DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-5696400)

Number of enzymes:	6
Number of disease:	18
Number of reactomes:	40
Number of reactions:	107

Search results (Reactome ID: R-HSA-5696400)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0010212	ERCC2	P18074	3.6.4.12	R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-73776 R-HSA-73776 Reactome Name: RNA Polymerase II Promoter Escape See in Reactome R-HSA-73779 R-HSA-73779 Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening See in Reactome R-HSA-674695 R-HSA-674695 Reactome Name: RNA Polymerase II Pre-transcription Events See in Reactome R-HSA-76042 R-HSA-76042 Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance See in Reactome R-HSA-427413 R-HSA-427413 Reactome Name: NoRC negatively regulates rRNA expression See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-72086 R-HSA-72086 Reactome Name: mRNA Capping See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-77075 R-HSA-77075 Reactome Name: RNA Pol II CTD phosphorylation and interaction with CE See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome R-HSA-73863 R-HSA-73863 Reactome Name: RNA Polymerase I Transcription Termination See in Reactome R-HSA-112382 R-HSA-112382 Reactome Name: Formation of RNA Pol II elongation complex See in Reactome R-HSA-2564830 R-HSA-2564830 Reactome Name: Cytosolic iron-sulfur cluster assembly See in Reactome R-HSA-73772 R-HSA-73772 Reactome Name: RNA Polymerase I Promoter Escape See in Reactome R-HSA-113418 R-HSA-113418 Reactome Name: Formation of the Early Elongation Complex See in Reactome R-HSA-75953 R-HSA-75953 Reactome Name: RNA Polymerase II Transcription Initiation See in Reactome R-HSA-75955 R-HSA-75955 Reactome Name: RNA Polymerase II Transcription Elongation See in Reactome	R-HSA-5250941 R-HSA-5250941 Reactome Name: Negative epigenetic regulation of rRNA expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of RNA Metabolism DNA Repair	R-HSA-109639 ( R-HSA-73779 ) R-HSA-109639 Reaction Name: Formation of the closed pre-initiation complex See in Reactome R-HSA-111264 ( R-HSA-73776; R-HSA-76042 ) R-HSA-111264 Reaction Name: Addition of nucleotides between position +11 and +30 See in Reactome R-HSA-112379 ( R-HSA-112382; R-HSA-75955 ) R-HSA-112379 Reaction Name: Recruitment of elongation factors to form elongation complex See in Reactome R-HSA-112383 ( R-HSA-113418; R-HSA-75955 ) R-HSA-112383 Reaction Name: Hypophosphorylation of RNA Pol II CTD by FCP1P protein See in Reactome R-HSA-112385 ( R-HSA-75955 ) R-HSA-112385 Reaction Name: Addition of nucleotides leads to transcript elongation See in Reactome R-HSA-113430 ( R-HSA-77075 ) R-HSA-113430 Reaction Name: Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex See in Reactome R-HSA-2564828 ( R-HSA-2564830 ) R-HSA-2564828 Reaction Name: CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins See in Reactome R-HSA-427366 ( R-HSA-427413 ) R-HSA-427366 Reaction Name: Transcription of intergenic spacer of the rRNA gene See in Reactome R-HSA-5689317 ( R-HSA-5696395 ) R-HSA-5689317 Reaction Name: Formation of the pre-incision complex in GG-NER See in Reactome R-HSA-5689861 ( R-HSA-5696395 ) R-HSA-5689861 Reaction Name: Recruitment of XPA and release of CAK See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-5690996 ( R-HSA-5696395 ) R-HSA-5690996 Reaction Name: ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA See in Reactome R-HSA-5691000 ( R-HSA-5696395 ) R-HSA-5691000 Reaction Name: TFIIH binds GG-NER site to form a verification complex See in Reactome R-HSA-5696670 ( R-HSA-5696395 ) R-HSA-5696670 Reaction Name: CHD1L is recruited to GG-NER site See in Reactome R-HSA-6781818 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781818 Reaction Name: RNA Pol II initiates transcription from damaged DNA template See in Reactome R-HSA-6781824 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781824 Reaction Name: Active RNA Pol II complex transcribes lesion-containing DNA template See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-6790454 ( R-HSA-5696395 ) R-HSA-6790454 Reaction Name: SUMOylation of XPC See in Reactome R-HSA-6790487 ( R-HSA-5696395 ) R-HSA-6790487 Reaction Name: RNF111 ubiquitinates SUMOylated XPC See in Reactome R-HSA-6797606 ( R-HSA-6796648 ) R-HSA-6797606 Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes See in Reactome R-HSA-6797616 ( R-HSA-6796648 ) R-HSA-6797616 Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes See in Reactome R-HSA-6797712 ( R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome R-HSA-73758 ( R-HSA-73762 ) R-HSA-73758 Reaction Name: Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter See in Reactome R-HSA-73769 ( R-HSA-73772 ) R-HSA-73769 Reaction Name: Loss of Rrn3 from RNA Polymerase I promoter escape complex See in Reactome R-HSA-73946 ( R-HSA-674695 ) R-HSA-73946 Reaction Name: Abortive initiation after formation of the first phosphodiester bond See in Reactome R-HSA-74986 ( R-HSA-73772 ) R-HSA-74986 Reaction Name: Elongation of pre-rRNA transcript See in Reactome R-HSA-74992 ( R-HSA-73863 ) R-HSA-74992 Reaction Name: Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box See in Reactome R-HSA-74993 ( R-HSA-73863 ) R-HSA-74993 Reaction Name: PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box See in Reactome R-HSA-74994 ( R-HSA-73863 ) R-HSA-74994 Reaction Name: Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box See in Reactome R-HSA-75850 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75850 Reaction Name: Addition of the third nucleotide on the nascent transcript See in Reactome R-HSA-75856 ( R-HSA-674695 ) R-HSA-75856 Reaction Name: Abortive Initiation Before Second Transition See in Reactome R-HSA-75861 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75861 Reaction Name: NTP Binds Active Site of RNA Polymerase II See in Reactome R-HSA-75862 ( R-HSA-674695 ) R-HSA-75862 Reaction Name: Fall Back to Closed Pre-initiation Complex See in Reactome R-HSA-75864 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75864 Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released See in Reactome R-HSA-75866 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75866 Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP See in Reactome R-HSA-75869 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75869 Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition See in Reactome R-HSA-75873 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75873 Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript See in Reactome R-HSA-75891 ( R-HSA-674695 ) R-HSA-75891 Reaction Name: Abortive Initiation After Second Transition See in Reactome R-HSA-75949 ( R-HSA-76042 ) R-HSA-75949 Reaction Name: RNA Polymerase II Promoter Opening: First Transition See in Reactome R-HSA-76576 ( R-HSA-73776; R-HSA-76042 ) R-HSA-76576 Reaction Name: Addition of nucleotides 10 and 11 on the growing transcript: Third Transition See in Reactome R-HSA-77068 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77068 Reaction Name: Activation of GT See in Reactome R-HSA-77069 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77069 Reaction Name: RNA Polymerase II CTD (phosphorylated) binds to CE See in Reactome R-HSA-77071 ( R-HSA-77075 ) R-HSA-77071 Reaction Name: Phosphorylation (Ser5) of RNA pol II CTD See in Reactome R-HSA-77073 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77073 Reaction Name: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) See in Reactome R-HSA-77077 ( R-HSA-72086 ) R-HSA-77077 Reaction Name: Capping complex formation See in Reactome R-HSA-77078 ( R-HSA-72086 ) R-HSA-77078 Reaction Name: Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme See in Reactome R-HSA-77081 ( R-HSA-72086 ) R-HSA-77081 Reaction Name: Formation of the CE:GMP intermediate complex See in Reactome R-HSA-77083 ( R-HSA-72086 ) R-HSA-77083 Reaction Name: Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA See in Reactome R-HSA-77085 ( R-HSA-72086 ) R-HSA-77085 Reaction Name: Dissociation of transcript with 5'-GMP from GT See in Reactome R-HSA-77090 ( R-HSA-72086 ) R-HSA-77090 Reaction Name: Methylation of GMP-cap by RNA Methyltransferase See in Reactome R-HSA-9613494 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613494 Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition See in Reactome R-HSA-9613497 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613497 Reaction Name: Unwinding DNA for the nascent transcript See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome
MONDO:0010215	ERCC4	Q92889	3.1.-.-	R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-6783310 R-HSA-6783310 Reactome Name: Fanconi Anemia Pathway See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome	R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome	DNA Repair	R-HSA-109955 ( R-HSA-5696395 ) R-HSA-109955 Reaction Name: Formation of ERCC1:XPF heterodimeric complex See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-6782141 ( R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6785732 ( R-HSA-6783310 ) R-HSA-6785732 Reaction Name: DNA nucleases bind monoubiquitinated ID2 complex See in Reactome R-HSA-6785986 ( R-HSA-6783310 ) R-HSA-6785986 Reaction Name: DNA nucleases unhook the interstrand crosslink (ICL) See in Reactome
MONDO:0010216	ERCC5	P28715	3.1.-.-	R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome	R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome	DNA Repair	R-HSA-5689317 ( R-HSA-5696395 ) R-HSA-5689317 Reaction Name: Formation of the pre-incision complex in GG-NER See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome
MONDO:0011125	ERCC2	P18074	3.6.4.12	R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-73776 R-HSA-73776 Reactome Name: RNA Polymerase II Promoter Escape See in Reactome R-HSA-73779 R-HSA-73779 Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening See in Reactome R-HSA-674695 R-HSA-674695 Reactome Name: RNA Polymerase II Pre-transcription Events See in Reactome R-HSA-76042 R-HSA-76042 Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance See in Reactome R-HSA-427413 R-HSA-427413 Reactome Name: NoRC negatively regulates rRNA expression See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-72086 R-HSA-72086 Reactome Name: mRNA Capping See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-77075 R-HSA-77075 Reactome Name: RNA Pol II CTD phosphorylation and interaction with CE See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome R-HSA-73863 R-HSA-73863 Reactome Name: RNA Polymerase I Transcription Termination See in Reactome R-HSA-112382 R-HSA-112382 Reactome Name: Formation of RNA Pol II elongation complex See in Reactome R-HSA-2564830 R-HSA-2564830 Reactome Name: Cytosolic iron-sulfur cluster assembly See in Reactome R-HSA-73772 R-HSA-73772 Reactome Name: RNA Polymerase I Promoter Escape See in Reactome R-HSA-113418 R-HSA-113418 Reactome Name: Formation of the Early Elongation Complex See in Reactome R-HSA-75953 R-HSA-75953 Reactome Name: RNA Polymerase II Transcription Initiation See in Reactome R-HSA-75955 R-HSA-75955 Reactome Name: RNA Polymerase II Transcription Elongation See in Reactome	R-HSA-5250941 R-HSA-5250941 Reactome Name: Negative epigenetic regulation of rRNA expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of RNA Metabolism DNA Repair	R-HSA-109639 ( R-HSA-73779 ) R-HSA-109639 Reaction Name: Formation of the closed pre-initiation complex See in Reactome R-HSA-111264 ( R-HSA-73776; R-HSA-76042 ) R-HSA-111264 Reaction Name: Addition of nucleotides between position +11 and +30 See in Reactome R-HSA-112379 ( R-HSA-112382; R-HSA-75955 ) R-HSA-112379 Reaction Name: Recruitment of elongation factors to form elongation complex See in Reactome R-HSA-112383 ( R-HSA-113418; R-HSA-75955 ) R-HSA-112383 Reaction Name: Hypophosphorylation of RNA Pol II CTD by FCP1P protein See in Reactome R-HSA-112385 ( R-HSA-75955 ) R-HSA-112385 Reaction Name: Addition of nucleotides leads to transcript elongation See in Reactome R-HSA-113430 ( R-HSA-77075 ) R-HSA-113430 Reaction Name: Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex See in Reactome R-HSA-2564828 ( R-HSA-2564830 ) R-HSA-2564828 Reaction Name: CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins See in Reactome R-HSA-427366 ( R-HSA-427413 ) R-HSA-427366 Reaction Name: Transcription of intergenic spacer of the rRNA gene See in Reactome R-HSA-5689317 ( R-HSA-5696395 ) R-HSA-5689317 Reaction Name: Formation of the pre-incision complex in GG-NER See in Reactome R-HSA-5689861 ( R-HSA-5696395 ) R-HSA-5689861 Reaction Name: Recruitment of XPA and release of CAK See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-5690996 ( R-HSA-5696395 ) R-HSA-5690996 Reaction Name: ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA See in Reactome R-HSA-5691000 ( R-HSA-5696395 ) R-HSA-5691000 Reaction Name: TFIIH binds GG-NER site to form a verification complex See in Reactome R-HSA-5696670 ( R-HSA-5696395 ) R-HSA-5696670 Reaction Name: CHD1L is recruited to GG-NER site See in Reactome R-HSA-6781818 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781818 Reaction Name: RNA Pol II initiates transcription from damaged DNA template See in Reactome R-HSA-6781824 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781824 Reaction Name: Active RNA Pol II complex transcribes lesion-containing DNA template See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-6790454 ( R-HSA-5696395 ) R-HSA-6790454 Reaction Name: SUMOylation of XPC See in Reactome R-HSA-6790487 ( R-HSA-5696395 ) R-HSA-6790487 Reaction Name: RNF111 ubiquitinates SUMOylated XPC See in Reactome R-HSA-6797606 ( R-HSA-6796648 ) R-HSA-6797606 Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes See in Reactome R-HSA-6797616 ( R-HSA-6796648 ) R-HSA-6797616 Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes See in Reactome R-HSA-6797712 ( R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome R-HSA-73758 ( R-HSA-73762 ) R-HSA-73758 Reaction Name: Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter See in Reactome R-HSA-73769 ( R-HSA-73772 ) R-HSA-73769 Reaction Name: Loss of Rrn3 from RNA Polymerase I promoter escape complex See in Reactome R-HSA-73946 ( R-HSA-674695 ) R-HSA-73946 Reaction Name: Abortive initiation after formation of the first phosphodiester bond See in Reactome R-HSA-74986 ( R-HSA-73772 ) R-HSA-74986 Reaction Name: Elongation of pre-rRNA transcript See in Reactome R-HSA-74992 ( R-HSA-73863 ) R-HSA-74992 Reaction Name: Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box See in Reactome R-HSA-74993 ( R-HSA-73863 ) R-HSA-74993 Reaction Name: PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box See in Reactome R-HSA-74994 ( R-HSA-73863 ) R-HSA-74994 Reaction Name: Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box See in Reactome R-HSA-75850 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75850 Reaction Name: Addition of the third nucleotide on the nascent transcript See in Reactome R-HSA-75856 ( R-HSA-674695 ) R-HSA-75856 Reaction Name: Abortive Initiation Before Second Transition See in Reactome R-HSA-75861 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75861 Reaction Name: NTP Binds Active Site of RNA Polymerase II See in Reactome R-HSA-75862 ( R-HSA-674695 ) R-HSA-75862 Reaction Name: Fall Back to Closed Pre-initiation Complex See in Reactome R-HSA-75864 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75864 Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released See in Reactome R-HSA-75866 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75866 Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP See in Reactome R-HSA-75869 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75869 Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition See in Reactome R-HSA-75873 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75873 Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript See in Reactome R-HSA-75891 ( R-HSA-674695 ) R-HSA-75891 Reaction Name: Abortive Initiation After Second Transition See in Reactome R-HSA-75949 ( R-HSA-76042 ) R-HSA-75949 Reaction Name: RNA Polymerase II Promoter Opening: First Transition See in Reactome R-HSA-76576 ( R-HSA-73776; R-HSA-76042 ) R-HSA-76576 Reaction Name: Addition of nucleotides 10 and 11 on the growing transcript: Third Transition See in Reactome R-HSA-77068 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77068 Reaction Name: Activation of GT See in Reactome R-HSA-77069 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77069 Reaction Name: RNA Polymerase II CTD (phosphorylated) binds to CE See in Reactome R-HSA-77071 ( R-HSA-77075 ) R-HSA-77071 Reaction Name: Phosphorylation (Ser5) of RNA pol II CTD See in Reactome R-HSA-77073 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77073 Reaction Name: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) See in Reactome R-HSA-77077 ( R-HSA-72086 ) R-HSA-77077 Reaction Name: Capping complex formation See in Reactome R-HSA-77078 ( R-HSA-72086 ) R-HSA-77078 Reaction Name: Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme See in Reactome R-HSA-77081 ( R-HSA-72086 ) R-HSA-77081 Reaction Name: Formation of the CE:GMP intermediate complex See in Reactome R-HSA-77083 ( R-HSA-72086 ) R-HSA-77083 Reaction Name: Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA See in Reactome R-HSA-77085 ( R-HSA-72086 ) R-HSA-77085 Reaction Name: Dissociation of transcript with 5'-GMP from GT See in Reactome R-HSA-77090 ( R-HSA-72086 ) R-HSA-77090 Reaction Name: Methylation of GMP-cap by RNA Methyltransferase See in Reactome R-HSA-9613494 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613494 Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition See in Reactome R-HSA-9613497 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613497 Reaction Name: Unwinding DNA for the nascent transcript See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome
MONDO:0012531	ERCC3	P19447	3.6.4.12	R-HSA-75955 R-HSA-75955 Reactome Name: RNA Polymerase II Transcription Elongation See in Reactome R-HSA-112382 R-HSA-112382 Reactome Name: Formation of RNA Pol II elongation complex See in Reactome R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-427413 R-HSA-427413 Reactome Name: NoRC negatively regulates rRNA expression See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-75953 R-HSA-75953 Reactome Name: RNA Polymerase II Transcription Initiation See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome R-HSA-73863 R-HSA-73863 Reactome Name: RNA Polymerase I Transcription Termination See in Reactome R-HSA-73776 R-HSA-73776 Reactome Name: RNA Polymerase II Promoter Escape See in Reactome R-HSA-73779 R-HSA-73779 Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening See in Reactome R-HSA-76042 R-HSA-76042 Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance See in Reactome R-HSA-77075 R-HSA-77075 Reactome Name: RNA Pol II CTD phosphorylation and interaction with CE See in Reactome R-HSA-73772 R-HSA-73772 Reactome Name: RNA Polymerase I Promoter Escape See in Reactome R-HSA-72086 R-HSA-72086 Reactome Name: mRNA Capping See in Reactome R-HSA-113418 R-HSA-113418 Reactome Name: Formation of the Early Elongation Complex See in Reactome R-HSA-674695 R-HSA-674695 Reactome Name: RNA Polymerase II Pre-transcription Events See in Reactome	R-HSA-5250941 R-HSA-5250941 Reactome Name: Negative epigenetic regulation of rRNA expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of RNA DNA Repair	R-HSA-109639 ( R-HSA-73779 ) R-HSA-109639 Reaction Name: Formation of the closed pre-initiation complex See in Reactome R-HSA-111264 ( R-HSA-73776; R-HSA-76042 ) R-HSA-111264 Reaction Name: Addition of nucleotides between position +11 and +30 See in Reactome R-HSA-112379 ( R-HSA-112382; R-HSA-75955 ) R-HSA-112379 Reaction Name: Recruitment of elongation factors to form elongation complex See in Reactome R-HSA-112383 ( R-HSA-113418; R-HSA-75955 ) R-HSA-112383 Reaction Name: Hypophosphorylation of RNA Pol II CTD by FCP1P protein See in Reactome R-HSA-112385 ( R-HSA-75955 ) R-HSA-112385 Reaction Name: Addition of nucleotides leads to transcript elongation See in Reactome R-HSA-113430 ( R-HSA-77075 ) R-HSA-113430 Reaction Name: Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex See in Reactome R-HSA-427366 ( R-HSA-427413 ) R-HSA-427366 Reaction Name: Transcription of intergenic spacer of the rRNA gene See in Reactome R-HSA-5689317 ( R-HSA-5696395 ) R-HSA-5689317 Reaction Name: Formation of the pre-incision complex in GG-NER See in Reactome R-HSA-5689861 ( R-HSA-5696395 ) R-HSA-5689861 Reaction Name: Recruitment of XPA and release of CAK See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-5690996 ( R-HSA-5696395 ) R-HSA-5690996 Reaction Name: ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA See in Reactome R-HSA-5691000 ( R-HSA-5696395 ) R-HSA-5691000 Reaction Name: TFIIH binds GG-NER site to form a verification complex See in Reactome R-HSA-5696670 ( R-HSA-5696395 ) R-HSA-5696670 Reaction Name: CHD1L is recruited to GG-NER site See in Reactome R-HSA-6781818 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781818 Reaction Name: RNA Pol II initiates transcription from damaged DNA template See in Reactome R-HSA-6781824 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781824 Reaction Name: Active RNA Pol II complex transcribes lesion-containing DNA template See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-6790454 ( R-HSA-5696395 ) R-HSA-6790454 Reaction Name: SUMOylation of XPC See in Reactome R-HSA-6790487 ( R-HSA-5696395 ) R-HSA-6790487 Reaction Name: RNF111 ubiquitinates SUMOylated XPC See in Reactome R-HSA-6797606 ( R-HSA-6796648 ) R-HSA-6797606 Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes See in Reactome R-HSA-6797616 ( R-HSA-6796648 ) R-HSA-6797616 Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes See in Reactome R-HSA-6797712 ( R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome R-HSA-73758 ( R-HSA-73762 ) R-HSA-73758 Reaction Name: Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter See in Reactome R-HSA-73769 ( R-HSA-73772 ) R-HSA-73769 Reaction Name: Loss of Rrn3 from RNA Polymerase I promoter escape complex See in Reactome R-HSA-73946 ( R-HSA-674695 ) R-HSA-73946 Reaction Name: Abortive initiation after formation of the first phosphodiester bond See in Reactome R-HSA-74986 ( R-HSA-73772 ) R-HSA-74986 Reaction Name: Elongation of pre-rRNA transcript See in Reactome R-HSA-74992 ( R-HSA-73863 ) R-HSA-74992 Reaction Name: Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box See in Reactome R-HSA-74993 ( R-HSA-73863 ) R-HSA-74993 Reaction Name: PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box See in Reactome R-HSA-74994 ( R-HSA-73863 ) R-HSA-74994 Reaction Name: Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box See in Reactome R-HSA-75850 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75850 Reaction Name: Addition of the third nucleotide on the nascent transcript See in Reactome R-HSA-75856 ( R-HSA-674695 ) R-HSA-75856 Reaction Name: Abortive Initiation Before Second Transition See in Reactome R-HSA-75861 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75861 Reaction Name: NTP Binds Active Site of RNA Polymerase II See in Reactome R-HSA-75862 ( R-HSA-674695 ) R-HSA-75862 Reaction Name: Fall Back to Closed Pre-initiation Complex See in Reactome R-HSA-75864 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75864 Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released See in Reactome R-HSA-75866 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75866 Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP See in Reactome R-HSA-75869 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75869 Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition See in Reactome R-HSA-75873 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75873 Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript See in Reactome R-HSA-75891 ( R-HSA-674695 ) R-HSA-75891 Reaction Name: Abortive Initiation After Second Transition See in Reactome R-HSA-75949 ( R-HSA-76042 ) R-HSA-75949 Reaction Name: RNA Polymerase II Promoter Opening: First Transition See in Reactome R-HSA-76576 ( R-HSA-73776; R-HSA-76042 ) R-HSA-76576 Reaction Name: Addition of nucleotides 10 and 11 on the growing transcript: Third Transition See in Reactome R-HSA-77068 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77068 Reaction Name: Activation of GT See in Reactome R-HSA-77069 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77069 Reaction Name: RNA Polymerase II CTD (phosphorylated) binds to CE See in Reactome R-HSA-77071 ( R-HSA-77075 ) R-HSA-77071 Reaction Name: Phosphorylation (Ser5) of RNA pol II CTD See in Reactome R-HSA-77073 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77073 Reaction Name: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) See in Reactome R-HSA-77077 ( R-HSA-72086 ) R-HSA-77077 Reaction Name: Capping complex formation See in Reactome R-HSA-77078 ( R-HSA-72086 ) R-HSA-77078 Reaction Name: Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme See in Reactome R-HSA-77081 ( R-HSA-72086 ) R-HSA-77081 Reaction Name: Formation of the CE:GMP intermediate complex See in Reactome R-HSA-77083 ( R-HSA-72086 ) R-HSA-77083 Reaction Name: Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA See in Reactome R-HSA-77085 ( R-HSA-72086 ) R-HSA-77085 Reaction Name: Dissociation of transcript with 5'-GMP from GT See in Reactome R-HSA-77090 ( R-HSA-72086 ) R-HSA-77090 Reaction Name: Methylation of GMP-cap by RNA Methyltransferase See in Reactome R-HSA-9613494 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613494 Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition See in Reactome R-HSA-9613497 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613497 Reaction Name: Unwinding DNA for the nascent transcript See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome
MONDO:0012553	ERCC2	P18074	3.6.4.12	R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-73776 R-HSA-73776 Reactome Name: RNA Polymerase II Promoter Escape See in Reactome R-HSA-73779 R-HSA-73779 Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening See in Reactome R-HSA-674695 R-HSA-674695 Reactome Name: RNA Polymerase II Pre-transcription Events See in Reactome R-HSA-76042 R-HSA-76042 Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance See in Reactome R-HSA-427413 R-HSA-427413 Reactome Name: NoRC negatively regulates rRNA expression See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-72086 R-HSA-72086 Reactome Name: mRNA Capping See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-77075 R-HSA-77075 Reactome Name: RNA Pol II CTD phosphorylation and interaction with CE See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome R-HSA-73863 R-HSA-73863 Reactome Name: RNA Polymerase I Transcription Termination See in Reactome R-HSA-112382 R-HSA-112382 Reactome Name: Formation of RNA Pol II elongation complex See in Reactome R-HSA-2564830 R-HSA-2564830 Reactome Name: Cytosolic iron-sulfur cluster assembly See in Reactome R-HSA-73772 R-HSA-73772 Reactome Name: RNA Polymerase I Promoter Escape See in Reactome R-HSA-113418 R-HSA-113418 Reactome Name: Formation of the Early Elongation Complex See in Reactome R-HSA-75953 R-HSA-75953 Reactome Name: RNA Polymerase II Transcription Initiation See in Reactome R-HSA-75955 R-HSA-75955 Reactome Name: RNA Polymerase II Transcription Elongation See in Reactome	R-HSA-5250941 R-HSA-5250941 Reactome Name: Negative epigenetic regulation of rRNA expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of RNA Metabolism DNA Repair	R-HSA-109639 ( R-HSA-73779 ) R-HSA-109639 Reaction Name: Formation of the closed pre-initiation complex See in Reactome R-HSA-111264 ( R-HSA-73776; R-HSA-76042 ) R-HSA-111264 Reaction Name: Addition of nucleotides between position +11 and +30 See in Reactome R-HSA-112379 ( R-HSA-112382; R-HSA-75955 ) R-HSA-112379 Reaction Name: Recruitment of elongation factors to form elongation complex See in Reactome R-HSA-112383 ( R-HSA-113418; R-HSA-75955 ) R-HSA-112383 Reaction Name: Hypophosphorylation of RNA Pol II CTD by FCP1P protein See in Reactome R-HSA-112385 ( R-HSA-75955 ) R-HSA-112385 Reaction Name: Addition of nucleotides leads to transcript elongation See in Reactome R-HSA-113430 ( R-HSA-77075 ) R-HSA-113430 Reaction Name: Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex See in Reactome R-HSA-2564828 ( R-HSA-2564830 ) R-HSA-2564828 Reaction Name: CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins See in Reactome R-HSA-427366 ( R-HSA-427413 ) R-HSA-427366 Reaction Name: Transcription of intergenic spacer of the rRNA gene See in Reactome R-HSA-5689317 ( R-HSA-5696395 ) R-HSA-5689317 Reaction Name: Formation of the pre-incision complex in GG-NER See in Reactome R-HSA-5689861 ( R-HSA-5696395 ) R-HSA-5689861 Reaction Name: Recruitment of XPA and release of CAK See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-5690996 ( R-HSA-5696395 ) R-HSA-5690996 Reaction Name: ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA See in Reactome R-HSA-5691000 ( R-HSA-5696395 ) R-HSA-5691000 Reaction Name: TFIIH binds GG-NER site to form a verification complex See in Reactome R-HSA-5696670 ( R-HSA-5696395 ) R-HSA-5696670 Reaction Name: CHD1L is recruited to GG-NER site See in Reactome R-HSA-6781818 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781818 Reaction Name: RNA Pol II initiates transcription from damaged DNA template See in Reactome R-HSA-6781824 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781824 Reaction Name: Active RNA Pol II complex transcribes lesion-containing DNA template See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-6790454 ( R-HSA-5696395 ) R-HSA-6790454 Reaction Name: SUMOylation of XPC See in Reactome R-HSA-6790487 ( R-HSA-5696395 ) R-HSA-6790487 Reaction Name: RNF111 ubiquitinates SUMOylated XPC See in Reactome R-HSA-6797606 ( R-HSA-6796648 ) R-HSA-6797606 Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes See in Reactome R-HSA-6797616 ( R-HSA-6796648 ) R-HSA-6797616 Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes See in Reactome R-HSA-6797712 ( R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome R-HSA-73758 ( R-HSA-73762 ) R-HSA-73758 Reaction Name: Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter See in Reactome R-HSA-73769 ( R-HSA-73772 ) R-HSA-73769 Reaction Name: Loss of Rrn3 from RNA Polymerase I promoter escape complex See in Reactome R-HSA-73946 ( R-HSA-674695 ) R-HSA-73946 Reaction Name: Abortive initiation after formation of the first phosphodiester bond See in Reactome R-HSA-74986 ( R-HSA-73772 ) R-HSA-74986 Reaction Name: Elongation of pre-rRNA transcript See in Reactome R-HSA-74992 ( R-HSA-73863 ) R-HSA-74992 Reaction Name: Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box See in Reactome R-HSA-74993 ( R-HSA-73863 ) R-HSA-74993 Reaction Name: PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box See in Reactome R-HSA-74994 ( R-HSA-73863 ) R-HSA-74994 Reaction Name: Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box See in Reactome R-HSA-75850 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75850 Reaction Name: Addition of the third nucleotide on the nascent transcript See in Reactome R-HSA-75856 ( R-HSA-674695 ) R-HSA-75856 Reaction Name: Abortive Initiation Before Second Transition See in Reactome R-HSA-75861 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75861 Reaction Name: NTP Binds Active Site of RNA Polymerase II See in Reactome R-HSA-75862 ( R-HSA-674695 ) R-HSA-75862 Reaction Name: Fall Back to Closed Pre-initiation Complex See in Reactome R-HSA-75864 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75864 Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released See in Reactome R-HSA-75866 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75866 Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP See in Reactome R-HSA-75869 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75869 Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition See in Reactome R-HSA-75873 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75873 Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript See in Reactome R-HSA-75891 ( R-HSA-674695 ) R-HSA-75891 Reaction Name: Abortive Initiation After Second Transition See in Reactome R-HSA-75949 ( R-HSA-76042 ) R-HSA-75949 Reaction Name: RNA Polymerase II Promoter Opening: First Transition See in Reactome R-HSA-76576 ( R-HSA-73776; R-HSA-76042 ) R-HSA-76576 Reaction Name: Addition of nucleotides 10 and 11 on the growing transcript: Third Transition See in Reactome R-HSA-77068 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77068 Reaction Name: Activation of GT See in Reactome R-HSA-77069 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77069 Reaction Name: RNA Polymerase II CTD (phosphorylated) binds to CE See in Reactome R-HSA-77071 ( R-HSA-77075 ) R-HSA-77071 Reaction Name: Phosphorylation (Ser5) of RNA pol II CTD See in Reactome R-HSA-77073 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77073 Reaction Name: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) See in Reactome R-HSA-77077 ( R-HSA-72086 ) R-HSA-77077 Reaction Name: Capping complex formation See in Reactome R-HSA-77078 ( R-HSA-72086 ) R-HSA-77078 Reaction Name: Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme See in Reactome R-HSA-77081 ( R-HSA-72086 ) R-HSA-77081 Reaction Name: Formation of the CE:GMP intermediate complex See in Reactome R-HSA-77083 ( R-HSA-72086 ) R-HSA-77083 Reaction Name: Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA See in Reactome R-HSA-77085 ( R-HSA-72086 ) R-HSA-77085 Reaction Name: Dissociation of transcript with 5'-GMP from GT See in Reactome R-HSA-77090 ( R-HSA-72086 ) R-HSA-77090 Reaction Name: Methylation of GMP-cap by RNA Methyltransferase See in Reactome R-HSA-9613494 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613494 Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition See in Reactome R-HSA-9613497 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613497 Reaction Name: Unwinding DNA for the nascent transcript See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome
MONDO:0012590	ERCC4	Q92889	3.1.-.-	R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-6783310 R-HSA-6783310 Reactome Name: Fanconi Anemia Pathway See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome	R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome	DNA Repair	R-HSA-109955 ( R-HSA-5696395 ) R-HSA-109955 Reaction Name: Formation of ERCC1:XPF heterodimeric complex See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-6782141 ( R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6785732 ( R-HSA-6783310 ) R-HSA-6785732 Reaction Name: DNA nucleases bind monoubiquitinated ID2 complex See in Reactome R-HSA-6785986 ( R-HSA-6783310 ) R-HSA-6785986 Reaction Name: DNA nucleases unhook the interstrand crosslink (ICL) See in Reactome
MONDO:0012953	POLD1	P28340	3.1.11.- 2.7.7.7	R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5358606 R-HSA-5358606 Reactome Name: Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) See in Reactome R-HSA-5696397 R-HSA-5696397 Reactome Name: Gap-filling DNA repair synthesis and ligation in GG-NER See in Reactome R-HSA-69091 R-HSA-69091 Reactome Name: Polymerase switching See in Reactome R-HSA-110314 R-HSA-110314 Reactome Name: Recognition of DNA damage by PCNA-containing replication complex See in Reactome R-HSA-174414 R-HSA-174414 Reactome Name: Processive synthesis on the C-strand of the telomere See in Reactome R-HSA-174417 R-HSA-174417 Reactome Name: Telomere C-strand (Lagging Strand) Synthesis See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-174411 R-HSA-174411 Reactome Name: Polymerase switching on the C-strand of the telomere See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-174437 R-HSA-174437 Reactome Name: Removal of the Flap Intermediate from the C-strand See in Reactome R-HSA-5358565 R-HSA-5358565 Reactome Name: Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) See in Reactome R-HSA-5651801 R-HSA-5651801 Reactome Name: PCNA-Dependent Long Patch Base Excision Repair See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-2564830 R-HSA-2564830 Reactome Name: Cytosolic iron-sulfur cluster assembly See in Reactome R-HSA-69166 R-HSA-69166 Reactome Name: Removal of the Flap Intermediate See in Reactome R-HSA-5656169 R-HSA-5656169 Reactome Name: Termination of translesion DNA synthesis See in Reactome R-HSA-69183 R-HSA-69183 Reactome Name: Processive synthesis on the lagging strand See in Reactome	R-HSA-69109 R-HSA-69109 Reactome Name: Leading Strand Synthesis See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-69190 R-HSA-69190 Reactome Name: DNA strand elongation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-73886 R-HSA-73886 Reactome Name: Chromosome Maintenance See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-110373 R-HSA-110373 Reactome Name: Resolution of AP sites via the multiple-nucleotide patch replacement pathway See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-157579 R-HSA-157579 Reactome Name: Telomere Maintenance See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-5358508 R-HSA-5358508 Reactome Name: Mismatch Repair See in Reactome R-HSA-180786 R-HSA-180786 Reactome Name: Extension of Telomeres See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-69186 R-HSA-69186 Reactome Name: Lagging Strand Synthesis See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	Cell Cycle DNA Replication DNA Repair Metabolism	R-HSA-110363 ( R-HSA-5651801 ) R-HSA-110363 Reaction Name: FEN1 bound to PCNA and APEX1 cleaves flap ssDNA See in Reactome R-HSA-110364 ( R-HSA-5651801 ) R-HSA-110364 Reaction Name: PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 See in Reactome R-HSA-110368 ( R-HSA-5651801 ) R-HSA-110368 Reaction Name: POLD,POLE-mediated DNA strand displacement synthesis See in Reactome R-HSA-110371 ( R-HSA-5651801 ) R-HSA-110371 Reaction Name: LIG1 binds APEX1 and PCNA at SSB See in Reactome R-HSA-174438 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174438 Reaction Name: Formation of the Flap Intermediate on the C-strand See in Reactome R-HSA-174441 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174441 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand See in Reactome R-HSA-174444 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174444 Reaction Name: Formation of C-strand Okazaki fragments See in Reactome R-HSA-174445 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174445 Reaction Name: RPA binds to the Flap on the C-strand See in Reactome R-HSA-174446 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174446 Reaction Name: Removal of remaining Flap from the C-strand See in Reactome R-HSA-174448 ( R-HSA-174411; R-HSA-174417 ) R-HSA-174448 Reaction Name: Formation of Processive Complex on the C-strand of the telomere See in Reactome R-HSA-174451 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174451 Reaction Name: Recruitment of DNA2 endonuclease to the C strand See in Reactome R-HSA-174456 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174456 Reaction Name: Joining of adjacent Okazaki fragments of the C-strand See in Reactome R-HSA-176702 ( R-HSA-174417 ) R-HSA-176702 Reaction Name: Disassociation of Processive Complex and Completed Telomere End See in Reactome R-HSA-2564828 ( R-HSA-2564830 ) R-HSA-2564828 Reaction Name: CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins See in Reactome R-HSA-5358579 ( R-HSA-5358565; R-HSA-5358606 ) R-HSA-5358579 Reaction Name: DNA polymerase delta polymerizes DNA across single stranded gap See in Reactome R-HSA-5651805 ( R-HSA-5651801 ) R-HSA-5651805 Reaction Name: LIG1 bound to APEX1 and PCNA ligates SSB See in Reactome R-HSA-5651809 ( R-HSA-5651801 ) R-HSA-5651809 Reaction Name: LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA See in Reactome R-HSA-5651992 ( R-HSA-110314 ) R-HSA-5651992 Reaction Name: PCNA-containing replication complex binds damaged dsDNA See in Reactome R-HSA-5652005 ( R-HSA-110314 ) R-HSA-5652005 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA See in Reactome R-HSA-5652009 ( R-HSA-110314 ) R-HSA-5652009 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA See in Reactome R-HSA-5653838 ( R-HSA-5656169 ) R-HSA-5653838 Reaction Name: POLD,POLE binds deISGylated PCNA after TLS See in Reactome R-HSA-5653840 ( R-HSA-5656169 ) R-HSA-5653840 Reaction Name: POLD,POLE complete replication of damaged DNA after TLS See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690997 ( R-HSA-5696397 ) R-HSA-5690997 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in GG-NER See in Reactome R-HSA-5691001 ( R-HSA-5696397 ) R-HSA-5691001 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-69074 ( R-HSA-69091 ) R-HSA-69074 Reaction Name: Formation of Processive Complex See in Reactome R-HSA-69116 ( R-HSA-69183 ) R-HSA-69116 Reaction Name: Formation of Okazaki fragments See in Reactome R-HSA-69127 ( R-HSA-69183 ) R-HSA-69127 Reaction Name: Formation of the Flap Intermediate See in Reactome R-HSA-69140 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69140 Reaction Name: RPA binds to the Flap See in Reactome R-HSA-69142 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69142 Reaction Name: Recruitment of Dna2 endonuclease See in Reactome R-HSA-69144 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69144 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 See in Reactome R-HSA-69152 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69152 Reaction Name: Removal of remaining Flap See in Reactome
MONDO:0013873	POLE	Q07864	3.1.11.- 2.7.7.7	R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-5696397 R-HSA-5696397 Reactome Name: Gap-filling DNA repair synthesis and ligation in GG-NER See in Reactome R-HSA-68952 R-HSA-68952 Reactome Name: DNA replication initiation See in Reactome R-HSA-110314 R-HSA-110314 Reactome Name: Recognition of DNA damage by PCNA-containing replication complex See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5651801 R-HSA-5651801 Reactome Name: PCNA-Dependent Long Patch Base Excision Repair See in Reactome R-HSA-5656169 R-HSA-5656169 Reactome Name: Termination of translesion DNA synthesis See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-110373 R-HSA-110373 Reactome Name: Resolution of AP sites via the multiple-nucleotide patch replacement pathway See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	DNA Repair DNA Replication Cell Cycle	R-HSA-110363 ( R-HSA-5651801 ) R-HSA-110363 Reaction Name: FEN1 bound to PCNA and APEX1 cleaves flap ssDNA See in Reactome R-HSA-110364 ( R-HSA-5651801 ) R-HSA-110364 Reaction Name: PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 See in Reactome R-HSA-110368 ( R-HSA-5651801 ) R-HSA-110368 Reaction Name: POLD,POLE-mediated DNA strand displacement synthesis See in Reactome R-HSA-110371 ( R-HSA-5651801 ) R-HSA-110371 Reaction Name: LIG1 binds APEX1 and PCNA at SSB See in Reactome R-HSA-5651805 ( R-HSA-5651801 ) R-HSA-5651805 Reaction Name: LIG1 bound to APEX1 and PCNA ligates SSB See in Reactome R-HSA-5651809 ( R-HSA-5651801 ) R-HSA-5651809 Reaction Name: LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA See in Reactome R-HSA-5651992 ( R-HSA-110314 ) R-HSA-5651992 Reaction Name: PCNA-containing replication complex binds damaged dsDNA See in Reactome R-HSA-5652005 ( R-HSA-110314 ) R-HSA-5652005 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA See in Reactome R-HSA-5652009 ( R-HSA-110314 ) R-HSA-5652009 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA See in Reactome R-HSA-5653838 ( R-HSA-5656169 ) R-HSA-5653838 Reaction Name: POLD,POLE binds deISGylated PCNA after TLS See in Reactome R-HSA-5653840 ( R-HSA-5656169 ) R-HSA-5653840 Reaction Name: POLD,POLE complete replication of damaged DNA after TLS See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690997 ( R-HSA-5696397 ) R-HSA-5690997 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in GG-NER See in Reactome R-HSA-5691001 ( R-HSA-5696397 ) R-HSA-5691001 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-68913 ( R-HSA-68952 ) R-HSA-68913 Reaction Name: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68960 ( R-HSA-68962 ) R-HSA-68960 Reaction Name: DNA polymerase epsilon binds at the origin See in Reactome
MONDO:0014038	POLE	Q07864	3.1.11.- 2.7.7.7	R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-5696397 R-HSA-5696397 Reactome Name: Gap-filling DNA repair synthesis and ligation in GG-NER See in Reactome R-HSA-68952 R-HSA-68952 Reactome Name: DNA replication initiation See in Reactome R-HSA-110314 R-HSA-110314 Reactome Name: Recognition of DNA damage by PCNA-containing replication complex See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5651801 R-HSA-5651801 Reactome Name: PCNA-Dependent Long Patch Base Excision Repair See in Reactome R-HSA-5656169 R-HSA-5656169 Reactome Name: Termination of translesion DNA synthesis See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-110373 R-HSA-110373 Reactome Name: Resolution of AP sites via the multiple-nucleotide patch replacement pathway See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	DNA Repair DNA Replication Cell Cycle	R-HSA-110363 ( R-HSA-5651801 ) R-HSA-110363 Reaction Name: FEN1 bound to PCNA and APEX1 cleaves flap ssDNA See in Reactome R-HSA-110364 ( R-HSA-5651801 ) R-HSA-110364 Reaction Name: PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 See in Reactome R-HSA-110368 ( R-HSA-5651801 ) R-HSA-110368 Reaction Name: POLD,POLE-mediated DNA strand displacement synthesis See in Reactome R-HSA-110371 ( R-HSA-5651801 ) R-HSA-110371 Reaction Name: LIG1 binds APEX1 and PCNA at SSB See in Reactome R-HSA-5651805 ( R-HSA-5651801 ) R-HSA-5651805 Reaction Name: LIG1 bound to APEX1 and PCNA ligates SSB See in Reactome R-HSA-5651809 ( R-HSA-5651801 ) R-HSA-5651809 Reaction Name: LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA See in Reactome R-HSA-5651992 ( R-HSA-110314 ) R-HSA-5651992 Reaction Name: PCNA-containing replication complex binds damaged dsDNA See in Reactome R-HSA-5652005 ( R-HSA-110314 ) R-HSA-5652005 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA See in Reactome R-HSA-5652009 ( R-HSA-110314 ) R-HSA-5652009 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA See in Reactome R-HSA-5653838 ( R-HSA-5656169 ) R-HSA-5653838 Reaction Name: POLD,POLE binds deISGylated PCNA after TLS See in Reactome R-HSA-5653840 ( R-HSA-5656169 ) R-HSA-5653840 Reaction Name: POLD,POLE complete replication of damaged DNA after TLS See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690997 ( R-HSA-5696397 ) R-HSA-5690997 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in GG-NER See in Reactome R-HSA-5691001 ( R-HSA-5696397 ) R-HSA-5691001 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-68913 ( R-HSA-68952 ) R-HSA-68913 Reaction Name: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68960 ( R-HSA-68962 ) R-HSA-68960 Reaction Name: DNA polymerase epsilon binds at the origin See in Reactome
MONDO:0014058	POLE	Q07864	3.1.11.- 2.7.7.7	R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-5696397 R-HSA-5696397 Reactome Name: Gap-filling DNA repair synthesis and ligation in GG-NER See in Reactome R-HSA-68952 R-HSA-68952 Reactome Name: DNA replication initiation See in Reactome R-HSA-110314 R-HSA-110314 Reactome Name: Recognition of DNA damage by PCNA-containing replication complex See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5651801 R-HSA-5651801 Reactome Name: PCNA-Dependent Long Patch Base Excision Repair See in Reactome R-HSA-5656169 R-HSA-5656169 Reactome Name: Termination of translesion DNA synthesis See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-110373 R-HSA-110373 Reactome Name: Resolution of AP sites via the multiple-nucleotide patch replacement pathway See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	DNA Repair DNA Replication Cell Cycle	R-HSA-110363 ( R-HSA-5651801 ) R-HSA-110363 Reaction Name: FEN1 bound to PCNA and APEX1 cleaves flap ssDNA See in Reactome R-HSA-110364 ( R-HSA-5651801 ) R-HSA-110364 Reaction Name: PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 See in Reactome R-HSA-110368 ( R-HSA-5651801 ) R-HSA-110368 Reaction Name: POLD,POLE-mediated DNA strand displacement synthesis See in Reactome R-HSA-110371 ( R-HSA-5651801 ) R-HSA-110371 Reaction Name: LIG1 binds APEX1 and PCNA at SSB See in Reactome R-HSA-5651805 ( R-HSA-5651801 ) R-HSA-5651805 Reaction Name: LIG1 bound to APEX1 and PCNA ligates SSB See in Reactome R-HSA-5651809 ( R-HSA-5651801 ) R-HSA-5651809 Reaction Name: LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA See in Reactome R-HSA-5651992 ( R-HSA-110314 ) R-HSA-5651992 Reaction Name: PCNA-containing replication complex binds damaged dsDNA See in Reactome R-HSA-5652005 ( R-HSA-110314 ) R-HSA-5652005 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA See in Reactome R-HSA-5652009 ( R-HSA-110314 ) R-HSA-5652009 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA See in Reactome R-HSA-5653838 ( R-HSA-5656169 ) R-HSA-5653838 Reaction Name: POLD,POLE binds deISGylated PCNA after TLS See in Reactome R-HSA-5653840 ( R-HSA-5656169 ) R-HSA-5653840 Reaction Name: POLD,POLE complete replication of damaged DNA after TLS See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690997 ( R-HSA-5696397 ) R-HSA-5690997 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in GG-NER See in Reactome R-HSA-5691001 ( R-HSA-5696397 ) R-HSA-5691001 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-68913 ( R-HSA-68952 ) R-HSA-68913 Reaction Name: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68960 ( R-HSA-68962 ) R-HSA-68960 Reaction Name: DNA polymerase epsilon binds at the origin See in Reactome
MONDO:0014108	ERCC4	Q92889	3.1.-.-	R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-6783310 R-HSA-6783310 Reactome Name: Fanconi Anemia Pathway See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome	R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome	DNA Repair	R-HSA-109955 ( R-HSA-5696395 ) R-HSA-109955 Reaction Name: Formation of ERCC1:XPF heterodimeric complex See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-6782141 ( R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6785732 ( R-HSA-6783310 ) R-HSA-6785732 Reaction Name: DNA nucleases bind monoubiquitinated ID2 complex See in Reactome R-HSA-6785986 ( R-HSA-6783310 ) R-HSA-6785986 Reaction Name: DNA nucleases unhook the interstrand crosslink (ICL) See in Reactome
MONDO:0014157	POLD1	P28340	3.1.11.- 2.7.7.7	R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5358606 R-HSA-5358606 Reactome Name: Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) See in Reactome R-HSA-5696397 R-HSA-5696397 Reactome Name: Gap-filling DNA repair synthesis and ligation in GG-NER See in Reactome R-HSA-69091 R-HSA-69091 Reactome Name: Polymerase switching See in Reactome R-HSA-110314 R-HSA-110314 Reactome Name: Recognition of DNA damage by PCNA-containing replication complex See in Reactome R-HSA-174414 R-HSA-174414 Reactome Name: Processive synthesis on the C-strand of the telomere See in Reactome R-HSA-174417 R-HSA-174417 Reactome Name: Telomere C-strand (Lagging Strand) Synthesis See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-174411 R-HSA-174411 Reactome Name: Polymerase switching on the C-strand of the telomere See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-174437 R-HSA-174437 Reactome Name: Removal of the Flap Intermediate from the C-strand See in Reactome R-HSA-5358565 R-HSA-5358565 Reactome Name: Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) See in Reactome R-HSA-5651801 R-HSA-5651801 Reactome Name: PCNA-Dependent Long Patch Base Excision Repair See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-2564830 R-HSA-2564830 Reactome Name: Cytosolic iron-sulfur cluster assembly See in Reactome R-HSA-69166 R-HSA-69166 Reactome Name: Removal of the Flap Intermediate See in Reactome R-HSA-5656169 R-HSA-5656169 Reactome Name: Termination of translesion DNA synthesis See in Reactome R-HSA-69183 R-HSA-69183 Reactome Name: Processive synthesis on the lagging strand See in Reactome	R-HSA-69109 R-HSA-69109 Reactome Name: Leading Strand Synthesis See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-69190 R-HSA-69190 Reactome Name: DNA strand elongation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-73886 R-HSA-73886 Reactome Name: Chromosome Maintenance See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-110373 R-HSA-110373 Reactome Name: Resolution of AP sites via the multiple-nucleotide patch replacement pathway See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-157579 R-HSA-157579 Reactome Name: Telomere Maintenance See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-5358508 R-HSA-5358508 Reactome Name: Mismatch Repair See in Reactome R-HSA-180786 R-HSA-180786 Reactome Name: Extension of Telomeres See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-69186 R-HSA-69186 Reactome Name: Lagging Strand Synthesis See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	Cell Cycle DNA Replication DNA Repair Metabolism	R-HSA-110363 ( R-HSA-5651801 ) R-HSA-110363 Reaction Name: FEN1 bound to PCNA and APEX1 cleaves flap ssDNA See in Reactome R-HSA-110364 ( R-HSA-5651801 ) R-HSA-110364 Reaction Name: PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 See in Reactome R-HSA-110368 ( R-HSA-5651801 ) R-HSA-110368 Reaction Name: POLD,POLE-mediated DNA strand displacement synthesis See in Reactome R-HSA-110371 ( R-HSA-5651801 ) R-HSA-110371 Reaction Name: LIG1 binds APEX1 and PCNA at SSB See in Reactome R-HSA-174438 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174438 Reaction Name: Formation of the Flap Intermediate on the C-strand See in Reactome R-HSA-174441 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174441 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand See in Reactome R-HSA-174444 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174444 Reaction Name: Formation of C-strand Okazaki fragments See in Reactome R-HSA-174445 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174445 Reaction Name: RPA binds to the Flap on the C-strand See in Reactome R-HSA-174446 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174446 Reaction Name: Removal of remaining Flap from the C-strand See in Reactome R-HSA-174448 ( R-HSA-174411; R-HSA-174417 ) R-HSA-174448 Reaction Name: Formation of Processive Complex on the C-strand of the telomere See in Reactome R-HSA-174451 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174451 Reaction Name: Recruitment of DNA2 endonuclease to the C strand See in Reactome R-HSA-174456 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174456 Reaction Name: Joining of adjacent Okazaki fragments of the C-strand See in Reactome R-HSA-176702 ( R-HSA-174417 ) R-HSA-176702 Reaction Name: Disassociation of Processive Complex and Completed Telomere End See in Reactome R-HSA-2564828 ( R-HSA-2564830 ) R-HSA-2564828 Reaction Name: CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins See in Reactome R-HSA-5358579 ( R-HSA-5358565; R-HSA-5358606 ) R-HSA-5358579 Reaction Name: DNA polymerase delta polymerizes DNA across single stranded gap See in Reactome R-HSA-5651805 ( R-HSA-5651801 ) R-HSA-5651805 Reaction Name: LIG1 bound to APEX1 and PCNA ligates SSB See in Reactome R-HSA-5651809 ( R-HSA-5651801 ) R-HSA-5651809 Reaction Name: LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA See in Reactome R-HSA-5651992 ( R-HSA-110314 ) R-HSA-5651992 Reaction Name: PCNA-containing replication complex binds damaged dsDNA See in Reactome R-HSA-5652005 ( R-HSA-110314 ) R-HSA-5652005 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA See in Reactome R-HSA-5652009 ( R-HSA-110314 ) R-HSA-5652009 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA See in Reactome R-HSA-5653838 ( R-HSA-5656169 ) R-HSA-5653838 Reaction Name: POLD,POLE binds deISGylated PCNA after TLS See in Reactome R-HSA-5653840 ( R-HSA-5656169 ) R-HSA-5653840 Reaction Name: POLD,POLE complete replication of damaged DNA after TLS See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690997 ( R-HSA-5696397 ) R-HSA-5690997 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in GG-NER See in Reactome R-HSA-5691001 ( R-HSA-5696397 ) R-HSA-5691001 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-69074 ( R-HSA-69091 ) R-HSA-69074 Reaction Name: Formation of Processive Complex See in Reactome R-HSA-69116 ( R-HSA-69183 ) R-HSA-69116 Reaction Name: Formation of Okazaki fragments See in Reactome R-HSA-69127 ( R-HSA-69183 ) R-HSA-69127 Reaction Name: Formation of the Flap Intermediate See in Reactome R-HSA-69140 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69140 Reaction Name: RPA binds to the Flap See in Reactome R-HSA-69142 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69142 Reaction Name: Recruitment of Dna2 endonuclease See in Reactome R-HSA-69144 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69144 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 See in Reactome R-HSA-69152 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69152 Reaction Name: Removal of remaining Flap See in Reactome
MONDO:0014615	ERCC3	P19447	3.6.4.12	R-HSA-75955 R-HSA-75955 Reactome Name: RNA Polymerase II Transcription Elongation See in Reactome R-HSA-112382 R-HSA-112382 Reactome Name: Formation of RNA Pol II elongation complex See in Reactome R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-427413 R-HSA-427413 Reactome Name: NoRC negatively regulates rRNA expression See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-75953 R-HSA-75953 Reactome Name: RNA Polymerase II Transcription Initiation See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome R-HSA-73863 R-HSA-73863 Reactome Name: RNA Polymerase I Transcription Termination See in Reactome R-HSA-73776 R-HSA-73776 Reactome Name: RNA Polymerase II Promoter Escape See in Reactome R-HSA-73779 R-HSA-73779 Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening See in Reactome R-HSA-76042 R-HSA-76042 Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance See in Reactome R-HSA-77075 R-HSA-77075 Reactome Name: RNA Pol II CTD phosphorylation and interaction with CE See in Reactome R-HSA-73772 R-HSA-73772 Reactome Name: RNA Polymerase I Promoter Escape See in Reactome R-HSA-72086 R-HSA-72086 Reactome Name: mRNA Capping See in Reactome R-HSA-113418 R-HSA-113418 Reactome Name: Formation of the Early Elongation Complex See in Reactome R-HSA-674695 R-HSA-674695 Reactome Name: RNA Polymerase II Pre-transcription Events See in Reactome	R-HSA-5250941 R-HSA-5250941 Reactome Name: Negative epigenetic regulation of rRNA expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of RNA DNA Repair	R-HSA-109639 ( R-HSA-73779 ) R-HSA-109639 Reaction Name: Formation of the closed pre-initiation complex See in Reactome R-HSA-111264 ( R-HSA-73776; R-HSA-76042 ) R-HSA-111264 Reaction Name: Addition of nucleotides between position +11 and +30 See in Reactome R-HSA-112379 ( R-HSA-112382; R-HSA-75955 ) R-HSA-112379 Reaction Name: Recruitment of elongation factors to form elongation complex See in Reactome R-HSA-112383 ( R-HSA-113418; R-HSA-75955 ) R-HSA-112383 Reaction Name: Hypophosphorylation of RNA Pol II CTD by FCP1P protein See in Reactome R-HSA-112385 ( R-HSA-75955 ) R-HSA-112385 Reaction Name: Addition of nucleotides leads to transcript elongation See in Reactome R-HSA-113430 ( R-HSA-77075 ) R-HSA-113430 Reaction Name: Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex See in Reactome R-HSA-427366 ( R-HSA-427413 ) R-HSA-427366 Reaction Name: Transcription of intergenic spacer of the rRNA gene See in Reactome R-HSA-5689317 ( R-HSA-5696395 ) R-HSA-5689317 Reaction Name: Formation of the pre-incision complex in GG-NER See in Reactome R-HSA-5689861 ( R-HSA-5696395 ) R-HSA-5689861 Reaction Name: Recruitment of XPA and release of CAK See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-5690996 ( R-HSA-5696395 ) R-HSA-5690996 Reaction Name: ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA See in Reactome R-HSA-5691000 ( R-HSA-5696395 ) R-HSA-5691000 Reaction Name: TFIIH binds GG-NER site to form a verification complex See in Reactome R-HSA-5696670 ( R-HSA-5696395 ) R-HSA-5696670 Reaction Name: CHD1L is recruited to GG-NER site See in Reactome R-HSA-6781818 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781818 Reaction Name: RNA Pol II initiates transcription from damaged DNA template See in Reactome R-HSA-6781824 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781824 Reaction Name: Active RNA Pol II complex transcribes lesion-containing DNA template See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-6790454 ( R-HSA-5696395 ) R-HSA-6790454 Reaction Name: SUMOylation of XPC See in Reactome R-HSA-6790487 ( R-HSA-5696395 ) R-HSA-6790487 Reaction Name: RNF111 ubiquitinates SUMOylated XPC See in Reactome R-HSA-6797606 ( R-HSA-6796648 ) R-HSA-6797606 Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes See in Reactome R-HSA-6797616 ( R-HSA-6796648 ) R-HSA-6797616 Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes See in Reactome R-HSA-6797712 ( R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome R-HSA-73758 ( R-HSA-73762 ) R-HSA-73758 Reaction Name: Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter See in Reactome R-HSA-73769 ( R-HSA-73772 ) R-HSA-73769 Reaction Name: Loss of Rrn3 from RNA Polymerase I promoter escape complex See in Reactome R-HSA-73946 ( R-HSA-674695 ) R-HSA-73946 Reaction Name: Abortive initiation after formation of the first phosphodiester bond See in Reactome R-HSA-74986 ( R-HSA-73772 ) R-HSA-74986 Reaction Name: Elongation of pre-rRNA transcript See in Reactome R-HSA-74992 ( R-HSA-73863 ) R-HSA-74992 Reaction Name: Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box See in Reactome R-HSA-74993 ( R-HSA-73863 ) R-HSA-74993 Reaction Name: PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box See in Reactome R-HSA-74994 ( R-HSA-73863 ) R-HSA-74994 Reaction Name: Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box See in Reactome R-HSA-75850 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75850 Reaction Name: Addition of the third nucleotide on the nascent transcript See in Reactome R-HSA-75856 ( R-HSA-674695 ) R-HSA-75856 Reaction Name: Abortive Initiation Before Second Transition See in Reactome R-HSA-75861 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75861 Reaction Name: NTP Binds Active Site of RNA Polymerase II See in Reactome R-HSA-75862 ( R-HSA-674695 ) R-HSA-75862 Reaction Name: Fall Back to Closed Pre-initiation Complex See in Reactome R-HSA-75864 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75864 Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released See in Reactome R-HSA-75866 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75866 Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP See in Reactome R-HSA-75869 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75869 Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition See in Reactome R-HSA-75873 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75873 Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript See in Reactome R-HSA-75891 ( R-HSA-674695 ) R-HSA-75891 Reaction Name: Abortive Initiation After Second Transition See in Reactome R-HSA-75949 ( R-HSA-76042 ) R-HSA-75949 Reaction Name: RNA Polymerase II Promoter Opening: First Transition See in Reactome R-HSA-76576 ( R-HSA-73776; R-HSA-76042 ) R-HSA-76576 Reaction Name: Addition of nucleotides 10 and 11 on the growing transcript: Third Transition See in Reactome R-HSA-77068 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77068 Reaction Name: Activation of GT See in Reactome R-HSA-77069 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77069 Reaction Name: RNA Polymerase II CTD (phosphorylated) binds to CE See in Reactome R-HSA-77071 ( R-HSA-77075 ) R-HSA-77071 Reaction Name: Phosphorylation (Ser5) of RNA pol II CTD See in Reactome R-HSA-77073 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77073 Reaction Name: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) See in Reactome R-HSA-77077 ( R-HSA-72086 ) R-HSA-77077 Reaction Name: Capping complex formation See in Reactome R-HSA-77078 ( R-HSA-72086 ) R-HSA-77078 Reaction Name: Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme See in Reactome R-HSA-77081 ( R-HSA-72086 ) R-HSA-77081 Reaction Name: Formation of the CE:GMP intermediate complex See in Reactome R-HSA-77083 ( R-HSA-72086 ) R-HSA-77083 Reaction Name: Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA See in Reactome R-HSA-77085 ( R-HSA-72086 ) R-HSA-77085 Reaction Name: Dissociation of transcript with 5'-GMP from GT See in Reactome R-HSA-77090 ( R-HSA-72086 ) R-HSA-77090 Reaction Name: Methylation of GMP-cap by RNA Methyltransferase See in Reactome R-HSA-9613494 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613494 Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition See in Reactome R-HSA-9613497 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613497 Reaction Name: Unwinding DNA for the nascent transcript See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome
MONDO:0014696	ERCC5	P28715	3.1.-.-	R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome	R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome	DNA Repair	R-HSA-5689317 ( R-HSA-5696395 ) R-HSA-5689317 Reaction Name: Formation of the pre-incision complex in GG-NER See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome
MONDO:0018653	POLD1	P28340	3.1.11.- 2.7.7.7	R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5358606 R-HSA-5358606 Reactome Name: Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) See in Reactome R-HSA-5696397 R-HSA-5696397 Reactome Name: Gap-filling DNA repair synthesis and ligation in GG-NER See in Reactome R-HSA-69091 R-HSA-69091 Reactome Name: Polymerase switching See in Reactome R-HSA-110314 R-HSA-110314 Reactome Name: Recognition of DNA damage by PCNA-containing replication complex See in Reactome R-HSA-174414 R-HSA-174414 Reactome Name: Processive synthesis on the C-strand of the telomere See in Reactome R-HSA-174417 R-HSA-174417 Reactome Name: Telomere C-strand (Lagging Strand) Synthesis See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-174411 R-HSA-174411 Reactome Name: Polymerase switching on the C-strand of the telomere See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-174437 R-HSA-174437 Reactome Name: Removal of the Flap Intermediate from the C-strand See in Reactome R-HSA-5358565 R-HSA-5358565 Reactome Name: Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) See in Reactome R-HSA-5651801 R-HSA-5651801 Reactome Name: PCNA-Dependent Long Patch Base Excision Repair See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-2564830 R-HSA-2564830 Reactome Name: Cytosolic iron-sulfur cluster assembly See in Reactome R-HSA-69166 R-HSA-69166 Reactome Name: Removal of the Flap Intermediate See in Reactome R-HSA-5656169 R-HSA-5656169 Reactome Name: Termination of translesion DNA synthesis See in Reactome R-HSA-69183 R-HSA-69183 Reactome Name: Processive synthesis on the lagging strand See in Reactome	R-HSA-69109 R-HSA-69109 Reactome Name: Leading Strand Synthesis See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-69190 R-HSA-69190 Reactome Name: DNA strand elongation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-73886 R-HSA-73886 Reactome Name: Chromosome Maintenance See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-110373 R-HSA-110373 Reactome Name: Resolution of AP sites via the multiple-nucleotide patch replacement pathway See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-157579 R-HSA-157579 Reactome Name: Telomere Maintenance See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-5358508 R-HSA-5358508 Reactome Name: Mismatch Repair See in Reactome R-HSA-180786 R-HSA-180786 Reactome Name: Extension of Telomeres See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-69186 R-HSA-69186 Reactome Name: Lagging Strand Synthesis See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	Cell Cycle DNA Replication DNA Repair Metabolism	R-HSA-110363 ( R-HSA-5651801 ) R-HSA-110363 Reaction Name: FEN1 bound to PCNA and APEX1 cleaves flap ssDNA See in Reactome R-HSA-110364 ( R-HSA-5651801 ) R-HSA-110364 Reaction Name: PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 See in Reactome R-HSA-110368 ( R-HSA-5651801 ) R-HSA-110368 Reaction Name: POLD,POLE-mediated DNA strand displacement synthesis See in Reactome R-HSA-110371 ( R-HSA-5651801 ) R-HSA-110371 Reaction Name: LIG1 binds APEX1 and PCNA at SSB See in Reactome R-HSA-174438 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174438 Reaction Name: Formation of the Flap Intermediate on the C-strand See in Reactome R-HSA-174441 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174441 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand See in Reactome R-HSA-174444 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174444 Reaction Name: Formation of C-strand Okazaki fragments See in Reactome R-HSA-174445 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174445 Reaction Name: RPA binds to the Flap on the C-strand See in Reactome R-HSA-174446 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174446 Reaction Name: Removal of remaining Flap from the C-strand See in Reactome R-HSA-174448 ( R-HSA-174411; R-HSA-174417 ) R-HSA-174448 Reaction Name: Formation of Processive Complex on the C-strand of the telomere See in Reactome R-HSA-174451 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174451 Reaction Name: Recruitment of DNA2 endonuclease to the C strand See in Reactome R-HSA-174456 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174456 Reaction Name: Joining of adjacent Okazaki fragments of the C-strand See in Reactome R-HSA-176702 ( R-HSA-174417 ) R-HSA-176702 Reaction Name: Disassociation of Processive Complex and Completed Telomere End See in Reactome R-HSA-2564828 ( R-HSA-2564830 ) R-HSA-2564828 Reaction Name: CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins See in Reactome R-HSA-5358579 ( R-HSA-5358565; R-HSA-5358606 ) R-HSA-5358579 Reaction Name: DNA polymerase delta polymerizes DNA across single stranded gap See in Reactome R-HSA-5651805 ( R-HSA-5651801 ) R-HSA-5651805 Reaction Name: LIG1 bound to APEX1 and PCNA ligates SSB See in Reactome R-HSA-5651809 ( R-HSA-5651801 ) R-HSA-5651809 Reaction Name: LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA See in Reactome R-HSA-5651992 ( R-HSA-110314 ) R-HSA-5651992 Reaction Name: PCNA-containing replication complex binds damaged dsDNA See in Reactome R-HSA-5652005 ( R-HSA-110314 ) R-HSA-5652005 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA See in Reactome R-HSA-5652009 ( R-HSA-110314 ) R-HSA-5652009 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA See in Reactome R-HSA-5653838 ( R-HSA-5656169 ) R-HSA-5653838 Reaction Name: POLD,POLE binds deISGylated PCNA after TLS See in Reactome R-HSA-5653840 ( R-HSA-5656169 ) R-HSA-5653840 Reaction Name: POLD,POLE complete replication of damaged DNA after TLS See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690997 ( R-HSA-5696397 ) R-HSA-5690997 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in GG-NER See in Reactome R-HSA-5691001 ( R-HSA-5696397 ) R-HSA-5691001 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-69074 ( R-HSA-69091 ) R-HSA-69074 Reaction Name: Formation of Processive Complex See in Reactome R-HSA-69116 ( R-HSA-69183 ) R-HSA-69116 Reaction Name: Formation of Okazaki fragments See in Reactome R-HSA-69127 ( R-HSA-69183 ) R-HSA-69127 Reaction Name: Formation of the Flap Intermediate See in Reactome R-HSA-69140 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69140 Reaction Name: RPA binds to the Flap See in Reactome R-HSA-69142 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69142 Reaction Name: Recruitment of Dna2 endonuclease See in Reactome R-HSA-69144 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69144 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 See in Reactome R-HSA-69152 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69152 Reaction Name: Removal of remaining Flap See in Reactome
MONDO:0018653	POLE	Q07864	3.1.11.- 2.7.7.7	R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-5696397 R-HSA-5696397 Reactome Name: Gap-filling DNA repair synthesis and ligation in GG-NER See in Reactome R-HSA-68952 R-HSA-68952 Reactome Name: DNA replication initiation See in Reactome R-HSA-110314 R-HSA-110314 Reactome Name: Recognition of DNA damage by PCNA-containing replication complex See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5651801 R-HSA-5651801 Reactome Name: PCNA-Dependent Long Patch Base Excision Repair See in Reactome R-HSA-5656169 R-HSA-5656169 Reactome Name: Termination of translesion DNA synthesis See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-110373 R-HSA-110373 Reactome Name: Resolution of AP sites via the multiple-nucleotide patch replacement pathway See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	DNA Repair DNA Replication Cell Cycle	R-HSA-110363 ( R-HSA-5651801 ) R-HSA-110363 Reaction Name: FEN1 bound to PCNA and APEX1 cleaves flap ssDNA See in Reactome R-HSA-110364 ( R-HSA-5651801 ) R-HSA-110364 Reaction Name: PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 See in Reactome R-HSA-110368 ( R-HSA-5651801 ) R-HSA-110368 Reaction Name: POLD,POLE-mediated DNA strand displacement synthesis See in Reactome R-HSA-110371 ( R-HSA-5651801 ) R-HSA-110371 Reaction Name: LIG1 binds APEX1 and PCNA at SSB See in Reactome R-HSA-5651805 ( R-HSA-5651801 ) R-HSA-5651805 Reaction Name: LIG1 bound to APEX1 and PCNA ligates SSB See in Reactome R-HSA-5651809 ( R-HSA-5651801 ) R-HSA-5651809 Reaction Name: LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA See in Reactome R-HSA-5651992 ( R-HSA-110314 ) R-HSA-5651992 Reaction Name: PCNA-containing replication complex binds damaged dsDNA See in Reactome R-HSA-5652005 ( R-HSA-110314 ) R-HSA-5652005 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA See in Reactome R-HSA-5652009 ( R-HSA-110314 ) R-HSA-5652009 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA See in Reactome R-HSA-5653838 ( R-HSA-5656169 ) R-HSA-5653838 Reaction Name: POLD,POLE binds deISGylated PCNA after TLS See in Reactome R-HSA-5653840 ( R-HSA-5656169 ) R-HSA-5653840 Reaction Name: POLD,POLE complete replication of damaged DNA after TLS See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690997 ( R-HSA-5696397 ) R-HSA-5690997 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in GG-NER See in Reactome R-HSA-5691001 ( R-HSA-5696397 ) R-HSA-5691001 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-68913 ( R-HSA-68952 ) R-HSA-68913 Reaction Name: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68960 ( R-HSA-68962 ) R-HSA-68960 Reaction Name: DNA polymerase epsilon binds at the origin See in Reactome
MONDO:0019569	ERCC4	Q92889	3.1.-.-	R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-6783310 R-HSA-6783310 Reactome Name: Fanconi Anemia Pathway See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome	R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome	DNA Repair	R-HSA-109955 ( R-HSA-5696395 ) R-HSA-109955 Reaction Name: Formation of ERCC1:XPF heterodimeric complex See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-6782141 ( R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6785732 ( R-HSA-6783310 ) R-HSA-6785732 Reaction Name: DNA nucleases bind monoubiquitinated ID2 complex See in Reactome R-HSA-6785986 ( R-HSA-6783310 ) R-HSA-6785986 Reaction Name: DNA nucleases unhook the interstrand crosslink (ICL) See in Reactome
MONDO:0032684	POLE	Q07864	3.1.11.- 2.7.7.7	R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-5696397 R-HSA-5696397 Reactome Name: Gap-filling DNA repair synthesis and ligation in GG-NER See in Reactome R-HSA-68952 R-HSA-68952 Reactome Name: DNA replication initiation See in Reactome R-HSA-110314 R-HSA-110314 Reactome Name: Recognition of DNA damage by PCNA-containing replication complex See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5651801 R-HSA-5651801 Reactome Name: PCNA-Dependent Long Patch Base Excision Repair See in Reactome R-HSA-5656169 R-HSA-5656169 Reactome Name: Termination of translesion DNA synthesis See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-110373 R-HSA-110373 Reactome Name: Resolution of AP sites via the multiple-nucleotide patch replacement pathway See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	DNA Repair DNA Replication Cell Cycle	R-HSA-110363 ( R-HSA-5651801 ) R-HSA-110363 Reaction Name: FEN1 bound to PCNA and APEX1 cleaves flap ssDNA See in Reactome R-HSA-110364 ( R-HSA-5651801 ) R-HSA-110364 Reaction Name: PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 See in Reactome R-HSA-110368 ( R-HSA-5651801 ) R-HSA-110368 Reaction Name: POLD,POLE-mediated DNA strand displacement synthesis See in Reactome R-HSA-110371 ( R-HSA-5651801 ) R-HSA-110371 Reaction Name: LIG1 binds APEX1 and PCNA at SSB See in Reactome R-HSA-5651805 ( R-HSA-5651801 ) R-HSA-5651805 Reaction Name: LIG1 bound to APEX1 and PCNA ligates SSB See in Reactome R-HSA-5651809 ( R-HSA-5651801 ) R-HSA-5651809 Reaction Name: LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA See in Reactome R-HSA-5651992 ( R-HSA-110314 ) R-HSA-5651992 Reaction Name: PCNA-containing replication complex binds damaged dsDNA See in Reactome R-HSA-5652005 ( R-HSA-110314 ) R-HSA-5652005 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA See in Reactome R-HSA-5652009 ( R-HSA-110314 ) R-HSA-5652009 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA See in Reactome R-HSA-5653838 ( R-HSA-5656169 ) R-HSA-5653838 Reaction Name: POLD,POLE binds deISGylated PCNA after TLS See in Reactome R-HSA-5653840 ( R-HSA-5656169 ) R-HSA-5653840 Reaction Name: POLD,POLE complete replication of damaged DNA after TLS See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690997 ( R-HSA-5696397 ) R-HSA-5690997 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in GG-NER See in Reactome R-HSA-5691001 ( R-HSA-5696397 ) R-HSA-5691001 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-68913 ( R-HSA-68952 ) R-HSA-68913 Reaction Name: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68960 ( R-HSA-68962 ) R-HSA-68960 Reaction Name: DNA polymerase epsilon binds at the origin See in Reactome