DAR - Bologna Biocomputing Group

Search results (Reactome ID: R-HSA-6782135)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005097	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0005575	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0005611	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0007959	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0008393	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0008586	POLR2B	P30876	2.7.7.6	R-HSA-6803529 R-HSA-6803529 Reactome Name: FGFR2 alternative splicing See in Reactome R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome R-HSA-203927 R-HSA-203927 Reactome Name: MicroRNA (miRNA) biogenesis See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-72203 R-HSA-72203 Reactome Name: Processing of Capped Intron-Containing Pre-mRNA See in Reactome R-HSA-73776 R-HSA-73776 Reactome Name: RNA Polymerase II Promoter Escape See in Reactome R-HSA-73779 R-HSA-73779 Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening See in Reactome R-HSA-674695 R-HSA-674695 Reactome Name: RNA Polymerase II Pre-transcription Events See in Reactome R-HSA-76042 R-HSA-76042 Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance See in Reactome R-HSA-5601884 R-HSA-5601884 Reactome Name: PIWI-interacting RNA (piRNA) biogenesis See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-72086 R-HSA-72086 Reactome Name: mRNA Capping See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-75953 R-HSA-75953 Reactome Name: RNA Polymerase II Transcription Initiation See in Reactome R-HSA-77075 R-HSA-77075 Reactome Name: RNA Pol II CTD phosphorylation and interaction with CE See in Reactome R-HSA-9670095 R-HSA-9670095 Reactome Name: Inhibition of DNA recombination at telomere See in Reactome R-HSA-72165 R-HSA-72165 Reactome Name: mRNA Splicing - Minor Pathway See in Reactome R-HSA-112382 R-HSA-112382 Reactome Name: Formation of RNA Pol II elongation complex See in Reactome R-HSA-72163 R-HSA-72163 Reactome Name: mRNA Splicing - Major Pathway See in Reactome R-HSA-6807505 R-HSA-6807505 Reactome Name: RNA polymerase II transcribes snRNA genes See in Reactome R-HSA-113418 R-HSA-113418 Reactome Name: Formation of the Early Elongation Complex See in Reactome R-HSA-5578749 R-HSA-5578749 Reactome Name: Transcriptional regulation by small RNAs See in Reactome R-HSA-75955 R-HSA-75955 Reactome Name: RNA Polymerase II Transcription Elongation See in Reactome	R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-72172 R-HSA-72172 Reactome Name: mRNA Splicing See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-157579 R-HSA-157579 Reactome Name: Telomere Maintenance See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-73886 R-HSA-73886 Reactome Name: Chromosome Maintenance See in Reactome R-HSA-211000 R-HSA-211000 Reactome Name: Gene Silencing by RNA See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of RNA DNA Repair Signal Transduction Cell Cycle Developmental Biology	R-HSA-5621002 ( R-HSA-5617472 ) R-HSA-5621002 Reaction Name: HOXB1 activates HOXB2 expression See in Reactome R-HSA-77090 ( R-HSA-72086 ) R-HSA-77090 Reaction Name: Methylation of GMP-cap by RNA Methyltransferase See in Reactome R-HSA-6803838 ( R-HSA-6803529 ) R-HSA-6803838 Reaction Name: FGFR2c-specific alternative splicing produces FGFR2c transcript See in Reactome R-HSA-109638 ( R-HSA-73779 ) R-HSA-109638 Reaction Name: Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex See in Reactome R-HSA-75866 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75866 Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP See in Reactome R-HSA-72139 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72139 Reaction Name: Formation of the active Spliceosomal C complex See in Reactome R-HSA-9012319 ( R-HSA-9018519 ) R-HSA-9012319 Reaction Name: p-TEFb phosphorylates serine 2 in RNA polymerase II CTD See in Reactome R-HSA-72095 ( R-HSA-72203 ) R-HSA-72095 Reaction Name: Internal Methylation of mRNA See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6810235 ( R-HSA-6807505 ) R-HSA-6810235 Reaction Name: RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain See in Reactome R-HSA-72107 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72107 Reaction Name: Formation of the Spliceosomal E complex See in Reactome R-HSA-113407 ( R-HSA-113418; R-HSA-75955 ) R-HSA-113407 Reaction Name: DSIF complex binds to RNA Pol II (hypophosphorylated) See in Reactome R-HSA-75095 ( R-HSA-73779 ) R-HSA-75095 Reaction Name: Binding of TFIIE to the growing preinitiation complex See in Reactome R-HSA-72124 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72124 Reaction Name: Formation of the Spliceosomal A Complex See in Reactome R-HSA-113414 ( R-HSA-674695 ) R-HSA-113414 Reaction Name: 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest See in Reactome R-HSA-75864 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75864 Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617661 ( R-HSA-5617472 ) R-HSA-5617661 Reaction Name: MAFB:JUN and EGR2 activate HOXB3 expression See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-75081 ( R-HSA-72165; R-HSA-72203 ) R-HSA-75081 Reaction Name: Formation of AT-AC B Complex See in Reactome R-HSA-203901 ( R-HSA-203927 ) R-HSA-203901 Reaction Name: Pol II mediated transcription of microRNA genes See in Reactome R-HSA-9670149 ( R-HSA-9670095 ) R-HSA-9670149 Reaction Name: TERRA transcription See in Reactome R-HSA-72130 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72130 Reaction Name: Formation of an intermediate Spliceosomal C complex See in Reactome R-HSA-6797712 ( R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome R-HSA-6781818 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781818 Reaction Name: RNA Pol II initiates transcription from damaged DNA template See in Reactome R-HSA-5617672 ( R-HSA-5617472 ) R-HSA-5617672 Reaction Name: HOXB3 gene is transcribed See in Reactome R-HSA-73946 ( R-HSA-674695 ) R-HSA-73946 Reaction Name: Abortive initiation after formation of the first phosphodiester bond See in Reactome R-HSA-77083 ( R-HSA-72086 ) R-HSA-77083 Reaction Name: Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA See in Reactome R-HSA-6810233 ( R-HSA-6807505 ) R-HSA-6810233 Reaction Name: CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter See in Reactome R-HSA-5617462 ( R-HSA-5617472 ) R-HSA-5617462 Reaction Name: HOXD1 gene is transcribed See in Reactome R-HSA-6814554 ( R-HSA-6807505 ) R-HSA-6814554 Reaction Name: Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene See in Reactome R-HSA-6803523 ( R-HSA-6803529 ) R-HSA-6803523 Reaction Name: PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA See in Reactome R-HSA-112381 ( R-HSA-112382; R-HSA-75955 ) R-HSA-112381 Reaction Name: Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex See in Reactome R-HSA-5617486 ( R-HSA-5617472 ) R-HSA-5617486 Reaction Name: HOXB2 gene is transcribed See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-9012315 ( R-HSA-9018519 ) R-HSA-9012315 Reaction Name: ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene See in Reactome R-HSA-77095 ( R-HSA-72086 ) R-HSA-77095 Reaction Name: Recognition and binding of the mRNA cap by the cap-binding complex See in Reactome R-HSA-109639 ( R-HSA-73779 ) R-HSA-109639 Reaction Name: Formation of the closed pre-initiation complex See in Reactome R-HSA-6810238 ( R-HSA-6807505 ) R-HSA-6810238 Reaction Name: RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) See in Reactome R-HSA-5578742 ( R-HSA-5578749 ) R-HSA-5578742 Reaction Name: AGO1,2:small RNA complexes interact with chromatin See in Reactome R-HSA-77085 ( R-HSA-72086 ) R-HSA-77085 Reaction Name: Dissociation of transcript with 5'-GMP from GT See in Reactome R-HSA-77073 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77073 Reaction Name: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-113430 ( R-HSA-77075 ) R-HSA-113430 Reaction Name: Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex See in Reactome R-HSA-75891 ( R-HSA-674695 ) R-HSA-75891 Reaction Name: Abortive Initiation After Second Transition See in Reactome R-HSA-6814549 ( R-HSA-6807505 ) R-HSA-6814549 Reaction Name: Pre-snRNA transcript initiation, Integrator binding, LEC binding See in Reactome R-HSA-75082 ( R-HSA-72165; R-HSA-72203 ) R-HSA-75082 Reaction Name: ATAC spliceosome mediated Lariat formation,5' splice site cleavage See in Reactome R-HSA-77068 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77068 Reaction Name: Activation of GT See in Reactome R-HSA-72160 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72160 Reaction Name: Cleavage at the 3'-Splice Site and Exon Ligation See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-77077 ( R-HSA-72086 ) R-HSA-77077 Reaction Name: Capping complex formation See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-5601926 ( R-HSA-5601884 ) R-HSA-5601926 Reaction Name: RNA polymerase II polymerizes primary piRNA transcript See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-9011971 ( R-HSA-9018519 ) R-HSA-9011971 Reaction Name: Estrogen-responsive MYB gene expression See in Reactome R-HSA-77078 ( R-HSA-72086 ) R-HSA-77078 Reaction Name: Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme See in Reactome R-HSA-5617866 ( R-HSA-5617472 ) R-HSA-5617866 Reaction Name: HOXC4 gene is transcribed See in Reactome R-HSA-5617641 ( R-HSA-5617472 ) R-HSA-5617641 Reaction Name: MAFB (KREISLER) and HOXB1:PBX1:PKNOX1 (HOXB1:PBX1:PREP1) activate HOXA3 expression See in Reactome R-HSA-9613497 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613497 Reaction Name: Unwinding DNA for the nascent transcript See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-5617492 ( R-HSA-5617472 ) R-HSA-5617492 Reaction Name: EGR2 (KROX20) activates HOXB2 expression See in Reactome R-HSA-5617484 ( R-HSA-5617472 ) R-HSA-5617484 Reaction Name: EGR2 (KROX20) activates HOXA2 expression See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-6814559 ( R-HSA-6807505 ) R-HSA-6814559 Reaction Name: Pre-snRNA is elongated and capped with 7-methylguanosine See in Reactome R-HSA-6814885 ( R-HSA-6807505 ) R-HSA-6814885 Reaction Name: CBCAP complex binds 7-methylguanosine cap of snRNA See in Reactome R-HSA-5617483 ( R-HSA-5617472 ) R-HSA-5617483 Reaction Name: HOXA2 gene is transcribed See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-77069 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77069 Reaction Name: RNA Polymerase II CTD (phosphorylated) binds to CE See in Reactome R-HSA-72127 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72127 Reaction Name: Formation of the Spliceosomal B Complex See in Reactome R-HSA-72103 ( R-HSA-72203 ) R-HSA-72103 Reaction Name: Formation of pre-mRNPs See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-113413 ( R-HSA-674695 ) R-HSA-113413 Reaction Name: TFIIS-mediated recovery of elongation from arrest See in Reactome R-HSA-75869 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75869 Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition See in Reactome R-HSA-112396 ( R-HSA-75955 ) R-HSA-112396 Reaction Name: Separation of elongating transcript from template See in Reactome R-HSA-5617445 ( R-HSA-5617472 ) R-HSA-5617445 Reaction Name: HOXD1 chromatin is activated See in Reactome R-HSA-6803836 ( R-HSA-6803529 ) R-HSA-6803836 Reaction Name: FGFR2b-specific alternative splicing produces FGFR2b transcript See in Reactome R-HSA-75079 ( R-HSA-72165; R-HSA-72203 ) R-HSA-75079 Reaction Name: Formation of AT-AC C complex See in Reactome R-HSA-113429 ( R-HSA-674695 ) R-HSA-113429 Reaction Name: Elongating transcript encounters a lesion in the template See in Reactome R-HSA-5621010 ( R-HSA-5617472 ) R-HSA-5621010 Reaction Name: HOXB1 activates HOXA2 expression See in Reactome R-HSA-113412 ( R-HSA-75955 ) R-HSA-113412 Reaction Name: Pol II elongation complex moves on the template as transcript elongates See in Reactome R-HSA-77081 ( R-HSA-72086 ) R-HSA-77081 Reaction Name: Formation of the CE:GMP intermediate complex See in Reactome R-HSA-77071 ( R-HSA-77075 ) R-HSA-77071 Reaction Name: Phosphorylation (Ser5) of RNA pol II CTD See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-112383 ( R-HSA-113418; R-HSA-75955 ) R-HSA-112383 Reaction Name: Hypophosphorylation of RNA Pol II CTD by FCP1P protein See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-75949 ( R-HSA-76042 ) R-HSA-75949 Reaction Name: RNA Polymerase II Promoter Opening: First Transition See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-75083 ( R-HSA-72165; R-HSA-72203 ) R-HSA-75083 Reaction Name: ATAC spliceosome mediated 3' splice site cleavage, exon ligation See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-5617642 ( R-HSA-5617472 ) R-HSA-5617642 Reaction Name: HOXD3 gene is transcribed See in Reactome R-HSA-6814555 ( R-HSA-6807505 ) R-HSA-6814555 Reaction Name: Integrator complex processes the 3' end of snRNA See in Reactome R-HSA-111264 ( R-HSA-73776; R-HSA-76042 ) R-HSA-111264 Reaction Name: Addition of nucleotides between position +11 and +30 See in Reactome R-HSA-5617887 ( R-HSA-5617472 ) R-HSA-5617887 Reaction Name: HOXC4 chromatin is activated See in Reactome R-HSA-112392 ( R-HSA-674695 ) R-HSA-112392 Reaction Name: Resumption of elongation after recovery from pausing See in Reactome R-HSA-6781824 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781824 Reaction Name: Active RNA Pol II complex transcribes lesion-containing DNA template See in Reactome R-HSA-6797606 ( R-HSA-6796648 ) R-HSA-6797606 Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes See in Reactome R-HSA-156661 ( R-HSA-72163; R-HSA-72203 ) R-HSA-156661 Reaction Name: Formation of Exon Junction Complex See in Reactome R-HSA-5617650 ( R-HSA-5617472 ) R-HSA-5617650 Reaction Name: HOXD3 chromatin is activated See in Reactome R-HSA-75856 ( R-HSA-674695 ) R-HSA-75856 Reaction Name: Abortive Initiation Before Second Transition See in Reactome R-HSA-113409 ( R-HSA-674695 ) R-HSA-113409 Reaction Name: Abortive termination of early transcription elongation by DSIF:NELF See in Reactome R-HSA-72143 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72143 Reaction Name: Lariat Formation and 5'-Splice Site Cleavage See in Reactome R-HSA-75080 ( R-HSA-72165; R-HSA-72203 ) R-HSA-75080 Reaction Name: Formation of AT-AC A complex See in Reactome R-HSA-75862 ( R-HSA-674695 ) R-HSA-75862 Reaction Name: Fall Back to Closed Pre-initiation Complex See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-75873 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75873 Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-112385 ( R-HSA-75955 ) R-HSA-112385 Reaction Name: Addition of nucleotides leads to transcript elongation See in Reactome R-HSA-6803527 ( R-HSA-6803529 ) R-HSA-6803527 Reaction Name: ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression See in Reactome R-HSA-5617676 ( R-HSA-5617472 ) R-HSA-5617676 Reaction Name: HOXA3 gene is transcribed See in Reactome R-HSA-75861 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75861 Reaction Name: NTP Binds Active Site of RNA Polymerase II See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-76576 ( R-HSA-73776; R-HSA-76042 ) R-HSA-76576 Reaction Name: Addition of nucleotides 10 and 11 on the growing transcript: Third Transition See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-113402 ( R-HSA-113418; R-HSA-75955 ) R-HSA-113402 Reaction Name: Formation of DSIF:NELF:early elongation complex See in Reactome R-HSA-113411 ( R-HSA-674695 ) R-HSA-113411 Reaction Name: 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing See in Reactome R-HSA-75850 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75850 Reaction Name: Addition of the third nucleotide on the nascent transcript See in Reactome R-HSA-6797616 ( R-HSA-6796648 ) R-HSA-6797616 Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-112379 ( R-HSA-112382; R-HSA-75955 ) R-HSA-112379 Reaction Name: Recruitment of elongation factors to form elongation complex See in Reactome R-HSA-112395 ( R-HSA-674695 ) R-HSA-112395 Reaction Name: Abortive termination of elongation after arrest See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-9613494 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613494 Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome
MONDO:0008955	ERCC6	Q03468	3.6.4.-	R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-427389 R-HSA-427389 Reactome Name: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome	R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome	Gene expression (Transcription) DNA Repair	R-HSA-427336 ( R-HSA-427389 ) R-HSA-427336 Reaction Name: TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9. See in Reactome R-HSA-427404 ( R-HSA-427389 ) R-HSA-427404 Reaction Name: Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-5250947 ( R-HSA-5250924 ) R-HSA-5250947 Reaction Name: B-WICH complex binds rDNA promoter See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-73739 ( R-HSA-73762 ) R-HSA-73739 Reaction Name: Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome
MONDO:0008998	ERCC6	Q03468	3.6.4.-	R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-427389 R-HSA-427389 Reactome Name: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome	R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome	Gene expression (Transcription) DNA Repair	R-HSA-427336 ( R-HSA-427389 ) R-HSA-427336 Reaction Name: TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9. See in Reactome R-HSA-427404 ( R-HSA-427389 ) R-HSA-427404 Reaction Name: Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-5250947 ( R-HSA-5250924 ) R-HSA-5250947 Reaction Name: B-WICH complex binds rDNA promoter See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-73739 ( R-HSA-73762 ) R-HSA-73739 Reaction Name: Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome
MONDO:0010150	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0010212	ERCC2	P18074	3.6.4.12	R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-73776 R-HSA-73776 Reactome Name: RNA Polymerase II Promoter Escape See in Reactome R-HSA-73779 R-HSA-73779 Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening See in Reactome R-HSA-674695 R-HSA-674695 Reactome Name: RNA Polymerase II Pre-transcription Events See in Reactome R-HSA-76042 R-HSA-76042 Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance See in Reactome R-HSA-427413 R-HSA-427413 Reactome Name: NoRC negatively regulates rRNA expression See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-72086 R-HSA-72086 Reactome Name: mRNA Capping See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-77075 R-HSA-77075 Reactome Name: RNA Pol II CTD phosphorylation and interaction with CE See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome R-HSA-73863 R-HSA-73863 Reactome Name: RNA Polymerase I Transcription Termination See in Reactome R-HSA-112382 R-HSA-112382 Reactome Name: Formation of RNA Pol II elongation complex See in Reactome R-HSA-2564830 R-HSA-2564830 Reactome Name: Cytosolic iron-sulfur cluster assembly See in Reactome R-HSA-73772 R-HSA-73772 Reactome Name: RNA Polymerase I Promoter Escape See in Reactome R-HSA-113418 R-HSA-113418 Reactome Name: Formation of the Early Elongation Complex See in Reactome R-HSA-75953 R-HSA-75953 Reactome Name: RNA Polymerase II Transcription Initiation See in Reactome R-HSA-75955 R-HSA-75955 Reactome Name: RNA Polymerase II Transcription Elongation See in Reactome	R-HSA-5250941 R-HSA-5250941 Reactome Name: Negative epigenetic regulation of rRNA expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of RNA Metabolism DNA Repair	R-HSA-109639 ( R-HSA-73779 ) R-HSA-109639 Reaction Name: Formation of the closed pre-initiation complex See in Reactome R-HSA-111264 ( R-HSA-73776; R-HSA-76042 ) R-HSA-111264 Reaction Name: Addition of nucleotides between position +11 and +30 See in Reactome R-HSA-112379 ( R-HSA-112382; R-HSA-75955 ) R-HSA-112379 Reaction Name: Recruitment of elongation factors to form elongation complex See in Reactome R-HSA-112383 ( R-HSA-113418; R-HSA-75955 ) R-HSA-112383 Reaction Name: Hypophosphorylation of RNA Pol II CTD by FCP1P protein See in Reactome R-HSA-112385 ( R-HSA-75955 ) R-HSA-112385 Reaction Name: Addition of nucleotides leads to transcript elongation See in Reactome R-HSA-113430 ( R-HSA-77075 ) R-HSA-113430 Reaction Name: Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex See in Reactome R-HSA-2564828 ( R-HSA-2564830 ) R-HSA-2564828 Reaction Name: CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins See in Reactome R-HSA-427366 ( R-HSA-427413 ) R-HSA-427366 Reaction Name: Transcription of intergenic spacer of the rRNA gene See in Reactome R-HSA-5689317 ( R-HSA-5696395 ) R-HSA-5689317 Reaction Name: Formation of the pre-incision complex in GG-NER See in Reactome R-HSA-5689861 ( R-HSA-5696395 ) R-HSA-5689861 Reaction Name: Recruitment of XPA and release of CAK See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-5690996 ( R-HSA-5696395 ) R-HSA-5690996 Reaction Name: ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA See in Reactome R-HSA-5691000 ( R-HSA-5696395 ) R-HSA-5691000 Reaction Name: TFIIH binds GG-NER site to form a verification complex See in Reactome R-HSA-5696670 ( R-HSA-5696395 ) R-HSA-5696670 Reaction Name: CHD1L is recruited to GG-NER site See in Reactome R-HSA-6781818 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781818 Reaction Name: RNA Pol II initiates transcription from damaged DNA template See in Reactome R-HSA-6781824 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781824 Reaction Name: Active RNA Pol II complex transcribes lesion-containing DNA template See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-6790454 ( R-HSA-5696395 ) R-HSA-6790454 Reaction Name: SUMOylation of XPC See in Reactome R-HSA-6790487 ( R-HSA-5696395 ) R-HSA-6790487 Reaction Name: RNF111 ubiquitinates SUMOylated XPC See in Reactome R-HSA-6797606 ( R-HSA-6796648 ) R-HSA-6797606 Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes See in Reactome R-HSA-6797616 ( R-HSA-6796648 ) R-HSA-6797616 Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes See in Reactome R-HSA-6797712 ( R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome R-HSA-73758 ( R-HSA-73762 ) R-HSA-73758 Reaction Name: Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter See in Reactome R-HSA-73769 ( R-HSA-73772 ) R-HSA-73769 Reaction Name: Loss of Rrn3 from RNA Polymerase I promoter escape complex See in Reactome R-HSA-73946 ( R-HSA-674695 ) R-HSA-73946 Reaction Name: Abortive initiation after formation of the first phosphodiester bond See in Reactome R-HSA-74986 ( R-HSA-73772 ) R-HSA-74986 Reaction Name: Elongation of pre-rRNA transcript See in Reactome R-HSA-74992 ( R-HSA-73863 ) R-HSA-74992 Reaction Name: Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box See in Reactome R-HSA-74993 ( R-HSA-73863 ) R-HSA-74993 Reaction Name: PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box See in Reactome R-HSA-74994 ( R-HSA-73863 ) R-HSA-74994 Reaction Name: Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box See in Reactome R-HSA-75850 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75850 Reaction Name: Addition of the third nucleotide on the nascent transcript See in Reactome R-HSA-75856 ( R-HSA-674695 ) R-HSA-75856 Reaction Name: Abortive Initiation Before Second Transition See in Reactome R-HSA-75861 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75861 Reaction Name: NTP Binds Active Site of RNA Polymerase II See in Reactome R-HSA-75862 ( R-HSA-674695 ) R-HSA-75862 Reaction Name: Fall Back to Closed Pre-initiation Complex See in Reactome R-HSA-75864 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75864 Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released See in Reactome R-HSA-75866 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75866 Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP See in Reactome R-HSA-75869 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75869 Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition See in Reactome R-HSA-75873 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75873 Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript See in Reactome R-HSA-75891 ( R-HSA-674695 ) R-HSA-75891 Reaction Name: Abortive Initiation After Second Transition See in Reactome R-HSA-75949 ( R-HSA-76042 ) R-HSA-75949 Reaction Name: RNA Polymerase II Promoter Opening: First Transition See in Reactome R-HSA-76576 ( R-HSA-73776; R-HSA-76042 ) R-HSA-76576 Reaction Name: Addition of nucleotides 10 and 11 on the growing transcript: Third Transition See in Reactome R-HSA-77068 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77068 Reaction Name: Activation of GT See in Reactome R-HSA-77069 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77069 Reaction Name: RNA Polymerase II CTD (phosphorylated) binds to CE See in Reactome R-HSA-77071 ( R-HSA-77075 ) R-HSA-77071 Reaction Name: Phosphorylation (Ser5) of RNA pol II CTD See in Reactome R-HSA-77073 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77073 Reaction Name: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) See in Reactome R-HSA-77077 ( R-HSA-72086 ) R-HSA-77077 Reaction Name: Capping complex formation See in Reactome R-HSA-77078 ( R-HSA-72086 ) R-HSA-77078 Reaction Name: Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme See in Reactome R-HSA-77081 ( R-HSA-72086 ) R-HSA-77081 Reaction Name: Formation of the CE:GMP intermediate complex See in Reactome R-HSA-77083 ( R-HSA-72086 ) R-HSA-77083 Reaction Name: Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA See in Reactome R-HSA-77085 ( R-HSA-72086 ) R-HSA-77085 Reaction Name: Dissociation of transcript with 5'-GMP from GT See in Reactome R-HSA-77090 ( R-HSA-72086 ) R-HSA-77090 Reaction Name: Methylation of GMP-cap by RNA Methyltransferase See in Reactome R-HSA-9613494 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613494 Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition See in Reactome R-HSA-9613497 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613497 Reaction Name: Unwinding DNA for the nascent transcript See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome
MONDO:0010215	ERCC4	Q92889	3.1.-.-	R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-6783310 R-HSA-6783310 Reactome Name: Fanconi Anemia Pathway See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome	R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome	DNA Repair	R-HSA-109955 ( R-HSA-5696395 ) R-HSA-109955 Reaction Name: Formation of ERCC1:XPF heterodimeric complex See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6785732 ( R-HSA-6783310 ) R-HSA-6785732 Reaction Name: DNA nucleases bind monoubiquitinated ID2 complex See in Reactome R-HSA-6785986 ( R-HSA-6783310 ) R-HSA-6785986 Reaction Name: DNA nucleases unhook the interstrand crosslink (ICL) See in Reactome
MONDO:0010216	ERCC5	P28715	3.1.-.-	R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome	R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome	DNA Repair	R-HSA-5689317 ( R-HSA-5696395 ) R-HSA-5689317 Reaction Name: Formation of the pre-incision complex in GG-NER See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome
MONDO:0010217	ERCC6	Q03468	3.6.4.-	R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-427389 R-HSA-427389 Reactome Name: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome	R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome	Gene expression (Transcription) DNA Repair	R-HSA-427336 ( R-HSA-427389 ) R-HSA-427336 Reaction Name: TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9. See in Reactome R-HSA-427404 ( R-HSA-427389 ) R-HSA-427404 Reaction Name: Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-5250947 ( R-HSA-5250924 ) R-HSA-5250947 Reaction Name: B-WICH complex binds rDNA promoter See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-73739 ( R-HSA-73762 ) R-HSA-73739 Reaction Name: Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome
MONDO:0010909	ERCC6	Q03468	3.6.4.-	R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-427389 R-HSA-427389 Reactome Name: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome	R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome	Gene expression (Transcription) DNA Repair	R-HSA-427336 ( R-HSA-427389 ) R-HSA-427336 Reaction Name: TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9. See in Reactome R-HSA-427404 ( R-HSA-427389 ) R-HSA-427404 Reaction Name: Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-5250947 ( R-HSA-5250924 ) R-HSA-5250947 Reaction Name: B-WICH complex binds rDNA promoter See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-73739 ( R-HSA-73762 ) R-HSA-73739 Reaction Name: Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome
MONDO:0011125	ERCC2	P18074	3.6.4.12	R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-73776 R-HSA-73776 Reactome Name: RNA Polymerase II Promoter Escape See in Reactome R-HSA-73779 R-HSA-73779 Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening See in Reactome R-HSA-674695 R-HSA-674695 Reactome Name: RNA Polymerase II Pre-transcription Events See in Reactome R-HSA-76042 R-HSA-76042 Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance See in Reactome R-HSA-427413 R-HSA-427413 Reactome Name: NoRC negatively regulates rRNA expression See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-72086 R-HSA-72086 Reactome Name: mRNA Capping See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-77075 R-HSA-77075 Reactome Name: RNA Pol II CTD phosphorylation and interaction with CE See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome R-HSA-73863 R-HSA-73863 Reactome Name: RNA Polymerase I Transcription Termination See in Reactome R-HSA-112382 R-HSA-112382 Reactome Name: Formation of RNA Pol II elongation complex See in Reactome R-HSA-2564830 R-HSA-2564830 Reactome Name: Cytosolic iron-sulfur cluster assembly See in Reactome R-HSA-73772 R-HSA-73772 Reactome Name: RNA Polymerase I Promoter Escape See in Reactome R-HSA-113418 R-HSA-113418 Reactome Name: Formation of the Early Elongation Complex See in Reactome R-HSA-75953 R-HSA-75953 Reactome Name: RNA Polymerase II Transcription Initiation See in Reactome R-HSA-75955 R-HSA-75955 Reactome Name: RNA Polymerase II Transcription Elongation See in Reactome	R-HSA-5250941 R-HSA-5250941 Reactome Name: Negative epigenetic regulation of rRNA expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of RNA Metabolism DNA Repair	R-HSA-109639 ( R-HSA-73779 ) R-HSA-109639 Reaction Name: Formation of the closed pre-initiation complex See in Reactome R-HSA-111264 ( R-HSA-73776; R-HSA-76042 ) R-HSA-111264 Reaction Name: Addition of nucleotides between position +11 and +30 See in Reactome R-HSA-112379 ( R-HSA-112382; R-HSA-75955 ) R-HSA-112379 Reaction Name: Recruitment of elongation factors to form elongation complex See in Reactome R-HSA-112383 ( R-HSA-113418; R-HSA-75955 ) R-HSA-112383 Reaction Name: Hypophosphorylation of RNA Pol II CTD by FCP1P protein See in Reactome R-HSA-112385 ( R-HSA-75955 ) R-HSA-112385 Reaction Name: Addition of nucleotides leads to transcript elongation See in Reactome R-HSA-113430 ( R-HSA-77075 ) R-HSA-113430 Reaction Name: Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex See in Reactome R-HSA-2564828 ( R-HSA-2564830 ) R-HSA-2564828 Reaction Name: CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins See in Reactome R-HSA-427366 ( R-HSA-427413 ) R-HSA-427366 Reaction Name: Transcription of intergenic spacer of the rRNA gene See in Reactome R-HSA-5689317 ( R-HSA-5696395 ) R-HSA-5689317 Reaction Name: Formation of the pre-incision complex in GG-NER See in Reactome R-HSA-5689861 ( R-HSA-5696395 ) R-HSA-5689861 Reaction Name: Recruitment of XPA and release of CAK See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-5690996 ( R-HSA-5696395 ) R-HSA-5690996 Reaction Name: ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA See in Reactome R-HSA-5691000 ( R-HSA-5696395 ) R-HSA-5691000 Reaction Name: TFIIH binds GG-NER site to form a verification complex See in Reactome R-HSA-5696670 ( R-HSA-5696395 ) R-HSA-5696670 Reaction Name: CHD1L is recruited to GG-NER site See in Reactome R-HSA-6781818 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781818 Reaction Name: RNA Pol II initiates transcription from damaged DNA template See in Reactome R-HSA-6781824 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781824 Reaction Name: Active RNA Pol II complex transcribes lesion-containing DNA template See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-6790454 ( R-HSA-5696395 ) R-HSA-6790454 Reaction Name: SUMOylation of XPC See in Reactome R-HSA-6790487 ( R-HSA-5696395 ) R-HSA-6790487 Reaction Name: RNF111 ubiquitinates SUMOylated XPC See in Reactome R-HSA-6797606 ( R-HSA-6796648 ) R-HSA-6797606 Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes See in Reactome R-HSA-6797616 ( R-HSA-6796648 ) R-HSA-6797616 Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes See in Reactome R-HSA-6797712 ( R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome R-HSA-73758 ( R-HSA-73762 ) R-HSA-73758 Reaction Name: Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter See in Reactome R-HSA-73769 ( R-HSA-73772 ) R-HSA-73769 Reaction Name: Loss of Rrn3 from RNA Polymerase I promoter escape complex See in Reactome R-HSA-73946 ( R-HSA-674695 ) R-HSA-73946 Reaction Name: Abortive initiation after formation of the first phosphodiester bond See in Reactome R-HSA-74986 ( R-HSA-73772 ) R-HSA-74986 Reaction Name: Elongation of pre-rRNA transcript See in Reactome R-HSA-74992 ( R-HSA-73863 ) R-HSA-74992 Reaction Name: Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box See in Reactome R-HSA-74993 ( R-HSA-73863 ) R-HSA-74993 Reaction Name: PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box See in Reactome R-HSA-74994 ( R-HSA-73863 ) R-HSA-74994 Reaction Name: Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box See in Reactome R-HSA-75850 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75850 Reaction Name: Addition of the third nucleotide on the nascent transcript See in Reactome R-HSA-75856 ( R-HSA-674695 ) R-HSA-75856 Reaction Name: Abortive Initiation Before Second Transition See in Reactome R-HSA-75861 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75861 Reaction Name: NTP Binds Active Site of RNA Polymerase II See in Reactome R-HSA-75862 ( R-HSA-674695 ) R-HSA-75862 Reaction Name: Fall Back to Closed Pre-initiation Complex See in Reactome R-HSA-75864 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75864 Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released See in Reactome R-HSA-75866 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75866 Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP See in Reactome R-HSA-75869 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75869 Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition See in Reactome R-HSA-75873 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75873 Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript See in Reactome R-HSA-75891 ( R-HSA-674695 ) R-HSA-75891 Reaction Name: Abortive Initiation After Second Transition See in Reactome R-HSA-75949 ( R-HSA-76042 ) R-HSA-75949 Reaction Name: RNA Polymerase II Promoter Opening: First Transition See in Reactome R-HSA-76576 ( R-HSA-73776; R-HSA-76042 ) R-HSA-76576 Reaction Name: Addition of nucleotides 10 and 11 on the growing transcript: Third Transition See in Reactome R-HSA-77068 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77068 Reaction Name: Activation of GT See in Reactome R-HSA-77069 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77069 Reaction Name: RNA Polymerase II CTD (phosphorylated) binds to CE See in Reactome R-HSA-77071 ( R-HSA-77075 ) R-HSA-77071 Reaction Name: Phosphorylation (Ser5) of RNA pol II CTD See in Reactome R-HSA-77073 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77073 Reaction Name: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) See in Reactome R-HSA-77077 ( R-HSA-72086 ) R-HSA-77077 Reaction Name: Capping complex formation See in Reactome R-HSA-77078 ( R-HSA-72086 ) R-HSA-77078 Reaction Name: Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme See in Reactome R-HSA-77081 ( R-HSA-72086 ) R-HSA-77081 Reaction Name: Formation of the CE:GMP intermediate complex See in Reactome R-HSA-77083 ( R-HSA-72086 ) R-HSA-77083 Reaction Name: Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA See in Reactome R-HSA-77085 ( R-HSA-72086 ) R-HSA-77085 Reaction Name: Dissociation of transcript with 5'-GMP from GT See in Reactome R-HSA-77090 ( R-HSA-72086 ) R-HSA-77090 Reaction Name: Methylation of GMP-cap by RNA Methyltransferase See in Reactome R-HSA-9613494 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613494 Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition See in Reactome R-HSA-9613497 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613497 Reaction Name: Unwinding DNA for the nascent transcript See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome
MONDO:0012531	ERCC3	P19447	3.6.4.12	R-HSA-75955 R-HSA-75955 Reactome Name: RNA Polymerase II Transcription Elongation See in Reactome R-HSA-112382 R-HSA-112382 Reactome Name: Formation of RNA Pol II elongation complex See in Reactome R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-427413 R-HSA-427413 Reactome Name: NoRC negatively regulates rRNA expression See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-75953 R-HSA-75953 Reactome Name: RNA Polymerase II Transcription Initiation See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome R-HSA-73863 R-HSA-73863 Reactome Name: RNA Polymerase I Transcription Termination See in Reactome R-HSA-73776 R-HSA-73776 Reactome Name: RNA Polymerase II Promoter Escape See in Reactome R-HSA-73779 R-HSA-73779 Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening See in Reactome R-HSA-76042 R-HSA-76042 Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance See in Reactome R-HSA-77075 R-HSA-77075 Reactome Name: RNA Pol II CTD phosphorylation and interaction with CE See in Reactome R-HSA-73772 R-HSA-73772 Reactome Name: RNA Polymerase I Promoter Escape See in Reactome R-HSA-72086 R-HSA-72086 Reactome Name: mRNA Capping See in Reactome R-HSA-113418 R-HSA-113418 Reactome Name: Formation of the Early Elongation Complex See in Reactome R-HSA-674695 R-HSA-674695 Reactome Name: RNA Polymerase II Pre-transcription Events See in Reactome	R-HSA-5250941 R-HSA-5250941 Reactome Name: Negative epigenetic regulation of rRNA expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of RNA DNA Repair	R-HSA-109639 ( R-HSA-73779 ) R-HSA-109639 Reaction Name: Formation of the closed pre-initiation complex See in Reactome R-HSA-111264 ( R-HSA-73776; R-HSA-76042 ) R-HSA-111264 Reaction Name: Addition of nucleotides between position +11 and +30 See in Reactome R-HSA-112379 ( R-HSA-112382; R-HSA-75955 ) R-HSA-112379 Reaction Name: Recruitment of elongation factors to form elongation complex See in Reactome R-HSA-112383 ( R-HSA-113418; R-HSA-75955 ) R-HSA-112383 Reaction Name: Hypophosphorylation of RNA Pol II CTD by FCP1P protein See in Reactome R-HSA-112385 ( R-HSA-75955 ) R-HSA-112385 Reaction Name: Addition of nucleotides leads to transcript elongation See in Reactome R-HSA-113430 ( R-HSA-77075 ) R-HSA-113430 Reaction Name: Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex See in Reactome R-HSA-427366 ( R-HSA-427413 ) R-HSA-427366 Reaction Name: Transcription of intergenic spacer of the rRNA gene See in Reactome R-HSA-5689317 ( R-HSA-5696395 ) R-HSA-5689317 Reaction Name: Formation of the pre-incision complex in GG-NER See in Reactome R-HSA-5689861 ( R-HSA-5696395 ) R-HSA-5689861 Reaction Name: Recruitment of XPA and release of CAK See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-5690996 ( R-HSA-5696395 ) R-HSA-5690996 Reaction Name: ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA See in Reactome R-HSA-5691000 ( R-HSA-5696395 ) R-HSA-5691000 Reaction Name: TFIIH binds GG-NER site to form a verification complex See in Reactome R-HSA-5696670 ( R-HSA-5696395 ) R-HSA-5696670 Reaction Name: CHD1L is recruited to GG-NER site See in Reactome R-HSA-6781818 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781818 Reaction Name: RNA Pol II initiates transcription from damaged DNA template See in Reactome R-HSA-6781824 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781824 Reaction Name: Active RNA Pol II complex transcribes lesion-containing DNA template See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-6790454 ( R-HSA-5696395 ) R-HSA-6790454 Reaction Name: SUMOylation of XPC See in Reactome R-HSA-6790487 ( R-HSA-5696395 ) R-HSA-6790487 Reaction Name: RNF111 ubiquitinates SUMOylated XPC See in Reactome R-HSA-6797606 ( R-HSA-6796648 ) R-HSA-6797606 Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes See in Reactome R-HSA-6797616 ( R-HSA-6796648 ) R-HSA-6797616 Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes See in Reactome R-HSA-6797712 ( R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome R-HSA-73758 ( R-HSA-73762 ) R-HSA-73758 Reaction Name: Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter See in Reactome R-HSA-73769 ( R-HSA-73772 ) R-HSA-73769 Reaction Name: Loss of Rrn3 from RNA Polymerase I promoter escape complex See in Reactome R-HSA-73946 ( R-HSA-674695 ) R-HSA-73946 Reaction Name: Abortive initiation after formation of the first phosphodiester bond See in Reactome R-HSA-74986 ( R-HSA-73772 ) R-HSA-74986 Reaction Name: Elongation of pre-rRNA transcript See in Reactome R-HSA-74992 ( R-HSA-73863 ) R-HSA-74992 Reaction Name: Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box See in Reactome R-HSA-74993 ( R-HSA-73863 ) R-HSA-74993 Reaction Name: PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box See in Reactome R-HSA-74994 ( R-HSA-73863 ) R-HSA-74994 Reaction Name: Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box See in Reactome R-HSA-75850 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75850 Reaction Name: Addition of the third nucleotide on the nascent transcript See in Reactome R-HSA-75856 ( R-HSA-674695 ) R-HSA-75856 Reaction Name: Abortive Initiation Before Second Transition See in Reactome R-HSA-75861 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75861 Reaction Name: NTP Binds Active Site of RNA Polymerase II See in Reactome R-HSA-75862 ( R-HSA-674695 ) R-HSA-75862 Reaction Name: Fall Back to Closed Pre-initiation Complex See in Reactome R-HSA-75864 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75864 Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released See in Reactome R-HSA-75866 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75866 Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP See in Reactome R-HSA-75869 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75869 Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition See in Reactome R-HSA-75873 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75873 Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript See in Reactome R-HSA-75891 ( R-HSA-674695 ) R-HSA-75891 Reaction Name: Abortive Initiation After Second Transition See in Reactome R-HSA-75949 ( R-HSA-76042 ) R-HSA-75949 Reaction Name: RNA Polymerase II Promoter Opening: First Transition See in Reactome R-HSA-76576 ( R-HSA-73776; R-HSA-76042 ) R-HSA-76576 Reaction Name: Addition of nucleotides 10 and 11 on the growing transcript: Third Transition See in Reactome R-HSA-77068 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77068 Reaction Name: Activation of GT See in Reactome R-HSA-77069 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77069 Reaction Name: RNA Polymerase II CTD (phosphorylated) binds to CE See in Reactome R-HSA-77071 ( R-HSA-77075 ) R-HSA-77071 Reaction Name: Phosphorylation (Ser5) of RNA pol II CTD See in Reactome R-HSA-77073 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77073 Reaction Name: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) See in Reactome R-HSA-77077 ( R-HSA-72086 ) R-HSA-77077 Reaction Name: Capping complex formation See in Reactome R-HSA-77078 ( R-HSA-72086 ) R-HSA-77078 Reaction Name: Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme See in Reactome R-HSA-77081 ( R-HSA-72086 ) R-HSA-77081 Reaction Name: Formation of the CE:GMP intermediate complex See in Reactome R-HSA-77083 ( R-HSA-72086 ) R-HSA-77083 Reaction Name: Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA See in Reactome R-HSA-77085 ( R-HSA-72086 ) R-HSA-77085 Reaction Name: Dissociation of transcript with 5'-GMP from GT See in Reactome R-HSA-77090 ( R-HSA-72086 ) R-HSA-77090 Reaction Name: Methylation of GMP-cap by RNA Methyltransferase See in Reactome R-HSA-9613494 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613494 Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition See in Reactome R-HSA-9613497 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613497 Reaction Name: Unwinding DNA for the nascent transcript See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome
MONDO:0012553	ERCC2	P18074	3.6.4.12	R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-73776 R-HSA-73776 Reactome Name: RNA Polymerase II Promoter Escape See in Reactome R-HSA-73779 R-HSA-73779 Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening See in Reactome R-HSA-674695 R-HSA-674695 Reactome Name: RNA Polymerase II Pre-transcription Events See in Reactome R-HSA-76042 R-HSA-76042 Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance See in Reactome R-HSA-427413 R-HSA-427413 Reactome Name: NoRC negatively regulates rRNA expression See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-72086 R-HSA-72086 Reactome Name: mRNA Capping See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-77075 R-HSA-77075 Reactome Name: RNA Pol II CTD phosphorylation and interaction with CE See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome R-HSA-73863 R-HSA-73863 Reactome Name: RNA Polymerase I Transcription Termination See in Reactome R-HSA-112382 R-HSA-112382 Reactome Name: Formation of RNA Pol II elongation complex See in Reactome R-HSA-2564830 R-HSA-2564830 Reactome Name: Cytosolic iron-sulfur cluster assembly See in Reactome R-HSA-73772 R-HSA-73772 Reactome Name: RNA Polymerase I Promoter Escape See in Reactome R-HSA-113418 R-HSA-113418 Reactome Name: Formation of the Early Elongation Complex See in Reactome R-HSA-75953 R-HSA-75953 Reactome Name: RNA Polymerase II Transcription Initiation See in Reactome R-HSA-75955 R-HSA-75955 Reactome Name: RNA Polymerase II Transcription Elongation See in Reactome	R-HSA-5250941 R-HSA-5250941 Reactome Name: Negative epigenetic regulation of rRNA expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of RNA Metabolism DNA Repair	R-HSA-109639 ( R-HSA-73779 ) R-HSA-109639 Reaction Name: Formation of the closed pre-initiation complex See in Reactome R-HSA-111264 ( R-HSA-73776; R-HSA-76042 ) R-HSA-111264 Reaction Name: Addition of nucleotides between position +11 and +30 See in Reactome R-HSA-112379 ( R-HSA-112382; R-HSA-75955 ) R-HSA-112379 Reaction Name: Recruitment of elongation factors to form elongation complex See in Reactome R-HSA-112383 ( R-HSA-113418; R-HSA-75955 ) R-HSA-112383 Reaction Name: Hypophosphorylation of RNA Pol II CTD by FCP1P protein See in Reactome R-HSA-112385 ( R-HSA-75955 ) R-HSA-112385 Reaction Name: Addition of nucleotides leads to transcript elongation See in Reactome R-HSA-113430 ( R-HSA-77075 ) R-HSA-113430 Reaction Name: Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex See in Reactome R-HSA-2564828 ( R-HSA-2564830 ) R-HSA-2564828 Reaction Name: CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins See in Reactome R-HSA-427366 ( R-HSA-427413 ) R-HSA-427366 Reaction Name: Transcription of intergenic spacer of the rRNA gene See in Reactome R-HSA-5689317 ( R-HSA-5696395 ) R-HSA-5689317 Reaction Name: Formation of the pre-incision complex in GG-NER See in Reactome R-HSA-5689861 ( R-HSA-5696395 ) R-HSA-5689861 Reaction Name: Recruitment of XPA and release of CAK See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-5690996 ( R-HSA-5696395 ) R-HSA-5690996 Reaction Name: ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA See in Reactome R-HSA-5691000 ( R-HSA-5696395 ) R-HSA-5691000 Reaction Name: TFIIH binds GG-NER site to form a verification complex See in Reactome R-HSA-5696670 ( R-HSA-5696395 ) R-HSA-5696670 Reaction Name: CHD1L is recruited to GG-NER site See in Reactome R-HSA-6781818 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781818 Reaction Name: RNA Pol II initiates transcription from damaged DNA template See in Reactome R-HSA-6781824 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781824 Reaction Name: Active RNA Pol II complex transcribes lesion-containing DNA template See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-6790454 ( R-HSA-5696395 ) R-HSA-6790454 Reaction Name: SUMOylation of XPC See in Reactome R-HSA-6790487 ( R-HSA-5696395 ) R-HSA-6790487 Reaction Name: RNF111 ubiquitinates SUMOylated XPC See in Reactome R-HSA-6797606 ( R-HSA-6796648 ) R-HSA-6797606 Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes See in Reactome R-HSA-6797616 ( R-HSA-6796648 ) R-HSA-6797616 Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes See in Reactome R-HSA-6797712 ( R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome R-HSA-73758 ( R-HSA-73762 ) R-HSA-73758 Reaction Name: Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter See in Reactome R-HSA-73769 ( R-HSA-73772 ) R-HSA-73769 Reaction Name: Loss of Rrn3 from RNA Polymerase I promoter escape complex See in Reactome R-HSA-73946 ( R-HSA-674695 ) R-HSA-73946 Reaction Name: Abortive initiation after formation of the first phosphodiester bond See in Reactome R-HSA-74986 ( R-HSA-73772 ) R-HSA-74986 Reaction Name: Elongation of pre-rRNA transcript See in Reactome R-HSA-74992 ( R-HSA-73863 ) R-HSA-74992 Reaction Name: Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box See in Reactome R-HSA-74993 ( R-HSA-73863 ) R-HSA-74993 Reaction Name: PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box See in Reactome R-HSA-74994 ( R-HSA-73863 ) R-HSA-74994 Reaction Name: Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box See in Reactome R-HSA-75850 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75850 Reaction Name: Addition of the third nucleotide on the nascent transcript See in Reactome R-HSA-75856 ( R-HSA-674695 ) R-HSA-75856 Reaction Name: Abortive Initiation Before Second Transition See in Reactome R-HSA-75861 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75861 Reaction Name: NTP Binds Active Site of RNA Polymerase II See in Reactome R-HSA-75862 ( R-HSA-674695 ) R-HSA-75862 Reaction Name: Fall Back to Closed Pre-initiation Complex See in Reactome R-HSA-75864 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75864 Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released See in Reactome R-HSA-75866 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75866 Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP See in Reactome R-HSA-75869 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75869 Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition See in Reactome R-HSA-75873 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75873 Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript See in Reactome R-HSA-75891 ( R-HSA-674695 ) R-HSA-75891 Reaction Name: Abortive Initiation After Second Transition See in Reactome R-HSA-75949 ( R-HSA-76042 ) R-HSA-75949 Reaction Name: RNA Polymerase II Promoter Opening: First Transition See in Reactome R-HSA-76576 ( R-HSA-73776; R-HSA-76042 ) R-HSA-76576 Reaction Name: Addition of nucleotides 10 and 11 on the growing transcript: Third Transition See in Reactome R-HSA-77068 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77068 Reaction Name: Activation of GT See in Reactome R-HSA-77069 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77069 Reaction Name: RNA Polymerase II CTD (phosphorylated) binds to CE See in Reactome R-HSA-77071 ( R-HSA-77075 ) R-HSA-77071 Reaction Name: Phosphorylation (Ser5) of RNA pol II CTD See in Reactome R-HSA-77073 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77073 Reaction Name: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) See in Reactome R-HSA-77077 ( R-HSA-72086 ) R-HSA-77077 Reaction Name: Capping complex formation See in Reactome R-HSA-77078 ( R-HSA-72086 ) R-HSA-77078 Reaction Name: Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme See in Reactome R-HSA-77081 ( R-HSA-72086 ) R-HSA-77081 Reaction Name: Formation of the CE:GMP intermediate complex See in Reactome R-HSA-77083 ( R-HSA-72086 ) R-HSA-77083 Reaction Name: Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA See in Reactome R-HSA-77085 ( R-HSA-72086 ) R-HSA-77085 Reaction Name: Dissociation of transcript with 5'-GMP from GT See in Reactome R-HSA-77090 ( R-HSA-72086 ) R-HSA-77090 Reaction Name: Methylation of GMP-cap by RNA Methyltransferase See in Reactome R-HSA-9613494 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613494 Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition See in Reactome R-HSA-9613497 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613497 Reaction Name: Unwinding DNA for the nascent transcript See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome
MONDO:0012590	ERCC4	Q92889	3.1.-.-	R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-6783310 R-HSA-6783310 Reactome Name: Fanconi Anemia Pathway See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome	R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome	DNA Repair	R-HSA-109955 ( R-HSA-5696395 ) R-HSA-109955 Reaction Name: Formation of ERCC1:XPF heterodimeric complex See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6785732 ( R-HSA-6783310 ) R-HSA-6785732 Reaction Name: DNA nucleases bind monoubiquitinated ID2 complex See in Reactome R-HSA-6785986 ( R-HSA-6783310 ) R-HSA-6785986 Reaction Name: DNA nucleases unhook the interstrand crosslink (ICL) See in Reactome
MONDO:0012953	POLD1	P28340	3.1.11.- 2.7.7.7	R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5358606 R-HSA-5358606 Reactome Name: Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) See in Reactome R-HSA-5696397 R-HSA-5696397 Reactome Name: Gap-filling DNA repair synthesis and ligation in GG-NER See in Reactome R-HSA-69091 R-HSA-69091 Reactome Name: Polymerase switching See in Reactome R-HSA-110314 R-HSA-110314 Reactome Name: Recognition of DNA damage by PCNA-containing replication complex See in Reactome R-HSA-174414 R-HSA-174414 Reactome Name: Processive synthesis on the C-strand of the telomere See in Reactome R-HSA-174417 R-HSA-174417 Reactome Name: Telomere C-strand (Lagging Strand) Synthesis See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-174411 R-HSA-174411 Reactome Name: Polymerase switching on the C-strand of the telomere See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-174437 R-HSA-174437 Reactome Name: Removal of the Flap Intermediate from the C-strand See in Reactome R-HSA-5358565 R-HSA-5358565 Reactome Name: Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) See in Reactome R-HSA-5651801 R-HSA-5651801 Reactome Name: PCNA-Dependent Long Patch Base Excision Repair See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-2564830 R-HSA-2564830 Reactome Name: Cytosolic iron-sulfur cluster assembly See in Reactome R-HSA-69166 R-HSA-69166 Reactome Name: Removal of the Flap Intermediate See in Reactome R-HSA-5656169 R-HSA-5656169 Reactome Name: Termination of translesion DNA synthesis See in Reactome R-HSA-69183 R-HSA-69183 Reactome Name: Processive synthesis on the lagging strand See in Reactome	R-HSA-69109 R-HSA-69109 Reactome Name: Leading Strand Synthesis See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-69190 R-HSA-69190 Reactome Name: DNA strand elongation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-73886 R-HSA-73886 Reactome Name: Chromosome Maintenance See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-110373 R-HSA-110373 Reactome Name: Resolution of AP sites via the multiple-nucleotide patch replacement pathway See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-157579 R-HSA-157579 Reactome Name: Telomere Maintenance See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-5358508 R-HSA-5358508 Reactome Name: Mismatch Repair See in Reactome R-HSA-180786 R-HSA-180786 Reactome Name: Extension of Telomeres See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-69186 R-HSA-69186 Reactome Name: Lagging Strand Synthesis See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	Cell Cycle DNA Replication DNA Repair Metabolism	R-HSA-110363 ( R-HSA-5651801 ) R-HSA-110363 Reaction Name: FEN1 bound to PCNA and APEX1 cleaves flap ssDNA See in Reactome R-HSA-110364 ( R-HSA-5651801 ) R-HSA-110364 Reaction Name: PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 See in Reactome R-HSA-110368 ( R-HSA-5651801 ) R-HSA-110368 Reaction Name: POLD,POLE-mediated DNA strand displacement synthesis See in Reactome R-HSA-110371 ( R-HSA-5651801 ) R-HSA-110371 Reaction Name: LIG1 binds APEX1 and PCNA at SSB See in Reactome R-HSA-174438 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174438 Reaction Name: Formation of the Flap Intermediate on the C-strand See in Reactome R-HSA-174441 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174441 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand See in Reactome R-HSA-174444 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174444 Reaction Name: Formation of C-strand Okazaki fragments See in Reactome R-HSA-174445 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174445 Reaction Name: RPA binds to the Flap on the C-strand See in Reactome R-HSA-174446 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174446 Reaction Name: Removal of remaining Flap from the C-strand See in Reactome R-HSA-174448 ( R-HSA-174411; R-HSA-174417 ) R-HSA-174448 Reaction Name: Formation of Processive Complex on the C-strand of the telomere See in Reactome R-HSA-174451 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174451 Reaction Name: Recruitment of DNA2 endonuclease to the C strand See in Reactome R-HSA-174456 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174456 Reaction Name: Joining of adjacent Okazaki fragments of the C-strand See in Reactome R-HSA-176702 ( R-HSA-174417 ) R-HSA-176702 Reaction Name: Disassociation of Processive Complex and Completed Telomere End See in Reactome R-HSA-2564828 ( R-HSA-2564830 ) R-HSA-2564828 Reaction Name: CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins See in Reactome R-HSA-5358579 ( R-HSA-5358565; R-HSA-5358606 ) R-HSA-5358579 Reaction Name: DNA polymerase delta polymerizes DNA across single stranded gap See in Reactome R-HSA-5651805 ( R-HSA-5651801 ) R-HSA-5651805 Reaction Name: LIG1 bound to APEX1 and PCNA ligates SSB See in Reactome R-HSA-5651809 ( R-HSA-5651801 ) R-HSA-5651809 Reaction Name: LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA See in Reactome R-HSA-5651992 ( R-HSA-110314 ) R-HSA-5651992 Reaction Name: PCNA-containing replication complex binds damaged dsDNA See in Reactome R-HSA-5652005 ( R-HSA-110314 ) R-HSA-5652005 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA See in Reactome R-HSA-5652009 ( R-HSA-110314 ) R-HSA-5652009 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA See in Reactome R-HSA-5653838 ( R-HSA-5656169 ) R-HSA-5653838 Reaction Name: POLD,POLE binds deISGylated PCNA after TLS See in Reactome R-HSA-5653840 ( R-HSA-5656169 ) R-HSA-5653840 Reaction Name: POLD,POLE complete replication of damaged DNA after TLS See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690997 ( R-HSA-5696397 ) R-HSA-5690997 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in GG-NER See in Reactome R-HSA-5691001 ( R-HSA-5696397 ) R-HSA-5691001 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-6782208 ( R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-69074 ( R-HSA-69091 ) R-HSA-69074 Reaction Name: Formation of Processive Complex See in Reactome R-HSA-69116 ( R-HSA-69183 ) R-HSA-69116 Reaction Name: Formation of Okazaki fragments See in Reactome R-HSA-69127 ( R-HSA-69183 ) R-HSA-69127 Reaction Name: Formation of the Flap Intermediate See in Reactome R-HSA-69140 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69140 Reaction Name: RPA binds to the Flap See in Reactome R-HSA-69142 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69142 Reaction Name: Recruitment of Dna2 endonuclease See in Reactome R-HSA-69144 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69144 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 See in Reactome R-HSA-69152 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69152 Reaction Name: Removal of remaining Flap See in Reactome
MONDO:0013364	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0013409	ERCC6	Q03468	3.6.4.-	R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-427389 R-HSA-427389 Reactome Name: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome	R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome	Gene expression (Transcription) DNA Repair	R-HSA-427336 ( R-HSA-427389 ) R-HSA-427336 Reaction Name: TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9. See in Reactome R-HSA-427404 ( R-HSA-427389 ) R-HSA-427404 Reaction Name: Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-5250947 ( R-HSA-5250924 ) R-HSA-5250947 Reaction Name: B-WICH complex binds rDNA promoter See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-73739 ( R-HSA-73762 ) R-HSA-73739 Reaction Name: Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome
MONDO:0013873	POLE	Q07864	3.1.11.- 2.7.7.7	R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-5696397 R-HSA-5696397 Reactome Name: Gap-filling DNA repair synthesis and ligation in GG-NER See in Reactome R-HSA-68952 R-HSA-68952 Reactome Name: DNA replication initiation See in Reactome R-HSA-110314 R-HSA-110314 Reactome Name: Recognition of DNA damage by PCNA-containing replication complex See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5651801 R-HSA-5651801 Reactome Name: PCNA-Dependent Long Patch Base Excision Repair See in Reactome R-HSA-5656169 R-HSA-5656169 Reactome Name: Termination of translesion DNA synthesis See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-110373 R-HSA-110373 Reactome Name: Resolution of AP sites via the multiple-nucleotide patch replacement pathway See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	DNA Repair DNA Replication Cell Cycle	R-HSA-110363 ( R-HSA-5651801 ) R-HSA-110363 Reaction Name: FEN1 bound to PCNA and APEX1 cleaves flap ssDNA See in Reactome R-HSA-110364 ( R-HSA-5651801 ) R-HSA-110364 Reaction Name: PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 See in Reactome R-HSA-110368 ( R-HSA-5651801 ) R-HSA-110368 Reaction Name: POLD,POLE-mediated DNA strand displacement synthesis See in Reactome R-HSA-110371 ( R-HSA-5651801 ) R-HSA-110371 Reaction Name: LIG1 binds APEX1 and PCNA at SSB See in Reactome R-HSA-5651805 ( R-HSA-5651801 ) R-HSA-5651805 Reaction Name: LIG1 bound to APEX1 and PCNA ligates SSB See in Reactome R-HSA-5651809 ( R-HSA-5651801 ) R-HSA-5651809 Reaction Name: LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA See in Reactome R-HSA-5651992 ( R-HSA-110314 ) R-HSA-5651992 Reaction Name: PCNA-containing replication complex binds damaged dsDNA See in Reactome R-HSA-5652005 ( R-HSA-110314 ) R-HSA-5652005 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA See in Reactome R-HSA-5652009 ( R-HSA-110314 ) R-HSA-5652009 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA See in Reactome R-HSA-5653838 ( R-HSA-5656169 ) R-HSA-5653838 Reaction Name: POLD,POLE binds deISGylated PCNA after TLS See in Reactome R-HSA-5653840 ( R-HSA-5656169 ) R-HSA-5653840 Reaction Name: POLD,POLE complete replication of damaged DNA after TLS See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690997 ( R-HSA-5696397 ) R-HSA-5690997 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in GG-NER See in Reactome R-HSA-5691001 ( R-HSA-5696397 ) R-HSA-5691001 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-68913 ( R-HSA-68952 ) R-HSA-68913 Reaction Name: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68960 ( R-HSA-68962 ) R-HSA-68960 Reaction Name: DNA polymerase epsilon binds at the origin See in Reactome
MONDO:0014038	POLE	Q07864	3.1.11.- 2.7.7.7	R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-5696397 R-HSA-5696397 Reactome Name: Gap-filling DNA repair synthesis and ligation in GG-NER See in Reactome R-HSA-68952 R-HSA-68952 Reactome Name: DNA replication initiation See in Reactome R-HSA-110314 R-HSA-110314 Reactome Name: Recognition of DNA damage by PCNA-containing replication complex See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5651801 R-HSA-5651801 Reactome Name: PCNA-Dependent Long Patch Base Excision Repair See in Reactome R-HSA-5656169 R-HSA-5656169 Reactome Name: Termination of translesion DNA synthesis See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-110373 R-HSA-110373 Reactome Name: Resolution of AP sites via the multiple-nucleotide patch replacement pathway See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	DNA Repair DNA Replication Cell Cycle	R-HSA-110363 ( R-HSA-5651801 ) R-HSA-110363 Reaction Name: FEN1 bound to PCNA and APEX1 cleaves flap ssDNA See in Reactome R-HSA-110364 ( R-HSA-5651801 ) R-HSA-110364 Reaction Name: PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 See in Reactome R-HSA-110368 ( R-HSA-5651801 ) R-HSA-110368 Reaction Name: POLD,POLE-mediated DNA strand displacement synthesis See in Reactome R-HSA-110371 ( R-HSA-5651801 ) R-HSA-110371 Reaction Name: LIG1 binds APEX1 and PCNA at SSB See in Reactome R-HSA-5651805 ( R-HSA-5651801 ) R-HSA-5651805 Reaction Name: LIG1 bound to APEX1 and PCNA ligates SSB See in Reactome R-HSA-5651809 ( R-HSA-5651801 ) R-HSA-5651809 Reaction Name: LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA See in Reactome R-HSA-5651992 ( R-HSA-110314 ) R-HSA-5651992 Reaction Name: PCNA-containing replication complex binds damaged dsDNA See in Reactome R-HSA-5652005 ( R-HSA-110314 ) R-HSA-5652005 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA See in Reactome R-HSA-5652009 ( R-HSA-110314 ) R-HSA-5652009 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA See in Reactome R-HSA-5653838 ( R-HSA-5656169 ) R-HSA-5653838 Reaction Name: POLD,POLE binds deISGylated PCNA after TLS See in Reactome R-HSA-5653840 ( R-HSA-5656169 ) R-HSA-5653840 Reaction Name: POLD,POLE complete replication of damaged DNA after TLS See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690997 ( R-HSA-5696397 ) R-HSA-5690997 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in GG-NER See in Reactome R-HSA-5691001 ( R-HSA-5696397 ) R-HSA-5691001 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-68913 ( R-HSA-68952 ) R-HSA-68913 Reaction Name: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68960 ( R-HSA-68962 ) R-HSA-68960 Reaction Name: DNA polymerase epsilon binds at the origin See in Reactome
MONDO:0014058	POLE	Q07864	3.1.11.- 2.7.7.7	R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-5696397 R-HSA-5696397 Reactome Name: Gap-filling DNA repair synthesis and ligation in GG-NER See in Reactome R-HSA-68952 R-HSA-68952 Reactome Name: DNA replication initiation See in Reactome R-HSA-110314 R-HSA-110314 Reactome Name: Recognition of DNA damage by PCNA-containing replication complex See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5651801 R-HSA-5651801 Reactome Name: PCNA-Dependent Long Patch Base Excision Repair See in Reactome R-HSA-5656169 R-HSA-5656169 Reactome Name: Termination of translesion DNA synthesis See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-110373 R-HSA-110373 Reactome Name: Resolution of AP sites via the multiple-nucleotide patch replacement pathway See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	DNA Repair DNA Replication Cell Cycle	R-HSA-110363 ( R-HSA-5651801 ) R-HSA-110363 Reaction Name: FEN1 bound to PCNA and APEX1 cleaves flap ssDNA See in Reactome R-HSA-110364 ( R-HSA-5651801 ) R-HSA-110364 Reaction Name: PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 See in Reactome R-HSA-110368 ( R-HSA-5651801 ) R-HSA-110368 Reaction Name: POLD,POLE-mediated DNA strand displacement synthesis See in Reactome R-HSA-110371 ( R-HSA-5651801 ) R-HSA-110371 Reaction Name: LIG1 binds APEX1 and PCNA at SSB See in Reactome R-HSA-5651805 ( R-HSA-5651801 ) R-HSA-5651805 Reaction Name: LIG1 bound to APEX1 and PCNA ligates SSB See in Reactome R-HSA-5651809 ( R-HSA-5651801 ) R-HSA-5651809 Reaction Name: LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA See in Reactome R-HSA-5651992 ( R-HSA-110314 ) R-HSA-5651992 Reaction Name: PCNA-containing replication complex binds damaged dsDNA See in Reactome R-HSA-5652005 ( R-HSA-110314 ) R-HSA-5652005 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA See in Reactome R-HSA-5652009 ( R-HSA-110314 ) R-HSA-5652009 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA See in Reactome R-HSA-5653838 ( R-HSA-5656169 ) R-HSA-5653838 Reaction Name: POLD,POLE binds deISGylated PCNA after TLS See in Reactome R-HSA-5653840 ( R-HSA-5656169 ) R-HSA-5653840 Reaction Name: POLD,POLE complete replication of damaged DNA after TLS See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690997 ( R-HSA-5696397 ) R-HSA-5690997 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in GG-NER See in Reactome R-HSA-5691001 ( R-HSA-5696397 ) R-HSA-5691001 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-68913 ( R-HSA-68952 ) R-HSA-68913 Reaction Name: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68960 ( R-HSA-68962 ) R-HSA-68960 Reaction Name: DNA polymerase epsilon binds at the origin See in Reactome
MONDO:0014108	ERCC4	Q92889	3.1.-.-	R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-6783310 R-HSA-6783310 Reactome Name: Fanconi Anemia Pathway See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome	R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome	DNA Repair	R-HSA-109955 ( R-HSA-5696395 ) R-HSA-109955 Reaction Name: Formation of ERCC1:XPF heterodimeric complex See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6785732 ( R-HSA-6783310 ) R-HSA-6785732 Reaction Name: DNA nucleases bind monoubiquitinated ID2 complex See in Reactome R-HSA-6785986 ( R-HSA-6783310 ) R-HSA-6785986 Reaction Name: DNA nucleases unhook the interstrand crosslink (ICL) See in Reactome
MONDO:0014157	POLD1	P28340	3.1.11.- 2.7.7.7	R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5358606 R-HSA-5358606 Reactome Name: Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) See in Reactome R-HSA-5696397 R-HSA-5696397 Reactome Name: Gap-filling DNA repair synthesis and ligation in GG-NER See in Reactome R-HSA-69091 R-HSA-69091 Reactome Name: Polymerase switching See in Reactome R-HSA-110314 R-HSA-110314 Reactome Name: Recognition of DNA damage by PCNA-containing replication complex See in Reactome R-HSA-174414 R-HSA-174414 Reactome Name: Processive synthesis on the C-strand of the telomere See in Reactome R-HSA-174417 R-HSA-174417 Reactome Name: Telomere C-strand (Lagging Strand) Synthesis See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-174411 R-HSA-174411 Reactome Name: Polymerase switching on the C-strand of the telomere See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-174437 R-HSA-174437 Reactome Name: Removal of the Flap Intermediate from the C-strand See in Reactome R-HSA-5358565 R-HSA-5358565 Reactome Name: Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) See in Reactome R-HSA-5651801 R-HSA-5651801 Reactome Name: PCNA-Dependent Long Patch Base Excision Repair See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-2564830 R-HSA-2564830 Reactome Name: Cytosolic iron-sulfur cluster assembly See in Reactome R-HSA-69166 R-HSA-69166 Reactome Name: Removal of the Flap Intermediate See in Reactome R-HSA-5656169 R-HSA-5656169 Reactome Name: Termination of translesion DNA synthesis See in Reactome R-HSA-69183 R-HSA-69183 Reactome Name: Processive synthesis on the lagging strand See in Reactome	R-HSA-69109 R-HSA-69109 Reactome Name: Leading Strand Synthesis See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-69190 R-HSA-69190 Reactome Name: DNA strand elongation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-73886 R-HSA-73886 Reactome Name: Chromosome Maintenance See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-110373 R-HSA-110373 Reactome Name: Resolution of AP sites via the multiple-nucleotide patch replacement pathway See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-157579 R-HSA-157579 Reactome Name: Telomere Maintenance See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-5358508 R-HSA-5358508 Reactome Name: Mismatch Repair See in Reactome R-HSA-180786 R-HSA-180786 Reactome Name: Extension of Telomeres See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-69186 R-HSA-69186 Reactome Name: Lagging Strand Synthesis See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	Cell Cycle DNA Replication DNA Repair Metabolism	R-HSA-110363 ( R-HSA-5651801 ) R-HSA-110363 Reaction Name: FEN1 bound to PCNA and APEX1 cleaves flap ssDNA See in Reactome R-HSA-110364 ( R-HSA-5651801 ) R-HSA-110364 Reaction Name: PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 See in Reactome R-HSA-110368 ( R-HSA-5651801 ) R-HSA-110368 Reaction Name: POLD,POLE-mediated DNA strand displacement synthesis See in Reactome R-HSA-110371 ( R-HSA-5651801 ) R-HSA-110371 Reaction Name: LIG1 binds APEX1 and PCNA at SSB See in Reactome R-HSA-174438 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174438 Reaction Name: Formation of the Flap Intermediate on the C-strand See in Reactome R-HSA-174441 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174441 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand See in Reactome R-HSA-174444 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174444 Reaction Name: Formation of C-strand Okazaki fragments See in Reactome R-HSA-174445 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174445 Reaction Name: RPA binds to the Flap on the C-strand See in Reactome R-HSA-174446 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174446 Reaction Name: Removal of remaining Flap from the C-strand See in Reactome R-HSA-174448 ( R-HSA-174411; R-HSA-174417 ) R-HSA-174448 Reaction Name: Formation of Processive Complex on the C-strand of the telomere See in Reactome R-HSA-174451 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174451 Reaction Name: Recruitment of DNA2 endonuclease to the C strand See in Reactome R-HSA-174456 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174456 Reaction Name: Joining of adjacent Okazaki fragments of the C-strand See in Reactome R-HSA-176702 ( R-HSA-174417 ) R-HSA-176702 Reaction Name: Disassociation of Processive Complex and Completed Telomere End See in Reactome R-HSA-2564828 ( R-HSA-2564830 ) R-HSA-2564828 Reaction Name: CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins See in Reactome R-HSA-5358579 ( R-HSA-5358565; R-HSA-5358606 ) R-HSA-5358579 Reaction Name: DNA polymerase delta polymerizes DNA across single stranded gap See in Reactome R-HSA-5651805 ( R-HSA-5651801 ) R-HSA-5651805 Reaction Name: LIG1 bound to APEX1 and PCNA ligates SSB See in Reactome R-HSA-5651809 ( R-HSA-5651801 ) R-HSA-5651809 Reaction Name: LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA See in Reactome R-HSA-5651992 ( R-HSA-110314 ) R-HSA-5651992 Reaction Name: PCNA-containing replication complex binds damaged dsDNA See in Reactome R-HSA-5652005 ( R-HSA-110314 ) R-HSA-5652005 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA See in Reactome R-HSA-5652009 ( R-HSA-110314 ) R-HSA-5652009 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA See in Reactome R-HSA-5653838 ( R-HSA-5656169 ) R-HSA-5653838 Reaction Name: POLD,POLE binds deISGylated PCNA after TLS See in Reactome R-HSA-5653840 ( R-HSA-5656169 ) R-HSA-5653840 Reaction Name: POLD,POLE complete replication of damaged DNA after TLS See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690997 ( R-HSA-5696397 ) R-HSA-5690997 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in GG-NER See in Reactome R-HSA-5691001 ( R-HSA-5696397 ) R-HSA-5691001 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-6782208 ( R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-69074 ( R-HSA-69091 ) R-HSA-69074 Reaction Name: Formation of Processive Complex See in Reactome R-HSA-69116 ( R-HSA-69183 ) R-HSA-69116 Reaction Name: Formation of Okazaki fragments See in Reactome R-HSA-69127 ( R-HSA-69183 ) R-HSA-69127 Reaction Name: Formation of the Flap Intermediate See in Reactome R-HSA-69140 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69140 Reaction Name: RPA binds to the Flap See in Reactome R-HSA-69142 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69142 Reaction Name: Recruitment of Dna2 endonuclease See in Reactome R-HSA-69144 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69144 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 See in Reactome R-HSA-69152 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69152 Reaction Name: Removal of remaining Flap See in Reactome
MONDO:0014615	ERCC3	P19447	3.6.4.12	R-HSA-75955 R-HSA-75955 Reactome Name: RNA Polymerase II Transcription Elongation See in Reactome R-HSA-112382 R-HSA-112382 Reactome Name: Formation of RNA Pol II elongation complex See in Reactome R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-427413 R-HSA-427413 Reactome Name: NoRC negatively regulates rRNA expression See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-75953 R-HSA-75953 Reactome Name: RNA Polymerase II Transcription Initiation See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome R-HSA-73863 R-HSA-73863 Reactome Name: RNA Polymerase I Transcription Termination See in Reactome R-HSA-73776 R-HSA-73776 Reactome Name: RNA Polymerase II Promoter Escape See in Reactome R-HSA-73779 R-HSA-73779 Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening See in Reactome R-HSA-76042 R-HSA-76042 Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance See in Reactome R-HSA-77075 R-HSA-77075 Reactome Name: RNA Pol II CTD phosphorylation and interaction with CE See in Reactome R-HSA-73772 R-HSA-73772 Reactome Name: RNA Polymerase I Promoter Escape See in Reactome R-HSA-72086 R-HSA-72086 Reactome Name: mRNA Capping See in Reactome R-HSA-113418 R-HSA-113418 Reactome Name: Formation of the Early Elongation Complex See in Reactome R-HSA-674695 R-HSA-674695 Reactome Name: RNA Polymerase II Pre-transcription Events See in Reactome	R-HSA-5250941 R-HSA-5250941 Reactome Name: Negative epigenetic regulation of rRNA expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of RNA DNA Repair	R-HSA-109639 ( R-HSA-73779 ) R-HSA-109639 Reaction Name: Formation of the closed pre-initiation complex See in Reactome R-HSA-111264 ( R-HSA-73776; R-HSA-76042 ) R-HSA-111264 Reaction Name: Addition of nucleotides between position +11 and +30 See in Reactome R-HSA-112379 ( R-HSA-112382; R-HSA-75955 ) R-HSA-112379 Reaction Name: Recruitment of elongation factors to form elongation complex See in Reactome R-HSA-112383 ( R-HSA-113418; R-HSA-75955 ) R-HSA-112383 Reaction Name: Hypophosphorylation of RNA Pol II CTD by FCP1P protein See in Reactome R-HSA-112385 ( R-HSA-75955 ) R-HSA-112385 Reaction Name: Addition of nucleotides leads to transcript elongation See in Reactome R-HSA-113430 ( R-HSA-77075 ) R-HSA-113430 Reaction Name: Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex See in Reactome R-HSA-427366 ( R-HSA-427413 ) R-HSA-427366 Reaction Name: Transcription of intergenic spacer of the rRNA gene See in Reactome R-HSA-5689317 ( R-HSA-5696395 ) R-HSA-5689317 Reaction Name: Formation of the pre-incision complex in GG-NER See in Reactome R-HSA-5689861 ( R-HSA-5696395 ) R-HSA-5689861 Reaction Name: Recruitment of XPA and release of CAK See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-5690996 ( R-HSA-5696395 ) R-HSA-5690996 Reaction Name: ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA See in Reactome R-HSA-5691000 ( R-HSA-5696395 ) R-HSA-5691000 Reaction Name: TFIIH binds GG-NER site to form a verification complex See in Reactome R-HSA-5696670 ( R-HSA-5696395 ) R-HSA-5696670 Reaction Name: CHD1L is recruited to GG-NER site See in Reactome R-HSA-6781818 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781818 Reaction Name: RNA Pol II initiates transcription from damaged DNA template See in Reactome R-HSA-6781824 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781824 Reaction Name: Active RNA Pol II complex transcribes lesion-containing DNA template See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-6790454 ( R-HSA-5696395 ) R-HSA-6790454 Reaction Name: SUMOylation of XPC See in Reactome R-HSA-6790487 ( R-HSA-5696395 ) R-HSA-6790487 Reaction Name: RNF111 ubiquitinates SUMOylated XPC See in Reactome R-HSA-6797606 ( R-HSA-6796648 ) R-HSA-6797606 Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes See in Reactome R-HSA-6797616 ( R-HSA-6796648 ) R-HSA-6797616 Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes See in Reactome R-HSA-6797712 ( R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome R-HSA-73758 ( R-HSA-73762 ) R-HSA-73758 Reaction Name: Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter See in Reactome R-HSA-73769 ( R-HSA-73772 ) R-HSA-73769 Reaction Name: Loss of Rrn3 from RNA Polymerase I promoter escape complex See in Reactome R-HSA-73946 ( R-HSA-674695 ) R-HSA-73946 Reaction Name: Abortive initiation after formation of the first phosphodiester bond See in Reactome R-HSA-74986 ( R-HSA-73772 ) R-HSA-74986 Reaction Name: Elongation of pre-rRNA transcript See in Reactome R-HSA-74992 ( R-HSA-73863 ) R-HSA-74992 Reaction Name: Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box See in Reactome R-HSA-74993 ( R-HSA-73863 ) R-HSA-74993 Reaction Name: PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box See in Reactome R-HSA-74994 ( R-HSA-73863 ) R-HSA-74994 Reaction Name: Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box See in Reactome R-HSA-75850 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75850 Reaction Name: Addition of the third nucleotide on the nascent transcript See in Reactome R-HSA-75856 ( R-HSA-674695 ) R-HSA-75856 Reaction Name: Abortive Initiation Before Second Transition See in Reactome R-HSA-75861 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75861 Reaction Name: NTP Binds Active Site of RNA Polymerase II See in Reactome R-HSA-75862 ( R-HSA-674695 ) R-HSA-75862 Reaction Name: Fall Back to Closed Pre-initiation Complex See in Reactome R-HSA-75864 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75864 Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released See in Reactome R-HSA-75866 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75866 Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP See in Reactome R-HSA-75869 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75869 Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition See in Reactome R-HSA-75873 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75873 Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript See in Reactome R-HSA-75891 ( R-HSA-674695 ) R-HSA-75891 Reaction Name: Abortive Initiation After Second Transition See in Reactome R-HSA-75949 ( R-HSA-76042 ) R-HSA-75949 Reaction Name: RNA Polymerase II Promoter Opening: First Transition See in Reactome R-HSA-76576 ( R-HSA-73776; R-HSA-76042 ) R-HSA-76576 Reaction Name: Addition of nucleotides 10 and 11 on the growing transcript: Third Transition See in Reactome R-HSA-77068 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77068 Reaction Name: Activation of GT See in Reactome R-HSA-77069 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77069 Reaction Name: RNA Polymerase II CTD (phosphorylated) binds to CE See in Reactome R-HSA-77071 ( R-HSA-77075 ) R-HSA-77071 Reaction Name: Phosphorylation (Ser5) of RNA pol II CTD See in Reactome R-HSA-77073 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77073 Reaction Name: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) See in Reactome R-HSA-77077 ( R-HSA-72086 ) R-HSA-77077 Reaction Name: Capping complex formation See in Reactome R-HSA-77078 ( R-HSA-72086 ) R-HSA-77078 Reaction Name: Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme See in Reactome R-HSA-77081 ( R-HSA-72086 ) R-HSA-77081 Reaction Name: Formation of the CE:GMP intermediate complex See in Reactome R-HSA-77083 ( R-HSA-72086 ) R-HSA-77083 Reaction Name: Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA See in Reactome R-HSA-77085 ( R-HSA-72086 ) R-HSA-77085 Reaction Name: Dissociation of transcript with 5'-GMP from GT See in Reactome R-HSA-77090 ( R-HSA-72086 ) R-HSA-77090 Reaction Name: Methylation of GMP-cap by RNA Methyltransferase See in Reactome R-HSA-9613494 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613494 Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition See in Reactome R-HSA-9613497 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613497 Reaction Name: Unwinding DNA for the nascent transcript See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome
MONDO:0014696	ERCC5	P28715	3.1.-.-	R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome	R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome	DNA Repair	R-HSA-5689317 ( R-HSA-5696395 ) R-HSA-5689317 Reaction Name: Formation of the pre-incision complex in GG-NER See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome
MONDO:0014805	USP7	Q93009	3.4.19.12	R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8866652 R-HSA-8866652 Reactome Name: Synthesis of active ubiquitin: roles of E1 and E2 enzymes See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of proteins DNA Repair Signal Transduction	R-HSA-3215295 ( R-HSA-6804757 ) R-HSA-3215295 Reaction Name: USP7 deubiquitinates MDM2 See in Reactome R-HSA-3215310 ( R-HSA-6804757 ) R-HSA-3215310 Reaction Name: USP7 deubiquitinates TP53 and counteracts MDM2 See in Reactome R-HSA-3222072 ( R-HSA-6804757 ) R-HSA-3222072 Reaction Name: DAXX binds Ub-MDM2 and USP7 See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-6807118 ( R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-8853503 ( R-HSA-8866652 ) R-HSA-8853503 Reaction Name: UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin See in Reactome R-HSA-8853514 ( R-HSA-8866652 ) R-HSA-8853514 Reaction Name: UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome
MONDO:0014843	ERCC6	Q03468	3.6.4.-	R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-427389 R-HSA-427389 Reactome Name: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome	R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome	Gene expression (Transcription) DNA Repair	R-HSA-427336 ( R-HSA-427389 ) R-HSA-427336 Reaction Name: TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9. See in Reactome R-HSA-427404 ( R-HSA-427389 ) R-HSA-427404 Reaction Name: Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-5250947 ( R-HSA-5250924 ) R-HSA-5250947 Reaction Name: B-WICH complex binds rDNA promoter See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-73739 ( R-HSA-73762 ) R-HSA-73739 Reaction Name: Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome
MONDO:0018653	POLD1	P28340	3.1.11.- 2.7.7.7	R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5358606 R-HSA-5358606 Reactome Name: Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) See in Reactome R-HSA-5696397 R-HSA-5696397 Reactome Name: Gap-filling DNA repair synthesis and ligation in GG-NER See in Reactome R-HSA-69091 R-HSA-69091 Reactome Name: Polymerase switching See in Reactome R-HSA-110314 R-HSA-110314 Reactome Name: Recognition of DNA damage by PCNA-containing replication complex See in Reactome R-HSA-174414 R-HSA-174414 Reactome Name: Processive synthesis on the C-strand of the telomere See in Reactome R-HSA-174417 R-HSA-174417 Reactome Name: Telomere C-strand (Lagging Strand) Synthesis See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-174411 R-HSA-174411 Reactome Name: Polymerase switching on the C-strand of the telomere See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-174437 R-HSA-174437 Reactome Name: Removal of the Flap Intermediate from the C-strand See in Reactome R-HSA-5358565 R-HSA-5358565 Reactome Name: Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) See in Reactome R-HSA-5651801 R-HSA-5651801 Reactome Name: PCNA-Dependent Long Patch Base Excision Repair See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-2564830 R-HSA-2564830 Reactome Name: Cytosolic iron-sulfur cluster assembly See in Reactome R-HSA-69166 R-HSA-69166 Reactome Name: Removal of the Flap Intermediate See in Reactome R-HSA-5656169 R-HSA-5656169 Reactome Name: Termination of translesion DNA synthesis See in Reactome R-HSA-69183 R-HSA-69183 Reactome Name: Processive synthesis on the lagging strand See in Reactome	R-HSA-69109 R-HSA-69109 Reactome Name: Leading Strand Synthesis See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-69190 R-HSA-69190 Reactome Name: DNA strand elongation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-73886 R-HSA-73886 Reactome Name: Chromosome Maintenance See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-110373 R-HSA-110373 Reactome Name: Resolution of AP sites via the multiple-nucleotide patch replacement pathway See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-157579 R-HSA-157579 Reactome Name: Telomere Maintenance See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-5358508 R-HSA-5358508 Reactome Name: Mismatch Repair See in Reactome R-HSA-180786 R-HSA-180786 Reactome Name: Extension of Telomeres See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-69186 R-HSA-69186 Reactome Name: Lagging Strand Synthesis See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	Cell Cycle DNA Replication DNA Repair Metabolism	R-HSA-110363 ( R-HSA-5651801 ) R-HSA-110363 Reaction Name: FEN1 bound to PCNA and APEX1 cleaves flap ssDNA See in Reactome R-HSA-110364 ( R-HSA-5651801 ) R-HSA-110364 Reaction Name: PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 See in Reactome R-HSA-110368 ( R-HSA-5651801 ) R-HSA-110368 Reaction Name: POLD,POLE-mediated DNA strand displacement synthesis See in Reactome R-HSA-110371 ( R-HSA-5651801 ) R-HSA-110371 Reaction Name: LIG1 binds APEX1 and PCNA at SSB See in Reactome R-HSA-174438 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174438 Reaction Name: Formation of the Flap Intermediate on the C-strand See in Reactome R-HSA-174441 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174441 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand See in Reactome R-HSA-174444 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174444 Reaction Name: Formation of C-strand Okazaki fragments See in Reactome R-HSA-174445 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174445 Reaction Name: RPA binds to the Flap on the C-strand See in Reactome R-HSA-174446 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174446 Reaction Name: Removal of remaining Flap from the C-strand See in Reactome R-HSA-174448 ( R-HSA-174411; R-HSA-174417 ) R-HSA-174448 Reaction Name: Formation of Processive Complex on the C-strand of the telomere See in Reactome R-HSA-174451 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174451 Reaction Name: Recruitment of DNA2 endonuclease to the C strand See in Reactome R-HSA-174456 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174456 Reaction Name: Joining of adjacent Okazaki fragments of the C-strand See in Reactome R-HSA-176702 ( R-HSA-174417 ) R-HSA-176702 Reaction Name: Disassociation of Processive Complex and Completed Telomere End See in Reactome R-HSA-2564828 ( R-HSA-2564830 ) R-HSA-2564828 Reaction Name: CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins See in Reactome R-HSA-5358579 ( R-HSA-5358565; R-HSA-5358606 ) R-HSA-5358579 Reaction Name: DNA polymerase delta polymerizes DNA across single stranded gap See in Reactome R-HSA-5651805 ( R-HSA-5651801 ) R-HSA-5651805 Reaction Name: LIG1 bound to APEX1 and PCNA ligates SSB See in Reactome R-HSA-5651809 ( R-HSA-5651801 ) R-HSA-5651809 Reaction Name: LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA See in Reactome R-HSA-5651992 ( R-HSA-110314 ) R-HSA-5651992 Reaction Name: PCNA-containing replication complex binds damaged dsDNA See in Reactome R-HSA-5652005 ( R-HSA-110314 ) R-HSA-5652005 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA See in Reactome R-HSA-5652009 ( R-HSA-110314 ) R-HSA-5652009 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA See in Reactome R-HSA-5653838 ( R-HSA-5656169 ) R-HSA-5653838 Reaction Name: POLD,POLE binds deISGylated PCNA after TLS See in Reactome R-HSA-5653840 ( R-HSA-5656169 ) R-HSA-5653840 Reaction Name: POLD,POLE complete replication of damaged DNA after TLS See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690997 ( R-HSA-5696397 ) R-HSA-5690997 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in GG-NER See in Reactome R-HSA-5691001 ( R-HSA-5696397 ) R-HSA-5691001 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-6782208 ( R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-69074 ( R-HSA-69091 ) R-HSA-69074 Reaction Name: Formation of Processive Complex See in Reactome R-HSA-69116 ( R-HSA-69183 ) R-HSA-69116 Reaction Name: Formation of Okazaki fragments See in Reactome R-HSA-69127 ( R-HSA-69183 ) R-HSA-69127 Reaction Name: Formation of the Flap Intermediate See in Reactome R-HSA-69140 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69140 Reaction Name: RPA binds to the Flap See in Reactome R-HSA-69142 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69142 Reaction Name: Recruitment of Dna2 endonuclease See in Reactome R-HSA-69144 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69144 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 See in Reactome R-HSA-69152 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69152 Reaction Name: Removal of remaining Flap See in Reactome
MONDO:0018653	POLE	Q07864	3.1.11.- 2.7.7.7	R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-5696397 R-HSA-5696397 Reactome Name: Gap-filling DNA repair synthesis and ligation in GG-NER See in Reactome R-HSA-68952 R-HSA-68952 Reactome Name: DNA replication initiation See in Reactome R-HSA-110314 R-HSA-110314 Reactome Name: Recognition of DNA damage by PCNA-containing replication complex See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5651801 R-HSA-5651801 Reactome Name: PCNA-Dependent Long Patch Base Excision Repair See in Reactome R-HSA-5656169 R-HSA-5656169 Reactome Name: Termination of translesion DNA synthesis See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-110373 R-HSA-110373 Reactome Name: Resolution of AP sites via the multiple-nucleotide patch replacement pathway See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	DNA Repair DNA Replication Cell Cycle	R-HSA-110363 ( R-HSA-5651801 ) R-HSA-110363 Reaction Name: FEN1 bound to PCNA and APEX1 cleaves flap ssDNA See in Reactome R-HSA-110364 ( R-HSA-5651801 ) R-HSA-110364 Reaction Name: PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 See in Reactome R-HSA-110368 ( R-HSA-5651801 ) R-HSA-110368 Reaction Name: POLD,POLE-mediated DNA strand displacement synthesis See in Reactome R-HSA-110371 ( R-HSA-5651801 ) R-HSA-110371 Reaction Name: LIG1 binds APEX1 and PCNA at SSB See in Reactome R-HSA-5651805 ( R-HSA-5651801 ) R-HSA-5651805 Reaction Name: LIG1 bound to APEX1 and PCNA ligates SSB See in Reactome R-HSA-5651809 ( R-HSA-5651801 ) R-HSA-5651809 Reaction Name: LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA See in Reactome R-HSA-5651992 ( R-HSA-110314 ) R-HSA-5651992 Reaction Name: PCNA-containing replication complex binds damaged dsDNA See in Reactome R-HSA-5652005 ( R-HSA-110314 ) R-HSA-5652005 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA See in Reactome R-HSA-5652009 ( R-HSA-110314 ) R-HSA-5652009 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA See in Reactome R-HSA-5653838 ( R-HSA-5656169 ) R-HSA-5653838 Reaction Name: POLD,POLE binds deISGylated PCNA after TLS See in Reactome R-HSA-5653840 ( R-HSA-5656169 ) R-HSA-5653840 Reaction Name: POLD,POLE complete replication of damaged DNA after TLS See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690997 ( R-HSA-5696397 ) R-HSA-5690997 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in GG-NER See in Reactome R-HSA-5691001 ( R-HSA-5696397 ) R-HSA-5691001 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-68913 ( R-HSA-68952 ) R-HSA-68913 Reaction Name: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68960 ( R-HSA-68962 ) R-HSA-68960 Reaction Name: DNA polymerase epsilon binds at the origin See in Reactome
MONDO:0019086	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0019569	ERCC6	Q03468	3.6.4.-	R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-427389 R-HSA-427389 Reactome Name: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome	R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome	Gene expression (Transcription) DNA Repair	R-HSA-427336 ( R-HSA-427389 ) R-HSA-427336 Reaction Name: TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9. See in Reactome R-HSA-427404 ( R-HSA-427389 ) R-HSA-427404 Reaction Name: Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-5250947 ( R-HSA-5250924 ) R-HSA-5250947 Reaction Name: B-WICH complex binds rDNA promoter See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-73739 ( R-HSA-73762 ) R-HSA-73739 Reaction Name: Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome
MONDO:0019569	ERCC4	Q92889	3.1.-.-	R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-6783310 R-HSA-6783310 Reactome Name: Fanconi Anemia Pathway See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome	R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome	DNA Repair	R-HSA-109955 ( R-HSA-5696395 ) R-HSA-109955 Reaction Name: Formation of ERCC1:XPF heterodimeric complex See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6785732 ( R-HSA-6783310 ) R-HSA-6785732 Reaction Name: DNA nucleases bind monoubiquitinated ID2 complex See in Reactome R-HSA-6785986 ( R-HSA-6783310 ) R-HSA-6785986 Reaction Name: DNA nucleases unhook the interstrand crosslink (ICL) See in Reactome
MONDO:0019570	ERCC6	Q03468	3.6.4.-	R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-427389 R-HSA-427389 Reactome Name: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome	R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome	Gene expression (Transcription) DNA Repair	R-HSA-427336 ( R-HSA-427389 ) R-HSA-427336 Reaction Name: TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9. See in Reactome R-HSA-427404 ( R-HSA-427389 ) R-HSA-427404 Reaction Name: Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-5250947 ( R-HSA-5250924 ) R-HSA-5250947 Reaction Name: B-WICH complex binds rDNA promoter See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-73739 ( R-HSA-73762 ) R-HSA-73739 Reaction Name: Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome
MONDO:0020769	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0021230	EP300	Q09472	2.3.1.- 2.3.1.48	R-HSA-9617629 R-HSA-9617629 Reactome Name: Regulation of FOXO transcriptional activity by acetylation See in Reactome R-HSA-210744 R-HSA-210744 Reactome Name: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells See in Reactome R-HSA-5689901 R-HSA-5689901 Reactome Name: Metalloprotease DUBs See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-9616222 R-HSA-9616222 Reactome Name: Transcriptional regulation of granulopoiesis See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-8941856 R-HSA-8941856 Reactome Name: RUNX3 regulates NOTCH signaling See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-6804114 R-HSA-6804114 Reactome Name: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest See in Reactome R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-156711 R-HSA-156711 Reactome Name: Polo-like kinase mediated events See in Reactome R-HSA-5250924 R-HSA-5250924 Reactome Name: B-WICH complex positively regulates rRNA expression See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9013508 R-HSA-9013508 Reactome Name: NOTCH3 Intracellular Domain Regulates Transcription See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-3371568 R-HSA-3371568 Reactome Name: Attenuation phase See in Reactome R-HSA-8866907 R-HSA-8866907 Reactome Name: Activation of the TFAP2 (AP-2) family of transcription factors See in Reactome R-HSA-9614657 R-HSA-9614657 Reactome Name: FOXO-mediated transcription of cell death genes See in Reactome R-HSA-9701898 R-HSA-9701898 Reactome Name: STAT3 nuclear events downstream of ALK signaling See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-1234158 R-HSA-1234158 Reactome Name: Regulation of gene expression by Hypoxia-inducible Factor See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-8936459 R-HSA-8936459 Reactome Name: RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-2197563 R-HSA-2197563 Reactome Name: NOTCH2 intracellular domain regulates transcription See in Reactome R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-3134973 R-HSA-3134973 Reactome Name: LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-6811555 R-HSA-6811555 Reactome Name: PI5P Regulates TP53 Acetylation See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-6791312 R-HSA-6791312 Reactome Name: TP53 Regulates Transcription of Cell Cycle Genes See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome	Circadian Clock Immune System Cell Cycle Developmental Biology Metabolism Gene expression (Transcription) DNA Repair Cellular responses to stimuli Metabolism of proteins Chromatin organization Signal Transduction	R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-9760081 () R-HSA-9760081 Reaction Name: CREBBP, EP300 acetylates NFE2L2 See in Reactome R-HSA-9011981 ( R-HSA-9018519 ) R-HSA-9011981 Reaction Name: EP300 is recruited to MYC and BCL2 genes See in Reactome R-HSA-8878050 ( R-HSA-8939243 ) R-HSA-8878050 Reaction Name: HIPK2 phosphorylates RUNX1 and EP300 See in Reactome R-HSA-9761836 () R-HSA-9761836 Reaction Name: p14ARF binds NFE2L2:CREBBP, EP300 See in Reactome R-HSA-560491 ( R-HSA-381340 ) R-HSA-560491 Reaction Name: Expression of CEBPA See in Reactome R-HSA-4396371 ( R-HSA-2122947 ) R-HSA-4396371 Reaction Name: NOTCH1 Coactivator Complex binds MYC promoter See in Reactome R-HSA-9038052 ( R-HSA-9018519 ) R-HSA-9038052 Reaction Name: GREB1 binds ESR1:ESTG and co-activators See in Reactome R-HSA-8952101 ( R-HSA-8951936 ) R-HSA-8952101 Reaction Name: p14-ARF transcription is stimulated by RUNX proteins See in Reactome R-HSA-1234167 ( R-HSA-1234158 ) R-HSA-1234167 Reaction Name: Formation of HIF:CBP:p300 complex at promoters See in Reactome R-HSA-9617758 ( R-HSA-9617629 ) R-HSA-9617758 Reaction Name: EP300,CREBBP acetylate FOXO4 See in Reactome R-HSA-9038163 ( R-HSA-9018519 ) R-HSA-9038163 Reaction Name: ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators See in Reactome R-HSA-9016751 ( R-HSA-9013508 ) R-HSA-9016751 Reaction Name: FABP7 gene expression is positively regulated by NOTCH1 and NOTCH3 See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-560498 ( R-HSA-381340 ) R-HSA-560498 Reaction Name: Expression of Lipoprotein lipase (LPL) See in Reactome R-HSA-1980065 ( R-HSA-2122947 ) R-HSA-1980065 Reaction Name: NOTCH1 stimulates HEY transcription See in Reactome R-HSA-9759332 () R-HSA-9759332 Reaction Name: AcK-NFE2L2 binds the TXNRD1 promoter See in Reactome R-HSA-9613451 ( R-HSA-9031628 ) R-HSA-9613451 Reaction Name: p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes See in Reactome R-HSA-8936621 ( R-HSA-8936459 ) R-HSA-8936621 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter See in Reactome R-HSA-5628871 ( R-HSA-6804758 ) R-HSA-5628871 Reaction Name: BRD7 promotes EP300-mediated acetylation of TP53 See in Reactome R-HSA-1980067 ( R-HSA-2122947 ) R-HSA-1980067 Reaction Name: NOTCH1 stimulates MYC transcription See in Reactome R-HSA-9620723 ( R-HSA-9031628 ) R-HSA-9620723 Reaction Name: VGF gene expression See in Reactome R-HSA-5250938 ( R-HSA-5250924 ) R-HSA-5250938 Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-9761849 () R-HSA-9761849 Reaction Name: AcK-NFE2L2-dependent P6GD gene expression See in Reactome R-HSA-9023884 ( R-HSA-9018519 ) R-HSA-9023884 Reaction Name: NCOA1 recruits EP300 to TGFA promoter See in Reactome R-HSA-8937050 ( R-HSA-8936459 ) R-HSA-8937050 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter See in Reactome R-HSA-8952081 ( R-HSA-8951936 ) R-HSA-8952081 Reaction Name: RUNX proteins bind the p14-ARF promoter at the CDKN2A locus See in Reactome R-HSA-3662335 ( R-HSA-3214847 ) R-HSA-3662335 Reaction Name: EP300 acetylates histone H2A, H2B, H3, H4 See in Reactome R-HSA-1183003 ( R-HSA-381340 ) R-HSA-1183003 Reaction Name: Expression of Leptin See in Reactome R-HSA-6804379 ( R-HSA-6804760 ) R-HSA-6804379 Reaction Name: PRMT5 binds TTC5 See in Reactome R-HSA-4088162 ( R-HSA-156711 ) R-HSA-4088162 Reaction Name: FOXM1 binds CDC25A promoter See in Reactome R-HSA-3134883 ( R-HSA-3134973 ) R-HSA-3134883 Reaction Name: Beta-catenin enhances association of IRF3 with CBP/p300 See in Reactome R-HSA-381309 ( R-HSA-381340 ) R-HSA-381309 Reaction Name: PPARG:RXRA heterodimer binds to fatty acid-like ligands See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome R-HSA-1028820 ( R-HSA-933541 ) R-HSA-1028820 Reaction Name: Formation of VAF (virus-activated factor) complex See in Reactome R-HSA-8878243 ( R-HSA-8941856 ) R-HSA-8878243 Reaction Name: HES1 gene transcription is inhibited by RUNX3 See in Reactome R-HSA-9021450 ( R-HSA-9013508 ) R-HSA-9021450 Reaction Name: PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes See in Reactome R-HSA-9761828 () R-HSA-9761828 Reaction Name: NFE2L2 binds the PGD gene See in Reactome R-HSA-1028817 ( R-HSA-918233 ) R-HSA-1028817 Reaction Name: CREBBP, EP300 binds p-T,4S-IRF3:p-T,4S-IRF3 See in Reactome R-HSA-9008315 ( R-HSA-9018519 ) R-HSA-9008315 Reaction Name: TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen See in Reactome R-HSA-8936628 ( R-HSA-8936459 ) R-HSA-8936628 Reaction Name: GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome R-HSA-9761846 () R-HSA-9761846 Reaction Name: NFE2L2-dependent PGD gene expression See in Reactome R-HSA-8936481 ( R-HSA-8936459 ) R-HSA-8936481 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter See in Reactome R-HSA-5663264 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663264 Reaction Name: RORA, EP300 bind CPT1A gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-4396347 ( R-HSA-2122947; R-HSA-8941856 ) R-HSA-4396347 Reaction Name: NOTCH1 Coactivator Complex binds HES1 promoter See in Reactome R-HSA-9759141 () R-HSA-9759141 Reaction Name: AcK-NFE2L2 and MAFK bind NQO1 gene See in Reactome R-HSA-9760125 () R-HSA-9760125 Reaction Name: AcK-NFE2L2-dependent GCLM gene expression See in Reactome R-HSA-9613460 ( R-HSA-9031628 ) R-HSA-9613460 Reaction Name: ID1 and ID3 gene expression See in Reactome R-HSA-9620717 ( R-HSA-9031628 ) R-HSA-9620717 Reaction Name: p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter See in Reactome R-HSA-8951951 ( R-HSA-8951936 ) R-HSA-8951951 Reaction Name: RUNX3 binds EP300 See in Reactome R-HSA-9029561 ( R-HSA-9029569 ) R-HSA-9029561 Reaction Name: NCOA1 recruits EP300 to the ABCA1 promoter See in Reactome R-HSA-560473 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560473 Reaction Name: Expression of ANGPTL4 See in Reactome R-HSA-9622604 ( R-HSA-9614657 ) R-HSA-9622604 Reaction Name: BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y See in Reactome R-HSA-9617064 ( R-HSA-9616222 ) R-HSA-9617064 Reaction Name: SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene See in Reactome R-HSA-9008285 ( R-HSA-9018519 ) R-HSA-9008285 Reaction Name: NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 See in Reactome R-HSA-3371554 ( R-HSA-3371568 ) R-HSA-3371554 Reaction Name: HSF1 acetylation at Lys80 See in Reactome R-HSA-9701531 ( R-HSA-9701898 ) R-HSA-9701531 Reaction Name: p-Y705,S727 STAT3 is acetylated See in Reactome R-HSA-9017835 ( R-HSA-1912408 ) R-HSA-9017835 Reaction Name: NOTCH1 coactivator complex binds NOTCH3 gene See in Reactome R-HSA-8937097 ( R-HSA-8936459 ) R-HSA-8937097 Reaction Name: MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-8936616 ( R-HSA-8936459 ) R-HSA-8936616 Reaction Name: RUNX1 and GATA1 bind the promoter of the GP1BA gene See in Reactome R-HSA-5663246 ( R-HSA-400253 ) R-HSA-5663246 Reaction Name: RORA, EP300 bind NPAS2 gene See in Reactome R-HSA-6804229 ( R-HSA-6804760 ) R-HSA-6804229 Reaction Name: JMY, TTC5 and EP300 bind See in Reactome R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781; R-HSA-400253 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-8878056 ( R-HSA-8939243 ) R-HSA-8878056 Reaction Name: RUNX1:CBFB binds EP300 See in Reactome R-HSA-9761812 () R-HSA-9761812 Reaction Name: AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD See in Reactome R-HSA-4396382 ( R-HSA-2122947 ) R-HSA-4396382 Reaction Name: NOTCH1 Coactivator Complex binds promoters of HEY genes See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-560510 ( R-HSA-381340 ) R-HSA-560510 Reaction Name: Expression of FABP4 (aP2) See in Reactome R-HSA-9760097 () R-HSA-9760097 Reaction Name: AcK-NFE2L2 and MAFK bind the GSTA1 gene See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-5250930 ( R-HSA-5250924 ) R-HSA-5250930 Reaction Name: B-WICH recruits histone acetyltransferases See in Reactome R-HSA-8937016 ( R-HSA-8936459 ) R-HSA-8937016 Reaction Name: Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter See in Reactome R-HSA-400342 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-400342 Reaction Name: Expression of ARNTL (BMAL1) See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-8952058 ( R-HSA-8951936 ) R-HSA-8952058 Reaction Name: CCND1 binds RUNX3 and displaces EP300 See in Reactome R-HSA-1980047 ( R-HSA-210744; R-HSA-2122947; R-HSA-8941856 ) R-HSA-1980047 Reaction Name: NOTCH1 stimulates HES1 transcription See in Reactome R-HSA-1235037 ( R-HSA-1234158 ) R-HSA-1235037 Reaction Name: Expression of VEGFA See in Reactome R-HSA-8878237 ( R-HSA-8941856 ) R-HSA-8878237 Reaction Name: RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter See in Reactome R-HSA-9622579 ( R-HSA-9614657 ) R-HSA-9622579 Reaction Name: FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter See in Reactome R-HSA-9620515 ( R-HSA-9617629 ) R-HSA-9620515 Reaction Name: KAT2B,EP300 acetylate FOXO3 under oxidative stress See in Reactome R-HSA-933536 ( R-HSA-933541 ) R-HSA-933536 Reaction Name: p-IRF7 dimer interacts with coactivator CBP/p300 See in Reactome R-HSA-9760128 () R-HSA-9760128 Reaction Name: AcK-NFE2L2-dependent GSTA1 gene expression See in Reactome R-HSA-9617683 ( R-HSA-9617629 ) R-HSA-9617683 Reaction Name: EP300,CREBBP bind SOH-C481-FOXO4 See in Reactome R-HSA-1912415 ( R-HSA-1912408 ) R-HSA-1912415 Reaction Name: NOTCH3 gene transcription See in Reactome R-HSA-1028812 ( R-HSA-918233 ) R-HSA-1028812 Reaction Name: Expression of interferon-beta See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-9760082 () R-HSA-9760082 Reaction Name: NFE2L2 binds CREBBP,EP300 See in Reactome R-HSA-1912394 ( R-HSA-2122947 ) R-HSA-1912394 Reaction Name: NICD1 in complex with RBPJ (CSL) recruits MAML See in Reactome R-HSA-560493 ( R-HSA-381340 ) R-HSA-560493 Reaction Name: Expression of Perilipin (PLIN) See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-1912393 ( R-HSA-2122947 ) R-HSA-1912393 Reaction Name: MAML in complex with NICD1 recruits CDK8 See in Reactome R-HSA-8935731 ( R-HSA-8936459 ) R-HSA-8935731 Reaction Name: ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-5663293 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-5663293 Reaction Name: RORA, EP300 bind SREBF1 gene See in Reactome R-HSA-1028819 ( R-HSA-933541 ) R-HSA-1028819 Reaction Name: VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes See in Reactome R-HSA-5660666 ( R-HSA-5621575 ) R-HSA-5660666 Reaction Name: CBP and p300 binds NF-kB complex See in Reactome R-HSA-1912416 ( R-HSA-1912408 ) R-HSA-1912416 Reaction Name: NOTCH1 gene transcription See in Reactome R-HSA-1912391 ( R-HSA-2122947 ) R-HSA-1912391 Reaction Name: NICD1 is phosphorylated by CDK8 See in Reactome R-HSA-9761815 () R-HSA-9761815 Reaction Name: AcK-NFE2L2 and ATF4 bind the SLC7A11 gene See in Reactome R-HSA-549475 ( R-HSA-400253; R-HSA-9707616 ) R-HSA-549475 Reaction Name: Expression of NR1D1 (REV-ERBA) See in Reactome R-HSA-9760122 () R-HSA-9760122 Reaction Name: AcK-NFE2L2-dependent GCLC gene expression See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6811508 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811508 Reaction Name: ING2-bound EP300 acetylates TP53 See in Reactome R-HSA-1235035 ( R-HSA-1234158 ) R-HSA-1235035 Reaction Name: Expression of Carbonic Anhydrase IX (CA9) See in Reactome R-HSA-9021451 ( R-HSA-9013508 ) R-HSA-9021451 Reaction Name: NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter See in Reactome R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9023840 ( R-HSA-9018519 ) R-HSA-9023840 Reaction Name: HATs and coactivators are recruited to the CTSD gene See in Reactome R-HSA-6811479 ( R-HSA-6804758; R-HSA-6811555 ) R-HSA-6811479 Reaction Name: ING2 recruits EP300 to TP53 See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-8864307 ( R-HSA-8866907 ) R-HSA-8864307 Reaction Name: TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP See in Reactome R-HSA-1028815 ( R-HSA-918233 ) R-HSA-1028815 Reaction Name: p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta See in Reactome R-HSA-6804383 ( R-HSA-6804760 ) R-HSA-6804383 Reaction Name: PRMT5 methylates TP53 See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-9011975 ( R-HSA-9018519 ) R-HSA-9011975 Reaction Name: Estrogen-responsive MYC gene expression See in Reactome R-HSA-8878220 ( R-HSA-8941856 ) R-HSA-8878220 Reaction Name: RUNX3 binds the NOTCH1 coactivator complex See in Reactome R-HSA-2976551 ( R-HSA-2197563 ) R-HSA-2976551 Reaction Name: NOTCH2 stimulates GZMB transcription See in Reactome R-HSA-1368081 ( R-HSA-1368082; R-HSA-400253 ) R-HSA-1368081 Reaction Name: Expression of SREBF1 (SREBP1) See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-1980078 ( R-HSA-2122947 ) R-HSA-1980078 Reaction Name: NOTCH1 stimulates HES5 transcription See in Reactome R-HSA-4396379 ( R-HSA-2122947 ) R-HSA-4396379 Reaction Name: NOTCH1 Coactivator Complex binds HES5 promoter See in Reactome R-HSA-3215152 ( R-HSA-6804114 ) R-HSA-3215152 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter See in Reactome R-HSA-4088152 ( R-HSA-156711 ) R-HSA-4088152 Reaction Name: FOXM1 stimulates CDC25A transcription See in Reactome R-HSA-9009371 ( R-HSA-9018519 ) R-HSA-9009371 Reaction Name: Binding of AP1 transcriptional activator complexes to CCND1 promoter See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-1368087 ( R-HSA-400253 ) R-HSA-1368087 Reaction Name: RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene See in Reactome R-HSA-1368065 ( R-HSA-1989781; R-HSA-400253; R-HSA-9707616 ) R-HSA-1368065 Reaction Name: Expression of NPAS2 See in Reactome R-HSA-1183058 ( R-HSA-381340 ) R-HSA-1183058 Reaction Name: Expression of Adiponectin See in Reactome R-HSA-9622572 ( R-HSA-9614657 ) R-HSA-9622572 Reaction Name: NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter See in Reactome R-HSA-3899291 ( R-HSA-3899300 ) R-HSA-3899291 Reaction Name: SUMOylation of EP300 with SUMO1 See in Reactome R-HSA-9634433 ( R-HSA-9616222 ) R-HSA-9634433 Reaction Name: CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid See in Reactome R-HSA-9605057 ( R-HSA-9029569 ) R-HSA-9605057 Reaction Name: ABCA1 gene transcription regulated by NR1H2 or NR1H3 See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-9761841 () R-HSA-9761841 Reaction Name: AcK-NFE2L2-dependent SLC7A11 expression See in Reactome R-HSA-5691381 ( R-HSA-5689901 ) R-HSA-5691381 Reaction Name: MYSM1 deubiquitinates Histone H2A See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-9760099 () R-HSA-9760099 Reaction Name: AcK-NFE2L2 binds the GCLC gene See in Reactome R-HSA-9018499 ( R-HSA-9018519 ) R-HSA-9018499 Reaction Name: ESR1:ESTG and EP300 are recruited to TFF3 promoter See in Reactome R-HSA-9760103 () R-HSA-9760103 Reaction Name: AcK-NFE2L2 binds the GCLM gene See in Reactome R-HSA-560472 ( R-HSA-381340 ) R-HSA-560472 Reaction Name: Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-8935740 ( R-HSA-8936459 ) R-HSA-8935740 Reaction Name: RUNX1 and GATA1 bind the promoter of the ITGA2B gene See in Reactome R-HSA-9009378 ( R-HSA-9018519 ) R-HSA-9009378 Reaction Name: Estrogen-responsive CCND1 gene expression See in Reactome R-HSA-8952419 ( R-HSA-8941858 ) R-HSA-8952419 Reaction Name: SMURFs ubiquitinate RUNX3 See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-8936979 ( R-HSA-8936459 ) R-HSA-8936979 Reaction Name: RUNX1 and GATA1 bind the promoter of the THBS1 gene See in Reactome R-HSA-1235070 ( R-HSA-1234158 ) R-HSA-1235070 Reaction Name: Expression of Erythropoietin (EPO) See in Reactome R-HSA-5660660 ( R-HSA-5621575 ) R-HSA-5660660 Reaction Name: p300 acetylates RELA subunit See in Reactome R-HSA-3215144 ( R-HSA-6804114 ) R-HSA-3215144 Reaction Name: TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription See in Reactome R-HSA-8951966 ( R-HSA-8951936 ) R-HSA-8951966 Reaction Name: EP300 acetylates RUNX3 See in Reactome R-HSA-9008271 ( R-HSA-9018519 ) R-HSA-9008271 Reaction Name: CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter See in Reactome R-HSA-9011941 ( R-HSA-9018519 ) R-HSA-9011941 Reaction Name: Estrogen-responsive BCL2 gene expression See in Reactome R-HSA-2976563 ( R-HSA-2197563 ) R-HSA-2976563 Reaction Name: NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter See in Reactome R-HSA-5663273 ( R-HSA-400253 ) R-HSA-5663273 Reaction Name: RORA, EP300, PPARGC1A bind NR1D1 gene See in Reactome R-HSA-9604499 ( R-HSA-933541 ) R-HSA-9604499 Reaction Name: Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 See in Reactome R-HSA-9604664 ( R-HSA-9013695 ) R-HSA-9604664 Reaction Name: ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-8937037 ( R-HSA-8936459 ) R-HSA-8937037 Reaction Name: RUNX1 and GATA1 bind the promoter of the MIR27A gene See in Reactome R-HSA-9759364 () R-HSA-9759364 Reaction Name: AcK-NFE2L2-dependent TXNRD1 gene expression See in Reactome R-HSA-9617735 ( R-HSA-9617629 ) R-HSA-9617735 Reaction Name: TXN disrupts FOXO4 complex with EP300 See in Reactome R-HSA-3322427 ( R-HSA-201722 ) R-HSA-3322427 Reaction Name: Beta-catenin recruits CBP/p300 See in Reactome R-HSA-9018497 ( R-HSA-9018519 ) R-HSA-9018497 Reaction Name: Estrogen-responsive TFF3 gene expression See in Reactome R-HSA-8936995 ( R-HSA-8936459 ) R-HSA-8936995 Reaction Name: THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6804242 ( R-HSA-6804760 ) R-HSA-6804242 Reaction Name: TP53 binds the complex of JMY, EP300 and TTC5 See in Reactome R-HSA-9759186 () R-HSA-9759186 Reaction Name: AcK-NFE2L2- dependent NQO1 gene expression See in Reactome R-HSA-3222093 ( R-HSA-6804758 ) R-HSA-3222093 Reaction Name: BRD7 binds TP53 and EP300 See in Reactome
MONDO:0032684	POLE	Q07864	3.1.11.- 2.7.7.7	R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-5696397 R-HSA-5696397 Reactome Name: Gap-filling DNA repair synthesis and ligation in GG-NER See in Reactome R-HSA-68952 R-HSA-68952 Reactome Name: DNA replication initiation See in Reactome R-HSA-110314 R-HSA-110314 Reactome Name: Recognition of DNA damage by PCNA-containing replication complex See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5651801 R-HSA-5651801 Reactome Name: PCNA-Dependent Long Patch Base Excision Repair See in Reactome R-HSA-5656169 R-HSA-5656169 Reactome Name: Termination of translesion DNA synthesis See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-110373 R-HSA-110373 Reactome Name: Resolution of AP sites via the multiple-nucleotide patch replacement pathway See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	DNA Repair DNA Replication Cell Cycle	R-HSA-110363 ( R-HSA-5651801 ) R-HSA-110363 Reaction Name: FEN1 bound to PCNA and APEX1 cleaves flap ssDNA See in Reactome R-HSA-110364 ( R-HSA-5651801 ) R-HSA-110364 Reaction Name: PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 See in Reactome R-HSA-110368 ( R-HSA-5651801 ) R-HSA-110368 Reaction Name: POLD,POLE-mediated DNA strand displacement synthesis See in Reactome R-HSA-110371 ( R-HSA-5651801 ) R-HSA-110371 Reaction Name: LIG1 binds APEX1 and PCNA at SSB See in Reactome R-HSA-5651805 ( R-HSA-5651801 ) R-HSA-5651805 Reaction Name: LIG1 bound to APEX1 and PCNA ligates SSB See in Reactome R-HSA-5651809 ( R-HSA-5651801 ) R-HSA-5651809 Reaction Name: LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA See in Reactome R-HSA-5651992 ( R-HSA-110314 ) R-HSA-5651992 Reaction Name: PCNA-containing replication complex binds damaged dsDNA See in Reactome R-HSA-5652005 ( R-HSA-110314 ) R-HSA-5652005 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA See in Reactome R-HSA-5652009 ( R-HSA-110314 ) R-HSA-5652009 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA See in Reactome R-HSA-5653838 ( R-HSA-5656169 ) R-HSA-5653838 Reaction Name: POLD,POLE binds deISGylated PCNA after TLS See in Reactome R-HSA-5653840 ( R-HSA-5656169 ) R-HSA-5653840 Reaction Name: POLD,POLE complete replication of damaged DNA after TLS See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690997 ( R-HSA-5696397 ) R-HSA-5690997 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in GG-NER See in Reactome R-HSA-5691001 ( R-HSA-5696397 ) R-HSA-5691001 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-68913 ( R-HSA-68952 ) R-HSA-68913 Reaction Name: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68960 ( R-HSA-68962 ) R-HSA-68960 Reaction Name: DNA polymerase epsilon binds at the origin See in Reactome
MONDO:0032829	POLR2A	P24928	2.7.7.48 2.7.7.6	R-HSA-6803529 R-HSA-6803529 Reactome Name: FGFR2 alternative splicing See in Reactome R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome R-HSA-203927 R-HSA-203927 Reactome Name: MicroRNA (miRNA) biogenesis See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-72203 R-HSA-72203 Reactome Name: Processing of Capped Intron-Containing Pre-mRNA See in Reactome R-HSA-73776 R-HSA-73776 Reactome Name: RNA Polymerase II Promoter Escape See in Reactome R-HSA-73779 R-HSA-73779 Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening See in Reactome R-HSA-674695 R-HSA-674695 Reactome Name: RNA Polymerase II Pre-transcription Events See in Reactome R-HSA-76042 R-HSA-76042 Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance See in Reactome R-HSA-5601884 R-HSA-5601884 Reactome Name: PIWI-interacting RNA (piRNA) biogenesis See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-72086 R-HSA-72086 Reactome Name: mRNA Capping See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-75953 R-HSA-75953 Reactome Name: RNA Polymerase II Transcription Initiation See in Reactome R-HSA-77075 R-HSA-77075 Reactome Name: RNA Pol II CTD phosphorylation and interaction with CE See in Reactome R-HSA-9670095 R-HSA-9670095 Reactome Name: Inhibition of DNA recombination at telomere See in Reactome R-HSA-72165 R-HSA-72165 Reactome Name: mRNA Splicing - Minor Pathway See in Reactome R-HSA-112382 R-HSA-112382 Reactome Name: Formation of RNA Pol II elongation complex See in Reactome R-HSA-72163 R-HSA-72163 Reactome Name: mRNA Splicing - Major Pathway See in Reactome R-HSA-6807505 R-HSA-6807505 Reactome Name: RNA polymerase II transcribes snRNA genes See in Reactome R-HSA-113418 R-HSA-113418 Reactome Name: Formation of the Early Elongation Complex See in Reactome R-HSA-5578749 R-HSA-5578749 Reactome Name: Transcriptional regulation by small RNAs See in Reactome R-HSA-75955 R-HSA-75955 Reactome Name: RNA Polymerase II Transcription Elongation See in Reactome	R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-72172 R-HSA-72172 Reactome Name: mRNA Splicing See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-157579 R-HSA-157579 Reactome Name: Telomere Maintenance See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-73886 R-HSA-73886 Reactome Name: Chromosome Maintenance See in Reactome R-HSA-211000 R-HSA-211000 Reactome Name: Gene Silencing by RNA See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of RNA DNA Repair Signal Transduction Cell Cycle Developmental Biology	R-HSA-5621002 ( R-HSA-5617472 ) R-HSA-5621002 Reaction Name: HOXB1 activates HOXB2 expression See in Reactome R-HSA-77090 ( R-HSA-72086 ) R-HSA-77090 Reaction Name: Methylation of GMP-cap by RNA Methyltransferase See in Reactome R-HSA-6803838 ( R-HSA-6803529 ) R-HSA-6803838 Reaction Name: FGFR2c-specific alternative splicing produces FGFR2c transcript See in Reactome R-HSA-109638 ( R-HSA-73779 ) R-HSA-109638 Reaction Name: Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex See in Reactome R-HSA-75866 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75866 Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP See in Reactome R-HSA-72139 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72139 Reaction Name: Formation of the active Spliceosomal C complex See in Reactome R-HSA-9012319 ( R-HSA-9018519 ) R-HSA-9012319 Reaction Name: p-TEFb phosphorylates serine 2 in RNA polymerase II CTD See in Reactome R-HSA-72095 ( R-HSA-72203 ) R-HSA-72095 Reaction Name: Internal Methylation of mRNA See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6810235 ( R-HSA-6807505 ) R-HSA-6810235 Reaction Name: RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain See in Reactome R-HSA-72107 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72107 Reaction Name: Formation of the Spliceosomal E complex See in Reactome R-HSA-113407 ( R-HSA-113418; R-HSA-75955 ) R-HSA-113407 Reaction Name: DSIF complex binds to RNA Pol II (hypophosphorylated) See in Reactome R-HSA-75095 ( R-HSA-73779 ) R-HSA-75095 Reaction Name: Binding of TFIIE to the growing preinitiation complex See in Reactome R-HSA-72124 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72124 Reaction Name: Formation of the Spliceosomal A Complex See in Reactome R-HSA-113414 ( R-HSA-674695 ) R-HSA-113414 Reaction Name: 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest See in Reactome R-HSA-75864 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75864 Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617661 ( R-HSA-5617472 ) R-HSA-5617661 Reaction Name: MAFB:JUN and EGR2 activate HOXB3 expression See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-75081 ( R-HSA-72165; R-HSA-72203 ) R-HSA-75081 Reaction Name: Formation of AT-AC B Complex See in Reactome R-HSA-203901 ( R-HSA-203927 ) R-HSA-203901 Reaction Name: Pol II mediated transcription of microRNA genes See in Reactome R-HSA-9670149 ( R-HSA-9670095 ) R-HSA-9670149 Reaction Name: TERRA transcription See in Reactome R-HSA-72130 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72130 Reaction Name: Formation of an intermediate Spliceosomal C complex See in Reactome R-HSA-6797712 ( R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome R-HSA-6781818 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781818 Reaction Name: RNA Pol II initiates transcription from damaged DNA template See in Reactome R-HSA-5617672 ( R-HSA-5617472 ) R-HSA-5617672 Reaction Name: HOXB3 gene is transcribed See in Reactome R-HSA-73946 ( R-HSA-674695 ) R-HSA-73946 Reaction Name: Abortive initiation after formation of the first phosphodiester bond See in Reactome R-HSA-77083 ( R-HSA-72086 ) R-HSA-77083 Reaction Name: Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA See in Reactome R-HSA-6810233 ( R-HSA-6807505 ) R-HSA-6810233 Reaction Name: CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter See in Reactome R-HSA-5617462 ( R-HSA-5617472 ) R-HSA-5617462 Reaction Name: HOXD1 gene is transcribed See in Reactome R-HSA-6814554 ( R-HSA-6807505 ) R-HSA-6814554 Reaction Name: Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene See in Reactome R-HSA-6803523 ( R-HSA-6803529 ) R-HSA-6803523 Reaction Name: PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA See in Reactome R-HSA-112381 ( R-HSA-112382; R-HSA-75955 ) R-HSA-112381 Reaction Name: Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex See in Reactome R-HSA-5617486 ( R-HSA-5617472 ) R-HSA-5617486 Reaction Name: HOXB2 gene is transcribed See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-9012315 ( R-HSA-9018519 ) R-HSA-9012315 Reaction Name: ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene See in Reactome R-HSA-77095 ( R-HSA-72086 ) R-HSA-77095 Reaction Name: Recognition and binding of the mRNA cap by the cap-binding complex See in Reactome R-HSA-109639 ( R-HSA-73779 ) R-HSA-109639 Reaction Name: Formation of the closed pre-initiation complex See in Reactome R-HSA-6810238 ( R-HSA-6807505 ) R-HSA-6810238 Reaction Name: RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) See in Reactome R-HSA-5578742 ( R-HSA-5578749 ) R-HSA-5578742 Reaction Name: AGO1,2:small RNA complexes interact with chromatin See in Reactome R-HSA-77085 ( R-HSA-72086 ) R-HSA-77085 Reaction Name: Dissociation of transcript with 5'-GMP from GT See in Reactome R-HSA-77073 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77073 Reaction Name: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-113430 ( R-HSA-77075 ) R-HSA-113430 Reaction Name: Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex See in Reactome R-HSA-75891 ( R-HSA-674695 ) R-HSA-75891 Reaction Name: Abortive Initiation After Second Transition See in Reactome R-HSA-6814549 ( R-HSA-6807505 ) R-HSA-6814549 Reaction Name: Pre-snRNA transcript initiation, Integrator binding, LEC binding See in Reactome R-HSA-75082 ( R-HSA-72165; R-HSA-72203 ) R-HSA-75082 Reaction Name: ATAC spliceosome mediated Lariat formation,5' splice site cleavage See in Reactome R-HSA-77068 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77068 Reaction Name: Activation of GT See in Reactome R-HSA-72160 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72160 Reaction Name: Cleavage at the 3'-Splice Site and Exon Ligation See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-77077 ( R-HSA-72086 ) R-HSA-77077 Reaction Name: Capping complex formation See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-5601926 ( R-HSA-5601884 ) R-HSA-5601926 Reaction Name: RNA polymerase II polymerizes primary piRNA transcript See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-9011971 ( R-HSA-9018519 ) R-HSA-9011971 Reaction Name: Estrogen-responsive MYB gene expression See in Reactome R-HSA-77078 ( R-HSA-72086 ) R-HSA-77078 Reaction Name: Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme See in Reactome R-HSA-5617866 ( R-HSA-5617472 ) R-HSA-5617866 Reaction Name: HOXC4 gene is transcribed See in Reactome R-HSA-5617641 ( R-HSA-5617472 ) R-HSA-5617641 Reaction Name: MAFB (KREISLER) and HOXB1:PBX1:PKNOX1 (HOXB1:PBX1:PREP1) activate HOXA3 expression See in Reactome R-HSA-9613497 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613497 Reaction Name: Unwinding DNA for the nascent transcript See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-5617492 ( R-HSA-5617472 ) R-HSA-5617492 Reaction Name: EGR2 (KROX20) activates HOXB2 expression See in Reactome R-HSA-5617484 ( R-HSA-5617472 ) R-HSA-5617484 Reaction Name: EGR2 (KROX20) activates HOXA2 expression See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-6814559 ( R-HSA-6807505 ) R-HSA-6814559 Reaction Name: Pre-snRNA is elongated and capped with 7-methylguanosine See in Reactome R-HSA-6814885 ( R-HSA-6807505 ) R-HSA-6814885 Reaction Name: CBCAP complex binds 7-methylguanosine cap of snRNA See in Reactome R-HSA-5617483 ( R-HSA-5617472 ) R-HSA-5617483 Reaction Name: HOXA2 gene is transcribed See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-77069 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77069 Reaction Name: RNA Polymerase II CTD (phosphorylated) binds to CE See in Reactome R-HSA-72127 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72127 Reaction Name: Formation of the Spliceosomal B Complex See in Reactome R-HSA-72103 ( R-HSA-72203 ) R-HSA-72103 Reaction Name: Formation of pre-mRNPs See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-113413 ( R-HSA-674695 ) R-HSA-113413 Reaction Name: TFIIS-mediated recovery of elongation from arrest See in Reactome R-HSA-75869 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75869 Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition See in Reactome R-HSA-112396 ( R-HSA-75955 ) R-HSA-112396 Reaction Name: Separation of elongating transcript from template See in Reactome R-HSA-5617445 ( R-HSA-5617472 ) R-HSA-5617445 Reaction Name: HOXD1 chromatin is activated See in Reactome R-HSA-6803836 ( R-HSA-6803529 ) R-HSA-6803836 Reaction Name: FGFR2b-specific alternative splicing produces FGFR2b transcript See in Reactome R-HSA-75079 ( R-HSA-72165; R-HSA-72203 ) R-HSA-75079 Reaction Name: Formation of AT-AC C complex See in Reactome R-HSA-113429 ( R-HSA-674695 ) R-HSA-113429 Reaction Name: Elongating transcript encounters a lesion in the template See in Reactome R-HSA-5621010 ( R-HSA-5617472 ) R-HSA-5621010 Reaction Name: HOXB1 activates HOXA2 expression See in Reactome R-HSA-113412 ( R-HSA-75955 ) R-HSA-113412 Reaction Name: Pol II elongation complex moves on the template as transcript elongates See in Reactome R-HSA-77081 ( R-HSA-72086 ) R-HSA-77081 Reaction Name: Formation of the CE:GMP intermediate complex See in Reactome R-HSA-77071 ( R-HSA-77075 ) R-HSA-77071 Reaction Name: Phosphorylation (Ser5) of RNA pol II CTD See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-112383 ( R-HSA-113418; R-HSA-75955 ) R-HSA-112383 Reaction Name: Hypophosphorylation of RNA Pol II CTD by FCP1P protein See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-75949 ( R-HSA-76042 ) R-HSA-75949 Reaction Name: RNA Polymerase II Promoter Opening: First Transition See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-75083 ( R-HSA-72165; R-HSA-72203 ) R-HSA-75083 Reaction Name: ATAC spliceosome mediated 3' splice site cleavage, exon ligation See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-5617642 ( R-HSA-5617472 ) R-HSA-5617642 Reaction Name: HOXD3 gene is transcribed See in Reactome R-HSA-6814555 ( R-HSA-6807505 ) R-HSA-6814555 Reaction Name: Integrator complex processes the 3' end of snRNA See in Reactome R-HSA-111264 ( R-HSA-73776; R-HSA-76042 ) R-HSA-111264 Reaction Name: Addition of nucleotides between position +11 and +30 See in Reactome R-HSA-5617887 ( R-HSA-5617472 ) R-HSA-5617887 Reaction Name: HOXC4 chromatin is activated See in Reactome R-HSA-112392 ( R-HSA-674695 ) R-HSA-112392 Reaction Name: Resumption of elongation after recovery from pausing See in Reactome R-HSA-6781824 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781824 Reaction Name: Active RNA Pol II complex transcribes lesion-containing DNA template See in Reactome R-HSA-6797606 ( R-HSA-6796648 ) R-HSA-6797606 Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes See in Reactome R-HSA-156661 ( R-HSA-72163; R-HSA-72203 ) R-HSA-156661 Reaction Name: Formation of Exon Junction Complex See in Reactome R-HSA-5617650 ( R-HSA-5617472 ) R-HSA-5617650 Reaction Name: HOXD3 chromatin is activated See in Reactome R-HSA-75856 ( R-HSA-674695 ) R-HSA-75856 Reaction Name: Abortive Initiation Before Second Transition See in Reactome R-HSA-113409 ( R-HSA-674695 ) R-HSA-113409 Reaction Name: Abortive termination of early transcription elongation by DSIF:NELF See in Reactome R-HSA-72143 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72143 Reaction Name: Lariat Formation and 5'-Splice Site Cleavage See in Reactome R-HSA-75080 ( R-HSA-72165; R-HSA-72203 ) R-HSA-75080 Reaction Name: Formation of AT-AC A complex See in Reactome R-HSA-75862 ( R-HSA-674695 ) R-HSA-75862 Reaction Name: Fall Back to Closed Pre-initiation Complex See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-75873 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75873 Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-112385 ( R-HSA-75955 ) R-HSA-112385 Reaction Name: Addition of nucleotides leads to transcript elongation See in Reactome R-HSA-6803527 ( R-HSA-6803529 ) R-HSA-6803527 Reaction Name: ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression See in Reactome R-HSA-5617676 ( R-HSA-5617472 ) R-HSA-5617676 Reaction Name: HOXA3 gene is transcribed See in Reactome R-HSA-75861 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75861 Reaction Name: NTP Binds Active Site of RNA Polymerase II See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-76576 ( R-HSA-73776; R-HSA-76042 ) R-HSA-76576 Reaction Name: Addition of nucleotides 10 and 11 on the growing transcript: Third Transition See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-113402 ( R-HSA-113418; R-HSA-75955 ) R-HSA-113402 Reaction Name: Formation of DSIF:NELF:early elongation complex See in Reactome R-HSA-113411 ( R-HSA-674695 ) R-HSA-113411 Reaction Name: 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing See in Reactome R-HSA-75850 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75850 Reaction Name: Addition of the third nucleotide on the nascent transcript See in Reactome R-HSA-6797616 ( R-HSA-6796648 ) R-HSA-6797616 Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-112379 ( R-HSA-112382; R-HSA-75955 ) R-HSA-112379 Reaction Name: Recruitment of elongation factors to form elongation complex See in Reactome R-HSA-112395 ( R-HSA-674695 ) R-HSA-112395 Reaction Name: Abortive termination of elongation after arrest See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-9613494 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613494 Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome

Number of enzymes:	11
Number of disease:	38
Number of reactomes:	95
Number of reactions:	345

Search summary (Reactome ID: R-HSA-6782135)

Search results (Reactome ID: R-HSA-6782135)

MONDO:0005097

R-HSA-9617629

R-HSA-210744

R-HSA-5689901

R-HSA-6804760

R-HSA-8939243

R-HSA-381340

R-HSA-9616222

R-HSA-9013695

R-HSA-6782135

R-HSA-6782210

R-HSA-8941856

R-HSA-8941858

R-HSA-6804114

R-HSA-1989781

R-HSA-9018519

R-HSA-918233

R-HSA-6781827

R-HSA-156711

R-HSA-5250924

R-HSA-6781823

R-HSA-9013508

R-HSA-3214847

R-HSA-3371568

R-HSA-8866907

R-HSA-9614657

R-HSA-9701898

R-HSA-933541

R-HSA-1234158

R-HSA-1368082

R-HSA-5617472

R-HSA-3899300

R-HSA-9029569

R-HSA-8936459

R-HSA-2122947

R-HSA-2197563

R-HSA-400253

R-HSA-9707616

R-HSA-3134973

R-HSA-201722

R-HSA-1912408

R-HSA-8951936

R-HSA-5621575

R-HSA-9031628

R-HSA-6811555

R-HSA-6804758

R-HSA-3700989

R-HSA-9012852

R-HSA-5633007

R-HSA-168256

R-HSA-9013694

R-HSA-168928

R-HSA-1640170

R-HSA-597592

R-HSA-6791312

R-HSA-1266738

R-HSA-73857

R-HSA-1430728

R-HSA-8864260

R-HSA-166520

R-HSA-212436

R-HSA-74160

R-HSA-400206

R-HSA-2262752

R-HSA-73894

R-HSA-69278

R-HSA-198725

R-HSA-2990846

R-HSA-556833

R-HSA-9024446

R-HSA-8878159

R-HSA-5621481

R-HSA-8953897

R-HSA-212165

R-HSA-5696398

R-HSA-168249

R-HSA-453274

R-HSA-392499