| MONDO:0001071 |
MONDO:0001071
Disease Name: intellectual disability
Orphanet id: Orphanet:319658
All associated enzymes in DAR:
CYP2U1
DHX16
CBS
POLG
UFSP2
P4HTM
PDIA3
DHX30
TET3
ALG3
NAGLU
CHD3
SMPD1
DHX34
GCH1
CARNMT1
CYP27A1
ABCD1
CHD2
DDX54
INO80
PTPN4
DHX37
INO80 |
Q9ULG1 |
3.6.4.-
|
R-HSA-5689603
R-HSA-5696394
R-HSA-5696394
Reactome Name: DNA Damage Recognition in GG-NER
See in Reactome
|
R-HSA-5696399
R-HSA-5696399
Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER)
See in Reactome
R-HSA-5696398
R-HSA-5688426
R-HSA-392499
R-HSA-73894
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
|
Metabolism of proteins
DNA Repair
|
R-HSA-5689544
(
R-HSA-5689603
)
R-HSA-5691006
(
R-HSA-5696394
)
R-HSA-5691006
Reaction Name: XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site
See in Reactome
|
| MONDO:0005580 |
TGFBR2 |
P37173 |
2.7.11.30
|
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-5689603
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
|
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-5688426
R-HSA-392499
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-170835
(
R-HSA-2173789
)
R-HSA-170835
Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
See in Reactome
R-HSA-170843
(
R-HSA-2173789
)
R-HSA-170846
(
R-HSA-2173789
)
R-HSA-170850
(
R-HSA-2173789
)
R-HSA-170850
Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR
See in Reactome
R-HSA-170861
(
R-HSA-2173789
)
R-HSA-170861
Reaction Name: Dimeric TGF-beta-1 binds to the receptor
See in Reactome
R-HSA-170868
(
R-HSA-2173789
)
R-HSA-170868
Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly
See in Reactome
R-HSA-173483
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173483
Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor
See in Reactome
R-HSA-173512
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173512
Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
See in Reactome
R-HSA-178178
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-178218
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178218
Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1
See in Reactome
R-HSA-2127562
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2127562
Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex
See in Reactome
R-HSA-2128994
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2128994
Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-2169046
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169046
Reaction Name: Degradation of TGF-beta receptor complex
See in Reactome
R-HSA-2169050
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169050
Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
See in Reactome
R-HSA-2179291
(
R-HSA-2173788;
R-HSA-2173789;
R-HSA-5689603
)
R-HSA-2179291
Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1
See in Reactome
R-HSA-2179293
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2179293
Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1
See in Reactome
R-HSA-4332235
(
R-HSA-2173789
)
R-HSA-4332236
(
R-HSA-2173789
)
|
| MONDO:0006292 |
BAP1 |
Q92560 |
3.4.19.12
|
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5689603
|
R-HSA-5688426
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-392499
R-HSA-73894
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
|
Metabolism of proteins
DNA Repair
|
R-HSA-5689630
(
R-HSA-5689603
)
R-HSA-5689630
Reaction Name: BAP1 binds BAP1-interacting complex
See in Reactome
R-HSA-5689649
(
R-HSA-5689603
)
R-HSA-5690759
(
R-HSA-5689603
)
R-HSA-5690759
Reaction Name: BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1
See in Reactome
R-HSA-5690785
(
R-HSA-5689603
)
R-HSA-5690790
(
R-HSA-5689603
)
R-HSA-5690790
Reaction Name: Histone H2A is dubiquitinated by the PR-DUB complex
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
| MONDO:0006486 |
MONDO:0006486
Disease Name: uveal melanoma
OMIM id: OMIM:606661
Orphanet id: Orphanet:39044
All associated enzymes in DAR:
BAP1
. The disease is also associated to other non-enzyme proteins (not in DAR).
BAP1 |
Q92560 |
3.4.19.12
|
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5689603
|
R-HSA-5688426
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-392499
R-HSA-73894
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
|
Metabolism of proteins
DNA Repair
|
R-HSA-5689630
(
R-HSA-5689603
)
R-HSA-5689630
Reaction Name: BAP1 binds BAP1-interacting complex
See in Reactome
R-HSA-5689649
(
R-HSA-5689603
)
R-HSA-5690759
(
R-HSA-5689603
)
R-HSA-5690759
Reaction Name: BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1
See in Reactome
R-HSA-5690785
(
R-HSA-5689603
)
R-HSA-5690790
(
R-HSA-5689603
)
R-HSA-5690790
Reaction Name: Histone H2A is dubiquitinated by the PR-DUB complex
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
| MONDO:0007522 |
TGFBR1 |
P36897 |
2.7.11.30
|
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5689603
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
|
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-5688426
R-HSA-392499
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-170835
(
R-HSA-2173789
)
R-HSA-170835
Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
See in Reactome
R-HSA-170843
(
R-HSA-2173789
)
R-HSA-170846
(
R-HSA-2173789
)
R-HSA-170850
(
R-HSA-2173789
)
R-HSA-170850
Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR
See in Reactome
R-HSA-170868
(
R-HSA-2173789
)
R-HSA-170868
Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly
See in Reactome
R-HSA-173483
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173483
Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor
See in Reactome
R-HSA-173512
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173512
Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
See in Reactome
R-HSA-178178
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-178218
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178218
Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1
See in Reactome
R-HSA-2127562
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2127562
Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex
See in Reactome
R-HSA-2128994
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2128994
Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-2169046
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169046
Reaction Name: Degradation of TGF-beta receptor complex
See in Reactome
R-HSA-2169050
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169050
Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
See in Reactome
R-HSA-2179291
(
R-HSA-2173788;
R-HSA-2173789;
R-HSA-5689603
)
R-HSA-2179291
Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1
See in Reactome
R-HSA-2179293
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2179293
Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1
See in Reactome
R-HSA-6781764
(
R-HSA-5689880
)
R-HSA-6781764
Reaction Name: USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1
See in Reactome
|
| MONDO:0007566 |
TGFBR1 |
P36897 |
2.7.11.30
|
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5689603
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
|
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-5688426
R-HSA-392499
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-170835
(
R-HSA-2173789
)
R-HSA-170835
Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
See in Reactome
R-HSA-170843
(
R-HSA-2173789
)
R-HSA-170846
(
R-HSA-2173789
)
R-HSA-170850
(
R-HSA-2173789
)
R-HSA-170850
Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR
See in Reactome
R-HSA-170868
(
R-HSA-2173789
)
R-HSA-170868
Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly
See in Reactome
R-HSA-173483
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173483
Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor
See in Reactome
R-HSA-173512
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173512
Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
See in Reactome
R-HSA-178178
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-178218
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178218
Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1
See in Reactome
R-HSA-2127562
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2127562
Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex
See in Reactome
R-HSA-2128994
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2128994
Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-2169046
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169046
Reaction Name: Degradation of TGF-beta receptor complex
See in Reactome
R-HSA-2169050
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169050
Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
See in Reactome
R-HSA-2179291
(
R-HSA-2173788;
R-HSA-2173789;
R-HSA-5689603
)
R-HSA-2179291
Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1
See in Reactome
R-HSA-2179293
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2179293
Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1
See in Reactome
R-HSA-6781764
(
R-HSA-5689880
)
R-HSA-6781764
Reaction Name: USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1
See in Reactome
|
| MONDO:0007947 |
TGFBR1 |
P36897 |
2.7.11.30
|
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5689603
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
|
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-5688426
R-HSA-392499
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-170835
(
R-HSA-2173789
)
R-HSA-170835
Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
See in Reactome
R-HSA-170843
(
R-HSA-2173789
)
R-HSA-170846
(
R-HSA-2173789
)
R-HSA-170850
(
R-HSA-2173789
)
R-HSA-170850
Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR
See in Reactome
R-HSA-170868
(
R-HSA-2173789
)
R-HSA-170868
Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly
See in Reactome
R-HSA-173483
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173483
Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor
See in Reactome
R-HSA-173512
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173512
Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
See in Reactome
R-HSA-178178
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-178218
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178218
Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1
See in Reactome
R-HSA-2127562
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2127562
Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex
See in Reactome
R-HSA-2128994
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2128994
Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-2169046
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169046
Reaction Name: Degradation of TGF-beta receptor complex
See in Reactome
R-HSA-2169050
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169050
Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
See in Reactome
R-HSA-2179291
(
R-HSA-2173788;
R-HSA-2173789;
R-HSA-5689603
)
R-HSA-2179291
Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1
See in Reactome
R-HSA-2179293
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2179293
Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1
See in Reactome
R-HSA-6781764
(
R-HSA-5689880
)
R-HSA-6781764
Reaction Name: USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1
See in Reactome
|
| MONDO:0007947 |
TGFBR2 |
P37173 |
2.7.11.30
|
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-5689603
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
|
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-5688426
R-HSA-392499
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-170835
(
R-HSA-2173789
)
R-HSA-170835
Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
See in Reactome
R-HSA-170843
(
R-HSA-2173789
)
R-HSA-170846
(
R-HSA-2173789
)
R-HSA-170850
(
R-HSA-2173789
)
R-HSA-170850
Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR
See in Reactome
R-HSA-170861
(
R-HSA-2173789
)
R-HSA-170861
Reaction Name: Dimeric TGF-beta-1 binds to the receptor
See in Reactome
R-HSA-170868
(
R-HSA-2173789
)
R-HSA-170868
Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly
See in Reactome
R-HSA-173483
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173483
Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor
See in Reactome
R-HSA-173512
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173512
Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
See in Reactome
R-HSA-178178
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-178218
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178218
Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1
See in Reactome
R-HSA-2127562
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2127562
Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex
See in Reactome
R-HSA-2128994
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2128994
Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-2169046
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169046
Reaction Name: Degradation of TGF-beta receptor complex
See in Reactome
R-HSA-2169050
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169050
Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
See in Reactome
R-HSA-2179291
(
R-HSA-2173788;
R-HSA-2173789;
R-HSA-5689603
)
R-HSA-2179291
Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1
See in Reactome
R-HSA-2179293
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2179293
Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1
See in Reactome
R-HSA-4332235
(
R-HSA-2173789
)
R-HSA-4332236
(
R-HSA-2173789
)
|
| MONDO:0008170 |
BARD1 |
Q99728 |
2.3.2.27
|
R-HSA-5689901
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-5689603
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-69473
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-69481
R-HSA-212436
R-HSA-74160
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-5693538
R-HSA-392499
R-HSA-69620
R-HSA-73894
R-HSA-5688426
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
R-HSA-73857
|
Gene expression (Transcription)
Metabolism of proteins
DNA Repair
Cell Cycle
|
R-HSA-5659781
(
R-HSA-5693565
)
R-HSA-5659781
Reaction Name: BRCA1 forms a heterodimer with BARD1
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473;
R-HSA-69481
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5689649
(
R-HSA-5689603
)
R-HSA-5691411
(
R-HSA-5689901
)
R-HSA-5691411
Reaction Name: BRCA1-A complex deubiquitinates K63polyUb-histone H2A
See in Reactome
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473;
R-HSA-69481
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473;
R-HSA-69481
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9707051
(
R-HSA-5693565
)
R-HSA-9707051
Reaction Name: UBXN1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
| MONDO:0009693 |
BAP1 |
Q92560 |
3.4.19.12
|
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5689603
|
R-HSA-5688426
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-392499
R-HSA-73894
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
|
Metabolism of proteins
DNA Repair
|
R-HSA-5689630
(
R-HSA-5689603
)
R-HSA-5689630
Reaction Name: BAP1 binds BAP1-interacting complex
See in Reactome
R-HSA-5689649
(
R-HSA-5689603
)
R-HSA-5690759
(
R-HSA-5689603
)
R-HSA-5690759
Reaction Name: BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1
See in Reactome
R-HSA-5690785
(
R-HSA-5689603
)
R-HSA-5690790
(
R-HSA-5689603
)
R-HSA-5690790
Reaction Name: Histone H2A is dubiquitinated by the PR-DUB complex
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
| MONDO:0012212 |
TGFBR1 |
P36897 |
2.7.11.30
|
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5689603
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
|
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-5688426
R-HSA-392499
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-170835
(
R-HSA-2173789
)
R-HSA-170835
Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
See in Reactome
R-HSA-170843
(
R-HSA-2173789
)
R-HSA-170846
(
R-HSA-2173789
)
R-HSA-170850
(
R-HSA-2173789
)
R-HSA-170850
Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR
See in Reactome
R-HSA-170868
(
R-HSA-2173789
)
R-HSA-170868
Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly
See in Reactome
R-HSA-173483
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173483
Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor
See in Reactome
R-HSA-173512
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173512
Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
See in Reactome
R-HSA-178178
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-178218
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178218
Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1
See in Reactome
R-HSA-2127562
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2127562
Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex
See in Reactome
R-HSA-2128994
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2128994
Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-2169046
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169046
Reaction Name: Degradation of TGF-beta receptor complex
See in Reactome
R-HSA-2169050
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169050
Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
See in Reactome
R-HSA-2179291
(
R-HSA-2173788;
R-HSA-2173789;
R-HSA-5689603
)
R-HSA-2179291
Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1
See in Reactome
R-HSA-2179293
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2179293
Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1
See in Reactome
R-HSA-6781764
(
R-HSA-5689880
)
R-HSA-6781764
Reaction Name: USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1
See in Reactome
|
| MONDO:0012212 |
TGFBR2 |
P37173 |
2.7.11.30
|
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-5689603
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
|
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-5688426
R-HSA-392499
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-170835
(
R-HSA-2173789
)
R-HSA-170835
Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
See in Reactome
R-HSA-170843
(
R-HSA-2173789
)
R-HSA-170846
(
R-HSA-2173789
)
R-HSA-170850
(
R-HSA-2173789
)
R-HSA-170850
Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR
See in Reactome
R-HSA-170861
(
R-HSA-2173789
)
R-HSA-170861
Reaction Name: Dimeric TGF-beta-1 binds to the receptor
See in Reactome
R-HSA-170868
(
R-HSA-2173789
)
R-HSA-170868
Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly
See in Reactome
R-HSA-173483
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173483
Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor
See in Reactome
R-HSA-173512
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173512
Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
See in Reactome
R-HSA-178178
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-178218
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178218
Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1
See in Reactome
R-HSA-2127562
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2127562
Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex
See in Reactome
R-HSA-2128994
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2128994
Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-2169046
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169046
Reaction Name: Degradation of TGF-beta receptor complex
See in Reactome
R-HSA-2169050
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169050
Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
See in Reactome
R-HSA-2179291
(
R-HSA-2173788;
R-HSA-2173789;
R-HSA-5689603
)
R-HSA-2179291
Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1
See in Reactome
R-HSA-2179293
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2179293
Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1
See in Reactome
R-HSA-4332235
(
R-HSA-2173789
)
R-HSA-4332236
(
R-HSA-2173789
)
|
| MONDO:0012427 |
TGFBR2 |
P37173 |
2.7.11.30
|
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-5689603
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
|
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-5688426
R-HSA-392499
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-170835
(
R-HSA-2173789
)
R-HSA-170835
Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
See in Reactome
R-HSA-170843
(
R-HSA-2173789
)
R-HSA-170846
(
R-HSA-2173789
)
R-HSA-170850
(
R-HSA-2173789
)
R-HSA-170850
Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR
See in Reactome
R-HSA-170861
(
R-HSA-2173789
)
R-HSA-170861
Reaction Name: Dimeric TGF-beta-1 binds to the receptor
See in Reactome
R-HSA-170868
(
R-HSA-2173789
)
R-HSA-170868
Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly
See in Reactome
R-HSA-173483
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173483
Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor
See in Reactome
R-HSA-173512
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173512
Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
See in Reactome
R-HSA-178178
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-178218
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178218
Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1
See in Reactome
R-HSA-2127562
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2127562
Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex
See in Reactome
R-HSA-2128994
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2128994
Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-2169046
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169046
Reaction Name: Degradation of TGF-beta receptor complex
See in Reactome
R-HSA-2169050
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169050
Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
See in Reactome
R-HSA-2179291
(
R-HSA-2173788;
R-HSA-2173789;
R-HSA-5689603
)
R-HSA-2179291
Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1
See in Reactome
R-HSA-2179293
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2179293
Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1
See in Reactome
R-HSA-4332235
(
R-HSA-2173789
)
R-HSA-4332236
(
R-HSA-2173789
)
|
| MONDO:0013340 |
UCHL1 |
P09936 |
3.4.19.12
|
R-HSA-5689603
|
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5688426
R-HSA-392499
|
Metabolism of proteins
|
R-HSA-5690319
(
R-HSA-5689603
)
R-HSA-5690319
Reaction Name: UCHL1, UCHL3 cleave ubiquitin adducts
See in Reactome
|
| MONDO:0013692 |
BAP1 |
Q92560 |
3.4.19.12
|
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5689603
|
R-HSA-5688426
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-392499
R-HSA-73894
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
|
Metabolism of proteins
DNA Repair
|
R-HSA-5689630
(
R-HSA-5689603
)
R-HSA-5689630
Reaction Name: BAP1 binds BAP1-interacting complex
See in Reactome
R-HSA-5689649
(
R-HSA-5689603
)
R-HSA-5690759
(
R-HSA-5689603
)
R-HSA-5690759
Reaction Name: BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1
See in Reactome
R-HSA-5690785
(
R-HSA-5689603
)
R-HSA-5690790
(
R-HSA-5689603
)
R-HSA-5690790
Reaction Name: Histone H2A is dubiquitinated by the PR-DUB complex
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
| MONDO:0013695 |
TGFBR2 |
P37173 |
2.7.11.30
|
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-5689603
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
|
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-5688426
R-HSA-392499
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-170835
(
R-HSA-2173789
)
R-HSA-170835
Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
See in Reactome
R-HSA-170843
(
R-HSA-2173789
)
R-HSA-170846
(
R-HSA-2173789
)
R-HSA-170850
(
R-HSA-2173789
)
R-HSA-170850
Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR
See in Reactome
R-HSA-170861
(
R-HSA-2173789
)
R-HSA-170861
Reaction Name: Dimeric TGF-beta-1 binds to the receptor
See in Reactome
R-HSA-170868
(
R-HSA-2173789
)
R-HSA-170868
Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly
See in Reactome
R-HSA-173483
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173483
Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor
See in Reactome
R-HSA-173512
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173512
Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
See in Reactome
R-HSA-178178
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-178218
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178218
Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1
See in Reactome
R-HSA-2127562
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2127562
Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex
See in Reactome
R-HSA-2128994
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2128994
Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-2169046
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169046
Reaction Name: Degradation of TGF-beta receptor complex
See in Reactome
R-HSA-2169050
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169050
Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
See in Reactome
R-HSA-2179291
(
R-HSA-2173788;
R-HSA-2173789;
R-HSA-5689603
)
R-HSA-2179291
Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1
See in Reactome
R-HSA-2179293
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2179293
Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1
See in Reactome
R-HSA-4332235
(
R-HSA-2173789
)
R-HSA-4332236
(
R-HSA-2173789
)
|
| MONDO:0014209 |
UCHL1 |
P09936 |
3.4.19.12
|
R-HSA-5689603
|
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5688426
R-HSA-392499
|
Metabolism of proteins
|
R-HSA-5690319
(
R-HSA-5689603
)
R-HSA-5690319
Reaction Name: UCHL1, UCHL3 cleave ubiquitin adducts
See in Reactome
|
| MONDO:0015356 |
BARD1 |
Q99728 |
2.3.2.27
|
R-HSA-5689901
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-5689603
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-69473
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-69481
R-HSA-212436
R-HSA-74160
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-5693538
R-HSA-392499
R-HSA-69620
R-HSA-73894
R-HSA-5688426
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
R-HSA-73857
|
Gene expression (Transcription)
Metabolism of proteins
DNA Repair
Cell Cycle
|
R-HSA-5659781
(
R-HSA-5693565
)
R-HSA-5659781
Reaction Name: BRCA1 forms a heterodimer with BARD1
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473;
R-HSA-69481
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5689649
(
R-HSA-5689603
)
R-HSA-5691411
(
R-HSA-5689901
)
R-HSA-5691411
Reaction Name: BRCA1-A complex deubiquitinates K63polyUb-histone H2A
See in Reactome
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473;
R-HSA-69481
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473;
R-HSA-69481
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9707051
(
R-HSA-5693565
)
R-HSA-9707051
Reaction Name: UBXN1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
| MONDO:0016419 |
BARD1 |
Q99728 |
2.3.2.27
|
R-HSA-5689901
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-5689603
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-69473
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-5633007
R-HSA-69481
R-HSA-212436
R-HSA-74160
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-5693538
R-HSA-392499
R-HSA-69620
R-HSA-73894
R-HSA-5688426
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
R-HSA-73857
|
Gene expression (Transcription)
Metabolism of proteins
DNA Repair
Cell Cycle
|
R-HSA-5659781
(
R-HSA-5693565
)
R-HSA-5659781
Reaction Name: BRCA1 forms a heterodimer with BARD1
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473;
R-HSA-69481
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5689649
(
R-HSA-5689603
)
R-HSA-5691411
(
R-HSA-5689901
)
R-HSA-5691411
Reaction Name: BRCA1-A complex deubiquitinates K63polyUb-histone H2A
See in Reactome
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473;
R-HSA-69481
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473;
R-HSA-69481
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9707051
(
R-HSA-5693565
)
R-HSA-9707051
Reaction Name: UBXN1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
| MONDO:0016642 |
BAP1 |
Q92560 |
3.4.19.12
|
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5689603
|
R-HSA-5688426
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-392499
R-HSA-73894
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
|
Metabolism of proteins
DNA Repair
|
R-HSA-5689630
(
R-HSA-5689603
)
R-HSA-5689630
Reaction Name: BAP1 binds BAP1-interacting complex
See in Reactome
R-HSA-5689649
(
R-HSA-5689603
)
R-HSA-5690759
(
R-HSA-5689603
)
R-HSA-5690759
Reaction Name: BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1
See in Reactome
R-HSA-5690785
(
R-HSA-5689603
)
R-HSA-5690790
(
R-HSA-5689603
)
R-HSA-5690790
Reaction Name: Histone H2A is dubiquitinated by the PR-DUB complex
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
| MONDO:0019438 |
BAP1 |
Q92560 |
3.4.19.12
|
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-5689603
|
R-HSA-5688426
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-392499
R-HSA-73894
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
|
Metabolism of proteins
DNA Repair
|
R-HSA-5689630
(
R-HSA-5689603
)
R-HSA-5689630
Reaction Name: BAP1 binds BAP1-interacting complex
See in Reactome
R-HSA-5689649
(
R-HSA-5689603
)
R-HSA-5690759
(
R-HSA-5689603
)
R-HSA-5690759
Reaction Name: BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1
See in Reactome
R-HSA-5690785
(
R-HSA-5689603
)
R-HSA-5690790
(
R-HSA-5689603
)
R-HSA-5690790
Reaction Name: Histone H2A is dubiquitinated by the PR-DUB complex
See in Reactome
R-HSA-9700998
(
R-HSA-5693565
)
R-HSA-9700998
Reaction Name: BAP1 disrupts the BRCA1:BARD1 heterodimer
See in Reactome
R-HSA-9701000
(
R-HSA-5693565
)
R-HSA-9701000
Reaction Name: BRCA1:BARD1 heterodimer autoubiquitinates
See in Reactome
R-HSA-9701003
(
R-HSA-5693565
)
R-HSA-9701003
Reaction Name: BAP1 binds BRCA1:BARD1 heterodimer
See in Reactome
|
| MONDO:0019625 |
TGFBR1 |
P36897 |
2.7.11.30
|
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5689603
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
|
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-5688426
R-HSA-392499
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-170835
(
R-HSA-2173789
)
R-HSA-170835
Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
See in Reactome
R-HSA-170843
(
R-HSA-2173789
)
R-HSA-170846
(
R-HSA-2173789
)
R-HSA-170850
(
R-HSA-2173789
)
R-HSA-170850
Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR
See in Reactome
R-HSA-170868
(
R-HSA-2173789
)
R-HSA-170868
Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly
See in Reactome
R-HSA-173483
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173483
Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor
See in Reactome
R-HSA-173512
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173512
Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
See in Reactome
R-HSA-178178
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-178218
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178218
Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1
See in Reactome
R-HSA-2127562
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2127562
Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex
See in Reactome
R-HSA-2128994
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2128994
Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-2169046
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169046
Reaction Name: Degradation of TGF-beta receptor complex
See in Reactome
R-HSA-2169050
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169050
Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
See in Reactome
R-HSA-2179291
(
R-HSA-2173788;
R-HSA-2173789;
R-HSA-5689603
)
R-HSA-2179291
Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1
See in Reactome
R-HSA-2179293
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2179293
Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1
See in Reactome
R-HSA-6781764
(
R-HSA-5689880
)
R-HSA-6781764
Reaction Name: USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1
See in Reactome
|
| MONDO:0019625 |
TGFBR2 |
P37173 |
2.7.11.30
|
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-5689603
R-HSA-2173789
R-HSA-2173789
Reactome Name: TGF-beta receptor signaling activates SMADs
See in Reactome
R-HSA-2173788
R-HSA-2173788
Reactome Name: Downregulation of TGF-beta receptor signaling
See in Reactome
|
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-5688426
R-HSA-392499
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-170835
(
R-HSA-2173789
)
R-HSA-170835
Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
See in Reactome
R-HSA-170843
(
R-HSA-2173789
)
R-HSA-170846
(
R-HSA-2173789
)
R-HSA-170850
(
R-HSA-2173789
)
R-HSA-170850
Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR
See in Reactome
R-HSA-170861
(
R-HSA-2173789
)
R-HSA-170861
Reaction Name: Dimeric TGF-beta-1 binds to the receptor
See in Reactome
R-HSA-170868
(
R-HSA-2173789
)
R-HSA-170868
Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly
See in Reactome
R-HSA-173483
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173483
Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor
See in Reactome
R-HSA-173512
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-173512
Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
See in Reactome
R-HSA-178178
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178189
Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
See in Reactome
R-HSA-178218
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-178218
Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1
See in Reactome
R-HSA-2127562
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2127562
Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex
See in Reactome
R-HSA-2128994
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2128994
Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-2169046
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169046
Reaction Name: Degradation of TGF-beta receptor complex
See in Reactome
R-HSA-2169050
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2169050
Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7
See in Reactome
R-HSA-2179291
(
R-HSA-2173788;
R-HSA-2173789;
R-HSA-5689603
)
R-HSA-2179291
Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1
See in Reactome
R-HSA-2179293
(
R-HSA-2173788;
R-HSA-2173789
)
R-HSA-2179293
Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1
See in Reactome
R-HSA-4332235
(
R-HSA-2173789
)
R-HSA-4332236
(
R-HSA-2173789
)
|
| MONDO:0030907 |
OGT |
O15294 |
2.4.1.255
|
R-HSA-3214847
R-HSA-5213460
R-HSA-5213460
Reactome Name: RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-5689603
R-HSA-5675482
R-HSA-5675482
Reactome Name: Regulation of necroptotic cell death
See in Reactome
|
R-HSA-5688426
R-HSA-392499
R-HSA-5218859
R-HSA-5357801
R-HSA-4839726
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-3247509
|
Metabolism of proteins
Programmed Cell Death
Chromatin organization
|
R-HSA-3321805
(
R-HSA-3214847
)
R-HSA-5213462
(
R-HSA-5213460
)
R-HSA-5689630
(
R-HSA-5689603
)
R-HSA-5689630
Reaction Name: BAP1 binds BAP1-interacting complex
See in Reactome
R-HSA-9687828
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9687828
Reaction Name: O-GlcNAcylation of RIPK3 (TLR4 signaling)
See in Reactome
|
| MONDO:0030924 |
PSMB10 |
P40306 |
3.4.25.1
|
R-HSA-8951664
R-HSA-4608870
R-HSA-4608870
Reactome Name: Asymmetric localization of PCP proteins
See in Reactome
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-8852276
R-HSA-8852276
Reactome Name: The role of GTSE1 in G2/M progression after G2 checkpoint
See in Reactome
R-HSA-8941858
R-HSA-8941858
Reactome Name: Regulation of RUNX3 expression and activity
See in Reactome
R-HSA-174184
R-HSA-174184
Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A
See in Reactome
R-HSA-69017
R-HSA-69017
Reactome Name: CDK-mediated phosphorylation and removal of Cdc6
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-187577
R-HSA-187577
Reactome Name: SCF(Skp2)-mediated degradation of p27/p21
See in Reactome
R-HSA-1236978
R-HSA-1236978
Reactome Name: Cross-presentation of soluble exogenous antigens (endosomes)
See in Reactome
R-HSA-5610780
R-HSA-5610780
Reactome Name: Degradation of GLI1 by the proteasome
See in Reactome
R-HSA-5610785
R-HSA-5610785
Reactome Name: GLI3 is processed to GLI3R by the proteasome
See in Reactome
R-HSA-8854050
R-HSA-8854050
Reactome Name: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
See in Reactome
R-HSA-69601
R-HSA-69601
Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
See in Reactome
R-HSA-1236974
R-HSA-5610783
R-HSA-5610783
Reactome Name: Degradation of GLI2 by the proteasome
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5668541
R-HSA-5668541
Reactome Name: TNFR2 non-canonical NF-kB pathway
See in Reactome
R-HSA-1169091
R-HSA-1169091
Reactome Name: Activation of NF-kappaB in B cells
See in Reactome
R-HSA-4641258
R-HSA-9010553
R-HSA-9010553
Reactome Name: Regulation of expression of SLITs and ROBOs
See in Reactome
R-HSA-202424
R-HSA-450408
R-HSA-450408
Reactome Name: AUF1 (hnRNP D0) binds and destabilizes mRNA
See in Reactome
R-HSA-5687128
R-HSA-5676590
R-HSA-5676590
Reactome Name: NIK-->noncanonical NF-kB signaling
See in Reactome
R-HSA-1234176
R-HSA-1234176
Reactome Name: Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
See in Reactome
R-HSA-211733
R-HSA-211733
Reactome Name: Regulation of activated PAK-2p34 by proteasome mediated degradation
See in Reactome
R-HSA-4641257
R-HSA-5607761
R-HSA-5607761
Reactome Name: Dectin-1 mediated noncanonical NF-kB signaling
See in Reactome
R-HSA-5358346
R-HSA-5607764
R-HSA-8939236
R-HSA-8939236
Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs
See in Reactome
R-HSA-174178
R-HSA-174178
Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
See in Reactome
R-HSA-8939902
R-HSA-8939902
Reactome Name: Regulation of RUNX2 expression and activity
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-68949
R-HSA-69481
R-HSA-5658442
R-HSA-174154
R-HSA-174154
Reactome Name: APC/C:Cdc20 mediated degradation of Securin
See in Reactome
R-HSA-195253
R-HSA-195253
Reactome Name: Degradation of beta-catenin by the destruction complex
See in Reactome
R-HSA-174084
R-HSA-174084
Reactome Name: Autodegradation of Cdh1 by Cdh1:APC/C
See in Reactome
R-HSA-174113
R-HSA-174113
Reactome Name: SCF-beta-TrCP mediated degradation of Emi1
See in Reactome
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
R-HSA-350562
R-HSA-350562
Reactome Name: Regulation of ornithine decarboxylase (ODC)
See in Reactome
R-HSA-5632684
R-HSA-5689603
R-HSA-75815
R-HSA-75815
Reactome Name: Ubiquitin-dependent degradation of Cyclin D
See in Reactome
R-HSA-9020702
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-376176
R-HSA-449147
R-HSA-8953897
R-HSA-5688426
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-9013694
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-5358351
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5684996
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-174143
R-HSA-174143
Reactome Name: APC/C-mediated degradation of cell cycle proteins
See in Reactome
R-HSA-69052
R-HSA-69052
Reactome Name: Switching of origins to a post-replicative state
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-4086400
R-HSA-212436
R-HSA-74160
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-1234174
R-HSA-69278
R-HSA-69541
R-HSA-382551
R-HSA-179419
R-HSA-179419
Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
See in Reactome
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-5673001
R-HSA-202403
R-HSA-69239
R-HSA-446652
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-176408
R-HSA-176408
Reactome Name: Regulation of APC/C activators between G1/S and early anaphase
See in Reactome
R-HSA-176409
R-HSA-176409
Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-169911
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-9675108
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-8953854
R-HSA-168249
R-HSA-453274
R-HSA-392499
R-HSA-453276
R-HSA-453276
Reactome Name: Regulation of mitotic cell cycle
See in Reactome
R-HSA-68886
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-176814
R-HSA-176814
Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-5610787
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-157118
R-HSA-351202
R-HSA-69275
R-HSA-195721
R-HSA-69242
R-HSA-1257604
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-109581
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-69615
R-HSA-69306
R-HSA-69610
R-HSA-69610
Reactome Name: p53-Independent DNA Damage Response
See in Reactome
R-HSA-69613
R-HSA-69613
Reactome Name: p53-Independent G1/S DNA damage checkpoint
See in Reactome
R-HSA-71291
R-HSA-71291
Reactome Name: Metabolism of amino acids and derivatives
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-422475
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-162582
R-HSA-68882
|
Cellular responses to stimuli
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Transport of small molecules
Metabolism of RNA
Metabolism of proteins
DNA Replication
Signal Transduction
|
R-HSA-1168640
(
R-HSA-1169091
)
R-HSA-1234159
(
R-HSA-1234176
)
R-HSA-1234159
Reaction Name: Proteasome proteolyzes ub-HIF-alpha
See in Reactome
R-HSA-1236935
(
R-HSA-1236974
)
R-HSA-1236935
Reaction Name: Proteasomal cleavage of substrate
See in Reactome
R-HSA-1236970
(
R-HSA-1236978
)
R-HSA-1236970
Reaction Name: Proteasomal clevage of exogenous antigen
See in Reactome
R-HSA-1504193
(
R-HSA-4641258
)
R-HSA-1504193
Reaction Name: Ubiquitinated DVL is degraded by the proteasome
See in Reactome
R-HSA-174058
(
R-HSA-174084
)
R-HSA-174058
Reaction Name: Degradation of multiubiquitinated Cdh1
See in Reactome
R-HSA-174105
(
R-HSA-174178
)
R-HSA-174105
Reaction Name: Degradation of multiubiquitinated cell cycle proteins
See in Reactome
R-HSA-174202
(
R-HSA-174154;
R-HSA-2467813
)
R-HSA-174202
Reaction Name: Degradation of multiubiquitinated Securin
See in Reactome
R-HSA-174203
(
R-HSA-174113
)
R-HSA-174203
Reaction Name: SCF-mediated degradation of Emi1
See in Reactome
R-HSA-174255
(
R-HSA-174184
)
R-HSA-174255
Reaction Name: Degradation multiubiquitinated Cyclin A
See in Reactome
R-HSA-187574
(
R-HSA-187577
)
R-HSA-187574
Reaction Name: Degradation of ubiquitinated p27/p21 by the 26S proteasome
See in Reactome
R-HSA-188191
(
R-HSA-174178
)
R-HSA-188191
Reaction Name: APC/C:Cdh1-mediated degradation of Skp2
See in Reactome
R-HSA-209061
(
R-HSA-9020702
)
R-HSA-209061
Reaction Name: Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex
See in Reactome
R-HSA-211715
(
R-HSA-211733
)
R-HSA-211715
Reaction Name: Proteasome mediated degradation of PAK-2p34
See in Reactome
R-HSA-2130282
(
R-HSA-195253
)
R-HSA-2130282
Reaction Name: Degradation of ubiquitinated beta catenin by the proteasome
See in Reactome
R-HSA-264458
(
R-HSA-349425
)
R-HSA-264458
Reaction Name: Proteasome mediated degradation of COP1
See in Reactome
R-HSA-353125
(
R-HSA-350562
)
R-HSA-353125
Reaction Name: 26S proteosome degrades ODC holoenzyme complex
See in Reactome
R-HSA-3640874
(
R-HSA-4641257
)
R-HSA-3640874
Reaction Name: Ub-RibC-AXIN is degraded by the proteasome
See in Reactome
R-HSA-450466
(
R-HSA-450408
)
R-HSA-4608855
(
R-HSA-4608870
)
R-HSA-4608855
Reaction Name: PRICKLE1 is degraded by the proteasome
See in Reactome
R-HSA-4641256
(
R-HSA-4641257
)
R-HSA-4641256
Reaction Name: Ubiquitinated AXIN is degraded by the proteasome
See in Reactome
R-HSA-4641260
(
R-HSA-4641258
)
R-HSA-4641260
Reaction Name: Ubiquitinated DVL1 is degraded by the proteasome
See in Reactome
R-HSA-5362448
(
R-HSA-5358346
)
R-HSA-5362448
Reaction Name: Hh C-terminal fragments are degraded by the proteasome
See in Reactome
R-HSA-5607724
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-5607724
Reaction Name: 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex
See in Reactome
R-HSA-5607731
(
R-HSA-5607761;
R-HSA-5607764;
R-HSA-5668541;
R-HSA-5676590
)
R-HSA-5607731
Reaction Name: 26S proteasome processes p-7S-p100:RELB to form p52:RELB
See in Reactome
R-HSA-5610754
(
R-HSA-5610785
)
R-HSA-5610754
Reaction Name: GLI3 is partially degraded by the proteasome to yield the GLI3 repressor
See in Reactome
R-HSA-5610757
(
R-HSA-5610783
)
R-HSA-5610757
Reaction Name: GLI2 is degraded by the proteasome
See in Reactome
R-HSA-5610758
(
R-HSA-5610780
)
R-HSA-5610758
Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP
See in Reactome
R-HSA-5610760
(
R-HSA-5610780
)
R-HSA-5610760
Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by ITCH
See in Reactome
R-HSA-5635854
(
R-HSA-5632684
)
R-HSA-5635854
Reaction Name: GLI2,3 are degraded by the proteasome
See in Reactome
R-HSA-5635868
(
R-HSA-5632684
)
R-HSA-5635868
Reaction Name: ub-GLI is degraded by the proteasome
See in Reactome
R-HSA-5658430
(
R-HSA-5658442
)
R-HSA-5658430
Reaction Name: NF1 is degraded by the proteasome
See in Reactome
R-HSA-5665854
(
R-HSA-5689603
)
R-HSA-5665854
Reaction Name: ADRM1:26S proteaseome binds UCHL5
See in Reactome
R-HSA-5665871
(
R-HSA-5689603
)
R-HSA-5668481
(
R-HSA-5668541
)
R-HSA-5668481
Reaction Name: Protesomal degradation of K48polyUb-TRAF3
See in Reactome
R-HSA-5668520
(
R-HSA-5668541
)
R-HSA-5668520
Reaction Name: 26Sproteasome degrades K48polyUb-NIK
See in Reactome
R-HSA-5687112
(
R-HSA-5687128
)
R-HSA-5687112
Reaction Name: MAPK6 is degraded by the 26S proteasome
See in Reactome
R-HSA-5689539
(
R-HSA-5689880
)
R-HSA-5689539
Reaction Name: ADRM1:26S proteaseome binds USP14
See in Reactome
R-HSA-68825
()
R-HSA-68825
Reaction Name: Ubiquitinated geminin is degraded by the proteasome
See in Reactome
R-HSA-68948
(
R-HSA-68949
)
R-HSA-68948
Reaction Name: Ubiquitinated Orc1 is degraded by the proteasome
See in Reactome
R-HSA-69016
(
R-HSA-69017
)
R-HSA-69016
Reaction Name: Ubiquitinated Cdc6 is degraded by the proteasome
See in Reactome
R-HSA-69600
(
R-HSA-69601
)
R-HSA-69600
Reaction Name: Proteolytic degradation of ubiquitinated-Cdc25A
See in Reactome
R-HSA-75825
(
R-HSA-75815
)
R-HSA-75825
Reaction Name: Proteasome mediated degradation of Cyclin D1
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8852354
(
R-HSA-69481;
R-HSA-8852276
)
R-HSA-8852354
Reaction Name: GTSE1 facilitates proteasome-mediated degradation of TP53
See in Reactome
R-HSA-8854044
(
R-HSA-8854050
)
R-HSA-8854044
Reaction Name: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
See in Reactome
R-HSA-8854071
(
R-HSA-8854050
)
R-HSA-8854071
Reaction Name: Proteasome-mediated degradation of PolyUb-FBXL7
See in Reactome
R-HSA-8866553
(
R-HSA-382556
)
R-HSA-8866553
Reaction Name: misfolded CFTR is degraded by the 26S proteasome
See in Reactome
R-HSA-8932355
(
R-HSA-8951664
)
R-HSA-8932355
Reaction Name: 26S proteasome degrades Ub-NFE2L2
See in Reactome
R-HSA-8939801
(
R-HSA-8939902
)
R-HSA-8939801
Reaction Name: 26S proteasome degrades PolyUb-RUNX2
See in Reactome
R-HSA-8952408
(
R-HSA-8941858
)
R-HSA-8952408
Reaction Name: Polyubiquitinated RUNX3 is degraded by the proteasome
See in Reactome
R-HSA-8956140
(
R-HSA-8951664
)
R-HSA-8956140
Reaction Name: NEDD8 and UBD bind NUB1 and the 26S proteasome
See in Reactome
R-HSA-8956184
(
R-HSA-8951664
)
R-HSA-8956184
Reaction Name: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
See in Reactome
R-HSA-8957265
(
R-HSA-8939236
)
R-HSA-8957265
Reaction Name: 26S proteasome degrades TP73 polyubiquitinated by ITCH
See in Reactome
R-HSA-9008110
(
R-HSA-8939902
)
R-HSA-9008110
Reaction Name: Proteasome degrades polyubiquitinated RUNX2
See in Reactome
R-HSA-9008475
(
R-HSA-8939902
)
R-HSA-9008475
Reaction Name: Proteasome degrades polyubiquitinated RUNX2
See in Reactome
R-HSA-9009362
(
R-HSA-8939902
)
R-HSA-9009362
Reaction Name: Proteasome degrades PolyUb-RUNX2
See in Reactome
R-HSA-9011313
(
R-HSA-9010553
)
R-HSA-9011313
Reaction Name: Proteasome degrades ubiquitinated ROBO3.1
See in Reactome
R-HSA-9604642
(
R-HSA-9604323
)
R-HSA-9604642
Reaction Name: Proteasome degrades ubiquitinated NICD4
See in Reactome
R-HSA-9755303
(
R-HSA-8951664
)
R-HSA-9755303
Reaction Name: 26S proteasome degrades HIFalpha
See in Reactome
R-HSA-9755306
(
R-HSA-8951664
)
R-HSA-9755306
Reaction Name: ub UBXN7 is degraded by the 26S proteasome
See in Reactome
R-HSA-9762096
()
R-HSA-9762096
Reaction Name: Ub,pS335,S338,T NFE2L2 is degraded
See in Reactome
R-HSA-983150
(
R-HSA-983168
)
R-HSA-983150
Reaction Name: Proteasomal cleavage of substrate
See in Reactome
|
| MONDO:0054698 |
PSMB8 |
P28062 |
3.4.25.1
|
R-HSA-8951664
R-HSA-4608870
R-HSA-4608870
Reactome Name: Asymmetric localization of PCP proteins
See in Reactome
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-8852276
R-HSA-8852276
Reactome Name: The role of GTSE1 in G2/M progression after G2 checkpoint
See in Reactome
R-HSA-8941858
R-HSA-8941858
Reactome Name: Regulation of RUNX3 expression and activity
See in Reactome
R-HSA-174184
R-HSA-174184
Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A
See in Reactome
R-HSA-69017
R-HSA-69017
Reactome Name: CDK-mediated phosphorylation and removal of Cdc6
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-187577
R-HSA-187577
Reactome Name: SCF(Skp2)-mediated degradation of p27/p21
See in Reactome
R-HSA-1236978
R-HSA-1236978
Reactome Name: Cross-presentation of soluble exogenous antigens (endosomes)
See in Reactome
R-HSA-5610780
R-HSA-5610780
Reactome Name: Degradation of GLI1 by the proteasome
See in Reactome
R-HSA-5610785
R-HSA-5610785
Reactome Name: GLI3 is processed to GLI3R by the proteasome
See in Reactome
R-HSA-8854050
R-HSA-8854050
Reactome Name: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
See in Reactome
R-HSA-69601
R-HSA-69601
Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
See in Reactome
R-HSA-1236974
R-HSA-5610783
R-HSA-5610783
Reactome Name: Degradation of GLI2 by the proteasome
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5668541
R-HSA-5668541
Reactome Name: TNFR2 non-canonical NF-kB pathway
See in Reactome
R-HSA-1169091
R-HSA-1169091
Reactome Name: Activation of NF-kappaB in B cells
See in Reactome
R-HSA-4641258
R-HSA-9010553
R-HSA-9010553
Reactome Name: Regulation of expression of SLITs and ROBOs
See in Reactome
R-HSA-202424
R-HSA-450408
R-HSA-450408
Reactome Name: AUF1 (hnRNP D0) binds and destabilizes mRNA
See in Reactome
R-HSA-5687128
R-HSA-909733
R-HSA-909733
Reactome Name: Interferon alpha/beta signaling
See in Reactome
R-HSA-5676590
R-HSA-5676590
Reactome Name: NIK-->noncanonical NF-kB signaling
See in Reactome
R-HSA-1234176
R-HSA-1234176
Reactome Name: Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
See in Reactome
R-HSA-211733
R-HSA-211733
Reactome Name: Regulation of activated PAK-2p34 by proteasome mediated degradation
See in Reactome
R-HSA-4641257
R-HSA-5607761
R-HSA-5607761
Reactome Name: Dectin-1 mediated noncanonical NF-kB signaling
See in Reactome
R-HSA-5358346
R-HSA-5607764
R-HSA-8939236
R-HSA-8939236
Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs
See in Reactome
R-HSA-174178
R-HSA-174178
Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
See in Reactome
R-HSA-8939902
R-HSA-8939902
Reactome Name: Regulation of RUNX2 expression and activity
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-68949
R-HSA-69481
R-HSA-5658442
R-HSA-174154
R-HSA-174154
Reactome Name: APC/C:Cdc20 mediated degradation of Securin
See in Reactome
R-HSA-195253
R-HSA-195253
Reactome Name: Degradation of beta-catenin by the destruction complex
See in Reactome
R-HSA-174084
R-HSA-174084
Reactome Name: Autodegradation of Cdh1 by Cdh1:APC/C
See in Reactome
R-HSA-174113
R-HSA-174113
Reactome Name: SCF-beta-TrCP mediated degradation of Emi1
See in Reactome
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
R-HSA-350562
R-HSA-350562
Reactome Name: Regulation of ornithine decarboxylase (ODC)
See in Reactome
R-HSA-5632684
R-HSA-5689603
R-HSA-75815
R-HSA-75815
Reactome Name: Ubiquitin-dependent degradation of Cyclin D
See in Reactome
R-HSA-9020702
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-376176
R-HSA-449147
R-HSA-8953897
R-HSA-5688426
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-9013694
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-5358351
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5684996
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-174143
R-HSA-174143
Reactome Name: APC/C-mediated degradation of cell cycle proteins
See in Reactome
R-HSA-69052
R-HSA-69052
Reactome Name: Switching of origins to a post-replicative state
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-4086400
R-HSA-212436
R-HSA-74160
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-1234174
R-HSA-69278
R-HSA-69541
R-HSA-382551
R-HSA-179419
R-HSA-179419
Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
See in Reactome
R-HSA-913531
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-5673001
R-HSA-202403
R-HSA-69239
R-HSA-446652
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-176408
R-HSA-176408
Reactome Name: Regulation of APC/C activators between G1/S and early anaphase
See in Reactome
R-HSA-176409
R-HSA-176409
Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-169911
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-9675108
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-8953854
R-HSA-168249
R-HSA-453274
R-HSA-392499
R-HSA-453276
R-HSA-453276
Reactome Name: Regulation of mitotic cell cycle
See in Reactome
R-HSA-68886
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-176814
R-HSA-176814
Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-5610787
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-157118
R-HSA-351202
R-HSA-69275
R-HSA-195721
R-HSA-69242
R-HSA-1257604
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-109581
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-69615
R-HSA-69306
R-HSA-69610
R-HSA-69610
Reactome Name: p53-Independent DNA Damage Response
See in Reactome
R-HSA-69613
R-HSA-69613
Reactome Name: p53-Independent G1/S DNA damage checkpoint
See in Reactome
R-HSA-71291
R-HSA-71291
Reactome Name: Metabolism of amino acids and derivatives
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-422475
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-162582
R-HSA-68882
|
Cellular responses to stimuli
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Transport of small molecules
Metabolism of RNA
Metabolism of proteins
DNA Replication
Signal Transduction
|
R-HSA-1015702
(
R-HSA-909733
)
R-HSA-1015702
Reaction Name: Expression of IFN-induced genes
See in Reactome
R-HSA-1168640
(
R-HSA-1169091
)
R-HSA-1234159
(
R-HSA-1234176
)
R-HSA-1234159
Reaction Name: Proteasome proteolyzes ub-HIF-alpha
See in Reactome
R-HSA-1236935
(
R-HSA-1236974
)
R-HSA-1236935
Reaction Name: Proteasomal cleavage of substrate
See in Reactome
R-HSA-1236970
(
R-HSA-1236978
)
R-HSA-1236970
Reaction Name: Proteasomal clevage of exogenous antigen
See in Reactome
R-HSA-1504193
(
R-HSA-4641258
)
R-HSA-1504193
Reaction Name: Ubiquitinated DVL is degraded by the proteasome
See in Reactome
R-HSA-174058
(
R-HSA-174084
)
R-HSA-174058
Reaction Name: Degradation of multiubiquitinated Cdh1
See in Reactome
R-HSA-174105
(
R-HSA-174178
)
R-HSA-174105
Reaction Name: Degradation of multiubiquitinated cell cycle proteins
See in Reactome
R-HSA-174202
(
R-HSA-174154;
R-HSA-2467813
)
R-HSA-174202
Reaction Name: Degradation of multiubiquitinated Securin
See in Reactome
R-HSA-174203
(
R-HSA-174113
)
R-HSA-174203
Reaction Name: SCF-mediated degradation of Emi1
See in Reactome
R-HSA-174255
(
R-HSA-174184
)
R-HSA-174255
Reaction Name: Degradation multiubiquitinated Cyclin A
See in Reactome
R-HSA-187574
(
R-HSA-187577
)
R-HSA-187574
Reaction Name: Degradation of ubiquitinated p27/p21 by the 26S proteasome
See in Reactome
R-HSA-188191
(
R-HSA-174178
)
R-HSA-188191
Reaction Name: APC/C:Cdh1-mediated degradation of Skp2
See in Reactome
R-HSA-209061
(
R-HSA-9020702
)
R-HSA-209061
Reaction Name: Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex
See in Reactome
R-HSA-211715
(
R-HSA-211733
)
R-HSA-211715
Reaction Name: Proteasome mediated degradation of PAK-2p34
See in Reactome
R-HSA-2130282
(
R-HSA-195253
)
R-HSA-2130282
Reaction Name: Degradation of ubiquitinated beta catenin by the proteasome
See in Reactome
R-HSA-264458
(
R-HSA-349425
)
R-HSA-264458
Reaction Name: Proteasome mediated degradation of COP1
See in Reactome
R-HSA-353125
(
R-HSA-350562
)
R-HSA-353125
Reaction Name: 26S proteosome degrades ODC holoenzyme complex
See in Reactome
R-HSA-3640874
(
R-HSA-4641257
)
R-HSA-3640874
Reaction Name: Ub-RibC-AXIN is degraded by the proteasome
See in Reactome
R-HSA-450466
(
R-HSA-450408
)
R-HSA-4608855
(
R-HSA-4608870
)
R-HSA-4608855
Reaction Name: PRICKLE1 is degraded by the proteasome
See in Reactome
R-HSA-4641256
(
R-HSA-4641257
)
R-HSA-4641256
Reaction Name: Ubiquitinated AXIN is degraded by the proteasome
See in Reactome
R-HSA-4641260
(
R-HSA-4641258
)
R-HSA-4641260
Reaction Name: Ubiquitinated DVL1 is degraded by the proteasome
See in Reactome
R-HSA-5362448
(
R-HSA-5358346
)
R-HSA-5362448
Reaction Name: Hh C-terminal fragments are degraded by the proteasome
See in Reactome
R-HSA-5607724
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-5607724
Reaction Name: 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex
See in Reactome
R-HSA-5607731
(
R-HSA-5607761;
R-HSA-5607764;
R-HSA-5668541;
R-HSA-5676590
)
R-HSA-5607731
Reaction Name: 26S proteasome processes p-7S-p100:RELB to form p52:RELB
See in Reactome
R-HSA-5610754
(
R-HSA-5610785
)
R-HSA-5610754
Reaction Name: GLI3 is partially degraded by the proteasome to yield the GLI3 repressor
See in Reactome
R-HSA-5610757
(
R-HSA-5610783
)
R-HSA-5610757
Reaction Name: GLI2 is degraded by the proteasome
See in Reactome
R-HSA-5610758
(
R-HSA-5610780
)
R-HSA-5610758
Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP
See in Reactome
R-HSA-5610760
(
R-HSA-5610780
)
R-HSA-5610760
Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by ITCH
See in Reactome
R-HSA-5635854
(
R-HSA-5632684
)
R-HSA-5635854
Reaction Name: GLI2,3 are degraded by the proteasome
See in Reactome
R-HSA-5635868
(
R-HSA-5632684
)
R-HSA-5635868
Reaction Name: ub-GLI is degraded by the proteasome
See in Reactome
R-HSA-5658430
(
R-HSA-5658442
)
R-HSA-5658430
Reaction Name: NF1 is degraded by the proteasome
See in Reactome
R-HSA-5665854
(
R-HSA-5689603
)
R-HSA-5665854
Reaction Name: ADRM1:26S proteaseome binds UCHL5
See in Reactome
R-HSA-5665871
(
R-HSA-5689603
)
R-HSA-5668481
(
R-HSA-5668541
)
R-HSA-5668481
Reaction Name: Protesomal degradation of K48polyUb-TRAF3
See in Reactome
R-HSA-5668520
(
R-HSA-5668541
)
R-HSA-5668520
Reaction Name: 26Sproteasome degrades K48polyUb-NIK
See in Reactome
R-HSA-5687112
(
R-HSA-5687128
)
R-HSA-5687112
Reaction Name: MAPK6 is degraded by the 26S proteasome
See in Reactome
R-HSA-5689539
(
R-HSA-5689880
)
R-HSA-5689539
Reaction Name: ADRM1:26S proteaseome binds USP14
See in Reactome
R-HSA-68825
()
R-HSA-68825
Reaction Name: Ubiquitinated geminin is degraded by the proteasome
See in Reactome
R-HSA-68948
(
R-HSA-68949
)
R-HSA-68948
Reaction Name: Ubiquitinated Orc1 is degraded by the proteasome
See in Reactome
R-HSA-69016
(
R-HSA-69017
)
R-HSA-69016
Reaction Name: Ubiquitinated Cdc6 is degraded by the proteasome
See in Reactome
R-HSA-69600
(
R-HSA-69601
)
R-HSA-69600
Reaction Name: Proteolytic degradation of ubiquitinated-Cdc25A
See in Reactome
R-HSA-75825
(
R-HSA-75815
)
R-HSA-75825
Reaction Name: Proteasome mediated degradation of Cyclin D1
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8852354
(
R-HSA-69481;
R-HSA-8852276
)
R-HSA-8852354
Reaction Name: GTSE1 facilitates proteasome-mediated degradation of TP53
See in Reactome
R-HSA-8854044
(
R-HSA-8854050
)
R-HSA-8854044
Reaction Name: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
See in Reactome
R-HSA-8854071
(
R-HSA-8854050
)
R-HSA-8854071
Reaction Name: Proteasome-mediated degradation of PolyUb-FBXL7
See in Reactome
R-HSA-8866553
(
R-HSA-382556
)
R-HSA-8866553
Reaction Name: misfolded CFTR is degraded by the 26S proteasome
See in Reactome
R-HSA-8932355
(
R-HSA-8951664
)
R-HSA-8932355
Reaction Name: 26S proteasome degrades Ub-NFE2L2
See in Reactome
R-HSA-8939801
(
R-HSA-8939902
)
R-HSA-8939801
Reaction Name: 26S proteasome degrades PolyUb-RUNX2
See in Reactome
R-HSA-8952408
(
R-HSA-8941858
)
R-HSA-8952408
Reaction Name: Polyubiquitinated RUNX3 is degraded by the proteasome
See in Reactome
R-HSA-8956140
(
R-HSA-8951664
)
R-HSA-8956140
Reaction Name: NEDD8 and UBD bind NUB1 and the 26S proteasome
See in Reactome
R-HSA-8956184
(
R-HSA-8951664
)
R-HSA-8956184
Reaction Name: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
See in Reactome
R-HSA-8957265
(
R-HSA-8939236
)
R-HSA-8957265
Reaction Name: 26S proteasome degrades TP73 polyubiquitinated by ITCH
See in Reactome
R-HSA-9008110
(
R-HSA-8939902
)
R-HSA-9008110
Reaction Name: Proteasome degrades polyubiquitinated RUNX2
See in Reactome
R-HSA-9008475
(
R-HSA-8939902
)
R-HSA-9008475
Reaction Name: Proteasome degrades polyubiquitinated RUNX2
See in Reactome
R-HSA-9009362
(
R-HSA-8939902
)
R-HSA-9009362
Reaction Name: Proteasome degrades PolyUb-RUNX2
See in Reactome
R-HSA-9011313
(
R-HSA-9010553
)
R-HSA-9011313
Reaction Name: Proteasome degrades ubiquitinated ROBO3.1
See in Reactome
R-HSA-9604642
(
R-HSA-9604323
)
R-HSA-9604642
Reaction Name: Proteasome degrades ubiquitinated NICD4
See in Reactome
R-HSA-9755303
(
R-HSA-8951664
)
R-HSA-9755303
Reaction Name: 26S proteasome degrades HIFalpha
See in Reactome
R-HSA-9755306
(
R-HSA-8951664
)
R-HSA-9755306
Reaction Name: ub UBXN7 is degraded by the 26S proteasome
See in Reactome
R-HSA-9762096
()
R-HSA-9762096
Reaction Name: Ub,pS335,S338,T NFE2L2 is degraded
See in Reactome
R-HSA-983150
(
R-HSA-983168
)
R-HSA-983150
Reaction Name: Proteasomal cleavage of substrate
See in Reactome
|
| MONDO:0054699 |
PSMB9 |
P28065 |
3.4.25.1
|
R-HSA-8951664
R-HSA-4608870
R-HSA-4608870
Reactome Name: Asymmetric localization of PCP proteins
See in Reactome
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-8852276
R-HSA-8852276
Reactome Name: The role of GTSE1 in G2/M progression after G2 checkpoint
See in Reactome
R-HSA-8941858
R-HSA-8941858
Reactome Name: Regulation of RUNX3 expression and activity
See in Reactome
R-HSA-174184
R-HSA-174184
Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A
See in Reactome
R-HSA-69017
R-HSA-69017
Reactome Name: CDK-mediated phosphorylation and removal of Cdc6
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-187577
R-HSA-187577
Reactome Name: SCF(Skp2)-mediated degradation of p27/p21
See in Reactome
R-HSA-1236978
R-HSA-1236978
Reactome Name: Cross-presentation of soluble exogenous antigens (endosomes)
See in Reactome
R-HSA-5610780
R-HSA-5610780
Reactome Name: Degradation of GLI1 by the proteasome
See in Reactome
R-HSA-5610785
R-HSA-5610785
Reactome Name: GLI3 is processed to GLI3R by the proteasome
See in Reactome
R-HSA-8854050
R-HSA-8854050
Reactome Name: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
See in Reactome
R-HSA-69601
R-HSA-69601
Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
See in Reactome
R-HSA-1236974
R-HSA-5610783
R-HSA-5610783
Reactome Name: Degradation of GLI2 by the proteasome
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5668541
R-HSA-5668541
Reactome Name: TNFR2 non-canonical NF-kB pathway
See in Reactome
R-HSA-1169091
R-HSA-1169091
Reactome Name: Activation of NF-kappaB in B cells
See in Reactome
R-HSA-4641258
R-HSA-9010553
R-HSA-9010553
Reactome Name: Regulation of expression of SLITs and ROBOs
See in Reactome
R-HSA-202424
R-HSA-450408
R-HSA-450408
Reactome Name: AUF1 (hnRNP D0) binds and destabilizes mRNA
See in Reactome
R-HSA-5687128
R-HSA-5676590
R-HSA-5676590
Reactome Name: NIK-->noncanonical NF-kB signaling
See in Reactome
R-HSA-1234176
R-HSA-1234176
Reactome Name: Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
See in Reactome
R-HSA-211733
R-HSA-211733
Reactome Name: Regulation of activated PAK-2p34 by proteasome mediated degradation
See in Reactome
R-HSA-4641257
R-HSA-5607761
R-HSA-5607761
Reactome Name: Dectin-1 mediated noncanonical NF-kB signaling
See in Reactome
R-HSA-5358346
R-HSA-5607764
R-HSA-8939236
R-HSA-8939236
Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs
See in Reactome
R-HSA-174178
R-HSA-174178
Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
See in Reactome
R-HSA-8939902
R-HSA-8939902
Reactome Name: Regulation of RUNX2 expression and activity
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-68949
R-HSA-69481
R-HSA-5658442
R-HSA-174154
R-HSA-174154
Reactome Name: APC/C:Cdc20 mediated degradation of Securin
See in Reactome
R-HSA-195253
R-HSA-195253
Reactome Name: Degradation of beta-catenin by the destruction complex
See in Reactome
R-HSA-174084
R-HSA-174084
Reactome Name: Autodegradation of Cdh1 by Cdh1:APC/C
See in Reactome
R-HSA-174113
R-HSA-174113
Reactome Name: SCF-beta-TrCP mediated degradation of Emi1
See in Reactome
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
R-HSA-350562
R-HSA-350562
Reactome Name: Regulation of ornithine decarboxylase (ODC)
See in Reactome
R-HSA-5632684
R-HSA-5689603
R-HSA-75815
R-HSA-75815
Reactome Name: Ubiquitin-dependent degradation of Cyclin D
See in Reactome
R-HSA-9020702
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-376176
R-HSA-449147
R-HSA-8953897
R-HSA-5688426
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-9013694
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-5358351
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5684996
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-174143
R-HSA-174143
Reactome Name: APC/C-mediated degradation of cell cycle proteins
See in Reactome
R-HSA-69052
R-HSA-69052
Reactome Name: Switching of origins to a post-replicative state
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-4086400
R-HSA-212436
R-HSA-74160
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-1234174
R-HSA-69278
R-HSA-69541
R-HSA-382551
R-HSA-179419
R-HSA-179419
Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
See in Reactome
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-5673001
R-HSA-202403
R-HSA-69239
R-HSA-446652
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-176408
R-HSA-176408
Reactome Name: Regulation of APC/C activators between G1/S and early anaphase
See in Reactome
R-HSA-176409
R-HSA-176409
Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-169911
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-9675108
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-8953854
R-HSA-168249
R-HSA-453274
R-HSA-392499
R-HSA-453276
R-HSA-453276
Reactome Name: Regulation of mitotic cell cycle
See in Reactome
R-HSA-68886
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-176814
R-HSA-176814
Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-5610787
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-157118
R-HSA-351202
R-HSA-69275
R-HSA-195721
R-HSA-69242
R-HSA-1257604
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-109581
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-69615
R-HSA-69306
R-HSA-69610
R-HSA-69610
Reactome Name: p53-Independent DNA Damage Response
See in Reactome
R-HSA-69613
R-HSA-69613
Reactome Name: p53-Independent G1/S DNA damage checkpoint
See in Reactome
R-HSA-71291
R-HSA-71291
Reactome Name: Metabolism of amino acids and derivatives
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-422475
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-162582
R-HSA-68882
|
Cellular responses to stimuli
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Transport of small molecules
Metabolism of RNA
Metabolism of proteins
DNA Replication
Signal Transduction
|
R-HSA-1168640
(
R-HSA-1169091
)
R-HSA-1234159
(
R-HSA-1234176
)
R-HSA-1234159
Reaction Name: Proteasome proteolyzes ub-HIF-alpha
See in Reactome
R-HSA-1236935
(
R-HSA-1236974
)
R-HSA-1236935
Reaction Name: Proteasomal cleavage of substrate
See in Reactome
R-HSA-1236970
(
R-HSA-1236978
)
R-HSA-1236970
Reaction Name: Proteasomal clevage of exogenous antigen
See in Reactome
R-HSA-1504193
(
R-HSA-4641258
)
R-HSA-1504193
Reaction Name: Ubiquitinated DVL is degraded by the proteasome
See in Reactome
R-HSA-174058
(
R-HSA-174084
)
R-HSA-174058
Reaction Name: Degradation of multiubiquitinated Cdh1
See in Reactome
R-HSA-174105
(
R-HSA-174178
)
R-HSA-174105
Reaction Name: Degradation of multiubiquitinated cell cycle proteins
See in Reactome
R-HSA-174202
(
R-HSA-174154;
R-HSA-2467813
)
R-HSA-174202
Reaction Name: Degradation of multiubiquitinated Securin
See in Reactome
R-HSA-174203
(
R-HSA-174113
)
R-HSA-174203
Reaction Name: SCF-mediated degradation of Emi1
See in Reactome
R-HSA-174255
(
R-HSA-174184
)
R-HSA-174255
Reaction Name: Degradation multiubiquitinated Cyclin A
See in Reactome
R-HSA-187574
(
R-HSA-187577
)
R-HSA-187574
Reaction Name: Degradation of ubiquitinated p27/p21 by the 26S proteasome
See in Reactome
R-HSA-188191
(
R-HSA-174178
)
R-HSA-188191
Reaction Name: APC/C:Cdh1-mediated degradation of Skp2
See in Reactome
R-HSA-209061
(
R-HSA-9020702
)
R-HSA-209061
Reaction Name: Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex
See in Reactome
R-HSA-211715
(
R-HSA-211733
)
R-HSA-211715
Reaction Name: Proteasome mediated degradation of PAK-2p34
See in Reactome
R-HSA-2130282
(
R-HSA-195253
)
R-HSA-2130282
Reaction Name: Degradation of ubiquitinated beta catenin by the proteasome
See in Reactome
R-HSA-264458
(
R-HSA-349425
)
R-HSA-264458
Reaction Name: Proteasome mediated degradation of COP1
See in Reactome
R-HSA-353125
(
R-HSA-350562
)
R-HSA-353125
Reaction Name: 26S proteosome degrades ODC holoenzyme complex
See in Reactome
R-HSA-3640874
(
R-HSA-4641257
)
R-HSA-3640874
Reaction Name: Ub-RibC-AXIN is degraded by the proteasome
See in Reactome
R-HSA-450466
(
R-HSA-450408
)
R-HSA-4608855
(
R-HSA-4608870
)
R-HSA-4608855
Reaction Name: PRICKLE1 is degraded by the proteasome
See in Reactome
R-HSA-4641256
(
R-HSA-4641257
)
R-HSA-4641256
Reaction Name: Ubiquitinated AXIN is degraded by the proteasome
See in Reactome
R-HSA-4641260
(
R-HSA-4641258
)
R-HSA-4641260
Reaction Name: Ubiquitinated DVL1 is degraded by the proteasome
See in Reactome
R-HSA-5362448
(
R-HSA-5358346
)
R-HSA-5362448
Reaction Name: Hh C-terminal fragments are degraded by the proteasome
See in Reactome
R-HSA-5607724
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-5607724
Reaction Name: 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex
See in Reactome
R-HSA-5607731
(
R-HSA-5607761;
R-HSA-5607764;
R-HSA-5668541;
R-HSA-5676590
)
R-HSA-5607731
Reaction Name: 26S proteasome processes p-7S-p100:RELB to form p52:RELB
See in Reactome
R-HSA-5610754
(
R-HSA-5610785
)
R-HSA-5610754
Reaction Name: GLI3 is partially degraded by the proteasome to yield the GLI3 repressor
See in Reactome
R-HSA-5610757
(
R-HSA-5610783
)
R-HSA-5610757
Reaction Name: GLI2 is degraded by the proteasome
See in Reactome
R-HSA-5610758
(
R-HSA-5610780
)
R-HSA-5610758
Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP
See in Reactome
R-HSA-5610760
(
R-HSA-5610780
)
R-HSA-5610760
Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by ITCH
See in Reactome
R-HSA-5635854
(
R-HSA-5632684
)
R-HSA-5635854
Reaction Name: GLI2,3 are degraded by the proteasome
See in Reactome
R-HSA-5635868
(
R-HSA-5632684
)
R-HSA-5635868
Reaction Name: ub-GLI is degraded by the proteasome
See in Reactome
R-HSA-5658430
(
R-HSA-5658442
)
R-HSA-5658430
Reaction Name: NF1 is degraded by the proteasome
See in Reactome
R-HSA-5665854
(
R-HSA-5689603
)
R-HSA-5665854
Reaction Name: ADRM1:26S proteaseome binds UCHL5
See in Reactome
R-HSA-5665871
(
R-HSA-5689603
)
R-HSA-5668481
(
R-HSA-5668541
)
R-HSA-5668481
Reaction Name: Protesomal degradation of K48polyUb-TRAF3
See in Reactome
R-HSA-5668520
(
R-HSA-5668541
)
R-HSA-5668520
Reaction Name: 26Sproteasome degrades K48polyUb-NIK
See in Reactome
R-HSA-5687112
(
R-HSA-5687128
)
R-HSA-5687112
Reaction Name: MAPK6 is degraded by the 26S proteasome
See in Reactome
R-HSA-5689539
(
R-HSA-5689880
)
R-HSA-5689539
Reaction Name: ADRM1:26S proteaseome binds USP14
See in Reactome
R-HSA-68825
()
R-HSA-68825
Reaction Name: Ubiquitinated geminin is degraded by the proteasome
See in Reactome
R-HSA-68948
(
R-HSA-68949
)
R-HSA-68948
Reaction Name: Ubiquitinated Orc1 is degraded by the proteasome
See in Reactome
R-HSA-69016
(
R-HSA-69017
)
R-HSA-69016
Reaction Name: Ubiquitinated Cdc6 is degraded by the proteasome
See in Reactome
R-HSA-69600
(
R-HSA-69601
)
R-HSA-69600
Reaction Name: Proteolytic degradation of ubiquitinated-Cdc25A
See in Reactome
R-HSA-75825
(
R-HSA-75815
)
R-HSA-75825
Reaction Name: Proteasome mediated degradation of Cyclin D1
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8852354
(
R-HSA-69481;
R-HSA-8852276
)
R-HSA-8852354
Reaction Name: GTSE1 facilitates proteasome-mediated degradation of TP53
See in Reactome
R-HSA-8854044
(
R-HSA-8854050
)
R-HSA-8854044
Reaction Name: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
See in Reactome
R-HSA-8854071
(
R-HSA-8854050
)
R-HSA-8854071
Reaction Name: Proteasome-mediated degradation of PolyUb-FBXL7
See in Reactome
R-HSA-8866553
(
R-HSA-382556
)
R-HSA-8866553
Reaction Name: misfolded CFTR is degraded by the 26S proteasome
See in Reactome
R-HSA-8932355
(
R-HSA-8951664
)
R-HSA-8932355
Reaction Name: 26S proteasome degrades Ub-NFE2L2
See in Reactome
R-HSA-8939801
(
R-HSA-8939902
)
R-HSA-8939801
Reaction Name: 26S proteasome degrades PolyUb-RUNX2
See in Reactome
R-HSA-8952408
(
R-HSA-8941858
)
R-HSA-8952408
Reaction Name: Polyubiquitinated RUNX3 is degraded by the proteasome
See in Reactome
R-HSA-8956140
(
R-HSA-8951664
)
R-HSA-8956140
Reaction Name: NEDD8 and UBD bind NUB1 and the 26S proteasome
See in Reactome
R-HSA-8956184
(
R-HSA-8951664
)
R-HSA-8956184
Reaction Name: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
See in Reactome
R-HSA-8957265
(
R-HSA-8939236
)
R-HSA-8957265
Reaction Name: 26S proteasome degrades TP73 polyubiquitinated by ITCH
See in Reactome
R-HSA-9008110
(
R-HSA-8939902
)
R-HSA-9008110
Reaction Name: Proteasome degrades polyubiquitinated RUNX2
See in Reactome
R-HSA-9008475
(
R-HSA-8939902
)
R-HSA-9008475
Reaction Name: Proteasome degrades polyubiquitinated RUNX2
See in Reactome
R-HSA-9009362
(
R-HSA-8939902
)
R-HSA-9009362
Reaction Name: Proteasome degrades PolyUb-RUNX2
See in Reactome
R-HSA-9011313
(
R-HSA-9010553
)
R-HSA-9011313
Reaction Name: Proteasome degrades ubiquitinated ROBO3.1
See in Reactome
R-HSA-9604642
(
R-HSA-9604323
)
R-HSA-9604642
Reaction Name: Proteasome degrades ubiquitinated NICD4
See in Reactome
R-HSA-9755303
(
R-HSA-8951664
)
R-HSA-9755303
Reaction Name: 26S proteasome degrades HIFalpha
See in Reactome
R-HSA-9755306
(
R-HSA-8951664
)
R-HSA-9755306
Reaction Name: ub UBXN7 is degraded by the 26S proteasome
See in Reactome
R-HSA-9762096
()
R-HSA-9762096
Reaction Name: Ub,pS335,S338,T NFE2L2 is degraded
See in Reactome
R-HSA-983150
(
R-HSA-983168
)
R-HSA-983150
Reaction Name: Proteasomal cleavage of substrate
See in Reactome
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