DAR - Bologna Biocomputing Group

Search results (Reactome ID: R-HSA-6785807)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005029	JAK2	O60674	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-9027277 R-HSA-9027277 Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG) See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-9027283 R-HSA-9027283 Reactome Name: Erythropoietin activates STAT5 See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-3214858 R-HSA-3214858 Reactome Name: RMTs methylate histone arginines See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Chromatin organization Cell Cycle Hemostasis Signal Transduction	R-HSA-1168456 ( R-HSA-982772 ) R-HSA-1168456 Reaction Name: Growth hormone receptor binds Lyn See in Reactome R-HSA-8983870 ( R-HSA-8984722 ) R-HSA-8983870 Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated See in Reactome R-HSA-2671862 ( R-HSA-2586552 ) R-HSA-2671862 Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin See in Reactome R-HSA-6786070 ( R-HSA-6785807 ) R-HSA-6786070 Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950737 ( R-HSA-9020933 ) R-HSA-8950737 Reaction Name: IL23R binds JAK2 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8950423 ( R-HSA-9020591 ) R-HSA-8950423 Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-2586555 ( R-HSA-2586552 ) R-HSA-2586555 Reaction Name: JAK2 Autophosphorylates in Response to Leptin See in Reactome R-HSA-1370500 ( R-HSA-1170546 ) R-HSA-1370500 Reaction Name: PRLR binds SCF beta-TrCP complex See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-1169192 ( R-HSA-982772 ) R-HSA-1169192 Reaction Name: PTP1B dephosphorylates GHR See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-9012651 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012651 Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-6785898 ( R-HSA-6785807 ) R-HSA-6785898 Reaction Name: IL4R binds JAK2 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-2672302 ( R-HSA-2586552 ) R-HSA-2672302 Reaction Name: Phosphorylated LEPR Binds SOCS3 See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-8950063 ( R-HSA-9020591 ) R-HSA-8950063 Reaction Name: IL12RB2 binds JAK2 See in Reactome R-HSA-921155 ( R-HSA-512988 ) R-HSA-921155 Reaction Name: p-STAT5 dissociates from the receptor complex See in Reactome R-HSA-9027274 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9027274 Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-2586553 ( R-HSA-2586552 ) R-HSA-2586553 Reaction Name: JAK2 Phosphorylates LEPR See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-9006332 ( R-HSA-9006335 ) R-HSA-9006332 Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin See in Reactome R-HSA-879925 ( R-HSA-512988 ) R-HSA-879925 Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated See in Reactome R-HSA-2671855 ( R-HSA-2586552 ) R-HSA-2671855 Reaction Name: Phosphorylated LEPR Binds STAT5 See in Reactome R-HSA-1169210 ( R-HSA-982772 ) R-HSA-1169210 Reaction Name: PTP1B dephosphorylates JAK2 See in Reactome R-HSA-9027281 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027281 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-447226 ( R-HSA-9020591 ) R-HSA-447226 Reaction Name: Interleukin-12 binds Interleukin-12 receptor See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-9012654 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012654 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950583 ( R-HSA-9020933 ) R-HSA-8950583 Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9027280 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-1370505 ( R-HSA-1170546 ) R-HSA-1370505 Reaction Name: PRLR is phosphorylated at Ser-349 See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-8983876 ( R-HSA-8984722 ) R-HSA-8983876 Reaction Name: STAT4 binds IL12RB2:IL12RB2 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8950364 ( R-HSA-9020933 ) R-HSA-8950364 Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-8950128 ( R-HSA-9020591 ) R-HSA-8950128 Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor See in Reactome R-HSA-879907 ( R-HSA-512988 ) R-HSA-879907 Reaction Name: Tyrosine kinases phosphorylate the receptor See in Reactome R-HSA-1168423 ( R-HSA-982772 ) R-HSA-1168423 Reaction Name: JAK2 phosphorylation of IRS-1/2 See in Reactome R-HSA-1168768 ( R-HSA-982772 ) R-HSA-1168768 Reaction Name: JAK2 binds STAT1/3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-2671829 ( R-HSA-2586552 ) R-HSA-2671829 Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-976991 ( R-HSA-1170546 ) R-HSA-976991 Reaction Name: Prolactin receptor ligands bind the prolactin receptor See in Reactome R-HSA-1671687 ( R-HSA-1170546 ) R-HSA-1671687 Reaction Name: PRLR activation See in Reactome R-HSA-9032478 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9032478 Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-9006325 ( R-HSA-9006335 ) R-HSA-9006325 Reaction Name: EPO binds EPOR:JAK2:LYN:IRS2 See in Reactome R-HSA-9029158 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-982792 ( R-HSA-982772 ) R-HSA-982792 Reaction Name: Growth hormone receptor binds JAK2 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-9027425 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027425 Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 See in Reactome R-HSA-9024723 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024723 Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1 See in Reactome R-HSA-879930 ( R-HSA-512988 ) R-HSA-879930 Reaction Name: STAT5 is recruited by JAK2 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-1169188 ( R-HSA-982772 ) R-HSA-1169188 Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-879910 ( R-HSA-512988 ) R-HSA-879910 Reaction Name: JAK2 is phosphorylated, activated See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-2671876 ( R-HSA-2586552 ) R-HSA-2671876 Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor See in Reactome R-HSA-2671868 ( R-HSA-2586552 ) R-HSA-2671868 Reaction Name: Phosphorylated LEPR Binds STAT3 See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-879934 ( R-HSA-512988 ) R-HSA-879934 Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain See in Reactome R-HSA-6786114 ( R-HSA-6785807 ) R-HSA-6786114 Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2 See in Reactome R-HSA-913451 ( R-HSA-512988 ) R-HSA-913451 Reaction Name: IL3RB is phosphorylated on Ser-585 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-8983519 ( R-HSA-8984722 ) R-HSA-8983519 Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-913370 ( R-HSA-512988 ) R-HSA-913370 Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-2671873 ( R-HSA-2586552 ) R-HSA-2671873 Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-3215391 ( R-HSA-3214858 ) R-HSA-3215391 Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-1369080 ( R-HSA-1170546 ) R-HSA-1369080 Reaction Name: PRLR binds STAT5 See in Reactome R-HSA-1364044 ( R-HSA-1170546 ) R-HSA-1364044 Reaction Name: PRLR:JAK2 dimerizes See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-9027275 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8950269 ( R-HSA-9020933 ) R-HSA-8950269 Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor See in Reactome R-HSA-879942 ( R-HSA-512988 ) R-HSA-879942 Reaction Name: The receptor is activated See in Reactome R-HSA-8952823 ( R-HSA-9020933 ) R-HSA-8952823 Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor See in Reactome R-HSA-912757 ( R-HSA-512988 ) R-HSA-912757 Reaction Name: p-S585-IL3RB binds 14-3-3 proteins See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-2671839 ( R-HSA-2586552 ) R-HSA-2671839 Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9027273 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027273 Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-982810 ( R-HSA-1170546; R-HSA-982772 ) R-HSA-982810 Reaction Name: JAK2 phosphorylation See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8981093 ( R-HSA-9020591 ) R-HSA-8981093 Reaction Name: IL12 bound to IL12R internalises See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-1671691 ( R-HSA-1170546 ) R-HSA-1671691 Reaction Name: PRLR-bound STAT5 is phosphorylated See in Reactome R-HSA-447130 ( R-HSA-9020933 ) R-HSA-447130 Reaction Name: Interleukin-23 binds interleukin-23 receptor See in Reactome R-HSA-879937 ( R-HSA-512988 ) R-HSA-879937 Reaction Name: The common beta chain IL3RB binds JAK2 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-6785821 ( R-HSA-6785807 ) R-HSA-6785821 Reaction Name: SOCS5,(SOCS1) bind IL4RA See in Reactome R-HSA-9024726 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024726 Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-9029149 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029149 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-9006323 ( R-HSA-9006335 ) R-HSA-9006323 Reaction Name: Phospho-JAK2 phosphorylates EPOR See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-997237 ( R-HSA-983231 ) R-HSA-997237 Reaction Name: SH2B proteins bind JAK2 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-982778 ( R-HSA-982772 ) R-HSA-982778 Reaction Name: Growth hormone binds the growth hormone receptor See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-1170539 ( R-HSA-1170546 ) R-HSA-1170539 Reaction Name: Prolactin receptor is internalized See in Reactome R-HSA-9012650 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012650 Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-6786092 ( R-HSA-6785807 ) R-HSA-6786092 Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-879909 ( R-HSA-512988 ) R-HSA-879909 Reaction Name: Activation of STAT5a/b by JAK2 See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-450031 ( R-HSA-512988 ) R-HSA-450031 Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8950591 ( R-HSA-9020933 ) R-HSA-8950591 Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated See in Reactome R-HSA-9021627 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-913371 ( R-HSA-512988 ) R-HSA-913371 Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-1168894 ( R-HSA-982772 ) R-HSA-1168894 Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-2586559 ( R-HSA-2586552 ) R-HSA-2586559 Reaction Name: Leptin Binds Leptin Receptor See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-6786101 ( R-HSA-6785807 ) R-HSA-6786101 Reaction Name: IL4 binds IL4R:JAK2 See in Reactome R-HSA-1168839 ( R-HSA-982772 ) R-HSA-1168839 Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-8983878 ( R-HSA-8984722 ) R-HSA-8983878 Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-2671850 ( R-HSA-2586552 ) R-HSA-2671850 Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-1168767 ( R-HSA-982772 ) R-HSA-1168767 Reaction Name: JAK2 phosphorylates STAT1/STAT3 See in Reactome R-HSA-9029151 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029151 Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 See in Reactome R-HSA-447252 ( R-HSA-9020591 ) R-HSA-447252 Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2 See in Reactome R-HSA-1168394 ( R-HSA-982772 ) R-HSA-1168394 Reaction Name: STAT5 tyrosine phosphorylation See in Reactome R-HSA-1168393 ( R-HSA-982772 ) R-HSA-1168393 Reaction Name: STAT5 association with GHR See in Reactome R-HSA-9029155 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029155 Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-8952749 ( R-HSA-9020933 ) R-HSA-8952749 Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-1302698 ( R-HSA-1170546 ) R-HSA-1302698 Reaction Name: PRLR associates with JAK2 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-1675473 ( R-HSA-1170546 ) R-HSA-1675473 Reaction Name: SH2B binds JAK2 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1168445 ( R-HSA-982772 ) R-HSA-1168445 Reaction Name: PTP1B binds the GH receptor complex See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1364043 ( R-HSA-1170546 ) R-HSA-1364043 Reaction Name: Tyrosine phosphorylation of PRLR See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-9027373 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027373 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma See in Reactome R-HSA-8983872 ( R-HSA-8984722 ) R-HSA-8983872 Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-9029150 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029150 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-1168809 ( R-HSA-982772 ) R-HSA-1168809 Reaction Name: SOCS binding to GHR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-2671872 ( R-HSA-2586552 ) R-HSA-2671872 Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1 See in Reactome R-HSA-982807 ( R-HSA-982772 ) R-HSA-982807 Reaction Name: JAK2 phosphorylation of GHR See in Reactome R-HSA-9012657 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-982775 ( R-HSA-982772 ) R-HSA-982775 Reaction Name: Growth hormone receptor dimerizes See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-982768 ( R-HSA-982772 ) R-HSA-982768 Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change See in Reactome R-HSA-9027272 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027272 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-1168813 ( R-HSA-982772 ) R-HSA-1168813 Reaction Name: SOCS binding to JAK2 See in Reactome
MONDO:0005575	AKT1	P31749	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-450385 R-HSA-450385 Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Metabolism of RNA Vesicle-mediated transport Hemostasis	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9009391; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-432110 ( R-HSA-354192 ) R-HSA-432110 Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding See in Reactome R-HSA-450490 ( R-HSA-450385 ) R-HSA-450490 Reaction Name: Protein Kinase B/Akt phosphorylates BRF1 See in Reactome R-HSA-450499 ( R-HSA-450604 ) R-HSA-450499 Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP See in Reactome R-HSA-6790041 ( R-HSA-6785807 ) R-HSA-6790041 Reaction Name: Expression of STAT3-upregulated cytosolic proteins See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-6811504 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-6811504 Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma See in Reactome R-HSA-8848751 ( R-HSA-8849469 ) R-HSA-8848751 Reaction Name: PTK6 binds AKT1 See in Reactome R-HSA-8848758 ( R-HSA-8849469 ) R-HSA-8848758 Reaction Name: PTK6 phosphorylates AKT1 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9604328 ( R-HSA-9604323 ) R-HSA-9604328 Reaction Name: AKT1 phosphorylates NOTCH4 See in Reactome R-HSA-9624526 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0007572	JAK2	O60674	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-9027277 R-HSA-9027277 Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG) See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-9027283 R-HSA-9027283 Reactome Name: Erythropoietin activates STAT5 See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-3214858 R-HSA-3214858 Reactome Name: RMTs methylate histone arginines See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Chromatin organization Cell Cycle Hemostasis Signal Transduction	R-HSA-1168456 ( R-HSA-982772 ) R-HSA-1168456 Reaction Name: Growth hormone receptor binds Lyn See in Reactome R-HSA-8983870 ( R-HSA-8984722 ) R-HSA-8983870 Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated See in Reactome R-HSA-2671862 ( R-HSA-2586552 ) R-HSA-2671862 Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin See in Reactome R-HSA-6786070 ( R-HSA-6785807 ) R-HSA-6786070 Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950737 ( R-HSA-9020933 ) R-HSA-8950737 Reaction Name: IL23R binds JAK2 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8950423 ( R-HSA-9020591 ) R-HSA-8950423 Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-2586555 ( R-HSA-2586552 ) R-HSA-2586555 Reaction Name: JAK2 Autophosphorylates in Response to Leptin See in Reactome R-HSA-1370500 ( R-HSA-1170546 ) R-HSA-1370500 Reaction Name: PRLR binds SCF beta-TrCP complex See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-1169192 ( R-HSA-982772 ) R-HSA-1169192 Reaction Name: PTP1B dephosphorylates GHR See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-9012651 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012651 Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-6785898 ( R-HSA-6785807 ) R-HSA-6785898 Reaction Name: IL4R binds JAK2 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-2672302 ( R-HSA-2586552 ) R-HSA-2672302 Reaction Name: Phosphorylated LEPR Binds SOCS3 See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-8950063 ( R-HSA-9020591 ) R-HSA-8950063 Reaction Name: IL12RB2 binds JAK2 See in Reactome R-HSA-921155 ( R-HSA-512988 ) R-HSA-921155 Reaction Name: p-STAT5 dissociates from the receptor complex See in Reactome R-HSA-9027274 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9027274 Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-2586553 ( R-HSA-2586552 ) R-HSA-2586553 Reaction Name: JAK2 Phosphorylates LEPR See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-9006332 ( R-HSA-9006335 ) R-HSA-9006332 Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin See in Reactome R-HSA-879925 ( R-HSA-512988 ) R-HSA-879925 Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated See in Reactome R-HSA-2671855 ( R-HSA-2586552 ) R-HSA-2671855 Reaction Name: Phosphorylated LEPR Binds STAT5 See in Reactome R-HSA-1169210 ( R-HSA-982772 ) R-HSA-1169210 Reaction Name: PTP1B dephosphorylates JAK2 See in Reactome R-HSA-9027281 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027281 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-447226 ( R-HSA-9020591 ) R-HSA-447226 Reaction Name: Interleukin-12 binds Interleukin-12 receptor See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-9012654 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012654 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950583 ( R-HSA-9020933 ) R-HSA-8950583 Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9027280 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-1370505 ( R-HSA-1170546 ) R-HSA-1370505 Reaction Name: PRLR is phosphorylated at Ser-349 See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-8983876 ( R-HSA-8984722 ) R-HSA-8983876 Reaction Name: STAT4 binds IL12RB2:IL12RB2 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8950364 ( R-HSA-9020933 ) R-HSA-8950364 Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-8950128 ( R-HSA-9020591 ) R-HSA-8950128 Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor See in Reactome R-HSA-879907 ( R-HSA-512988 ) R-HSA-879907 Reaction Name: Tyrosine kinases phosphorylate the receptor See in Reactome R-HSA-1168423 ( R-HSA-982772 ) R-HSA-1168423 Reaction Name: JAK2 phosphorylation of IRS-1/2 See in Reactome R-HSA-1168768 ( R-HSA-982772 ) R-HSA-1168768 Reaction Name: JAK2 binds STAT1/3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-2671829 ( R-HSA-2586552 ) R-HSA-2671829 Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-976991 ( R-HSA-1170546 ) R-HSA-976991 Reaction Name: Prolactin receptor ligands bind the prolactin receptor See in Reactome R-HSA-1671687 ( R-HSA-1170546 ) R-HSA-1671687 Reaction Name: PRLR activation See in Reactome R-HSA-9032478 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9032478 Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-9006325 ( R-HSA-9006335 ) R-HSA-9006325 Reaction Name: EPO binds EPOR:JAK2:LYN:IRS2 See in Reactome R-HSA-9029158 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-982792 ( R-HSA-982772 ) R-HSA-982792 Reaction Name: Growth hormone receptor binds JAK2 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-9027425 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027425 Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 See in Reactome R-HSA-9024723 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024723 Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1 See in Reactome R-HSA-879930 ( R-HSA-512988 ) R-HSA-879930 Reaction Name: STAT5 is recruited by JAK2 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-1169188 ( R-HSA-982772 ) R-HSA-1169188 Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-879910 ( R-HSA-512988 ) R-HSA-879910 Reaction Name: JAK2 is phosphorylated, activated See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-2671876 ( R-HSA-2586552 ) R-HSA-2671876 Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor See in Reactome R-HSA-2671868 ( R-HSA-2586552 ) R-HSA-2671868 Reaction Name: Phosphorylated LEPR Binds STAT3 See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-879934 ( R-HSA-512988 ) R-HSA-879934 Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain See in Reactome R-HSA-6786114 ( R-HSA-6785807 ) R-HSA-6786114 Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2 See in Reactome R-HSA-913451 ( R-HSA-512988 ) R-HSA-913451 Reaction Name: IL3RB is phosphorylated on Ser-585 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-8983519 ( R-HSA-8984722 ) R-HSA-8983519 Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-913370 ( R-HSA-512988 ) R-HSA-913370 Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-2671873 ( R-HSA-2586552 ) R-HSA-2671873 Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-3215391 ( R-HSA-3214858 ) R-HSA-3215391 Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-1369080 ( R-HSA-1170546 ) R-HSA-1369080 Reaction Name: PRLR binds STAT5 See in Reactome R-HSA-1364044 ( R-HSA-1170546 ) R-HSA-1364044 Reaction Name: PRLR:JAK2 dimerizes See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-9027275 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8950269 ( R-HSA-9020933 ) R-HSA-8950269 Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor See in Reactome R-HSA-879942 ( R-HSA-512988 ) R-HSA-879942 Reaction Name: The receptor is activated See in Reactome R-HSA-8952823 ( R-HSA-9020933 ) R-HSA-8952823 Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor See in Reactome R-HSA-912757 ( R-HSA-512988 ) R-HSA-912757 Reaction Name: p-S585-IL3RB binds 14-3-3 proteins See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-2671839 ( R-HSA-2586552 ) R-HSA-2671839 Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9027273 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027273 Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-982810 ( R-HSA-1170546; R-HSA-982772 ) R-HSA-982810 Reaction Name: JAK2 phosphorylation See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8981093 ( R-HSA-9020591 ) R-HSA-8981093 Reaction Name: IL12 bound to IL12R internalises See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-1671691 ( R-HSA-1170546 ) R-HSA-1671691 Reaction Name: PRLR-bound STAT5 is phosphorylated See in Reactome R-HSA-447130 ( R-HSA-9020933 ) R-HSA-447130 Reaction Name: Interleukin-23 binds interleukin-23 receptor See in Reactome R-HSA-879937 ( R-HSA-512988 ) R-HSA-879937 Reaction Name: The common beta chain IL3RB binds JAK2 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-6785821 ( R-HSA-6785807 ) R-HSA-6785821 Reaction Name: SOCS5,(SOCS1) bind IL4RA See in Reactome R-HSA-9024726 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024726 Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-9029149 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029149 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-9006323 ( R-HSA-9006335 ) R-HSA-9006323 Reaction Name: Phospho-JAK2 phosphorylates EPOR See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-997237 ( R-HSA-983231 ) R-HSA-997237 Reaction Name: SH2B proteins bind JAK2 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-982778 ( R-HSA-982772 ) R-HSA-982778 Reaction Name: Growth hormone binds the growth hormone receptor See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-1170539 ( R-HSA-1170546 ) R-HSA-1170539 Reaction Name: Prolactin receptor is internalized See in Reactome R-HSA-9012650 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012650 Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-6786092 ( R-HSA-6785807 ) R-HSA-6786092 Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-879909 ( R-HSA-512988 ) R-HSA-879909 Reaction Name: Activation of STAT5a/b by JAK2 See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-450031 ( R-HSA-512988 ) R-HSA-450031 Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8950591 ( R-HSA-9020933 ) R-HSA-8950591 Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated See in Reactome R-HSA-9021627 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-913371 ( R-HSA-512988 ) R-HSA-913371 Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-1168894 ( R-HSA-982772 ) R-HSA-1168894 Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-2586559 ( R-HSA-2586552 ) R-HSA-2586559 Reaction Name: Leptin Binds Leptin Receptor See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-6786101 ( R-HSA-6785807 ) R-HSA-6786101 Reaction Name: IL4 binds IL4R:JAK2 See in Reactome R-HSA-1168839 ( R-HSA-982772 ) R-HSA-1168839 Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-8983878 ( R-HSA-8984722 ) R-HSA-8983878 Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-2671850 ( R-HSA-2586552 ) R-HSA-2671850 Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-1168767 ( R-HSA-982772 ) R-HSA-1168767 Reaction Name: JAK2 phosphorylates STAT1/STAT3 See in Reactome R-HSA-9029151 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029151 Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 See in Reactome R-HSA-447252 ( R-HSA-9020591 ) R-HSA-447252 Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2 See in Reactome R-HSA-1168394 ( R-HSA-982772 ) R-HSA-1168394 Reaction Name: STAT5 tyrosine phosphorylation See in Reactome R-HSA-1168393 ( R-HSA-982772 ) R-HSA-1168393 Reaction Name: STAT5 association with GHR See in Reactome R-HSA-9029155 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029155 Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-8952749 ( R-HSA-9020933 ) R-HSA-8952749 Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-1302698 ( R-HSA-1170546 ) R-HSA-1302698 Reaction Name: PRLR associates with JAK2 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-1675473 ( R-HSA-1170546 ) R-HSA-1675473 Reaction Name: SH2B binds JAK2 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1168445 ( R-HSA-982772 ) R-HSA-1168445 Reaction Name: PTP1B binds the GH receptor complex See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1364043 ( R-HSA-1170546 ) R-HSA-1364043 Reaction Name: Tyrosine phosphorylation of PRLR See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-9027373 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027373 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma See in Reactome R-HSA-8983872 ( R-HSA-8984722 ) R-HSA-8983872 Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-9029150 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029150 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-1168809 ( R-HSA-982772 ) R-HSA-1168809 Reaction Name: SOCS binding to GHR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-2671872 ( R-HSA-2586552 ) R-HSA-2671872 Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1 See in Reactome R-HSA-982807 ( R-HSA-982772 ) R-HSA-982807 Reaction Name: JAK2 phosphorylation of GHR See in Reactome R-HSA-9012657 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-982775 ( R-HSA-982772 ) R-HSA-982775 Reaction Name: Growth hormone receptor dimerizes See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-982768 ( R-HSA-982772 ) R-HSA-982768 Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change See in Reactome R-HSA-9027272 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027272 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-1168813 ( R-HSA-982772 ) R-HSA-1168813 Reaction Name: SOCS binding to JAK2 See in Reactome
MONDO:0008170	AKT1	P31749	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-450385 R-HSA-450385 Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Metabolism of RNA Vesicle-mediated transport Hemostasis	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9009391; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-432110 ( R-HSA-354192 ) R-HSA-432110 Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding See in Reactome R-HSA-450490 ( R-HSA-450385 ) R-HSA-450490 Reaction Name: Protein Kinase B/Akt phosphorylates BRF1 See in Reactome R-HSA-450499 ( R-HSA-450604 ) R-HSA-450499 Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP See in Reactome R-HSA-6790041 ( R-HSA-6785807 ) R-HSA-6790041 Reaction Name: Expression of STAT3-upregulated cytosolic proteins See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-6811504 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-6811504 Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma See in Reactome R-HSA-8848751 ( R-HSA-8849469 ) R-HSA-8848751 Reaction Name: PTK6 binds AKT1 See in Reactome R-HSA-8848758 ( R-HSA-8849469 ) R-HSA-8848758 Reaction Name: PTK6 phosphorylates AKT1 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9604328 ( R-HSA-9604323 ) R-HSA-9604328 Reaction Name: AKT1 phosphorylates NOTCH4 See in Reactome R-HSA-9624526 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0008318	AKT1	P31749	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-450385 R-HSA-450385 Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Metabolism of RNA Vesicle-mediated transport Hemostasis	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9009391; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-432110 ( R-HSA-354192 ) R-HSA-432110 Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding See in Reactome R-HSA-450490 ( R-HSA-450385 ) R-HSA-450490 Reaction Name: Protein Kinase B/Akt phosphorylates BRF1 See in Reactome R-HSA-450499 ( R-HSA-450604 ) R-HSA-450499 Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP See in Reactome R-HSA-6790041 ( R-HSA-6785807 ) R-HSA-6790041 Reaction Name: Expression of STAT3-upregulated cytosolic proteins See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-6811504 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-6811504 Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma See in Reactome R-HSA-8848751 ( R-HSA-8849469 ) R-HSA-8848751 Reaction Name: PTK6 binds AKT1 See in Reactome R-HSA-8848758 ( R-HSA-8849469 ) R-HSA-8848758 Reaction Name: PTK6 phosphorylates AKT1 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9604328 ( R-HSA-9604323 ) R-HSA-9604328 Reaction Name: AKT1 phosphorylates NOTCH4 See in Reactome R-HSA-9624526 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0009539	JAK1	P23458	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-1169408 R-HSA-1169408 Reactome Name: ISG15 antiviral mechanism See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020958 R-HSA-9020958 Reactome Name: Interleukin-21 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-1266695 R-HSA-1266695 Reactome Name: Interleukin-7 signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-8985947 R-HSA-8985947 Reactome Name: Interleukin-9 signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-8983432 R-HSA-8983432 Reactome Name: Interleukin-15 signaling See in Reactome R-HSA-6783783 R-HSA-6783783 Reactome Name: Interleukin-10 signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-449836 R-HSA-449836 Reactome Name: Other interleukin signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-1169410 R-HSA-1169410 Reactome Name: Antiviral mechanism by IFN-stimulated genes See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Signal Transduction	R-HSA-9677585 ( R-HSA-9674555 ) R-HSA-9677585 Reaction Name: CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 See in Reactome R-HSA-909720 ( R-HSA-909733 ) R-HSA-909720 Reaction Name: IFN alpha/beta binds to IFNAR2 See in Reactome R-HSA-8987266 ( R-HSA-8854691 ) R-HSA-8987266 Reaction Name: IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 See in Reactome R-HSA-448708 ( R-HSA-8854691 ) R-HSA-448708 Reaction Name: IL24 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-8983335 ( R-HSA-8983432 ) R-HSA-8983335 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome See in Reactome R-HSA-8985988 ( R-HSA-8985947 ) R-HSA-8985988 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-6784319 ( R-HSA-6783783 ) R-HSA-6784319 Reaction Name: JAK1,TYK2 phosphorylate JAK1,TYK2 See in Reactome R-HSA-8987105 ( R-HSA-8854691 ) R-HSA-8987105 Reaction Name: IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-451900 ( R-HSA-9020558 ) R-HSA-451900 Reaction Name: IL2RB binds JAK1 See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-8987015 ( R-HSA-8854691 ) R-HSA-8987015 Reaction Name: IL20 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-452091 ( R-HSA-9020558 ) R-HSA-452091 Reaction Name: Phosphorylation of IL2RB Y338 enables SHC recruitment See in Reactome R-HSA-8854645 ( R-HSA-8854691 ) R-HSA-8854645 Reaction Name: IL22:IL22RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-9006873 ( R-HSA-9020958 ) R-HSA-9006873 Reaction Name: IL21 receptor STAT binding See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-9025969 ( R-HSA-1266695 ) R-HSA-9025969 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 See in Reactome R-HSA-9005980 ( R-HSA-9020958 ) R-HSA-9005980 Reaction Name: IL21 binds IL21R:JAK1 See in Reactome R-HSA-912680 ( R-HSA-909733; R-HSA-912694 ) R-HSA-912680 Reaction Name: Inhibition of JAK kinase activity by SOCS1/3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-448661 ( R-HSA-449836; R-HSA-8854691 ) R-HSA-448661 Reaction Name: IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-449811 ( R-HSA-6783783 ) R-HSA-449811 Reaction Name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-8987270 ( R-HSA-8854691 ) R-HSA-8987270 Reaction Name: p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9674558 ( R-HSA-9674555 ) R-HSA-9674558 Reaction Name: p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 See in Reactome R-HSA-8982165 ( R-HSA-8854691 ) R-HSA-8982165 Reaction Name: IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 See in Reactome R-HSA-9678935 ( R-HSA-909733 ) R-HSA-9678935 Reaction Name: IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors See in Reactome R-HSA-8983374 ( R-HSA-8983432 ) R-HSA-8983374 Reaction Name: p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 See in Reactome R-HSA-8987080 ( R-HSA-8854691 ) R-HSA-8987080 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8987039 ( R-HSA-8854691 ) R-HSA-8987039 Reaction Name: JAK1 binds IL20RA See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-8986480 ( R-HSA-8854691 ) R-HSA-8986480 Reaction Name: IL26:IL20RA:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-8985929 ( R-HSA-8985947 ) R-HSA-8985929 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-452100 ( R-HSA-9020558 ) R-HSA-452100 Reaction Name: SHC1 bound to IL2 receptor is phosphorylated See in Reactome R-HSA-8983425 ( R-HSA-8983432 ) R-HSA-8983425 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 See in Reactome R-HSA-6784791 ( R-HSA-6783783 ) R-HSA-6784791 Reaction Name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8987040 ( R-HSA-8854691 ) R-HSA-8987040 Reaction Name: IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 See in Reactome R-HSA-909718 ( R-HSA-909733 ) R-HSA-909718 Reaction Name: Formation of p-STAT1 homodimer See in Reactome R-HSA-449803 ( R-HSA-6783783 ) R-HSA-449803 Reaction Name: IL10 dimer binds IL10RA:JAK1 See in Reactome R-HSA-8987161 ( R-HSA-8854691 ) R-HSA-8987161 Reaction Name: p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 See in Reactome R-HSA-8987129 ( R-HSA-8854691 ) R-HSA-8987129 Reaction Name: JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-6784006 ( R-HSA-6783783 ) R-HSA-6784006 Reaction Name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 See in Reactome R-HSA-452108 ( R-HSA-9020558 ) R-HSA-452108 Reaction Name: Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-909729 ( R-HSA-909733 ) R-HSA-909729 Reaction Name: Activation of JAK kinases See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-8983371 ( R-HSA-8983432 ) R-HSA-8983371 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome R-HSA-997314 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997314 Reaction Name: Dephosphorylation of JAK1 by SHP1 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-6784324 ( R-HSA-6783783 ) R-HSA-6784324 Reaction Name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA See in Reactome R-HSA-450063 ( R-HSA-9020558 ) R-HSA-450063 Reaction Name: Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit See in Reactome R-HSA-8982162 ( R-HSA-8854691 ) R-HSA-8982162 Reaction Name: p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB See in Reactome R-HSA-8963734 ( R-HSA-8985947 ) R-HSA-8963734 Reaction Name: IL9 binds IL9R:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-1169406 ( R-HSA-1169408 ) R-HSA-1169406 Reaction Name: ISGylation of host proteins See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-8987120 ( R-HSA-8854691 ) R-HSA-8987120 Reaction Name: JAK1 binds IFNLR1 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-452097 ( R-HSA-9020558 ) R-HSA-452097 Reaction Name: Recruited STAT5 is phosphorylated See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8983298 ( R-HSA-8983432 ) R-HSA-8983298 Reaction Name: IL15 binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-448480 ( R-HSA-8854691 ) R-HSA-448480 Reaction Name: IL22 binds IL22RA1:JAK1 receptor complex See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-909730 ( R-HSA-909733 ) R-HSA-909730 Reaction Name: Phosphorylation of INFAR1 by TYK2 See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-919404 ( R-HSA-9020558 ) R-HSA-919404 Reaction Name: Phosphorylated STAT5 is released See in Reactome R-HSA-8986972 ( R-HSA-8854691 ) R-HSA-8986972 Reaction Name: IL24 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8983424 ( R-HSA-8983432 ) R-HSA-8983424 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-9009700 ( R-HSA-8983432 ) R-HSA-9009700 Reaction Name: IL2RB and IL2RG are phosphorylated See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-8983394 ( R-HSA-8983432 ) R-HSA-8983394 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 See in Reactome R-HSA-9677579 ( R-HSA-9674555 ) R-HSA-9677579 Reaction Name: CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN See in Reactome R-HSA-8986994 ( R-HSA-8854691 ) R-HSA-8986994 Reaction Name: IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-449958 ( R-HSA-1266695 ) R-HSA-449958 Reaction Name: IL7:IL7R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-8950716 ( R-HSA-9020956 ) R-HSA-8950716 Reaction Name: IL27RA binds JAK1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-1264832 ( R-HSA-1266695 ) R-HSA-1264832 Reaction Name: JAK1 binds IL7R See in Reactome R-HSA-8987202 ( R-HSA-8854691 ) R-HSA-8987202 Reaction Name: IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-909724 ( R-HSA-909733 ) R-HSA-909724 Reaction Name: Recruitment of IFNAR1 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-8987097 ( R-HSA-8854691 ) R-HSA-8987097 Reaction Name: IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 See in Reactome R-HSA-997311 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997311 Reaction Name: Dephosphorylation of TYK2 by PTP1B See in Reactome R-HSA-8987042 ( R-HSA-8854691 ) R-HSA-8987042 Reaction Name: IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-448744 ( R-HSA-8854691 ) R-HSA-448744 Reaction Name: IL20RA binds IL20RB See in Reactome R-HSA-8986446 ( R-HSA-8854691 ) R-HSA-8986446 Reaction Name: IL26 binds IL20RA:JAK1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-8985900 ( R-HSA-8985947 ) R-HSA-8985900 Reaction Name: p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 See in Reactome R-HSA-1678841 ( R-HSA-1169408 ) R-HSA-1678841 Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-8987012 ( R-HSA-8854691 ) R-HSA-8987012 Reaction Name: IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-909719 ( R-HSA-909733 ) R-HSA-909719 Reaction Name: Recruitment of STAT2 to p-IFNAR1 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-9006844 ( R-HSA-9020958 ) R-HSA-9006844 Reaction Name: IL21:IL21R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-909732 ( R-HSA-909733 ) R-HSA-909732 Reaction Name: Phosphorylation of STAT2 See in Reactome R-HSA-9009227 ( R-HSA-8854691 ) R-HSA-9009227 Reaction Name: IL20 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-6785165 ( R-HSA-1266695 ) R-HSA-6785165 Reaction Name: p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-1295540 ( R-HSA-1266695 ) R-HSA-1295540 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-8983063 ( R-HSA-1266695 ) R-HSA-8983063 Reaction Name: JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated See in Reactome R-HSA-8982163 ( R-HSA-8854691 ) R-HSA-8982163 Reaction Name: IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-450027 ( R-HSA-9020558 ) R-HSA-450027 Reaction Name: Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-8987255 ( R-HSA-8854691 ) R-HSA-8987255 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 See in Reactome R-HSA-1295519 ( R-HSA-1266695 ) R-HSA-1295519 Reaction Name: IL7R is phosphorylated on Y499 See in Reactome R-HSA-448728 ( R-HSA-8854691 ) R-HSA-448728 Reaction Name: IL19 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8987084 ( R-HSA-8854691 ) R-HSA-8987084 Reaction Name: IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-8983003 ( R-HSA-1266695 ) R-HSA-8983003 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 See in Reactome R-HSA-449978 ( R-HSA-1266695 ) R-HSA-449978 Reaction Name: IL7 binds IL7R:JAK1 See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9011748 ( R-HSA-8985947 ) R-HSA-9011748 Reaction Name: IL9R binds JAK1 See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-6784323 ( R-HSA-6783783 ) R-HSA-6784323 Reaction Name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-449115 ( R-HSA-8983432 ) R-HSA-449115 Reaction Name: IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987063 ( R-HSA-8854691 ) R-HSA-8987063 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 See in Reactome R-HSA-8987043 ( R-HSA-8854691 ) R-HSA-8987043 Reaction Name: IL22RA1 binds JAK1 See in Reactome R-HSA-8983384 ( R-HSA-8983432 ) R-HSA-8983384 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-9006850 ( R-HSA-9020958 ) R-HSA-9006850 Reaction Name: IL21 receptor JAK phosphorylation See in Reactome R-HSA-8987150 ( R-HSA-8854691 ) R-HSA-8987150 Reaction Name: IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-8983300 ( R-HSA-8983432 ) R-HSA-8983300 Reaction Name: IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-8987096 ( R-HSA-8854691 ) R-HSA-8987096 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-8986995 ( R-HSA-8854691 ) R-HSA-8986995 Reaction Name: IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA See in Reactome R-HSA-8986985 ( R-HSA-8854691 ) R-HSA-8986985 Reaction Name: IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-452122 ( R-HSA-9020558 ) R-HSA-452122 Reaction Name: JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB See in Reactome R-HSA-909722 ( R-HSA-909733 ) R-HSA-909722 Reaction Name: Release of p-STAT2:p-STAT1 dimer See in Reactome R-HSA-8987033 ( R-HSA-8854691 ) R-HSA-8987033 Reaction Name: p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-8983309 ( R-HSA-8983432 ) R-HSA-8983309 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 See in Reactome R-HSA-448660 ( R-HSA-6788467 ) R-HSA-448660 Reaction Name: IL31:IL31RA:JAK1 binds OSMR:JAK1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-8985973 ( R-HSA-8985947 ) R-HSA-8985973 Reaction Name: IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 See in Reactome R-HSA-451942 ( R-HSA-9020558 ) R-HSA-451942 Reaction Name: Within the IL-2R complex JAK3 phosphorylates JAK1 See in Reactome R-HSA-9006870 ( R-HSA-9020958 ) R-HSA-9006870 Reaction Name: IL21 receptor STAT phosphorylation See in Reactome R-HSA-8985914 ( R-HSA-8985947 ) R-HSA-8985914 Reaction Name: IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-8983299 ( R-HSA-8983432 ) R-HSA-8983299 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-8983378 ( R-HSA-8983432 ) R-HSA-8983378 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-8987230 ( R-HSA-8854691 ) R-HSA-8987230 Reaction Name: p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1295516 ( R-HSA-1266695 ) R-HSA-1295516 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-9674546 ( R-HSA-9674555 ) R-HSA-9674546 Reaction Name: CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1 See in Reactome
MONDO:0009692	JAK2	O60674	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-9027277 R-HSA-9027277 Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG) See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-9027283 R-HSA-9027283 Reactome Name: Erythropoietin activates STAT5 See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-3214858 R-HSA-3214858 Reactome Name: RMTs methylate histone arginines See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Chromatin organization Cell Cycle Hemostasis Signal Transduction	R-HSA-1168456 ( R-HSA-982772 ) R-HSA-1168456 Reaction Name: Growth hormone receptor binds Lyn See in Reactome R-HSA-8983870 ( R-HSA-8984722 ) R-HSA-8983870 Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated See in Reactome R-HSA-2671862 ( R-HSA-2586552 ) R-HSA-2671862 Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin See in Reactome R-HSA-6786070 ( R-HSA-6785807 ) R-HSA-6786070 Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950737 ( R-HSA-9020933 ) R-HSA-8950737 Reaction Name: IL23R binds JAK2 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8950423 ( R-HSA-9020591 ) R-HSA-8950423 Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-2586555 ( R-HSA-2586552 ) R-HSA-2586555 Reaction Name: JAK2 Autophosphorylates in Response to Leptin See in Reactome R-HSA-1370500 ( R-HSA-1170546 ) R-HSA-1370500 Reaction Name: PRLR binds SCF beta-TrCP complex See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-1169192 ( R-HSA-982772 ) R-HSA-1169192 Reaction Name: PTP1B dephosphorylates GHR See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-9012651 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012651 Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-6785898 ( R-HSA-6785807 ) R-HSA-6785898 Reaction Name: IL4R binds JAK2 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-2672302 ( R-HSA-2586552 ) R-HSA-2672302 Reaction Name: Phosphorylated LEPR Binds SOCS3 See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-8950063 ( R-HSA-9020591 ) R-HSA-8950063 Reaction Name: IL12RB2 binds JAK2 See in Reactome R-HSA-921155 ( R-HSA-512988 ) R-HSA-921155 Reaction Name: p-STAT5 dissociates from the receptor complex See in Reactome R-HSA-9027274 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9027274 Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-2586553 ( R-HSA-2586552 ) R-HSA-2586553 Reaction Name: JAK2 Phosphorylates LEPR See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-9006332 ( R-HSA-9006335 ) R-HSA-9006332 Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin See in Reactome R-HSA-879925 ( R-HSA-512988 ) R-HSA-879925 Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated See in Reactome R-HSA-2671855 ( R-HSA-2586552 ) R-HSA-2671855 Reaction Name: Phosphorylated LEPR Binds STAT5 See in Reactome R-HSA-1169210 ( R-HSA-982772 ) R-HSA-1169210 Reaction Name: PTP1B dephosphorylates JAK2 See in Reactome R-HSA-9027281 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027281 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-447226 ( R-HSA-9020591 ) R-HSA-447226 Reaction Name: Interleukin-12 binds Interleukin-12 receptor See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-9012654 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012654 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950583 ( R-HSA-9020933 ) R-HSA-8950583 Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9027280 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-1370505 ( R-HSA-1170546 ) R-HSA-1370505 Reaction Name: PRLR is phosphorylated at Ser-349 See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-8983876 ( R-HSA-8984722 ) R-HSA-8983876 Reaction Name: STAT4 binds IL12RB2:IL12RB2 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8950364 ( R-HSA-9020933 ) R-HSA-8950364 Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-8950128 ( R-HSA-9020591 ) R-HSA-8950128 Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor See in Reactome R-HSA-879907 ( R-HSA-512988 ) R-HSA-879907 Reaction Name: Tyrosine kinases phosphorylate the receptor See in Reactome R-HSA-1168423 ( R-HSA-982772 ) R-HSA-1168423 Reaction Name: JAK2 phosphorylation of IRS-1/2 See in Reactome R-HSA-1168768 ( R-HSA-982772 ) R-HSA-1168768 Reaction Name: JAK2 binds STAT1/3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-2671829 ( R-HSA-2586552 ) R-HSA-2671829 Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-976991 ( R-HSA-1170546 ) R-HSA-976991 Reaction Name: Prolactin receptor ligands bind the prolactin receptor See in Reactome R-HSA-1671687 ( R-HSA-1170546 ) R-HSA-1671687 Reaction Name: PRLR activation See in Reactome R-HSA-9032478 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9032478 Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-9006325 ( R-HSA-9006335 ) R-HSA-9006325 Reaction Name: EPO binds EPOR:JAK2:LYN:IRS2 See in Reactome R-HSA-9029158 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-982792 ( R-HSA-982772 ) R-HSA-982792 Reaction Name: Growth hormone receptor binds JAK2 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-9027425 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027425 Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 See in Reactome R-HSA-9024723 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024723 Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1 See in Reactome R-HSA-879930 ( R-HSA-512988 ) R-HSA-879930 Reaction Name: STAT5 is recruited by JAK2 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-1169188 ( R-HSA-982772 ) R-HSA-1169188 Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-879910 ( R-HSA-512988 ) R-HSA-879910 Reaction Name: JAK2 is phosphorylated, activated See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-2671876 ( R-HSA-2586552 ) R-HSA-2671876 Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor See in Reactome R-HSA-2671868 ( R-HSA-2586552 ) R-HSA-2671868 Reaction Name: Phosphorylated LEPR Binds STAT3 See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-879934 ( R-HSA-512988 ) R-HSA-879934 Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain See in Reactome R-HSA-6786114 ( R-HSA-6785807 ) R-HSA-6786114 Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2 See in Reactome R-HSA-913451 ( R-HSA-512988 ) R-HSA-913451 Reaction Name: IL3RB is phosphorylated on Ser-585 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-8983519 ( R-HSA-8984722 ) R-HSA-8983519 Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-913370 ( R-HSA-512988 ) R-HSA-913370 Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-2671873 ( R-HSA-2586552 ) R-HSA-2671873 Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-3215391 ( R-HSA-3214858 ) R-HSA-3215391 Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-1369080 ( R-HSA-1170546 ) R-HSA-1369080 Reaction Name: PRLR binds STAT5 See in Reactome R-HSA-1364044 ( R-HSA-1170546 ) R-HSA-1364044 Reaction Name: PRLR:JAK2 dimerizes See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-9027275 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8950269 ( R-HSA-9020933 ) R-HSA-8950269 Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor See in Reactome R-HSA-879942 ( R-HSA-512988 ) R-HSA-879942 Reaction Name: The receptor is activated See in Reactome R-HSA-8952823 ( R-HSA-9020933 ) R-HSA-8952823 Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor See in Reactome R-HSA-912757 ( R-HSA-512988 ) R-HSA-912757 Reaction Name: p-S585-IL3RB binds 14-3-3 proteins See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-2671839 ( R-HSA-2586552 ) R-HSA-2671839 Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9027273 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027273 Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-982810 ( R-HSA-1170546; R-HSA-982772 ) R-HSA-982810 Reaction Name: JAK2 phosphorylation See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8981093 ( R-HSA-9020591 ) R-HSA-8981093 Reaction Name: IL12 bound to IL12R internalises See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-1671691 ( R-HSA-1170546 ) R-HSA-1671691 Reaction Name: PRLR-bound STAT5 is phosphorylated See in Reactome R-HSA-447130 ( R-HSA-9020933 ) R-HSA-447130 Reaction Name: Interleukin-23 binds interleukin-23 receptor See in Reactome R-HSA-879937 ( R-HSA-512988 ) R-HSA-879937 Reaction Name: The common beta chain IL3RB binds JAK2 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-6785821 ( R-HSA-6785807 ) R-HSA-6785821 Reaction Name: SOCS5,(SOCS1) bind IL4RA See in Reactome R-HSA-9024726 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024726 Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-9029149 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029149 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-9006323 ( R-HSA-9006335 ) R-HSA-9006323 Reaction Name: Phospho-JAK2 phosphorylates EPOR See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-997237 ( R-HSA-983231 ) R-HSA-997237 Reaction Name: SH2B proteins bind JAK2 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-982778 ( R-HSA-982772 ) R-HSA-982778 Reaction Name: Growth hormone binds the growth hormone receptor See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-1170539 ( R-HSA-1170546 ) R-HSA-1170539 Reaction Name: Prolactin receptor is internalized See in Reactome R-HSA-9012650 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012650 Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-6786092 ( R-HSA-6785807 ) R-HSA-6786092 Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-879909 ( R-HSA-512988 ) R-HSA-879909 Reaction Name: Activation of STAT5a/b by JAK2 See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-450031 ( R-HSA-512988 ) R-HSA-450031 Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8950591 ( R-HSA-9020933 ) R-HSA-8950591 Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated See in Reactome R-HSA-9021627 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-913371 ( R-HSA-512988 ) R-HSA-913371 Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-1168894 ( R-HSA-982772 ) R-HSA-1168894 Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-2586559 ( R-HSA-2586552 ) R-HSA-2586559 Reaction Name: Leptin Binds Leptin Receptor See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-6786101 ( R-HSA-6785807 ) R-HSA-6786101 Reaction Name: IL4 binds IL4R:JAK2 See in Reactome R-HSA-1168839 ( R-HSA-982772 ) R-HSA-1168839 Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-8983878 ( R-HSA-8984722 ) R-HSA-8983878 Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-2671850 ( R-HSA-2586552 ) R-HSA-2671850 Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-1168767 ( R-HSA-982772 ) R-HSA-1168767 Reaction Name: JAK2 phosphorylates STAT1/STAT3 See in Reactome R-HSA-9029151 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029151 Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 See in Reactome R-HSA-447252 ( R-HSA-9020591 ) R-HSA-447252 Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2 See in Reactome R-HSA-1168394 ( R-HSA-982772 ) R-HSA-1168394 Reaction Name: STAT5 tyrosine phosphorylation See in Reactome R-HSA-1168393 ( R-HSA-982772 ) R-HSA-1168393 Reaction Name: STAT5 association with GHR See in Reactome R-HSA-9029155 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029155 Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-8952749 ( R-HSA-9020933 ) R-HSA-8952749 Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-1302698 ( R-HSA-1170546 ) R-HSA-1302698 Reaction Name: PRLR associates with JAK2 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-1675473 ( R-HSA-1170546 ) R-HSA-1675473 Reaction Name: SH2B binds JAK2 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1168445 ( R-HSA-982772 ) R-HSA-1168445 Reaction Name: PTP1B binds the GH receptor complex See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1364043 ( R-HSA-1170546 ) R-HSA-1364043 Reaction Name: Tyrosine phosphorylation of PRLR See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-9027373 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027373 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma See in Reactome R-HSA-8983872 ( R-HSA-8984722 ) R-HSA-8983872 Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-9029150 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029150 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-1168809 ( R-HSA-982772 ) R-HSA-1168809 Reaction Name: SOCS binding to GHR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-2671872 ( R-HSA-2586552 ) R-HSA-2671872 Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1 See in Reactome R-HSA-982807 ( R-HSA-982772 ) R-HSA-982807 Reaction Name: JAK2 phosphorylation of GHR See in Reactome R-HSA-9012657 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-982775 ( R-HSA-982772 ) R-HSA-982775 Reaction Name: Growth hormone receptor dimerizes See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-982768 ( R-HSA-982772 ) R-HSA-982768 Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change See in Reactome R-HSA-9027272 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027272 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-1168813 ( R-HSA-982772 ) R-HSA-1168813 Reaction Name: SOCS binding to JAK2 See in Reactome
MONDO:0009809	MMP2	P08253	3.4.24.24	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Metabolism of proteins Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1454757 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454757 Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 See in Reactome R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1454791 ( R-HSA-1474228 ) R-HSA-1454791 Reaction Name: MMP2, MMP7, MMP9 bind CD44 See in Reactome R-HSA-1454822 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454822 Reaction Name: Collagen type I degradation by MMP1,2,8,13, PRSS2 See in Reactome R-HSA-1564112 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564112 Reaction Name: Collagen type VI degradation by MMP2,9,11 See in Reactome R-HSA-1564120 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564120 Reaction Name: Collagen type VII degradation by MMP1,2,3 See in Reactome R-HSA-1564142 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564142 Reaction Name: Collagen type IV degradation by MMP2,3,4,9,10,12 See in Reactome R-HSA-1564143 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564143 Reaction Name: Collagen type X degradation by MMP1,2 See in Reactome R-HSA-1564164 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564164 Reaction Name: Collagen type V degradation by MMP2,9,10 See in Reactome R-HSA-1564179 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564179 Reaction Name: Collagen type XI degradation by MMP1,2,3,9 See in Reactome R-HSA-1566962 ( R-HSA-1474228 ) R-HSA-1566962 Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-1592278 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592278 Reaction Name: Autocatalytic activation of proMMP2 See in Reactome R-HSA-1592297 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592297 Reaction Name: Full activation of MMP1 See in Reactome R-HSA-1592436 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592436 Reaction Name: Initial activation of proMMP9 by MMPs See in Reactome R-HSA-1604350 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604350 Reaction Name: MMP14:TIMP2 binds proMMP2 See in Reactome R-HSA-1604359 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604359 Reaction Name: Initial activation of proMMP2 by MMP1, 7 See in Reactome R-HSA-1604360 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604360 Reaction Name: Initial activation of proMMP2 by MMP14 See in Reactome R-HSA-1604368 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604368 Reaction Name: Autocatalytic activation of bound proMMP2 See in Reactome R-HSA-1604690 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604690 Reaction Name: Activation of MMP9 intermediate form by MMPs See in Reactome R-HSA-2485148 ( R-HSA-1474228 ) R-HSA-2485148 Reaction Name: Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 See in Reactome R-HSA-2534248 ( R-HSA-1474228 ) R-HSA-2534248 Reaction Name: DCN (decorin) degradation by MMP2, MMP3, MMP7 See in Reactome R-HSA-3791149 ( R-HSA-1474228 ) R-HSA-3791149 Reaction Name: Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 See in Reactome R-HSA-3791295 ( R-HSA-1474228 ) R-HSA-3791295 Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13 See in Reactome R-HSA-381435 ( R-HSA-381426 ) R-HSA-381435 Reaction Name: Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS See in Reactome R-HSA-3928657 ( R-HSA-3928665 ) R-HSA-3928657 Reaction Name: MMP2,9 cleave EPHB See in Reactome R-HSA-6789615 ( R-HSA-6785807 ) R-HSA-6789615 Reaction Name: Expression of STAT3-upregulated extracellular proteins See in Reactome R-HSA-8940554 ( R-HSA-1474228 ) R-HSA-8940554 Reaction Name: MMP2 cleaves OPTC See in Reactome R-HSA-8943959 ( R-HSA-1474228 ) R-HSA-8943959 Reaction Name: MMP2, MMP9 cleave SCUBE3 See in Reactome R-HSA-9624272 ( R-HSA-9009391 ) R-HSA-9624272 Reaction Name: MMPs cleave HB-EGF See in Reactome
MONDO:0009891	JAK2	O60674	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-9027277 R-HSA-9027277 Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG) See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-9027283 R-HSA-9027283 Reactome Name: Erythropoietin activates STAT5 See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-3214858 R-HSA-3214858 Reactome Name: RMTs methylate histone arginines See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Chromatin organization Cell Cycle Hemostasis Signal Transduction	R-HSA-1168456 ( R-HSA-982772 ) R-HSA-1168456 Reaction Name: Growth hormone receptor binds Lyn See in Reactome R-HSA-8983870 ( R-HSA-8984722 ) R-HSA-8983870 Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated See in Reactome R-HSA-2671862 ( R-HSA-2586552 ) R-HSA-2671862 Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin See in Reactome R-HSA-6786070 ( R-HSA-6785807 ) R-HSA-6786070 Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950737 ( R-HSA-9020933 ) R-HSA-8950737 Reaction Name: IL23R binds JAK2 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8950423 ( R-HSA-9020591 ) R-HSA-8950423 Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-2586555 ( R-HSA-2586552 ) R-HSA-2586555 Reaction Name: JAK2 Autophosphorylates in Response to Leptin See in Reactome R-HSA-1370500 ( R-HSA-1170546 ) R-HSA-1370500 Reaction Name: PRLR binds SCF beta-TrCP complex See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-1169192 ( R-HSA-982772 ) R-HSA-1169192 Reaction Name: PTP1B dephosphorylates GHR See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-9012651 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012651 Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-6785898 ( R-HSA-6785807 ) R-HSA-6785898 Reaction Name: IL4R binds JAK2 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-2672302 ( R-HSA-2586552 ) R-HSA-2672302 Reaction Name: Phosphorylated LEPR Binds SOCS3 See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-8950063 ( R-HSA-9020591 ) R-HSA-8950063 Reaction Name: IL12RB2 binds JAK2 See in Reactome R-HSA-921155 ( R-HSA-512988 ) R-HSA-921155 Reaction Name: p-STAT5 dissociates from the receptor complex See in Reactome R-HSA-9027274 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9027274 Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-2586553 ( R-HSA-2586552 ) R-HSA-2586553 Reaction Name: JAK2 Phosphorylates LEPR See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-9006332 ( R-HSA-9006335 ) R-HSA-9006332 Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin See in Reactome R-HSA-879925 ( R-HSA-512988 ) R-HSA-879925 Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated See in Reactome R-HSA-2671855 ( R-HSA-2586552 ) R-HSA-2671855 Reaction Name: Phosphorylated LEPR Binds STAT5 See in Reactome R-HSA-1169210 ( R-HSA-982772 ) R-HSA-1169210 Reaction Name: PTP1B dephosphorylates JAK2 See in Reactome R-HSA-9027281 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027281 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-447226 ( R-HSA-9020591 ) R-HSA-447226 Reaction Name: Interleukin-12 binds Interleukin-12 receptor See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-9012654 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012654 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950583 ( R-HSA-9020933 ) R-HSA-8950583 Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9027280 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-1370505 ( R-HSA-1170546 ) R-HSA-1370505 Reaction Name: PRLR is phosphorylated at Ser-349 See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-8983876 ( R-HSA-8984722 ) R-HSA-8983876 Reaction Name: STAT4 binds IL12RB2:IL12RB2 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8950364 ( R-HSA-9020933 ) R-HSA-8950364 Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-8950128 ( R-HSA-9020591 ) R-HSA-8950128 Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor See in Reactome R-HSA-879907 ( R-HSA-512988 ) R-HSA-879907 Reaction Name: Tyrosine kinases phosphorylate the receptor See in Reactome R-HSA-1168423 ( R-HSA-982772 ) R-HSA-1168423 Reaction Name: JAK2 phosphorylation of IRS-1/2 See in Reactome R-HSA-1168768 ( R-HSA-982772 ) R-HSA-1168768 Reaction Name: JAK2 binds STAT1/3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-2671829 ( R-HSA-2586552 ) R-HSA-2671829 Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-976991 ( R-HSA-1170546 ) R-HSA-976991 Reaction Name: Prolactin receptor ligands bind the prolactin receptor See in Reactome R-HSA-1671687 ( R-HSA-1170546 ) R-HSA-1671687 Reaction Name: PRLR activation See in Reactome R-HSA-9032478 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9032478 Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-9006325 ( R-HSA-9006335 ) R-HSA-9006325 Reaction Name: EPO binds EPOR:JAK2:LYN:IRS2 See in Reactome R-HSA-9029158 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-982792 ( R-HSA-982772 ) R-HSA-982792 Reaction Name: Growth hormone receptor binds JAK2 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-9027425 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027425 Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 See in Reactome R-HSA-9024723 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024723 Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1 See in Reactome R-HSA-879930 ( R-HSA-512988 ) R-HSA-879930 Reaction Name: STAT5 is recruited by JAK2 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-1169188 ( R-HSA-982772 ) R-HSA-1169188 Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-879910 ( R-HSA-512988 ) R-HSA-879910 Reaction Name: JAK2 is phosphorylated, activated See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-2671876 ( R-HSA-2586552 ) R-HSA-2671876 Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor See in Reactome R-HSA-2671868 ( R-HSA-2586552 ) R-HSA-2671868 Reaction Name: Phosphorylated LEPR Binds STAT3 See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-879934 ( R-HSA-512988 ) R-HSA-879934 Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain See in Reactome R-HSA-6786114 ( R-HSA-6785807 ) R-HSA-6786114 Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2 See in Reactome R-HSA-913451 ( R-HSA-512988 ) R-HSA-913451 Reaction Name: IL3RB is phosphorylated on Ser-585 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-8983519 ( R-HSA-8984722 ) R-HSA-8983519 Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-913370 ( R-HSA-512988 ) R-HSA-913370 Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-2671873 ( R-HSA-2586552 ) R-HSA-2671873 Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-3215391 ( R-HSA-3214858 ) R-HSA-3215391 Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-1369080 ( R-HSA-1170546 ) R-HSA-1369080 Reaction Name: PRLR binds STAT5 See in Reactome R-HSA-1364044 ( R-HSA-1170546 ) R-HSA-1364044 Reaction Name: PRLR:JAK2 dimerizes See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-9027275 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8950269 ( R-HSA-9020933 ) R-HSA-8950269 Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor See in Reactome R-HSA-879942 ( R-HSA-512988 ) R-HSA-879942 Reaction Name: The receptor is activated See in Reactome R-HSA-8952823 ( R-HSA-9020933 ) R-HSA-8952823 Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor See in Reactome R-HSA-912757 ( R-HSA-512988 ) R-HSA-912757 Reaction Name: p-S585-IL3RB binds 14-3-3 proteins See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-2671839 ( R-HSA-2586552 ) R-HSA-2671839 Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9027273 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027273 Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-982810 ( R-HSA-1170546; R-HSA-982772 ) R-HSA-982810 Reaction Name: JAK2 phosphorylation See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8981093 ( R-HSA-9020591 ) R-HSA-8981093 Reaction Name: IL12 bound to IL12R internalises See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-1671691 ( R-HSA-1170546 ) R-HSA-1671691 Reaction Name: PRLR-bound STAT5 is phosphorylated See in Reactome R-HSA-447130 ( R-HSA-9020933 ) R-HSA-447130 Reaction Name: Interleukin-23 binds interleukin-23 receptor See in Reactome R-HSA-879937 ( R-HSA-512988 ) R-HSA-879937 Reaction Name: The common beta chain IL3RB binds JAK2 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-6785821 ( R-HSA-6785807 ) R-HSA-6785821 Reaction Name: SOCS5,(SOCS1) bind IL4RA See in Reactome R-HSA-9024726 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024726 Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-9029149 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029149 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-9006323 ( R-HSA-9006335 ) R-HSA-9006323 Reaction Name: Phospho-JAK2 phosphorylates EPOR See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-997237 ( R-HSA-983231 ) R-HSA-997237 Reaction Name: SH2B proteins bind JAK2 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-982778 ( R-HSA-982772 ) R-HSA-982778 Reaction Name: Growth hormone binds the growth hormone receptor See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-1170539 ( R-HSA-1170546 ) R-HSA-1170539 Reaction Name: Prolactin receptor is internalized See in Reactome R-HSA-9012650 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012650 Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-6786092 ( R-HSA-6785807 ) R-HSA-6786092 Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-879909 ( R-HSA-512988 ) R-HSA-879909 Reaction Name: Activation of STAT5a/b by JAK2 See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-450031 ( R-HSA-512988 ) R-HSA-450031 Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8950591 ( R-HSA-9020933 ) R-HSA-8950591 Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated See in Reactome R-HSA-9021627 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-913371 ( R-HSA-512988 ) R-HSA-913371 Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-1168894 ( R-HSA-982772 ) R-HSA-1168894 Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-2586559 ( R-HSA-2586552 ) R-HSA-2586559 Reaction Name: Leptin Binds Leptin Receptor See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-6786101 ( R-HSA-6785807 ) R-HSA-6786101 Reaction Name: IL4 binds IL4R:JAK2 See in Reactome R-HSA-1168839 ( R-HSA-982772 ) R-HSA-1168839 Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-8983878 ( R-HSA-8984722 ) R-HSA-8983878 Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-2671850 ( R-HSA-2586552 ) R-HSA-2671850 Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-1168767 ( R-HSA-982772 ) R-HSA-1168767 Reaction Name: JAK2 phosphorylates STAT1/STAT3 See in Reactome R-HSA-9029151 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029151 Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 See in Reactome R-HSA-447252 ( R-HSA-9020591 ) R-HSA-447252 Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2 See in Reactome R-HSA-1168394 ( R-HSA-982772 ) R-HSA-1168394 Reaction Name: STAT5 tyrosine phosphorylation See in Reactome R-HSA-1168393 ( R-HSA-982772 ) R-HSA-1168393 Reaction Name: STAT5 association with GHR See in Reactome R-HSA-9029155 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029155 Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-8952749 ( R-HSA-9020933 ) R-HSA-8952749 Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-1302698 ( R-HSA-1170546 ) R-HSA-1302698 Reaction Name: PRLR associates with JAK2 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-1675473 ( R-HSA-1170546 ) R-HSA-1675473 Reaction Name: SH2B binds JAK2 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1168445 ( R-HSA-982772 ) R-HSA-1168445 Reaction Name: PTP1B binds the GH receptor complex See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1364043 ( R-HSA-1170546 ) R-HSA-1364043 Reaction Name: Tyrosine phosphorylation of PRLR See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-9027373 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027373 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma See in Reactome R-HSA-8983872 ( R-HSA-8984722 ) R-HSA-8983872 Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-9029150 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029150 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-1168809 ( R-HSA-982772 ) R-HSA-1168809 Reaction Name: SOCS binding to GHR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-2671872 ( R-HSA-2586552 ) R-HSA-2671872 Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1 See in Reactome R-HSA-982807 ( R-HSA-982772 ) R-HSA-982807 Reaction Name: JAK2 phosphorylation of GHR See in Reactome R-HSA-9012657 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-982775 ( R-HSA-982772 ) R-HSA-982775 Reaction Name: Growth hormone receptor dimerizes See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-982768 ( R-HSA-982772 ) R-HSA-982768 Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change See in Reactome R-HSA-9027272 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027272 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-1168813 ( R-HSA-982772 ) R-HSA-1168813 Reaction Name: SOCS binding to JAK2 See in Reactome
MONDO:0009891	JAK1	P23458	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-1169408 R-HSA-1169408 Reactome Name: ISG15 antiviral mechanism See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020958 R-HSA-9020958 Reactome Name: Interleukin-21 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-1266695 R-HSA-1266695 Reactome Name: Interleukin-7 signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-8985947 R-HSA-8985947 Reactome Name: Interleukin-9 signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-8983432 R-HSA-8983432 Reactome Name: Interleukin-15 signaling See in Reactome R-HSA-6783783 R-HSA-6783783 Reactome Name: Interleukin-10 signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-449836 R-HSA-449836 Reactome Name: Other interleukin signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-1169410 R-HSA-1169410 Reactome Name: Antiviral mechanism by IFN-stimulated genes See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Signal Transduction	R-HSA-9677585 ( R-HSA-9674555 ) R-HSA-9677585 Reaction Name: CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 See in Reactome R-HSA-909720 ( R-HSA-909733 ) R-HSA-909720 Reaction Name: IFN alpha/beta binds to IFNAR2 See in Reactome R-HSA-8987266 ( R-HSA-8854691 ) R-HSA-8987266 Reaction Name: IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 See in Reactome R-HSA-448708 ( R-HSA-8854691 ) R-HSA-448708 Reaction Name: IL24 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-8983335 ( R-HSA-8983432 ) R-HSA-8983335 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome See in Reactome R-HSA-8985988 ( R-HSA-8985947 ) R-HSA-8985988 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-6784319 ( R-HSA-6783783 ) R-HSA-6784319 Reaction Name: JAK1,TYK2 phosphorylate JAK1,TYK2 See in Reactome R-HSA-8987105 ( R-HSA-8854691 ) R-HSA-8987105 Reaction Name: IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-451900 ( R-HSA-9020558 ) R-HSA-451900 Reaction Name: IL2RB binds JAK1 See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-8987015 ( R-HSA-8854691 ) R-HSA-8987015 Reaction Name: IL20 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-452091 ( R-HSA-9020558 ) R-HSA-452091 Reaction Name: Phosphorylation of IL2RB Y338 enables SHC recruitment See in Reactome R-HSA-8854645 ( R-HSA-8854691 ) R-HSA-8854645 Reaction Name: IL22:IL22RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-9006873 ( R-HSA-9020958 ) R-HSA-9006873 Reaction Name: IL21 receptor STAT binding See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-9025969 ( R-HSA-1266695 ) R-HSA-9025969 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 See in Reactome R-HSA-9005980 ( R-HSA-9020958 ) R-HSA-9005980 Reaction Name: IL21 binds IL21R:JAK1 See in Reactome R-HSA-912680 ( R-HSA-909733; R-HSA-912694 ) R-HSA-912680 Reaction Name: Inhibition of JAK kinase activity by SOCS1/3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-448661 ( R-HSA-449836; R-HSA-8854691 ) R-HSA-448661 Reaction Name: IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-449811 ( R-HSA-6783783 ) R-HSA-449811 Reaction Name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-8987270 ( R-HSA-8854691 ) R-HSA-8987270 Reaction Name: p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9674558 ( R-HSA-9674555 ) R-HSA-9674558 Reaction Name: p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 See in Reactome R-HSA-8982165 ( R-HSA-8854691 ) R-HSA-8982165 Reaction Name: IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 See in Reactome R-HSA-9678935 ( R-HSA-909733 ) R-HSA-9678935 Reaction Name: IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors See in Reactome R-HSA-8983374 ( R-HSA-8983432 ) R-HSA-8983374 Reaction Name: p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 See in Reactome R-HSA-8987080 ( R-HSA-8854691 ) R-HSA-8987080 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8987039 ( R-HSA-8854691 ) R-HSA-8987039 Reaction Name: JAK1 binds IL20RA See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-8986480 ( R-HSA-8854691 ) R-HSA-8986480 Reaction Name: IL26:IL20RA:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-8985929 ( R-HSA-8985947 ) R-HSA-8985929 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-452100 ( R-HSA-9020558 ) R-HSA-452100 Reaction Name: SHC1 bound to IL2 receptor is phosphorylated See in Reactome R-HSA-8983425 ( R-HSA-8983432 ) R-HSA-8983425 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 See in Reactome R-HSA-6784791 ( R-HSA-6783783 ) R-HSA-6784791 Reaction Name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8987040 ( R-HSA-8854691 ) R-HSA-8987040 Reaction Name: IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 See in Reactome R-HSA-909718 ( R-HSA-909733 ) R-HSA-909718 Reaction Name: Formation of p-STAT1 homodimer See in Reactome R-HSA-449803 ( R-HSA-6783783 ) R-HSA-449803 Reaction Name: IL10 dimer binds IL10RA:JAK1 See in Reactome R-HSA-8987161 ( R-HSA-8854691 ) R-HSA-8987161 Reaction Name: p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 See in Reactome R-HSA-8987129 ( R-HSA-8854691 ) R-HSA-8987129 Reaction Name: JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-6784006 ( R-HSA-6783783 ) R-HSA-6784006 Reaction Name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 See in Reactome R-HSA-452108 ( R-HSA-9020558 ) R-HSA-452108 Reaction Name: Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-909729 ( R-HSA-909733 ) R-HSA-909729 Reaction Name: Activation of JAK kinases See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-8983371 ( R-HSA-8983432 ) R-HSA-8983371 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome R-HSA-997314 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997314 Reaction Name: Dephosphorylation of JAK1 by SHP1 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-6784324 ( R-HSA-6783783 ) R-HSA-6784324 Reaction Name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA See in Reactome R-HSA-450063 ( R-HSA-9020558 ) R-HSA-450063 Reaction Name: Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit See in Reactome R-HSA-8982162 ( R-HSA-8854691 ) R-HSA-8982162 Reaction Name: p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB See in Reactome R-HSA-8963734 ( R-HSA-8985947 ) R-HSA-8963734 Reaction Name: IL9 binds IL9R:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-1169406 ( R-HSA-1169408 ) R-HSA-1169406 Reaction Name: ISGylation of host proteins See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-8987120 ( R-HSA-8854691 ) R-HSA-8987120 Reaction Name: JAK1 binds IFNLR1 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-452097 ( R-HSA-9020558 ) R-HSA-452097 Reaction Name: Recruited STAT5 is phosphorylated See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8983298 ( R-HSA-8983432 ) R-HSA-8983298 Reaction Name: IL15 binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-448480 ( R-HSA-8854691 ) R-HSA-448480 Reaction Name: IL22 binds IL22RA1:JAK1 receptor complex See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-909730 ( R-HSA-909733 ) R-HSA-909730 Reaction Name: Phosphorylation of INFAR1 by TYK2 See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-919404 ( R-HSA-9020558 ) R-HSA-919404 Reaction Name: Phosphorylated STAT5 is released See in Reactome R-HSA-8986972 ( R-HSA-8854691 ) R-HSA-8986972 Reaction Name: IL24 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8983424 ( R-HSA-8983432 ) R-HSA-8983424 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-9009700 ( R-HSA-8983432 ) R-HSA-9009700 Reaction Name: IL2RB and IL2RG are phosphorylated See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-8983394 ( R-HSA-8983432 ) R-HSA-8983394 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 See in Reactome R-HSA-9677579 ( R-HSA-9674555 ) R-HSA-9677579 Reaction Name: CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN See in Reactome R-HSA-8986994 ( R-HSA-8854691 ) R-HSA-8986994 Reaction Name: IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-449958 ( R-HSA-1266695 ) R-HSA-449958 Reaction Name: IL7:IL7R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-8950716 ( R-HSA-9020956 ) R-HSA-8950716 Reaction Name: IL27RA binds JAK1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-1264832 ( R-HSA-1266695 ) R-HSA-1264832 Reaction Name: JAK1 binds IL7R See in Reactome R-HSA-8987202 ( R-HSA-8854691 ) R-HSA-8987202 Reaction Name: IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-909724 ( R-HSA-909733 ) R-HSA-909724 Reaction Name: Recruitment of IFNAR1 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-8987097 ( R-HSA-8854691 ) R-HSA-8987097 Reaction Name: IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 See in Reactome R-HSA-997311 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997311 Reaction Name: Dephosphorylation of TYK2 by PTP1B See in Reactome R-HSA-8987042 ( R-HSA-8854691 ) R-HSA-8987042 Reaction Name: IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-448744 ( R-HSA-8854691 ) R-HSA-448744 Reaction Name: IL20RA binds IL20RB See in Reactome R-HSA-8986446 ( R-HSA-8854691 ) R-HSA-8986446 Reaction Name: IL26 binds IL20RA:JAK1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-8985900 ( R-HSA-8985947 ) R-HSA-8985900 Reaction Name: p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 See in Reactome R-HSA-1678841 ( R-HSA-1169408 ) R-HSA-1678841 Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-8987012 ( R-HSA-8854691 ) R-HSA-8987012 Reaction Name: IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-909719 ( R-HSA-909733 ) R-HSA-909719 Reaction Name: Recruitment of STAT2 to p-IFNAR1 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-9006844 ( R-HSA-9020958 ) R-HSA-9006844 Reaction Name: IL21:IL21R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-909732 ( R-HSA-909733 ) R-HSA-909732 Reaction Name: Phosphorylation of STAT2 See in Reactome R-HSA-9009227 ( R-HSA-8854691 ) R-HSA-9009227 Reaction Name: IL20 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-6785165 ( R-HSA-1266695 ) R-HSA-6785165 Reaction Name: p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-1295540 ( R-HSA-1266695 ) R-HSA-1295540 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-8983063 ( R-HSA-1266695 ) R-HSA-8983063 Reaction Name: JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated See in Reactome R-HSA-8982163 ( R-HSA-8854691 ) R-HSA-8982163 Reaction Name: IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-450027 ( R-HSA-9020558 ) R-HSA-450027 Reaction Name: Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-8987255 ( R-HSA-8854691 ) R-HSA-8987255 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 See in Reactome R-HSA-1295519 ( R-HSA-1266695 ) R-HSA-1295519 Reaction Name: IL7R is phosphorylated on Y499 See in Reactome R-HSA-448728 ( R-HSA-8854691 ) R-HSA-448728 Reaction Name: IL19 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8987084 ( R-HSA-8854691 ) R-HSA-8987084 Reaction Name: IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-8983003 ( R-HSA-1266695 ) R-HSA-8983003 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 See in Reactome R-HSA-449978 ( R-HSA-1266695 ) R-HSA-449978 Reaction Name: IL7 binds IL7R:JAK1 See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9011748 ( R-HSA-8985947 ) R-HSA-9011748 Reaction Name: IL9R binds JAK1 See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-6784323 ( R-HSA-6783783 ) R-HSA-6784323 Reaction Name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-449115 ( R-HSA-8983432 ) R-HSA-449115 Reaction Name: IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987063 ( R-HSA-8854691 ) R-HSA-8987063 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 See in Reactome R-HSA-8987043 ( R-HSA-8854691 ) R-HSA-8987043 Reaction Name: IL22RA1 binds JAK1 See in Reactome R-HSA-8983384 ( R-HSA-8983432 ) R-HSA-8983384 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-9006850 ( R-HSA-9020958 ) R-HSA-9006850 Reaction Name: IL21 receptor JAK phosphorylation See in Reactome R-HSA-8987150 ( R-HSA-8854691 ) R-HSA-8987150 Reaction Name: IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-8983300 ( R-HSA-8983432 ) R-HSA-8983300 Reaction Name: IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-8987096 ( R-HSA-8854691 ) R-HSA-8987096 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-8986995 ( R-HSA-8854691 ) R-HSA-8986995 Reaction Name: IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA See in Reactome R-HSA-8986985 ( R-HSA-8854691 ) R-HSA-8986985 Reaction Name: IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-452122 ( R-HSA-9020558 ) R-HSA-452122 Reaction Name: JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB See in Reactome R-HSA-909722 ( R-HSA-909733 ) R-HSA-909722 Reaction Name: Release of p-STAT2:p-STAT1 dimer See in Reactome R-HSA-8987033 ( R-HSA-8854691 ) R-HSA-8987033 Reaction Name: p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-8983309 ( R-HSA-8983432 ) R-HSA-8983309 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 See in Reactome R-HSA-448660 ( R-HSA-6788467 ) R-HSA-448660 Reaction Name: IL31:IL31RA:JAK1 binds OSMR:JAK1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-8985973 ( R-HSA-8985947 ) R-HSA-8985973 Reaction Name: IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 See in Reactome R-HSA-451942 ( R-HSA-9020558 ) R-HSA-451942 Reaction Name: Within the IL-2R complex JAK3 phosphorylates JAK1 See in Reactome R-HSA-9006870 ( R-HSA-9020958 ) R-HSA-9006870 Reaction Name: IL21 receptor STAT phosphorylation See in Reactome R-HSA-8985914 ( R-HSA-8985947 ) R-HSA-8985914 Reaction Name: IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-8983299 ( R-HSA-8983432 ) R-HSA-8983299 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-8983378 ( R-HSA-8983432 ) R-HSA-8983378 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-8987230 ( R-HSA-8854691 ) R-HSA-8987230 Reaction Name: p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1295516 ( R-HSA-1266695 ) R-HSA-1295516 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-9674546 ( R-HSA-9674555 ) R-HSA-9674546 Reaction Name: CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1 See in Reactome
MONDO:0010379	MAOA	P21397	1.4.3.4	R-HSA-379398 R-HSA-379398 Reactome Name: Enzymatic degradation of Dopamine by monoamine oxidase See in Reactome R-HSA-380612 R-HSA-380612 Reactome Name: Metabolism of serotonin See in Reactome R-HSA-379397 R-HSA-379397 Reactome Name: Enzymatic degradation of dopamine by COMT See in Reactome R-HSA-181430 R-HSA-181430 Reactome Name: Norepinephrine Neurotransmitter Release Cycle See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-141333 R-HSA-141333 Reactome Name: Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB See in Reactome	R-HSA-380615 R-HSA-380615 Reactome Name: Serotonin clearance from the synaptic cleft See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-379401 R-HSA-379401 Reactome Name: Dopamine clearance from the synaptic cleft See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-211945 R-HSA-211945 Reactome Name: Phase I - Functionalization of compounds See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-140179 R-HSA-140179 Reactome Name: Amine Oxidase reactions See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-112310 R-HSA-112310 Reactome Name: Neurotransmitter release cycle See in Reactome R-HSA-112311 R-HSA-112311 Reactome Name: Neurotransmitter clearance See in Reactome	Immune System Metabolism Neuronal System	R-HSA-141186 ( R-HSA-141333; R-HSA-380612 ) R-HSA-141186 Reaction Name: MAOA:FAD oxidatively deaminates of 5HT See in Reactome R-HSA-374909 ( R-HSA-181430 ) R-HSA-374909 Reaction Name: Metabolism of Noradrenaline See in Reactome R-HSA-379382 ( R-HSA-379398 ) R-HSA-379382 Reaction Name: MAOA:FAD deaminates DA to DOPAC See in Reactome R-HSA-379395 ( R-HSA-379397 ) R-HSA-379395 Reaction Name: MAOA:FAD deaminates 3MT to HVA See in Reactome R-HSA-6797271 ( R-HSA-6785807 ) R-HSA-6797271 Reaction Name: Expression of MAOA See in Reactome
MONDO:0010938	JAK3	P52333	2.7.10.2	R-HSA-8985947 R-HSA-8985947 Reactome Name: Interleukin-9 signaling See in Reactome R-HSA-1266695 R-HSA-1266695 Reactome Name: Interleukin-7 signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-8983432 R-HSA-8983432 Reactome Name: Interleukin-15 signaling See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020958 R-HSA-9020958 Reactome Name: Interleukin-21 signaling See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Signal Transduction	R-HSA-1295516 ( R-HSA-1266695 ) R-HSA-1295516 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits See in Reactome R-HSA-1295519 ( R-HSA-1266695 ) R-HSA-1295519 Reaction Name: IL7R is phosphorylated on Y499 See in Reactome R-HSA-1295540 ( R-HSA-1266695 ) R-HSA-1295540 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 See in Reactome R-HSA-449115 ( R-HSA-8983432 ) R-HSA-449115 Reaction Name: IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-449958 ( R-HSA-1266695 ) R-HSA-449958 Reaction Name: IL7:IL7R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-450063 ( R-HSA-9020558 ) R-HSA-450063 Reaction Name: Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit See in Reactome R-HSA-451895 ( R-HSA-1266695; R-HSA-6785807; R-HSA-8985947; R-HSA-9020558 ) R-HSA-451895 Reaction Name: IL2RG binds JAK3 See in Reactome R-HSA-451942 ( R-HSA-9020558 ) R-HSA-451942 Reaction Name: Within the IL-2R complex JAK3 phosphorylates JAK1 See in Reactome R-HSA-452091 ( R-HSA-9020558 ) R-HSA-452091 Reaction Name: Phosphorylation of IL2RB Y338 enables SHC recruitment See in Reactome R-HSA-452097 ( R-HSA-9020558 ) R-HSA-452097 Reaction Name: Recruited STAT5 is phosphorylated See in Reactome R-HSA-452100 ( R-HSA-9020558 ) R-HSA-452100 Reaction Name: SHC1 bound to IL2 receptor is phosphorylated See in Reactome R-HSA-452108 ( R-HSA-9020558 ) R-HSA-452108 Reaction Name: Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment See in Reactome R-HSA-452122 ( R-HSA-9020558 ) R-HSA-452122 Reaction Name: JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-508451 ( R-HSA-9020558 ) R-HSA-508451 Reaction Name: PTK2B is phosphorylated See in Reactome R-HSA-508513 ( R-HSA-9020558 ) R-HSA-508513 Reaction Name: PTK2B binds JAK3 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785165 ( R-HSA-1266695 ) R-HSA-6785165 Reaction Name: p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-6786092 ( R-HSA-6785807 ) R-HSA-6786092 Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3 See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-8963734 ( R-HSA-8985947 ) R-HSA-8963734 Reaction Name: IL9 binds IL9R:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8983003 ( R-HSA-1266695 ) R-HSA-8983003 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 See in Reactome R-HSA-8983063 ( R-HSA-1266695 ) R-HSA-8983063 Reaction Name: JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated See in Reactome R-HSA-8983298 ( R-HSA-8983432 ) R-HSA-8983298 Reaction Name: IL15 binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8983299 ( R-HSA-8983432 ) R-HSA-8983299 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 See in Reactome R-HSA-8983300 ( R-HSA-8983432 ) R-HSA-8983300 Reaction Name: IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 See in Reactome R-HSA-8983309 ( R-HSA-8983432 ) R-HSA-8983309 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 See in Reactome R-HSA-8983335 ( R-HSA-8983432 ) R-HSA-8983335 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome See in Reactome R-HSA-8983371 ( R-HSA-8983432 ) R-HSA-8983371 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 See in Reactome R-HSA-8983374 ( R-HSA-8983432 ) R-HSA-8983374 Reaction Name: p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 See in Reactome R-HSA-8983378 ( R-HSA-8983432 ) R-HSA-8983378 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 See in Reactome R-HSA-8983384 ( R-HSA-8983432 ) R-HSA-8983384 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 See in Reactome R-HSA-8983394 ( R-HSA-8983432 ) R-HSA-8983394 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 See in Reactome R-HSA-8983424 ( R-HSA-8983432 ) R-HSA-8983424 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 See in Reactome R-HSA-8983425 ( R-HSA-8983432 ) R-HSA-8983425 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 See in Reactome R-HSA-8985900 ( R-HSA-8985947 ) R-HSA-8985900 Reaction Name: p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 See in Reactome R-HSA-8985914 ( R-HSA-8985947 ) R-HSA-8985914 Reaction Name: IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 See in Reactome R-HSA-8985929 ( R-HSA-8985947 ) R-HSA-8985929 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B See in Reactome R-HSA-8985973 ( R-HSA-8985947 ) R-HSA-8985973 Reaction Name: IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 See in Reactome R-HSA-8985988 ( R-HSA-8985947 ) R-HSA-8985988 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-9006844 ( R-HSA-9020958 ) R-HSA-9006844 Reaction Name: IL21:IL21R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-9006850 ( R-HSA-9020958 ) R-HSA-9006850 Reaction Name: IL21 receptor JAK phosphorylation See in Reactome R-HSA-9006870 ( R-HSA-9020958 ) R-HSA-9006870 Reaction Name: IL21 receptor STAT phosphorylation See in Reactome R-HSA-9006873 ( R-HSA-9020958 ) R-HSA-9006873 Reaction Name: IL21 receptor STAT binding See in Reactome R-HSA-9009700 ( R-HSA-8983432 ) R-HSA-9009700 Reaction Name: IL2RB and IL2RG are phosphorylated See in Reactome R-HSA-9025969 ( R-HSA-1266695 ) R-HSA-9025969 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-919404 ( R-HSA-9020558 ) R-HSA-919404 Reaction Name: Phosphorylated STAT5 is released See in Reactome R-HSA-9679028 ( R-HSA-1266695; R-HSA-6785807; R-HSA-8985947; R-HSA-9020558 ) R-HSA-9679028 Reaction Name: JAK3 binds JAK3 inhibitors See in Reactome R-HSA-9701485 ( R-HSA-201556 ) R-HSA-9701485 Reaction Name: Active ALK binds JAK3 See in Reactome R-HSA-9701488 ( R-HSA-201556 ) R-HSA-9701488 Reaction Name: Active ALK phosphorylates JAK3 See in Reactome R-HSA-9701507 ( R-HSA-201556 ) R-HSA-9701507 Reaction Name: PTPN6 dephosphorylates JAK3 See in Reactome
MONDO:0010947	JAK2	O60674	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-9027277 R-HSA-9027277 Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG) See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-9027283 R-HSA-9027283 Reactome Name: Erythropoietin activates STAT5 See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-3214858 R-HSA-3214858 Reactome Name: RMTs methylate histone arginines See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Chromatin organization Cell Cycle Hemostasis Signal Transduction	R-HSA-1168456 ( R-HSA-982772 ) R-HSA-1168456 Reaction Name: Growth hormone receptor binds Lyn See in Reactome R-HSA-8983870 ( R-HSA-8984722 ) R-HSA-8983870 Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated See in Reactome R-HSA-2671862 ( R-HSA-2586552 ) R-HSA-2671862 Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin See in Reactome R-HSA-6786070 ( R-HSA-6785807 ) R-HSA-6786070 Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950737 ( R-HSA-9020933 ) R-HSA-8950737 Reaction Name: IL23R binds JAK2 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8950423 ( R-HSA-9020591 ) R-HSA-8950423 Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-2586555 ( R-HSA-2586552 ) R-HSA-2586555 Reaction Name: JAK2 Autophosphorylates in Response to Leptin See in Reactome R-HSA-1370500 ( R-HSA-1170546 ) R-HSA-1370500 Reaction Name: PRLR binds SCF beta-TrCP complex See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-1169192 ( R-HSA-982772 ) R-HSA-1169192 Reaction Name: PTP1B dephosphorylates GHR See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-9012651 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012651 Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-6785898 ( R-HSA-6785807 ) R-HSA-6785898 Reaction Name: IL4R binds JAK2 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-2672302 ( R-HSA-2586552 ) R-HSA-2672302 Reaction Name: Phosphorylated LEPR Binds SOCS3 See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-8950063 ( R-HSA-9020591 ) R-HSA-8950063 Reaction Name: IL12RB2 binds JAK2 See in Reactome R-HSA-921155 ( R-HSA-512988 ) R-HSA-921155 Reaction Name: p-STAT5 dissociates from the receptor complex See in Reactome R-HSA-9027274 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9027274 Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-2586553 ( R-HSA-2586552 ) R-HSA-2586553 Reaction Name: JAK2 Phosphorylates LEPR See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-9006332 ( R-HSA-9006335 ) R-HSA-9006332 Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin See in Reactome R-HSA-879925 ( R-HSA-512988 ) R-HSA-879925 Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated See in Reactome R-HSA-2671855 ( R-HSA-2586552 ) R-HSA-2671855 Reaction Name: Phosphorylated LEPR Binds STAT5 See in Reactome R-HSA-1169210 ( R-HSA-982772 ) R-HSA-1169210 Reaction Name: PTP1B dephosphorylates JAK2 See in Reactome R-HSA-9027281 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027281 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-447226 ( R-HSA-9020591 ) R-HSA-447226 Reaction Name: Interleukin-12 binds Interleukin-12 receptor See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-9012654 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012654 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950583 ( R-HSA-9020933 ) R-HSA-8950583 Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9027280 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-1370505 ( R-HSA-1170546 ) R-HSA-1370505 Reaction Name: PRLR is phosphorylated at Ser-349 See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-8983876 ( R-HSA-8984722 ) R-HSA-8983876 Reaction Name: STAT4 binds IL12RB2:IL12RB2 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8950364 ( R-HSA-9020933 ) R-HSA-8950364 Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-8950128 ( R-HSA-9020591 ) R-HSA-8950128 Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor See in Reactome R-HSA-879907 ( R-HSA-512988 ) R-HSA-879907 Reaction Name: Tyrosine kinases phosphorylate the receptor See in Reactome R-HSA-1168423 ( R-HSA-982772 ) R-HSA-1168423 Reaction Name: JAK2 phosphorylation of IRS-1/2 See in Reactome R-HSA-1168768 ( R-HSA-982772 ) R-HSA-1168768 Reaction Name: JAK2 binds STAT1/3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-2671829 ( R-HSA-2586552 ) R-HSA-2671829 Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-976991 ( R-HSA-1170546 ) R-HSA-976991 Reaction Name: Prolactin receptor ligands bind the prolactin receptor See in Reactome R-HSA-1671687 ( R-HSA-1170546 ) R-HSA-1671687 Reaction Name: PRLR activation See in Reactome R-HSA-9032478 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9032478 Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-9006325 ( R-HSA-9006335 ) R-HSA-9006325 Reaction Name: EPO binds EPOR:JAK2:LYN:IRS2 See in Reactome R-HSA-9029158 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-982792 ( R-HSA-982772 ) R-HSA-982792 Reaction Name: Growth hormone receptor binds JAK2 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-9027425 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027425 Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 See in Reactome R-HSA-9024723 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024723 Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1 See in Reactome R-HSA-879930 ( R-HSA-512988 ) R-HSA-879930 Reaction Name: STAT5 is recruited by JAK2 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-1169188 ( R-HSA-982772 ) R-HSA-1169188 Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-879910 ( R-HSA-512988 ) R-HSA-879910 Reaction Name: JAK2 is phosphorylated, activated See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-2671876 ( R-HSA-2586552 ) R-HSA-2671876 Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor See in Reactome R-HSA-2671868 ( R-HSA-2586552 ) R-HSA-2671868 Reaction Name: Phosphorylated LEPR Binds STAT3 See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-879934 ( R-HSA-512988 ) R-HSA-879934 Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain See in Reactome R-HSA-6786114 ( R-HSA-6785807 ) R-HSA-6786114 Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2 See in Reactome R-HSA-913451 ( R-HSA-512988 ) R-HSA-913451 Reaction Name: IL3RB is phosphorylated on Ser-585 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-8983519 ( R-HSA-8984722 ) R-HSA-8983519 Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-913370 ( R-HSA-512988 ) R-HSA-913370 Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-2671873 ( R-HSA-2586552 ) R-HSA-2671873 Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-3215391 ( R-HSA-3214858 ) R-HSA-3215391 Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-1369080 ( R-HSA-1170546 ) R-HSA-1369080 Reaction Name: PRLR binds STAT5 See in Reactome R-HSA-1364044 ( R-HSA-1170546 ) R-HSA-1364044 Reaction Name: PRLR:JAK2 dimerizes See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-9027275 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8950269 ( R-HSA-9020933 ) R-HSA-8950269 Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor See in Reactome R-HSA-879942 ( R-HSA-512988 ) R-HSA-879942 Reaction Name: The receptor is activated See in Reactome R-HSA-8952823 ( R-HSA-9020933 ) R-HSA-8952823 Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor See in Reactome R-HSA-912757 ( R-HSA-512988 ) R-HSA-912757 Reaction Name: p-S585-IL3RB binds 14-3-3 proteins See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-2671839 ( R-HSA-2586552 ) R-HSA-2671839 Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9027273 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027273 Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-982810 ( R-HSA-1170546; R-HSA-982772 ) R-HSA-982810 Reaction Name: JAK2 phosphorylation See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8981093 ( R-HSA-9020591 ) R-HSA-8981093 Reaction Name: IL12 bound to IL12R internalises See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-1671691 ( R-HSA-1170546 ) R-HSA-1671691 Reaction Name: PRLR-bound STAT5 is phosphorylated See in Reactome R-HSA-447130 ( R-HSA-9020933 ) R-HSA-447130 Reaction Name: Interleukin-23 binds interleukin-23 receptor See in Reactome R-HSA-879937 ( R-HSA-512988 ) R-HSA-879937 Reaction Name: The common beta chain IL3RB binds JAK2 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-6785821 ( R-HSA-6785807 ) R-HSA-6785821 Reaction Name: SOCS5,(SOCS1) bind IL4RA See in Reactome R-HSA-9024726 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024726 Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-9029149 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029149 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-9006323 ( R-HSA-9006335 ) R-HSA-9006323 Reaction Name: Phospho-JAK2 phosphorylates EPOR See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-997237 ( R-HSA-983231 ) R-HSA-997237 Reaction Name: SH2B proteins bind JAK2 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-982778 ( R-HSA-982772 ) R-HSA-982778 Reaction Name: Growth hormone binds the growth hormone receptor See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-1170539 ( R-HSA-1170546 ) R-HSA-1170539 Reaction Name: Prolactin receptor is internalized See in Reactome R-HSA-9012650 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012650 Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-6786092 ( R-HSA-6785807 ) R-HSA-6786092 Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-879909 ( R-HSA-512988 ) R-HSA-879909 Reaction Name: Activation of STAT5a/b by JAK2 See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-450031 ( R-HSA-512988 ) R-HSA-450031 Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8950591 ( R-HSA-9020933 ) R-HSA-8950591 Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated See in Reactome R-HSA-9021627 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-913371 ( R-HSA-512988 ) R-HSA-913371 Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-1168894 ( R-HSA-982772 ) R-HSA-1168894 Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-2586559 ( R-HSA-2586552 ) R-HSA-2586559 Reaction Name: Leptin Binds Leptin Receptor See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-6786101 ( R-HSA-6785807 ) R-HSA-6786101 Reaction Name: IL4 binds IL4R:JAK2 See in Reactome R-HSA-1168839 ( R-HSA-982772 ) R-HSA-1168839 Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-8983878 ( R-HSA-8984722 ) R-HSA-8983878 Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-2671850 ( R-HSA-2586552 ) R-HSA-2671850 Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-1168767 ( R-HSA-982772 ) R-HSA-1168767 Reaction Name: JAK2 phosphorylates STAT1/STAT3 See in Reactome R-HSA-9029151 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029151 Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 See in Reactome R-HSA-447252 ( R-HSA-9020591 ) R-HSA-447252 Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2 See in Reactome R-HSA-1168394 ( R-HSA-982772 ) R-HSA-1168394 Reaction Name: STAT5 tyrosine phosphorylation See in Reactome R-HSA-1168393 ( R-HSA-982772 ) R-HSA-1168393 Reaction Name: STAT5 association with GHR See in Reactome R-HSA-9029155 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029155 Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-8952749 ( R-HSA-9020933 ) R-HSA-8952749 Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-1302698 ( R-HSA-1170546 ) R-HSA-1302698 Reaction Name: PRLR associates with JAK2 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-1675473 ( R-HSA-1170546 ) R-HSA-1675473 Reaction Name: SH2B binds JAK2 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1168445 ( R-HSA-982772 ) R-HSA-1168445 Reaction Name: PTP1B binds the GH receptor complex See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1364043 ( R-HSA-1170546 ) R-HSA-1364043 Reaction Name: Tyrosine phosphorylation of PRLR See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-9027373 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027373 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma See in Reactome R-HSA-8983872 ( R-HSA-8984722 ) R-HSA-8983872 Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-9029150 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029150 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-1168809 ( R-HSA-982772 ) R-HSA-1168809 Reaction Name: SOCS binding to GHR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-2671872 ( R-HSA-2586552 ) R-HSA-2671872 Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1 See in Reactome R-HSA-982807 ( R-HSA-982772 ) R-HSA-982807 Reaction Name: JAK2 phosphorylation of GHR See in Reactome R-HSA-9012657 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-982775 ( R-HSA-982772 ) R-HSA-982775 Reaction Name: Growth hormone receptor dimerizes See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-982768 ( R-HSA-982772 ) R-HSA-982768 Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change See in Reactome R-HSA-9027272 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027272 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-1168813 ( R-HSA-982772 ) R-HSA-1168813 Reaction Name: SOCS binding to JAK2 See in Reactome
MONDO:0011751	MMP1	P03956	3.4.24.7	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-210991 R-HSA-210991 Reactome Name: Basigin interactions See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Immune System Metabolism of proteins Extracellular matrix organization Hemostasis	R-HSA-1454757 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454757 Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 See in Reactome R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1454822 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454822 Reaction Name: Collagen type I degradation by MMP1,2,8,13, PRSS2 See in Reactome R-HSA-1474197 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474197 Reaction Name: Collagen type II degradation by MMP1,3,8,13,PRSS2 See in Reactome R-HSA-1474213 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474213 Reaction Name: Collagen type III degradation by MMP1,8,9,13 See in Reactome R-HSA-1564120 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564120 Reaction Name: Collagen type VII degradation by MMP1,2,3 See in Reactome R-HSA-1564143 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564143 Reaction Name: Collagen type X degradation by MMP1,2 See in Reactome R-HSA-1564169 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564169 Reaction Name: Collagen type VIII degradation by MMP1 See in Reactome R-HSA-1564179 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564179 Reaction Name: Collagen type XI degradation by MMP1,2,3,9 See in Reactome R-HSA-1566981 ( R-HSA-1474228 ) R-HSA-1566981 Reaction Name: Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS See in Reactome R-HSA-1592270 ( R-HSA-1474228 ) R-HSA-1592270 Reaction Name: NID1 degradation by MMP1, 9, 12, ELANE See in Reactome R-HSA-1592297 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592297 Reaction Name: Full activation of MMP1 See in Reactome R-HSA-1592316 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592316 Reaction Name: Initial activation of proMMP1 See in Reactome R-HSA-1592436 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592436 Reaction Name: Initial activation of proMMP9 by MMPs See in Reactome R-HSA-1602473 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602473 Reaction Name: Autocatalytic activation of MMP1 See in Reactome R-HSA-1604359 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604359 Reaction Name: Initial activation of proMMP2 by MMP1, 7 See in Reactome R-HSA-1604690 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604690 Reaction Name: Activation of MMP9 intermediate form by MMPs See in Reactome R-HSA-375135 ( R-HSA-1474228; R-HSA-210991 ) R-HSA-375135 Reaction Name: Basigin binds Matrix metalloproteinase-1 See in Reactome R-HSA-3791149 ( R-HSA-1474228 ) R-HSA-3791149 Reaction Name: Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 See in Reactome R-HSA-3791295 ( R-HSA-1474228 ) R-HSA-3791295 Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13 See in Reactome R-HSA-381435 ( R-HSA-381426 ) R-HSA-381435 Reaction Name: Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS See in Reactome R-HSA-6789615 ( R-HSA-6785807 ) R-HSA-6789615 Reaction Name: Expression of STAT3-upregulated extracellular proteins See in Reactome
MONDO:0012031	CD36	P16671	-	R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-434313 R-HSA-434313 Reactome Name: Intracellular metabolism of fatty acids regulates insulin secretion See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome R-HSA-1236973 R-HSA-1236973 Reactome Name: Cross-presentation of particulate exogenous antigens (phagosomes) See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-1236974 R-HSA-1236974 Reactome Name: ER-Phagosome pathway See in Reactome R-HSA-3000471 R-HSA-3000471 Reactome Name: Scavenging by Class B Receptors See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5686938 R-HSA-5686938 Reactome Name: Regulation of TLR by endogenous ligand See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-400451 R-HSA-400451 Reactome Name: Free fatty acids regulate insulin secretion See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-2173782 R-HSA-2173782 Reactome Name: Binding and Uptake of Ligands by Scavenger Receptors See in Reactome	Immune System Metabolism Developmental Biology Vesicle-mediated transport Hemostasis	R-HSA-1236956 ( R-HSA-1236973 ) R-HSA-1236956 Reaction Name: Engulfment of particulate antigen into phagocytic vesicle See in Reactome R-HSA-1236958 ( R-HSA-1236973 ) R-HSA-1236958 Reaction Name: Interaction of particulate antigens with dendritic cell receptors See in Reactome R-HSA-166072 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166072 Reaction Name: MyD88 forms a complex with TIRAP:activated TLR2/4 See in Reactome R-HSA-166082 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166082 Reaction Name: IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex See in Reactome R-HSA-166091 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166091 Reaction Name: IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex See in Reactome R-HSA-166119 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166119 Reaction Name: First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal See in Reactome R-HSA-166284 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166284 Reaction Name: Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP See in Reactome R-HSA-166286 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166286 Reaction Name: Multiple IRAK1 autophosphorylation steps See in Reactome R-HSA-166362 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166362 Reaction Name: Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-166363 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166363 Reaction Name: TRAF6 binds to hp- IRAK1 See in Reactome R-HSA-168950 ( R-HSA-168188 ) R-HSA-168950 Reaction Name: TLR6:TLR2 is recruited to ligand:CD14:CD36 See in Reactome R-HSA-2187264 ( R-HSA-3000471 ) R-HSA-2187264 Reaction Name: Platelet glycoprotein IV (CD36) binds ligands See in Reactome R-HSA-2201316 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2201316 Reaction Name: Activated TLR2/4 interacts with MAL (TIRAP) See in Reactome R-HSA-2201322 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2201322 Reaction Name: TIRAP is phosphorylated by BTK See in Reactome R-HSA-2247512 ( R-HSA-3000471 ) R-HSA-2247512 Reaction Name: Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed See in Reactome R-HSA-2262775 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2262775 Reaction Name: Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-2262777 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2262777 Reaction Name: TRAF6 binds to p-IRAK2 See in Reactome R-HSA-2559414 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2559414 Reaction Name: Activated TLR2/4:TIRAP interacts with BTK See in Reactome R-HSA-2559464 ( R-HSA-168188 ) R-HSA-2559464 Reaction Name: TLR6/2 ligand associates with CD14 and CD36 within lipid rafts See in Reactome R-HSA-434381 ( R-HSA-434313 ) R-HSA-434381 Reaction Name: CD36 (FAT) translocates palmitate from the extracellular region to the cytosol See in Reactome R-HSA-481044 ( R-HSA-114608 ) R-HSA-481044 Reaction Name: Surface deployment of platelet alpha granule membrane components See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-6797267 ( R-HSA-6785807 ) R-HSA-6797267 Reaction Name: Expression of CD36 See in Reactome R-HSA-6799350 ( R-HSA-6798695 ) R-HSA-6799350 Reaction Name: Exocytosis of specific granule membrane proteins See in Reactome R-HSA-8863895 ( R-HSA-1236974 ) R-HSA-8863895 Reaction Name: IKKB phosphorylates SNAP23 See in Reactome R-HSA-8869667 ( R-HSA-5686938 ) R-HSA-8869667 Reaction Name: oxLDL:CD36 binds TLR4:TLR6 See in Reactome R-HSA-937022 ( R-HSA-166058; R-HSA-168188 ) R-HSA-937022 Reaction Name: IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP See in Reactome R-HSA-937059 ( R-HSA-166058; R-HSA-168188 ) R-HSA-937059 Reaction Name: Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex See in Reactome R-HSA-937079 ( R-HSA-166058; R-HSA-168188 ) R-HSA-937079 Reaction Name: MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 See in Reactome
MONDO:0012585	CD36	P16671	-	R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-434313 R-HSA-434313 Reactome Name: Intracellular metabolism of fatty acids regulates insulin secretion See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome R-HSA-1236973 R-HSA-1236973 Reactome Name: Cross-presentation of particulate exogenous antigens (phagosomes) See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-1236974 R-HSA-1236974 Reactome Name: ER-Phagosome pathway See in Reactome R-HSA-3000471 R-HSA-3000471 Reactome Name: Scavenging by Class B Receptors See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5686938 R-HSA-5686938 Reactome Name: Regulation of TLR by endogenous ligand See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-400451 R-HSA-400451 Reactome Name: Free fatty acids regulate insulin secretion See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-2173782 R-HSA-2173782 Reactome Name: Binding and Uptake of Ligands by Scavenger Receptors See in Reactome	Immune System Metabolism Developmental Biology Vesicle-mediated transport Hemostasis	R-HSA-1236956 ( R-HSA-1236973 ) R-HSA-1236956 Reaction Name: Engulfment of particulate antigen into phagocytic vesicle See in Reactome R-HSA-1236958 ( R-HSA-1236973 ) R-HSA-1236958 Reaction Name: Interaction of particulate antigens with dendritic cell receptors See in Reactome R-HSA-166072 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166072 Reaction Name: MyD88 forms a complex with TIRAP:activated TLR2/4 See in Reactome R-HSA-166082 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166082 Reaction Name: IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex See in Reactome R-HSA-166091 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166091 Reaction Name: IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex See in Reactome R-HSA-166119 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166119 Reaction Name: First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal See in Reactome R-HSA-166284 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166284 Reaction Name: Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP See in Reactome R-HSA-166286 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166286 Reaction Name: Multiple IRAK1 autophosphorylation steps See in Reactome R-HSA-166362 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166362 Reaction Name: Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-166363 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166363 Reaction Name: TRAF6 binds to hp- IRAK1 See in Reactome R-HSA-168950 ( R-HSA-168188 ) R-HSA-168950 Reaction Name: TLR6:TLR2 is recruited to ligand:CD14:CD36 See in Reactome R-HSA-2187264 ( R-HSA-3000471 ) R-HSA-2187264 Reaction Name: Platelet glycoprotein IV (CD36) binds ligands See in Reactome R-HSA-2201316 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2201316 Reaction Name: Activated TLR2/4 interacts with MAL (TIRAP) See in Reactome R-HSA-2201322 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2201322 Reaction Name: TIRAP is phosphorylated by BTK See in Reactome R-HSA-2247512 ( R-HSA-3000471 ) R-HSA-2247512 Reaction Name: Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed See in Reactome R-HSA-2262775 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2262775 Reaction Name: Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-2262777 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2262777 Reaction Name: TRAF6 binds to p-IRAK2 See in Reactome R-HSA-2559414 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2559414 Reaction Name: Activated TLR2/4:TIRAP interacts with BTK See in Reactome R-HSA-2559464 ( R-HSA-168188 ) R-HSA-2559464 Reaction Name: TLR6/2 ligand associates with CD14 and CD36 within lipid rafts See in Reactome R-HSA-434381 ( R-HSA-434313 ) R-HSA-434381 Reaction Name: CD36 (FAT) translocates palmitate from the extracellular region to the cytosol See in Reactome R-HSA-481044 ( R-HSA-114608 ) R-HSA-481044 Reaction Name: Surface deployment of platelet alpha granule membrane components See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-6797267 ( R-HSA-6785807 ) R-HSA-6797267 Reaction Name: Expression of CD36 See in Reactome R-HSA-6799350 ( R-HSA-6798695 ) R-HSA-6799350 Reaction Name: Exocytosis of specific granule membrane proteins See in Reactome R-HSA-8863895 ( R-HSA-1236974 ) R-HSA-8863895 Reaction Name: IKKB phosphorylates SNAP23 See in Reactome R-HSA-8869667 ( R-HSA-5686938 ) R-HSA-8869667 Reaction Name: oxLDL:CD36 binds TLR4:TLR6 See in Reactome R-HSA-937022 ( R-HSA-166058; R-HSA-168188 ) R-HSA-937022 Reaction Name: IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP See in Reactome R-HSA-937059 ( R-HSA-166058; R-HSA-168188 ) R-HSA-937059 Reaction Name: Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex See in Reactome R-HSA-937079 ( R-HSA-166058; R-HSA-168188 ) R-HSA-937079 Reaction Name: MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 See in Reactome
MONDO:0012682	TYK2	P29597	2.7.10.2	R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-449836 R-HSA-449836 Reactome Name: Other interleukin signaling See in Reactome R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-6783783 R-HSA-6783783 Reactome Name: Interleukin-10 signaling See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Signal Transduction	R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-447130 ( R-HSA-9020933 ) R-HSA-447130 Reaction Name: Interleukin-23 binds interleukin-23 receptor See in Reactome R-HSA-447226 ( R-HSA-9020591 ) R-HSA-447226 Reaction Name: Interleukin-12 binds Interleukin-12 receptor See in Reactome R-HSA-447252 ( R-HSA-9020591 ) R-HSA-447252 Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-448661 ( R-HSA-449836; R-HSA-8854691 ) R-HSA-448661 Reaction Name: IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-449811 ( R-HSA-6783783 ) R-HSA-449811 Reaction Name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-6784006 ( R-HSA-6783783 ) R-HSA-6784006 Reaction Name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-6784319 ( R-HSA-6783783 ) R-HSA-6784319 Reaction Name: JAK1,TYK2 phosphorylate JAK1,TYK2 See in Reactome R-HSA-6784323 ( R-HSA-6783783 ) R-HSA-6784323 Reaction Name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 See in Reactome R-HSA-6784324 ( R-HSA-6783783 ) R-HSA-6784324 Reaction Name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA See in Reactome R-HSA-6784791 ( R-HSA-6783783 ) R-HSA-6784791 Reaction Name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 See in Reactome R-HSA-6785762 ( R-HSA-6785807 ) R-HSA-6785762 Reaction Name: IL13RA1 binds TYK2 See in Reactome R-HSA-6785821 ( R-HSA-6785807 ) R-HSA-6785821 Reaction Name: SOCS5,(SOCS1) bind IL4RA See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-6786070 ( R-HSA-6785807 ) R-HSA-6786070 Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2 See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-6786114 ( R-HSA-6785807 ) R-HSA-6786114 Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2 See in Reactome R-HSA-6786118 ( R-HSA-6785807 ) R-HSA-6786118 Reaction Name: IL13 binds IL13RA:TYK2 See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-8854645 ( R-HSA-8854691 ) R-HSA-8854645 Reaction Name: IL22:IL22RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-8950057 ( R-HSA-9020591 ) R-HSA-8950057 Reaction Name: IL12RB1 binds TYK2 See in Reactome R-HSA-8950128 ( R-HSA-9020591 ) R-HSA-8950128 Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-8950269 ( R-HSA-9020933 ) R-HSA-8950269 Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950364 ( R-HSA-9020933 ) R-HSA-8950364 Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8950423 ( R-HSA-9020591 ) R-HSA-8950423 Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-8950583 ( R-HSA-9020933 ) R-HSA-8950583 Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-8950591 ( R-HSA-9020933 ) R-HSA-8950591 Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-8952749 ( R-HSA-9020933 ) R-HSA-8952749 Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-8952823 ( R-HSA-9020933 ) R-HSA-8952823 Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor See in Reactome R-HSA-8981093 ( R-HSA-9020591 ) R-HSA-8981093 Reaction Name: IL12 bound to IL12R internalises See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-8986480 ( R-HSA-8854691 ) R-HSA-8986480 Reaction Name: IL26:IL20RA:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-8986985 ( R-HSA-8854691 ) R-HSA-8986985 Reaction Name: IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 See in Reactome R-HSA-8986994 ( R-HSA-8854691 ) R-HSA-8986994 Reaction Name: IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 See in Reactome R-HSA-8986995 ( R-HSA-8854691 ) R-HSA-8986995 Reaction Name: IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-8987033 ( R-HSA-8854691 ) R-HSA-8987033 Reaction Name: p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 See in Reactome R-HSA-8987040 ( R-HSA-8854691 ) R-HSA-8987040 Reaction Name: IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 See in Reactome R-HSA-8987042 ( R-HSA-8854691 ) R-HSA-8987042 Reaction Name: IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8987080 ( R-HSA-8854691 ) R-HSA-8987080 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 See in Reactome R-HSA-8987105 ( R-HSA-8854691 ) R-HSA-8987105 Reaction Name: IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-8987202 ( R-HSA-8854691 ) R-HSA-8987202 Reaction Name: IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-8987223 ( R-HSA-8854691 ) R-HSA-8987223 Reaction Name: IL10RB binds TYK2 See in Reactome R-HSA-8987230 ( R-HSA-8854691 ) R-HSA-8987230 Reaction Name: p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-8987255 ( R-HSA-8854691 ) R-HSA-8987255 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 See in Reactome R-HSA-8987266 ( R-HSA-8854691 ) R-HSA-8987266 Reaction Name: IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 See in Reactome R-HSA-909718 ( R-HSA-909733 ) R-HSA-909718 Reaction Name: Formation of p-STAT1 homodimer See in Reactome R-HSA-909719 ( R-HSA-909733 ) R-HSA-909719 Reaction Name: Recruitment of STAT2 to p-IFNAR1 See in Reactome R-HSA-909722 ( R-HSA-909733 ) R-HSA-909722 Reaction Name: Release of p-STAT2:p-STAT1 dimer See in Reactome R-HSA-909724 ( R-HSA-909733 ) R-HSA-909724 Reaction Name: Recruitment of IFNAR1 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-909729 ( R-HSA-909733 ) R-HSA-909729 Reaction Name: Activation of JAK kinases See in Reactome R-HSA-909730 ( R-HSA-909733 ) R-HSA-909730 Reaction Name: Phosphorylation of INFAR1 by TYK2 See in Reactome R-HSA-909732 ( R-HSA-909733 ) R-HSA-909732 Reaction Name: Phosphorylation of STAT2 See in Reactome R-HSA-912680 ( R-HSA-909733; R-HSA-912694 ) R-HSA-912680 Reaction Name: Inhibition of JAK kinase activity by SOCS1/3 See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-9678737 ( R-HSA-909733 ) R-HSA-9678737 Reaction Name: IFNAR1:TYK2 binds TYK2 inhibitors See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome R-HSA-997311 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997311 Reaction Name: Dephosphorylation of TYK2 by PTP1B See in Reactome R-HSA-997314 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997314 Reaction Name: Dephosphorylation of JAK1 by SHP1 See in Reactome
MONDO:0013113	MMP9	P14780	3.4.24.35	R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1433374 ( R-HSA-1433557 ) R-HSA-1433374 Reaction Name: Processing of SCF isoform 1 See in Reactome R-HSA-1454757 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454757 Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 See in Reactome R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1454791 ( R-HSA-1474228 ) R-HSA-1454791 Reaction Name: MMP2, MMP7, MMP9 bind CD44 See in Reactome R-HSA-1474213 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474213 Reaction Name: Collagen type III degradation by MMP1,8,9,13 See in Reactome R-HSA-1564112 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564112 Reaction Name: Collagen type VI degradation by MMP2,9,11 See in Reactome R-HSA-1564117 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564117 Reaction Name: Collagen type XIV degradation by MMP9,13 See in Reactome R-HSA-1564142 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564142 Reaction Name: Collagen type IV degradation by MMP2,3,4,9,10,12 See in Reactome R-HSA-1564164 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564164 Reaction Name: Collagen type V degradation by MMP2,9,10 See in Reactome R-HSA-1564179 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564179 Reaction Name: Collagen type XI degradation by MMP1,2,3,9 See in Reactome R-HSA-1566962 ( R-HSA-1474228 ) R-HSA-1566962 Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases See in Reactome R-HSA-1592270 ( R-HSA-1474228 ) R-HSA-1592270 Reaction Name: NID1 degradation by MMP1, 9, 12, ELANE See in Reactome R-HSA-1592436 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592436 Reaction Name: Initial activation of proMMP9 by MMPs See in Reactome R-HSA-1602454 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602454 Reaction Name: proMMP9 binds TIMP1 See in Reactome R-HSA-1604690 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604690 Reaction Name: Activation of MMP9 intermediate form by MMPs See in Reactome R-HSA-1604722 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604722 Reaction Name: Activation of proMMP9 by proteases See in Reactome R-HSA-2168923 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168923 Reaction Name: Collagen type XVIII endostatin release See in Reactome R-HSA-2168982 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168982 Reaction Name: Collagen type XVI degradation by MMP9 See in Reactome R-HSA-2213200 ( R-HSA-2022090 ) R-HSA-2213200 Reaction Name: Release of endostatin-like peptides See in Reactome R-HSA-2485148 ( R-HSA-1474228 ) R-HSA-2485148 Reaction Name: Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 See in Reactome R-HSA-3791295 ( R-HSA-1474228 ) R-HSA-3791295 Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13 See in Reactome R-HSA-3827958 ( R-HSA-1474228 ) R-HSA-3827958 Reaction Name: E-cadherin degradation by MMP9, KLK7 See in Reactome R-HSA-3928657 ( R-HSA-3928665 ) R-HSA-3928657 Reaction Name: MMP2,9 cleave EPHB See in Reactome R-HSA-6789615 ( R-HSA-6785807 ) R-HSA-6789615 Reaction Name: Expression of STAT3-upregulated extracellular proteins See in Reactome R-HSA-6798745 ( R-HSA-6798695 ) R-HSA-6798745 Reaction Name: Exocytosis of tertiary granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-8943959 ( R-HSA-1474228 ) R-HSA-8943959 Reaction Name: MMP2, MMP9 cleave SCUBE3 See in Reactome R-HSA-9624272 ( R-HSA-9009391 ) R-HSA-9624272 Reaction Name: MMPs cleave HB-EGF See in Reactome
MONDO:0013187	F13A1	P00488	2.3.2.13	R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-140875 R-HSA-140875 Reactome Name: Common Pathway of Fibrin Clot Formation See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Immune System Hemostasis	R-HSA-140599 ( R-HSA-140875 ) R-HSA-140599 Reaction Name: factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides See in Reactome R-HSA-140847 ( R-HSA-140875 ) R-HSA-140847 Reaction Name: factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain See in Reactome R-HSA-140851 ( R-HSA-140875 ) R-HSA-140851 Reaction Name: fibrin multimer -> fibrin multimer, crosslinked + NH4+ See in Reactome R-HSA-481007 ( R-HSA-114608 ) R-HSA-481007 Reaction Name: Exocytosis of platelet alpha granule contents See in Reactome R-HSA-6785895 ( R-HSA-6785807 ) R-HSA-6785895 Reaction Name: Expression of IL4, IL13-upregulated extracellular proteins See in Reactome
MONDO:0013536	HMOX1	P09601	1.14.14.18	R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-9707587 R-HSA-9707587 Reactome Name: Regulation of HMOX1 expression and activity See in Reactome R-HSA-844456 R-HSA-844456 Reactome Name: The NLRP3 inflammasome See in Reactome R-HSA-917937 R-HSA-917937 Reactome Name: Iron uptake and transport See in Reactome R-HSA-9707564 R-HSA-9707564 Reactome Name: Cytoprotection by HMOX1 See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9609523 R-HSA-9609523 Reactome Name: Insertion of tail-anchored proteins into the endoplasmic reticulum membrane See in Reactome R-HSA-189483 R-HSA-189483 Reactome Name: Heme degradation See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome R-HSA-622312 R-HSA-622312 Reactome Name: Inflammasomes See in Reactome	Cellular responses to stimuli Protein localization Immune System Transport of small molecules Metabolism	R-HSA-1250272 ( R-HSA-844456; R-HSA-9707564 ) R-HSA-1250272 Reaction Name: TXNIP binds NLRP3 See in Reactome R-HSA-189398 ( R-HSA-189483; R-HSA-917937; R-HSA-9707564 ) R-HSA-189398 Reaction Name: HMOX1 dimer, HMOX2 cleave heme See in Reactome R-HSA-6797268 ( R-HSA-6785807 ) R-HSA-6797268 Reaction Name: Expression of HMOX1 See in Reactome R-HSA-9609860 ( R-HSA-9609523 ) R-HSA-9609860 Reaction Name: Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP See in Reactome R-HSA-9609899 ( R-HSA-9609523 ) R-HSA-9609899 Reaction Name: Tail-anchored protein:ASNA1:ADP binds WRB:CAMLG at the endoplasmic reticulum membrane See in Reactome R-HSA-9609917 ( R-HSA-9609523 ) R-HSA-9609917 Reaction Name: Tail-anchored protein:ASNA1:ADP:WRB:CAMLG dissociates yielding Tail-anchored protein in the endoplasmic reticulum membrane See in Reactome R-HSA-9609921 ( R-HSA-9609523 ) R-HSA-9609921 Reaction Name: SGTA binds Tail-anchored protein See in Reactome R-HSA-9610442 ( R-HSA-9609523 ) R-HSA-9610442 Reaction Name: Tail-anchored protein:SGTA dimer binds BAG6:GET4:UBL4A and ASNA1:ATP See in Reactome R-HSA-9707645 ( R-HSA-9707564; R-HSA-9707587; R-HSA-9707616 ) R-HSA-9707645 Reaction Name: HMOX1 gene produces HMOX1 dimer See in Reactome R-HSA-9708457 ( R-HSA-9707564; R-HSA-9707587 ) R-HSA-9708457 Reaction Name: HM13 cleaves HMOX1 dimer See in Reactome R-HSA-9708536 ( R-HSA-9707564; R-HSA-9707587 ) R-HSA-9708536 Reaction Name: HMOX1 translocates from the cytosol to the nucleoplasm See in Reactome R-HSA-9708558 ( R-HSA-9707564; R-HSA-9707587 ) R-HSA-9708558 Reaction Name: HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane See in Reactome R-HSA-9709918 ( R-HSA-9707564 ) R-HSA-9709918 Reaction Name: PTK6 phosphorylates STAT3 See in Reactome R-HSA-9759176 () R-HSA-9759176 Reaction Name: NFE2L2-dependent HMOX1 gene expression See in Reactome
MONDO:0013765	MMP3	P08254	3.4.24.17	R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome	R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Extracellular matrix organization Signal Transduction	R-HSA-1454757 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454757 Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 See in Reactome R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1454843 ( R-HSA-1474228 ) R-HSA-1454843 Reaction Name: E-cadherin degradation by MMP3, MMP7 and plasmin. See in Reactome R-HSA-1474197 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474197 Reaction Name: Collagen type II degradation by MMP1,3,8,13,PRSS2 See in Reactome R-HSA-1564120 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564120 Reaction Name: Collagen type VII degradation by MMP1,2,3 See in Reactome R-HSA-1564142 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564142 Reaction Name: Collagen type IV degradation by MMP2,3,4,9,10,12 See in Reactome R-HSA-1564179 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564179 Reaction Name: Collagen type XI degradation by MMP1,2,3,9 See in Reactome R-HSA-1564184 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564184 Reaction Name: Collagen type IX degradation by MMP3,13 See in Reactome R-HSA-1566962 ( R-HSA-1474228 ) R-HSA-1566962 Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-1566981 ( R-HSA-1474228 ) R-HSA-1566981 Reaction Name: Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS See in Reactome R-HSA-1592297 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592297 Reaction Name: Full activation of MMP1 See in Reactome R-HSA-1592314 ( R-HSA-1474228 ) R-HSA-1592314 Reaction Name: HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) See in Reactome R-HSA-1592362 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592362 Reaction Name: Activation of proMMP7 by MMP3 See in Reactome R-HSA-1592371 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592371 Reaction Name: Initial activation of proMMP3 See in Reactome R-HSA-1592436 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592436 Reaction Name: Initial activation of proMMP9 by MMPs See in Reactome R-HSA-1604690 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604690 Reaction Name: Activation of MMP9 intermediate form by MMPs See in Reactome R-HSA-1604731 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604731 Reaction Name: Autocatalytic activation of MMP3 See in Reactome R-HSA-1604752 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604752 Reaction Name: Initial activation of proMMP13 by MMP3 See in Reactome R-HSA-2168923 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168923 Reaction Name: Collagen type XVIII endostatin release See in Reactome R-HSA-2179402 ( R-HSA-2179392 ) R-HSA-2179402 Reaction Name: Active MMP3 can cleave pro-HBEGF to form active HBEGF See in Reactome R-HSA-2179413 ( R-HSA-2179392 ) R-HSA-2179413 Reaction Name: Activated PKC-alpha activate MMP3 See in Reactome R-HSA-2213200 ( R-HSA-2022090 ) R-HSA-2213200 Reaction Name: Release of endostatin-like peptides See in Reactome R-HSA-2484882 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2484882 Reaction Name: Collagen type X degradation by MMP3, 13 See in Reactome R-HSA-2514772 ( R-HSA-1474228 ) R-HSA-2514772 Reaction Name: Fibrillin-1 degradation by MMP3, CTSK, CTSL2 See in Reactome R-HSA-2533970 ( R-HSA-1474228 ) R-HSA-2533970 Reaction Name: NID1 degradation by MMP3, 7 See in Reactome R-HSA-2534248 ( R-HSA-1474228 ) R-HSA-2534248 Reaction Name: DCN (decorin) degradation by MMP2, MMP3, MMP7 See in Reactome R-HSA-3791149 ( R-HSA-1474228 ) R-HSA-3791149 Reaction Name: Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 See in Reactome R-HSA-3791295 ( R-HSA-1474228 ) R-HSA-3791295 Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13 See in Reactome R-HSA-4086205 ( R-HSA-1474228 ) R-HSA-4086205 Reaction Name: OPN (osteopontin) degradation by MMP3, MMP7 See in Reactome R-HSA-6789615 ( R-HSA-6785807 ) R-HSA-6789615 Reaction Name: Expression of STAT3-upregulated extracellular proteins See in Reactome R-HSA-9624272 ( R-HSA-9009391 ) R-HSA-9624272 Reaction Name: MMPs cleave HB-EGF See in Reactome
MONDO:0013794	JAK2	O60674	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-9027277 R-HSA-9027277 Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG) See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-9027283 R-HSA-9027283 Reactome Name: Erythropoietin activates STAT5 See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-3214858 R-HSA-3214858 Reactome Name: RMTs methylate histone arginines See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Chromatin organization Cell Cycle Hemostasis Signal Transduction	R-HSA-1168456 ( R-HSA-982772 ) R-HSA-1168456 Reaction Name: Growth hormone receptor binds Lyn See in Reactome R-HSA-8983870 ( R-HSA-8984722 ) R-HSA-8983870 Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated See in Reactome R-HSA-2671862 ( R-HSA-2586552 ) R-HSA-2671862 Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin See in Reactome R-HSA-6786070 ( R-HSA-6785807 ) R-HSA-6786070 Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950737 ( R-HSA-9020933 ) R-HSA-8950737 Reaction Name: IL23R binds JAK2 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8950423 ( R-HSA-9020591 ) R-HSA-8950423 Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-2586555 ( R-HSA-2586552 ) R-HSA-2586555 Reaction Name: JAK2 Autophosphorylates in Response to Leptin See in Reactome R-HSA-1370500 ( R-HSA-1170546 ) R-HSA-1370500 Reaction Name: PRLR binds SCF beta-TrCP complex See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-1169192 ( R-HSA-982772 ) R-HSA-1169192 Reaction Name: PTP1B dephosphorylates GHR See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-9012651 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012651 Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-6785898 ( R-HSA-6785807 ) R-HSA-6785898 Reaction Name: IL4R binds JAK2 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-2672302 ( R-HSA-2586552 ) R-HSA-2672302 Reaction Name: Phosphorylated LEPR Binds SOCS3 See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-8950063 ( R-HSA-9020591 ) R-HSA-8950063 Reaction Name: IL12RB2 binds JAK2 See in Reactome R-HSA-921155 ( R-HSA-512988 ) R-HSA-921155 Reaction Name: p-STAT5 dissociates from the receptor complex See in Reactome R-HSA-9027274 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9027274 Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-2586553 ( R-HSA-2586552 ) R-HSA-2586553 Reaction Name: JAK2 Phosphorylates LEPR See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-9006332 ( R-HSA-9006335 ) R-HSA-9006332 Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin See in Reactome R-HSA-879925 ( R-HSA-512988 ) R-HSA-879925 Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated See in Reactome R-HSA-2671855 ( R-HSA-2586552 ) R-HSA-2671855 Reaction Name: Phosphorylated LEPR Binds STAT5 See in Reactome R-HSA-1169210 ( R-HSA-982772 ) R-HSA-1169210 Reaction Name: PTP1B dephosphorylates JAK2 See in Reactome R-HSA-9027281 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027281 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-447226 ( R-HSA-9020591 ) R-HSA-447226 Reaction Name: Interleukin-12 binds Interleukin-12 receptor See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-9012654 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012654 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950583 ( R-HSA-9020933 ) R-HSA-8950583 Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9027280 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-1370505 ( R-HSA-1170546 ) R-HSA-1370505 Reaction Name: PRLR is phosphorylated at Ser-349 See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-8983876 ( R-HSA-8984722 ) R-HSA-8983876 Reaction Name: STAT4 binds IL12RB2:IL12RB2 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8950364 ( R-HSA-9020933 ) R-HSA-8950364 Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-8950128 ( R-HSA-9020591 ) R-HSA-8950128 Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor See in Reactome R-HSA-879907 ( R-HSA-512988 ) R-HSA-879907 Reaction Name: Tyrosine kinases phosphorylate the receptor See in Reactome R-HSA-1168423 ( R-HSA-982772 ) R-HSA-1168423 Reaction Name: JAK2 phosphorylation of IRS-1/2 See in Reactome R-HSA-1168768 ( R-HSA-982772 ) R-HSA-1168768 Reaction Name: JAK2 binds STAT1/3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-2671829 ( R-HSA-2586552 ) R-HSA-2671829 Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-976991 ( R-HSA-1170546 ) R-HSA-976991 Reaction Name: Prolactin receptor ligands bind the prolactin receptor See in Reactome R-HSA-1671687 ( R-HSA-1170546 ) R-HSA-1671687 Reaction Name: PRLR activation See in Reactome R-HSA-9032478 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9032478 Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-9006325 ( R-HSA-9006335 ) R-HSA-9006325 Reaction Name: EPO binds EPOR:JAK2:LYN:IRS2 See in Reactome R-HSA-9029158 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-982792 ( R-HSA-982772 ) R-HSA-982792 Reaction Name: Growth hormone receptor binds JAK2 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-9027425 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027425 Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 See in Reactome R-HSA-9024723 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024723 Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1 See in Reactome R-HSA-879930 ( R-HSA-512988 ) R-HSA-879930 Reaction Name: STAT5 is recruited by JAK2 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-1169188 ( R-HSA-982772 ) R-HSA-1169188 Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-879910 ( R-HSA-512988 ) R-HSA-879910 Reaction Name: JAK2 is phosphorylated, activated See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-2671876 ( R-HSA-2586552 ) R-HSA-2671876 Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor See in Reactome R-HSA-2671868 ( R-HSA-2586552 ) R-HSA-2671868 Reaction Name: Phosphorylated LEPR Binds STAT3 See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-879934 ( R-HSA-512988 ) R-HSA-879934 Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain See in Reactome R-HSA-6786114 ( R-HSA-6785807 ) R-HSA-6786114 Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2 See in Reactome R-HSA-913451 ( R-HSA-512988 ) R-HSA-913451 Reaction Name: IL3RB is phosphorylated on Ser-585 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-8983519 ( R-HSA-8984722 ) R-HSA-8983519 Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-913370 ( R-HSA-512988 ) R-HSA-913370 Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-2671873 ( R-HSA-2586552 ) R-HSA-2671873 Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-3215391 ( R-HSA-3214858 ) R-HSA-3215391 Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-1369080 ( R-HSA-1170546 ) R-HSA-1369080 Reaction Name: PRLR binds STAT5 See in Reactome R-HSA-1364044 ( R-HSA-1170546 ) R-HSA-1364044 Reaction Name: PRLR:JAK2 dimerizes See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-9027275 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8950269 ( R-HSA-9020933 ) R-HSA-8950269 Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor See in Reactome R-HSA-879942 ( R-HSA-512988 ) R-HSA-879942 Reaction Name: The receptor is activated See in Reactome R-HSA-8952823 ( R-HSA-9020933 ) R-HSA-8952823 Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor See in Reactome R-HSA-912757 ( R-HSA-512988 ) R-HSA-912757 Reaction Name: p-S585-IL3RB binds 14-3-3 proteins See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-2671839 ( R-HSA-2586552 ) R-HSA-2671839 Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9027273 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027273 Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-982810 ( R-HSA-1170546; R-HSA-982772 ) R-HSA-982810 Reaction Name: JAK2 phosphorylation See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8981093 ( R-HSA-9020591 ) R-HSA-8981093 Reaction Name: IL12 bound to IL12R internalises See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-1671691 ( R-HSA-1170546 ) R-HSA-1671691 Reaction Name: PRLR-bound STAT5 is phosphorylated See in Reactome R-HSA-447130 ( R-HSA-9020933 ) R-HSA-447130 Reaction Name: Interleukin-23 binds interleukin-23 receptor See in Reactome R-HSA-879937 ( R-HSA-512988 ) R-HSA-879937 Reaction Name: The common beta chain IL3RB binds JAK2 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-6785821 ( R-HSA-6785807 ) R-HSA-6785821 Reaction Name: SOCS5,(SOCS1) bind IL4RA See in Reactome R-HSA-9024726 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024726 Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-9029149 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029149 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-9006323 ( R-HSA-9006335 ) R-HSA-9006323 Reaction Name: Phospho-JAK2 phosphorylates EPOR See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-997237 ( R-HSA-983231 ) R-HSA-997237 Reaction Name: SH2B proteins bind JAK2 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-982778 ( R-HSA-982772 ) R-HSA-982778 Reaction Name: Growth hormone binds the growth hormone receptor See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-1170539 ( R-HSA-1170546 ) R-HSA-1170539 Reaction Name: Prolactin receptor is internalized See in Reactome R-HSA-9012650 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012650 Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-6786092 ( R-HSA-6785807 ) R-HSA-6786092 Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-879909 ( R-HSA-512988 ) R-HSA-879909 Reaction Name: Activation of STAT5a/b by JAK2 See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-450031 ( R-HSA-512988 ) R-HSA-450031 Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8950591 ( R-HSA-9020933 ) R-HSA-8950591 Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated See in Reactome R-HSA-9021627 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-913371 ( R-HSA-512988 ) R-HSA-913371 Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-1168894 ( R-HSA-982772 ) R-HSA-1168894 Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-2586559 ( R-HSA-2586552 ) R-HSA-2586559 Reaction Name: Leptin Binds Leptin Receptor See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-6786101 ( R-HSA-6785807 ) R-HSA-6786101 Reaction Name: IL4 binds IL4R:JAK2 See in Reactome R-HSA-1168839 ( R-HSA-982772 ) R-HSA-1168839 Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-8983878 ( R-HSA-8984722 ) R-HSA-8983878 Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-2671850 ( R-HSA-2586552 ) R-HSA-2671850 Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-1168767 ( R-HSA-982772 ) R-HSA-1168767 Reaction Name: JAK2 phosphorylates STAT1/STAT3 See in Reactome R-HSA-9029151 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029151 Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 See in Reactome R-HSA-447252 ( R-HSA-9020591 ) R-HSA-447252 Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2 See in Reactome R-HSA-1168394 ( R-HSA-982772 ) R-HSA-1168394 Reaction Name: STAT5 tyrosine phosphorylation See in Reactome R-HSA-1168393 ( R-HSA-982772 ) R-HSA-1168393 Reaction Name: STAT5 association with GHR See in Reactome R-HSA-9029155 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029155 Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-8952749 ( R-HSA-9020933 ) R-HSA-8952749 Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-1302698 ( R-HSA-1170546 ) R-HSA-1302698 Reaction Name: PRLR associates with JAK2 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-1675473 ( R-HSA-1170546 ) R-HSA-1675473 Reaction Name: SH2B binds JAK2 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1168445 ( R-HSA-982772 ) R-HSA-1168445 Reaction Name: PTP1B binds the GH receptor complex See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1364043 ( R-HSA-1170546 ) R-HSA-1364043 Reaction Name: Tyrosine phosphorylation of PRLR See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-9027373 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027373 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma See in Reactome R-HSA-8983872 ( R-HSA-8984722 ) R-HSA-8983872 Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-9029150 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029150 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-1168809 ( R-HSA-982772 ) R-HSA-1168809 Reaction Name: SOCS binding to GHR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-2671872 ( R-HSA-2586552 ) R-HSA-2671872 Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1 See in Reactome R-HSA-982807 ( R-HSA-982772 ) R-HSA-982807 Reaction Name: JAK2 phosphorylation of GHR See in Reactome R-HSA-9012657 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-982775 ( R-HSA-982772 ) R-HSA-982775 Reaction Name: Growth hormone receptor dimerizes See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-982768 ( R-HSA-982772 ) R-HSA-982768 Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change See in Reactome R-HSA-9027272 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027272 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-1168813 ( R-HSA-982772 ) R-HSA-1168813 Reaction Name: SOCS binding to JAK2 See in Reactome
MONDO:0014048	AKT1	P31749	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-450385 R-HSA-450385 Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Metabolism of RNA Vesicle-mediated transport Hemostasis	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9009391; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-432110 ( R-HSA-354192 ) R-HSA-432110 Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding See in Reactome R-HSA-450490 ( R-HSA-450385 ) R-HSA-450490 Reaction Name: Protein Kinase B/Akt phosphorylates BRF1 See in Reactome R-HSA-450499 ( R-HSA-450604 ) R-HSA-450499 Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP See in Reactome R-HSA-6790041 ( R-HSA-6785807 ) R-HSA-6790041 Reaction Name: Expression of STAT3-upregulated cytosolic proteins See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-6811504 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-6811504 Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma See in Reactome R-HSA-8848751 ( R-HSA-8849469 ) R-HSA-8848751 Reaction Name: PTK6 binds AKT1 See in Reactome R-HSA-8848758 ( R-HSA-8849469 ) R-HSA-8848758 Reaction Name: PTK6 phosphorylates AKT1 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9604328 ( R-HSA-9604323 ) R-HSA-9604328 Reaction Name: AKT1 phosphorylates NOTCH4 See in Reactome R-HSA-9624526 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0016419	AKT1	P31749	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-450385 R-HSA-450385 Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Metabolism of RNA Vesicle-mediated transport Hemostasis	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9009391; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-432110 ( R-HSA-354192 ) R-HSA-432110 Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding See in Reactome R-HSA-450490 ( R-HSA-450385 ) R-HSA-450490 Reaction Name: Protein Kinase B/Akt phosphorylates BRF1 See in Reactome R-HSA-450499 ( R-HSA-450604 ) R-HSA-450499 Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP See in Reactome R-HSA-6790041 ( R-HSA-6785807 ) R-HSA-6790041 Reaction Name: Expression of STAT3-upregulated cytosolic proteins See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-6811504 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-6811504 Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma See in Reactome R-HSA-8848751 ( R-HSA-8849469 ) R-HSA-8848751 Reaction Name: PTK6 binds AKT1 See in Reactome R-HSA-8848758 ( R-HSA-8849469 ) R-HSA-8848758 Reaction Name: PTK6 phosphorylates AKT1 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9604328 ( R-HSA-9604323 ) R-HSA-9604328 Reaction Name: AKT1 phosphorylates NOTCH4 See in Reactome R-HSA-9624526 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0016642	AKT1	P31749	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-450385 R-HSA-450385 Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Metabolism of RNA Vesicle-mediated transport Hemostasis	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9009391; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-432110 ( R-HSA-354192 ) R-HSA-432110 Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding See in Reactome R-HSA-450490 ( R-HSA-450385 ) R-HSA-450490 Reaction Name: Protein Kinase B/Akt phosphorylates BRF1 See in Reactome R-HSA-450499 ( R-HSA-450604 ) R-HSA-450499 Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP See in Reactome R-HSA-6790041 ( R-HSA-6785807 ) R-HSA-6790041 Reaction Name: Expression of STAT3-upregulated cytosolic proteins See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-6811504 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-6811504 Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma See in Reactome R-HSA-8848751 ( R-HSA-8849469 ) R-HSA-8848751 Reaction Name: PTK6 binds AKT1 See in Reactome R-HSA-8848758 ( R-HSA-8849469 ) R-HSA-8848758 Reaction Name: PTK6 phosphorylates AKT1 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9604328 ( R-HSA-9604323 ) R-HSA-9604328 Reaction Name: AKT1 phosphorylates NOTCH4 See in Reactome R-HSA-9624526 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0018298	MMP2	P08253	3.4.24.24	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Metabolism of proteins Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1454757 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454757 Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 See in Reactome R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1454791 ( R-HSA-1474228 ) R-HSA-1454791 Reaction Name: MMP2, MMP7, MMP9 bind CD44 See in Reactome R-HSA-1454822 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454822 Reaction Name: Collagen type I degradation by MMP1,2,8,13, PRSS2 See in Reactome R-HSA-1564112 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564112 Reaction Name: Collagen type VI degradation by MMP2,9,11 See in Reactome R-HSA-1564120 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564120 Reaction Name: Collagen type VII degradation by MMP1,2,3 See in Reactome R-HSA-1564142 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564142 Reaction Name: Collagen type IV degradation by MMP2,3,4,9,10,12 See in Reactome R-HSA-1564143 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564143 Reaction Name: Collagen type X degradation by MMP1,2 See in Reactome R-HSA-1564164 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564164 Reaction Name: Collagen type V degradation by MMP2,9,10 See in Reactome R-HSA-1564179 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564179 Reaction Name: Collagen type XI degradation by MMP1,2,3,9 See in Reactome R-HSA-1566962 ( R-HSA-1474228 ) R-HSA-1566962 Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-1592278 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592278 Reaction Name: Autocatalytic activation of proMMP2 See in Reactome R-HSA-1592297 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592297 Reaction Name: Full activation of MMP1 See in Reactome R-HSA-1592436 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592436 Reaction Name: Initial activation of proMMP9 by MMPs See in Reactome R-HSA-1604350 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604350 Reaction Name: MMP14:TIMP2 binds proMMP2 See in Reactome R-HSA-1604359 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604359 Reaction Name: Initial activation of proMMP2 by MMP1, 7 See in Reactome R-HSA-1604360 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604360 Reaction Name: Initial activation of proMMP2 by MMP14 See in Reactome R-HSA-1604368 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604368 Reaction Name: Autocatalytic activation of bound proMMP2 See in Reactome R-HSA-1604690 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604690 Reaction Name: Activation of MMP9 intermediate form by MMPs See in Reactome R-HSA-2485148 ( R-HSA-1474228 ) R-HSA-2485148 Reaction Name: Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 See in Reactome R-HSA-2534248 ( R-HSA-1474228 ) R-HSA-2534248 Reaction Name: DCN (decorin) degradation by MMP2, MMP3, MMP7 See in Reactome R-HSA-3791149 ( R-HSA-1474228 ) R-HSA-3791149 Reaction Name: Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 See in Reactome R-HSA-3791295 ( R-HSA-1474228 ) R-HSA-3791295 Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13 See in Reactome R-HSA-381435 ( R-HSA-381426 ) R-HSA-381435 Reaction Name: Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS See in Reactome R-HSA-3928657 ( R-HSA-3928665 ) R-HSA-3928657 Reaction Name: MMP2,9 cleave EPHB See in Reactome R-HSA-6789615 ( R-HSA-6785807 ) R-HSA-6789615 Reaction Name: Expression of STAT3-upregulated extracellular proteins See in Reactome R-HSA-8940554 ( R-HSA-1474228 ) R-HSA-8940554 Reaction Name: MMP2 cleaves OPTC See in Reactome R-HSA-8943959 ( R-HSA-1474228 ) R-HSA-8943959 Reaction Name: MMP2, MMP9 cleave SCUBE3 See in Reactome R-HSA-9624272 ( R-HSA-9009391 ) R-HSA-9624272 Reaction Name: MMPs cleave HB-EGF See in Reactome
MONDO:0018874	JAK2	O60674	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-9027277 R-HSA-9027277 Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG) See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-9027283 R-HSA-9027283 Reactome Name: Erythropoietin activates STAT5 See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-3214858 R-HSA-3214858 Reactome Name: RMTs methylate histone arginines See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Chromatin organization Cell Cycle Hemostasis Signal Transduction	R-HSA-1168456 ( R-HSA-982772 ) R-HSA-1168456 Reaction Name: Growth hormone receptor binds Lyn See in Reactome R-HSA-8983870 ( R-HSA-8984722 ) R-HSA-8983870 Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated See in Reactome R-HSA-2671862 ( R-HSA-2586552 ) R-HSA-2671862 Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin See in Reactome R-HSA-6786070 ( R-HSA-6785807 ) R-HSA-6786070 Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950737 ( R-HSA-9020933 ) R-HSA-8950737 Reaction Name: IL23R binds JAK2 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8950423 ( R-HSA-9020591 ) R-HSA-8950423 Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-2586555 ( R-HSA-2586552 ) R-HSA-2586555 Reaction Name: JAK2 Autophosphorylates in Response to Leptin See in Reactome R-HSA-1370500 ( R-HSA-1170546 ) R-HSA-1370500 Reaction Name: PRLR binds SCF beta-TrCP complex See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-1169192 ( R-HSA-982772 ) R-HSA-1169192 Reaction Name: PTP1B dephosphorylates GHR See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-9012651 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012651 Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-6785898 ( R-HSA-6785807 ) R-HSA-6785898 Reaction Name: IL4R binds JAK2 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-2672302 ( R-HSA-2586552 ) R-HSA-2672302 Reaction Name: Phosphorylated LEPR Binds SOCS3 See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-8950063 ( R-HSA-9020591 ) R-HSA-8950063 Reaction Name: IL12RB2 binds JAK2 See in Reactome R-HSA-921155 ( R-HSA-512988 ) R-HSA-921155 Reaction Name: p-STAT5 dissociates from the receptor complex See in Reactome R-HSA-9027274 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9027274 Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-2586553 ( R-HSA-2586552 ) R-HSA-2586553 Reaction Name: JAK2 Phosphorylates LEPR See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-9006332 ( R-HSA-9006335 ) R-HSA-9006332 Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin See in Reactome R-HSA-879925 ( R-HSA-512988 ) R-HSA-879925 Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated See in Reactome R-HSA-2671855 ( R-HSA-2586552 ) R-HSA-2671855 Reaction Name: Phosphorylated LEPR Binds STAT5 See in Reactome R-HSA-1169210 ( R-HSA-982772 ) R-HSA-1169210 Reaction Name: PTP1B dephosphorylates JAK2 See in Reactome R-HSA-9027281 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027281 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-447226 ( R-HSA-9020591 ) R-HSA-447226 Reaction Name: Interleukin-12 binds Interleukin-12 receptor See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-9012654 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012654 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950583 ( R-HSA-9020933 ) R-HSA-8950583 Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9027280 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-1370505 ( R-HSA-1170546 ) R-HSA-1370505 Reaction Name: PRLR is phosphorylated at Ser-349 See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-8983876 ( R-HSA-8984722 ) R-HSA-8983876 Reaction Name: STAT4 binds IL12RB2:IL12RB2 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8950364 ( R-HSA-9020933 ) R-HSA-8950364 Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-8950128 ( R-HSA-9020591 ) R-HSA-8950128 Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor See in Reactome R-HSA-879907 ( R-HSA-512988 ) R-HSA-879907 Reaction Name: Tyrosine kinases phosphorylate the receptor See in Reactome R-HSA-1168423 ( R-HSA-982772 ) R-HSA-1168423 Reaction Name: JAK2 phosphorylation of IRS-1/2 See in Reactome R-HSA-1168768 ( R-HSA-982772 ) R-HSA-1168768 Reaction Name: JAK2 binds STAT1/3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-2671829 ( R-HSA-2586552 ) R-HSA-2671829 Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-976991 ( R-HSA-1170546 ) R-HSA-976991 Reaction Name: Prolactin receptor ligands bind the prolactin receptor See in Reactome R-HSA-1671687 ( R-HSA-1170546 ) R-HSA-1671687 Reaction Name: PRLR activation See in Reactome R-HSA-9032478 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9032478 Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-9006325 ( R-HSA-9006335 ) R-HSA-9006325 Reaction Name: EPO binds EPOR:JAK2:LYN:IRS2 See in Reactome R-HSA-9029158 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-982792 ( R-HSA-982772 ) R-HSA-982792 Reaction Name: Growth hormone receptor binds JAK2 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-9027425 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027425 Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 See in Reactome R-HSA-9024723 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024723 Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1 See in Reactome R-HSA-879930 ( R-HSA-512988 ) R-HSA-879930 Reaction Name: STAT5 is recruited by JAK2 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-1169188 ( R-HSA-982772 ) R-HSA-1169188 Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-879910 ( R-HSA-512988 ) R-HSA-879910 Reaction Name: JAK2 is phosphorylated, activated See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-2671876 ( R-HSA-2586552 ) R-HSA-2671876 Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor See in Reactome R-HSA-2671868 ( R-HSA-2586552 ) R-HSA-2671868 Reaction Name: Phosphorylated LEPR Binds STAT3 See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-879934 ( R-HSA-512988 ) R-HSA-879934 Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain See in Reactome R-HSA-6786114 ( R-HSA-6785807 ) R-HSA-6786114 Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2 See in Reactome R-HSA-913451 ( R-HSA-512988 ) R-HSA-913451 Reaction Name: IL3RB is phosphorylated on Ser-585 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-8983519 ( R-HSA-8984722 ) R-HSA-8983519 Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-913370 ( R-HSA-512988 ) R-HSA-913370 Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-2671873 ( R-HSA-2586552 ) R-HSA-2671873 Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-3215391 ( R-HSA-3214858 ) R-HSA-3215391 Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-1369080 ( R-HSA-1170546 ) R-HSA-1369080 Reaction Name: PRLR binds STAT5 See in Reactome R-HSA-1364044 ( R-HSA-1170546 ) R-HSA-1364044 Reaction Name: PRLR:JAK2 dimerizes See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-9027275 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8950269 ( R-HSA-9020933 ) R-HSA-8950269 Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor See in Reactome R-HSA-879942 ( R-HSA-512988 ) R-HSA-879942 Reaction Name: The receptor is activated See in Reactome R-HSA-8952823 ( R-HSA-9020933 ) R-HSA-8952823 Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor See in Reactome R-HSA-912757 ( R-HSA-512988 ) R-HSA-912757 Reaction Name: p-S585-IL3RB binds 14-3-3 proteins See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-2671839 ( R-HSA-2586552 ) R-HSA-2671839 Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9027273 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027273 Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-982810 ( R-HSA-1170546; R-HSA-982772 ) R-HSA-982810 Reaction Name: JAK2 phosphorylation See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8981093 ( R-HSA-9020591 ) R-HSA-8981093 Reaction Name: IL12 bound to IL12R internalises See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-1671691 ( R-HSA-1170546 ) R-HSA-1671691 Reaction Name: PRLR-bound STAT5 is phosphorylated See in Reactome R-HSA-447130 ( R-HSA-9020933 ) R-HSA-447130 Reaction Name: Interleukin-23 binds interleukin-23 receptor See in Reactome R-HSA-879937 ( R-HSA-512988 ) R-HSA-879937 Reaction Name: The common beta chain IL3RB binds JAK2 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-6785821 ( R-HSA-6785807 ) R-HSA-6785821 Reaction Name: SOCS5,(SOCS1) bind IL4RA See in Reactome R-HSA-9024726 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9024726 Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-9029149 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029149 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-9006323 ( R-HSA-9006335 ) R-HSA-9006323 Reaction Name: Phospho-JAK2 phosphorylates EPOR See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-997237 ( R-HSA-983231 ) R-HSA-997237 Reaction Name: SH2B proteins bind JAK2 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-982778 ( R-HSA-982772 ) R-HSA-982778 Reaction Name: Growth hormone binds the growth hormone receptor See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-1170539 ( R-HSA-1170546 ) R-HSA-1170539 Reaction Name: Prolactin receptor is internalized See in Reactome R-HSA-9012650 ( R-HSA-9006335; R-HSA-9027283 ) R-HSA-9012650 Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-6786092 ( R-HSA-6785807 ) R-HSA-6786092 Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-879909 ( R-HSA-512988 ) R-HSA-879909 Reaction Name: Activation of STAT5a/b by JAK2 See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-450031 ( R-HSA-512988 ) R-HSA-450031 Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8950591 ( R-HSA-9020933 ) R-HSA-8950591 Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated See in Reactome R-HSA-9021627 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-913371 ( R-HSA-512988 ) R-HSA-913371 Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-1168894 ( R-HSA-982772 ) R-HSA-1168894 Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-2586559 ( R-HSA-2586552 ) R-HSA-2586559 Reaction Name: Leptin Binds Leptin Receptor See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-6786101 ( R-HSA-6785807 ) R-HSA-6786101 Reaction Name: IL4 binds IL4R:JAK2 See in Reactome R-HSA-1168839 ( R-HSA-982772 ) R-HSA-1168839 Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-8983878 ( R-HSA-8984722 ) R-HSA-8983878 Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-2671850 ( R-HSA-2586552 ) R-HSA-2671850 Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-1168767 ( R-HSA-982772 ) R-HSA-1168767 Reaction Name: JAK2 phosphorylates STAT1/STAT3 See in Reactome R-HSA-9029151 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029151 Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 See in Reactome R-HSA-447252 ( R-HSA-9020591 ) R-HSA-447252 Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2 See in Reactome R-HSA-1168394 ( R-HSA-982772 ) R-HSA-1168394 Reaction Name: STAT5 tyrosine phosphorylation See in Reactome R-HSA-1168393 ( R-HSA-982772 ) R-HSA-1168393 Reaction Name: STAT5 association with GHR See in Reactome R-HSA-9029155 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029155 Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-8952749 ( R-HSA-9020933 ) R-HSA-8952749 Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-1302698 ( R-HSA-1170546 ) R-HSA-1302698 Reaction Name: PRLR associates with JAK2 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-1675473 ( R-HSA-1170546 ) R-HSA-1675473 Reaction Name: SH2B binds JAK2 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1168445 ( R-HSA-982772 ) R-HSA-1168445 Reaction Name: PTP1B binds the GH receptor complex See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1364043 ( R-HSA-1170546 ) R-HSA-1364043 Reaction Name: Tyrosine phosphorylation of PRLR See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-9027373 ( R-HSA-9006335; R-HSA-9027277 ) R-HSA-9027373 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma See in Reactome R-HSA-8983872 ( R-HSA-8984722 ) R-HSA-8983872 Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-9029150 ( R-HSA-9006335; R-HSA-9027284 ) R-HSA-9029150 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-1168809 ( R-HSA-982772 ) R-HSA-1168809 Reaction Name: SOCS binding to GHR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-2671872 ( R-HSA-2586552 ) R-HSA-2671872 Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1 See in Reactome R-HSA-982807 ( R-HSA-982772 ) R-HSA-982807 Reaction Name: JAK2 phosphorylation of GHR See in Reactome R-HSA-9012657 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-982775 ( R-HSA-982772 ) R-HSA-982775 Reaction Name: Growth hormone receptor dimerizes See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-982768 ( R-HSA-982772 ) R-HSA-982768 Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change See in Reactome R-HSA-9027272 ( R-HSA-9006335; R-HSA-9027276 ) R-HSA-9027272 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-1168813 ( R-HSA-982772 ) R-HSA-1168813 Reaction Name: SOCS binding to JAK2 See in Reactome
MONDO:0020526	JAK1	P23458	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-1169408 R-HSA-1169408 Reactome Name: ISG15 antiviral mechanism See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020958 R-HSA-9020958 Reactome Name: Interleukin-21 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-1266695 R-HSA-1266695 Reactome Name: Interleukin-7 signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-8985947 R-HSA-8985947 Reactome Name: Interleukin-9 signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-8983432 R-HSA-8983432 Reactome Name: Interleukin-15 signaling See in Reactome R-HSA-6783783 R-HSA-6783783 Reactome Name: Interleukin-10 signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-449836 R-HSA-449836 Reactome Name: Other interleukin signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-1169410 R-HSA-1169410 Reactome Name: Antiviral mechanism by IFN-stimulated genes See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Signal Transduction	R-HSA-9677585 ( R-HSA-9674555 ) R-HSA-9677585 Reaction Name: CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 See in Reactome R-HSA-909720 ( R-HSA-909733 ) R-HSA-909720 Reaction Name: IFN alpha/beta binds to IFNAR2 See in Reactome R-HSA-8987266 ( R-HSA-8854691 ) R-HSA-8987266 Reaction Name: IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 See in Reactome R-HSA-448708 ( R-HSA-8854691 ) R-HSA-448708 Reaction Name: IL24 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-8983335 ( R-HSA-8983432 ) R-HSA-8983335 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome See in Reactome R-HSA-8985988 ( R-HSA-8985947 ) R-HSA-8985988 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-6784319 ( R-HSA-6783783 ) R-HSA-6784319 Reaction Name: JAK1,TYK2 phosphorylate JAK1,TYK2 See in Reactome R-HSA-8987105 ( R-HSA-8854691 ) R-HSA-8987105 Reaction Name: IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-451900 ( R-HSA-9020558 ) R-HSA-451900 Reaction Name: IL2RB binds JAK1 See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-8987015 ( R-HSA-8854691 ) R-HSA-8987015 Reaction Name: IL20 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-452091 ( R-HSA-9020558 ) R-HSA-452091 Reaction Name: Phosphorylation of IL2RB Y338 enables SHC recruitment See in Reactome R-HSA-8854645 ( R-HSA-8854691 ) R-HSA-8854645 Reaction Name: IL22:IL22RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-9006873 ( R-HSA-9020958 ) R-HSA-9006873 Reaction Name: IL21 receptor STAT binding See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-9025969 ( R-HSA-1266695 ) R-HSA-9025969 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 See in Reactome R-HSA-9005980 ( R-HSA-9020958 ) R-HSA-9005980 Reaction Name: IL21 binds IL21R:JAK1 See in Reactome R-HSA-912680 ( R-HSA-909733; R-HSA-912694 ) R-HSA-912680 Reaction Name: Inhibition of JAK kinase activity by SOCS1/3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-448661 ( R-HSA-449836; R-HSA-8854691 ) R-HSA-448661 Reaction Name: IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-449811 ( R-HSA-6783783 ) R-HSA-449811 Reaction Name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-8987270 ( R-HSA-8854691 ) R-HSA-8987270 Reaction Name: p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9674558 ( R-HSA-9674555 ) R-HSA-9674558 Reaction Name: p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 See in Reactome R-HSA-8982165 ( R-HSA-8854691 ) R-HSA-8982165 Reaction Name: IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 See in Reactome R-HSA-9678935 ( R-HSA-909733 ) R-HSA-9678935 Reaction Name: IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors See in Reactome R-HSA-8983374 ( R-HSA-8983432 ) R-HSA-8983374 Reaction Name: p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 See in Reactome R-HSA-8987080 ( R-HSA-8854691 ) R-HSA-8987080 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8987039 ( R-HSA-8854691 ) R-HSA-8987039 Reaction Name: JAK1 binds IL20RA See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-8986480 ( R-HSA-8854691 ) R-HSA-8986480 Reaction Name: IL26:IL20RA:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-8985929 ( R-HSA-8985947 ) R-HSA-8985929 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-452100 ( R-HSA-9020558 ) R-HSA-452100 Reaction Name: SHC1 bound to IL2 receptor is phosphorylated See in Reactome R-HSA-8983425 ( R-HSA-8983432 ) R-HSA-8983425 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 See in Reactome R-HSA-6784791 ( R-HSA-6783783 ) R-HSA-6784791 Reaction Name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8987040 ( R-HSA-8854691 ) R-HSA-8987040 Reaction Name: IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 See in Reactome R-HSA-909718 ( R-HSA-909733 ) R-HSA-909718 Reaction Name: Formation of p-STAT1 homodimer See in Reactome R-HSA-449803 ( R-HSA-6783783 ) R-HSA-449803 Reaction Name: IL10 dimer binds IL10RA:JAK1 See in Reactome R-HSA-8987161 ( R-HSA-8854691 ) R-HSA-8987161 Reaction Name: p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 See in Reactome R-HSA-8987129 ( R-HSA-8854691 ) R-HSA-8987129 Reaction Name: JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-6784006 ( R-HSA-6783783 ) R-HSA-6784006 Reaction Name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 See in Reactome R-HSA-452108 ( R-HSA-9020558 ) R-HSA-452108 Reaction Name: Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-909729 ( R-HSA-909733 ) R-HSA-909729 Reaction Name: Activation of JAK kinases See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-8983371 ( R-HSA-8983432 ) R-HSA-8983371 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome R-HSA-997314 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997314 Reaction Name: Dephosphorylation of JAK1 by SHP1 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-6784324 ( R-HSA-6783783 ) R-HSA-6784324 Reaction Name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA See in Reactome R-HSA-450063 ( R-HSA-9020558 ) R-HSA-450063 Reaction Name: Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit See in Reactome R-HSA-8982162 ( R-HSA-8854691 ) R-HSA-8982162 Reaction Name: p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB See in Reactome R-HSA-8963734 ( R-HSA-8985947 ) R-HSA-8963734 Reaction Name: IL9 binds IL9R:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-1169406 ( R-HSA-1169408 ) R-HSA-1169406 Reaction Name: ISGylation of host proteins See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-8987120 ( R-HSA-8854691 ) R-HSA-8987120 Reaction Name: JAK1 binds IFNLR1 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-452097 ( R-HSA-9020558 ) R-HSA-452097 Reaction Name: Recruited STAT5 is phosphorylated See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8983298 ( R-HSA-8983432 ) R-HSA-8983298 Reaction Name: IL15 binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-448480 ( R-HSA-8854691 ) R-HSA-448480 Reaction Name: IL22 binds IL22RA1:JAK1 receptor complex See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-909730 ( R-HSA-909733 ) R-HSA-909730 Reaction Name: Phosphorylation of INFAR1 by TYK2 See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-919404 ( R-HSA-9020558 ) R-HSA-919404 Reaction Name: Phosphorylated STAT5 is released See in Reactome R-HSA-8986972 ( R-HSA-8854691 ) R-HSA-8986972 Reaction Name: IL24 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8983424 ( R-HSA-8983432 ) R-HSA-8983424 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-9009700 ( R-HSA-8983432 ) R-HSA-9009700 Reaction Name: IL2RB and IL2RG are phosphorylated See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-8983394 ( R-HSA-8983432 ) R-HSA-8983394 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 See in Reactome R-HSA-9677579 ( R-HSA-9674555 ) R-HSA-9677579 Reaction Name: CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN See in Reactome R-HSA-8986994 ( R-HSA-8854691 ) R-HSA-8986994 Reaction Name: IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-449958 ( R-HSA-1266695 ) R-HSA-449958 Reaction Name: IL7:IL7R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-8950716 ( R-HSA-9020956 ) R-HSA-8950716 Reaction Name: IL27RA binds JAK1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-1264832 ( R-HSA-1266695 ) R-HSA-1264832 Reaction Name: JAK1 binds IL7R See in Reactome R-HSA-8987202 ( R-HSA-8854691 ) R-HSA-8987202 Reaction Name: IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-909724 ( R-HSA-909733 ) R-HSA-909724 Reaction Name: Recruitment of IFNAR1 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-8987097 ( R-HSA-8854691 ) R-HSA-8987097 Reaction Name: IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 See in Reactome R-HSA-997311 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997311 Reaction Name: Dephosphorylation of TYK2 by PTP1B See in Reactome R-HSA-8987042 ( R-HSA-8854691 ) R-HSA-8987042 Reaction Name: IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-448744 ( R-HSA-8854691 ) R-HSA-448744 Reaction Name: IL20RA binds IL20RB See in Reactome R-HSA-8986446 ( R-HSA-8854691 ) R-HSA-8986446 Reaction Name: IL26 binds IL20RA:JAK1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-8985900 ( R-HSA-8985947 ) R-HSA-8985900 Reaction Name: p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 See in Reactome R-HSA-1678841 ( R-HSA-1169408 ) R-HSA-1678841 Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-8987012 ( R-HSA-8854691 ) R-HSA-8987012 Reaction Name: IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-909719 ( R-HSA-909733 ) R-HSA-909719 Reaction Name: Recruitment of STAT2 to p-IFNAR1 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-9006844 ( R-HSA-9020958 ) R-HSA-9006844 Reaction Name: IL21:IL21R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-909732 ( R-HSA-909733 ) R-HSA-909732 Reaction Name: Phosphorylation of STAT2 See in Reactome R-HSA-9009227 ( R-HSA-8854691 ) R-HSA-9009227 Reaction Name: IL20 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-6785165 ( R-HSA-1266695 ) R-HSA-6785165 Reaction Name: p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-1295540 ( R-HSA-1266695 ) R-HSA-1295540 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-8983063 ( R-HSA-1266695 ) R-HSA-8983063 Reaction Name: JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated See in Reactome R-HSA-8982163 ( R-HSA-8854691 ) R-HSA-8982163 Reaction Name: IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-450027 ( R-HSA-9020558 ) R-HSA-450027 Reaction Name: Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-8987255 ( R-HSA-8854691 ) R-HSA-8987255 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 See in Reactome R-HSA-1295519 ( R-HSA-1266695 ) R-HSA-1295519 Reaction Name: IL7R is phosphorylated on Y499 See in Reactome R-HSA-448728 ( R-HSA-8854691 ) R-HSA-448728 Reaction Name: IL19 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8987084 ( R-HSA-8854691 ) R-HSA-8987084 Reaction Name: IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-8983003 ( R-HSA-1266695 ) R-HSA-8983003 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 See in Reactome R-HSA-449978 ( R-HSA-1266695 ) R-HSA-449978 Reaction Name: IL7 binds IL7R:JAK1 See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9011748 ( R-HSA-8985947 ) R-HSA-9011748 Reaction Name: IL9R binds JAK1 See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-6784323 ( R-HSA-6783783 ) R-HSA-6784323 Reaction Name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-449115 ( R-HSA-8983432 ) R-HSA-449115 Reaction Name: IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987063 ( R-HSA-8854691 ) R-HSA-8987063 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 See in Reactome R-HSA-8987043 ( R-HSA-8854691 ) R-HSA-8987043 Reaction Name: IL22RA1 binds JAK1 See in Reactome R-HSA-8983384 ( R-HSA-8983432 ) R-HSA-8983384 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-9006850 ( R-HSA-9020958 ) R-HSA-9006850 Reaction Name: IL21 receptor JAK phosphorylation See in Reactome R-HSA-8987150 ( R-HSA-8854691 ) R-HSA-8987150 Reaction Name: IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-8983300 ( R-HSA-8983432 ) R-HSA-8983300 Reaction Name: IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-8987096 ( R-HSA-8854691 ) R-HSA-8987096 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-8986995 ( R-HSA-8854691 ) R-HSA-8986995 Reaction Name: IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA See in Reactome R-HSA-8986985 ( R-HSA-8854691 ) R-HSA-8986985 Reaction Name: IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-452122 ( R-HSA-9020558 ) R-HSA-452122 Reaction Name: JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB See in Reactome R-HSA-909722 ( R-HSA-909733 ) R-HSA-909722 Reaction Name: Release of p-STAT2:p-STAT1 dimer See in Reactome R-HSA-8987033 ( R-HSA-8854691 ) R-HSA-8987033 Reaction Name: p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-8983309 ( R-HSA-8983432 ) R-HSA-8983309 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 See in Reactome R-HSA-448660 ( R-HSA-6788467 ) R-HSA-448660 Reaction Name: IL31:IL31RA:JAK1 binds OSMR:JAK1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-8985973 ( R-HSA-8985947 ) R-HSA-8985973 Reaction Name: IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 See in Reactome R-HSA-451942 ( R-HSA-9020558 ) R-HSA-451942 Reaction Name: Within the IL-2R complex JAK3 phosphorylates JAK1 See in Reactome R-HSA-9006870 ( R-HSA-9020958 ) R-HSA-9006870 Reaction Name: IL21 receptor STAT phosphorylation See in Reactome R-HSA-8985914 ( R-HSA-8985947 ) R-HSA-8985914 Reaction Name: IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-8983299 ( R-HSA-8983432 ) R-HSA-8983299 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-8983378 ( R-HSA-8983432 ) R-HSA-8983378 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-8987230 ( R-HSA-8854691 ) R-HSA-8987230 Reaction Name: p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1295516 ( R-HSA-1266695 ) R-HSA-1295516 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-9674546 ( R-HSA-9674555 ) R-HSA-9674546 Reaction Name: CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1 See in Reactome
MONDO:0033558	JAK1	P23458	2.7.10.2	R-HSA-8984722 R-HSA-8984722 Reactome Name: Interleukin-35 Signalling See in Reactome R-HSA-1169408 R-HSA-1169408 Reactome Name: ISG15 antiviral mechanism See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-9020956 R-HSA-9020956 Reactome Name: Interleukin-27 signaling See in Reactome R-HSA-9020958 R-HSA-9020958 Reactome Name: Interleukin-21 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-1266695 R-HSA-1266695 Reactome Name: Interleukin-7 signaling See in Reactome R-HSA-6788467 R-HSA-6788467 Reactome Name: IL-6-type cytokine receptor ligand interactions See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-8985947 R-HSA-8985947 Reactome Name: Interleukin-9 signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-8983432 R-HSA-8983432 Reactome Name: Interleukin-15 signaling See in Reactome R-HSA-6783783 R-HSA-6783783 Reactome Name: Interleukin-10 signaling See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-449836 R-HSA-449836 Reactome Name: Other interleukin signaling See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-1169410 R-HSA-1169410 Reactome Name: Antiviral mechanism by IFN-stimulated genes See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Immune System Signal Transduction	R-HSA-9677585 ( R-HSA-9674555 ) R-HSA-9677585 Reaction Name: CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 See in Reactome R-HSA-909720 ( R-HSA-909733 ) R-HSA-909720 Reaction Name: IFN alpha/beta binds to IFNAR2 See in Reactome R-HSA-8987266 ( R-HSA-8854691 ) R-HSA-8987266 Reaction Name: IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 See in Reactome R-HSA-448708 ( R-HSA-8854691 ) R-HSA-448708 Reaction Name: IL24 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-8983335 ( R-HSA-8983432 ) R-HSA-8983335 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome See in Reactome R-HSA-8985988 ( R-HSA-8985947 ) R-HSA-8985988 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 See in Reactome R-HSA-1067688 ( R-HSA-1059683 ) R-HSA-1067688 Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-6784319 ( R-HSA-6783783 ) R-HSA-6784319 Reaction Name: JAK1,TYK2 phosphorylate JAK1,TYK2 See in Reactome R-HSA-8987105 ( R-HSA-8854691 ) R-HSA-8987105 Reaction Name: IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-448427 ( R-HSA-9020956 ) R-HSA-448427 Reaction Name: Interleukin-27 binds Interleukin-27 receptor See in Reactome R-HSA-451900 ( R-HSA-9020558 ) R-HSA-451900 Reaction Name: IL2RB binds JAK1 See in Reactome R-HSA-873922 ( R-HSA-877300 ) R-HSA-873922 Reaction Name: Phosphorylation of STAT1 by JAK kinases See in Reactome R-HSA-8987104 ( R-HSA-8854691 ) R-HSA-8987104 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 See in Reactome R-HSA-8987015 ( R-HSA-8854691 ) R-HSA-8987015 Reaction Name: IL20 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-6786096 ( R-HSA-6785807 ) R-HSA-6786096 Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated See in Reactome R-HSA-452091 ( R-HSA-9020558 ) R-HSA-452091 Reaction Name: Phosphorylation of IL2RB Y338 enables SHC recruitment See in Reactome R-HSA-8854645 ( R-HSA-8854691 ) R-HSA-8854645 Reaction Name: IL22:IL22RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-877308 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-9006873 ( R-HSA-9020958 ) R-HSA-9006873 Reaction Name: IL21 receptor STAT binding See in Reactome R-HSA-873924 ( R-HSA-877300 ) R-HSA-873924 Reaction Name: Phosphorylation of IFNGR1 by JAK kinases See in Reactome R-HSA-9025969 ( R-HSA-1266695 ) R-HSA-9025969 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 See in Reactome R-HSA-9005980 ( R-HSA-9020958 ) R-HSA-9005980 Reaction Name: IL21 binds IL21R:JAK1 See in Reactome R-HSA-912680 ( R-HSA-909733; R-HSA-912694 ) R-HSA-912680 Reaction Name: Inhibition of JAK kinase activity by SOCS1/3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-6783552 ( R-HSA-6788467 ) R-HSA-6783552 Reaction Name: OSM binds LIFR:JAKs,OSMR:JAKs See in Reactome R-HSA-6786110 ( R-HSA-6785807 ) R-HSA-6786110 Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II See in Reactome R-HSA-448661 ( R-HSA-449836; R-HSA-8854691 ) R-HSA-448661 Reaction Name: IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 See in Reactome R-HSA-1112514 ( R-HSA-1059683 ) R-HSA-1112514 Reaction Name: JAK activation See in Reactome R-HSA-449811 ( R-HSA-6783783 ) R-HSA-449811 Reaction Name: IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-1112510 ( R-HSA-1059683 ) R-HSA-1112510 Reaction Name: IL6ST is tyrosine phosphorylated See in Reactome R-HSA-8987270 ( R-HSA-8854691 ) R-HSA-8987270 Reaction Name: p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 See in Reactome R-HSA-8950354 ( R-HSA-9020591 ) R-HSA-8950354 Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction See in Reactome R-HSA-8950210 ( R-HSA-9020956 ) R-HSA-8950210 Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor See in Reactome R-HSA-9674558 ( R-HSA-9674555 ) R-HSA-9674558 Reaction Name: p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 See in Reactome R-HSA-8982165 ( R-HSA-8854691 ) R-HSA-8982165 Reaction Name: IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 See in Reactome R-HSA-9678935 ( R-HSA-909733 ) R-HSA-9678935 Reaction Name: IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors See in Reactome R-HSA-8983374 ( R-HSA-8983432 ) R-HSA-8983374 Reaction Name: p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 See in Reactome R-HSA-8987080 ( R-HSA-8854691 ) R-HSA-8987080 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 See in Reactome R-HSA-6783530 ( R-HSA-6788467 ) R-HSA-6783530 Reaction Name: gp130:JAKs bind CNTFR See in Reactome R-HSA-8987039 ( R-HSA-8854691 ) R-HSA-8987039 Reaction Name: JAK1 binds IL20RA See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-8986480 ( R-HSA-8854691 ) R-HSA-8986480 Reaction Name: IL26:IL20RA:JAK1 binds IL10RB:TYK2 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-8985929 ( R-HSA-8985947 ) R-HSA-8985929 Reaction Name: IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-452100 ( R-HSA-9020558 ) R-HSA-452100 Reaction Name: SHC1 bound to IL2 receptor is phosphorylated See in Reactome R-HSA-8983425 ( R-HSA-8983432 ) R-HSA-8983425 Reaction Name: IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 See in Reactome R-HSA-6784791 ( R-HSA-6783783 ) R-HSA-6784791 Reaction Name: p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-6783681 ( R-HSA-6788467 ) R-HSA-6783681 Reaction Name: LIF binds LIFR See in Reactome R-HSA-8987220 ( R-HSA-8854691 ) R-HSA-8987220 Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 See in Reactome R-HSA-8987040 ( R-HSA-8854691 ) R-HSA-8987040 Reaction Name: IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 See in Reactome R-HSA-909718 ( R-HSA-909733 ) R-HSA-909718 Reaction Name: Formation of p-STAT1 homodimer See in Reactome R-HSA-449803 ( R-HSA-6783783 ) R-HSA-449803 Reaction Name: IL10 dimer binds IL10RA:JAK1 See in Reactome R-HSA-8987161 ( R-HSA-8854691 ) R-HSA-8987161 Reaction Name: p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 See in Reactome R-HSA-8987129 ( R-HSA-8854691 ) R-HSA-8987129 Reaction Name: JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated See in Reactome R-HSA-8984014 ( R-HSA-8984722 ) R-HSA-8984014 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 See in Reactome R-HSA-6784006 ( R-HSA-6783783 ) R-HSA-6784006 Reaction Name: STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 See in Reactome R-HSA-452108 ( R-HSA-9020558 ) R-HSA-452108 Reaction Name: Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-909729 ( R-HSA-909733 ) R-HSA-909729 Reaction Name: Activation of JAK kinases See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-6786124 ( R-HSA-6785807 ) R-HSA-6786124 Reaction Name: STAT3,STAT6 bind p-Y-IL4R See in Reactome R-HSA-8983371 ( R-HSA-8983432 ) R-HSA-8983371 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome R-HSA-997314 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997314 Reaction Name: Dephosphorylation of JAK1 by SHP1 See in Reactome R-HSA-873918 ( R-HSA-877300 ) R-HSA-873918 Reaction Name: Transphosphorylation of JAK1 See in Reactome R-HSA-8950518 ( R-HSA-9020956 ) R-HSA-8950518 Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex See in Reactome R-HSA-8983841 ( R-HSA-8984722 ) R-HSA-8983841 Reaction Name: STAT1 associates with IL6ST:IL6ST See in Reactome R-HSA-8950757 ( R-HSA-9020591 ) R-HSA-8950757 Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated See in Reactome R-HSA-877269 ( R-HSA-877300; R-HSA-877312 ) R-HSA-877269 Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2 See in Reactome R-HSA-8983834 ( R-HSA-8984722 ) R-HSA-8983834 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated See in Reactome R-HSA-6784324 ( R-HSA-6783783 ) R-HSA-6784324 Reaction Name: p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA See in Reactome R-HSA-450063 ( R-HSA-9020558 ) R-HSA-450063 Reaction Name: Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit See in Reactome R-HSA-8982162 ( R-HSA-8854691 ) R-HSA-8982162 Reaction Name: p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB See in Reactome R-HSA-8963734 ( R-HSA-8985947 ) R-HSA-8963734 Reaction Name: IL9 binds IL9R:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-6783556 ( R-HSA-6788467 ) R-HSA-6783556 Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR See in Reactome R-HSA-1169406 ( R-HSA-1169408 ) R-HSA-1169406 Reaction Name: ISGylation of host proteins See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-8987120 ( R-HSA-8854691 ) R-HSA-8987120 Reaction Name: JAK1 binds IFNLR1 See in Reactome R-HSA-8983518 ( R-HSA-8984722 ) R-HSA-8983518 Reaction Name: IL35 binds IL6ST:IL6ST receptor See in Reactome R-HSA-452097 ( R-HSA-9020558 ) R-HSA-452097 Reaction Name: Recruited STAT5 is phosphorylated See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8983298 ( R-HSA-8983432 ) R-HSA-8983298 Reaction Name: IL15 binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-5696482 ( R-HSA-6788467 ) R-HSA-5696482 Reaction Name: CTF1 binds LIFR:JAKs See in Reactome R-HSA-448480 ( R-HSA-8854691 ) R-HSA-448480 Reaction Name: IL22 binds IL22RA1:JAK1 receptor complex See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-909730 ( R-HSA-909733 ) R-HSA-909730 Reaction Name: Phosphorylation of INFAR1 by TYK2 See in Reactome R-HSA-1112727 ( R-HSA-1059683 ) R-HSA-1112727 Reaction Name: Serine phosphorylation of STATs See in Reactome R-HSA-919404 ( R-HSA-9020558 ) R-HSA-919404 Reaction Name: Phosphorylated STAT5 is released See in Reactome R-HSA-8986972 ( R-HSA-8854691 ) R-HSA-8986972 Reaction Name: IL24 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-8950441 ( R-HSA-9020956 ) R-HSA-8950441 Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor See in Reactome R-HSA-8983424 ( R-HSA-8983432 ) R-HSA-8983424 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 See in Reactome R-HSA-449976 ( R-HSA-6788467 ) R-HSA-449976 Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) See in Reactome R-HSA-8950448 ( R-HSA-9020591 ) R-HSA-8950448 Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex See in Reactome R-HSA-9009700 ( R-HSA-8983432 ) R-HSA-9009700 Reaction Name: IL2RB and IL2RG are phosphorylated See in Reactome R-HSA-1112565 ( R-HSA-1059683 ) R-HSA-1112565 Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3 See in Reactome R-HSA-8983394 ( R-HSA-8983432 ) R-HSA-8983394 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 See in Reactome R-HSA-9677579 ( R-HSA-9674555 ) R-HSA-9677579 Reaction Name: CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN See in Reactome R-HSA-8986994 ( R-HSA-8854691 ) R-HSA-8986994 Reaction Name: IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 See in Reactome R-HSA-1067646 ( R-HSA-1059683; R-HSA-9020956 ) R-HSA-1067646 Reaction Name: JAK1,JAK2,(TYK2) bind IL6ST See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-449958 ( R-HSA-1266695 ) R-HSA-449958 Reaction Name: IL7:IL7R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-8950716 ( R-HSA-9020956 ) R-HSA-8950716 Reaction Name: IL27RA binds JAK1 See in Reactome R-HSA-1112604 ( R-HSA-1059683 ) R-HSA-1112604 Reaction Name: Phosphorylated STATs are released See in Reactome R-HSA-8984023 ( R-HSA-8984722 ) R-HSA-8984023 Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor See in Reactome R-HSA-9678561 ( R-HSA-877300 ) R-HSA-9678561 Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors See in Reactome R-HSA-1264832 ( R-HSA-1266695 ) R-HSA-1264832 Reaction Name: JAK1 binds IL7R See in Reactome R-HSA-8987202 ( R-HSA-8854691 ) R-HSA-8987202 Reaction Name: IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-909724 ( R-HSA-909733 ) R-HSA-909724 Reaction Name: Recruitment of IFNAR1 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-6786050 ( R-HSA-6785807 ) R-HSA-6786050 Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated See in Reactome R-HSA-8987097 ( R-HSA-8854691 ) R-HSA-8987097 Reaction Name: IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 See in Reactome R-HSA-997311 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997311 Reaction Name: Dephosphorylation of TYK2 by PTP1B See in Reactome R-HSA-8987042 ( R-HSA-8854691 ) R-HSA-8987042 Reaction Name: IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 See in Reactome R-HSA-448744 ( R-HSA-8854691 ) R-HSA-448744 Reaction Name: IL20RA binds IL20RB See in Reactome R-HSA-8986446 ( R-HSA-8854691 ) R-HSA-8986446 Reaction Name: IL26 binds IL20RA:JAK1 See in Reactome R-HSA-8984021 ( R-HSA-8984722 ) R-HSA-8984021 Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor See in Reactome R-HSA-6809140 ( R-HSA-8984722 ) R-HSA-6809140 Reaction Name: IL35 binds IL-12RB2:IL6ST receptor See in Reactome R-HSA-8985900 ( R-HSA-8985947 ) R-HSA-8985900 Reaction Name: p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 See in Reactome R-HSA-1678841 ( R-HSA-1169408 ) R-HSA-1678841 Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 See in Reactome R-HSA-1067651 ( R-HSA-1059683 ) R-HSA-1067651 Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) See in Reactome R-HSA-8987012 ( R-HSA-8854691 ) R-HSA-8987012 Reaction Name: IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-6783524 ( R-HSA-6788467 ) R-HSA-6783524 Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130 See in Reactome R-HSA-909719 ( R-HSA-909733 ) R-HSA-909719 Reaction Name: Recruitment of STAT2 to p-IFNAR1 See in Reactome R-HSA-912527 ( R-HSA-512988; R-HSA-912526 ) R-HSA-912527 Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2 See in Reactome R-HSA-6788582 ( R-HSA-6785807 ) R-HSA-6788582 Reaction Name: STAT1,STAT3,STAT6 phosphorylation See in Reactome R-HSA-9006844 ( R-HSA-9020958 ) R-HSA-9006844 Reaction Name: IL21:IL21R:JAK1 binds IL2RG:JAK3 See in Reactome R-HSA-1112755 ( R-HSA-1059683 ) R-HSA-1112755 Reaction Name: SOCS3 binds IL6ST See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-909732 ( R-HSA-909733 ) R-HSA-909732 Reaction Name: Phosphorylation of STAT2 See in Reactome R-HSA-9009227 ( R-HSA-8854691 ) R-HSA-9009227 Reaction Name: IL20 binds to IL22RA1:JAK1:IL20RB See in Reactome R-HSA-6785165 ( R-HSA-1266695 ) R-HSA-6785165 Reaction Name: p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B See in Reactome R-HSA-913424 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913424 Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2 See in Reactome R-HSA-873921 ( R-HSA-877300 ) R-HSA-873921 Reaction Name: Binding of STAT1 to p-IFNGR1 See in Reactome R-HSA-6786058 ( R-HSA-6785807 ) R-HSA-6786058 Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1 See in Reactome R-HSA-1295540 ( R-HSA-1266695 ) R-HSA-1295540 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 See in Reactome R-HSA-8950405 ( R-HSA-8984722 ) R-HSA-8950405 Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-8952807 ( R-HSA-9020591 ) R-HSA-8952807 Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction See in Reactome R-HSA-8983063 ( R-HSA-1266695 ) R-HSA-8983063 Reaction Name: JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated See in Reactome R-HSA-8982163 ( R-HSA-8854691 ) R-HSA-8982163 Reaction Name: IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-6784189 ( R-HSA-6788467 ) R-HSA-6784189 Reaction Name: JAKs bind LIFR See in Reactome R-HSA-450027 ( R-HSA-9020558 ) R-HSA-450027 Reaction Name: Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta See in Reactome R-HSA-6784204 ( R-HSA-6788467 ) R-HSA-6784204 Reaction Name: JAKs bind OSMR See in Reactome R-HSA-8987255 ( R-HSA-8854691 ) R-HSA-8987255 Reaction Name: IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3 See in Reactome R-HSA-1295519 ( R-HSA-1266695 ) R-HSA-1295519 Reaction Name: IL7R is phosphorylated on Y499 See in Reactome R-HSA-448728 ( R-HSA-8854691 ) R-HSA-448728 Reaction Name: IL19 binds IL20RA:JAK1:IL20RB See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-8987084 ( R-HSA-8854691 ) R-HSA-8987084 Reaction Name: IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 See in Reactome R-HSA-8983003 ( R-HSA-1266695 ) R-HSA-8983003 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 See in Reactome R-HSA-449978 ( R-HSA-1266695 ) R-HSA-449978 Reaction Name: IL7 binds IL7R:JAK1 See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9011748 ( R-HSA-8985947 ) R-HSA-9011748 Reaction Name: IL9R binds JAK1 See in Reactome R-HSA-8983996 ( R-HSA-8984722 ) R-HSA-8983996 Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor See in Reactome R-HSA-8950537 ( R-HSA-9020956 ) R-HSA-8950537 Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated See in Reactome R-HSA-6786072 ( R-HSA-6785807 ) R-HSA-6786072 Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate See in Reactome R-HSA-6784323 ( R-HSA-6783783 ) R-HSA-6784323 Reaction Name: IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 See in Reactome R-HSA-8987141 ( R-HSA-8854691 ) R-HSA-8987141 Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950453 ( R-HSA-8984722 ) R-HSA-8950453 Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 See in Reactome R-HSA-873927 ( R-HSA-877300 ) R-HSA-873927 Reaction Name: Release of STAT1 dimer from active receptor unit See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-453104 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453104 Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2 See in Reactome R-HSA-449115 ( R-HSA-8983432 ) R-HSA-449115 Reaction Name: IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 See in Reactome R-HSA-8987063 ( R-HSA-8854691 ) R-HSA-8987063 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 See in Reactome R-HSA-8987043 ( R-HSA-8854691 ) R-HSA-8987043 Reaction Name: IL22RA1 binds JAK1 See in Reactome R-HSA-8983384 ( R-HSA-8983432 ) R-HSA-8983384 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome R-HSA-9006850 ( R-HSA-9020958 ) R-HSA-9006850 Reaction Name: IL21 receptor JAK phosphorylation See in Reactome R-HSA-8987150 ( R-HSA-8854691 ) R-HSA-8987150 Reaction Name: IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 See in Reactome R-HSA-8950485 ( R-HSA-9020956 ) R-HSA-8950485 Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction See in Reactome R-HSA-8983300 ( R-HSA-8983432 ) R-HSA-8983300 Reaction Name: IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 See in Reactome R-HSA-6788628 ( R-HSA-6785807 ) R-HSA-6788628 Reaction Name: p-Y-STATs dissociate See in Reactome R-HSA-873919 ( R-HSA-877300 ) R-HSA-873919 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-8983983 ( R-HSA-8984722 ) R-HSA-8983983 Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor See in Reactome R-HSA-8987096 ( R-HSA-8854691 ) R-HSA-8987096 Reaction Name: IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8950340 ( R-HSA-9020956 ) R-HSA-8950340 Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation See in Reactome R-HSA-8986995 ( R-HSA-8854691 ) R-HSA-8986995 Reaction Name: IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA See in Reactome R-HSA-8986985 ( R-HSA-8854691 ) R-HSA-8986985 Reaction Name: IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-452122 ( R-HSA-9020558 ) R-HSA-452122 Reaction Name: JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB See in Reactome R-HSA-909722 ( R-HSA-909733 ) R-HSA-909722 Reaction Name: Release of p-STAT2:p-STAT1 dimer See in Reactome R-HSA-8987033 ( R-HSA-8854691 ) R-HSA-8987033 Reaction Name: p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 See in Reactome R-HSA-8983835 ( R-HSA-8984722 ) R-HSA-8983835 Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 See in Reactome R-HSA-1067659 ( R-HSA-1059683 ) R-HSA-1067659 Reaction Name: Assembly of hexameric IL-6 receptor See in Reactome R-HSA-8983845 ( R-HSA-8984722 ) R-HSA-8983845 Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST See in Reactome R-HSA-8983309 ( R-HSA-8983432 ) R-HSA-8983309 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 See in Reactome R-HSA-448660 ( R-HSA-6788467 ) R-HSA-448660 Reaction Name: IL31:IL31RA:JAK1 binds OSMR:JAK1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-8985973 ( R-HSA-8985947 ) R-HSA-8985973 Reaction Name: IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 See in Reactome R-HSA-451942 ( R-HSA-9020558 ) R-HSA-451942 Reaction Name: Within the IL-2R complex JAK3 phosphorylates JAK1 See in Reactome R-HSA-9006870 ( R-HSA-9020958 ) R-HSA-9006870 Reaction Name: IL21 receptor STAT phosphorylation See in Reactome R-HSA-8985914 ( R-HSA-8985947 ) R-HSA-8985914 Reaction Name: IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-1112602 ( R-HSA-1059683 ) R-HSA-1112602 Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor See in Reactome R-HSA-8983299 ( R-HSA-8983432 ) R-HSA-8983299 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 See in Reactome R-HSA-8984001 ( R-HSA-8984722 ) R-HSA-8984001 Reaction Name: IL35 binds IL27RA:IL12RB2 receptor See in Reactome R-HSA-873926 ( R-HSA-877300 ) R-HSA-873926 Reaction Name: IFNG dimer binds IFNGR See in Reactome R-HSA-8987179 ( R-HSA-8854691 ) R-HSA-8987179 Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 See in Reactome R-HSA-8983378 ( R-HSA-8983432 ) R-HSA-8983378 Reaction Name: IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 See in Reactome R-HSA-453111 ( R-HSA-512988; R-HSA-912526 ) R-HSA-453111 Reaction Name: Phosphorylated SHC recruits GRB2:SOS1 See in Reactome R-HSA-6786095 ( R-HSA-6785807 ) R-HSA-6786095 Reaction Name: JAK1 phosphorylates STAT3,STAT6 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-8987230 ( R-HSA-8854691 ) R-HSA-8987230 Reaction Name: p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 See in Reactome R-HSA-8987156 ( R-HSA-8854691 ) R-HSA-8987156 Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 See in Reactome R-HSA-1295516 ( R-HSA-1266695 ) R-HSA-1295516 Reaction Name: IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits See in Reactome R-HSA-8984012 ( R-HSA-8984722 ) R-HSA-8984012 Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated See in Reactome R-HSA-6788571 ( R-HSA-6785807 ) R-HSA-6788571 Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II See in Reactome R-HSA-9674546 ( R-HSA-9674555 ) R-HSA-9674546 Reaction Name: CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1 See in Reactome
MONDO:0044339	MMP9	P14780	3.4.24.35	R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1433374 ( R-HSA-1433557 ) R-HSA-1433374 Reaction Name: Processing of SCF isoform 1 See in Reactome R-HSA-1454757 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454757 Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 See in Reactome R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1454791 ( R-HSA-1474228 ) R-HSA-1454791 Reaction Name: MMP2, MMP7, MMP9 bind CD44 See in Reactome R-HSA-1474213 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474213 Reaction Name: Collagen type III degradation by MMP1,8,9,13 See in Reactome R-HSA-1564112 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564112 Reaction Name: Collagen type VI degradation by MMP2,9,11 See in Reactome R-HSA-1564117 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564117 Reaction Name: Collagen type XIV degradation by MMP9,13 See in Reactome R-HSA-1564142 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564142 Reaction Name: Collagen type IV degradation by MMP2,3,4,9,10,12 See in Reactome R-HSA-1564164 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564164 Reaction Name: Collagen type V degradation by MMP2,9,10 See in Reactome R-HSA-1564179 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564179 Reaction Name: Collagen type XI degradation by MMP1,2,3,9 See in Reactome R-HSA-1566962 ( R-HSA-1474228 ) R-HSA-1566962 Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases See in Reactome R-HSA-1592270 ( R-HSA-1474228 ) R-HSA-1592270 Reaction Name: NID1 degradation by MMP1, 9, 12, ELANE See in Reactome R-HSA-1592436 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592436 Reaction Name: Initial activation of proMMP9 by MMPs See in Reactome R-HSA-1602454 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602454 Reaction Name: proMMP9 binds TIMP1 See in Reactome R-HSA-1604690 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604690 Reaction Name: Activation of MMP9 intermediate form by MMPs See in Reactome R-HSA-1604722 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604722 Reaction Name: Activation of proMMP9 by proteases See in Reactome R-HSA-2168923 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168923 Reaction Name: Collagen type XVIII endostatin release See in Reactome R-HSA-2168982 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168982 Reaction Name: Collagen type XVI degradation by MMP9 See in Reactome R-HSA-2213200 ( R-HSA-2022090 ) R-HSA-2213200 Reaction Name: Release of endostatin-like peptides See in Reactome R-HSA-2485148 ( R-HSA-1474228 ) R-HSA-2485148 Reaction Name: Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 See in Reactome R-HSA-3791295 ( R-HSA-1474228 ) R-HSA-3791295 Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13 See in Reactome R-HSA-3827958 ( R-HSA-1474228 ) R-HSA-3827958 Reaction Name: E-cadherin degradation by MMP9, KLK7 See in Reactome R-HSA-3928657 ( R-HSA-3928665 ) R-HSA-3928657 Reaction Name: MMP2,9 cleave EPHB See in Reactome R-HSA-6789615 ( R-HSA-6785807 ) R-HSA-6789615 Reaction Name: Expression of STAT3-upregulated extracellular proteins See in Reactome R-HSA-6798745 ( R-HSA-6798695 ) R-HSA-6798745 Reaction Name: Exocytosis of tertiary granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-8943959 ( R-HSA-1474228 ) R-HSA-8943959 Reaction Name: MMP2, MMP9 cleave SCUBE3 See in Reactome R-HSA-9624272 ( R-HSA-9009391 ) R-HSA-9624272 Reaction Name: MMPs cleave HB-EGF See in Reactome

Number of enzymes:	13
Number of disease:	29
Number of reactomes:	108
Number of reactions:	515

Search summary (Reactome ID: R-HSA-6785807)

Search results (Reactome ID: R-HSA-6785807)

MONDO:0005029

R-HSA-8984722

R-HSA-2586552

R-HSA-9020956

R-HSA-9020933

R-HSA-983231

R-HSA-9027276

R-HSA-9027277

R-HSA-5673000

R-HSA-5673001

R-HSA-982772

R-HSA-6788467

R-HSA-9705462

R-HSA-877300

R-HSA-69231

R-HSA-9006335

R-HSA-912526

R-HSA-1433557

R-HSA-9027283

R-HSA-512988

R-HSA-6785807

R-HSA-9020591

R-HSA-1059683

R-HSA-9674555

R-HSA-1170546

R-HSA-112411

R-HSA-877312

R-HSA-3214858

R-HSA-110056

R-HSA-8854691

R-HSA-9027284

R-HSA-453279

R-HSA-5683057

R-HSA-449147

R-HSA-447115

R-HSA-168256

R-HSA-451927

R-HSA-4839726

R-HSA-1280215

R-HSA-69236

R-HSA-69278

R-HSA-9006934

R-HSA-1640170

R-HSA-6783589

R-HSA-3247509

R-HSA-913531

R-HSA-5684996

R-HSA-109582

R-HSA-162582

R-HSA-112409

R-HSA-1168456

R-HSA-8983870

R-HSA-2671862

R-HSA-6786070

R-HSA-1067688

R-HSA-8950737

R-HSA-448427

R-HSA-1433418

R-HSA-8950423

R-HSA-873922

R-HSA-2586555

R-HSA-1370500

R-HSA-8987104

R-HSA-1169192

R-HSA-1168459

R-HSA-6786096

R-HSA-9012651

R-HSA-1433456

R-HSA-6785898

R-HSA-877308

R-HSA-2672302

R-HSA-873924

R-HSA-8950063

R-HSA-921155

R-HSA-9027274

R-HSA-109858

R-HSA-6783552

R-HSA-6786110