MONDO:0010212 |
ERCC2 |
P18074 |
3.6.4.12
|
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-6782135
R-HSA-6782210
R-HSA-6782210
Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER
See in Reactome
R-HSA-73776
R-HSA-73776
Reactome Name: RNA Polymerase II Promoter Escape
See in Reactome
R-HSA-73779
R-HSA-73779
Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
See in Reactome
R-HSA-674695
R-HSA-674695
Reactome Name: RNA Polymerase II Pre-transcription Events
See in Reactome
R-HSA-76042
R-HSA-76042
Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance
See in Reactome
R-HSA-427413
R-HSA-427413
Reactome Name: NoRC negatively regulates rRNA expression
See in Reactome
R-HSA-6781827
R-HSA-6781827
Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER)
See in Reactome
R-HSA-6781823
R-HSA-6781823
Reactome Name: Formation of TC-NER Pre-Incision Complex
See in Reactome
R-HSA-5696395
R-HSA-5696395
Reactome Name: Formation of Incision Complex in GG-NER
See in Reactome
R-HSA-72086
R-HSA-5696400
R-HSA-77075
R-HSA-77075
Reactome Name: RNA Pol II CTD phosphorylation and interaction with CE
See in Reactome
R-HSA-73762
R-HSA-73762
Reactome Name: RNA Polymerase I Transcription Initiation
See in Reactome
R-HSA-73863
R-HSA-73863
Reactome Name: RNA Polymerase I Transcription Termination
See in Reactome
R-HSA-112382
R-HSA-112382
Reactome Name: Formation of RNA Pol II elongation complex
See in Reactome
R-HSA-2564830
R-HSA-2564830
Reactome Name: Cytosolic iron-sulfur cluster assembly
See in Reactome
R-HSA-73772
R-HSA-73772
Reactome Name: RNA Polymerase I Promoter Escape
See in Reactome
R-HSA-113418
R-HSA-113418
Reactome Name: Formation of the Early Elongation Complex
See in Reactome
R-HSA-75953
R-HSA-75953
Reactome Name: RNA Polymerase II Transcription Initiation
See in Reactome
R-HSA-75955
R-HSA-75955
Reactome Name: RNA Polymerase II Transcription Elongation
See in Reactome
|
R-HSA-5250941
R-HSA-5250941
Reactome Name: Negative epigenetic regulation of rRNA expression
See in Reactome
R-HSA-5696398
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-5696399
R-HSA-5696399
Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER)
See in Reactome
R-HSA-8953854
R-HSA-1430728
R-HSA-212165
R-HSA-212165
Reactome Name: Epigenetic regulation of gene expression
See in Reactome
R-HSA-73894
R-HSA-73864
R-HSA-73854
R-HSA-73854
Reactome Name: RNA Polymerase I Promoter Clearance
See in Reactome
R-HSA-73857
|
Gene expression (Transcription)
Metabolism of RNA
Metabolism
DNA Repair
|
R-HSA-109639
(
R-HSA-73779
)
R-HSA-109639
Reaction Name: Formation of the closed pre-initiation complex
See in Reactome
R-HSA-111264
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-111264
Reaction Name: Addition of nucleotides between position +11 and +30
See in Reactome
R-HSA-112379
(
R-HSA-112382;
R-HSA-75955
)
R-HSA-112379
Reaction Name: Recruitment of elongation factors to form elongation complex
See in Reactome
R-HSA-112383
(
R-HSA-113418;
R-HSA-75955
)
R-HSA-112383
Reaction Name: Hypophosphorylation of RNA Pol II CTD by FCP1P protein
See in Reactome
R-HSA-112385
(
R-HSA-75955
)
R-HSA-112385
Reaction Name: Addition of nucleotides leads to transcript elongation
See in Reactome
R-HSA-113430
(
R-HSA-77075
)
R-HSA-113430
Reaction Name: Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex
See in Reactome
R-HSA-2564828
(
R-HSA-2564830
)
R-HSA-2564828
Reaction Name: CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins
See in Reactome
R-HSA-427366
(
R-HSA-427413
)
R-HSA-427366
Reaction Name: Transcription of intergenic spacer of the rRNA gene
See in Reactome
R-HSA-5689317
(
R-HSA-5696395
)
R-HSA-5689317
Reaction Name: Formation of the pre-incision complex in GG-NER
See in Reactome
R-HSA-5689861
(
R-HSA-5696395
)
R-HSA-5689861
Reaction Name: Recruitment of XPA and release of CAK
See in Reactome
R-HSA-5690213
(
R-HSA-5696400
)
R-HSA-5690213
Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site
See in Reactome
R-HSA-5690988
(
R-HSA-5696400
)
R-HSA-5690988
Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER
See in Reactome
R-HSA-5690990
(
R-HSA-5696400
)
R-HSA-5690990
Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER
See in Reactome
R-HSA-5690991
(
R-HSA-5696395
)
R-HSA-5690991
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER
See in Reactome
R-HSA-5690996
(
R-HSA-5696395
)
R-HSA-5690996
Reaction Name: ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA
See in Reactome
R-HSA-5691000
(
R-HSA-5696395
)
R-HSA-5691000
Reaction Name: TFIIH binds GG-NER site to form a verification complex
See in Reactome
R-HSA-5696670
(
R-HSA-5696395
)
R-HSA-5696670
Reaction Name: CHD1L is recruited to GG-NER site
See in Reactome
R-HSA-6781818
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781818
Reaction Name: RNA Pol II initiates transcription from damaged DNA template
See in Reactome
R-HSA-6781824
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781824
Reaction Name: Active RNA Pol II complex transcribes lesion-containing DNA template
See in Reactome
R-HSA-6781833
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781833
Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II
See in Reactome
R-HSA-6781840
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781840
Reaction Name: ERCC6 binds stalled RNA Pol II
See in Reactome
R-HSA-6781867
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781867
Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II
See in Reactome
R-HSA-6782004
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6782004
Reaction Name: Assembly of the pre-incision complex in TC-NER
See in Reactome
R-HSA-6782069
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6782069
Reaction Name: UVSSA:USP7 deubiquitinates ERCC6
See in Reactome
R-HSA-6782131
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782131
Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER
See in Reactome
R-HSA-6782138
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782138
Reaction Name: ERCC5 and RPA bind TC-NER site
See in Reactome
R-HSA-6782141
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782141
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
See in Reactome
R-HSA-6782204
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782204
Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
See in Reactome
R-HSA-6782208
(
R-HSA-6781827;
R-HSA-6782210
)
R-HSA-6782208
Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER
See in Reactome
R-HSA-6782211
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782211
Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site
See in Reactome
R-HSA-6782224
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782224
Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER
See in Reactome
R-HSA-6782227
(
R-HSA-6781827;
R-HSA-6782210
)
R-HSA-6782227
Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER
See in Reactome
R-HSA-6782234
(
R-HSA-6781827
)
R-HSA-6782234
Reaction Name: Recovery of RNA synthesis after TC-NER
See in Reactome
R-HSA-6790454
(
R-HSA-5696395
)
R-HSA-6790487
(
R-HSA-5696395
)
R-HSA-6790487
Reaction Name: RNF111 ubiquitinates SUMOylated XPC
See in Reactome
R-HSA-6797606
(
R-HSA-6796648
)
R-HSA-6797606
Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes
See in Reactome
R-HSA-6797616
(
R-HSA-6796648
)
R-HSA-6797616
Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-73758
(
R-HSA-73762
)
R-HSA-73758
Reaction Name: Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter
See in Reactome
R-HSA-73769
(
R-HSA-73772
)
R-HSA-73769
Reaction Name: Loss of Rrn3 from RNA Polymerase I promoter escape complex
See in Reactome
R-HSA-73946
(
R-HSA-674695
)
R-HSA-73946
Reaction Name: Abortive initiation after formation of the first phosphodiester bond
See in Reactome
R-HSA-74986
(
R-HSA-73772
)
R-HSA-74986
Reaction Name: Elongation of pre-rRNA transcript
See in Reactome
R-HSA-74992
(
R-HSA-73863
)
R-HSA-74992
Reaction Name: Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box
See in Reactome
R-HSA-74993
(
R-HSA-73863
)
R-HSA-74993
Reaction Name: PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box
See in Reactome
R-HSA-74994
(
R-HSA-73863
)
R-HSA-74994
Reaction Name: Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box
See in Reactome
R-HSA-75850
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-75850
Reaction Name: Addition of the third nucleotide on the nascent transcript
See in Reactome
R-HSA-75856
(
R-HSA-674695
)
R-HSA-75856
Reaction Name: Abortive Initiation Before Second Transition
See in Reactome
R-HSA-75861
(
R-HSA-75953;
R-HSA-76042
)
R-HSA-75861
Reaction Name: NTP Binds Active Site of RNA Polymerase II
See in Reactome
R-HSA-75862
(
R-HSA-674695
)
R-HSA-75862
Reaction Name: Fall Back to Closed Pre-initiation Complex
See in Reactome
R-HSA-75864
(
R-HSA-75953;
R-HSA-76042
)
R-HSA-75864
Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released
See in Reactome
R-HSA-75866
(
R-HSA-75953;
R-HSA-76042
)
R-HSA-75866
Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP
See in Reactome
R-HSA-75869
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-75869
Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition
See in Reactome
R-HSA-75873
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-75873
Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript
See in Reactome
R-HSA-75891
(
R-HSA-674695
)
R-HSA-75891
Reaction Name: Abortive Initiation After Second Transition
See in Reactome
R-HSA-75949
(
R-HSA-76042
)
R-HSA-75949
Reaction Name: RNA Polymerase II Promoter Opening: First Transition
See in Reactome
R-HSA-76576
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-76576
Reaction Name: Addition of nucleotides 10 and 11 on the growing transcript: Third Transition
See in Reactome
R-HSA-77068
(
R-HSA-72086;
R-HSA-77075
)
R-HSA-77069
(
R-HSA-72086;
R-HSA-77075
)
R-HSA-77069
Reaction Name: RNA Polymerase II CTD (phosphorylated) binds to CE
See in Reactome
R-HSA-77071
(
R-HSA-77075
)
R-HSA-77071
Reaction Name: Phosphorylation (Ser5) of RNA pol II CTD
See in Reactome
R-HSA-77073
(
R-HSA-72086;
R-HSA-77075
)
R-HSA-77073
Reaction Name: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)
See in Reactome
R-HSA-77077
(
R-HSA-72086
)
R-HSA-77078
(
R-HSA-72086
)
R-HSA-77078
Reaction Name: Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme
See in Reactome
R-HSA-77081
(
R-HSA-72086
)
R-HSA-77081
Reaction Name: Formation of the CE:GMP intermediate complex
See in Reactome
R-HSA-77083
(
R-HSA-72086
)
R-HSA-77083
Reaction Name: Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA
See in Reactome
R-HSA-77085
(
R-HSA-72086
)
R-HSA-77085
Reaction Name: Dissociation of transcript with 5'-GMP from GT
See in Reactome
R-HSA-77090
(
R-HSA-72086
)
R-HSA-77090
Reaction Name: Methylation of GMP-cap by RNA Methyltransferase
See in Reactome
R-HSA-9613494
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-9613494
Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition
See in Reactome
R-HSA-9613497
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-9613497
Reaction Name: Unwinding DNA for the nascent transcript
See in Reactome
R-HSA-9684118
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-9684118
Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER
See in Reactome
|
MONDO:0010215 |
ERCC4 |
Q92889 |
3.1.-.-
|
R-HSA-5696400
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-6783310
R-HSA-5696395
R-HSA-5696395
Reactome Name: Formation of Incision Complex in GG-NER
See in Reactome
R-HSA-6782135
|
R-HSA-5696399
R-HSA-5696399
Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER)
See in Reactome
R-HSA-5696398
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-5693538
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-6781827
R-HSA-6781827
Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER)
See in Reactome
|
DNA Repair
|
R-HSA-109955
(
R-HSA-5696395
)
R-HSA-109955
Reaction Name: Formation of ERCC1:XPF heterodimeric complex
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5690213
(
R-HSA-5696400
)
R-HSA-5690213
Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site
See in Reactome
R-HSA-5690988
(
R-HSA-5696400
)
R-HSA-5690988
Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER
See in Reactome
R-HSA-5690990
(
R-HSA-5696400
)
R-HSA-5690990
Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER
See in Reactome
R-HSA-5690991
(
R-HSA-5696395
)
R-HSA-5690991
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER
See in Reactome
R-HSA-6782141
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782141
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
See in Reactome
R-HSA-6782204
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782204
Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
See in Reactome
R-HSA-6782211
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782211
Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site
See in Reactome
R-HSA-6782224
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782224
Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER
See in Reactome
R-HSA-6785732
(
R-HSA-6783310
)
R-HSA-6785732
Reaction Name: DNA nucleases bind monoubiquitinated ID2 complex
See in Reactome
R-HSA-6785986
(
R-HSA-6783310
)
R-HSA-6785986
Reaction Name: DNA nucleases unhook the interstrand crosslink (ICL)
See in Reactome
|
MONDO:0010216 |
ERCC5 |
P28715 |
3.1.-.-
|
R-HSA-5696400
R-HSA-5696395
R-HSA-5696395
Reactome Name: Formation of Incision Complex in GG-NER
See in Reactome
R-HSA-6782135
|
R-HSA-73894
R-HSA-6781827
R-HSA-6781827
Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER)
See in Reactome
R-HSA-5696398
R-HSA-5696399
R-HSA-5696399
Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER)
See in Reactome
|
DNA Repair
|
R-HSA-5689317
(
R-HSA-5696395
)
R-HSA-5689317
Reaction Name: Formation of the pre-incision complex in GG-NER
See in Reactome
R-HSA-5690213
(
R-HSA-5696400
)
R-HSA-5690213
Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site
See in Reactome
R-HSA-5690988
(
R-HSA-5696400
)
R-HSA-5690988
Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER
See in Reactome
R-HSA-5690990
(
R-HSA-5696400
)
R-HSA-5690990
Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER
See in Reactome
R-HSA-5690991
(
R-HSA-5696395
)
R-HSA-5690991
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER
See in Reactome
R-HSA-6782138
(
R-HSA-6782135
)
R-HSA-6782138
Reaction Name: ERCC5 and RPA bind TC-NER site
See in Reactome
R-HSA-6782141
(
R-HSA-6782135
)
R-HSA-6782141
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
See in Reactome
R-HSA-6782204
(
R-HSA-6782135
)
R-HSA-6782204
Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
See in Reactome
R-HSA-6782211
(
R-HSA-6782135
)
R-HSA-6782211
Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site
See in Reactome
R-HSA-6782224
(
R-HSA-6782135
)
R-HSA-6782224
Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER
See in Reactome
|
MONDO:0011125 |
ERCC2 |
P18074 |
3.6.4.12
|
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-6782135
R-HSA-6782210
R-HSA-6782210
Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER
See in Reactome
R-HSA-73776
R-HSA-73776
Reactome Name: RNA Polymerase II Promoter Escape
See in Reactome
R-HSA-73779
R-HSA-73779
Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
See in Reactome
R-HSA-674695
R-HSA-674695
Reactome Name: RNA Polymerase II Pre-transcription Events
See in Reactome
R-HSA-76042
R-HSA-76042
Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance
See in Reactome
R-HSA-427413
R-HSA-427413
Reactome Name: NoRC negatively regulates rRNA expression
See in Reactome
R-HSA-6781827
R-HSA-6781827
Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER)
See in Reactome
R-HSA-6781823
R-HSA-6781823
Reactome Name: Formation of TC-NER Pre-Incision Complex
See in Reactome
R-HSA-5696395
R-HSA-5696395
Reactome Name: Formation of Incision Complex in GG-NER
See in Reactome
R-HSA-72086
R-HSA-5696400
R-HSA-77075
R-HSA-77075
Reactome Name: RNA Pol II CTD phosphorylation and interaction with CE
See in Reactome
R-HSA-73762
R-HSA-73762
Reactome Name: RNA Polymerase I Transcription Initiation
See in Reactome
R-HSA-73863
R-HSA-73863
Reactome Name: RNA Polymerase I Transcription Termination
See in Reactome
R-HSA-112382
R-HSA-112382
Reactome Name: Formation of RNA Pol II elongation complex
See in Reactome
R-HSA-2564830
R-HSA-2564830
Reactome Name: Cytosolic iron-sulfur cluster assembly
See in Reactome
R-HSA-73772
R-HSA-73772
Reactome Name: RNA Polymerase I Promoter Escape
See in Reactome
R-HSA-113418
R-HSA-113418
Reactome Name: Formation of the Early Elongation Complex
See in Reactome
R-HSA-75953
R-HSA-75953
Reactome Name: RNA Polymerase II Transcription Initiation
See in Reactome
R-HSA-75955
R-HSA-75955
Reactome Name: RNA Polymerase II Transcription Elongation
See in Reactome
|
R-HSA-5250941
R-HSA-5250941
Reactome Name: Negative epigenetic regulation of rRNA expression
See in Reactome
R-HSA-5696398
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-5696399
R-HSA-5696399
Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER)
See in Reactome
R-HSA-8953854
R-HSA-1430728
R-HSA-212165
R-HSA-212165
Reactome Name: Epigenetic regulation of gene expression
See in Reactome
R-HSA-73894
R-HSA-73864
R-HSA-73854
R-HSA-73854
Reactome Name: RNA Polymerase I Promoter Clearance
See in Reactome
R-HSA-73857
|
Gene expression (Transcription)
Metabolism of RNA
Metabolism
DNA Repair
|
R-HSA-109639
(
R-HSA-73779
)
R-HSA-109639
Reaction Name: Formation of the closed pre-initiation complex
See in Reactome
R-HSA-111264
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-111264
Reaction Name: Addition of nucleotides between position +11 and +30
See in Reactome
R-HSA-112379
(
R-HSA-112382;
R-HSA-75955
)
R-HSA-112379
Reaction Name: Recruitment of elongation factors to form elongation complex
See in Reactome
R-HSA-112383
(
R-HSA-113418;
R-HSA-75955
)
R-HSA-112383
Reaction Name: Hypophosphorylation of RNA Pol II CTD by FCP1P protein
See in Reactome
R-HSA-112385
(
R-HSA-75955
)
R-HSA-112385
Reaction Name: Addition of nucleotides leads to transcript elongation
See in Reactome
R-HSA-113430
(
R-HSA-77075
)
R-HSA-113430
Reaction Name: Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex
See in Reactome
R-HSA-2564828
(
R-HSA-2564830
)
R-HSA-2564828
Reaction Name: CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins
See in Reactome
R-HSA-427366
(
R-HSA-427413
)
R-HSA-427366
Reaction Name: Transcription of intergenic spacer of the rRNA gene
See in Reactome
R-HSA-5689317
(
R-HSA-5696395
)
R-HSA-5689317
Reaction Name: Formation of the pre-incision complex in GG-NER
See in Reactome
R-HSA-5689861
(
R-HSA-5696395
)
R-HSA-5689861
Reaction Name: Recruitment of XPA and release of CAK
See in Reactome
R-HSA-5690213
(
R-HSA-5696400
)
R-HSA-5690213
Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site
See in Reactome
R-HSA-5690988
(
R-HSA-5696400
)
R-HSA-5690988
Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER
See in Reactome
R-HSA-5690990
(
R-HSA-5696400
)
R-HSA-5690990
Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER
See in Reactome
R-HSA-5690991
(
R-HSA-5696395
)
R-HSA-5690991
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER
See in Reactome
R-HSA-5690996
(
R-HSA-5696395
)
R-HSA-5690996
Reaction Name: ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA
See in Reactome
R-HSA-5691000
(
R-HSA-5696395
)
R-HSA-5691000
Reaction Name: TFIIH binds GG-NER site to form a verification complex
See in Reactome
R-HSA-5696670
(
R-HSA-5696395
)
R-HSA-5696670
Reaction Name: CHD1L is recruited to GG-NER site
See in Reactome
R-HSA-6781818
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781818
Reaction Name: RNA Pol II initiates transcription from damaged DNA template
See in Reactome
R-HSA-6781824
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781824
Reaction Name: Active RNA Pol II complex transcribes lesion-containing DNA template
See in Reactome
R-HSA-6781833
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781833
Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II
See in Reactome
R-HSA-6781840
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781840
Reaction Name: ERCC6 binds stalled RNA Pol II
See in Reactome
R-HSA-6781867
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781867
Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II
See in Reactome
R-HSA-6782004
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6782004
Reaction Name: Assembly of the pre-incision complex in TC-NER
See in Reactome
R-HSA-6782069
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6782069
Reaction Name: UVSSA:USP7 deubiquitinates ERCC6
See in Reactome
R-HSA-6782131
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782131
Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER
See in Reactome
R-HSA-6782138
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782138
Reaction Name: ERCC5 and RPA bind TC-NER site
See in Reactome
R-HSA-6782141
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782141
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
See in Reactome
R-HSA-6782204
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782204
Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
See in Reactome
R-HSA-6782208
(
R-HSA-6781827;
R-HSA-6782210
)
R-HSA-6782208
Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER
See in Reactome
R-HSA-6782211
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782211
Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site
See in Reactome
R-HSA-6782224
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782224
Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER
See in Reactome
R-HSA-6782227
(
R-HSA-6781827;
R-HSA-6782210
)
R-HSA-6782227
Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER
See in Reactome
R-HSA-6782234
(
R-HSA-6781827
)
R-HSA-6782234
Reaction Name: Recovery of RNA synthesis after TC-NER
See in Reactome
R-HSA-6790454
(
R-HSA-5696395
)
R-HSA-6790487
(
R-HSA-5696395
)
R-HSA-6790487
Reaction Name: RNF111 ubiquitinates SUMOylated XPC
See in Reactome
R-HSA-6797606
(
R-HSA-6796648
)
R-HSA-6797606
Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes
See in Reactome
R-HSA-6797616
(
R-HSA-6796648
)
R-HSA-6797616
Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-73758
(
R-HSA-73762
)
R-HSA-73758
Reaction Name: Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter
See in Reactome
R-HSA-73769
(
R-HSA-73772
)
R-HSA-73769
Reaction Name: Loss of Rrn3 from RNA Polymerase I promoter escape complex
See in Reactome
R-HSA-73946
(
R-HSA-674695
)
R-HSA-73946
Reaction Name: Abortive initiation after formation of the first phosphodiester bond
See in Reactome
R-HSA-74986
(
R-HSA-73772
)
R-HSA-74986
Reaction Name: Elongation of pre-rRNA transcript
See in Reactome
R-HSA-74992
(
R-HSA-73863
)
R-HSA-74992
Reaction Name: Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box
See in Reactome
R-HSA-74993
(
R-HSA-73863
)
R-HSA-74993
Reaction Name: PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box
See in Reactome
R-HSA-74994
(
R-HSA-73863
)
R-HSA-74994
Reaction Name: Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box
See in Reactome
R-HSA-75850
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-75850
Reaction Name: Addition of the third nucleotide on the nascent transcript
See in Reactome
R-HSA-75856
(
R-HSA-674695
)
R-HSA-75856
Reaction Name: Abortive Initiation Before Second Transition
See in Reactome
R-HSA-75861
(
R-HSA-75953;
R-HSA-76042
)
R-HSA-75861
Reaction Name: NTP Binds Active Site of RNA Polymerase II
See in Reactome
R-HSA-75862
(
R-HSA-674695
)
R-HSA-75862
Reaction Name: Fall Back to Closed Pre-initiation Complex
See in Reactome
R-HSA-75864
(
R-HSA-75953;
R-HSA-76042
)
R-HSA-75864
Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released
See in Reactome
R-HSA-75866
(
R-HSA-75953;
R-HSA-76042
)
R-HSA-75866
Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP
See in Reactome
R-HSA-75869
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-75869
Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition
See in Reactome
R-HSA-75873
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-75873
Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript
See in Reactome
R-HSA-75891
(
R-HSA-674695
)
R-HSA-75891
Reaction Name: Abortive Initiation After Second Transition
See in Reactome
R-HSA-75949
(
R-HSA-76042
)
R-HSA-75949
Reaction Name: RNA Polymerase II Promoter Opening: First Transition
See in Reactome
R-HSA-76576
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-76576
Reaction Name: Addition of nucleotides 10 and 11 on the growing transcript: Third Transition
See in Reactome
R-HSA-77068
(
R-HSA-72086;
R-HSA-77075
)
R-HSA-77069
(
R-HSA-72086;
R-HSA-77075
)
R-HSA-77069
Reaction Name: RNA Polymerase II CTD (phosphorylated) binds to CE
See in Reactome
R-HSA-77071
(
R-HSA-77075
)
R-HSA-77071
Reaction Name: Phosphorylation (Ser5) of RNA pol II CTD
See in Reactome
R-HSA-77073
(
R-HSA-72086;
R-HSA-77075
)
R-HSA-77073
Reaction Name: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)
See in Reactome
R-HSA-77077
(
R-HSA-72086
)
R-HSA-77078
(
R-HSA-72086
)
R-HSA-77078
Reaction Name: Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme
See in Reactome
R-HSA-77081
(
R-HSA-72086
)
R-HSA-77081
Reaction Name: Formation of the CE:GMP intermediate complex
See in Reactome
R-HSA-77083
(
R-HSA-72086
)
R-HSA-77083
Reaction Name: Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA
See in Reactome
R-HSA-77085
(
R-HSA-72086
)
R-HSA-77085
Reaction Name: Dissociation of transcript with 5'-GMP from GT
See in Reactome
R-HSA-77090
(
R-HSA-72086
)
R-HSA-77090
Reaction Name: Methylation of GMP-cap by RNA Methyltransferase
See in Reactome
R-HSA-9613494
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-9613494
Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition
See in Reactome
R-HSA-9613497
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-9613497
Reaction Name: Unwinding DNA for the nascent transcript
See in Reactome
R-HSA-9684118
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-9684118
Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER
See in Reactome
|
MONDO:0012531 |
ERCC3 |
P19447 |
3.6.4.12
|
R-HSA-75955
R-HSA-75955
Reactome Name: RNA Polymerase II Transcription Elongation
See in Reactome
R-HSA-112382
R-HSA-112382
Reactome Name: Formation of RNA Pol II elongation complex
See in Reactome
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-5696395
R-HSA-5696395
Reactome Name: Formation of Incision Complex in GG-NER
See in Reactome
R-HSA-427413
R-HSA-427413
Reactome Name: NoRC negatively regulates rRNA expression
See in Reactome
R-HSA-6781827
R-HSA-6781827
Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER)
See in Reactome
R-HSA-5696400
R-HSA-6781823
R-HSA-6781823
Reactome Name: Formation of TC-NER Pre-Incision Complex
See in Reactome
R-HSA-6782135
R-HSA-75953
R-HSA-75953
Reactome Name: RNA Polymerase II Transcription Initiation
See in Reactome
R-HSA-6782210
R-HSA-6782210
Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER
See in Reactome
R-HSA-73762
R-HSA-73762
Reactome Name: RNA Polymerase I Transcription Initiation
See in Reactome
R-HSA-73863
R-HSA-73863
Reactome Name: RNA Polymerase I Transcription Termination
See in Reactome
R-HSA-73776
R-HSA-73776
Reactome Name: RNA Polymerase II Promoter Escape
See in Reactome
R-HSA-73779
R-HSA-73779
Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
See in Reactome
R-HSA-76042
R-HSA-76042
Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance
See in Reactome
R-HSA-77075
R-HSA-77075
Reactome Name: RNA Pol II CTD phosphorylation and interaction with CE
See in Reactome
R-HSA-73772
R-HSA-73772
Reactome Name: RNA Polymerase I Promoter Escape
See in Reactome
R-HSA-72086
R-HSA-113418
R-HSA-113418
Reactome Name: Formation of the Early Elongation Complex
See in Reactome
R-HSA-674695
R-HSA-674695
Reactome Name: RNA Polymerase II Pre-transcription Events
See in Reactome
|
R-HSA-5250941
R-HSA-5250941
Reactome Name: Negative epigenetic regulation of rRNA expression
See in Reactome
R-HSA-5696398
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-5696399
R-HSA-5696399
Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER)
See in Reactome
R-HSA-8953854
R-HSA-212165
R-HSA-212165
Reactome Name: Epigenetic regulation of gene expression
See in Reactome
R-HSA-73894
R-HSA-73864
R-HSA-73854
R-HSA-73854
Reactome Name: RNA Polymerase I Promoter Clearance
See in Reactome
R-HSA-73857
|
Gene expression (Transcription)
Metabolism of RNA
DNA Repair
|
R-HSA-109639
(
R-HSA-73779
)
R-HSA-109639
Reaction Name: Formation of the closed pre-initiation complex
See in Reactome
R-HSA-111264
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-111264
Reaction Name: Addition of nucleotides between position +11 and +30
See in Reactome
R-HSA-112379
(
R-HSA-112382;
R-HSA-75955
)
R-HSA-112379
Reaction Name: Recruitment of elongation factors to form elongation complex
See in Reactome
R-HSA-112383
(
R-HSA-113418;
R-HSA-75955
)
R-HSA-112383
Reaction Name: Hypophosphorylation of RNA Pol II CTD by FCP1P protein
See in Reactome
R-HSA-112385
(
R-HSA-75955
)
R-HSA-112385
Reaction Name: Addition of nucleotides leads to transcript elongation
See in Reactome
R-HSA-113430
(
R-HSA-77075
)
R-HSA-113430
Reaction Name: Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex
See in Reactome
R-HSA-427366
(
R-HSA-427413
)
R-HSA-427366
Reaction Name: Transcription of intergenic spacer of the rRNA gene
See in Reactome
R-HSA-5689317
(
R-HSA-5696395
)
R-HSA-5689317
Reaction Name: Formation of the pre-incision complex in GG-NER
See in Reactome
R-HSA-5689861
(
R-HSA-5696395
)
R-HSA-5689861
Reaction Name: Recruitment of XPA and release of CAK
See in Reactome
R-HSA-5690213
(
R-HSA-5696400
)
R-HSA-5690213
Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site
See in Reactome
R-HSA-5690988
(
R-HSA-5696400
)
R-HSA-5690988
Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER
See in Reactome
R-HSA-5690990
(
R-HSA-5696400
)
R-HSA-5690990
Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER
See in Reactome
R-HSA-5690991
(
R-HSA-5696395
)
R-HSA-5690991
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER
See in Reactome
R-HSA-5690996
(
R-HSA-5696395
)
R-HSA-5690996
Reaction Name: ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA
See in Reactome
R-HSA-5691000
(
R-HSA-5696395
)
R-HSA-5691000
Reaction Name: TFIIH binds GG-NER site to form a verification complex
See in Reactome
R-HSA-5696670
(
R-HSA-5696395
)
R-HSA-5696670
Reaction Name: CHD1L is recruited to GG-NER site
See in Reactome
R-HSA-6781818
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781818
Reaction Name: RNA Pol II initiates transcription from damaged DNA template
See in Reactome
R-HSA-6781824
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781824
Reaction Name: Active RNA Pol II complex transcribes lesion-containing DNA template
See in Reactome
R-HSA-6781833
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781833
Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II
See in Reactome
R-HSA-6781840
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781840
Reaction Name: ERCC6 binds stalled RNA Pol II
See in Reactome
R-HSA-6781867
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781867
Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II
See in Reactome
R-HSA-6782004
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6782004
Reaction Name: Assembly of the pre-incision complex in TC-NER
See in Reactome
R-HSA-6782069
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6782069
Reaction Name: UVSSA:USP7 deubiquitinates ERCC6
See in Reactome
R-HSA-6782131
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782131
Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER
See in Reactome
R-HSA-6782138
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782138
Reaction Name: ERCC5 and RPA bind TC-NER site
See in Reactome
R-HSA-6782141
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782141
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
See in Reactome
R-HSA-6782204
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782204
Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
See in Reactome
R-HSA-6782208
(
R-HSA-6781827;
R-HSA-6782210
)
R-HSA-6782208
Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER
See in Reactome
R-HSA-6782211
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782211
Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site
See in Reactome
R-HSA-6782224
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782224
Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER
See in Reactome
R-HSA-6782227
(
R-HSA-6781827;
R-HSA-6782210
)
R-HSA-6782227
Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER
See in Reactome
R-HSA-6782234
(
R-HSA-6781827
)
R-HSA-6782234
Reaction Name: Recovery of RNA synthesis after TC-NER
See in Reactome
R-HSA-6790454
(
R-HSA-5696395
)
R-HSA-6790487
(
R-HSA-5696395
)
R-HSA-6790487
Reaction Name: RNF111 ubiquitinates SUMOylated XPC
See in Reactome
R-HSA-6797606
(
R-HSA-6796648
)
R-HSA-6797606
Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes
See in Reactome
R-HSA-6797616
(
R-HSA-6796648
)
R-HSA-6797616
Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-73758
(
R-HSA-73762
)
R-HSA-73758
Reaction Name: Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter
See in Reactome
R-HSA-73769
(
R-HSA-73772
)
R-HSA-73769
Reaction Name: Loss of Rrn3 from RNA Polymerase I promoter escape complex
See in Reactome
R-HSA-73946
(
R-HSA-674695
)
R-HSA-73946
Reaction Name: Abortive initiation after formation of the first phosphodiester bond
See in Reactome
R-HSA-74986
(
R-HSA-73772
)
R-HSA-74986
Reaction Name: Elongation of pre-rRNA transcript
See in Reactome
R-HSA-74992
(
R-HSA-73863
)
R-HSA-74992
Reaction Name: Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box
See in Reactome
R-HSA-74993
(
R-HSA-73863
)
R-HSA-74993
Reaction Name: PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box
See in Reactome
R-HSA-74994
(
R-HSA-73863
)
R-HSA-74994
Reaction Name: Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box
See in Reactome
R-HSA-75850
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-75850
Reaction Name: Addition of the third nucleotide on the nascent transcript
See in Reactome
R-HSA-75856
(
R-HSA-674695
)
R-HSA-75856
Reaction Name: Abortive Initiation Before Second Transition
See in Reactome
R-HSA-75861
(
R-HSA-75953;
R-HSA-76042
)
R-HSA-75861
Reaction Name: NTP Binds Active Site of RNA Polymerase II
See in Reactome
R-HSA-75862
(
R-HSA-674695
)
R-HSA-75862
Reaction Name: Fall Back to Closed Pre-initiation Complex
See in Reactome
R-HSA-75864
(
R-HSA-75953;
R-HSA-76042
)
R-HSA-75864
Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released
See in Reactome
R-HSA-75866
(
R-HSA-75953;
R-HSA-76042
)
R-HSA-75866
Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP
See in Reactome
R-HSA-75869
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-75869
Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition
See in Reactome
R-HSA-75873
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-75873
Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript
See in Reactome
R-HSA-75891
(
R-HSA-674695
)
R-HSA-75891
Reaction Name: Abortive Initiation After Second Transition
See in Reactome
R-HSA-75949
(
R-HSA-76042
)
R-HSA-75949
Reaction Name: RNA Polymerase II Promoter Opening: First Transition
See in Reactome
R-HSA-76576
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-76576
Reaction Name: Addition of nucleotides 10 and 11 on the growing transcript: Third Transition
See in Reactome
R-HSA-77068
(
R-HSA-72086;
R-HSA-77075
)
R-HSA-77069
(
R-HSA-72086;
R-HSA-77075
)
R-HSA-77069
Reaction Name: RNA Polymerase II CTD (phosphorylated) binds to CE
See in Reactome
R-HSA-77071
(
R-HSA-77075
)
R-HSA-77071
Reaction Name: Phosphorylation (Ser5) of RNA pol II CTD
See in Reactome
R-HSA-77073
(
R-HSA-72086;
R-HSA-77075
)
R-HSA-77073
Reaction Name: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)
See in Reactome
R-HSA-77077
(
R-HSA-72086
)
R-HSA-77078
(
R-HSA-72086
)
R-HSA-77078
Reaction Name: Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme
See in Reactome
R-HSA-77081
(
R-HSA-72086
)
R-HSA-77081
Reaction Name: Formation of the CE:GMP intermediate complex
See in Reactome
R-HSA-77083
(
R-HSA-72086
)
R-HSA-77083
Reaction Name: Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA
See in Reactome
R-HSA-77085
(
R-HSA-72086
)
R-HSA-77085
Reaction Name: Dissociation of transcript with 5'-GMP from GT
See in Reactome
R-HSA-77090
(
R-HSA-72086
)
R-HSA-77090
Reaction Name: Methylation of GMP-cap by RNA Methyltransferase
See in Reactome
R-HSA-9613494
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-9613494
Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition
See in Reactome
R-HSA-9613497
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-9613497
Reaction Name: Unwinding DNA for the nascent transcript
See in Reactome
R-HSA-9684118
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-9684118
Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER
See in Reactome
|
MONDO:0012553 |
ERCC2 |
P18074 |
3.6.4.12
|
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-6782135
R-HSA-6782210
R-HSA-6782210
Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER
See in Reactome
R-HSA-73776
R-HSA-73776
Reactome Name: RNA Polymerase II Promoter Escape
See in Reactome
R-HSA-73779
R-HSA-73779
Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
See in Reactome
R-HSA-674695
R-HSA-674695
Reactome Name: RNA Polymerase II Pre-transcription Events
See in Reactome
R-HSA-76042
R-HSA-76042
Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance
See in Reactome
R-HSA-427413
R-HSA-427413
Reactome Name: NoRC negatively regulates rRNA expression
See in Reactome
R-HSA-6781827
R-HSA-6781827
Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER)
See in Reactome
R-HSA-6781823
R-HSA-6781823
Reactome Name: Formation of TC-NER Pre-Incision Complex
See in Reactome
R-HSA-5696395
R-HSA-5696395
Reactome Name: Formation of Incision Complex in GG-NER
See in Reactome
R-HSA-72086
R-HSA-5696400
R-HSA-77075
R-HSA-77075
Reactome Name: RNA Pol II CTD phosphorylation and interaction with CE
See in Reactome
R-HSA-73762
R-HSA-73762
Reactome Name: RNA Polymerase I Transcription Initiation
See in Reactome
R-HSA-73863
R-HSA-73863
Reactome Name: RNA Polymerase I Transcription Termination
See in Reactome
R-HSA-112382
R-HSA-112382
Reactome Name: Formation of RNA Pol II elongation complex
See in Reactome
R-HSA-2564830
R-HSA-2564830
Reactome Name: Cytosolic iron-sulfur cluster assembly
See in Reactome
R-HSA-73772
R-HSA-73772
Reactome Name: RNA Polymerase I Promoter Escape
See in Reactome
R-HSA-113418
R-HSA-113418
Reactome Name: Formation of the Early Elongation Complex
See in Reactome
R-HSA-75953
R-HSA-75953
Reactome Name: RNA Polymerase II Transcription Initiation
See in Reactome
R-HSA-75955
R-HSA-75955
Reactome Name: RNA Polymerase II Transcription Elongation
See in Reactome
|
R-HSA-5250941
R-HSA-5250941
Reactome Name: Negative epigenetic regulation of rRNA expression
See in Reactome
R-HSA-5696398
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-5696399
R-HSA-5696399
Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER)
See in Reactome
R-HSA-8953854
R-HSA-1430728
R-HSA-212165
R-HSA-212165
Reactome Name: Epigenetic regulation of gene expression
See in Reactome
R-HSA-73894
R-HSA-73864
R-HSA-73854
R-HSA-73854
Reactome Name: RNA Polymerase I Promoter Clearance
See in Reactome
R-HSA-73857
|
Gene expression (Transcription)
Metabolism of RNA
Metabolism
DNA Repair
|
R-HSA-109639
(
R-HSA-73779
)
R-HSA-109639
Reaction Name: Formation of the closed pre-initiation complex
See in Reactome
R-HSA-111264
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-111264
Reaction Name: Addition of nucleotides between position +11 and +30
See in Reactome
R-HSA-112379
(
R-HSA-112382;
R-HSA-75955
)
R-HSA-112379
Reaction Name: Recruitment of elongation factors to form elongation complex
See in Reactome
R-HSA-112383
(
R-HSA-113418;
R-HSA-75955
)
R-HSA-112383
Reaction Name: Hypophosphorylation of RNA Pol II CTD by FCP1P protein
See in Reactome
R-HSA-112385
(
R-HSA-75955
)
R-HSA-112385
Reaction Name: Addition of nucleotides leads to transcript elongation
See in Reactome
R-HSA-113430
(
R-HSA-77075
)
R-HSA-113430
Reaction Name: Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex
See in Reactome
R-HSA-2564828
(
R-HSA-2564830
)
R-HSA-2564828
Reaction Name: CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins
See in Reactome
R-HSA-427366
(
R-HSA-427413
)
R-HSA-427366
Reaction Name: Transcription of intergenic spacer of the rRNA gene
See in Reactome
R-HSA-5689317
(
R-HSA-5696395
)
R-HSA-5689317
Reaction Name: Formation of the pre-incision complex in GG-NER
See in Reactome
R-HSA-5689861
(
R-HSA-5696395
)
R-HSA-5689861
Reaction Name: Recruitment of XPA and release of CAK
See in Reactome
R-HSA-5690213
(
R-HSA-5696400
)
R-HSA-5690213
Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site
See in Reactome
R-HSA-5690988
(
R-HSA-5696400
)
R-HSA-5690988
Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER
See in Reactome
R-HSA-5690990
(
R-HSA-5696400
)
R-HSA-5690990
Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER
See in Reactome
R-HSA-5690991
(
R-HSA-5696395
)
R-HSA-5690991
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER
See in Reactome
R-HSA-5690996
(
R-HSA-5696395
)
R-HSA-5690996
Reaction Name: ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA
See in Reactome
R-HSA-5691000
(
R-HSA-5696395
)
R-HSA-5691000
Reaction Name: TFIIH binds GG-NER site to form a verification complex
See in Reactome
R-HSA-5696670
(
R-HSA-5696395
)
R-HSA-5696670
Reaction Name: CHD1L is recruited to GG-NER site
See in Reactome
R-HSA-6781818
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781818
Reaction Name: RNA Pol II initiates transcription from damaged DNA template
See in Reactome
R-HSA-6781824
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781824
Reaction Name: Active RNA Pol II complex transcribes lesion-containing DNA template
See in Reactome
R-HSA-6781833
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781833
Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II
See in Reactome
R-HSA-6781840
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781840
Reaction Name: ERCC6 binds stalled RNA Pol II
See in Reactome
R-HSA-6781867
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781867
Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II
See in Reactome
R-HSA-6782004
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6782004
Reaction Name: Assembly of the pre-incision complex in TC-NER
See in Reactome
R-HSA-6782069
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6782069
Reaction Name: UVSSA:USP7 deubiquitinates ERCC6
See in Reactome
R-HSA-6782131
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782131
Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER
See in Reactome
R-HSA-6782138
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782138
Reaction Name: ERCC5 and RPA bind TC-NER site
See in Reactome
R-HSA-6782141
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782141
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
See in Reactome
R-HSA-6782204
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782204
Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
See in Reactome
R-HSA-6782208
(
R-HSA-6781827;
R-HSA-6782210
)
R-HSA-6782208
Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER
See in Reactome
R-HSA-6782211
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782211
Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site
See in Reactome
R-HSA-6782224
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782224
Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER
See in Reactome
R-HSA-6782227
(
R-HSA-6781827;
R-HSA-6782210
)
R-HSA-6782227
Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER
See in Reactome
R-HSA-6782234
(
R-HSA-6781827
)
R-HSA-6782234
Reaction Name: Recovery of RNA synthesis after TC-NER
See in Reactome
R-HSA-6790454
(
R-HSA-5696395
)
R-HSA-6790487
(
R-HSA-5696395
)
R-HSA-6790487
Reaction Name: RNF111 ubiquitinates SUMOylated XPC
See in Reactome
R-HSA-6797606
(
R-HSA-6796648
)
R-HSA-6797606
Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes
See in Reactome
R-HSA-6797616
(
R-HSA-6796648
)
R-HSA-6797616
Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-73758
(
R-HSA-73762
)
R-HSA-73758
Reaction Name: Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter
See in Reactome
R-HSA-73769
(
R-HSA-73772
)
R-HSA-73769
Reaction Name: Loss of Rrn3 from RNA Polymerase I promoter escape complex
See in Reactome
R-HSA-73946
(
R-HSA-674695
)
R-HSA-73946
Reaction Name: Abortive initiation after formation of the first phosphodiester bond
See in Reactome
R-HSA-74986
(
R-HSA-73772
)
R-HSA-74986
Reaction Name: Elongation of pre-rRNA transcript
See in Reactome
R-HSA-74992
(
R-HSA-73863
)
R-HSA-74992
Reaction Name: Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box
See in Reactome
R-HSA-74993
(
R-HSA-73863
)
R-HSA-74993
Reaction Name: PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box
See in Reactome
R-HSA-74994
(
R-HSA-73863
)
R-HSA-74994
Reaction Name: Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box
See in Reactome
R-HSA-75850
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-75850
Reaction Name: Addition of the third nucleotide on the nascent transcript
See in Reactome
R-HSA-75856
(
R-HSA-674695
)
R-HSA-75856
Reaction Name: Abortive Initiation Before Second Transition
See in Reactome
R-HSA-75861
(
R-HSA-75953;
R-HSA-76042
)
R-HSA-75861
Reaction Name: NTP Binds Active Site of RNA Polymerase II
See in Reactome
R-HSA-75862
(
R-HSA-674695
)
R-HSA-75862
Reaction Name: Fall Back to Closed Pre-initiation Complex
See in Reactome
R-HSA-75864
(
R-HSA-75953;
R-HSA-76042
)
R-HSA-75864
Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released
See in Reactome
R-HSA-75866
(
R-HSA-75953;
R-HSA-76042
)
R-HSA-75866
Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP
See in Reactome
R-HSA-75869
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-75869
Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition
See in Reactome
R-HSA-75873
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-75873
Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript
See in Reactome
R-HSA-75891
(
R-HSA-674695
)
R-HSA-75891
Reaction Name: Abortive Initiation After Second Transition
See in Reactome
R-HSA-75949
(
R-HSA-76042
)
R-HSA-75949
Reaction Name: RNA Polymerase II Promoter Opening: First Transition
See in Reactome
R-HSA-76576
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-76576
Reaction Name: Addition of nucleotides 10 and 11 on the growing transcript: Third Transition
See in Reactome
R-HSA-77068
(
R-HSA-72086;
R-HSA-77075
)
R-HSA-77069
(
R-HSA-72086;
R-HSA-77075
)
R-HSA-77069
Reaction Name: RNA Polymerase II CTD (phosphorylated) binds to CE
See in Reactome
R-HSA-77071
(
R-HSA-77075
)
R-HSA-77071
Reaction Name: Phosphorylation (Ser5) of RNA pol II CTD
See in Reactome
R-HSA-77073
(
R-HSA-72086;
R-HSA-77075
)
R-HSA-77073
Reaction Name: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)
See in Reactome
R-HSA-77077
(
R-HSA-72086
)
R-HSA-77078
(
R-HSA-72086
)
R-HSA-77078
Reaction Name: Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme
See in Reactome
R-HSA-77081
(
R-HSA-72086
)
R-HSA-77081
Reaction Name: Formation of the CE:GMP intermediate complex
See in Reactome
R-HSA-77083
(
R-HSA-72086
)
R-HSA-77083
Reaction Name: Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA
See in Reactome
R-HSA-77085
(
R-HSA-72086
)
R-HSA-77085
Reaction Name: Dissociation of transcript with 5'-GMP from GT
See in Reactome
R-HSA-77090
(
R-HSA-72086
)
R-HSA-77090
Reaction Name: Methylation of GMP-cap by RNA Methyltransferase
See in Reactome
R-HSA-9613494
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-9613494
Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition
See in Reactome
R-HSA-9613497
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-9613497
Reaction Name: Unwinding DNA for the nascent transcript
See in Reactome
R-HSA-9684118
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-9684118
Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER
See in Reactome
|
MONDO:0012590 |
ERCC4 |
Q92889 |
3.1.-.-
|
R-HSA-5696400
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-6783310
R-HSA-5696395
R-HSA-5696395
Reactome Name: Formation of Incision Complex in GG-NER
See in Reactome
R-HSA-6782135
|
R-HSA-5696399
R-HSA-5696399
Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER)
See in Reactome
R-HSA-5696398
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-5693538
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-6781827
R-HSA-6781827
Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER)
See in Reactome
|
DNA Repair
|
R-HSA-109955
(
R-HSA-5696395
)
R-HSA-109955
Reaction Name: Formation of ERCC1:XPF heterodimeric complex
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5690213
(
R-HSA-5696400
)
R-HSA-5690213
Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site
See in Reactome
R-HSA-5690988
(
R-HSA-5696400
)
R-HSA-5690988
Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER
See in Reactome
R-HSA-5690990
(
R-HSA-5696400
)
R-HSA-5690990
Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER
See in Reactome
R-HSA-5690991
(
R-HSA-5696395
)
R-HSA-5690991
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER
See in Reactome
R-HSA-6782141
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782141
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
See in Reactome
R-HSA-6782204
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782204
Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
See in Reactome
R-HSA-6782211
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782211
Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site
See in Reactome
R-HSA-6782224
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782224
Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER
See in Reactome
R-HSA-6785732
(
R-HSA-6783310
)
R-HSA-6785732
Reaction Name: DNA nucleases bind monoubiquitinated ID2 complex
See in Reactome
R-HSA-6785986
(
R-HSA-6783310
)
R-HSA-6785986
Reaction Name: DNA nucleases unhook the interstrand crosslink (ICL)
See in Reactome
|
MONDO:0014108 |
ERCC4 |
Q92889 |
3.1.-.-
|
R-HSA-5696400
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-6783310
R-HSA-5696395
R-HSA-5696395
Reactome Name: Formation of Incision Complex in GG-NER
See in Reactome
R-HSA-6782135
|
R-HSA-5696399
R-HSA-5696399
Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER)
See in Reactome
R-HSA-5696398
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-5693538
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-6781827
R-HSA-6781827
Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER)
See in Reactome
|
DNA Repair
|
R-HSA-109955
(
R-HSA-5696395
)
R-HSA-109955
Reaction Name: Formation of ERCC1:XPF heterodimeric complex
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5690213
(
R-HSA-5696400
)
R-HSA-5690213
Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site
See in Reactome
R-HSA-5690988
(
R-HSA-5696400
)
R-HSA-5690988
Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER
See in Reactome
R-HSA-5690990
(
R-HSA-5696400
)
R-HSA-5690990
Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER
See in Reactome
R-HSA-5690991
(
R-HSA-5696395
)
R-HSA-5690991
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER
See in Reactome
R-HSA-6782141
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782141
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
See in Reactome
R-HSA-6782204
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782204
Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
See in Reactome
R-HSA-6782211
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782211
Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site
See in Reactome
R-HSA-6782224
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782224
Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER
See in Reactome
R-HSA-6785732
(
R-HSA-6783310
)
R-HSA-6785732
Reaction Name: DNA nucleases bind monoubiquitinated ID2 complex
See in Reactome
R-HSA-6785986
(
R-HSA-6783310
)
R-HSA-6785986
Reaction Name: DNA nucleases unhook the interstrand crosslink (ICL)
See in Reactome
|
MONDO:0014615 |
ERCC3 |
P19447 |
3.6.4.12
|
R-HSA-75955
R-HSA-75955
Reactome Name: RNA Polymerase II Transcription Elongation
See in Reactome
R-HSA-112382
R-HSA-112382
Reactome Name: Formation of RNA Pol II elongation complex
See in Reactome
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-5696395
R-HSA-5696395
Reactome Name: Formation of Incision Complex in GG-NER
See in Reactome
R-HSA-427413
R-HSA-427413
Reactome Name: NoRC negatively regulates rRNA expression
See in Reactome
R-HSA-6781827
R-HSA-6781827
Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER)
See in Reactome
R-HSA-5696400
R-HSA-6781823
R-HSA-6781823
Reactome Name: Formation of TC-NER Pre-Incision Complex
See in Reactome
R-HSA-6782135
R-HSA-75953
R-HSA-75953
Reactome Name: RNA Polymerase II Transcription Initiation
See in Reactome
R-HSA-6782210
R-HSA-6782210
Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER
See in Reactome
R-HSA-73762
R-HSA-73762
Reactome Name: RNA Polymerase I Transcription Initiation
See in Reactome
R-HSA-73863
R-HSA-73863
Reactome Name: RNA Polymerase I Transcription Termination
See in Reactome
R-HSA-73776
R-HSA-73776
Reactome Name: RNA Polymerase II Promoter Escape
See in Reactome
R-HSA-73779
R-HSA-73779
Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
See in Reactome
R-HSA-76042
R-HSA-76042
Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance
See in Reactome
R-HSA-77075
R-HSA-77075
Reactome Name: RNA Pol II CTD phosphorylation and interaction with CE
See in Reactome
R-HSA-73772
R-HSA-73772
Reactome Name: RNA Polymerase I Promoter Escape
See in Reactome
R-HSA-72086
R-HSA-113418
R-HSA-113418
Reactome Name: Formation of the Early Elongation Complex
See in Reactome
R-HSA-674695
R-HSA-674695
Reactome Name: RNA Polymerase II Pre-transcription Events
See in Reactome
|
R-HSA-5250941
R-HSA-5250941
Reactome Name: Negative epigenetic regulation of rRNA expression
See in Reactome
R-HSA-5696398
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-5696399
R-HSA-5696399
Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER)
See in Reactome
R-HSA-8953854
R-HSA-212165
R-HSA-212165
Reactome Name: Epigenetic regulation of gene expression
See in Reactome
R-HSA-73894
R-HSA-73864
R-HSA-73854
R-HSA-73854
Reactome Name: RNA Polymerase I Promoter Clearance
See in Reactome
R-HSA-73857
|
Gene expression (Transcription)
Metabolism of RNA
DNA Repair
|
R-HSA-109639
(
R-HSA-73779
)
R-HSA-109639
Reaction Name: Formation of the closed pre-initiation complex
See in Reactome
R-HSA-111264
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-111264
Reaction Name: Addition of nucleotides between position +11 and +30
See in Reactome
R-HSA-112379
(
R-HSA-112382;
R-HSA-75955
)
R-HSA-112379
Reaction Name: Recruitment of elongation factors to form elongation complex
See in Reactome
R-HSA-112383
(
R-HSA-113418;
R-HSA-75955
)
R-HSA-112383
Reaction Name: Hypophosphorylation of RNA Pol II CTD by FCP1P protein
See in Reactome
R-HSA-112385
(
R-HSA-75955
)
R-HSA-112385
Reaction Name: Addition of nucleotides leads to transcript elongation
See in Reactome
R-HSA-113430
(
R-HSA-77075
)
R-HSA-113430
Reaction Name: Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex
See in Reactome
R-HSA-427366
(
R-HSA-427413
)
R-HSA-427366
Reaction Name: Transcription of intergenic spacer of the rRNA gene
See in Reactome
R-HSA-5689317
(
R-HSA-5696395
)
R-HSA-5689317
Reaction Name: Formation of the pre-incision complex in GG-NER
See in Reactome
R-HSA-5689861
(
R-HSA-5696395
)
R-HSA-5689861
Reaction Name: Recruitment of XPA and release of CAK
See in Reactome
R-HSA-5690213
(
R-HSA-5696400
)
R-HSA-5690213
Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site
See in Reactome
R-HSA-5690988
(
R-HSA-5696400
)
R-HSA-5690988
Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER
See in Reactome
R-HSA-5690990
(
R-HSA-5696400
)
R-HSA-5690990
Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER
See in Reactome
R-HSA-5690991
(
R-HSA-5696395
)
R-HSA-5690991
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER
See in Reactome
R-HSA-5690996
(
R-HSA-5696395
)
R-HSA-5690996
Reaction Name: ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA
See in Reactome
R-HSA-5691000
(
R-HSA-5696395
)
R-HSA-5691000
Reaction Name: TFIIH binds GG-NER site to form a verification complex
See in Reactome
R-HSA-5696670
(
R-HSA-5696395
)
R-HSA-5696670
Reaction Name: CHD1L is recruited to GG-NER site
See in Reactome
R-HSA-6781818
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781818
Reaction Name: RNA Pol II initiates transcription from damaged DNA template
See in Reactome
R-HSA-6781824
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781824
Reaction Name: Active RNA Pol II complex transcribes lesion-containing DNA template
See in Reactome
R-HSA-6781833
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781833
Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II
See in Reactome
R-HSA-6781840
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781840
Reaction Name: ERCC6 binds stalled RNA Pol II
See in Reactome
R-HSA-6781867
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781867
Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II
See in Reactome
R-HSA-6782004
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6782004
Reaction Name: Assembly of the pre-incision complex in TC-NER
See in Reactome
R-HSA-6782069
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6782069
Reaction Name: UVSSA:USP7 deubiquitinates ERCC6
See in Reactome
R-HSA-6782131
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782131
Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER
See in Reactome
R-HSA-6782138
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782138
Reaction Name: ERCC5 and RPA bind TC-NER site
See in Reactome
R-HSA-6782141
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782141
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
See in Reactome
R-HSA-6782204
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782204
Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
See in Reactome
R-HSA-6782208
(
R-HSA-6781827;
R-HSA-6782210
)
R-HSA-6782208
Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER
See in Reactome
R-HSA-6782211
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782211
Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site
See in Reactome
R-HSA-6782224
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782224
Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER
See in Reactome
R-HSA-6782227
(
R-HSA-6781827;
R-HSA-6782210
)
R-HSA-6782227
Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER
See in Reactome
R-HSA-6782234
(
R-HSA-6781827
)
R-HSA-6782234
Reaction Name: Recovery of RNA synthesis after TC-NER
See in Reactome
R-HSA-6790454
(
R-HSA-5696395
)
R-HSA-6790487
(
R-HSA-5696395
)
R-HSA-6790487
Reaction Name: RNF111 ubiquitinates SUMOylated XPC
See in Reactome
R-HSA-6797606
(
R-HSA-6796648
)
R-HSA-6797606
Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes
See in Reactome
R-HSA-6797616
(
R-HSA-6796648
)
R-HSA-6797616
Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-73758
(
R-HSA-73762
)
R-HSA-73758
Reaction Name: Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter
See in Reactome
R-HSA-73769
(
R-HSA-73772
)
R-HSA-73769
Reaction Name: Loss of Rrn3 from RNA Polymerase I promoter escape complex
See in Reactome
R-HSA-73946
(
R-HSA-674695
)
R-HSA-73946
Reaction Name: Abortive initiation after formation of the first phosphodiester bond
See in Reactome
R-HSA-74986
(
R-HSA-73772
)
R-HSA-74986
Reaction Name: Elongation of pre-rRNA transcript
See in Reactome
R-HSA-74992
(
R-HSA-73863
)
R-HSA-74992
Reaction Name: Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box
See in Reactome
R-HSA-74993
(
R-HSA-73863
)
R-HSA-74993
Reaction Name: PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box
See in Reactome
R-HSA-74994
(
R-HSA-73863
)
R-HSA-74994
Reaction Name: Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box
See in Reactome
R-HSA-75850
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-75850
Reaction Name: Addition of the third nucleotide on the nascent transcript
See in Reactome
R-HSA-75856
(
R-HSA-674695
)
R-HSA-75856
Reaction Name: Abortive Initiation Before Second Transition
See in Reactome
R-HSA-75861
(
R-HSA-75953;
R-HSA-76042
)
R-HSA-75861
Reaction Name: NTP Binds Active Site of RNA Polymerase II
See in Reactome
R-HSA-75862
(
R-HSA-674695
)
R-HSA-75862
Reaction Name: Fall Back to Closed Pre-initiation Complex
See in Reactome
R-HSA-75864
(
R-HSA-75953;
R-HSA-76042
)
R-HSA-75864
Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released
See in Reactome
R-HSA-75866
(
R-HSA-75953;
R-HSA-76042
)
R-HSA-75866
Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP
See in Reactome
R-HSA-75869
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-75869
Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition
See in Reactome
R-HSA-75873
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-75873
Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript
See in Reactome
R-HSA-75891
(
R-HSA-674695
)
R-HSA-75891
Reaction Name: Abortive Initiation After Second Transition
See in Reactome
R-HSA-75949
(
R-HSA-76042
)
R-HSA-75949
Reaction Name: RNA Polymerase II Promoter Opening: First Transition
See in Reactome
R-HSA-76576
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-76576
Reaction Name: Addition of nucleotides 10 and 11 on the growing transcript: Third Transition
See in Reactome
R-HSA-77068
(
R-HSA-72086;
R-HSA-77075
)
R-HSA-77069
(
R-HSA-72086;
R-HSA-77075
)
R-HSA-77069
Reaction Name: RNA Polymerase II CTD (phosphorylated) binds to CE
See in Reactome
R-HSA-77071
(
R-HSA-77075
)
R-HSA-77071
Reaction Name: Phosphorylation (Ser5) of RNA pol II CTD
See in Reactome
R-HSA-77073
(
R-HSA-72086;
R-HSA-77075
)
R-HSA-77073
Reaction Name: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)
See in Reactome
R-HSA-77077
(
R-HSA-72086
)
R-HSA-77078
(
R-HSA-72086
)
R-HSA-77078
Reaction Name: Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme
See in Reactome
R-HSA-77081
(
R-HSA-72086
)
R-HSA-77081
Reaction Name: Formation of the CE:GMP intermediate complex
See in Reactome
R-HSA-77083
(
R-HSA-72086
)
R-HSA-77083
Reaction Name: Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA
See in Reactome
R-HSA-77085
(
R-HSA-72086
)
R-HSA-77085
Reaction Name: Dissociation of transcript with 5'-GMP from GT
See in Reactome
R-HSA-77090
(
R-HSA-72086
)
R-HSA-77090
Reaction Name: Methylation of GMP-cap by RNA Methyltransferase
See in Reactome
R-HSA-9613494
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-9613494
Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition
See in Reactome
R-HSA-9613497
(
R-HSA-73776;
R-HSA-76042
)
R-HSA-9613497
Reaction Name: Unwinding DNA for the nascent transcript
See in Reactome
R-HSA-9684118
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-9684118
Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER
See in Reactome
|
MONDO:0014696 |
ERCC5 |
P28715 |
3.1.-.-
|
R-HSA-5696400
R-HSA-5696395
R-HSA-5696395
Reactome Name: Formation of Incision Complex in GG-NER
See in Reactome
R-HSA-6782135
|
R-HSA-73894
R-HSA-6781827
R-HSA-6781827
Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER)
See in Reactome
R-HSA-5696398
R-HSA-5696399
R-HSA-5696399
Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER)
See in Reactome
|
DNA Repair
|
R-HSA-5689317
(
R-HSA-5696395
)
R-HSA-5689317
Reaction Name: Formation of the pre-incision complex in GG-NER
See in Reactome
R-HSA-5690213
(
R-HSA-5696400
)
R-HSA-5690213
Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site
See in Reactome
R-HSA-5690988
(
R-HSA-5696400
)
R-HSA-5690988
Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER
See in Reactome
R-HSA-5690990
(
R-HSA-5696400
)
R-HSA-5690990
Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER
See in Reactome
R-HSA-5690991
(
R-HSA-5696395
)
R-HSA-5690991
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER
See in Reactome
R-HSA-6782138
(
R-HSA-6782135
)
R-HSA-6782138
Reaction Name: ERCC5 and RPA bind TC-NER site
See in Reactome
R-HSA-6782141
(
R-HSA-6782135
)
R-HSA-6782141
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
See in Reactome
R-HSA-6782204
(
R-HSA-6782135
)
R-HSA-6782204
Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
See in Reactome
R-HSA-6782211
(
R-HSA-6782135
)
R-HSA-6782211
Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site
See in Reactome
R-HSA-6782224
(
R-HSA-6782135
)
R-HSA-6782224
Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER
See in Reactome
|
MONDO:0019005 |
MONDO:0019005
Disease Name: nephronophthisis
OMIM id: OMIM:615862
Orphanet id: Orphanet:655
All associated enzymes in DAR:
PIAS1
. The disease is also associated to other non-enzyme proteins (not in DAR).
PIAS1 |
O75925 |
2.3.2.-
|
R-HSA-5696395
R-HSA-5696395
Reactome Name: Formation of Incision Complex in GG-NER
See in Reactome
R-HSA-3232118
R-HSA-3232118
Reactome Name: SUMOylation of transcription factors
See in Reactome
R-HSA-3232142
R-HSA-3232142
Reactome Name: SUMOylation of ubiquitinylation proteins
See in Reactome
R-HSA-3899300
R-HSA-3899300
Reactome Name: SUMOylation of transcription cofactors
See in Reactome
R-HSA-4551638
R-HSA-4551638
Reactome Name: SUMOylation of chromatin organization proteins
See in Reactome
R-HSA-877312
R-HSA-3108214
R-HSA-3108214
Reactome Name: SUMOylation of DNA damage response and repair proteins
See in Reactome
R-HSA-4090294
R-HSA-4090294
Reactome Name: SUMOylation of intracellular receptors
See in Reactome
|
R-HSA-3108232
R-HSA-3108232
Reactome Name: SUMO E3 ligases SUMOylate target proteins
See in Reactome
R-HSA-5696398
R-HSA-168256
R-HSA-392499
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-913531
R-HSA-877300
R-HSA-2990846
R-HSA-73894
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5696399
R-HSA-5696399
Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER)
See in Reactome
|
Immune System
Metabolism of proteins
DNA Repair
|
R-HSA-2997616
(
R-HSA-3108214
)
R-HSA-2997616
Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO2,3
See in Reactome
R-HSA-2997709
(
R-HSA-3108214
)
R-HSA-2997709
Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO1
See in Reactome
R-HSA-3000434
(
R-HSA-3232142
)
R-HSA-3000434
Reaction Name: PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1
See in Reactome
R-HSA-3247493
(
R-HSA-3232118
)
R-HSA-3247493
Reaction Name: PIAS1 SUMOylates SP3 with SUMO1
See in Reactome
R-HSA-3465545
(
R-HSA-3232118
)
R-HSA-3465545
Reaction Name: PIAS1,3,4 SUMOylate MTA1 with SUMO2,3
See in Reactome
R-HSA-3900194
(
R-HSA-3899300
)
R-HSA-3900194
Reaction Name: PIAS1 SUMOylates DDX5 with SUMO2
See in Reactome
R-HSA-3968414
(
R-HSA-3232118
)
R-HSA-3968414
Reaction Name: UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1
See in Reactome
R-HSA-4085347
(
R-HSA-3899300
)
R-HSA-4085347
Reaction Name: PIAS1 SUMOylates SAFB with SUMO1
See in Reactome
R-HSA-4085372
(
R-HSA-3899300
)
R-HSA-4085372
Reaction Name: PIAS1 SUMOylates SAFB with SUMO2,3
See in Reactome
R-HSA-4086036
(
R-HSA-3899300
)
R-HSA-4086036
Reaction Name: PIAS1,3 SUMOylate NRIP1 with SUMO1
See in Reactome
R-HSA-4090281
(
R-HSA-3232118
)
R-HSA-4090281
Reaction Name: PIAS1,2-1 SUMOylate HIC1 with SUMO1
See in Reactome
R-HSA-4090288
(
R-HSA-3899300
)
R-HSA-4090288
Reaction Name: PIAS1,3 SUMOylate MBD1 with SUMO1
See in Reactome
R-HSA-4090390
(
R-HSA-4090294
)
R-HSA-4090390
Reaction Name: PIAS1,2-1 SUMOylates AR with SUMO1
See in Reactome
R-HSA-4090408
(
R-HSA-4090294
)
R-HSA-4090408
Reaction Name: PIAS1,3 SUMOylate ESR1 with SUMO1
See in Reactome
R-HSA-4341016
(
R-HSA-4090294
)
R-HSA-4341016
Reaction Name: PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1
See in Reactome
R-HSA-4546385
(
R-HSA-4090294
)
R-HSA-4546385
Reaction Name: PIAS1,3 SUMOylates NR5A1 with SUMO2
See in Reactome
R-HSA-4546386
(
R-HSA-4090294
)
R-HSA-4546386
Reaction Name: PIAS1,3 SUMOylates NR5A1 with SUMO1
See in Reactome
R-HSA-4568848
(
R-HSA-3108214
)
R-HSA-4568848
Reaction Name: PIAS1,2-1 SUMOylates XRCC4 with SUMO1
See in Reactome
R-HSA-4615839
(
R-HSA-4551638
)
R-HSA-4615839
Reaction Name: PIAS1 SUMOylates SATB1 with SUMO2,3
See in Reactome
R-HSA-4615900
(
R-HSA-4551638
)
R-HSA-4615900
Reaction Name: PIAS1 SUMOylates SATB2 with SUMO3
See in Reactome
R-HSA-4615905
(
R-HSA-4551638
)
R-HSA-4615905
Reaction Name: PIAS1 SUMOylates SATB1 with SUMO1
See in Reactome
R-HSA-4717461
(
R-HSA-4090294
)
R-HSA-4717461
Reaction Name: PIAS1,2-2 SUMOylate PPARG with SUMO1
See in Reactome
R-HSA-4717521
(
R-HSA-4090294
)
R-HSA-4719424
(
R-HSA-4090294
)
R-HSA-4719424
Reaction Name: PIAS1 SUMOylates THRB with SUMO1.
See in Reactome
R-HSA-4719448
(
R-HSA-4090294
)
R-HSA-4719448
Reaction Name: PIAS1 SUMOylates THRB with SUMO3
See in Reactome
R-HSA-4755494
(
R-HSA-4090294
)
R-HSA-4755494
Reaction Name: PIAS1,2-1 SUMOylate NR5A2 with SUMO1
See in Reactome
R-HSA-5228521
(
R-HSA-3899300
)
R-HSA-5228521
Reaction Name: PIAS1,4 SUMOylate CASP8AP2 with SUMO1
See in Reactome
R-HSA-6790454
(
R-HSA-5696395
)
R-HSA-6804468
(
R-HSA-3232118
)
R-HSA-6804468
Reaction Name: PIAS1 SUMOylates SP3 with SUMO2
See in Reactome
R-HSA-6804485
(
R-HSA-4551638
)
R-HSA-6804485
Reaction Name: PIAS1 SUMOylates L3MBTL2 with SUMO2
See in Reactome
R-HSA-877281
(
R-HSA-877312
)
|
MONDO:0019569 |
ERCC4 |
Q92889 |
3.1.-.-
|
R-HSA-5696400
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-6783310
R-HSA-5696395
R-HSA-5696395
Reactome Name: Formation of Incision Complex in GG-NER
See in Reactome
R-HSA-6782135
|
R-HSA-5696399
R-HSA-5696399
Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER)
See in Reactome
R-HSA-5696398
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-5693538
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-6781827
R-HSA-6781827
Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER)
See in Reactome
|
DNA Repair
|
R-HSA-109955
(
R-HSA-5696395
)
R-HSA-109955
Reaction Name: Formation of ERCC1:XPF heterodimeric complex
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5690213
(
R-HSA-5696400
)
R-HSA-5690213
Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site
See in Reactome
R-HSA-5690988
(
R-HSA-5696400
)
R-HSA-5690988
Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER
See in Reactome
R-HSA-5690990
(
R-HSA-5696400
)
R-HSA-5690990
Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER
See in Reactome
R-HSA-5690991
(
R-HSA-5696395
)
R-HSA-5690991
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER
See in Reactome
R-HSA-6782141
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782141
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
See in Reactome
R-HSA-6782204
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782204
Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
See in Reactome
R-HSA-6782211
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782211
Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site
See in Reactome
R-HSA-6782224
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782224
Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER
See in Reactome
R-HSA-6785732
(
R-HSA-6783310
)
R-HSA-6785732
Reaction Name: DNA nucleases bind monoubiquitinated ID2 complex
See in Reactome
R-HSA-6785986
(
R-HSA-6783310
)
R-HSA-6785986
Reaction Name: DNA nucleases unhook the interstrand crosslink (ICL)
See in Reactome
|
MONDO:0032794 |
USP45 |
Q70EL2 |
3.4.19.12
|
R-HSA-5696395
R-HSA-5696395
Reactome Name: Formation of Incision Complex in GG-NER
See in Reactome
|
R-HSA-73894
R-HSA-5696399
R-HSA-5696399
Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER)
See in Reactome
R-HSA-5696398
|
DNA Repair
|
R-HSA-5696465
(
R-HSA-5696395
)
|