MONDO:0001071 |
MONDO:0001071
Disease Name: intellectual disability
Orphanet id: Orphanet:319658
All associated enzymes in DAR:
CYP2U1
DHX16
CBS
POLG
UFSP2
P4HTM
PDIA3
DHX30
TET3
ALG3
NAGLU
CHD3
SMPD1
DHX34
GCH1
CARNMT1
CYP27A1
ABCD1
CHD2
DDX54
INO80
PTPN4
DHX37
INO80 |
Q9ULG1 |
3.6.4.-
|
R-HSA-5689603
R-HSA-5696394
R-HSA-5696394
Reactome Name: DNA Damage Recognition in GG-NER
See in Reactome
|
R-HSA-5696399
R-HSA-5696399
Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER)
See in Reactome
R-HSA-5696398
R-HSA-5688426
R-HSA-392499
R-HSA-73894
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
|
Metabolism of proteins
DNA Repair
|
R-HSA-5689544
(
R-HSA-5689603
)
R-HSA-5691006
(
R-HSA-5696394
)
R-HSA-5691006
Reaction Name: XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site
See in Reactome
|
MONDO:0005580 |
TGFBR2 |
P37173 |
2.7.11.30
|
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-5689603
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
|
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-5688426
R-HSA-392499
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-170835
(
R-HSA-2173789
)
R-HSA-170835
Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
See in Reactome
R-HSA-170843
(
R-HSA-2173789
)
R-HSA-170846
(
R-HSA-2173789
)
R-HSA-170850
(
R-HSA-2173789
)
R-HSA-170850
Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR
See in Reactome
R-HSA-170861
(
R-HSA-2173789
)
R-HSA-170861
Reaction Name: Dimeric TGF-beta-1 binds to the receptor
See in Reactome
R-HSA-170868
(
R-HSA-2173789
)
R-HSA-170868
Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly
See in Reactome
R-HSA-173483
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173483
Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor
See in Reactome
R-HSA-173512
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173512
Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
See in Reactome
R-HSA-178178
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-178218
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178218
Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1
See in Reactome
R-HSA-2127562
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2127562
Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex
See in Reactome
R-HSA-2128994
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2128994
Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-2169046
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169046
Reaction Name: Degradation of TGF-beta receptor complex
See in Reactome
R-HSA-2169050
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169050
Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
See in Reactome
R-HSA-2179291
(
R-HSA-2173788;
R-HSA-2173789;
R-HSA-5689603
)
R-HSA-2179291
Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1
See in Reactome
R-HSA-2179293
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2179293
Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1
See in Reactome
R-HSA-4332235
(
R-HSA-2173789
)
R-HSA-4332236
(
R-HSA-2173789
)
|
MONDO:0006292 |
BAP1 |
Q92560 |
3.4.19.12
|
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5689603
|
R-HSA-5688426
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-392499
R-HSA-73894
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
|
Metabolism of proteins
DNA Repair
|
R-HSA-5689630
(
R-HSA-5689603
)
R-HSA-5689630
Reaction Name: BAP1 binds BAP1-interacting complex
See in Reactome
R-HSA-5689649
(
R-HSA-5689603
)
R-HSA-5690759
(
R-HSA-5689603
)
R-HSA-5690759
Reaction Name: BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1
See in Reactome
R-HSA-5690785
(
R-HSA-5689603
)
R-HSA-5690790
(
R-HSA-5689603
)
R-HSA-5690790
Reaction Name: Histone H2A is dubiquitinated by the PR-DUB complex
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
MONDO:0006486 |
MONDO:0006486
Disease Name: uveal melanoma
OMIM id: OMIM:606661
Orphanet id: Orphanet:39044
All associated enzymes in DAR:
BAP1
. The disease is also associated to other non-enzyme proteins (not in DAR).
BAP1 |
Q92560 |
3.4.19.12
|
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5689603
|
R-HSA-5688426
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-392499
R-HSA-73894
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
|
Metabolism of proteins
DNA Repair
|
R-HSA-5689630
(
R-HSA-5689603
)
R-HSA-5689630
Reaction Name: BAP1 binds BAP1-interacting complex
See in Reactome
R-HSA-5689649
(
R-HSA-5689603
)
R-HSA-5690759
(
R-HSA-5689603
)
R-HSA-5690759
Reaction Name: BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1
See in Reactome
R-HSA-5690785
(
R-HSA-5689603
)
R-HSA-5690790
(
R-HSA-5689603
)
R-HSA-5690790
Reaction Name: Histone H2A is dubiquitinated by the PR-DUB complex
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
MONDO:0007522 |
TGFBR1 |
P36897 |
2.7.11.30
|
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5689603
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
|
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-5688426
R-HSA-392499
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-170835
(
R-HSA-2173789
)
R-HSA-170835
Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
See in Reactome
R-HSA-170843
(
R-HSA-2173789
)
R-HSA-170846
(
R-HSA-2173789
)
R-HSA-170850
(
R-HSA-2173789
)
R-HSA-170850
Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR
See in Reactome
R-HSA-170868
(
R-HSA-2173789
)
R-HSA-170868
Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly
See in Reactome
R-HSA-173483
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173483
Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor
See in Reactome
R-HSA-173512
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173512
Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
See in Reactome
R-HSA-178178
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-178218
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178218
Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1
See in Reactome
R-HSA-2127562
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2127562
Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex
See in Reactome
R-HSA-2128994
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2128994
Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-2169046
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169046
Reaction Name: Degradation of TGF-beta receptor complex
See in Reactome
R-HSA-2169050
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169050
Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
See in Reactome
R-HSA-2179291
(
R-HSA-2173788;
R-HSA-2173789;
R-HSA-5689603
)
R-HSA-2179291
Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1
See in Reactome
R-HSA-2179293
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2179293
Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1
See in Reactome
R-HSA-6781764
(
R-HSA-5689880
)
R-HSA-6781764
Reaction Name: USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1
See in Reactome
|
MONDO:0007566 |
TGFBR1 |
P36897 |
2.7.11.30
|
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5689603
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
|
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-5688426
R-HSA-392499
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-170835
(
R-HSA-2173789
)
R-HSA-170835
Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
See in Reactome
R-HSA-170843
(
R-HSA-2173789
)
R-HSA-170846
(
R-HSA-2173789
)
R-HSA-170850
(
R-HSA-2173789
)
R-HSA-170850
Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR
See in Reactome
R-HSA-170868
(
R-HSA-2173789
)
R-HSA-170868
Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly
See in Reactome
R-HSA-173483
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173483
Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor
See in Reactome
R-HSA-173512
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173512
Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
See in Reactome
R-HSA-178178
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-178218
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178218
Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1
See in Reactome
R-HSA-2127562
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2127562
Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex
See in Reactome
R-HSA-2128994
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2128994
Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-2169046
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169046
Reaction Name: Degradation of TGF-beta receptor complex
See in Reactome
R-HSA-2169050
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169050
Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
See in Reactome
R-HSA-2179291
(
R-HSA-2173788;
R-HSA-2173789;
R-HSA-5689603
)
R-HSA-2179291
Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1
See in Reactome
R-HSA-2179293
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2179293
Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1
See in Reactome
R-HSA-6781764
(
R-HSA-5689880
)
R-HSA-6781764
Reaction Name: USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1
See in Reactome
|
MONDO:0007947 |
TGFBR1 |
P36897 |
2.7.11.30
|
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5689603
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
|
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-5688426
R-HSA-392499
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-170835
(
R-HSA-2173789
)
R-HSA-170835
Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
See in Reactome
R-HSA-170843
(
R-HSA-2173789
)
R-HSA-170846
(
R-HSA-2173789
)
R-HSA-170850
(
R-HSA-2173789
)
R-HSA-170850
Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR
See in Reactome
R-HSA-170868
(
R-HSA-2173789
)
R-HSA-170868
Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly
See in Reactome
R-HSA-173483
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173483
Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor
See in Reactome
R-HSA-173512
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173512
Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
See in Reactome
R-HSA-178178
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-178218
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178218
Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1
See in Reactome
R-HSA-2127562
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2127562
Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex
See in Reactome
R-HSA-2128994
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2128994
Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-2169046
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169046
Reaction Name: Degradation of TGF-beta receptor complex
See in Reactome
R-HSA-2169050
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169050
Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
See in Reactome
R-HSA-2179291
(
R-HSA-2173788;
R-HSA-2173789;
R-HSA-5689603
)
R-HSA-2179291
Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1
See in Reactome
R-HSA-2179293
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2179293
Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1
See in Reactome
R-HSA-6781764
(
R-HSA-5689880
)
R-HSA-6781764
Reaction Name: USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1
See in Reactome
|
MONDO:0007947 |
TGFBR2 |
P37173 |
2.7.11.30
|
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-5689603
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
|
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-5688426
R-HSA-392499
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-170835
(
R-HSA-2173789
)
R-HSA-170835
Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
See in Reactome
R-HSA-170843
(
R-HSA-2173789
)
R-HSA-170846
(
R-HSA-2173789
)
R-HSA-170850
(
R-HSA-2173789
)
R-HSA-170850
Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR
See in Reactome
R-HSA-170861
(
R-HSA-2173789
)
R-HSA-170861
Reaction Name: Dimeric TGF-beta-1 binds to the receptor
See in Reactome
R-HSA-170868
(
R-HSA-2173789
)
R-HSA-170868
Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly
See in Reactome
R-HSA-173483
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173483
Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor
See in Reactome
R-HSA-173512
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173512
Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
See in Reactome
R-HSA-178178
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-178218
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178218
Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1
See in Reactome
R-HSA-2127562
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2127562
Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex
See in Reactome
R-HSA-2128994
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2128994
Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-2169046
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169046
Reaction Name: Degradation of TGF-beta receptor complex
See in Reactome
R-HSA-2169050
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169050
Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
See in Reactome
R-HSA-2179291
(
R-HSA-2173788;
R-HSA-2173789;
R-HSA-5689603
)
R-HSA-2179291
Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1
See in Reactome
R-HSA-2179293
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2179293
Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1
See in Reactome
R-HSA-4332235
(
R-HSA-2173789
)
R-HSA-4332236
(
R-HSA-2173789
)
|
MONDO:0008170 |
BARD1 |
Q99728 |
2.3.2.27
|
R-HSA-5689901
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-5689603
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-69473
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-69481
R-HSA-212436
R-HSA-74160
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-5693538
R-HSA-392499
R-HSA-69620
R-HSA-73894
R-HSA-5688426
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
R-HSA-73857
|
Gene expression (Transcription)
Metabolism of proteins
DNA Repair
Cell Cycle
|
R-HSA-5659781
(
R-HSA-5693565
)
R-HSA-5659781
Reaction Name: BRCA1 forms a heterodimer with BARD1
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473;
R-HSA-69481
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5689649
(
R-HSA-5689603
)
R-HSA-5691411
(
R-HSA-5689901
)
R-HSA-5691411
Reaction Name: BRCA1-A complex deubiquitinates K63polyUb-histone H2A
See in Reactome
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473;
R-HSA-69481
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473;
R-HSA-69481
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9707051
(
R-HSA-5693565
)
R-HSA-9707051
Reaction Name: UBXN1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
MONDO:0009693 |
BAP1 |
Q92560 |
3.4.19.12
|
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5689603
|
R-HSA-5688426
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-392499
R-HSA-73894
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
|
Metabolism of proteins
DNA Repair
|
R-HSA-5689630
(
R-HSA-5689603
)
R-HSA-5689630
Reaction Name: BAP1 binds BAP1-interacting complex
See in Reactome
R-HSA-5689649
(
R-HSA-5689603
)
R-HSA-5690759
(
R-HSA-5689603
)
R-HSA-5690759
Reaction Name: BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1
See in Reactome
R-HSA-5690785
(
R-HSA-5689603
)
R-HSA-5690790
(
R-HSA-5689603
)
R-HSA-5690790
Reaction Name: Histone H2A is dubiquitinated by the PR-DUB complex
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
MONDO:0012212 |
TGFBR1 |
P36897 |
2.7.11.30
|
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5689603
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
|
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-5688426
R-HSA-392499
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-170835
(
R-HSA-2173789
)
R-HSA-170835
Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
See in Reactome
R-HSA-170843
(
R-HSA-2173789
)
R-HSA-170846
(
R-HSA-2173789
)
R-HSA-170850
(
R-HSA-2173789
)
R-HSA-170850
Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR
See in Reactome
R-HSA-170868
(
R-HSA-2173789
)
R-HSA-170868
Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly
See in Reactome
R-HSA-173483
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173483
Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor
See in Reactome
R-HSA-173512
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173512
Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
See in Reactome
R-HSA-178178
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-178218
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178218
Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1
See in Reactome
R-HSA-2127562
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2127562
Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex
See in Reactome
R-HSA-2128994
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2128994
Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-2169046
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169046
Reaction Name: Degradation of TGF-beta receptor complex
See in Reactome
R-HSA-2169050
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169050
Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
See in Reactome
R-HSA-2179291
(
R-HSA-2173788;
R-HSA-2173789;
R-HSA-5689603
)
R-HSA-2179291
Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1
See in Reactome
R-HSA-2179293
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2179293
Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1
See in Reactome
R-HSA-6781764
(
R-HSA-5689880
)
R-HSA-6781764
Reaction Name: USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1
See in Reactome
|
MONDO:0012212 |
TGFBR2 |
P37173 |
2.7.11.30
|
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-5689603
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
|
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-5688426
R-HSA-392499
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-170835
(
R-HSA-2173789
)
R-HSA-170835
Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
See in Reactome
R-HSA-170843
(
R-HSA-2173789
)
R-HSA-170846
(
R-HSA-2173789
)
R-HSA-170850
(
R-HSA-2173789
)
R-HSA-170850
Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR
See in Reactome
R-HSA-170861
(
R-HSA-2173789
)
R-HSA-170861
Reaction Name: Dimeric TGF-beta-1 binds to the receptor
See in Reactome
R-HSA-170868
(
R-HSA-2173789
)
R-HSA-170868
Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly
See in Reactome
R-HSA-173483
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173483
Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor
See in Reactome
R-HSA-173512
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173512
Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
See in Reactome
R-HSA-178178
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-178218
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178218
Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1
See in Reactome
R-HSA-2127562
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2127562
Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex
See in Reactome
R-HSA-2128994
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2128994
Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-2169046
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169046
Reaction Name: Degradation of TGF-beta receptor complex
See in Reactome
R-HSA-2169050
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169050
Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
See in Reactome
R-HSA-2179291
(
R-HSA-2173788;
R-HSA-2173789;
R-HSA-5689603
)
R-HSA-2179291
Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1
See in Reactome
R-HSA-2179293
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2179293
Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1
See in Reactome
R-HSA-4332235
(
R-HSA-2173789
)
R-HSA-4332236
(
R-HSA-2173789
)
|
MONDO:0012427 |
TGFBR2 |
P37173 |
2.7.11.30
|
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-5689603
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
|
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-5688426
R-HSA-392499
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-170835
(
R-HSA-2173789
)
R-HSA-170835
Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
See in Reactome
R-HSA-170843
(
R-HSA-2173789
)
R-HSA-170846
(
R-HSA-2173789
)
R-HSA-170850
(
R-HSA-2173789
)
R-HSA-170850
Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR
See in Reactome
R-HSA-170861
(
R-HSA-2173789
)
R-HSA-170861
Reaction Name: Dimeric TGF-beta-1 binds to the receptor
See in Reactome
R-HSA-170868
(
R-HSA-2173789
)
R-HSA-170868
Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly
See in Reactome
R-HSA-173483
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173483
Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor
See in Reactome
R-HSA-173512
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173512
Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
See in Reactome
R-HSA-178178
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-178218
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178218
Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1
See in Reactome
R-HSA-2127562
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2127562
Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex
See in Reactome
R-HSA-2128994
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2128994
Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-2169046
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169046
Reaction Name: Degradation of TGF-beta receptor complex
See in Reactome
R-HSA-2169050
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169050
Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
See in Reactome
R-HSA-2179291
(
R-HSA-2173788;
R-HSA-2173789;
R-HSA-5689603
)
R-HSA-2179291
Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1
See in Reactome
R-HSA-2179293
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2179293
Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1
See in Reactome
R-HSA-4332235
(
R-HSA-2173789
)
R-HSA-4332236
(
R-HSA-2173789
)
|
MONDO:0013340 |
UCHL1 |
P09936 |
3.4.19.12
|
R-HSA-5689603
|
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5688426
R-HSA-392499
|
Metabolism of proteins
|
R-HSA-5690319
(
R-HSA-5689603
)
R-HSA-5690319
Reaction Name: UCHL1, UCHL3 cleave ubiquitin adducts
See in Reactome
|
MONDO:0013692 |
BAP1 |
Q92560 |
3.4.19.12
|
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5689603
|
R-HSA-5688426
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-392499
R-HSA-73894
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
|
Metabolism of proteins
DNA Repair
|
R-HSA-5689630
(
R-HSA-5689603
)
R-HSA-5689630
Reaction Name: BAP1 binds BAP1-interacting complex
See in Reactome
R-HSA-5689649
(
R-HSA-5689603
)
R-HSA-5690759
(
R-HSA-5689603
)
R-HSA-5690759
Reaction Name: BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1
See in Reactome
R-HSA-5690785
(
R-HSA-5689603
)
R-HSA-5690790
(
R-HSA-5689603
)
R-HSA-5690790
Reaction Name: Histone H2A is dubiquitinated by the PR-DUB complex
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
MONDO:0013695 |
TGFBR2 |
P37173 |
2.7.11.30
|
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-5689603
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
|
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-5688426
R-HSA-392499
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-170835
(
R-HSA-2173789
)
R-HSA-170835
Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
See in Reactome
R-HSA-170843
(
R-HSA-2173789
)
R-HSA-170846
(
R-HSA-2173789
)
R-HSA-170850
(
R-HSA-2173789
)
R-HSA-170850
Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR
See in Reactome
R-HSA-170861
(
R-HSA-2173789
)
R-HSA-170861
Reaction Name: Dimeric TGF-beta-1 binds to the receptor
See in Reactome
R-HSA-170868
(
R-HSA-2173789
)
R-HSA-170868
Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly
See in Reactome
R-HSA-173483
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173483
Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor
See in Reactome
R-HSA-173512
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173512
Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
See in Reactome
R-HSA-178178
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-178218
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178218
Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1
See in Reactome
R-HSA-2127562
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2127562
Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex
See in Reactome
R-HSA-2128994
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2128994
Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-2169046
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169046
Reaction Name: Degradation of TGF-beta receptor complex
See in Reactome
R-HSA-2169050
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169050
Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
See in Reactome
R-HSA-2179291
(
R-HSA-2173788;
R-HSA-2173789;
R-HSA-5689603
)
R-HSA-2179291
Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1
See in Reactome
R-HSA-2179293
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2179293
Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1
See in Reactome
R-HSA-4332235
(
R-HSA-2173789
)
R-HSA-4332236
(
R-HSA-2173789
)
|
MONDO:0014209 |
UCHL1 |
P09936 |
3.4.19.12
|
R-HSA-5689603
|
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5688426
R-HSA-392499
|
Metabolism of proteins
|
R-HSA-5690319
(
R-HSA-5689603
)
R-HSA-5690319
Reaction Name: UCHL1, UCHL3 cleave ubiquitin adducts
See in Reactome
|
MONDO:0015356 |
BARD1 |
Q99728 |
2.3.2.27
|
R-HSA-5689901
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-5689603
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-69473
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-69481
R-HSA-212436
R-HSA-74160
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-5693538
R-HSA-392499
R-HSA-69620
R-HSA-73894
R-HSA-5688426
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
R-HSA-73857
|
Gene expression (Transcription)
Metabolism of proteins
DNA Repair
Cell Cycle
|
R-HSA-5659781
(
R-HSA-5693565
)
R-HSA-5659781
Reaction Name: BRCA1 forms a heterodimer with BARD1
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473;
R-HSA-69481
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5689649
(
R-HSA-5689603
)
R-HSA-5691411
(
R-HSA-5689901
)
R-HSA-5691411
Reaction Name: BRCA1-A complex deubiquitinates K63polyUb-histone H2A
See in Reactome
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473;
R-HSA-69481
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473;
R-HSA-69481
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9707051
(
R-HSA-5693565
)
R-HSA-9707051
Reaction Name: UBXN1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
MONDO:0016419 |
BARD1 |
Q99728 |
2.3.2.27
|
R-HSA-5689901
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-5689603
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-69473
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-69481
R-HSA-212436
R-HSA-74160
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-5693538
R-HSA-392499
R-HSA-69620
R-HSA-73894
R-HSA-5688426
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
R-HSA-73857
|
Gene expression (Transcription)
Metabolism of proteins
DNA Repair
Cell Cycle
|
R-HSA-5659781
(
R-HSA-5693565
)
R-HSA-5659781
Reaction Name: BRCA1 forms a heterodimer with BARD1
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473;
R-HSA-69481
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5689649
(
R-HSA-5689603
)
R-HSA-5691411
(
R-HSA-5689901
)
R-HSA-5691411
Reaction Name: BRCA1-A complex deubiquitinates K63polyUb-histone H2A
See in Reactome
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473;
R-HSA-69481
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473;
R-HSA-69481
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9707051
(
R-HSA-5693565
)
R-HSA-9707051
Reaction Name: UBXN1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
MONDO:0016642 |
BAP1 |
Q92560 |
3.4.19.12
|
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5689603
|
R-HSA-5688426
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-392499
R-HSA-73894
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
|
Metabolism of proteins
DNA Repair
|
R-HSA-5689630
(
R-HSA-5689603
)
R-HSA-5689630
Reaction Name: BAP1 binds BAP1-interacting complex
See in Reactome
R-HSA-5689649
(
R-HSA-5689603
)
R-HSA-5690759
(
R-HSA-5689603
)
R-HSA-5690759
Reaction Name: BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1
See in Reactome
R-HSA-5690785
(
R-HSA-5689603
)
R-HSA-5690790
(
R-HSA-5689603
)
R-HSA-5690790
Reaction Name: Histone H2A is dubiquitinated by the PR-DUB complex
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
MONDO:0019438 |
BAP1 |
Q92560 |
3.4.19.12
|
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5689603
|
R-HSA-5688426
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-392499
R-HSA-73894
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
|
Metabolism of proteins
DNA Repair
|
R-HSA-5689630
(
R-HSA-5689603
)
R-HSA-5689630
Reaction Name: BAP1 binds BAP1-interacting complex
See in Reactome
R-HSA-5689649
(
R-HSA-5689603
)
R-HSA-5690759
(
R-HSA-5689603
)
R-HSA-5690759
Reaction Name: BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1
See in Reactome
R-HSA-5690785
(
R-HSA-5689603
)
R-HSA-5690790
(
R-HSA-5689603
)
R-HSA-5690790
Reaction Name: Histone H2A is dubiquitinated by the PR-DUB complex
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
MONDO:0019625 |
TGFBR1 |
P36897 |
2.7.11.30
|
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5689603
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
|
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-5688426
R-HSA-392499
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-170835
(
R-HSA-2173789
)
R-HSA-170835
Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
See in Reactome
R-HSA-170843
(
R-HSA-2173789
)
R-HSA-170846
(
R-HSA-2173789
)
R-HSA-170850
(
R-HSA-2173789
)
R-HSA-170850
Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR
See in Reactome
R-HSA-170868
(
R-HSA-2173789
)
R-HSA-170868
Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly
See in Reactome
R-HSA-173483
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173483
Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor
See in Reactome
R-HSA-173512
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173512
Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
See in Reactome
R-HSA-178178
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-178218
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178218
Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1
See in Reactome
R-HSA-2127562
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2127562
Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex
See in Reactome
R-HSA-2128994
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2128994
Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-2169046
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169046
Reaction Name: Degradation of TGF-beta receptor complex
See in Reactome
R-HSA-2169050
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169050
Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
See in Reactome
R-HSA-2179291
(
R-HSA-2173788;
R-HSA-2173789;
R-HSA-5689603
)
R-HSA-2179291
Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1
See in Reactome
R-HSA-2179293
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2179293
Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1
See in Reactome
R-HSA-6781764
(
R-HSA-5689880
)
R-HSA-6781764
Reaction Name: USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1
See in Reactome
|
MONDO:0019625 |
TGFBR2 |
P37173 |
2.7.11.30
|
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-5689603
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
|
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-5688426
R-HSA-392499
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-170835
(
R-HSA-2173789
)
R-HSA-170835
Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
See in Reactome
R-HSA-170843
(
R-HSA-2173789
)
R-HSA-170846
(
R-HSA-2173789
)
R-HSA-170850
(
R-HSA-2173789
)
R-HSA-170850
Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR
See in Reactome
R-HSA-170861
(
R-HSA-2173789
)
R-HSA-170861
Reaction Name: Dimeric TGF-beta-1 binds to the receptor
See in Reactome
R-HSA-170868
(
R-HSA-2173789
)
R-HSA-170868
Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly
See in Reactome
R-HSA-173483
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173483
Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor
See in Reactome
R-HSA-173512
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173512
Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
See in Reactome
R-HSA-178178
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-178218
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178218
Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1
See in Reactome
R-HSA-2127562
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2127562
Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex
See in Reactome
R-HSA-2128994
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2128994
Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-2169046
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169046
Reaction Name: Degradation of TGF-beta receptor complex
See in Reactome
R-HSA-2169050
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169050
Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
See in Reactome
R-HSA-2179291
(
R-HSA-2173788;
R-HSA-2173789;
R-HSA-5689603
)
R-HSA-2179291
Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1
See in Reactome
R-HSA-2179293
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2179293
Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1
See in Reactome
R-HSA-4332235
(
R-HSA-2173789
)
R-HSA-4332236
(
R-HSA-2173789
)
|
MONDO:0030907 |
OGT |
O15294 |
2.4.1.255
|
R-HSA-3214847
R-HSA-5213460
R-HSA-5213460
Reactome Name: RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-5689603
R-HSA-5675482
R-HSA-5675482
Reactome Name: Regulation of necroptotic cell death
See in Reactome
|
R-HSA-5688426
R-HSA-392499
R-HSA-5218859
R-HSA-5357801
R-HSA-4839726
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-3247509
|
Metabolism of proteins
Programmed Cell Death
Chromatin organization
|
R-HSA-3321805
(
R-HSA-3214847
)
R-HSA-5213462
(
R-HSA-5213460
)
R-HSA-5689630
(
R-HSA-5689603
)
R-HSA-5689630
Reaction Name: BAP1 binds BAP1-interacting complex
See in Reactome
R-HSA-9687828
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9687828
Reaction Name: O-GlcNAcylation of RIPK3 (TLR4 signaling)
See in Reactome
|
MONDO:0030924 |
PSMB10 |
P40306 |
3.4.25.1
|
R-HSA-8951664
R-HSA-4608870
R-HSA-4608870
Reactome Name: Asymmetric localization of PCP proteins
See in Reactome
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-8852276
R-HSA-8852276
Reactome Name: The role of GTSE1 in G2/M progression after G2 checkpoint
See in Reactome
R-HSA-8941858
R-HSA-8941858
Reactome Name: Regulation of RUNX3 expression and activity
See in Reactome
R-HSA-174184
R-HSA-174184
Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A
See in Reactome
R-HSA-69017
R-HSA-69017
Reactome Name: CDK-mediated phosphorylation and removal of Cdc6
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-187577
R-HSA-187577
Reactome Name: SCF(Skp2)-mediated degradation of p27/p21
See in Reactome
R-HSA-1236978
R-HSA-1236978
Reactome Name: Cross-presentation of soluble exogenous antigens (endosomes)
See in Reactome
R-HSA-5610780
R-HSA-5610780
Reactome Name: Degradation of GLI1 by the proteasome
See in Reactome
R-HSA-5610785
R-HSA-5610785
Reactome Name: GLI3 is processed to GLI3R by the proteasome
See in Reactome
R-HSA-8854050
R-HSA-8854050
Reactome Name: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
See in Reactome
R-HSA-69601
R-HSA-69601
Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
See in Reactome
R-HSA-1236974
R-HSA-5610783
R-HSA-5610783
Reactome Name: Degradation of GLI2 by the proteasome
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5668541
R-HSA-5668541
Reactome Name: TNFR2 non-canonical NF-kB pathway
See in Reactome
R-HSA-1169091
R-HSA-1169091
Reactome Name: Activation of NF-kappaB in B cells
See in Reactome
R-HSA-4641258
R-HSA-9010553
R-HSA-9010553
Reactome Name: Regulation of expression of SLITs and ROBOs
See in Reactome
R-HSA-202424
R-HSA-450408
R-HSA-450408
Reactome Name: AUF1 (hnRNP D0) binds and destabilizes mRNA
See in Reactome
R-HSA-5687128
R-HSA-5676590
R-HSA-5676590
Reactome Name: NIK-->noncanonical NF-kB signaling
See in Reactome
R-HSA-1234176
R-HSA-1234176
Reactome Name: Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
See in Reactome
R-HSA-211733
R-HSA-211733
Reactome Name: Regulation of activated PAK-2p34 by proteasome mediated degradation
See in Reactome
R-HSA-4641257
R-HSA-5607761
R-HSA-5607761
Reactome Name: Dectin-1 mediated noncanonical NF-kB signaling
See in Reactome
R-HSA-5358346
R-HSA-5607764
R-HSA-8939236
R-HSA-8939236
Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs
See in Reactome
R-HSA-174178
R-HSA-174178
Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
See in Reactome
R-HSA-8939902
R-HSA-8939902
Reactome Name: Regulation of RUNX2 expression and activity
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-68949
R-HSA-69481
R-HSA-5658442
R-HSA-174154
R-HSA-174154
Reactome Name: APC/C:Cdc20 mediated degradation of Securin
See in Reactome
R-HSA-195253
R-HSA-195253
Reactome Name: Degradation of beta-catenin by the destruction complex
See in Reactome
R-HSA-174084
R-HSA-174084
Reactome Name: Autodegradation of Cdh1 by Cdh1:APC/C
See in Reactome
R-HSA-174113
R-HSA-174113
Reactome Name: SCF-beta-TrCP mediated degradation of Emi1
See in Reactome
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
R-HSA-350562
R-HSA-350562
Reactome Name: Regulation of ornithine decarboxylase (ODC)
See in Reactome
R-HSA-5632684
R-HSA-5689603
R-HSA-75815
R-HSA-75815
Reactome Name: Ubiquitin-dependent degradation of Cyclin D
See in Reactome
R-HSA-9020702
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-376176
R-HSA-449147
R-HSA-8953897
R-HSA-5688426
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-9013694
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-5358351
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5684996
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-174143
R-HSA-174143
Reactome Name: APC/C-mediated degradation of cell cycle proteins
See in Reactome
R-HSA-69052
R-HSA-69052
Reactome Name: Switching of origins to a post-replicative state
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-4086400
R-HSA-212436
R-HSA-74160
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-1234174
R-HSA-69278
R-HSA-69541
R-HSA-382551
R-HSA-382551
Reactome Name: Transport of small molecules
|