-6787450 ) R-HSA-6787594 Reaction Name: TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9 See in Reactome
MONDO:0010780	TRMU	O75648	2.8.1.14	R-HSA-6787450 R-HSA-6787450 Reactome Name: tRNA modification in the mitochondrion See in Reactome	R-HSA-72306 R-HSA-72306 Reactome Name: tRNA processing See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome	Metabolism of RNA	R-HSA-6787447 ( R-HSA-6787450 ) R-HSA-6787447 Reaction Name: TRMU (MTO2, MTU1) transfers a sulfur atom to 5-taurinomethyluridine-34 in tRNA See in Reactome
MONDO:0010799	TRMU	O75648	2.8.1.14	R-HSA-6787450 R-HSA-6787450 Reactome Name: tRNA modification in the mitochondrion See in Reactome	R-HSA-72306 R-HSA-72306 Reactome Name: tRNA processing See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome	Metabolism of RNA	R-HSA-6787447 ( R-HSA-6787450 ) R-HSA-6787447 Reaction Name: TRMU (MTO2, MTU1) transfers a sulfur atom to 5-taurinomethyluridine-34 in tRNA See in Reactome
MONDO:0013111	TRMU	O75648	2.8.1.14	R-HSA-6787450 R-HSA-6787450 Reactome Name: tRNA modification in the mitochondrion See in Reactome	R-HSA-72306 R-HSA-72306 Reactome Name: tRNA processing See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome	Metabolism of RNA	R-HSA-6787447 ( R-HSA-6787450 ) R-HSA-6787447 Reaction Name: TRMU (MTO2, MTU1) transfers a sulfur atom to 5-taurinomethyluridine-34 in tRNA See in Reactome
MONDO:0014856	TRMT10C	Q7L0Y3	2.1.1.218 2.1.1.221 2.1.1.-	R-HSA-6785470 R-HSA-6785470 Reactome Name: tRNA processing in the mitochondrion See in Reactome R-HSA-6787450 R-HSA-6787450 Reactome Name: tRNA modification in the mitochondrion See in Reactome R-HSA-8868766 R-HSA-8868766 Reactome Name: rRNA processing in the mitochondrion See in Reactome	R-HSA-72306 R-HSA-72306 Reactome Name: tRNA processing See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-72312 R-HSA-72312 Reactome Name: rRNA processing See in Reactome	Metabolism of RNA	R-HSA-6785722 ( R-HSA-6785470; R-HSA-8868766 ) R-HSA-6785722 Reaction Name: Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript See in Reactome R-HSA-6786854 ( R-HSA-6785470 ) R-HSA-6786854 Reaction Name: Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript See in Reactome R-HSA-6787591 ( R-HSA-6787450 ) R-HSA-6787591 Reaction Name: TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9 See in Reactome R-HSA-6787594 ( R-HSA-6787450 ) R-HSA-6787594 Reaction Name: TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9 See in Reactome
MONDO:0018322	HSD17B10	Q99714	1.1.1.62 1.1.1.35 1.1.1.239 1.1.1.178 1.1.1.159 1.1.1.53	R-HSA-6785470 R-HSA-6785470 Reactome Name: tRNA processing in the mitochondrion See in Reactome R-HSA-70895 R-HSA-70895 Reactome Name: Branched-chain amino acid catabolism See in Reactome R-HSA-6787450 R-HSA-6787450 Reactome Name: tRNA modification in the mitochondrion See in Reactome R-HSA-8868766 R-HSA-8868766 Reactome Name: rRNA processing in the mitochondrion See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-72312 R-HSA-72312 Reactome Name: rRNA processing See in Reactome R-HSA-72306 R-HSA-72306 Reactome Name: tRNA processing See in Reactome	Metabolism of RNA Metabolism	R-HSA-508369 ( R-HSA-70895 ) R-HSA-508369 Reaction Name: alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ See in Reactome R-HSA-6785722 ( R-HSA-6785470; R-HSA-8868766 ) R-HSA-6785722 Reaction Name: Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript See in Reactome R-HSA-6786854 ( R-HSA-6785470 ) R-HSA-6786854 Reaction Name: Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript See in Reactome R-HSA-6787591 ( R-HSA-6787450 ) R-HSA-6787591 Reaction Name: TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9 See in Reactome R-HSA-6787594 ( R-HSA-6787450 ) R-HSA-6787594 Reaction Name: TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9 See in Reactome R-HSA-70837 ( R-HSA-70895 ) R-HSA-70837 Reaction Name: alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ See in Reactome
MONDO:0018323	HSD17B10	Q99714	1.1.1.62 1.1.1.35 1.1.1.239 1.1.1.178 1.1.1.159 1.1.1.53	R-HSA-6785470 R-HSA-6785470 Reactome Name: tRNA processing in the mitochondrion See in Reactome R-HSA-70895 R-HSA-70895 Reactome Name: Branched-chain amino acid catabolism See in Reactome R-HSA-6787450 R-HSA-6787450 Reactome Name: tRNA modification in the mitochondrion See in Reactome R-HSA-8868766 R-HSA-8868766 Reactome Name: rRNA processing in the mitochondrion See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-72312 R-HSA-72312 Reactome Name: rRNA processing See in Reactome R-HSA-72306 R-HSA-72306 Reactome Name: tRNA processing See in Reactome	Metabolism of RNA Metabolism	R-HSA-508369 ( R-HSA-70895 ) R-HSA-508369 Reaction Name: alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ See in Reactome R-HSA-6785722 ( R-HSA-6785470; R-HSA-8868766 ) R-HSA-6785722 Reaction Name: Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript See in Reactome R-HSA-6786854 ( R-HSA-6785470 ) R-HSA-6786854 Reaction Name: Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript See in Reactome R-HSA-6787591 ( R-HSA-6787450 ) R-HSA-6787591 Reaction Name: TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9 See in Reactome R-HSA-6787594 ( R-HSA-6787450 ) R-HSA-6787594 Reaction Name: TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9 See in Reactome R-HSA-70837 ( R-HSA-70895 ) R-HSA-70837 Reaction Name: alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ See in Reactome
MONDO:0024553	PUS1	Q9Y606	5.4.99.12	R-HSA-6787450 R-HSA-6787450 Reactome Name: tRNA modification in the mitochondrion See in Reactome R-HSA-6782315 R-HSA-6782315 Reactome Name: tRNA modification in the nucleus and cytosol See in Reactome	R-HSA-72306 R-HSA-72306 Reactome Name: tRNA processing See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome	Metabolism of RNA	R-HSA-6782381 ( R-HSA-6782315 ) R-HSA-6782381 Reaction Name: PUS1 isoform 2 transforms uridine residues to pseudouridine in the anticodon stems of tRNAs See in Reactome R-HSA-6787566 ( R-HSA-6787450 ) R-HSA-6787566 Reaction Name: PUS1 isoform 1 transforms uridine-27 See in Reactome
MONDO:0054742	TRIT1	Q9H3H1	2.5.1.75	R-HSA-6787450 R-HSA-6787450 Reactome Name: tRNA modification in the mitochondrion See in Reactome R-HSA-6782315 R-HSA-6782315 Reactome Name: tRNA modification in the nucleus and cytosol See in Reactome	R-HSA-72306 R-HSA-72306 Reactome Name: tRNA processing See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome	Metabolism of RNA	R-HSA-6784462 ( R-HSA-6782315 ) R-HSA-6784462 Reaction Name: TRIT1 transfers dimethylallyl group to adenosine-37 of tRNAs See in Reactome R-HSA-6787567 ( R-HSA-6787450 ) R-HSA-6787567 Reaction Name: TRIT1 transfers dimethylallyl group to adenosine-37 of tRNA(Ser) See in Reactome