MONDO:0000437 |
PTRH2 |
Q9Y3E5 |
3.1.1.29
|
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
|
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5688426
R-HSA-392499
|
Metabolism of proteins
|
R-HSA-5696872
(
R-HSA-5689880
)
R-HSA-5696872
Reaction Name: USP30 deubiquitinates Ub-MOM proteins
See in Reactome
|
MONDO:0005595 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0007522 |
TGFBR1 |
P36897 |
2.7.11.30
|
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5689603
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
|
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-5688426
R-HSA-392499
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-170835
(
R-HSA-2173789
)
R-HSA-170835
Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
See in Reactome
R-HSA-170843
(
R-HSA-2173789
)
R-HSA-170846
(
R-HSA-2173789
)
R-HSA-170850
(
R-HSA-2173789
)
R-HSA-170850
Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR
See in Reactome
R-HSA-170868
(
R-HSA-2173789
)
R-HSA-170868
Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly
See in Reactome
R-HSA-173483
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173483
Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor
See in Reactome
R-HSA-173512
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173512
Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
See in Reactome
R-HSA-178178
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-178218
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178218
Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1
See in Reactome
R-HSA-2127562
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2127562
Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex
See in Reactome
R-HSA-2128994
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2128994
Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-2169046
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169046
Reaction Name: Degradation of TGF-beta receptor complex
See in Reactome
R-HSA-2169050
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169050
Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
See in Reactome
R-HSA-2179291
(
R-HSA-2173788;
R-HSA-2173789;
R-HSA-5689603
)
R-HSA-2179291
Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1
See in Reactome
R-HSA-2179293
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2179293
Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1
See in Reactome
R-HSA-6781764
(
R-HSA-5689880
)
R-HSA-6781764
Reaction Name: USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1
See in Reactome
|
MONDO:0007565 |
CYLD |
Q9NQC7 |
3.4.19.12
|
R-HSA-5357786
R-HSA-5357786
Reactome Name: TNFR1-induced proapoptotic signaling
See in Reactome
R-HSA-168638
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-936440
R-HSA-936440
Reactome Name: Negative regulators of DDX58/IFIH1 signaling
See in Reactome
R-HSA-5357905
|
R-HSA-5688426
R-HSA-168256
R-HSA-392499
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-73887
R-HSA-75893
R-HSA-168249
R-HSA-162582
|
Immune System
Metabolism of proteins
Signal Transduction
|
R-HSA-140978
(
R-HSA-5357786
)
R-HSA-140978
Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD
See in Reactome
R-HSA-5357776
(
R-HSA-5357956
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357831
(
R-HSA-5357905
)
R-HSA-5357845
(
R-HSA-5357905
)
R-HSA-5357860
(
R-HSA-5357956
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5357928
(
R-HSA-5357905
)
R-HSA-5357928
Reaction Name: CLIP3 and CYLD bind TNF signaling complex
See in Reactome
R-HSA-5696627
(
R-HSA-5689880
)
R-HSA-5696627
Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
See in Reactome
R-HSA-741411
(
R-HSA-168638
)
R-HSA-936390
(
R-HSA-5689880;
R-HSA-936440
)
R-HSA-936390
Reaction Name: CYLD mediated deubiquitination of DDX58 (RIG-I)
See in Reactome
|
MONDO:0007566 |
TGFBR1 |
P36897 |
2.7.11.30
|
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5689603
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
|
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-5688426
R-HSA-392499
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-170835
(
R-HSA-2173789
)
R-HSA-170835
Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
See in Reactome
R-HSA-170843
(
R-HSA-2173789
)
R-HSA-170846
(
R-HSA-2173789
)
R-HSA-170850
(
R-HSA-2173789
)
R-HSA-170850
Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR
See in Reactome
R-HSA-170868
(
R-HSA-2173789
)
R-HSA-170868
Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly
See in Reactome
R-HSA-173483
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173483
Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor
See in Reactome
R-HSA-173512
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173512
Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
See in Reactome
R-HSA-178178
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-178218
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178218
Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1
See in Reactome
R-HSA-2127562
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2127562
Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex
See in Reactome
R-HSA-2128994
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2128994
Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-2169046
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169046
Reaction Name: Degradation of TGF-beta receptor complex
See in Reactome
R-HSA-2169050
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169050
Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
See in Reactome
R-HSA-2179291
(
R-HSA-2173788;
R-HSA-2173789;
R-HSA-5689603
)
R-HSA-2179291
Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1
See in Reactome
R-HSA-2179293
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2179293
Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1
See in Reactome
R-HSA-6781764
(
R-HSA-5689880
)
R-HSA-6781764
Reaction Name: USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1
See in Reactome
|
MONDO:0007774 |
MONDO:0007774
Disease Name: hyperreflexia
OMIM id: OMIM:145290
All associated enzymes in DAR:
IFIH1
. The disease is also associated to other non-enzyme proteins (not in DAR).
IFIH1 |
Q9BYX4 |
3.6.4.13
|
R-HSA-933542
R-HSA-933542
Reactome Name: TRAF6 mediated NF-kB activation
See in Reactome
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-933541
R-HSA-918233
R-HSA-918233
Reactome Name: TRAF3-dependent IRF activation pathway
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-936440
R-HSA-936440
Reactome Name: Negative regulators of DDX58/IFIH1 signaling
See in Reactome
|
R-HSA-168256
R-HSA-168249
R-HSA-5688426
R-HSA-392499
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
|
Immune System
Metabolism of proteins
|
R-HSA-168909
(
R-HSA-168928
)
R-HSA-168909
Reaction Name: viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS
See in Reactome
R-HSA-168934
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-168934
Reaction Name: MAVS interacts with RIPK1 and FADD
See in Reactome
R-HSA-5696600
(
R-HSA-5689880
)
R-HSA-5696600
Reaction Name: USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1
See in Reactome
R-HSA-913725
(
R-HSA-168928
)
R-HSA-918225
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918225
Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3
See in Reactome
R-HSA-918227
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918229
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-918229
Reaction Name: Phosphorylation and release of IRF3/IRF7
See in Reactome
R-HSA-918230
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-918230
Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1
See in Reactome
R-HSA-918232
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-933523
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933523
Reaction Name: Dimerzation of procaspase-8, procaspase-10
See in Reactome
R-HSA-933525
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933525
Reaction Name: Phosphorylation and release of IRF7
See in Reactome
R-HSA-933526
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933526
Reaction Name: Recruitment of caspase-8 and -10 to FADD complex
See in Reactome
R-HSA-933527
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933527
Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6
See in Reactome
R-HSA-933528
(
R-HSA-168928;
R-HSA-933542
)
R-HSA-933528
Reaction Name: Interaction of MEKK1 with TRAF6
See in Reactome
R-HSA-933530
(
R-HSA-168928;
R-HSA-933542
)
R-HSA-933532
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-933537
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933538
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-933539
(
R-HSA-168928;
R-HSA-933543
)
R-HSA-936378
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-936378
Reaction Name: Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS
See in Reactome
R-HSA-936381
(
R-HSA-168928;
R-HSA-5689896;
R-HSA-936440
)
R-HSA-936412
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-936412
Reaction Name: RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS
See in Reactome
R-HSA-936475
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-936475
Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216
See in Reactome
R-HSA-937343
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-937343
Reaction Name: NLRC5 interacts with DDX58/IFIH1
See in Reactome
R-HSA-9705137
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-9705137
Reaction Name: TBK1 or IKBKE forms homodimers
See in Reactome
R-HSA-9705145
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-9705320
(
R-HSA-168928;
R-HSA-918233
)
R-HSA-9705320
Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172
See in Reactome
R-HSA-9705323
(
R-HSA-168928;
R-HSA-933541
)
R-HSA-990526
(
R-HSA-168928;
R-HSA-936440
)
R-HSA-990526
Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS
See in Reactome
R-HSA-990528
(
R-HSA-168928;
R-HSA-936440
)
|
MONDO:0007924 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0007947 |
TGFBR1 |
P36897 |
2.7.11.30
|
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5689603
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
|
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-5688426
R-HSA-392499
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-170835
(
R-HSA-2173789
)
R-HSA-170835
Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
See in Reactome
R-HSA-170843
(
R-HSA-2173789
)
R-HSA-170846
(
R-HSA-2173789
)
R-HSA-170850
(
R-HSA-2173789
)
R-HSA-170850
Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR
See in Reactome
R-HSA-170868
(
R-HSA-2173789
)
R-HSA-170868
Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly
See in Reactome
R-HSA-173483
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173483
Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor
See in Reactome
R-HSA-173512
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173512
Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
See in Reactome
R-HSA-178178
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-178218
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178218
Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1
See in Reactome
R-HSA-2127562
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2127562
Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex
See in Reactome
R-HSA-2128994
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2128994
Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-2169046
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169046
Reaction Name: Degradation of TGF-beta receptor complex
See in Reactome
R-HSA-2169050
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169050
Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
See in Reactome
R-HSA-2179291
(
R-HSA-2173788;
R-HSA-2173789;
R-HSA-5689603
)
R-HSA-2179291
Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1
See in Reactome
R-HSA-2179293
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2179293
Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1
See in Reactome
R-HSA-6781764
(
R-HSA-5689880
)
R-HSA-6781764
Reaction Name: USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1
See in Reactome
|
MONDO:0008005 |
MAP3K7 |
O43318 |
2.7.11.25
|
R-HSA-9020702
R-HSA-450302
R-HSA-450302
Reactome Name: activated TAK1 mediates p38 MAPK activation
See in Reactome
R-HSA-202424
R-HSA-4086398
R-HSA-937042
R-HSA-937042
Reactome Name: IRAK2 mediated activation of TAK1 complex
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-168638
R-HSA-9645460
R-HSA-9645460
Reactome Name: Alpha-protein kinase 1 signaling pathway
See in Reactome
R-HSA-445989
R-HSA-445989
Reactome Name: TAK1-dependent IKK and NF-kappa-B activation
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-5607764
R-HSA-9014325
R-HSA-9014325
Reactome Name: TICAM1,TRAF6-dependent induction of TAK1 complex
See in Reactome
R-HSA-937072
R-HSA-937072
Reactome Name: TRAF6-mediated induction of TAK1 complex within TLR4 complex
See in Reactome
R-HSA-1169091
R-HSA-1169091
Reactome Name: Activation of NF-kappaB in B cells
See in Reactome
R-HSA-450321
R-HSA-450321
Reactome Name: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
See in Reactome
R-HSA-975163
R-HSA-975163
Reactome Name: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-449147
R-HSA-5688426
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-168898
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-73887
R-HSA-202403
R-HSA-446652
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-392499
R-HSA-166166
R-HSA-75893
R-HSA-450294
R-HSA-195721
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-448424
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-162582
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
|
Immune System
Metabolism of proteins
Signal Transduction
|
R-HSA-1168637
(
R-HSA-1169091
)
R-HSA-1168637
Reaction Name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK
See in Reactome
R-HSA-1168641
(
R-HSA-1169091
)
R-HSA-1168641
Reaction Name: TAK1 associated with the CBM complex phosphorylates IKKbeta
See in Reactome
R-HSA-168184
(
R-HSA-166058;
R-HSA-168638;
R-HSA-445989;
R-HSA-9020702;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-168184
Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex
See in Reactome
R-HSA-177690
(
R-HSA-9014325
)
R-HSA-177690
Reaction Name: Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex
See in Reactome
R-HSA-177692
(
R-HSA-9014325
)
R-HSA-177692
Reaction Name: Activation of recruited TAK1 within the activated TLR3 complex
See in Reactome
R-HSA-202500
(
R-HSA-202424
)
R-HSA-202510
(
R-HSA-202424
)
R-HSA-202510
Reaction Name: Activation of TAK1-TAB2 complex
See in Reactome
R-HSA-2730861
(
R-HSA-2871837
)
R-HSA-2730861
Reaction Name: Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6
See in Reactome
R-HSA-2730876
(
R-HSA-2871837
)
R-HSA-2730876
Reaction Name: Phosphorylation of IKK-beta by TAK1
See in Reactome
R-HSA-2730900
(
R-HSA-2871837
)
R-HSA-2730900
Reaction Name: Activation of TAK1 complex bound to pUb-TRAF6
See in Reactome
R-HSA-4332356
(
R-HSA-4086398
)
R-HSA-4332388
(
R-HSA-4086398
)
R-HSA-4332388
Reaction Name: Activation of MAP3K7 in response to WNT
See in Reactome
R-HSA-4411402
(
R-HSA-4086398
)
R-HSA-446870
(
R-HSA-9020702
)
R-HSA-446870
Reaction Name: Polyubiquitinated TRAF6 binds the TAK1 complex
See in Reactome
R-HSA-450187
(
R-HSA-9020702
)
R-HSA-450187
Reaction Name: TAK1 is activated within the TAK1 complex
See in Reactome
R-HSA-450337
(
R-HSA-166058;
R-HSA-450321;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-450337
Reaction Name: Activated TAK1 phosphorylates MKK4/MKK7
See in Reactome
R-HSA-450346
(
R-HSA-166058;
R-HSA-450302;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-450346
Reaction Name: activated human TAK1 phosphorylates MKK3/MKK6
See in Reactome
R-HSA-5357860
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5607732
(
R-HSA-5607764
)
R-HSA-5607732
Reaction Name: K63polyUb-TAK1 autophosphorylates
See in Reactome
R-HSA-5607742
(
R-HSA-5607764
)
R-HSA-5607742
Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
See in Reactome
R-HSA-5607757
(
R-HSA-5607764
)
R-HSA-5607757
Reaction Name: K63polyUb-TRAF6 ubiquitinates TAK1
See in Reactome
R-HSA-5607759
(
R-HSA-5607764
)
R-HSA-5607759
Reaction Name: TRIKA2 binds K63polyUb-TRAF6 oligomer
See in Reactome
R-HSA-5696534
(
R-HSA-5689880
)
R-HSA-5696534
Reaction Name: USP18 deubiquitinates TAK1:TAB1
See in Reactome
R-HSA-688985
(
R-HSA-168638
)
R-HSA-688985
Reaction Name: K63 polyubiquitinated RIP2 associates with the TAK1 complex
See in Reactome
R-HSA-706479
(
R-HSA-168638
)
R-HSA-727819
(
R-HSA-168638;
R-HSA-9020702
)
R-HSA-847070
(
R-HSA-9014325
)
R-HSA-847070
Reaction Name: Phosphorylated TAK1 dissociates from the TLR3 receptor complex
See in Reactome
R-HSA-936947
(
R-HSA-937072
)
R-HSA-936947
Reaction Name: Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex
See in Reactome
R-HSA-936951
(
R-HSA-937072
)
R-HSA-936951
Reaction Name: Activation of TAK1 complex bound to activated TLR4 complex
See in Reactome
R-HSA-936960
(
R-HSA-166058;
R-HSA-937042;
R-HSA-975871
)
R-HSA-936960
Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex
See in Reactome
R-HSA-936991
(
R-HSA-166058;
R-HSA-937042;
R-HSA-975871
)
R-HSA-936991
Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3
See in Reactome
R-HSA-937075
(
R-HSA-937072
)
R-HSA-937075
Reaction Name: Phosphorylated TAK1 leaves activated TLR receptor complex
See in Reactome
R-HSA-9645406
(
R-HSA-9645460
)
R-HSA-9645406
Reaction Name: ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)
See in Reactome
R-HSA-9645442
(
R-HSA-9645460
)
R-HSA-9645442
Reaction Name: Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex
See in Reactome
R-HSA-975097
(
R-HSA-975138;
R-HSA-975155;
R-HSA-975163
)
R-HSA-975097
Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-975103
(
R-HSA-975138;
R-HSA-975155;
R-HSA-975163
)
R-HSA-975103
Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation
See in Reactome
|
MONDO:0008021 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0008170 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0008185 |
CFTR |
P13569 |
5.6.1.6
|
R-HSA-9613829
R-HSA-8856828
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-8856825
R-HSA-8856825
Reactome Name: Cargo recognition for clathrin-mediated endocytosis
See in Reactome
R-HSA-9615710
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5627083
R-HSA-5627083
Reactome Name: RHO GTPases regulate CFTR trafficking
See in Reactome
R-HSA-9646399
R-HSA-9013406
|
R-HSA-1632852
R-HSA-195258
R-HSA-9612973
R-HSA-9012999
R-HSA-5688426
R-HSA-194315
R-HSA-382551
R-HSA-9663891
R-HSA-199991
R-HSA-392499
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-162582
R-HSA-5653656
|
Autophagy
Transport of small molecules
Metabolism of proteins
Signal Transduction
Vesicle-mediated transport
|
R-HSA-1454916
(
R-HSA-382556
)
R-HSA-1454916
Reaction Name: The ABCC family mediates organic anion transport
See in Reactome
R-HSA-383190
(
R-HSA-382556
)
R-HSA-383190
Reaction Name: HCO3- transport through ion channel
See in Reactome
R-HSA-5627071
(
R-HSA-5627083
)
R-HSA-5627071
Reaction Name: RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane
See in Reactome
R-HSA-5627072
(
R-HSA-5627083;
R-HSA-9013406
)
R-HSA-5627275
(
R-HSA-5627083
)
R-HSA-5627275
Reaction Name: GOPC promotes translocation of CFTR to lysosomes
See in Reactome
R-HSA-5678863
(
R-HSA-382556
)
R-HSA-5678863
Reaction Name: CFTR transports Cl- from cytosol to extracellular region
See in Reactome
R-HSA-6782106
(
R-HSA-5689880
)
R-HSA-6782106
Reaction Name: USP10 deubiquitinates SNX3, CFTR
See in Reactome
R-HSA-8866277
(
R-HSA-8856825;
R-HSA-8856828
)
R-HSA-8866277
Reaction Name: AP-2 directly binds some endocytic cargo
See in Reactome
R-HSA-8866542
(
R-HSA-382556
)
R-HSA-8866542
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol
See in Reactome
R-HSA-8866546
(
R-HSA-382556
)
R-HSA-8866546
Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR
See in Reactome
R-HSA-8866551
(
R-HSA-382556
)
R-HSA-8866551
Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation
See in Reactome
R-HSA-8866553
(
R-HSA-382556
)
R-HSA-8866553
Reaction Name: misfolded CFTR is degraded by the 26S proteasome
See in Reactome
R-HSA-8866851
(
R-HSA-382556
)
R-HSA-8866851
Reaction Name: CFTR transits to the plasma membrane
See in Reactome
R-HSA-8867754
(
R-HSA-8856828
)
R-HSA-8867754
Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit
See in Reactome
R-HSA-8867756
(
R-HSA-8856828
)
R-HSA-8867756
Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
See in Reactome
R-HSA-8868071
(
R-HSA-8856828
)
R-HSA-8868072
(
R-HSA-8856828
)
R-HSA-8868072
Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
See in Reactome
R-HSA-8868230
(
R-HSA-8856828
)
R-HSA-8868230
Reaction Name: SNX9 recruits components of the actin polymerizing machinery
See in Reactome
R-HSA-8868236
(
R-HSA-8856828
)
R-HSA-8868236
Reaction Name: BAR domain proteins recruit dynamin
See in Reactome
R-HSA-8868648
(
R-HSA-8856828
)
R-HSA-8868648
Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P
See in Reactome
R-HSA-8868651
(
R-HSA-8856828
)
R-HSA-8868651
Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit
See in Reactome
R-HSA-8868658
(
R-HSA-8856828
)
R-HSA-8868658
Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
See in Reactome
R-HSA-8868659
(
R-HSA-8856828
)
R-HSA-8868659
Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle
See in Reactome
R-HSA-8868660
(
R-HSA-8856828
)
R-HSA-8868660
Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
See in Reactome
R-HSA-8868661
(
R-HSA-8856828
)
R-HSA-8868661
Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission
See in Reactome
R-HSA-8869438
(
R-HSA-8856828
)
R-HSA-8869438
Reaction Name: Dissociation of clathrin-associated proteins
See in Reactome
R-HSA-8871193
(
R-HSA-8856828
)
R-HSA-8871193
Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2
See in Reactome
R-HSA-8871194
(
R-HSA-8856828
)
R-HSA-9615721
(
R-HSA-9613829;
R-HSA-9615710
)
R-HSA-9620197
(
R-HSA-9613829
)
R-HSA-9622831
(
R-HSA-9613829
)
R-HSA-9622840
(
R-HSA-9613829
)
R-HSA-9622840
Reaction Name: HSPA8 dissociates from LAMP2A-bound substrate
See in Reactome
R-HSA-9624158
(
R-HSA-9613829
)
R-HSA-9624158
Reaction Name: Substrate:LAMP2a:HSP90 polymerizes
See in Reactome
R-HSA-9625188
(
R-HSA-9613829
)
R-HSA-9625188
Reaction Name: HSPA8 transports unfolded substrate to lysosomal lumen for degradation
See in Reactome
R-HSA-9625196
(
R-HSA-9613829
)
R-HSA-9625196
Reaction Name: Unfolded substrate in LAMP2a multimeric complex binds HSPA8
See in Reactome
R-HSA-9625197
(
R-HSA-9613829
)
R-HSA-9626060
(
R-HSA-9613829
)
R-HSA-9626060
Reaction Name: HSPA8:Substrate dissociates from LAMP2a multimer
See in Reactome
R-HSA-9631065
(
R-HSA-9615710
)
R-HSA-9631065
Reaction Name: Substrate translocates into late endosomal lumen
See in Reactome
R-HSA-9631068
(
R-HSA-9615710
)
R-HSA-9631068
Reaction Name: HSPA8:substrate binds late endosomal phospholipids
See in Reactome
R-HSA-9641109
(
R-HSA-9646399
)
R-HSA-9641109
Reaction Name: PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1
See in Reactome
R-HSA-9641111
(
R-HSA-9646399
)
R-HSA-9641111
Reaction Name: Parkin transfers Ub to misfolded proteins
See in Reactome
R-HSA-9641127
(
R-HSA-9646399
)
R-HSA-9641127
Reaction Name: Ub:misfolded proteins polymerize to PolyUb:misfolded proteins
See in Reactome
R-HSA-9646347
(
R-HSA-9646399
)
R-HSA-9646347
Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1
See in Reactome
R-HSA-9646348
(
R-HSA-9646399
)
R-HSA-9646348
Reaction Name: PolyUb-Misfolded Proteins:HDAC6 bind dynein motor
See in Reactome
R-HSA-9646354
(
R-HSA-9646399
)
R-HSA-9646354
Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex
See in Reactome
R-HSA-9646383
(
R-HSA-9646399
)
R-HSA-9646383
Reaction Name: Dynein motors transport misfolded proteins
See in Reactome
R-HSA-9646390
(
R-HSA-9646399
)
R-HSA-9646390
Reaction Name: Misfolded proteins:HDAC6:Dynein motor binds microtubule
See in Reactome
R-HSA-9646679
(
R-HSA-9646399
)
R-HSA-9646679
Reaction Name: PolyUb-Misfolded proteins bind vimentin to form aggresome
See in Reactome
R-HSA-9646685
(
R-HSA-9646399
)
R-HSA-9646685
Reaction Name: Aggresome dissociates from dynein and microtubule
See in Reactome
|
MONDO:0008318 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0008887 |
CFTR |
P13569 |
5.6.1.6
|
R-HSA-9613829
R-HSA-8856828
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-8856825
R-HSA-8856825
Reactome Name: Cargo recognition for clathrin-mediated endocytosis
See in Reactome
R-HSA-9615710
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5627083
R-HSA-5627083
Reactome Name: RHO GTPases regulate CFTR trafficking
See in Reactome
R-HSA-9646399
R-HSA-9013406
|
R-HSA-1632852
R-HSA-195258
R-HSA-9612973
R-HSA-9012999
R-HSA-5688426
R-HSA-194315
R-HSA-382551
R-HSA-9663891
R-HSA-199991
R-HSA-392499
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-162582
R-HSA-5653656
|
Autophagy
Transport of small molecules
Metabolism of proteins
Signal Transduction
Vesicle-mediated transport
|
R-HSA-1454916
(
R-HSA-382556
)
R-HSA-1454916
Reaction Name: The ABCC family mediates organic anion transport
See in Reactome
R-HSA-383190
(
R-HSA-382556
)
R-HSA-383190
Reaction Name: HCO3- transport through ion channel
See in Reactome
R-HSA-5627071
(
R-HSA-5627083
)
R-HSA-5627071
Reaction Name: RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane
See in Reactome
R-HSA-5627072
(
R-HSA-5627083;
R-HSA-9013406
)
R-HSA-5627275
(
R-HSA-5627083
)
R-HSA-5627275
Reaction Name: GOPC promotes translocation of CFTR to lysosomes
See in Reactome
R-HSA-5678863
(
R-HSA-382556
)
R-HSA-5678863
Reaction Name: CFTR transports Cl- from cytosol to extracellular region
See in Reactome
R-HSA-6782106
(
R-HSA-5689880
)
R-HSA-6782106
Reaction Name: USP10 deubiquitinates SNX3, CFTR
See in Reactome
R-HSA-8866277
(
R-HSA-8856825;
R-HSA-8856828
)
R-HSA-8866277
Reaction Name: AP-2 directly binds some endocytic cargo
See in Reactome
R-HSA-8866542
(
R-HSA-382556
)
R-HSA-8866542
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol
See in Reactome
R-HSA-8866546
(
R-HSA-382556
)
R-HSA-8866546
Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR
See in Reactome
R-HSA-8866551
(
R-HSA-382556
)
R-HSA-8866551
Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation
See in Reactome
R-HSA-8866553
(
R-HSA-382556
)
R-HSA-8866553
Reaction Name: misfolded CFTR is degraded by the 26S proteasome
See in Reactome
R-HSA-8866851
(
R-HSA-382556
)
R-HSA-8866851
Reaction Name: CFTR transits to the plasma membrane
See in Reactome
R-HSA-8867754
(
R-HSA-8856828
)
R-HSA-8867754
Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit
See in Reactome
R-HSA-8867756
(
R-HSA-8856828
)
R-HSA-8867756
Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
See in Reactome
R-HSA-8868071
(
R-HSA-8856828
)
R-HSA-8868072
(
R-HSA-8856828
)
R-HSA-8868072
Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
See in Reactome
R-HSA-8868230
(
R-HSA-8856828
)
R-HSA-8868230
Reaction Name: SNX9 recruits components of the actin polymerizing machinery
See in Reactome
R-HSA-8868236
(
R-HSA-8856828
)
R-HSA-8868236
Reaction Name: BAR domain proteins recruit dynamin
See in Reactome
R-HSA-8868648
(
R-HSA-8856828
)
R-HSA-8868648
Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P
See in Reactome
R-HSA-8868651
(
R-HSA-8856828
)
R-HSA-8868651
Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit
See in Reactome
R-HSA-8868658
(
R-HSA-8856828
)
R-HSA-8868658
Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
See in Reactome
R-HSA-8868659
(
R-HSA-8856828
)
R-HSA-8868659
Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle
See in Reactome
R-HSA-8868660
(
R-HSA-8856828
)
R-HSA-8868660
Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
See in Reactome
R-HSA-8868661
(
R-HSA-8856828
)
R-HSA-8868661
Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission
See in Reactome
R-HSA-8869438
(
R-HSA-8856828
)
R-HSA-8869438
Reaction Name: Dissociation of clathrin-associated proteins
See in Reactome
R-HSA-8871193
(
R-HSA-8856828
)
R-HSA-8871193
Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2
See in Reactome
R-HSA-8871194
(
R-HSA-8856828
)
R-HSA-9615721
(
R-HSA-9613829;
R-HSA-9615710
)
R-HSA-9620197
(
R-HSA-9613829
)
R-HSA-9622831
(
R-HSA-9613829
)
R-HSA-9622840
(
R-HSA-9613829
)
R-HSA-9622840
Reaction Name: HSPA8 dissociates from LAMP2A-bound substrate
See in Reactome
R-HSA-9624158
(
R-HSA-9613829
)
R-HSA-9624158
Reaction Name: Substrate:LAMP2a:HSP90 polymerizes
See in Reactome
R-HSA-9625188
(
R-HSA-9613829
)
R-HSA-9625188
Reaction Name: HSPA8 transports unfolded substrate to lysosomal lumen for degradation
See in Reactome
R-HSA-9625196
(
R-HSA-9613829
)
R-HSA-9625196
Reaction Name: Unfolded substrate in LAMP2a multimeric complex binds HSPA8
See in Reactome
R-HSA-9625197
(
R-HSA-9613829
)
R-HSA-9626060
(
R-HSA-9613829
)
R-HSA-9626060
Reaction Name: HSPA8:Substrate dissociates from LAMP2a multimer
See in Reactome
R-HSA-9631065
(
R-HSA-9615710
)
R-HSA-9631065
Reaction Name: Substrate translocates into late endosomal lumen
See in Reactome
R-HSA-9631068
(
R-HSA-9615710
)
R-HSA-9631068
Reaction Name: HSPA8:substrate binds late endosomal phospholipids
See in Reactome
R-HSA-9641109
(
R-HSA-9646399
)
R-HSA-9641109
Reaction Name: PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1
See in Reactome
R-HSA-9641111
(
R-HSA-9646399
)
R-HSA-9641111
Reaction Name: Parkin transfers Ub to misfolded proteins
See in Reactome
R-HSA-9641127
(
R-HSA-9646399
)
R-HSA-9641127
Reaction Name: Ub:misfolded proteins polymerize to PolyUb:misfolded proteins
See in Reactome
R-HSA-9646347
(
R-HSA-9646399
)
R-HSA-9646347
Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1
See in Reactome
R-HSA-9646348
(
R-HSA-9646399
)
R-HSA-9646348
Reaction Name: PolyUb-Misfolded Proteins:HDAC6 bind dynein motor
See in Reactome
R-HSA-9646354
(
R-HSA-9646399
)
R-HSA-9646354
Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex
See in Reactome
R-HSA-9646383
(
R-HSA-9646399
)
R-HSA-9646383
Reaction Name: Dynein motors transport misfolded proteins
See in Reactome
R-HSA-9646390
(
R-HSA-9646399
)
R-HSA-9646390
Reaction Name: Misfolded proteins:HDAC6:Dynein motor binds microtubule
See in Reactome
R-HSA-9646679
(
R-HSA-9646399
)
R-HSA-9646679
Reaction Name: PolyUb-Misfolded proteins bind vimentin to form aggresome
See in Reactome
R-HSA-9646685
(
R-HSA-9646399
)
R-HSA-9646685
Reaction Name: Aggresome dissociates from dynein and microtubule
See in Reactome
|
MONDO:0009050 |
USP8 |
P40818 |
3.4.19.12
|
R-HSA-6807004
R-HSA-6807004
Reactome Name: Negative regulation of MET activity
See in Reactome
R-HSA-4641263
R-HSA-4641263
Reactome Name: Regulation of FZD by ubiquitination
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
|
R-HSA-6806834
R-HSA-195721
R-HSA-5688426
R-HSA-392499
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1358795
(
R-HSA-1358803
)
R-HSA-1358795
Reaction Name: Deubiquitination of RNF41 by P-USP8
See in Reactome
R-HSA-1358797
(
R-HSA-1358803
)
R-HSA-1358797
Reaction Name: Ubiquitinated RNF41 binds P-USP8
See in Reactome
R-HSA-4641236
(
R-HSA-4641263
)
R-HSA-4641236
Reaction Name: USP8 deubiquitinates FZD to potentiate WNT signaling
See in Reactome
R-HSA-5690196
(
R-HSA-5689880
)
R-HSA-6782628
(
R-HSA-5689880
)
R-HSA-6782628
Reaction Name: USP8 deubiquitinates STAM2:HGS
See in Reactome
R-HSA-8875443
(
R-HSA-6807004
)
|
MONDO:0009061 |
CFTR |
P13569 |
5.6.1.6
|
R-HSA-9613829
R-HSA-8856828
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-8856825
R-HSA-8856825
Reactome Name: Cargo recognition for clathrin-mediated endocytosis
See in Reactome
R-HSA-9615710
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5627083
R-HSA-5627083
Reactome Name: RHO GTPases regulate CFTR trafficking
See in Reactome
R-HSA-9646399
R-HSA-9013406
|
R-HSA-1632852
R-HSA-195258
R-HSA-9612973
R-HSA-9012999
R-HSA-5688426
R-HSA-194315
R-HSA-382551
R-HSA-9663891
R-HSA-199991
R-HSA-392499
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-162582
R-HSA-5653656
|
Autophagy
Transport of small molecules
Metabolism of proteins
Signal Transduction
Vesicle-mediated transport
|
R-HSA-1454916
(
R-HSA-382556
)
R-HSA-1454916
Reaction Name: The ABCC family mediates organic anion transport
See in Reactome
R-HSA-383190
(
R-HSA-382556
)
R-HSA-383190
Reaction Name: HCO3- transport through ion channel
See in Reactome
R-HSA-5627071
(
R-HSA-5627083
)
R-HSA-5627071
Reaction Name: RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane
See in Reactome
R-HSA-5627072
(
R-HSA-5627083;
R-HSA-9013406
)
R-HSA-5627275
(
R-HSA-5627083
)
R-HSA-5627275
Reaction Name: GOPC promotes translocation of CFTR to lysosomes
See in Reactome
R-HSA-5678863
(
R-HSA-382556
)
R-HSA-5678863
Reaction Name: CFTR transports Cl- from cytosol to extracellular region
See in Reactome
R-HSA-6782106
(
R-HSA-5689880
)
R-HSA-6782106
Reaction Name: USP10 deubiquitinates SNX3, CFTR
See in Reactome
R-HSA-8866277
(
R-HSA-8856825;
R-HSA-8856828
)
R-HSA-8866277
Reaction Name: AP-2 directly binds some endocytic cargo
See in Reactome
R-HSA-8866542
(
R-HSA-382556
)
R-HSA-8866542
Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol
See in Reactome
R-HSA-8866546
(
R-HSA-382556
)
R-HSA-8866546
Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR
See in Reactome
R-HSA-8866551
(
R-HSA-382556
)
R-HSA-8866551
Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation
See in Reactome
R-HSA-8866553
(
R-HSA-382556
)
R-HSA-8866553
Reaction Name: misfolded CFTR is degraded by the 26S proteasome
See in Reactome
R-HSA-8866851
(
R-HSA-382556
)
R-HSA-8866851
Reaction Name: CFTR transits to the plasma membrane
See in Reactome
R-HSA-8867754
(
R-HSA-8856828
)
R-HSA-8867754
Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit
See in Reactome
R-HSA-8867756
(
R-HSA-8856828
)
R-HSA-8867756
Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
See in Reactome
R-HSA-8868071
(
R-HSA-8856828
)
R-HSA-8868072
(
R-HSA-8856828
)
R-HSA-8868072
Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
See in Reactome
R-HSA-8868230
(
R-HSA-8856828
)
R-HSA-8868230
Reaction Name: SNX9 recruits components of the actin polymerizing machinery
See in Reactome
R-HSA-8868236
(
R-HSA-8856828
)
R-HSA-8868236
Reaction Name: BAR domain proteins recruit dynamin
See in Reactome
R-HSA-8868648
(
R-HSA-8856828
)
R-HSA-8868648
Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P
See in Reactome
R-HSA-8868651
(
R-HSA-8856828
)
R-HSA-8868651
Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit
See in Reactome
R-HSA-8868658
(
R-HSA-8856828
)
R-HSA-8868658
Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
See in Reactome
R-HSA-8868659
(
R-HSA-8856828
)
R-HSA-8868659
Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle
See in Reactome
R-HSA-8868660
(
R-HSA-8856828
)
R-HSA-8868660
Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
See in Reactome
R-HSA-8868661
(
R-HSA-8856828
)
R-HSA-8868661
Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission
See in Reactome
R-HSA-8869438
(
R-HSA-8856828
)
R-HSA-8869438
Reaction Name: Dissociation of clathrin-associated proteins
See in Reactome
R-HSA-8871193
(
R-HSA-8856828
)
R-HSA-8871193
Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2
See in Reactome
R-HSA-8871194
(
R-HSA-8856828
)
R-HSA-9615721
(
R-HSA-9613829;
R-HSA-9615710
)
R-HSA-9620197
(
R-HSA-9613829
)
R-HSA-9622831
(
R-HSA-9613829
)
R-HSA-9622840
(
R-HSA-9613829
)
R-HSA-9622840
Reaction Name: HSPA8 dissociates from LAMP2A-bound substrate
See in Reactome
R-HSA-9624158
(
R-HSA-9613829
)
R-HSA-9624158
Reaction Name: Substrate:LAMP2a:HSP90 polymerizes
See in Reactome
R-HSA-9625188
(
R-HSA-9613829
)
R-HSA-9625188
Reaction Name: HSPA8 transports unfolded substrate to lysosomal lumen for degradation
See in Reactome
R-HSA-9625196
(
R-HSA-9613829
)
R-HSA-9625196
Reaction Name: Unfolded substrate in LAMP2a multimeric complex binds HSPA8
See in Reactome
R-HSA-9625197
(
R-HSA-9613829
)
R-HSA-9626060
(
R-HSA-9613829
)
R-HSA-9626060
Reaction Name: HSPA8:Substrate dissociates from LAMP2a multimer
See in Reactome
R-HSA-9631065
(
R-HSA-9615710
)
R-HSA-9631065
Reaction Name: Substrate translocates into late endosomal lumen
See in Reactome
R-HSA-9631068
(
R-HSA-9615710
)
R-HSA-9631068
Reaction Name: HSPA8:substrate binds late endosomal phospholipids
See in Reactome
R-HSA-9641109
(
R-HSA-9646399
)
R-HSA-9641109
Reaction Name: PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1
See in Reactome
R-HSA-9641111
(
R-HSA-9646399
)
R-HSA-9641111
Reaction Name: Parkin transfers Ub to misfolded proteins
See in Reactome
R-HSA-9641127
(
R-HSA-9646399
)
R-HSA-9641127
Reaction Name: Ub:misfolded proteins polymerize to PolyUb:misfolded proteins
See in Reactome
R-HSA-9646347
(
R-HSA-9646399
)
R-HSA-9646347
Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1
See in Reactome
R-HSA-9646348
(
R-HSA-9646399
)
R-HSA-9646348
Reaction Name: PolyUb-Misfolded Proteins:HDAC6 bind dynein motor
See in Reactome
R-HSA-9646354
(
R-HSA-9646399
)
R-HSA-9646354
Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex
See in Reactome
R-HSA-9646383
(
R-HSA-9646399
)
R-HSA-9646383
Reaction Name: Dynein motors transport misfolded proteins
See in Reactome
R-HSA-9646390
(
R-HSA-9646399
)
R-HSA-9646390
Reaction Name: Misfolded proteins:HDAC6:Dynein motor binds microtubule
See in Reactome
R-HSA-9646679
(
R-HSA-9646399
)
R-HSA-9646679
Reaction Name: PolyUb-Misfolded proteins bind vimentin to form aggresome
See in Reactome
R-HSA-9646685
(
R-HSA-9646399
)
R-HSA-9646685
Reaction Name: Aggresome dissociates from dynein and microtubule
See in Reactome
|
MONDO:0010172 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
|