MONDO:0005036 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0005061 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0005335 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0005595 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0007088 |
VCP |
P55072 |
3.6.4.6
|
R-HSA-3371511
R-HSA-9646399
R-HSA-110320
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5358346
R-HSA-9013407
R-HSA-532668
R-HSA-532668
Reactome Name: N-glycan trimming in the ER and Calnexin/Calreticulin cycle
See in Reactome
R-HSA-6798695
R-HSA-8876725
R-HSA-8866654
R-HSA-8866654
Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins
See in Reactome
R-HSA-5689877
|
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-382551
R-HSA-5358351
R-HSA-8953897
R-HSA-2262752
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-9612973
R-HSA-168249
R-HSA-9663891
R-HSA-392499
R-HSA-110313
R-HSA-110313
Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
See in Reactome
R-HSA-8852135
R-HSA-1632852
R-HSA-5688426
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-73894
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-162582
R-HSA-73893
|
Immune System
Transport of small molecules
Cellular responses to stimuli
Autophagy
Metabolism of proteins
DNA Repair
Signal Transduction
|
R-HSA-5324632
(
R-HSA-3371511
)
R-HSA-5324632
Reaction Name: Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates
See in Reactome
R-HSA-5362412
(
R-HSA-5358346
)
R-HSA-5362412
Reaction Name: SYVN1 ubiquitinates Hh C-terminal fragments
See in Reactome
R-HSA-5362441
(
R-HSA-5358346
)
R-HSA-5362441
Reaction Name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane
See in Reactome
R-HSA-5362459
(
R-HSA-5358346
)
R-HSA-5362459
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol
See in Reactome
R-HSA-5654985
(
R-HSA-110320
)
R-HSA-5654985
Reaction Name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH
See in Reactome
R-HSA-5654989
(
R-HSA-110320
)
R-HSA-5654989
Reaction Name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA
See in Reactome
R-HSA-5688834
(
R-HSA-5689877
)
R-HSA-6781953
(
R-HSA-5689896
)
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-8850594
(
R-HSA-532668
)
R-HSA-8850594
Reaction Name: Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins
See in Reactome
R-HSA-8866542
(
R-HSA-382556
)
R-HSA-8866542
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol
See in Reactome
R-HSA-8866546
(
R-HSA-382556
)
R-HSA-8866546
Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR
See in Reactome
R-HSA-8866551
(
R-HSA-382556
)
R-HSA-8866551
Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation
See in Reactome
R-HSA-8932276
(
R-HSA-8876725
)
R-HSA-8932276
Reaction Name: VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP
See in Reactome
R-HSA-8943080
(
R-HSA-8866654
)
R-HSA-8943080
Reaction Name: TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11
See in Reactome
R-HSA-8943083
(
R-HSA-8866654
)
R-HSA-8943083
Reaction Name: US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9646347
(
R-HSA-9646399
)
R-HSA-9646347
Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1
See in Reactome
R-HSA-9646354
(
R-HSA-9646399
)
R-HSA-9646354
Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex
See in Reactome
R-HSA-9755507
()
R-HSA-9755507
Reaction Name: UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex
See in Reactome
R-HSA-9758088
()
R-HSA-9758088
Reaction Name: UBXN7 binds VCP hexamer:UBF1:NPLOC4
See in Reactome
R-HSA-9758090
()
R-HSA-9758090
Reaction Name: Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation
See in Reactome
|
MONDO:0007774 |
MONDO:0007774
Disease Name: hyperreflexia
OMIM id: OMIM:145290
All associated enzymes in DAR:
IFIH1
. The disease is also associated to other non-enzyme proteins (not in DAR).
IFIH1 |
Q9BYX4 |
3.6.4.13
|
R-HSA-933542
R-HSA-933542
Reactome Name: TRAF6 mediated NF-kB activation
See in Reactome
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-933541
R-HSA-918233
R-HSA-918233
Reactome Name: TRAF3-dependent IRF activation pathway
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-936440
R-HSA-936440
Reactome Name: Negative regulators of DDX58/IFIH1 signaling
See in Reactome
|
R-HSA-168256
R-HSA-168249
R-HSA-5688426
R-HSA-392499
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
|
Immune System
Metabolism of proteins
|
R-HSA-168909
(
R-HSA-168928
)
R-HSA-168909
Reaction Name: viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS
See in Reactome
R-HSA-168934
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-168934
Reaction Name: MAVS interacts with RIPK1 and FADD
See in Reactome
R-HSA-5696600
(
R-HSA-5689880
)
R-HSA-5696600
Reaction Name: USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1
See in Reactome
R-HSA-913725
(
R-HSA-168928
)
R-HSA-918225
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918225
Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3
See in Reactome
R-HSA-918227
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918229
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918229
Reaction Name: Phosphorylation and release of IRF3/IRF7
See in Reactome
R-HSA-918230
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-918230
Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1
See in Reactome
R-HSA-918232
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-933523
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933523
Reaction Name: Dimerzation of procaspase-8, procaspase-10
See in Reactome
R-HSA-933525
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933525
Reaction Name: Phosphorylation and release of IRF7
See in Reactome
R-HSA-933526
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933526
Reaction Name: Recruitment of caspase-8 and -10 to FADD complex
See in Reactome
R-HSA-933527
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933527
Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6
See in Reactome
R-HSA-933528
(
R-HSA-168928;
R-HSA-933542
)
R-HSA-933528
Reaction Name: Interaction of MEKK1 with TRAF6
See in Reactome
R-HSA-933530
(
R-HSA-168928;
R-HSA-933542
)
R-HSA-933532
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933537
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933538
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933539
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-936378
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-936378
Reaction Name: Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS
See in Reactome
R-HSA-936381
(
R-HSA-168928;
R-HSA-5689896;
R-HSA-936440
)
R-HSA-936412
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-936412
Reaction Name: RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS
See in Reactome
R-HSA-936475
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-936475
Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216
See in Reactome
R-HSA-937343
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-937343
Reaction Name: NLRC5 interacts with DDX58/IFIH1
See in Reactome
R-HSA-9705137
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-9705137
Reaction Name: TBK1 or IKBKE forms homodimers
See in Reactome
R-HSA-9705145
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-9705320
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-9705320
Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172
See in Reactome
R-HSA-9705323
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-990526
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-990526
Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS
See in Reactome
R-HSA-990528
(
R-HSA-168928;
R-HSA-936440
)
|
MONDO:0007924 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0008021 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0008170 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0008178 |
VCP |
P55072 |
3.6.4.6
|
R-HSA-3371511
R-HSA-9646399
R-HSA-110320
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5358346
R-HSA-9013407
R-HSA-532668
R-HSA-532668
Reactome Name: N-glycan trimming in the ER and Calnexin/Calreticulin cycle
See in Reactome
R-HSA-6798695
R-HSA-8876725
R-HSA-8866654
R-HSA-8866654
Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins
See in Reactome
R-HSA-5689877
|
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-382551
R-HSA-5358351
R-HSA-8953897
R-HSA-2262752
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-9612973
R-HSA-168249
R-HSA-9663891
R-HSA-392499
R-HSA-110313
R-HSA-110313
Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
See in Reactome
R-HSA-8852135
R-HSA-1632852
R-HSA-5688426
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-73894
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-162582
R-HSA-73893
|
Immune System
Transport of small molecules
Cellular responses to stimuli
Autophagy
Metabolism of proteins
DNA Repair
Signal Transduction
|
R-HSA-5324632
(
R-HSA-3371511
)
R-HSA-5324632
Reaction Name: Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates
See in Reactome
R-HSA-5362412
(
R-HSA-5358346
)
R-HSA-5362412
Reaction Name: SYVN1 ubiquitinates Hh C-terminal fragments
See in Reactome
R-HSA-5362441
(
R-HSA-5358346
)
R-HSA-5362441
Reaction Name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane
See in Reactome
R-HSA-5362459
(
R-HSA-5358346
)
R-HSA-5362459
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol
See in Reactome
R-HSA-5654985
(
R-HSA-110320
)
R-HSA-5654985
Reaction Name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH
See in Reactome
R-HSA-5654989
(
R-HSA-110320
)
R-HSA-5654989
Reaction Name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA
See in Reactome
R-HSA-5688834
(
R-HSA-5689877
)
R-HSA-6781953
(
R-HSA-5689896
)
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-8850594
(
R-HSA-532668
)
R-HSA-8850594
Reaction Name: Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins
See in Reactome
R-HSA-8866542
(
R-HSA-382556
)
R-HSA-8866542
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol
See in Reactome
R-HSA-8866546
(
R-HSA-382556
)
R-HSA-8866546
Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR
See in Reactome
R-HSA-8866551
(
R-HSA-382556
)
R-HSA-8866551
Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation
See in Reactome
R-HSA-8932276
(
R-HSA-8876725
)
R-HSA-8932276
Reaction Name: VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP
See in Reactome
R-HSA-8943080
(
R-HSA-8866654
)
R-HSA-8943080
Reaction Name: TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11
See in Reactome
R-HSA-8943083
(
R-HSA-8866654
)
R-HSA-8943083
Reaction Name: US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9646347
(
R-HSA-9646399
)
R-HSA-9646347
Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1
See in Reactome
R-HSA-9646354
(
R-HSA-9646399
)
R-HSA-9646354
Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex
See in Reactome
R-HSA-9755507
()
R-HSA-9755507
Reaction Name: UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex
See in Reactome
R-HSA-9758088
()
R-HSA-9758088
Reaction Name: UBXN7 binds VCP hexamer:UBF1:NPLOC4
See in Reactome
R-HSA-9758090
()
R-HSA-9758090
Reaction Name: Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation
See in Reactome
|
MONDO:0008318 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0010150 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0010172 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0011537 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0011738 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0011789 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0011951 |
VCP |
P55072 |
3.6.4.6
|
R-HSA-3371511
R-HSA-9646399
R-HSA-110320
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5358346
R-HSA-9013407
R-HSA-532668
R-HSA-532668
Reactome Name: N-glycan trimming in the ER and Calnexin/Calreticulin cycle
See in Reactome
R-HSA-6798695
R-HSA-8876725
R-HSA-8866654
R-HSA-8866654
Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins
See in Reactome
R-HSA-5689877
|
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-382551
R-HSA-5358351
R-HSA-8953897
R-HSA-2262752
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-9612973
R-HSA-168249
R-HSA-9663891
R-HSA-392499
R-HSA-110313
R-HSA-110313
Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
See in Reactome
R-HSA-8852135
R-HSA-1632852
R-HSA-5688426
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-73894
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-162582
R-HSA-73893
|
Immune System
Transport of small molecules
Cellular responses to stimuli
Autophagy
Metabolism of proteins
DNA Repair
Signal Transduction
|
R-HSA-5324632
(
R-HSA-3371511
)
R-HSA-5324632
Reaction Name: Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates
See in Reactome
R-HSA-5362412
(
R-HSA-5358346
)
R-HSA-5362412
Reaction Name: SYVN1 ubiquitinates Hh C-terminal fragments
See in Reactome
R-HSA-5362441
(
R-HSA-5358346
)
R-HSA-5362441
Reaction Name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane
See in Reactome
R-HSA-5362459
(
R-HSA-5358346
)
R-HSA-5362459
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol
See in Reactome
R-HSA-5654985
(
R-HSA-110320
)
R-HSA-5654985
Reaction Name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH
See in Reactome
R-HSA-5654989
(
R-HSA-110320
)
R-HSA-5654989
Reaction Name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA
See in Reactome
R-HSA-5688834
(
R-HSA-5689877
)
R-HSA-6781953
(
R-HSA-5689896
)
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-8850594
(
R-HSA-532668
)
R-HSA-8850594
Reaction Name: Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins
See in Reactome
R-HSA-8866542
(
R-HSA-382556
)
R-HSA-8866542
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol
See in Reactome
R-HSA-8866546
(
R-HSA-382556
)
R-HSA-8866546
Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR
See in Reactome
R-HSA-8866551
(
R-HSA-382556
)
R-HSA-8866551
Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation
See in Reactome
R-HSA-8932276
(
R-HSA-8876725
)
R-HSA-8932276
Reaction Name: VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP
See in Reactome
R-HSA-8943080
(
R-HSA-8866654
)
R-HSA-8943080
Reaction Name: TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11
See in Reactome
R-HSA-8943083
(
R-HSA-8866654
)
R-HSA-8943083
Reaction Name: US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9646347
(
R-HSA-9646399
)
R-HSA-9646347
Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1
See in Reactome
R-HSA-9646354
(
R-HSA-9646399
)
R-HSA-9646354
Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex
See in Reactome
R-HSA-9755507
()
R-HSA-9755507
Reaction Name: UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex
See in Reactome
R-HSA-9758088
()
R-HSA-9758088
Reaction Name: UBXN7 binds VCP hexamer:UBF1:NPLOC4
See in Reactome
R-HSA-9758090
()
R-HSA-9758090
Reaction Name: Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation
See in Reactome
|
MONDO:0011962 |
MONDO:0011962
Disease Name: endometrial cancer
OMIM id: OMIM:608089
All associated enzymes in DAR:
PTEN
. The disease is also associated to other non-enzyme proteins (not in DAR).
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0012422 |
IFIH1 |
Q9BYX4 |
3.6.4.13
|
R-HSA-933542
R-HSA-933542
Reactome Name: TRAF6 mediated NF-kB activation
See in Reactome
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-933541
R-HSA-918233
R-HSA-918233
Reactome Name: TRAF3-dependent IRF activation pathway
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-936440
R-HSA-936440
Reactome Name: Negative regulators of DDX58/IFIH1 signaling
See in Reactome
|
R-HSA-168256
R-HSA-168249
R-HSA-5688426
R-HSA-392499
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
|
Immune System
Metabolism of proteins
|
R-HSA-168909
(
R-HSA-168928
)
R-HSA-168909
Reaction Name: viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS
See in Reactome
R-HSA-168934
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-168934
Reaction Name: MAVS interacts with RIPK1 and FADD
See in Reactome
R-HSA-5696600
(
R-HSA-5689880
)
R-HSA-5696600
Reaction Name: USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1
See in Reactome
R-HSA-913725
(
R-HSA-168928
)
R-HSA-918225
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918225
Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3
See in Reactome
R-HSA-918227
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918229
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918229
Reaction Name: Phosphorylation and release of IRF3/IRF7
See in Reactome
R-HSA-918230
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-918230
Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1
See in Reactome
R-HSA-918232
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-933523
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933523
Reaction Name: Dimerzation of procaspase-8, procaspase-10
See in Reactome
R-HSA-933525
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933525
Reaction Name: Phosphorylation and release of IRF7
See in Reactome
R-HSA-933526
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933526
Reaction Name: Recruitment of caspase-8 and -10 to FADD complex
See in Reactome
R-HSA-933527
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933527
Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6
See in Reactome
R-HSA-933528
(
R-HSA-168928;
R-HSA-933542
)
R-HSA-933528
Reaction Name: Interaction of MEKK1 with TRAF6
See in Reactome
R-HSA-933530
(
R-HSA-168928;
R-HSA-933542
)
R-HSA-933532
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933537
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933538
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933539
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-936378
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-936378
Reaction Name: Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS
See in Reactome
R-HSA-936381
(
R-HSA-168928;
R-HSA-5689896;
R-HSA-936440
)
R-HSA-936412
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-936412
Reaction Name: RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS
See in Reactome
R-HSA-936475
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-936475
Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216
See in Reactome
R-HSA-937343
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-937343
Reaction Name: NLRC5 interacts with DDX58/IFIH1
See in Reactome
R-HSA-9705137
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-9705137
Reaction Name: TBK1 or IKBKE forms homodimers
See in Reactome
R-HSA-9705145
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-9705320
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-9705320
Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172
See in Reactome
R-HSA-9705323
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-990526
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-990526
Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS
See in Reactome
R-HSA-990528
(
R-HSA-168928;
R-HSA-936440
)
|
MONDO:0013092 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0013501 |
VCP |
P55072 |
3.6.4.6
|
R-HSA-3371511
R-HSA-9646399
R-HSA-110320
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5358346
R-HSA-9013407
R-HSA-532668
R-HSA-532668
Reactome Name: N-glycan trimming in the ER and Calnexin/Calreticulin cycle
See in Reactome
R-HSA-6798695
R-HSA-8876725
R-HSA-8866654
R-HSA-8866654
Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins
See in Reactome
R-HSA-5689877
|
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-382551
R-HSA-5358351
R-HSA-8953897
R-HSA-2262752
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-9612973
R-HSA-168249
R-HSA-9663891
R-HSA-392499
R-HSA-110313
R-HSA-110313
Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
See in Reactome
R-HSA-8852135
R-HSA-1632852
R-HSA-5688426
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-73894
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-162582
R-HSA-73893
|
Immune System
Transport of small molecules
Cellular responses to stimuli
Autophagy
Metabolism of proteins
DNA Repair
Signal Transduction
|
R-HSA-5324632
(
R-HSA-3371511
)
R-HSA-5324632
Reaction Name: Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates
See in Reactome
R-HSA-5362412
(
R-HSA-5358346
)
R-HSA-5362412
Reaction Name: SYVN1 ubiquitinates Hh C-terminal fragments
See in Reactome
R-HSA-5362441
(
R-HSA-5358346
)
R-HSA-5362441
Reaction Name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane
See in Reactome
R-HSA-5362459
(
R-HSA-5358346
)
R-HSA-5362459
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol
See in Reactome
R-HSA-5654985
(
R-HSA-110320
)
R-HSA-5654985
Reaction Name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH
See in Reactome
R-HSA-5654989
(
R-HSA-110320
)
R-HSA-5654989
Reaction Name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA
See in Reactome
R-HSA-5688834
(
R-HSA-5689877
)
R-HSA-6781953
(
R-HSA-5689896
)
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-8850594
(
R-HSA-532668
)
R-HSA-8850594
Reaction Name: Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins
See in Reactome
R-HSA-8866542
(
R-HSA-382556
)
R-HSA-8866542
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol
See in Reactome
R-HSA-8866546
(
R-HSA-382556
)
R-HSA-8866546
Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR
See in Reactome
R-HSA-8866551
(
R-HSA-382556
)
R-HSA-8866551
Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation
See in Reactome
R-HSA-8932276
(
R-HSA-8876725
)
R-HSA-8932276
Reaction Name: VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP
See in Reactome
R-HSA-8943080
(
R-HSA-8866654
)
R-HSA-8943080
Reaction Name: TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11
See in Reactome
R-HSA-8943083
(
R-HSA-8866654
)
R-HSA-8943083
Reaction Name: US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9646347
(
R-HSA-9646399
)
R-HSA-9646347
Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1
See in Reactome
R-HSA-9646354
(
R-HSA-9646399
)
R-HSA-9646354
Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex
See in Reactome
R-HSA-9755507
()
R-HSA-9755507
Reaction Name: UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex
See in Reactome
R-HSA-9758088
()
R-HSA-9758088
Reaction Name: UBXN7 binds VCP hexamer:UBF1:NPLOC4
See in Reactome
R-HSA-9758090
()
R-HSA-9758090
Reaction Name: Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation
See in Reactome
|
MONDO:0013617 |
RNF135 |
Q8IUD6 |
2.3.2.27
|
R-HSA-933542
R-HSA-933542
Reactome Name: TRAF6 mediated NF-kB activation
See in Reactome
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-933541
R-HSA-918233
R-HSA-918233
Reactome Name: TRAF3-dependent IRF activation pathway
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-936440
R-HSA-936440
Reactome Name: Negative regulators of DDX58/IFIH1 signaling
See in Reactome
|
R-HSA-168256
R-HSA-168249
R-HSA-5688426
R-HSA-392499
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
|
Immune System
Metabolism of proteins
|
R-HSA-168909
(
R-HSA-168928
)
R-HSA-168909
Reaction Name: viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS
See in Reactome
R-HSA-168934
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-168934
Reaction Name: MAVS interacts with RIPK1 and FADD
See in Reactome
R-HSA-918224
(
R-HSA-168928
)
R-HSA-918225
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918225
Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3
See in Reactome
R-HSA-918227
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918229
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918229
Reaction Name: Phosphorylation and release of IRF3/IRF7
See in Reactome
R-HSA-918230
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-918230
Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1
See in Reactome
R-HSA-918232
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-933523
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933523
Reaction Name: Dimerzation of procaspase-8, procaspase-10
See in Reactome
R-HSA-933525
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933525
Reaction Name: Phosphorylation and release of IRF7
See in Reactome
R-HSA-933526
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933526
Reaction Name: Recruitment of caspase-8 and -10 to FADD complex
See in Reactome
R-HSA-933527
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933527
Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6
See in Reactome
R-HSA-933528
(
R-HSA-168928;
R-HSA-933542
)
R-HSA-933528
Reaction Name: Interaction of MEKK1 with TRAF6
See in Reactome
R-HSA-933530
(
R-HSA-168928;
R-HSA-933542
)
R-HSA-933532
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933537
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933538
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933539
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-936378
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-936378
Reaction Name: Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS
See in Reactome
R-HSA-936381
(
R-HSA-168928;
R-HSA-5689896;
R-HSA-936440
)
R-HSA-936475
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-936475
Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216
See in Reactome
R-HSA-937343
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-937343
Reaction Name: NLRC5 interacts with DDX58/IFIH1
See in Reactome
R-HSA-9705137
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-9705137
Reaction Name: TBK1 or IKBKE forms homodimers
See in Reactome
R-HSA-9705145
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-9705320
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-9705320
Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172
See in Reactome
R-HSA-9705323
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-990526
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-990526
Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS
See in Reactome
R-HSA-990528
(
R-HSA-168928;
R-HSA-936440
)
|
MONDO:0013920 |
TRAF3 |
Q13114 |
2.3.2.27
|
R-HSA-9013973
R-HSA-9013973
Reactome Name: TICAM1-dependent activation of IRF3/IRF7
See in Reactome
R-HSA-5668541
R-HSA-5668541
Reactome Name: TNFR2 non-canonical NF-kB pathway
See in Reactome
R-HSA-918233
R-HSA-918233
Reactome Name: TRAF3-dependent IRF activation pathway
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-936440
R-HSA-936440
Reactome Name: Negative regulators of DDX58/IFIH1 signaling
See in Reactome
R-HSA-5676594
R-HSA-5676594
Reactome Name: TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
See in Reactome
R-HSA-936964
R-HSA-936964
Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-168256
R-HSA-168249
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-392499
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168898
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-5688426
R-HSA-166166
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
|
Immune System
Metabolism of proteins
|
R-HSA-166245
(
R-HSA-936964
)
R-HSA-166245
Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex
See in Reactome
R-HSA-166271
(
R-HSA-936964
)
R-HSA-166271
Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
See in Reactome
R-HSA-2201338
(
R-HSA-936964
)
R-HSA-2201338
Reaction Name: TRAF3 binds TICAM1:activated TLR4 complex
See in Reactome
R-HSA-2213017
(
R-HSA-936964
)
R-HSA-5362486
(
R-HSA-936964
)
R-HSA-5362486
Reaction Name: TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4
See in Reactome
R-HSA-5362500
(
R-HSA-936964
)
R-HSA-5362500
Reaction Name: TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4
See in Reactome
R-HSA-5668414
(
R-HSA-5668541
)
R-HSA-5668414
Reaction Name: TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK
See in Reactome
R-HSA-5668417
(
R-HSA-5668541
)
R-HSA-5668417
Reaction Name: cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer
See in Reactome
R-HSA-5668454
(
R-HSA-5668541
)
R-HSA-5668454
Reaction Name: K63polyUb-cIAP1,2 ubiquitinates TRAF3
See in Reactome
R-HSA-5668481
(
R-HSA-5668541
)
R-HSA-5668481
Reaction Name: Protesomal degradation of K48polyUb-TRAF3
See in Reactome
R-HSA-5668534
(
R-HSA-5668541
)
R-HSA-5668534
Reaction Name: cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK
See in Reactome
R-HSA-5668543
(
R-HSA-5668541
)
R-HSA-5676593
(
R-HSA-5668541;
R-HSA-5676594
)
R-HSA-5676593
Reaction Name: TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR
See in Reactome
R-HSA-5676595
(
R-HSA-5668541;
R-HSA-5676594
)
R-HSA-5676596
(
R-HSA-5668541;
R-HSA-5676594
)
R-HSA-5676597
(
R-HSA-5668541;
R-HSA-5676594
)
R-HSA-5676597
Reaction Name: TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40
See in Reactome
R-HSA-5676598
(
R-HSA-5668541;
R-HSA-5676594
)
R-HSA-5676598
Reaction Name: TRAF2:cIAP1/2 complex binds FN14:TWEAK
See in Reactome
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-9013974
(
R-HSA-9013973
)
R-HSA-9013974
Reaction Name: Auto-ubiquitination of TRAF3 within activated TLR3 complex
See in Reactome
R-HSA-9013978
(
R-HSA-9013973
)
R-HSA-9013978
Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex
See in Reactome
R-HSA-9013979
(
R-HSA-9013973
)
R-HSA-9013979
Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3
See in Reactome
R-HSA-9013985
(
R-HSA-9013973
)
R-HSA-9013985
Reaction Name: TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3
See in Reactome
R-HSA-9013986
(
R-HSA-9013973
)
R-HSA-9013986
Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation
See in Reactome
R-HSA-9013990
(
R-HSA-9013973
)
R-HSA-9013990
Reaction Name: TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA
See in Reactome
R-HSA-9013992
(
R-HSA-9013973
)
R-HSA-9013992
Reaction Name: TRAF3 binds to TRIF:activated TLR3 complex
See in Reactome
R-HSA-918225
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918225
Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3
See in Reactome
R-HSA-918227
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918229
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918229
Reaction Name: Phosphorylation and release of IRF3/IRF7
See in Reactome
R-HSA-918232
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-936381
(
R-HSA-168928;
R-HSA-5689896;
R-HSA-936440
)
R-HSA-936475
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-936475
Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216
See in Reactome
R-HSA-936941
(
R-HSA-936964
)
R-HSA-936941
Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation
See in Reactome
R-HSA-9705137
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-9705137
Reaction Name: TBK1 or IKBKE forms homodimers
See in Reactome
R-HSA-9705320
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-9705320
Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172
See in Reactome
|
MONDO:0014367 |
IFIH1 |
Q9BYX4 |
3.6.4.13
|
R-HSA-933542
R-HSA-933542
Reactome Name: TRAF6 mediated NF-kB activation
See in Reactome
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-933541
R-HSA-918233
R-HSA-918233
Reactome Name: TRAF3-dependent IRF activation pathway
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-936440
R-HSA-936440
Reactome Name: Negative regulators of DDX58/IFIH1 signaling
See in Reactome
|
R-HSA-168256
R-HSA-168249
R-HSA-5688426
R-HSA-392499
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
|
Immune System
Metabolism of proteins
|
R-HSA-168909
(
R-HSA-168928
)
R-HSA-168909
Reaction Name: viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS
See in Reactome
R-HSA-168934
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-168934
Reaction Name: MAVS interacts with RIPK1 and FADD
See in Reactome
R-HSA-5696600
(
R-HSA-5689880
)
R-HSA-5696600
Reaction Name: USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1
See in Reactome
R-HSA-913725
(
R-HSA-168928
)
R-HSA-918225
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918225
Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3
See in Reactome
R-HSA-918227
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918229
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918229
Reaction Name: Phosphorylation and release of IRF3/IRF7
See in Reactome
R-HSA-918230
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-918230
Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1
See in Reactome
R-HSA-918232
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-933523
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933523
Reaction Name: Dimerzation of procaspase-8, procaspase-10
See in Reactome
R-HSA-933525
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933525
Reaction Name: Phosphorylation and release of IRF7
See in Reactome
R-HSA-933526
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933526
Reaction Name: Recruitment of caspase-8 and -10 to FADD complex
See in Reactome
R-HSA-933527
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933527
Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6
See in Reactome
R-HSA-933528
(
R-HSA-168928;
R-HSA-933542
)
R-HSA-933528
Reaction Name: Interaction of MEKK1 with TRAF6
See in Reactome
R-HSA-933530
(
R-HSA-168928;
R-HSA-933542
)
R-HSA-933532
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933537
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933538
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933539
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-936378
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-936378
Reaction Name: Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS
See in Reactome
R-HSA-936381
(
R-HSA-168928;
R-HSA-5689896;
R-HSA-936440
)
R-HSA-936412
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-936412
Reaction Name: RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS
See in Reactome
R-HSA-936475
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-936475
Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216
See in Reactome
R-HSA-937343
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-937343
Reaction Name: NLRC5 interacts with DDX58/IFIH1
See in Reactome
R-HSA-9705137
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-9705137
Reaction Name: TBK1 or IKBKE forms homodimers
See in Reactome
R-HSA-9705145
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-9705320
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-9705320
Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172
See in Reactome
R-HSA-9705323
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-990526
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-990526
Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS
See in Reactome
R-HSA-990528
(
R-HSA-168928;
R-HSA-936440
)
|
MONDO:0014575 |
DDX58 |
O95786 |
3.6.4.13
|
R-HSA-933542
R-HSA-933542
Reactome Name: TRAF6 mediated NF-kB activation
See in Reactome
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-933541
R-HSA-918233
R-HSA-918233
Reactome Name: TRAF3-dependent IRF activation pathway
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-1169408
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-936440
R-HSA-936440
Reactome Name: Negative regulators of DDX58/IFIH1 signaling
See in Reactome
R-HSA-8983711
|
R-HSA-5688426
R-HSA-168256
R-HSA-392499
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-168249
R-HSA-913531
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1169410
R-HSA-1169410
Reactome Name: Antiviral mechanism by IFN-stimulated genes
See in Reactome
|
Immune System
Metabolism of proteins
|
R-HSA-1169406
(
R-HSA-1169408
)
R-HSA-1678841
(
R-HSA-1169408
)
R-HSA-1678841
Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18
See in Reactome
R-HSA-168909
(
R-HSA-168928
)
R-HSA-168909
Reaction Name: viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS
See in Reactome
R-HSA-168934
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-168934
Reaction Name: MAVS interacts with RIPK1 and FADD
See in Reactome
R-HSA-168935
(
R-HSA-168928
)
R-HSA-5690159
(
R-HSA-5689880
)
R-HSA-5690159
Reaction Name: USP21 deubiquitinates RIPK1,DDX58
See in Reactome
R-HSA-5696564
(
R-HSA-5689880
)
R-HSA-5696600
(
R-HSA-5689880
)
R-HSA-5696600
Reaction Name: USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1
See in Reactome
R-HSA-8985153
(
R-HSA-8983711
)
R-HSA-918224
(
R-HSA-168928
)
R-HSA-918225
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918225
Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3
See in Reactome
R-HSA-918227
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918229
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918229
Reaction Name: Phosphorylation and release of IRF3/IRF7
See in Reactome
R-HSA-918230
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-918230
Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1
See in Reactome
R-HSA-918232
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-933523
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933523
Reaction Name: Dimerzation of procaspase-8, procaspase-10
See in Reactome
R-HSA-933525
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933525
Reaction Name: Phosphorylation and release of IRF7
See in Reactome
R-HSA-933526
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933526
Reaction Name: Recruitment of caspase-8 and -10 to FADD complex
See in Reactome
R-HSA-933527
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933527
Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6
See in Reactome
R-HSA-933528
(
R-HSA-168928;
R-HSA-933542
)
R-HSA-933528
Reaction Name: Interaction of MEKK1 with TRAF6
See in Reactome
R-HSA-933530
(
R-HSA-168928;
R-HSA-933542
)
R-HSA-933532
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933537
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933538
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933539
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-936378
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-936378
Reaction Name: Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS
See in Reactome
R-HSA-936381
(
R-HSA-168928;
R-HSA-5689896;
R-HSA-936440
)
R-HSA-936390
(
R-HSA-168928;
R-HSA-5689880;
R-HSA-936440
)
R-HSA-936390
Reaction Name: CYLD mediated deubiquitination of DDX58 (RIG-I)
See in Reactome
R-HSA-936412
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-936412
Reaction Name: RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS
See in Reactome
R-HSA-936475
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-936475
Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216
See in Reactome
R-HSA-936563
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-937343
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-937343
Reaction Name: NLRC5 interacts with DDX58/IFIH1
See in Reactome
R-HSA-9705137
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-9705137
Reaction Name: TBK1 or IKBKE forms homodimers
See in Reactome
R-HSA-9705145
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-9705320
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-9705320
Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172
See in Reactome
R-HSA-9705323
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-990526
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-990526
Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS
See in Reactome
R-HSA-990528
(
R-HSA-168928;
R-HSA-936440
)
|
MONDO:0014735 |
VCP |
P55072 |
3.6.4.6
|
R-HSA-3371511
R-HSA-9646399
R-HSA-110320
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5358346
R-HSA-9013407
R-HSA-532668
R-HSA-532668
Reactome Name: N-glycan trimming in the ER and Calnexin/Calreticulin cycle
See in Reactome
R-HSA-6798695
R-HSA-8876725
R-HSA-8866654
R-HSA-8866654
Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins
See in Reactome
R-HSA-5689877
|
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-382551
R-HSA-5358351
R-HSA-8953897
R-HSA-2262752
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-9612973
R-HSA-168249
R-HSA-9663891
R-HSA-392499
R-HSA-110313
R-HSA-110313
Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
See in Reactome
R-HSA-8852135
R-HSA-1632852
R-HSA-5688426
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-73894
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-162582
R-HSA-73893
|
Immune System
Transport of small molecules
Cellular responses to stimuli
Autophagy
Metabolism of proteins
DNA Repair
Signal Transduction
|
R-HSA-5324632
(
R-HSA-3371511
)
R-HSA-5324632
Reaction Name: Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates
See in Reactome
R-HSA-5362412
(
R-HSA-5358346
)
R-HSA-5362412
Reaction Name: SYVN1 ubiquitinates Hh C-terminal fragments
See in Reactome
R-HSA-5362441
(
R-HSA-5358346
)
R-HSA-5362441
Reaction Name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane
See in Reactome
R-HSA-5362459
(
R-HSA-5358346
)
R-HSA-5362459
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol
See in Reactome
R-HSA-5654985
(
R-HSA-110320
)
R-HSA-5654985
Reaction Name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH
See in Reactome
R-HSA-5654989
(
R-HSA-110320
)
R-HSA-5654989
Reaction Name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA
See in Reactome
R-HSA-5688834
(
R-HSA-5689877
)
R-HSA-6781953
(
R-HSA-5689896
)
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-8850594
(
R-HSA-532668
)
R-HSA-8850594
Reaction Name: Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins
See in Reactome
R-HSA-8866542
(
R-HSA-382556
)
R-HSA-8866542
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol
See in Reactome
R-HSA-8866546
(
R-HSA-382556
)
R-HSA-8866546
Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR
See in Reactome
R-HSA-8866551
(
R-HSA-382556
)
R-HSA-8866551
Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation
See in Reactome
R-HSA-8932276
(
R-HSA-8876725
)
R-HSA-8932276
Reaction Name: VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP
See in Reactome
R-HSA-8943080
(
R-HSA-8866654
)
R-HSA-8943080
Reaction Name: TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11
See in Reactome
R-HSA-8943083
(
R-HSA-8866654
)
R-HSA-8943083
Reaction Name: US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9646347
(
R-HSA-9646399
)
R-HSA-9646347
Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1
See in Reactome
R-HSA-9646354
(
R-HSA-9646399
)
R-HSA-9646354
Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex
See in Reactome
R-HSA-9755507
()
R-HSA-9755507
Reaction Name: UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex
See in Reactome
R-HSA-9758088
()
R-HSA-9758088
Reaction Name: UBXN7 binds VCP hexamer:UBF1:NPLOC4
See in Reactome
R-HSA-9758090
()
R-HSA-9758090
Reaction Name: Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation
See in Reactome
|
MONDO:0014761 |
TNFAIP3 |
P21580 |
2.3.2.-
3.4.19.12
|
R-HSA-5357786
R-HSA-5357786
Reactome Name: TNFR1-induced proapoptotic signaling
See in Reactome
R-HSA-168638
R-HSA-5357905
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-936440
R-HSA-936440
Reactome Name: Negative regulators of DDX58/IFIH1 signaling
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
|
R-HSA-5688426
R-HSA-168256
R-HSA-392499
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-73887
R-HSA-75893
R-HSA-168249
R-HSA-162582
|
Immune System
Metabolism of proteins
Signal Transduction
|
R-HSA-140978
(
R-HSA-5357786
)
R-HSA-140978
Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD
See in Reactome
R-HSA-5357776
(
R-HSA-5357956
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357845
(
R-HSA-5357905
)
R-HSA-5357860
(
R-HSA-5357956
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5690827
(
R-HSA-5689896
)
R-HSA-5690827
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1
See in Reactome
R-HSA-5690845
(
R-HSA-5689896
)
R-HSA-5690856
(
R-HSA-5689896
)
R-HSA-5690856
Reaction Name: TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1
See in Reactome
R-HSA-5690870
(
R-HSA-5689896
)
R-HSA-5690870
Reaction Name: OTUD7B,TNFAIP3 deubiquitinate TRAF6
See in Reactome
R-HSA-5693055
(
R-HSA-5357905
)
R-HSA-5693055
Reaction Name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes
See in Reactome
R-HSA-5693108
(
R-HSA-5357905
)
R-HSA-5693108
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains
See in Reactome
R-HSA-688136
(
R-HSA-168638;
R-HSA-5689896
)
R-HSA-688136
Reaction Name: TNFAIP3 (A20) deubiquitinates RIP2
See in Reactome
R-HSA-8869506
(
R-HSA-5689896
)
R-HSA-8869506
Reaction Name: TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6
See in Reactome
R-HSA-937337
(
R-HSA-936440
)
R-HSA-937337
Reaction Name: TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination
See in Reactome
|
MONDO:0015293 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0015884 |
TRAF6 |
Q9Y4K3 |
2.3.2.27
|
R-HSA-937042
R-HSA-937042
Reactome Name: IRAK2 mediated activation of TAK1 complex
See in Reactome
R-HSA-937041
R-HSA-937041
Reactome Name: IKK complex recruitment mediated by RIP1
See in Reactome
R-HSA-937072
R-HSA-937072
Reactome Name: TRAF6-mediated induction of TAK1 complex within TLR4 complex
See in Reactome
R-HSA-168927
R-HSA-168927
Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment
See in Reactome
R-HSA-9020702
R-HSA-1257604
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-975144
R-HSA-975144
Reactome Name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-975163
R-HSA-975163
Reactome Name: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-209543
R-HSA-209543
Reactome Name: p75NTR recruits signalling complexes
See in Reactome
R-HSA-209560
R-HSA-209560
Reactome Name: NF-kB is activated and signals survival
See in Reactome
R-HSA-450321
R-HSA-450321
Reactome Name: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
See in Reactome
R-HSA-933542
R-HSA-933542
Reactome Name: TRAF6 mediated NF-kB activation
See in Reactome
R-HSA-450302
R-HSA-450302
Reactome Name: activated TAK1 mediates p38 MAPK activation
See in Reactome
R-HSA-933541
R-HSA-202424
R-HSA-9645460
R-HSA-9645460
Reactome Name: Alpha-protein kinase 1 signaling pathway
See in Reactome
R-HSA-168638
R-HSA-445989
R-HSA-445989
Reactome Name: TAK1-dependent IKK and NF-kappa-B activation
See in Reactome
R-HSA-205043
R-HSA-205043
Reactome Name: NRIF signals cell death from the nucleus
See in Reactome
R-HSA-937039
R-HSA-193692
R-HSA-193692
Reactome Name: Regulated proteolysis of p75NTR
See in Reactome
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975110
R-HSA-975110
Reactome Name: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-5607764
R-HSA-9014325
R-HSA-9014325
Reactome Name: TICAM1,TRAF6-dependent induction of TAK1 complex
See in Reactome
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-449147
R-HSA-448424
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168898
R-HSA-73887
R-HSA-202403
R-HSA-446652
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-168256
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-392499
R-HSA-193639
R-HSA-166166
R-HSA-450294
R-HSA-5688426
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-204998
R-HSA-204998
Reactome Name: Cell death signalling via NRAGE, NRIF and NADE
See in Reactome
R-HSA-162582
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
|
Immune System
Metabolism of proteins
Signal Transduction
|
R-HSA-166362
(
R-HSA-166058
)
R-HSA-166362
Reaction Name: Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
See in Reactome
R-HSA-166363
(
R-HSA-166058
)
R-HSA-166869
(
R-HSA-166058;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-168184
(
R-HSA-166058;
R-HSA-168638;
R-HSA-445989;
R-HSA-9020702;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-168184
Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex
See in Reactome
R-HSA-168915
(
R-HSA-937041
)
R-HSA-168915
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-177690
(
R-HSA-9014325
)
R-HSA-177690
Reaction Name: Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex
See in Reactome
R-HSA-177692
(
R-HSA-9014325
)
R-HSA-177692
Reaction Name: Activation of recruited TAK1 within the activated TLR3 complex
See in Reactome
R-HSA-177694
(
R-HSA-9014325
)
R-HSA-177694
Reaction Name: Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6
See in Reactome
R-HSA-193641
(
R-HSA-209543
)
R-HSA-193665
(
R-HSA-209543
)
R-HSA-193669
(
R-HSA-205043
)
R-HSA-193684
(
R-HSA-209543
)
R-HSA-193694
(
R-HSA-209543
)
R-HSA-193694
Reaction Name: p62 is recruited and forms a complex with TRAF6
See in Reactome
R-HSA-193695
(
R-HSA-209543
)
R-HSA-193700
(
R-HSA-193692
)
R-HSA-193703
(
R-HSA-209560
)
R-HSA-193705
(
R-HSA-209560
)
R-HSA-193705
Reaction Name: IKKbeta phosphorylates IkB causing NF-kB to dissociate
See in Reactome
R-HSA-202453
(
R-HSA-202424
)
R-HSA-202472
(
R-HSA-202424
)
R-HSA-202472
Reaction Name: Translocation of TRAF6 to CBM complex
See in Reactome
R-HSA-202500
(
R-HSA-202424
)
R-HSA-202510
(
R-HSA-202424
)
R-HSA-202510
Reaction Name: Activation of TAK1-TAB2 complex
See in Reactome
R-HSA-202534
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-202534
Reaction Name: Ubiquitination of NEMO by TRAF6
See in Reactome
R-HSA-204949
(
R-HSA-205043
)
R-HSA-204949
Reaction Name: NRIF and TRAF6 may activate JNK
See in Reactome
R-HSA-205112
(
R-HSA-205043
)
R-HSA-205112
Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6
See in Reactome
R-HSA-205118
(
R-HSA-205043
)
R-HSA-209566
(
R-HSA-209543
)
R-HSA-2262775
(
R-HSA-166058
)
R-HSA-2262775
Reaction Name: Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
See in Reactome
R-HSA-2262777
(
R-HSA-166058
)
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2730861
(
R-HSA-2871837
)
R-HSA-2730861
Reaction Name: Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6
See in Reactome
R-HSA-2730864
(
R-HSA-2871837
)
R-HSA-2730864
Reaction Name: Recruitment of TRAF6 to CBM complex by binding to MALT1
See in Reactome
R-HSA-2730876
(
R-HSA-2871837
)
R-HSA-2730876
Reaction Name: Phosphorylation of IKK-beta by TAK1
See in Reactome
R-HSA-2730900
(
R-HSA-2871837
)
R-HSA-2730900
Reaction Name: Activation of TAK1 complex bound to pUb-TRAF6
See in Reactome
R-HSA-2730903
(
R-HSA-2871837
)
R-HSA-2730904
(
R-HSA-2871837
)
R-HSA-446862
(
R-HSA-9020702
)
R-HSA-446862
Reaction Name: Hyperphosphorylated IRAK1 associates with TRAF6
See in Reactome
R-HSA-446870
(
R-HSA-9020702
)
R-HSA-446870
Reaction Name: Polyubiquitinated TRAF6 binds the TAK1 complex
See in Reactome
R-HSA-446877
(
R-HSA-9020702
)
R-HSA-446877
Reaction Name: TRAF6 is K63 poly-ubiquitinated
See in Reactome
R-HSA-446894
(
R-HSA-9020702
)
R-HSA-446894
Reaction Name: TRAF6 binding leads to IRAK1:TRAF6 release
See in Reactome
R-HSA-450173
(
R-HSA-9020702
)
R-HSA-450173
Reaction Name: IRAK1 induces oligomerisation of TRAF6
See in Reactome
R-HSA-450187
(
R-HSA-9020702
)
R-HSA-450187
Reaction Name: TAK1 is activated within the TAK1 complex
See in Reactome
R-HSA-450259
(
R-HSA-9014325
)
R-HSA-450259
Reaction Name: Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex
See in Reactome
R-HSA-450337
(
R-HSA-166058;
R-HSA-450321;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-450337
Reaction Name: Activated TAK1 phosphorylates MKK4/MKK7
See in Reactome
R-HSA-450346
(
R-HSA-166058;
R-HSA-450302;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-450346
Reaction Name: activated human TAK1 phosphorylates MKK3/MKK6
See in Reactome
R-HSA-450358
(
R-HSA-937072;
R-HSA-975138;
R-HSA-975155;
R-HSA-975163
)
R-HSA-450358
Reaction Name: Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
See in Reactome
R-HSA-507719
(
R-HSA-9020702
)
R-HSA-5607732
(
R-HSA-5607764
)
R-HSA-5607732
Reaction Name: K63polyUb-TAK1 autophosphorylates
See in Reactome
R-HSA-5607742
(
R-HSA-5607764
)
R-HSA-5607742
Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
See in Reactome
R-HSA-5607747
(
R-HSA-5607764
)
R-HSA-5607751
(
R-HSA-5607764
)
R-HSA-5607756
(
R-HSA-5607764
)
R-HSA-5607756
Reaction Name: TRAF6 oligomer autoubiquitinates
See in Reactome
R-HSA-5607757
(
R-HSA-5607764
)
R-HSA-5607757
Reaction Name: K63polyUb-TRAF6 ubiquitinates TAK1
See in Reactome
R-HSA-5607759
(
R-HSA-5607764
)
R-HSA-5607759
Reaction Name: TRIKA2 binds K63polyUb-TRAF6 oligomer
See in Reactome
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-5690870
(
R-HSA-5689896
)
R-HSA-5690870
Reaction Name: OTUD7B,TNFAIP3 deubiquitinate TRAF6
See in Reactome
R-HSA-5696627
(
R-HSA-5689880
)
R-HSA-5696627
Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
See in Reactome
R-HSA-688137
(
R-HSA-168638
)
R-HSA-741386
(
R-HSA-168638
)
R-HSA-741386
Reaction Name: RIP2 induces K63-linked ubiquitination of NEMO
See in Reactome
R-HSA-847070
(
R-HSA-9014325
)
R-HSA-847070
Reaction Name: Phosphorylated TAK1 dissociates from the TLR3 receptor complex
See in Reactome
R-HSA-8869456
(
R-HSA-5689880
)
R-HSA-8869456
Reaction Name: USP4 deubiquitinate TRAF2,TRAF6
See in Reactome
R-HSA-8869506
(
R-HSA-5689896
)
R-HSA-8869506
Reaction Name: TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6
See in Reactome
R-HSA-8948015
(
R-HSA-9020702
)
R-HSA-8948015
Reaction Name: hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb
See in Reactome
R-HSA-8948018
(
R-HSA-9020702
)
R-HSA-8948018
Reaction Name: UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1
See in Reactome
R-HSA-9014342
(
R-HSA-168927
)
R-HSA-9014342
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-918230
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-918230
Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1
See in Reactome
R-HSA-933525
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933525
Reaction Name: Phosphorylation and release of IRF7
See in Reactome
R-HSA-933527
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933527
Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6
See in Reactome
R-HSA-933528
(
R-HSA-168928;
R-HSA-933542
)
R-HSA-933528
Reaction Name: Interaction of MEKK1 with TRAF6
See in Reactome
R-HSA-933530
(
R-HSA-168928;
R-HSA-933542
)
R-HSA-933537
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933538
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-936942
(
R-HSA-166058;
R-HSA-937042;
R-HSA-975871
)
R-HSA-936942
Reaction Name: Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2
See in Reactome
R-HSA-936947
(
R-HSA-937072
)
R-HSA-936947
Reaction Name: Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex
See in Reactome
R-HSA-936951
(
R-HSA-937072
)
R-HSA-936951
Reaction Name: Activation of TAK1 complex bound to activated TLR4 complex
See in Reactome
R-HSA-936952
(
R-HSA-937072
)
R-HSA-936952
Reaction Name: Auto ubiquitination of TRAF6 bound to the activated TLR4 complex
See in Reactome
R-HSA-936960
(
R-HSA-166058;
R-HSA-937042;
R-HSA-975871
)
R-HSA-936960
Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex
See in Reactome
R-HSA-936963
(
R-HSA-166058;
R-HSA-937042;
R-HSA-975871
)
R-HSA-936963
Reaction Name: IRAK2 induces TRAF6 oligomerization
See in Reactome
R-HSA-936985
(
R-HSA-937072
)
R-HSA-936985
Reaction Name: Activated TLR4:TICAM1 recruits TRAF6
See in Reactome
R-HSA-936986
(
R-HSA-166058;
R-HSA-937042;
R-HSA-975871
)
R-HSA-936986
Reaction Name: Activated TRAF6 synthesizes unanchored polyubiquitin chains
See in Reactome
R-HSA-936991
(
R-HSA-166058;
R-HSA-937042;
R-HSA-975871
)
R-HSA-936991
Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3
See in Reactome
R-HSA-937032
(
R-HSA-166058;
R-HSA-937039;
R-HSA-975871
)
R-HSA-937032
Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1
See in Reactome
R-HSA-937034
(
R-HSA-166058;
R-HSA-937039;
R-HSA-975871
)
R-HSA-937044
(
R-HSA-166058;
R-HSA-937039;
R-HSA-975871
)
R-HSA-937050
(
R-HSA-166058;
R-HSA-937039;
R-HSA-975871
)
R-HSA-937075
(
R-HSA-937072
)
R-HSA-937075
Reaction Name: Phosphorylated TAK1 leaves activated TLR receptor complex
See in Reactome
R-HSA-9628444
(
R-HSA-9014325
)
R-HSA-9628444
Reaction Name: Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation
See in Reactome
R-HSA-9645394
(
R-HSA-9645460
)
R-HSA-9645394
Reaction Name: Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation
See in Reactome
R-HSA-9645406
(
R-HSA-9645460
)
R-HSA-9645406
Reaction Name: ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)
See in Reactome
R-HSA-9645414
(
R-HSA-9645460
)
R-HSA-9645414
Reaction Name: Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer
See in Reactome
R-HSA-9645442
(
R-HSA-9645460
)
R-HSA-9645442
Reaction Name: Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex
See in Reactome
R-HSA-9645501
(
R-HSA-9645460
)
R-HSA-9645501
Reaction Name: TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex
See in Reactome
R-HSA-9645520
(
R-HSA-9645460
)
R-HSA-9645520
Reaction Name: ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6
See in Reactome
R-HSA-9705145
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-9705323
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-975097
(
R-HSA-975138;
R-HSA-975155;
R-HSA-975163
)
R-HSA-975097
Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-975100
(
R-HSA-975138;
R-HSA-975155
)
R-HSA-975100
Reaction Name: Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex
See in Reactome
R-HSA-975103
(
R-HSA-975138;
R-HSA-975155;
R-HSA-975163
)
R-HSA-975103
Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975106
(
R-HSA-975110;
R-HSA-975155
)
R-HSA-975106
Reaction Name: Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975111
(
R-HSA-975155
)
R-HSA-975111
Reaction Name: TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9
See in Reactome
R-HSA-975118
(
R-HSA-975110;
R-HSA-975155
)
R-HSA-975118
Reaction Name: TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex
See in Reactome
R-HSA-975119
(
R-HSA-975138;
R-HSA-975144;
R-HSA-975155
)
R-HSA-975119
Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9.
See in Reactome
R-HSA-975122
(
R-HSA-975138;
R-HSA-975144;
R-HSA-975155
)
R-HSA-975122
Reaction Name: Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br>
See in Reactome
R-HSA-975139
(
R-HSA-975138;
R-HSA-975144;
R-HSA-975155
)
R-HSA-975139
Reaction Name: IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975142
(
R-HSA-975138;
R-HSA-975144;
R-HSA-975155
)
R-HSA-975142
Reaction Name: Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975147
(
R-HSA-975138;
R-HSA-975155;
R-HSA-975163
)
R-HSA-975147
Reaction Name: Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane
See in Reactome
R-HSA-975185
(
R-HSA-975138;
R-HSA-975155;
R-HSA-975163
)
R-HSA-975185
Reaction Name: IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments
See in Reactome
R-HSA-975188
(
R-HSA-975110;
R-HSA-975155
)
R-HSA-975188
Reaction Name: TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975857
(
R-HSA-975871
)
R-HSA-975857
Reaction Name: TRAF6 binds to hp- IRAK1 or p-IRAK2
See in Reactome
R-HSA-975879
(
R-HSA-975871
)
R-HSA-975879
Reaction Name: Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex
See in Reactome
|
MONDO:0016995 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0017571 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0018005 |
VCP |
P55072 |
3.6.4.6
|
R-HSA-3371511
R-HSA-9646399
R-HSA-110320
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5358346
R-HSA-9013407
R-HSA-532668
R-HSA-532668
Reactome Name: N-glycan trimming in the ER and Calnexin/Calreticulin cycle
See in Reactome
R-HSA-6798695
R-HSA-8876725
R-HSA-8866654
R-HSA-8866654
Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins
See in Reactome
R-HSA-5689877
|
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-382551
R-HSA-5358351
R-HSA-8953897
R-HSA-2262752
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-9612973
R-HSA-168249
R-HSA-9663891
R-HSA-392499
R-HSA-110313
R-HSA-110313
Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
See in Reactome
R-HSA-8852135
R-HSA-1632852
R-HSA-5688426
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-73894
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-162582
R-HSA-73893
|
Immune System
Transport of small molecules
Cellular responses to stimuli
Autophagy
Metabolism of proteins
DNA Repair
Signal Transduction
|
R-HSA-5324632
(
R-HSA-3371511
)
R-HSA-5324632
Reaction Name: Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates
See in Reactome
R-HSA-5362412
(
R-HSA-5358346
)
R-HSA-5362412
Reaction Name: SYVN1 ubiquitinates Hh C-terminal fragments
See in Reactome
R-HSA-5362441
(
R-HSA-5358346
)
R-HSA-5362441
Reaction Name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane
See in Reactome
R-HSA-5362459
(
R-HSA-5358346
)
R-HSA-5362459
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol
See in Reactome
R-HSA-5654985
(
R-HSA-110320
)
R-HSA-5654985
Reaction Name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH
See in Reactome
R-HSA-5654989
(
R-HSA-110320
)
R-HSA-5654989
Reaction Name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA
See in Reactome
R-HSA-5688834
(
R-HSA-5689877
)
R-HSA-6781953
(
R-HSA-5689896
)
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-8850594
(
R-HSA-532668
)
R-HSA-8850594
Reaction Name: Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins
See in Reactome
R-HSA-8866542
(
R-HSA-382556
)
R-HSA-8866542
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol
See in Reactome
R-HSA-8866546
(
R-HSA-382556
)
R-HSA-8866546
Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR
See in Reactome
R-HSA-8866551
(
R-HSA-382556
)
R-HSA-8866551
Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation
See in Reactome
R-HSA-8932276
(
R-HSA-8876725
)
R-HSA-8932276
Reaction Name: VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP
See in Reactome
R-HSA-8943080
(
R-HSA-8866654
)
R-HSA-8943080
Reaction Name: TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11
See in Reactome
R-HSA-8943083
(
R-HSA-8866654
)
R-HSA-8943083
Reaction Name: US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9646347
(
R-HSA-9646399
)
R-HSA-9646347
Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1
See in Reactome
R-HSA-9646354
(
R-HSA-9646399
)
R-HSA-9646354
Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex
See in Reactome
R-HSA-9755507
()
R-HSA-9755507
Reaction Name: UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex
See in Reactome
R-HSA-9758088
()
R-HSA-9758088
Reaction Name: UBXN7 binds VCP hexamer:UBF1:NPLOC4
See in Reactome
R-HSA-9758090
()
R-HSA-9758090
Reaction Name: Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation
See in Reactome
|
MONDO:0018006 |
VCP |
P55072 |
3.6.4.6
|
R-HSA-3371511
R-HSA-9646399
R-HSA-110320
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5358346
R-HSA-9013407
R-HSA-532668
R-HSA-532668
Reactome Name: N-glycan trimming in the ER and Calnexin/Calreticulin cycle
See in Reactome
R-HSA-6798695
R-HSA-8876725
R-HSA-8866654
R-HSA-8866654
Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins
See in Reactome
R-HSA-5689877
|
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-382551
R-HSA-5358351
R-HSA-8953897
R-HSA-2262752
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-9612973
R-HSA-168249
R-HSA-9663891
R-HSA-392499
R-HSA-110313
R-HSA-110313
Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
See in Reactome
R-HSA-8852135
R-HSA-1632852
R-HSA-5688426
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-73894
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-162582
R-HSA-73893
|
Immune System
Transport of small molecules
Cellular responses to stimuli
Autophagy
Metabolism of proteins
DNA Repair
Signal Transduction
|
R-HSA-5324632
(
R-HSA-3371511
)
R-HSA-5324632
Reaction Name: Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates
See in Reactome
R-HSA-5362412
(
R-HSA-5358346
)
R-HSA-5362412
Reaction Name: SYVN1 ubiquitinates Hh C-terminal fragments
See in Reactome
R-HSA-5362441
(
R-HSA-5358346
)
R-HSA-5362441
Reaction Name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane
See in Reactome
R-HSA-5362459
(
R-HSA-5358346
)
R-HSA-5362459
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol
See in Reactome
R-HSA-5654985
(
R-HSA-110320
)
R-HSA-5654985
Reaction Name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH
See in Reactome
R-HSA-5654989
(
R-HSA-110320
)
R-HSA-5654989
Reaction Name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA
See in Reactome
R-HSA-5688834
(
R-HSA-5689877
)
R-HSA-6781953
(
R-HSA-5689896
)
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-8850594
(
R-HSA-532668
)
R-HSA-8850594
Reaction Name: Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins
See in Reactome
R-HSA-8866542
(
R-HSA-382556
)
R-HSA-8866542
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol
See in Reactome
R-HSA-8866546
(
R-HSA-382556
)
R-HSA-8866546
Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR
See in Reactome
R-HSA-8866551
(
R-HSA-382556
)
R-HSA-8866551
Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation
See in Reactome
R-HSA-8932276
(
R-HSA-8876725
)
R-HSA-8932276
Reaction Name: VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP
See in Reactome
R-HSA-8943080
(
R-HSA-8866654
)
R-HSA-8943080
Reaction Name: TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11
See in Reactome
R-HSA-8943083
(
R-HSA-8866654
)
R-HSA-8943083
Reaction Name: US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9646347
(
R-HSA-9646399
)
R-HSA-9646347
Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1
See in Reactome
R-HSA-9646354
(
R-HSA-9646399
)
R-HSA-9646354
Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex
See in Reactome
R-HSA-9755507
()
R-HSA-9755507
Reaction Name: UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex
See in Reactome
R-HSA-9758088
()
R-HSA-9758088
Reaction Name: UBXN7 binds VCP hexamer:UBF1:NPLOC4
See in Reactome
R-HSA-9758090
()
R-HSA-9758090
Reaction Name: Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation
See in Reactome
|
MONDO:0018338 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0018872 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0018908 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0019002 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0019086 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0020849 |
RIPK1 |
Q13546 |
2.7.11.1
|
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-3295583
R-HSA-168927
R-HSA-168927
Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment
See in Reactome
R-HSA-9686347
R-HSA-9686347
Reactome Name: Microbial modulation of RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-937041
R-HSA-937041
Reactome Name: IKK complex recruitment mediated by RIP1
See in Reactome
R-HSA-5213460
R-HSA-5213460
Reactome Name: RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5357905
R-HSA-5218900
R-HSA-140534
R-HSA-140534
Reactome Name: Caspase activation via Death Receptors in the presence of ligand
See in Reactome
R-HSA-2562578
R-HSA-2562578
Reactome Name: TRIF-mediated programmed cell death
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-1810476
R-HSA-1810476
Reactome Name: RIP-mediated NFkB activation via ZBP1
See in Reactome
R-HSA-69416
R-HSA-5675482
R-HSA-5675482
Reactome Name: Regulation of necroptotic cell death
See in Reactome
R-HSA-75893
R-HSA-3371378
R-HSA-5357786
R-HSA-5357786
Reactome Name: TNFR1-induced proapoptotic signaling
See in Reactome
R-HSA-9013957
R-HSA-9013957
Reactome Name: TLR3-mediated TICAM1-dependent programmed cell death
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-168256
R-HSA-382551
R-HSA-5357801
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168898
R-HSA-166166
R-HSA-1606322
R-HSA-1606322
Reactome Name: ZBP1(DAI) mediated induction of type I IFNs
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-983712
R-HSA-5357769
R-HSA-5357769
Reactome Name: Caspase activation via extrinsic apoptotic signalling pathway
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-5218859
R-HSA-73887
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
R-HSA-5688426
R-HSA-109581
R-HSA-2672351
R-HSA-162582
|
Immune System
Transport of small molecules
Programmed Cell Death
Metabolism of proteins
Signal Transduction
|
R-HSA-139952
(
R-HSA-140534
)
R-HSA-139952
Reaction Name: Caspase-8 processing in the DISC
See in Reactome
R-HSA-140978
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-140978
Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD
See in Reactome
R-HSA-141159
(
R-HSA-140534;
R-HSA-69416
)
R-HSA-141159
Reaction Name: TNF-mediated dimerization of procaspase-8
See in Reactome
R-HSA-168910
(
R-HSA-1810476
)
R-HSA-168910
Reaction Name: RIP1 facilitates IKK complex phosphorylation
See in Reactome
R-HSA-168915
(
R-HSA-937041
)
R-HSA-168915
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-168921
(
R-HSA-937041
)
R-HSA-168921
Reaction Name: TRIF:activated TLR3/TLR4 complex recruits RIP1
See in Reactome
R-HSA-168930
(
R-HSA-168927
)
R-HSA-168930
Reaction Name: Viral dsRNA:TLR3:TRIF complex recruits RIP1
See in Reactome
R-HSA-168934
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-168934
Reaction Name: MAVS interacts with RIPK1 and FADD
See in Reactome
R-HSA-1810457
(
R-HSA-1810476
)
R-HSA-1810457
Reaction Name: ZBP1(DAI) recruits RIP1 and RIP3
See in Reactome
R-HSA-2562541
(
R-HSA-2562578
)
R-HSA-2562541
Reaction Name: TLR4-induced ripoptosome assembly
See in Reactome
R-HSA-2562564
(
R-HSA-140534;
R-HSA-2562578
)
R-HSA-2562564
Reaction Name: Caspase-8 processing within TLR4 complex
See in Reactome
R-HSA-2569057
(
R-HSA-2562578
)
R-HSA-2569057
Reaction Name: RIP3 binds TRIF to mediate necroptosis
See in Reactome
R-HSA-3295579
(
R-HSA-3295583
)
R-HSA-3295579
Reaction Name: TRPs transport extracellular Ca2+ to cytosol
See in Reactome
R-HSA-3371360
(
R-HSA-140534;
R-HSA-3371378;
R-HSA-5357905;
R-HSA-75893
)
R-HSA-3371360
Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling
See in Reactome
R-HSA-3465429
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5675482
)
R-HSA-3465429
Reaction Name: FLIP(S) and procaspase-8 form heterodimer
See in Reactome
R-HSA-3465448
(
R-HSA-140534;
R-HSA-3371378
)
R-HSA-3465448
Reaction Name: Caspase-8 and FLIP(L) processing at DISC
See in Reactome
R-HSA-5213462
(
R-HSA-5213460
)
R-HSA-5213464
(
R-HSA-5213460
)
R-HSA-5213466
(
R-HSA-5213460
)
R-HSA-5218891
(
R-HSA-5213460
)
R-HSA-5218891
Reaction Name: RIPK1:RIPK3 oligomer binds MLKL
See in Reactome
R-HSA-5218905
(
R-HSA-5213460
)
R-HSA-5218905
Reaction Name: RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils
See in Reactome
R-HSA-5218906
(
R-HSA-5213460
)
R-HSA-5357757
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357757
Reaction Name: BIRC(cIAP1/2) ubiquitinates RIPK1
See in Reactome
R-HSA-5357776
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357780
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357780
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2)
See in Reactome
R-HSA-5357828
(
R-HSA-5213460;
R-HSA-5357905;
R-HSA-5675482;
R-HSA-75893
)
R-HSA-5357845
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357860
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5357904
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357904
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
See in Reactome
R-HSA-5357927
(
R-HSA-5213460
)
R-HSA-5357928
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357928
Reaction Name: CLIP3 and CYLD bind TNF signaling complex
See in Reactome
R-HSA-5620975
(
R-HSA-5213460
)
R-HSA-5634221
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5634221
Reaction Name: TRAF1 binds TRAF2 within TNFR1 signaling complex
See in Reactome
R-HSA-5675456
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5675482
)
R-HSA-5675456
Reaction Name: FLIP(L) and procaspase-8 form heterodimer
See in Reactome
R-HSA-5690159
(
R-HSA-5689880
)
R-HSA-5690159
Reaction Name: USP21 deubiquitinates RIPK1,DDX58
See in Reactome
R-HSA-5690827
(
R-HSA-5689896
)
R-HSA-5690827
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1
See in Reactome
R-HSA-5690856
(
R-HSA-5689896
)
R-HSA-5690856
Reaction Name: TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1
See in Reactome
R-HSA-5693055
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5693055
Reaction Name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes
See in Reactome
R-HSA-5693108
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5693108
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains
See in Reactome
R-HSA-5696627
(
R-HSA-5689880
)
R-HSA-5696627
Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
See in Reactome
R-HSA-75240
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-75240
Reaction Name: TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8
See in Reactome
R-HSA-83582
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-83582
Reaction Name: TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex.
See in Reactome
R-HSA-83656
(
R-HSA-75893
)
R-HSA-83656
Reaction Name: TNF:TNFR1 binds TRADD, TRAF2 and RIPK1
See in Reactome
R-HSA-9013889
(
R-HSA-9013957
)
R-HSA-9013889
Reaction Name: TLR3-induced ripoptosome assembly
See in Reactome
R-HSA-9013895
(
R-HSA-9013957
)
R-HSA-9013895
Reaction Name: Caspase-8 processing within TLR3 complex
See in Reactome
R-HSA-9013963
(
R-HSA-9013957
)
R-HSA-9013963
Reaction Name: RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis
See in Reactome
R-HSA-9014342
(
R-HSA-168927
)
R-HSA-9014342
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-9014343
(
R-HSA-168927
)
R-HSA-9014343
Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex
See in Reactome
R-HSA-933523
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933523
Reaction Name: Dimerzation of procaspase-8, procaspase-10
See in Reactome
R-HSA-933526
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933526
Reaction Name: Recruitment of caspase-8 and -10 to FADD complex
See in Reactome
R-HSA-933532
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933539
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-937029
(
R-HSA-937041
)
R-HSA-937029
Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1
See in Reactome
R-HSA-9686336
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686338
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686338
Reaction Name: SARS-CoV-1 3a binds the lysosomal membrane
See in Reactome
R-HSA-9686345
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686345
Reaction Name: SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer
See in Reactome
R-HSA-9686920
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9686920
Reaction Name: PELI1 ubiquitinates RIPK3 at K363
See in Reactome
R-HSA-9686922
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9686922
Reaction Name: PELI1 binds activated RIPK1:RIPK3
See in Reactome
R-HSA-9687465
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9687625
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9687638
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9688456
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9688832
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9693978
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9693978
Reaction Name: Small molecule inhibitor binds RIPK1, RIPK3
See in Reactome
R-HSA-9697747
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-9697747
Reaction Name: Caspase-8 and FLIP(L) processing at TNFR signaling complex
See in Reactome
R-HSA-9697750
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-9697750
Reaction Name: RIPK1 is cleaved by CASP8:FLIP(L)
See in Reactome
R-HSA-9701055
(
R-HSA-3295583
)
R-HSA-9701055
Reaction Name: TRPA1 tetramer transports Ca2+ from extracellular region to cytosol
See in Reactome
R-HSA-9701141
(
R-HSA-3295583
)
R-HSA-9701141
Reaction Name: TRPV1 transports Ca2+ from extracellular region to cytosol
See in Reactome
|
MONDO:0021067 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0021100 |
MONDO:0021100
Disease Name: breast neoplasm
All associated enzymes in DAR:
FGFR2
MTOR
FGFR4
ROCK1
RHOA
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0021427 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0023122 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0024535 |
IFIH1 |
Q9BYX4 |
3.6.4.13
|
R-HSA-933542
R-HSA-933542
Reactome Name: TRAF6 mediated NF-kB activation
See in Reactome
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-933541
R-HSA-918233
R-HSA-918233
Reactome Name: TRAF3-dependent IRF activation pathway
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-936440
R-HSA-936440
Reactome Name: Negative regulators of DDX58/IFIH1 signaling
See in Reactome
|
R-HSA-168256
R-HSA-168249
R-HSA-5688426
R-HSA-392499
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
|
Immune System
Metabolism of proteins
|
R-HSA-168909
(
R-HSA-168928
)
R-HSA-168909
Reaction Name: viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS
See in Reactome
R-HSA-168934
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-168934
Reaction Name: MAVS interacts with RIPK1 and FADD
See in Reactome
R-HSA-5696600
(
R-HSA-5689880
)
R-HSA-5696600
Reaction Name: USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1
See in Reactome
R-HSA-913725
(
R-HSA-168928
)
R-HSA-918225
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918225
Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3
See in Reactome
R-HSA-918227
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918229
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918229
Reaction Name: Phosphorylation and release of IRF3/IRF7
See in Reactome
R-HSA-918230
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-918230
Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1
See in Reactome
R-HSA-918232
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-933523
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933523
Reaction Name: Dimerzation of procaspase-8, procaspase-10
See in Reactome
R-HSA-933525
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933525
Reaction Name: Phosphorylation and release of IRF7
See in Reactome
R-HSA-933526
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933526
Reaction Name: Recruitment of caspase-8 and -10 to FADD complex
See in Reactome
R-HSA-933527
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933527
Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6
See in Reactome
R-HSA-933528
(
R-HSA-168928;
R-HSA-933542
)
R-HSA-933528
Reaction Name: Interaction of MEKK1 with TRAF6
See in Reactome
R-HSA-933530
(
R-HSA-168928;
R-HSA-933542
)
R-HSA-933532
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933537
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933538
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933539
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-936378
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-936378
Reaction Name: Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS
See in Reactome
R-HSA-936381
(
R-HSA-168928;
R-HSA-5689896;
R-HSA-936440
)
R-HSA-936412
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-936412
Reaction Name: RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS
See in Reactome
R-HSA-936475
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-936475
Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216
See in Reactome
R-HSA-937343
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-937343
Reaction Name: NLRC5 interacts with DDX58/IFIH1
See in Reactome
R-HSA-9705137
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-9705137
Reaction Name: TBK1 or IKBKE forms homodimers
See in Reactome
R-HSA-9705145
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-9705320
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-9705320
Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172
See in Reactome
R-HSA-9705323
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-990526
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-990526
Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS
See in Reactome
R-HSA-990528
(
R-HSA-168928;
R-HSA-936440
)
|
MONDO:0025351 |
OTUD5 |
Q96G74 |
3.4.19.12
|
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-936440
R-HSA-936440
Reactome Name: Negative regulators of DDX58/IFIH1 signaling
See in Reactome
|
R-HSA-168249
R-HSA-168256
R-HSA-392499
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-5688426
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
|
Immune System
Metabolism of proteins
|
R-HSA-936381
(
R-HSA-168928;
R-HSA-5689896;
R-HSA-936440
)
|
MONDO:0030018 |
RIPK1 |
Q13546 |
2.7.11.1
|
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-3295583
R-HSA-168927
R-HSA-168927
Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment
See in Reactome
R-HSA-9686347
R-HSA-9686347
Reactome Name: Microbial modulation of RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-937041
R-HSA-937041
Reactome Name: IKK complex recruitment mediated by RIP1
See in Reactome
R-HSA-5213460
R-HSA-5213460
Reactome Name: RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5357905
R-HSA-5218900
R-HSA-140534
R-HSA-140534
Reactome Name: Caspase activation via Death Receptors in the presence of ligand
See in Reactome
R-HSA-2562578
R-HSA-2562578
Reactome Name: TRIF-mediated programmed cell death
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-1810476
R-HSA-1810476
Reactome Name: RIP-mediated NFkB activation via ZBP1
See in Reactome
R-HSA-69416
R-HSA-5675482
R-HSA-5675482
Reactome Name: Regulation of necroptotic cell death
See in Reactome
R-HSA-75893
R-HSA-3371378
R-HSA-5357786
R-HSA-5357786
Reactome Name: TNFR1-induced proapoptotic signaling
See in Reactome
R-HSA-9013957
R-HSA-9013957
Reactome Name: TLR3-mediated TICAM1-dependent programmed cell death
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-168256
R-HSA-382551
R-HSA-5357801
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168898
R-HSA-166166
R-HSA-1606322
R-HSA-1606322
Reactome Name: ZBP1(DAI) mediated induction of type I IFNs
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-983712
R-HSA-5357769
R-HSA-5357769
Reactome Name: Caspase activation via extrinsic apoptotic signalling pathway
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-5218859
R-HSA-73887
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
R-HSA-5688426
R-HSA-109581
R-HSA-2672351
R-HSA-162582
|
Immune System
Transport of small molecules
Programmed Cell Death
Metabolism of proteins
Signal Transduction
|
R-HSA-139952
(
R-HSA-140534
)
R-HSA-139952
Reaction Name: Caspase-8 processing in the DISC
See in Reactome
R-HSA-140978
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-140978
Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD
See in Reactome
R-HSA-141159
(
R-HSA-140534;
R-HSA-69416
)
R-HSA-141159
Reaction Name: TNF-mediated dimerization of procaspase-8
See in Reactome
R-HSA-168910
(
R-HSA-1810476
)
R-HSA-168910
Reaction Name: RIP1 facilitates IKK complex phosphorylation
See in Reactome
R-HSA-168915
(
R-HSA-937041
)
R-HSA-168915
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-168921
(
R-HSA-937041
)
R-HSA-168921
Reaction Name: TRIF:activated TLR3/TLR4 complex recruits RIP1
See in Reactome
R-HSA-168930
(
R-HSA-168927
)
R-HSA-168930
Reaction Name: Viral dsRNA:TLR3:TRIF complex recruits RIP1
See in Reactome
R-HSA-168934
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-168934
Reaction Name: MAVS interacts with RIPK1 and FADD
See in Reactome
R-HSA-1810457
(
R-HSA-1810476
)
R-HSA-1810457
Reaction Name: ZBP1(DAI) recruits RIP1 and RIP3
See in Reactome
R-HSA-2562541
(
R-HSA-2562578
)
R-HSA-2562541
Reaction Name: TLR4-induced ripoptosome assembly
See in Reactome
R-HSA-2562564
(
R-HSA-140534;
R-HSA-2562578
)
R-HSA-2562564
Reaction Name: Caspase-8 processing within TLR4 complex
See in Reactome
R-HSA-2569057
(
R-HSA-2562578
)
R-HSA-2569057
Reaction Name: RIP3 binds TRIF to mediate necroptosis
See in Reactome
R-HSA-3295579
(
R-HSA-3295583
)
R-HSA-3295579
Reaction Name: TRPs transport extracellular Ca2+ to cytosol
See in Reactome
R-HSA-3371360
(
R-HSA-140534;
R-HSA-3371378;
R-HSA-5357905;
R-HSA-75893
)
R-HSA-3371360
Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling
See in Reactome
R-HSA-3465429
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5675482
)
R-HSA-3465429
Reaction Name: FLIP(S) and procaspase-8 form heterodimer
See in Reactome
R-HSA-3465448
(
R-HSA-140534;
R-HSA-3371378
)
R-HSA-3465448
Reaction Name: Caspase-8 and FLIP(L) processing at DISC
See in Reactome
R-HSA-5213462
(
R-HSA-5213460
)
R-HSA-5213464
(
R-HSA-5213460
)
R-HSA-5213466
(
R-HSA-5213460
)
R-HSA-5218891
(
R-HSA-5213460
)
R-HSA-5218891
Reaction Name: RIPK1:RIPK3 oligomer binds MLKL
See in Reactome
R-HSA-5218905
(
R-HSA-5213460
)
R-HSA-5218905
Reaction Name: RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils
See in Reactome
R-HSA-5218906
(
R-HSA-5213460
)
R-HSA-5357757
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357757
Reaction Name: BIRC(cIAP1/2) ubiquitinates RIPK1
See in Reactome
R-HSA-5357776
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357780
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357780
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2)
See in Reactome
R-HSA-5357828
(
R-HSA-5213460;
R-HSA-5357905;
R-HSA-5675482;
R-HSA-75893
)
R-HSA-5357845
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357860
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5357904
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357904
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
See in Reactome
R-HSA-5357927
(
R-HSA-5213460
)
R-HSA-5357928
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357928
Reaction Name: CLIP3 and CYLD bind TNF signaling complex
See in Reactome
R-HSA-5620975
(
R-HSA-5213460
)
R-HSA-5634221
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5634221
Reaction Name: TRAF1 binds TRAF2 within TNFR1 signaling complex
See in Reactome
R-HSA-5675456
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5675482
)
R-HSA-5675456
Reaction Name: FLIP(L) and procaspase-8 form heterodimer
See in Reactome
R-HSA-5690159
(
R-HSA-5689880
)
R-HSA-5690159
Reaction Name: USP21 deubiquitinates RIPK1,DDX58
See in Reactome
R-HSA-5690827
(
R-HSA-5689896
)
R-HSA-5690827
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1
See in Reactome
R-HSA-5690856
(
R-HSA-5689896
)
R-HSA-5690856
Reaction Name: TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1
See in Reactome
R-HSA-5693055
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5693055
Reaction Name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes
See in Reactome
R-HSA-5693108
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5693108
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains
See in Reactome
R-HSA-5696627
(
R-HSA-5689880
)
R-HSA-5696627
Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
See in Reactome
R-HSA-75240
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-75240
Reaction Name: TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8
See in Reactome
R-HSA-83582
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-83582
Reaction Name: TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex.
See in Reactome
R-HSA-83656
(
R-HSA-75893
)
R-HSA-83656
Reaction Name: TNF:TNFR1 binds TRADD, TRAF2 and RIPK1
See in Reactome
R-HSA-9013889
(
R-HSA-9013957
)
R-HSA-9013889
Reaction Name: TLR3-induced ripoptosome assembly
See in Reactome
R-HSA-9013895
(
R-HSA-9013957
)
R-HSA-9013895
Reaction Name: Caspase-8 processing within TLR3 complex
See in Reactome
R-HSA-9013963
(
R-HSA-9013957
)
R-HSA-9013963
Reaction Name: RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis
See in Reactome
R-HSA-9014342
(
R-HSA-168927
)
R-HSA-9014342
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-9014343
(
R-HSA-168927
)
R-HSA-9014343
Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex
See in Reactome
R-HSA-933523
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933523
Reaction Name: Dimerzation of procaspase-8, procaspase-10
See in Reactome
R-HSA-933526
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933526
Reaction Name: Recruitment of caspase-8 and -10 to FADD complex
See in Reactome
R-HSA-933532
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933539
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-937029
(
R-HSA-937041
)
R-HSA-937029
Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1
See in Reactome
R-HSA-9686336
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686338
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686338
Reaction Name: SARS-CoV-1 3a binds the lysosomal membrane
See in Reactome
R-HSA-9686345
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686345
Reaction Name: SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer
See in Reactome
R-HSA-9686920
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9686920
Reaction Name: PELI1 ubiquitinates RIPK3 at K363
See in Reactome
R-HSA-9686922
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9686922
Reaction Name: PELI1 binds activated RIPK1:RIPK3
See in Reactome
R-HSA-9687465
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9687625
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9687638
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9688456
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9688832
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9693978
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9693978
Reaction Name: Small molecule inhibitor binds RIPK1, RIPK3
See in Reactome
R-HSA-9697747
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-9697747
Reaction Name: Caspase-8 and FLIP(L) processing at TNFR signaling complex
See in Reactome
R-HSA-9697750
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-9697750
Reaction Name: RIPK1 is cleaved by CASP8:FLIP(L)
See in Reactome
R-HSA-9701055
(
R-HSA-3295583
)
R-HSA-9701055
Reaction Name: TRPA1 tetramer transports Ca2+ from extracellular region to cytosol
See in Reactome
R-HSA-9701141
(
R-HSA-3295583
)
R-HSA-9701141
Reaction Name: TRPV1 transports Ca2+ from extracellular region to cytosol
See in Reactome
|
MONDO:0032884 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0033968 |
RIPK1 |
Q13546 |
2.7.11.1
|
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-3295583
R-HSA-168927
R-HSA-168927
Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment
See in Reactome
R-HSA-9686347
R-HSA-9686347
Reactome Name: Microbial modulation of RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-937041
R-HSA-937041
Reactome Name: IKK complex recruitment mediated by RIP1
See in Reactome
R-HSA-5213460
R-HSA-5213460
Reactome Name: RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5357905
R-HSA-5218900
R-HSA-140534
R-HSA-140534
Reactome Name: Caspase activation via Death Receptors in the presence of ligand
See in Reactome
R-HSA-2562578
R-HSA-2562578
Reactome Name: TRIF-mediated programmed cell death
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-1810476
R-HSA-1810476
Reactome Name: RIP-mediated NFkB activation via ZBP1
See in Reactome
R-HSA-69416
R-HSA-5675482
R-HSA-5675482
Reactome Name: Regulation of necroptotic cell death
See in Reactome
R-HSA-75893
R-HSA-3371378
R-HSA-5357786
R-HSA-5357786
Reactome Name: TNFR1-induced proapoptotic signaling
See in Reactome
R-HSA-9013957
R-HSA-9013957
Reactome Name: TLR3-mediated TICAM1-dependent programmed cell death
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-168256
R-HSA-382551
R-HSA-5357801
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168898
R-HSA-166166
R-HSA-1606322
R-HSA-1606322
Reactome Name: ZBP1(DAI) mediated induction of type I IFNs
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-983712
R-HSA-5357769
R-HSA-5357769
Reactome Name: Caspase activation via extrinsic apoptotic signalling pathway
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-5218859
R-HSA-73887
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
R-HSA-5688426
R-HSA-109581
R-HSA-2672351
R-HSA-162582
|
Immune System
Transport of small molecules
Programmed Cell Death
Metabolism of proteins
Signal Transduction
|
R-HSA-139952
(
R-HSA-140534
)
R-HSA-139952
Reaction Name: Caspase-8 processing in the DISC
See in Reactome
R-HSA-140978
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-140978
Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD
See in Reactome
R-HSA-141159
(
R-HSA-140534;
R-HSA-69416
)
R-HSA-141159
Reaction Name: TNF-mediated dimerization of procaspase-8
See in Reactome
R-HSA-168910
(
R-HSA-1810476
)
R-HSA-168910
Reaction Name: RIP1 facilitates IKK complex phosphorylation
See in Reactome
R-HSA-168915
(
R-HSA-937041
)
R-HSA-168915
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-168921
(
R-HSA-937041
)
R-HSA-168921
Reaction Name: TRIF:activated TLR3/TLR4 complex recruits RIP1
See in Reactome
R-HSA-168930
(
R-HSA-168927
)
R-HSA-168930
Reaction Name: Viral dsRNA:TLR3:TRIF complex recruits RIP1
See in Reactome
R-HSA-168934
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-168934
Reaction Name: MAVS interacts with RIPK1 and FADD
See in Reactome
R-HSA-1810457
(
R-HSA-1810476
)
R-HSA-1810457
Reaction Name: ZBP1(DAI) recruits RIP1 and RIP3
See in Reactome
R-HSA-2562541
(
R-HSA-2562578
)
R-HSA-2562541
Reaction Name: TLR4-induced ripoptosome assembly
See in Reactome
R-HSA-2562564
(
R-HSA-140534;
R-HSA-2562578
)
R-HSA-2562564
Reaction Name: Caspase-8 processing within TLR4 complex
See in Reactome
R-HSA-2569057
(
R-HSA-2562578
)
R-HSA-2569057
Reaction Name: RIP3 binds TRIF to mediate necroptosis
See in Reactome
R-HSA-3295579
(
R-HSA-3295583
)
R-HSA-3295579
Reaction Name: TRPs transport extracellular Ca2+ to cytosol
See in Reactome
R-HSA-3371360
(
R-HSA-140534;
R-HSA-3371378;
R-HSA-5357905;
R-HSA-75893
)
R-HSA-3371360
Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling
See in Reactome
R-HSA-3465429
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5675482
)
R-HSA-3465429
Reaction Name: FLIP(S) and procaspase-8 form heterodimer
See in Reactome
R-HSA-3465448
(
R-HSA-140534;
R-HSA-3371378
)
R-HSA-3465448
Reaction Name: Caspase-8 and FLIP(L) processing at DISC
See in Reactome
R-HSA-5213462
(
R-HSA-5213460
)
R-HSA-5213464
(
R-HSA-5213460
)
R-HSA-5213466
(
R-HSA-5213460
)
R-HSA-5218891
(
R-HSA-5213460
)
R-HSA-5218891
Reaction Name: RIPK1:RIPK3 oligomer binds MLKL
See in Reactome
R-HSA-5218905
(
R-HSA-5213460
)
R-HSA-5218905
Reaction Name: RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils
See in Reactome
R-HSA-5218906
(
R-HSA-5213460
)
R-HSA-5357757
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357757
Reaction Name: BIRC(cIAP1/2) ubiquitinates RIPK1
See in Reactome
R-HSA-5357776
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357780
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357780
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2)
See in Reactome
R-HSA-5357828
(
R-HSA-5213460;
R-HSA-5357905;
R-HSA-5675482;
R-HSA-75893
)
R-HSA-5357845
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357860
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5357904
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357904
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
See in Reactome
R-HSA-5357927
(
R-HSA-5213460
)
R-HSA-5357928
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357928
Reaction Name: CLIP3 and CYLD bind TNF signaling complex
See in Reactome
R-HSA-5620975
(
R-HSA-5213460
)
R-HSA-5634221
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5634221
Reaction Name: TRAF1 binds TRAF2 within TNFR1 signaling complex
See in Reactome
R-HSA-5675456
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5675482
)
R-HSA-5675456
Reaction Name: FLIP(L) and procaspase-8 form heterodimer
See in Reactome
R-HSA-5690159
(
R-HSA-5689880
)
R-HSA-5690159
Reaction Name: USP21 deubiquitinates RIPK1,DDX58
See in Reactome
R-HSA-5690827
(
R-HSA-5689896
)
R-HSA-5690827
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1
See in Reactome
R-HSA-5690856
(
R-HSA-5689896
)
R-HSA-5690856
Reaction Name: TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1
See in Reactome
R-HSA-5693055
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5693055
Reaction Name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes
See in Reactome
R-HSA-5693108
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5693108
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains
See in Reactome
R-HSA-5696627
(
R-HSA-5689880
)
R-HSA-5696627
Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
See in Reactome
R-HSA-75240
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-75240
Reaction Name: TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8
See in Reactome
R-HSA-83582
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-83582
Reaction Name: TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex.
See in Reactome
R-HSA-83656
(
R-HSA-75893
)
R-HSA-83656
Reaction Name: TNF:TNFR1 binds TRADD, TRAF2 and RIPK1
See in Reactome
R-HSA-9013889
(
R-HSA-9013957
)
R-HSA-9013889
Reaction Name: TLR3-induced ripoptosome assembly
See in Reactome
R-HSA-9013895
(
R-HSA-9013957
)
R-HSA-9013895
Reaction Name: Caspase-8 processing within TLR3 complex
See in Reactome
R-HSA-9013963
(
R-HSA-9013957
)
R-HSA-9013963
Reaction Name: RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis
See in Reactome
R-HSA-9014342
(
R-HSA-168927
)
R-HSA-9014342
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-9014343
(
R-HSA-168927
)
R-HSA-9014343
Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex
See in Reactome
R-HSA-933523
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933523
Reaction Name: Dimerzation of procaspase-8, procaspase-10
See in Reactome
R-HSA-933526
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933526
Reaction Name: Recruitment of caspase-8 and -10 to FADD complex
See in Reactome
R-HSA-933532
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933539
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-937029
(
R-HSA-937041
)
R-HSA-937029
Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1
See in Reactome
R-HSA-9686336
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686338
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686338
Reaction Name: SARS-CoV-1 3a binds the lysosomal membrane
See in Reactome
R-HSA-9686345
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686345
Reaction Name: SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer
See in Reactome
R-HSA-9686920
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9686920
Reaction Name: PELI1 ubiquitinates RIPK3 at K363
See in Reactome
R-HSA-9686922
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9686922
Reaction Name: PELI1 binds activated RIPK1:RIPK3
See in Reactome
R-HSA-9687465
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9687625
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9687638
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9688456
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9688832
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9693978
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9693978
Reaction Name: Small molecule inhibitor binds RIPK1, RIPK3
See in Reactome
R-HSA-9697747
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-9697747
Reaction Name: Caspase-8 and FLIP(L) processing at TNFR signaling complex
See in Reactome
R-HSA-9697750
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-9697750
Reaction Name: RIPK1 is cleaved by CASP8:FLIP(L)
See in Reactome
R-HSA-9701055
(
R-HSA-3295583
)
R-HSA-9701055
Reaction Name: TRPA1 tetramer transports Ca2+ from extracellular region to cytosol
See in Reactome
R-HSA-9701141
(
R-HSA-3295583
)
R-HSA-9701141
Reaction Name: TRPV1 transports Ca2+ from extracellular region to cytosol
See in Reactome
|
MONDO:0035124 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0044638 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0044704 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0044705 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0044740 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|