DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-5689877)

Number of enzymes:	3
Number of disease:	15
Number of reactomes:	16
Number of reactions:	45

Search results (Reactome ID: R-HSA-5689877)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005138	PRKN	O60260	2.3.2.31	R-HSA-5205685 R-HSA-5205685 Reactome Name: PINK1-PRKN Mediated Mitophagy See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-9646399 R-HSA-9646399 Reactome Name: Aggrephagy See in Reactome R-HSA-5689877 R-HSA-5689877 Reactome Name: Josephin domain DUBs See in Reactome R-HSA-977225 R-HSA-977225 Reactome Name: Amyloid fiber formation See in Reactome	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome	Autophagy Immune System Metabolism of proteins	R-HSA-5205652 ( R-HSA-5205685 ) R-HSA-5205652 Reaction Name: Pink1 recruits Parkin to the outer mitochondrial membrane. See in Reactome R-HSA-5205682 ( R-HSA-5205685 ) R-HSA-5205682 Reaction Name: Parkin promotes the ubiquitination of mitochondrial substrates See in Reactome R-HSA-5658574 ( R-HSA-977225 ) R-HSA-5658574 Reaction Name: PARK2 binds SNCAIP See in Reactome R-HSA-5667111 ( R-HSA-977225 ) R-HSA-5667111 Reaction Name: PARK2 K63-Ubiquitinates SNCAIP See in Reactome R-HSA-5688837 ( R-HSA-5689877 ) R-HSA-5688837 Reaction Name: ATXN3 deubiquitinates polyUb-PARK2 See in Reactome R-HSA-5689085 ( R-HSA-5689877 ) R-HSA-5689085 Reaction Name: ATXN3 binds polyUb-PARK2 See in Reactome R-HSA-5689111 ( R-HSA-5689877 ) R-HSA-5689111 Reaction Name: PARK2 autoubiquitinates See in Reactome R-HSA-9641089 ( R-HSA-9646399 ) R-HSA-9641089 Reaction Name: Parkin binds Ub:UBE2N:UBE2V1 See in Reactome R-HSA-9641096 ( R-HSA-9646399 ) R-HSA-9641096 Reaction Name: Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub See in Reactome R-HSA-9641109 ( R-HSA-9646399 ) R-HSA-9641109 Reaction Name: PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 See in Reactome R-HSA-9641111 ( R-HSA-9646399 ) R-HSA-9641111 Reaction Name: Parkin transfers Ub to misfolded proteins See in Reactome R-HSA-9641127 ( R-HSA-9646399 ) R-HSA-9641127 Reaction Name: Ub:misfolded proteins polymerize to PolyUb:misfolded proteins See in Reactome R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome
MONDO:0007088	VCP	P55072	3.6.4.6	R-HSA-3371511 R-HSA-3371511 Reactome Name: HSF1 activation See in Reactome R-HSA-9646399 R-HSA-9646399 Reactome Name: Aggrephagy See in Reactome R-HSA-110320 R-HSA-110320 Reactome Name: Translesion Synthesis by POLH See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-532668 R-HSA-532668 Reactome Name: N-glycan trimming in the ER and Calnexin/Calreticulin cycle See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8876725 R-HSA-8876725 Reactome Name: Protein methylation See in Reactome R-HSA-8866654 R-HSA-8866654 Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins See in Reactome R-HSA-5689877 R-HSA-5689877 Reactome Name: Josephin domain DUBs See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	Immune System Transport of small molecules Cellular responses to stimuli Autophagy Metabolism of proteins DNA Repair Signal Transduction	R-HSA-5324632 ( R-HSA-3371511 ) R-HSA-5324632 Reaction Name: Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates See in Reactome R-HSA-5362412 ( R-HSA-5358346 ) R-HSA-5362412 Reaction Name: SYVN1 ubiquitinates Hh C-terminal fragments See in Reactome R-HSA-5362441 ( R-HSA-5358346 ) R-HSA-5362441 Reaction Name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane See in Reactome R-HSA-5362459 ( R-HSA-5358346 ) R-HSA-5362459 Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol See in Reactome R-HSA-5654985 ( R-HSA-110320 ) R-HSA-5654985 Reaction Name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH See in Reactome R-HSA-5654989 ( R-HSA-110320 ) R-HSA-5654989 Reaction Name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA See in Reactome R-HSA-5688834 ( R-HSA-5689877 ) R-HSA-5688834 Reaction Name: ATXN3 binds VCP See in Reactome R-HSA-6781953 ( R-HSA-5689896 ) R-HSA-6781953 Reaction Name: YOD1 binds VCP See in Reactome R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-8850594 ( R-HSA-532668 ) R-HSA-8850594 Reaction Name: Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins See in Reactome R-HSA-8866542 ( R-HSA-382556 ) R-HSA-8866542 Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol See in Reactome R-HSA-8866546 ( R-HSA-382556 ) R-HSA-8866546 Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR See in Reactome R-HSA-8866551 ( R-HSA-382556 ) R-HSA-8866551 Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation See in Reactome R-HSA-8932276 ( R-HSA-8876725 ) R-HSA-8932276 Reaction Name: VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP See in Reactome R-HSA-8943080 ( R-HSA-8866654 ) R-HSA-8943080 Reaction Name: TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11 See in Reactome R-HSA-8943083 ( R-HSA-8866654 ) R-HSA-8943083 Reaction Name: US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome R-HSA-9646347 ( R-HSA-9646399 ) R-HSA-9646347 Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1 See in Reactome R-HSA-9646354 ( R-HSA-9646399 ) R-HSA-9646354 Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex See in Reactome R-HSA-9755507 () R-HSA-9755507 Reaction Name: UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex See in Reactome R-HSA-9758088 () R-HSA-9758088 Reaction Name: UBXN7 binds VCP hexamer:UBF1:NPLOC4 See in Reactome R-HSA-9758090 () R-HSA-9758090 Reaction Name: Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation See in Reactome
MONDO:0008170	PRKN	O60260	2.3.2.31	R-HSA-5205685 R-HSA-5205685 Reactome Name: PINK1-PRKN Mediated Mitophagy See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-9646399 R-HSA-9646399 Reactome Name: Aggrephagy See in Reactome R-HSA-5689877 R-HSA-5689877 Reactome Name: Josephin domain DUBs See in Reactome R-HSA-977225 R-HSA-977225 Reactome Name: Amyloid fiber formation See in Reactome	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome	Autophagy Immune System Metabolism of proteins	R-HSA-5205652 ( R-HSA-5205685 ) R-HSA-5205652 Reaction Name: Pink1 recruits Parkin to the outer mitochondrial membrane. See in Reactome R-HSA-5205682 ( R-HSA-5205685 ) R-HSA-5205682 Reaction Name: Parkin promotes the ubiquitination of mitochondrial substrates See in Reactome R-HSA-5658574 ( R-HSA-977225 ) R-HSA-5658574 Reaction Name: PARK2 binds SNCAIP See in Reactome R-HSA-5667111 ( R-HSA-977225 ) R-HSA-5667111 Reaction Name: PARK2 K63-Ubiquitinates SNCAIP See in Reactome R-HSA-5688837 ( R-HSA-5689877 ) R-HSA-5688837 Reaction Name: ATXN3 deubiquitinates polyUb-PARK2 See in Reactome R-HSA-5689085 ( R-HSA-5689877 ) R-HSA-5689085 Reaction Name: ATXN3 binds polyUb-PARK2 See in Reactome R-HSA-5689111 ( R-HSA-5689877 ) R-HSA-5689111 Reaction Name: PARK2 autoubiquitinates See in Reactome R-HSA-9641089 ( R-HSA-9646399 ) R-HSA-9641089 Reaction Name: Parkin binds Ub:UBE2N:UBE2V1 See in Reactome R-HSA-9641096 ( R-HSA-9646399 ) R-HSA-9641096 Reaction Name: Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub See in Reactome R-HSA-9641109 ( R-HSA-9646399 ) R-HSA-9641109 Reaction Name: PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 See in Reactome R-HSA-9641111 ( R-HSA-9646399 ) R-HSA-9641111 Reaction Name: Parkin transfers Ub to misfolded proteins See in Reactome R-HSA-9641127 ( R-HSA-9646399 ) R-HSA-9641127 Reaction Name: Ub:misfolded proteins polymerize to PolyUb:misfolded proteins See in Reactome R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome
MONDO:0008178	VCP	P55072	3.6.4.6	R-HSA-3371511 R-HSA-3371511 Reactome Name: HSF1 activation See in Reactome R-HSA-9646399 R-HSA-9646399 Reactome Name: Aggrephagy See in Reactome R-HSA-110320 R-HSA-110320 Reactome Name: Translesion Synthesis by POLH See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-532668 R-HSA-532668 Reactome Name: N-glycan trimming in the ER and Calnexin/Calreticulin cycle See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8876725 R-HSA-8876725 Reactome Name: Protein methylation See in Reactome R-HSA-8866654 R-HSA-8866654 Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins See in Reactome R-HSA-5689877 R-HSA-5689877 Reactome Name: Josephin domain DUBs See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	Immune System Transport of small molecules Cellular responses to stimuli Autophagy Metabolism of proteins DNA Repair Signal Transduction	R-HSA-5324632 ( R-HSA-3371511 ) R-HSA-5324632 Reaction Name: Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates See in Reactome R-HSA-5362412 ( R-HSA-5358346 ) R-HSA-5362412 Reaction Name: SYVN1 ubiquitinates Hh C-terminal fragments See in Reactome R-HSA-5362441 ( R-HSA-5358346 ) R-HSA-5362441 Reaction Name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane See in Reactome R-HSA-5362459 ( R-HSA-5358346 ) R-HSA-5362459 Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol See in Reactome R-HSA-5654985 ( R-HSA-110320 ) R-HSA-5654985 Reaction Name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH See in Reactome R-HSA-5654989 ( R-HSA-110320 ) R-HSA-5654989 Reaction Name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA See in Reactome R-HSA-5688834 ( R-HSA-5689877 ) R-HSA-5688834 Reaction Name: ATXN3 binds VCP See in Reactome R-HSA-6781953 ( R-HSA-5689896 ) R-HSA-6781953 Reaction Name: YOD1 binds VCP See in Reactome R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-8850594 ( R-HSA-532668 ) R-HSA-8850594 Reaction Name: Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins See in Reactome R-HSA-8866542 ( R-HSA-382556 ) R-HSA-8866542 Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol See in Reactome R-HSA-8866546 ( R-HSA-382556 ) R-HSA-8866546 Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR See in Reactome R-HSA-8866551 ( R-HSA-382556 ) R-HSA-8866551 Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation See in Reactome R-HSA-8932276 ( R-HSA-8876725 ) R-HSA-8932276 Reaction Name: VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP See in Reactome R-HSA-8943080 ( R-HSA-8866654 ) R-HSA-8943080 Reaction Name: TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11 See in Reactome R-HSA-8943083 ( R-HSA-8866654 ) R-HSA-8943083 Reaction Name: US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome R-HSA-9646347 ( R-HSA-9646399 ) R-HSA-9646347 Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1 See in Reactome R-HSA-9646354 ( R-HSA-9646399 ) R-HSA-9646354 Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex See in Reactome R-HSA-9755507 () R-HSA-9755507 Reaction Name: UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex See in Reactome R-HSA-9758088 () R-HSA-9758088 Reaction Name: UBXN7 binds VCP hexamer:UBF1:NPLOC4 See in Reactome R-HSA-9758090 () R-HSA-9758090 Reaction Name: Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation See in Reactome
MONDO:0008199	PRKN	O60260	2.3.2.31	R-HSA-5205685 R-HSA-5205685 Reactome Name: PINK1-PRKN Mediated Mitophagy See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-9646399 R-HSA-9646399 Reactome Name: Aggrephagy See in Reactome R-HSA-5689877 R-HSA-5689877 Reactome Name: Josephin domain DUBs See in Reactome R-HSA-977225 R-HSA-977225 Reactome Name: Amyloid fiber formation See in Reactome	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome	Autophagy Immune System Metabolism of proteins	R-HSA-5205652 ( R-HSA-5205685 ) R-HSA-5205652 Reaction Name: Pink1 recruits Parkin to the outer mitochondrial membrane. See in Reactome R-HSA-5205682 ( R-HSA-5205685 ) R-HSA-5205682 Reaction Name: Parkin promotes the ubiquitination of mitochondrial substrates See in Reactome R-HSA-5658574 ( R-HSA-977225 ) R-HSA-5658574 Reaction Name: PARK2 binds SNCAIP See in Reactome R-HSA-5667111 ( R-HSA-977225 ) R-HSA-5667111 Reaction Name: PARK2 K63-Ubiquitinates SNCAIP See in Reactome R-HSA-5688837 ( R-HSA-5689877 ) R-HSA-5688837 Reaction Name: ATXN3 deubiquitinates polyUb-PARK2 See in Reactome R-HSA-5689085 ( R-HSA-5689877 ) R-HSA-5689085 Reaction Name: ATXN3 binds polyUb-PARK2 See in Reactome R-HSA-5689111 ( R-HSA-5689877 ) R-HSA-5689111 Reaction Name: PARK2 autoubiquitinates See in Reactome R-HSA-9641089 ( R-HSA-9646399 ) R-HSA-9641089 Reaction Name: Parkin binds Ub:UBE2N:UBE2V1 See in Reactome R-HSA-9641096 ( R-HSA-9646399 ) R-HSA-9641096 Reaction Name: Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub See in Reactome R-HSA-9641109 ( R-HSA-9646399 ) R-HSA-9641109 Reaction Name: PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 See in Reactome R-HSA-9641111 ( R-HSA-9646399 ) R-HSA-9641111 Reaction Name: Parkin transfers Ub to misfolded proteins See in Reactome R-HSA-9641127 ( R-HSA-9646399 ) R-HSA-9641127 Reaction Name: Ub:misfolded proteins polymerize to PolyUb:misfolded proteins See in Reactome R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome
MONDO:0010820	PRKN	O60260	2.3.2.31	R-HSA-5205685 R-HSA-5205685 Reactome Name: PINK1-PRKN Mediated Mitophagy See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-9646399 R-HSA-9646399 Reactome Name: Aggrephagy See in Reactome R-HSA-5689877 R-HSA-5689877 Reactome Name: Josephin domain DUBs See in Reactome R-HSA-977225 R-HSA-977225 Reactome Name: Amyloid fiber formation See in Reactome	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome	Autophagy Immune System Metabolism of proteins	R-HSA-5205652 ( R-HSA-5205685 ) R-HSA-5205652 Reaction Name: Pink1 recruits Parkin to the outer mitochondrial membrane. See in Reactome R-HSA-5205682 ( R-HSA-5205685 ) R-HSA-5205682 Reaction Name: Parkin promotes the ubiquitination of mitochondrial substrates See in Reactome R-HSA-5658574 ( R-HSA-977225 ) R-HSA-5658574 Reaction Name: PARK2 binds SNCAIP See in Reactome R-HSA-5667111 ( R-HSA-977225 ) R-HSA-5667111 Reaction Name: PARK2 K63-Ubiquitinates SNCAIP See in Reactome R-HSA-5688837 ( R-HSA-5689877 ) R-HSA-5688837 Reaction Name: ATXN3 deubiquitinates polyUb-PARK2 See in Reactome R-HSA-5689085 ( R-HSA-5689877 ) R-HSA-5689085 Reaction Name: ATXN3 binds polyUb-PARK2 See in Reactome R-HSA-5689111 ( R-HSA-5689877 ) R-HSA-5689111 Reaction Name: PARK2 autoubiquitinates See in Reactome R-HSA-9641089 ( R-HSA-9646399 ) R-HSA-9641089 Reaction Name: Parkin binds Ub:UBE2N:UBE2V1 See in Reactome R-HSA-9641096 ( R-HSA-9646399 ) R-HSA-9641096 Reaction Name: Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub See in Reactome R-HSA-9641109 ( R-HSA-9646399 ) R-HSA-9641109 Reaction Name: PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 See in Reactome R-HSA-9641111 ( R-HSA-9646399 ) R-HSA-9641111 Reaction Name: Parkin transfers Ub to misfolded proteins See in Reactome R-HSA-9641127 ( R-HSA-9646399 ) R-HSA-9641127 Reaction Name: Ub:misfolded proteins polymerize to PolyUb:misfolded proteins See in Reactome R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome
MONDO:0011860	PRKN	O60260	2.3.2.31	R-HSA-5205685 R-HSA-5205685 Reactome Name: PINK1-PRKN Mediated Mitophagy See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-9646399 R-HSA-9646399 Reactome Name: Aggrephagy See in Reactome R-HSA-5689877 R-HSA-5689877 Reactome Name: Josephin domain DUBs See in Reactome R-HSA-977225 R-HSA-977225 Reactome Name: Amyloid fiber formation See in Reactome	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome	Autophagy Immune System Metabolism of proteins	R-HSA-5205652 ( R-HSA-5205685 ) R-HSA-5205652 Reaction Name: Pink1 recruits Parkin to the outer mitochondrial membrane. See in Reactome R-HSA-5205682 ( R-HSA-5205685 ) R-HSA-5205682 Reaction Name: Parkin promotes the ubiquitination of mitochondrial substrates See in Reactome R-HSA-5658574 ( R-HSA-977225 ) R-HSA-5658574 Reaction Name: PARK2 binds SNCAIP See in Reactome R-HSA-5667111 ( R-HSA-977225 ) R-HSA-5667111 Reaction Name: PARK2 K63-Ubiquitinates SNCAIP See in Reactome R-HSA-5688837 ( R-HSA-5689877 ) R-HSA-5688837 Reaction Name: ATXN3 deubiquitinates polyUb-PARK2 See in Reactome R-HSA-5689085 ( R-HSA-5689877 ) R-HSA-5689085 Reaction Name: ATXN3 binds polyUb-PARK2 See in Reactome R-HSA-5689111 ( R-HSA-5689877 ) R-HSA-5689111 Reaction Name: PARK2 autoubiquitinates See in Reactome R-HSA-9641089 ( R-HSA-9646399 ) R-HSA-9641089 Reaction Name: Parkin binds Ub:UBE2N:UBE2V1 See in Reactome R-HSA-9641096 ( R-HSA-9646399 ) R-HSA-9641096 Reaction Name: Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub See in Reactome R-HSA-9641109 ( R-HSA-9646399 ) R-HSA-9641109 Reaction Name: PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 See in Reactome R-HSA-9641111 ( R-HSA-9646399 ) R-HSA-9641111 Reaction Name: Parkin transfers Ub to misfolded proteins See in Reactome R-HSA-9641127 ( R-HSA-9646399 ) R-HSA-9641127 Reaction Name: Ub:misfolded proteins polymerize to PolyUb:misfolded proteins See in Reactome R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome
MONDO:0011951	VCP	P55072	3.6.4.6	R-HSA-3371511 R-HSA-3371511 Reactome Name: HSF1 activation See in Reactome R-HSA-9646399 R-HSA-9646399 Reactome Name: Aggrephagy See in Reactome R-HSA-110320 R-HSA-110320 Reactome Name: Translesion Synthesis by POLH See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-532668 R-HSA-532668 Reactome Name: N-glycan trimming in the ER and Calnexin/Calreticulin cycle See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8876725 R-HSA-8876725 Reactome Name: Protein methylation See in Reactome R-HSA-8866654 R-HSA-8866654 Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins See in Reactome R-HSA-5689877 R-HSA-5689877 Reactome Name: Josephin domain DUBs See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	Immune System Transport of small molecules Cellular responses to stimuli Autophagy Metabolism of proteins DNA Repair Signal Transduction	R-HSA-5324632 ( R-HSA-3371511 ) R-HSA-5324632 Reaction Name: Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates See in Reactome R-HSA-5362412 ( R-HSA-5358346 ) R-HSA-5362412 Reaction Name: SYVN1 ubiquitinates Hh C-terminal fragments See in Reactome R-HSA-5362441 ( R-HSA-5358346 ) R-HSA-5362441 Reaction Name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane See in Reactome R-HSA-5362459 ( R-HSA-5358346 ) R-HSA-5362459 Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol See in Reactome R-HSA-5654985 ( R-HSA-110320 ) R-HSA-5654985 Reaction Name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH See in Reactome R-HSA-5654989 ( R-HSA-110320 ) R-HSA-5654989 Reaction Name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA See in Reactome R-HSA-5688834 ( R-HSA-5689877 ) R-HSA-5688834 Reaction Name: ATXN3 binds VCP See in Reactome R-HSA-6781953 ( R-HSA-5689896 ) R-HSA-6781953 Reaction Name: YOD1 binds VCP See in Reactome R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-8850594 ( R-HSA-532668 ) R-HSA-8850594 Reaction Name: Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins See in Reactome R-HSA-8866542 ( R-HSA-382556 ) R-HSA-8866542 Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol See in Reactome R-HSA-8866546 ( R-HSA-382556 ) R-HSA-8866546 Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR See in Reactome R-HSA-8866551 ( R-HSA-382556 ) R-HSA-8866551 Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation See in Reactome R-HSA-8932276 ( R-HSA-8876725 ) R-HSA-8932276 Reaction Name: VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP See in Reactome R-HSA-8943080 ( R-HSA-8866654 ) R-HSA-8943080 Reaction Name: TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11 See in Reactome R-HSA-8943083 ( R-HSA-8866654 ) R-HSA-8943083 Reaction Name: US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome R-HSA-9646347 ( R-HSA-9646399 ) R-HSA-9646347 Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1 See in Reactome R-HSA-9646354 ( R-HSA-9646399 ) R-HSA-9646354 Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex See in Reactome R-HSA-9755507 () R-HSA-9755507 Reaction Name: UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex See in Reactome R-HSA-9758088 () R-HSA-9758088 Reaction Name: UBXN7 binds VCP hexamer:UBF1:NPLOC4 See in Reactome R-HSA-9758090 () R-HSA-9758090 Reaction Name: Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation See in Reactome
MONDO:0013501	VCP	P55072	3.6.4.6	R-HSA-3371511 R-HSA-3371511 Reactome Name: HSF1 activation See in Reactome R-HSA-9646399 R-HSA-9646399 Reactome Name: Aggrephagy See in Reactome R-HSA-110320 R-HSA-110320 Reactome Name: Translesion Synthesis by POLH See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-532668 R-HSA-532668 Reactome Name: N-glycan trimming in the ER and Calnexin/Calreticulin cycle See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8876725 R-HSA-8876725 Reactome Name: Protein methylation See in Reactome R-HSA-8866654 R-HSA-8866654 Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins See in Reactome R-HSA-5689877 R-HSA-5689877 Reactome Name: Josephin domain DUBs See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	Immune System Transport of small molecules Cellular responses to stimuli Autophagy Metabolism of proteins DNA Repair Signal Transduction	R-HSA-5324632 ( R-HSA-3371511 ) R-HSA-5324632 Reaction Name: Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates See in Reactome R-HSA-5362412 ( R-HSA-5358346 ) R-HSA-5362412 Reaction Name: SYVN1 ubiquitinates Hh C-terminal fragments See in Reactome R-HSA-5362441 ( R-HSA-5358346 ) R-HSA-5362441 Reaction Name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane See in Reactome R-HSA-5362459 ( R-HSA-5358346 ) R-HSA-5362459 Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol See in Reactome R-HSA-5654985 ( R-HSA-110320 ) R-HSA-5654985 Reaction Name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH See in Reactome R-HSA-5654989 ( R-HSA-110320 ) R-HSA-5654989 Reaction Name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA See in Reactome R-HSA-5688834 ( R-HSA-5689877 ) R-HSA-5688834 Reaction Name: ATXN3 binds VCP See in Reactome R-HSA-6781953 ( R-HSA-5689896 ) R-HSA-6781953 Reaction Name: YOD1 binds VCP See in Reactome R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-8850594 ( R-HSA-532668 ) R-HSA-8850594 Reaction Name: Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins See in Reactome R-HSA-8866542 ( R-HSA-382556 ) R-HSA-8866542 Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol See in Reactome R-HSA-8866546 ( R-HSA-382556 ) R-HSA-8866546 Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR See in Reactome R-HSA-8866551 ( R-HSA-382556 ) R-HSA-8866551 Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation See in Reactome R-HSA-8932276 ( R-HSA-8876725 ) R-HSA-8932276 Reaction Name: VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP See in Reactome R-HSA-8943080 ( R-HSA-8866654 ) R-HSA-8943080 Reaction Name: TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11 See in Reactome R-HSA-8943083 ( R-HSA-8866654 ) R-HSA-8943083 Reaction Name: US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome R-HSA-9646347 ( R-HSA-9646399 ) R-HSA-9646347 Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1 See in Reactome R-HSA-9646354 ( R-HSA-9646399 ) R-HSA-9646354 Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex See in Reactome R-HSA-9755507 () R-HSA-9755507 Reaction Name: UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex See in Reactome R-HSA-9758088 () R-HSA-9758088 Reaction Name: UBXN7 binds VCP hexamer:UBF1:NPLOC4 See in Reactome R-HSA-9758090 () R-HSA-9758090 Reaction Name: Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation See in Reactome
MONDO:0014735	VCP	P55072	3.6.4.6	R-HSA-3371511 R-HSA-3371511 Reactome Name: HSF1 activation See in Reactome R-HSA-9646399 R-HSA-9646399 Reactome Name: Aggrephagy See in Reactome R-HSA-110320 R-HSA-110320 Reactome Name: Translesion Synthesis by POLH See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-532668 R-HSA-532668 Reactome Name: N-glycan trimming in the ER and Calnexin/Calreticulin cycle See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8876725 R-HSA-8876725 Reactome Name: Protein methylation See in Reactome R-HSA-8866654 R-HSA-8866654 Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins See in Reactome R-HSA-5689877 R-HSA-5689877 Reactome Name: Josephin domain DUBs See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	Immune System Transport of small molecules Cellular responses to stimuli Autophagy Metabolism of proteins DNA Repair Signal Transduction	R-HSA-5324632 ( R-HSA-3371511 ) R-HSA-5324632 Reaction Name: Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates See in Reactome R-HSA-5362412 ( R-HSA-5358346 ) R-HSA-5362412 Reaction Name: SYVN1 ubiquitinates Hh C-terminal fragments See in Reactome R-HSA-5362441 ( R-HSA-5358346 ) R-HSA-5362441 Reaction Name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane See in Reactome R-HSA-5362459 ( R-HSA-5358346 ) R-HSA-5362459 Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol See in Reactome R-HSA-5654985 ( R-HSA-110320 ) R-HSA-5654985 Reaction Name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH See in Reactome R-HSA-5654989 ( R-HSA-110320 ) R-HSA-5654989 Reaction Name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA See in Reactome R-HSA-5688834 ( R-HSA-5689877 ) R-HSA-5688834 Reaction Name: ATXN3 binds VCP See in Reactome R-HSA-6781953 ( R-HSA-5689896 ) R-HSA-6781953 Reaction Name: YOD1 binds VCP See in Reactome R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-8850594 ( R-HSA-532668 ) R-HSA-8850594 Reaction Name: Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins See in Reactome R-HSA-8866542 ( R-HSA-382556 ) R-HSA-8866542 Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol See in Reactome R-HSA-8866546 ( R-HSA-382556 ) R-HSA-8866546 Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR See in Reactome R-HSA-8866551 ( R-HSA-382556 ) R-HSA-8866551 Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation See in Reactome R-HSA-8932276 ( R-HSA-8876725 ) R-HSA-8932276 Reaction Name: VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP See in Reactome R-HSA-8943080 ( R-HSA-8866654 ) R-HSA-8943080 Reaction Name: TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11 See in Reactome R-HSA-8943083 ( R-HSA-8866654 ) R-HSA-8943083 Reaction Name: US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome R-HSA-9646347 ( R-HSA-9646399 ) R-HSA-9646347 Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1 See in Reactome R-HSA-9646354 ( R-HSA-9646399 ) R-HSA-9646354 Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex See in Reactome R-HSA-9755507 () R-HSA-9755507 Reaction Name: UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex See in Reactome R-HSA-9758088 () R-HSA-9758088 Reaction Name: UBXN7 binds VCP hexamer:UBF1:NPLOC4 See in Reactome R-HSA-9758090 () R-HSA-9758090 Reaction Name: Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation See in Reactome
MONDO:0017174	ATXN3	P54252	3.4.19.12	R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-5689877 R-HSA-5689877 Reactome Name: Josephin domain DUBs See in Reactome	R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of proteins	R-HSA-5688786 ( R-HSA-5689877 ) R-HSA-5688786 Reaction Name: ATXN3 binds RAD23 See in Reactome R-HSA-5688797 ( R-HSA-5689877 ) R-HSA-5688797 Reaction Name: ATXN3 family cleave Ub chains See in Reactome R-HSA-5688834 ( R-HSA-5689877 ) R-HSA-5688834 Reaction Name: ATXN3 binds VCP See in Reactome R-HSA-5688837 ( R-HSA-5689877 ) R-HSA-5688837 Reaction Name: ATXN3 deubiquitinates polyUb-PARK2 See in Reactome R-HSA-5689085 ( R-HSA-5689877 ) R-HSA-5689085 Reaction Name: ATXN3 binds polyUb-PARK2 See in Reactome R-HSA-9617832 ( R-HSA-9615017 ) R-HSA-9617832 Reaction Name: FOXO4:ATXN3 binds SOD2 gene promoter See in Reactome R-HSA-9617833 ( R-HSA-9615017 ) R-HSA-9617833 Reaction Name: SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1 See in Reactome R-HSA-9617927 ( R-HSA-9615017 ) R-HSA-9617927 Reaction Name: FOXO4 binds ATXN3 See in Reactome
MONDO:0017175	ATXN3	P54252	3.4.19.12	R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-5689877 R-HSA-5689877 Reactome Name: Josephin domain DUBs See in Reactome	R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of proteins	R-HSA-5688786 ( R-HSA-5689877 ) R-HSA-5688786 Reaction Name: ATXN3 binds RAD23 See in Reactome R-HSA-5688797 ( R-HSA-5689877 ) R-HSA-5688797 Reaction Name: ATXN3 family cleave Ub chains See in Reactome R-HSA-5688834 ( R-HSA-5689877 ) R-HSA-5688834 Reaction Name: ATXN3 binds VCP See in Reactome R-HSA-5688837 ( R-HSA-5689877 ) R-HSA-5688837 Reaction Name: ATXN3 deubiquitinates polyUb-PARK2 See in Reactome R-HSA-5689085 ( R-HSA-5689877 ) R-HSA-5689085 Reaction Name: ATXN3 binds polyUb-PARK2 See in Reactome R-HSA-9617832 ( R-HSA-9615017 ) R-HSA-9617832 Reaction Name: FOXO4:ATXN3 binds SOD2 gene promoter See in Reactome R-HSA-9617833 ( R-HSA-9615017 ) R-HSA-9617833 Reaction Name: SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1 See in Reactome R-HSA-9617927 ( R-HSA-9615017 ) R-HSA-9617927 Reaction Name: FOXO4 binds ATXN3 See in Reactome
MONDO:0017176	ATXN3	P54252	3.4.19.12	R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-5689877 R-HSA-5689877 Reactome Name: Josephin domain DUBs See in Reactome	R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of proteins	R-HSA-5688786 ( R-HSA-5689877 ) R-HSA-5688786 Reaction Name: ATXN3 binds RAD23 See in Reactome R-HSA-5688797 ( R-HSA-5689877 ) R-HSA-5688797 Reaction Name: ATXN3 family cleave Ub chains See in Reactome R-HSA-5688834 ( R-HSA-5689877 ) R-HSA-5688834 Reaction Name: ATXN3 binds VCP See in Reactome R-HSA-5688837 ( R-HSA-5689877 ) R-HSA-5688837 Reaction Name: ATXN3 deubiquitinates polyUb-PARK2 See in Reactome R-HSA-5689085 ( R-HSA-5689877 ) R-HSA-5689085 Reaction Name: ATXN3 binds polyUb-PARK2 See in Reactome R-HSA-9617832 ( R-HSA-9615017 ) R-HSA-9617832 Reaction Name: FOXO4:ATXN3 binds SOD2 gene promoter See in Reactome R-HSA-9617833 ( R-HSA-9615017 ) R-HSA-9617833 Reaction Name: SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1 See in Reactome R-HSA-9617927 ( R-HSA-9615017 ) R-HSA-9617927 Reaction Name: FOXO4 binds ATXN3 See in Reactome
MONDO:0018005	VCP	P55072	3.6.4.6	R-HSA-3371511 R-HSA-3371511 Reactome Name: HSF1 activation See in Reactome R-HSA-9646399 R-HSA-9646399 Reactome Name: Aggrephagy See in Reactome R-HSA-110320 R-HSA-110320 Reactome Name: Translesion Synthesis by POLH See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-532668 R-HSA-532668 Reactome Name: N-glycan trimming in the ER and Calnexin/Calreticulin cycle See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8876725 R-HSA-8876725 Reactome Name: Protein methylation See in Reactome R-HSA-8866654 R-HSA-8866654 Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins See in Reactome R-HSA-5689877 R-HSA-5689877 Reactome Name: Josephin domain DUBs See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	Immune System Transport of small molecules Cellular responses to stimuli Autophagy Metabolism of proteins DNA Repair Signal Transduction	R-HSA-5324632 ( R-HSA-3371511 ) R-HSA-5324632 Reaction Name: Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates See in Reactome R-HSA-5362412 ( R-HSA-5358346 ) R-HSA-5362412 Reaction Name: SYVN1 ubiquitinates Hh C-terminal fragments See in Reactome R-HSA-5362441 ( R-HSA-5358346 ) R-HSA-5362441 Reaction Name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane See in Reactome R-HSA-5362459 ( R-HSA-5358346 ) R-HSA-5362459 Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol See in Reactome R-HSA-5654985 ( R-HSA-110320 ) R-HSA-5654985 Reaction Name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH See in Reactome R-HSA-5654989 ( R-HSA-110320 ) R-HSA-5654989 Reaction Name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA See in Reactome R-HSA-5688834 ( R-HSA-5689877 ) R-HSA-5688834 Reaction Name: ATXN3 binds VCP See in Reactome R-HSA-6781953 ( R-HSA-5689896 ) R-HSA-6781953 Reaction Name: YOD1 binds VCP See in Reactome R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-8850594 ( R-HSA-532668 ) R-HSA-8850594 Reaction Name: Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins See in Reactome R-HSA-8866542 ( R-HSA-382556 ) R-HSA-8866542 Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol See in Reactome R-HSA-8866546 ( R-HSA-382556 ) R-HSA-8866546 Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR See in Reactome R-HSA-8866551 ( R-HSA-382556 ) R-HSA-8866551 Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation See in Reactome R-HSA-8932276 ( R-HSA-8876725 ) R-HSA-8932276 Reaction Name: VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP See in Reactome R-HSA-8943080 ( R-HSA-8866654 ) R-HSA-8943080 Reaction Name: TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11 See in Reactome R-HSA-8943083 ( R-HSA-8866654 ) R-HSA-8943083 Reaction Name: US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome R-HSA-9646347 ( R-HSA-9646399 ) R-HSA-9646347 Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1 See in Reactome R-HSA-9646354 ( R-HSA-9646399 ) R-HSA-9646354 Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex See in Reactome R-HSA-9755507 () R-HSA-9755507 Reaction Name: UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex See in Reactome R-HSA-9758088 () R-HSA-9758088 Reaction Name: UBXN7 binds VCP hexamer:UBF1:NPLOC4 See in Reactome R-HSA-9758090 () R-HSA-9758090 Reaction Name: Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation See in Reactome
MONDO:0018006	VCP	P55072	3.6.4.6	R-HSA-3371511 R-HSA-3371511 Reactome Name: HSF1 activation See in Reactome R-HSA-9646399 R-HSA-9646399 Reactome Name: Aggrephagy See in Reactome R-HSA-110320 R-HSA-110320 Reactome Name: Translesion Synthesis by POLH See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-532668 R-HSA-532668 Reactome Name: N-glycan trimming in the ER and Calnexin/Calreticulin cycle See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8876725 R-HSA-8876725 Reactome Name: Protein methylation See in Reactome R-HSA-8866654 R-HSA-8866654 Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins See in Reactome R-HSA-5689877 R-HSA-5689877 Reactome Name: Josephin domain DUBs See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	Immune System Transport of small molecules Cellular responses to stimuli Autophagy Metabolism of proteins DNA Repair Signal Transduction	R-HSA-5324632 ( R-HSA-3371511 ) R-HSA-5324632 Reaction Name: Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates See in Reactome R-HSA-5362412 ( R-HSA-5358346 ) R-HSA-5362412 Reaction Name: SYVN1 ubiquitinates Hh C-terminal fragments See in Reactome R-HSA-5362441 ( R-HSA-5358346 ) R-HSA-5362441 Reaction Name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane See in Reactome R-HSA-5362459 ( R-HSA-5358346 ) R-HSA-5362459 Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol See in Reactome R-HSA-5654985 ( R-HSA-110320 ) R-HSA-5654985 Reaction Name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH See in Reactome R-HSA-5654989 ( R-HSA-110320 ) R-HSA-5654989 Reaction Name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA See in Reactome R-HSA-5688834 ( R-HSA-5689877 ) R-HSA-5688834 Reaction Name: ATXN3 binds VCP See in Reactome R-HSA-6781953 ( R-HSA-5689896 ) R-HSA-6781953 Reaction Name: YOD1 binds VCP See in Reactome R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-8850594 ( R-HSA-532668 ) R-HSA-8850594 Reaction Name: Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins See in Reactome R-HSA-8866542 ( R-HSA-382556 ) R-HSA-8866542 Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol See in Reactome R-HSA-8866546 ( R-HSA-382556 ) R-HSA-8866546 Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR See in Reactome R-HSA-8866551 ( R-HSA-382556 ) R-HSA-8866551 Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation See in Reactome R-HSA-8932276 ( R-HSA-8876725 ) R-HSA-8932276 Reaction Name: VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP See in Reactome R-HSA-8943080 ( R-HSA-8866654 ) R-HSA-8943080 Reaction Name: TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11 See in Reactome R-HSA-8943083 ( R-HSA-8866654 ) R-HSA-8943083 Reaction Name: US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome R-HSA-9646347 ( R-HSA-9646399 ) R-HSA-9646347 Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1 See in Reactome R-HSA-9646354 ( R-HSA-9646399 ) R-HSA-9646354 Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex See in Reactome R-HSA-9755507 () R-HSA-9755507 Reaction Name: UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex See in Reactome R-HSA-9758088 () R-HSA-9758088 Reaction Name: UBXN7 binds VCP hexamer:UBF1:NPLOC4 See in Reactome R-HSA-9758090 () R-HSA-9758090 Reaction Name: Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation See in Reactome