MONDO:0001149 |
MONDO:0001149
Disease Name: microcephaly
OMIM id: OMIM:612703
All associated enzymes in DAR:
DHCR7
UFSP2
PLA2G6
SLC2A1
RAG1
ALG13
DHX34
ATRX
RAG1 |
P15918 |
2.3.2.27
3.1.-.-
|
R-HSA-5687128
R-HSA-1266695
|
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-168256
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-162582
R-HSA-449147
|
Immune System
Signal Transduction
|
R-HSA-5692794
(
R-HSA-5687128
)
R-HSA-5692794
Reaction Name: p-S215 FOXO1 positively regulates RAG gene expression
See in Reactome
R-HSA-8865711
(
R-HSA-1266695
)
R-HSA-8865711
Reaction Name: RAG1:RAG2 recombinase binds immunoglobulin kappa locus in a BRWD1-dependent manner
See in Reactome
|
MONDO:0002529 |
RAC1 |
P63000 |
3.6.5.2
|
R-HSA-376172
R-HSA-445144
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-9619229
R-HSA-9619229
Reactome Name: Activation of RAC1 downstream of NMDARs
See in Reactome
R-HSA-428540
R-HSA-428543
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-399954
R-HSA-399954
Reactome Name: Sema3A PAK dependent Axon repulsion
See in Reactome
R-HSA-9032845
R-HSA-9032845
Reactome Name: Activated NTRK2 signals through CDK5
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-6798695
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-193648
R-HSA-193648
Reactome Name: NRAGE signals death through JNK
See in Reactome
R-HSA-5625900
R-HSA-5625740
R-HSA-9032759
R-HSA-1257604
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-389359
R-HSA-5627123
R-HSA-399955
R-HSA-399955
Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
See in Reactome
R-HSA-5626467
R-HSA-4420097
R-HSA-5663220
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5687128
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1433557
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-2424491
R-HSA-9013149
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-8875555
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-3928664
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-8848021
R-HSA-1280218
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9675108
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-112316
R-HSA-8875878
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-373760
R-HSA-9032500
R-HSA-9032500
Reactome Name: Activated NTRK2 signals through FYN
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-168249
R-HSA-195258
R-HSA-199991
R-HSA-73887
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-2682334
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-5653656
R-HSA-6806834
R-HSA-195721
R-HSA-2172127
R-HSA-204998
R-HSA-204998
Reactome Name: Cell death signalling via NRAGE, NRIF and NADE
See in Reactome
R-HSA-373755
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Developmental Biology
Neuronal System
Vesicle-mediated transport
Hemostasis
Signal Transduction
|
R-HSA-1011598
(
R-HSA-983231
)
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1433415
(
R-HSA-1433557
)
R-HSA-2029451
(
R-HSA-2029482
)
R-HSA-2029454
(
R-HSA-2029482
)
R-HSA-2029456
(
R-HSA-2029482;
R-HSA-5627123
)
R-HSA-2029465
(
R-HSA-2029482;
R-HSA-4420097;
R-HSA-5663213
)
R-HSA-2029465
Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)
See in Reactome
R-HSA-2029466
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029466
Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin
See in Reactome
R-HSA-2029467
(
R-HSA-2029482
)
R-HSA-2029467
Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO
See in Reactome
R-HSA-2029469
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029469
Reaction Name: p-ERK phosphorylates WAVEs and ABI
See in Reactome
R-HSA-205039
(
R-HSA-193648
)
R-HSA-205039
Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
See in Reactome
R-HSA-205136
(
R-HSA-193648
)
R-HSA-205136
Reaction Name: GTP-bound RAC contributes to JNK activation
See in Reactome
R-HSA-2130194
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2197690
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2316352
(
R-HSA-1445148
)
R-HSA-2316352
Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424476
(
R-HSA-2424491
)
R-HSA-2730840
(
R-HSA-2871796
)
R-HSA-2730856
(
R-HSA-2871796
)
R-HSA-2730889
(
R-HSA-2871796
)
R-HSA-2730889
Reaction Name: Recruitment of PAK to the membrane by binding active RAC1
See in Reactome
R-HSA-376123
(
R-HSA-376172
)
R-HSA-376123
Reaction Name: DSCAM associates with Rac1-GTP:pPAK1
See in Reactome
R-HSA-3858475
(
R-HSA-4086400
)
R-HSA-389348
(
R-HSA-389359
)
R-HSA-389788
(
R-HSA-389359;
R-HSA-5687128
)
R-HSA-389788
Reaction Name: Activation of PAKs by RAC1 and CDC42
See in Reactome
R-HSA-3928612
(
R-HSA-3928662
)
R-HSA-3928612
Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928619
(
R-HSA-3928662
)
R-HSA-3928620
(
R-HSA-3928662
)
R-HSA-3928625
(
R-HSA-3928664
)
R-HSA-3928628
(
R-HSA-3928665
)
R-HSA-3928628
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928633
(
R-HSA-3928664
)
R-HSA-3928633
Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it
See in Reactome
R-HSA-3928640
(
R-HSA-3928664
)
R-HSA-3928641
(
R-HSA-3928664
)
R-HSA-3928642
(
R-HSA-3928665
)
R-HSA-3928642
Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-399928
(
R-HSA-399955
)
R-HSA-399928
Reaction Name: Recruitment of Rnd1 to Plexin A
See in Reactome
R-HSA-399930
(
R-HSA-399954
)
R-HSA-399935
(
R-HSA-399955
)
R-HSA-399935
Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity
See in Reactome
R-HSA-399938
(
R-HSA-399955
)
R-HSA-399939
(
R-HSA-399954
)
R-HSA-399941
(
R-HSA-399955
)
R-HSA-399952
(
R-HSA-399954
)
R-HSA-399952
Reaction Name: Phosphorylation of LIMK-1 by PAK
See in Reactome
R-HSA-400682
(
R-HSA-416550
)
R-HSA-400682
Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D
See in Reactome
R-HSA-4093336
(
R-HSA-3928662
)
R-HSA-4093336
Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-428522
(
R-HSA-428543
)
R-HSA-428535
(
R-HSA-428540
)
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442592
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-442592
Reaction Name: WASPs or WAVEs activate the ARP2/3 complex
See in Reactome
R-HSA-445064
(
R-HSA-445144
)
R-HSA-445072
(
R-HSA-445144
)
R-HSA-445072
Reaction Name: Interaction of PAK1 with Rac1-GTP
See in Reactome
R-HSA-451347
(
R-HSA-376172
)
R-HSA-451366
(
R-HSA-376172
)
R-HSA-5218827
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218827
Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1
See in Reactome
R-HSA-5218839
(
R-HSA-4420097
)
R-HSA-5218839
Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1
See in Reactome
R-HSA-5218841
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218841
Reaction Name: NADPH oxidase 2 generates superoxide from oxygen
See in Reactome
R-HSA-5218850
(
R-HSA-4420097
)
R-HSA-5218850
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-5357445
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357472
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357483
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5626469
(
R-HSA-5626467
)
R-HSA-5626469
Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs
See in Reactome
R-HSA-5626507
(
R-HSA-5626467
)
R-HSA-5626507
Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin
See in Reactome
R-HSA-5626549
(
R-HSA-5626467
)
R-HSA-5627775
(
R-HSA-5627123;
R-HSA-5687128
)
R-HSA-5627775
Reaction Name: Autophosphorylation of PAK1,2,3
See in Reactome
R-HSA-5663232
(
R-HSA-5663220
)
R-HSA-5665659
(
R-HSA-5663220
)
R-HSA-5665659
Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin
See in Reactome
R-HSA-5665802
(
R-HSA-5663220
)
R-HSA-5665802
Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin
See in Reactome
R-HSA-5665809
(
R-HSA-5663220
)
R-HSA-5665809
Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments
See in Reactome
R-HSA-5668714
(
R-HSA-5668599
)
R-HSA-5668718
(
R-HSA-5668599
)
R-HSA-5668718
Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen
See in Reactome
R-HSA-5668731
(
R-HSA-5668599
)
R-HSA-5668731
Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen
See in Reactome
R-HSA-5668735
(
R-HSA-5668599
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5672304
(
R-HSA-5626467
)
R-HSA-5672304
Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1
See in Reactome
R-HSA-5672329
(
R-HSA-5626467
)
R-HSA-5672329
Reaction Name: IQGAP1 binds CLIP1 and microtubules
See in Reactome
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8848618
(
R-HSA-8849471
)
R-HSA-8848618
Reaction Name: Activation of RAC1 by the PXN:CRK complex
See in Reactome
R-HSA-8875591
(
R-HSA-8875555
)
R-HSA-8951586
(
R-HSA-4420097
)
R-HSA-8951586
Reaction Name: p-VAV family:PIP3 binds RAC1:GDP
See in Reactome
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981926
(
R-HSA-5627123
)
R-HSA-8981931
(
R-HSA-5627123
)
R-HSA-9013143
(
R-HSA-9013149
)
R-HSA-9013144
(
R-HSA-9013149
)
R-HSA-9013144
Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9013147
(
R-HSA-9013149
)
R-HSA-9013147
Reaction Name: RAC1 GDIs block activation of RAC1
See in Reactome
R-HSA-9032798
(
R-HSA-9032759
)
R-HSA-9033292
(
R-HSA-9032845
)
R-HSA-9033292
Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1
See in Reactome
R-HSA-9619803
(
R-HSA-9619229
)
R-HSA-9691168
(
R-HSA-9013149
)
R-HSA-9691168
Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane
See in Reactome
R-HSA-9691174
(
R-HSA-9013149
)
R-HSA-9691174
Reaction Name: RAC1 binds effectors at the ER membrane
See in Reactome
|
MONDO:0005012 |
RAC1 |
P63000 |
3.6.5.2
|
R-HSA-376172
R-HSA-445144
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-9619229
R-HSA-9619229
Reactome Name: Activation of RAC1 downstream of NMDARs
See in Reactome
R-HSA-428540
R-HSA-428543
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-399954
R-HSA-399954
Reactome Name: Sema3A PAK dependent Axon repulsion
See in Reactome
R-HSA-9032845
R-HSA-9032845
Reactome Name: Activated NTRK2 signals through CDK5
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-6798695
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-193648
R-HSA-193648
Reactome Name: NRAGE signals death through JNK
See in Reactome
R-HSA-5625900
R-HSA-5625740
R-HSA-9032759
R-HSA-1257604
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-389359
R-HSA-5627123
R-HSA-399955
R-HSA-399955
Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
See in Reactome
R-HSA-5626467
R-HSA-4420097
R-HSA-5663220
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5687128
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1433557
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-2424491
R-HSA-9013149
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-8875555
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-3928664
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-8848021
R-HSA-1280218
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9675108
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-112316
R-HSA-8875878
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-373760
R-HSA-9032500
R-HSA-9032500
Reactome Name: Activated NTRK2 signals through FYN
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-168249
R-HSA-195258
R-HSA-199991
R-HSA-73887
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-2682334
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-5653656
R-HSA-6806834
R-HSA-195721
R-HSA-2172127
R-HSA-204998
R-HSA-204998
Reactome Name: Cell death signalling via NRAGE, NRIF and NADE
See in Reactome
R-HSA-373755
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Developmental Biology
Neuronal System
Vesicle-mediated transport
Hemostasis
Signal Transduction
|
R-HSA-1011598
(
R-HSA-983231
)
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1433415
(
R-HSA-1433557
)
R-HSA-2029451
(
R-HSA-2029482
)
R-HSA-2029454
(
R-HSA-2029482
)
R-HSA-2029456
(
R-HSA-2029482;
R-HSA-5627123
)
R-HSA-2029465
(
R-HSA-2029482;
R-HSA-4420097;
R-HSA-5663213
)
R-HSA-2029465
Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)
See in Reactome
R-HSA-2029466
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029466
Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin
See in Reactome
R-HSA-2029467
(
R-HSA-2029482
)
R-HSA-2029467
Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO
See in Reactome
R-HSA-2029469
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029469
Reaction Name: p-ERK phosphorylates WAVEs and ABI
See in Reactome
R-HSA-205039
(
R-HSA-193648
)
R-HSA-205039
Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
See in Reactome
R-HSA-205136
(
R-HSA-193648
)
R-HSA-205136
Reaction Name: GTP-bound RAC contributes to JNK activation
See in Reactome
R-HSA-2130194
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2197690
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2316352
(
R-HSA-1445148
)
R-HSA-2316352
Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424476
(
R-HSA-2424491
)
R-HSA-2730840
(
R-HSA-2871796
)
R-HSA-2730856
(
R-HSA-2871796
)
R-HSA-2730889
(
R-HSA-2871796
)
R-HSA-2730889
Reaction Name: Recruitment of PAK to the membrane by binding active RAC1
See in Reactome
R-HSA-376123
(
R-HSA-376172
)
R-HSA-376123
Reaction Name: DSCAM associates with Rac1-GTP:pPAK1
See in Reactome
R-HSA-3858475
(
R-HSA-4086400
)
R-HSA-389348
(
R-HSA-389359
)
R-HSA-389788
(
R-HSA-389359;
R-HSA-5687128
)
R-HSA-389788
Reaction Name: Activation of PAKs by RAC1 and CDC42
See in Reactome
R-HSA-3928612
(
R-HSA-3928662
)
R-HSA-3928612
Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928619
(
R-HSA-3928662
)
R-HSA-3928620
(
R-HSA-3928662
)
R-HSA-3928625
(
R-HSA-3928664
)
R-HSA-3928628
(
R-HSA-3928665
)
R-HSA-3928628
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928633
(
R-HSA-3928664
)
R-HSA-3928633
Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it
See in Reactome
R-HSA-3928640
(
R-HSA-3928664
)
R-HSA-3928641
(
R-HSA-3928664
)
R-HSA-3928642
(
R-HSA-3928665
)
R-HSA-3928642
Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-399928
(
R-HSA-399955
)
R-HSA-399928
Reaction Name: Recruitment of Rnd1 to Plexin A
See in Reactome
R-HSA-399930
(
R-HSA-399954
)
R-HSA-399935
(
R-HSA-399955
)
R-HSA-399935
Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity
See in Reactome
R-HSA-399938
(
R-HSA-399955
)
R-HSA-399939
(
R-HSA-399954
)
R-HSA-399941
(
R-HSA-399955
)
R-HSA-399952
(
R-HSA-399954
)
R-HSA-399952
Reaction Name: Phosphorylation of LIMK-1 by PAK
See in Reactome
R-HSA-400682
(
R-HSA-416550
)
R-HSA-400682
Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D
See in Reactome
R-HSA-4093336
(
R-HSA-3928662
)
R-HSA-4093336
Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-428522
(
R-HSA-428543
)
R-HSA-428535
(
R-HSA-428540
)
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442592
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-442592
Reaction Name: WASPs or WAVEs activate the ARP2/3 complex
See in Reactome
R-HSA-445064
(
R-HSA-445144
)
R-HSA-445072
(
R-HSA-445144
)
R-HSA-445072
Reaction Name: Interaction of PAK1 with Rac1-GTP
See in Reactome
R-HSA-451347
(
R-HSA-376172
)
R-HSA-451366
(
R-HSA-376172
)
R-HSA-5218827
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218827
Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1
See in Reactome
R-HSA-5218839
(
R-HSA-4420097
)
R-HSA-5218839
Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1
See in Reactome
R-HSA-5218841
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218841
Reaction Name: NADPH oxidase 2 generates superoxide from oxygen
See in Reactome
R-HSA-5218850
(
R-HSA-4420097
)
R-HSA-5218850
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-5357445
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357472
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357483
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5626469
(
R-HSA-5626467
)
R-HSA-5626469
Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs
See in Reactome
R-HSA-5626507
(
R-HSA-5626467
)
R-HSA-5626507
Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin
See in Reactome
R-HSA-5626549
(
R-HSA-5626467
)
R-HSA-5627775
(
R-HSA-5627123;
R-HSA-5687128
)
R-HSA-5627775
Reaction Name: Autophosphorylation of PAK1,2,3
See in Reactome
R-HSA-5663232
(
R-HSA-5663220
)
R-HSA-5665659
(
R-HSA-5663220
)
R-HSA-5665659
Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin
See in Reactome
R-HSA-5665802
(
R-HSA-5663220
)
R-HSA-5665802
Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin
See in Reactome
R-HSA-5665809
(
R-HSA-5663220
)
R-HSA-5665809
Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments
See in Reactome
R-HSA-5668714
(
R-HSA-5668599
)
R-HSA-5668718
(
R-HSA-5668599
)
R-HSA-5668718
Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen
See in Reactome
R-HSA-5668731
(
R-HSA-5668599
)
R-HSA-5668731
Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen
See in Reactome
R-HSA-5668735
(
R-HSA-5668599
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5672304
(
R-HSA-5626467
)
R-HSA-5672304
Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1
See in Reactome
R-HSA-5672329
(
R-HSA-5626467
)
R-HSA-5672329
Reaction Name: IQGAP1 binds CLIP1 and microtubules
See in Reactome
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8848618
(
R-HSA-8849471
)
R-HSA-8848618
Reaction Name: Activation of RAC1 by the PXN:CRK complex
See in Reactome
R-HSA-8875591
(
R-HSA-8875555
)
R-HSA-8951586
(
R-HSA-4420097
)
R-HSA-8951586
Reaction Name: p-VAV family:PIP3 binds RAC1:GDP
See in Reactome
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981926
(
R-HSA-5627123
)
R-HSA-8981931
(
R-HSA-5627123
)
R-HSA-9013143
(
R-HSA-9013149
)
R-HSA-9013144
(
R-HSA-9013149
)
R-HSA-9013144
Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9013147
(
R-HSA-9013149
)
R-HSA-9013147
Reaction Name: RAC1 GDIs block activation of RAC1
See in Reactome
R-HSA-9032798
(
R-HSA-9032759
)
R-HSA-9033292
(
R-HSA-9032845
)
R-HSA-9033292
Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1
See in Reactome
R-HSA-9619803
(
R-HSA-9619229
)
R-HSA-9691168
(
R-HSA-9013149
)
R-HSA-9691168
Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane
See in Reactome
R-HSA-9691174
(
R-HSA-9013149
)
R-HSA-9691174
Reaction Name: RAC1 binds effectors at the ER membrane
See in Reactome
|
MONDO:0009306 |
RAG1 |
P15918 |
2.3.2.27
3.1.-.-
|
R-HSA-5687128
R-HSA-1266695
|
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-168256
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-162582
R-HSA-449147
|
Immune System
Signal Transduction
|
R-HSA-5692794
(
R-HSA-5687128
)
R-HSA-5692794
Reaction Name: p-S215 FOXO1 positively regulates RAG gene expression
See in Reactome
R-HSA-8865711
(
R-HSA-1266695
)
R-HSA-8865711
Reaction Name: RAG1:RAG2 recombinase binds immunoglobulin kappa locus in a BRWD1-dependent manner
See in Reactome
|
MONDO:0010150 |
RAC1 |
P63000 |
3.6.5.2
|
R-HSA-376172
R-HSA-445144
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-9619229
R-HSA-9619229
Reactome Name: Activation of RAC1 downstream of NMDARs
See in Reactome
R-HSA-428540
R-HSA-428543
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-399954
R-HSA-399954
Reactome Name: Sema3A PAK dependent Axon repulsion
See in Reactome
R-HSA-9032845
R-HSA-9032845
Reactome Name: Activated NTRK2 signals through CDK5
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-6798695
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-193648
R-HSA-193648
Reactome Name: NRAGE signals death through JNK
See in Reactome
R-HSA-5625900
R-HSA-5625740
R-HSA-9032759
R-HSA-1257604
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-389359
R-HSA-5627123
R-HSA-399955
R-HSA-399955
Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
See in Reactome
R-HSA-5626467
R-HSA-4420097
R-HSA-5663220
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5687128
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1433557
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-2424491
R-HSA-9013149
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-8875555
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-3928664
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-8848021
R-HSA-1280218
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9675108
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-112316
R-HSA-8875878
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-373760
R-HSA-9032500
R-HSA-9032500
Reactome Name: Activated NTRK2 signals through FYN
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-168249
R-HSA-195258
R-HSA-199991
R-HSA-73887
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-2682334
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-5653656
R-HSA-6806834
R-HSA-195721
R-HSA-2172127
R-HSA-204998
R-HSA-204998
Reactome Name: Cell death signalling via NRAGE, NRIF and NADE
See in Reactome
R-HSA-373755
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Developmental Biology
Neuronal System
Vesicle-mediated transport
Hemostasis
Signal Transduction
|
R-HSA-1011598
(
R-HSA-983231
)
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1433415
(
R-HSA-1433557
)
R-HSA-2029451
(
R-HSA-2029482
)
R-HSA-2029454
(
R-HSA-2029482
)
R-HSA-2029456
(
R-HSA-2029482;
R-HSA-5627123
)
R-HSA-2029465
(
R-HSA-2029482;
R-HSA-4420097;
R-HSA-5663213
)
R-HSA-2029465
Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)
See in Reactome
R-HSA-2029466
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029466
Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin
See in Reactome
R-HSA-2029467
(
R-HSA-2029482
)
R-HSA-2029467
Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO
See in Reactome
R-HSA-2029469
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029469
Reaction Name: p-ERK phosphorylates WAVEs and ABI
See in Reactome
R-HSA-205039
(
R-HSA-193648
)
R-HSA-205039
Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
See in Reactome
R-HSA-205136
(
R-HSA-193648
)
R-HSA-205136
Reaction Name: GTP-bound RAC contributes to JNK activation
See in Reactome
R-HSA-2130194
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2197690
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2316352
(
R-HSA-1445148
)
R-HSA-2316352
Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424476
(
R-HSA-2424491
)
R-HSA-2730840
(
R-HSA-2871796
)
R-HSA-2730856
(
R-HSA-2871796
)
R-HSA-2730889
(
R-HSA-2871796
)
R-HSA-2730889
Reaction Name: Recruitment of PAK to the membrane by binding active RAC1
See in Reactome
R-HSA-376123
(
R-HSA-376172
)
R-HSA-376123
Reaction Name: DSCAM associates with Rac1-GTP:pPAK1
See in Reactome
R-HSA-3858475
(
R-HSA-4086400
)
R-HSA-389348
(
R-HSA-389359
)
R-HSA-389788
(
R-HSA-389359;
R-HSA-5687128
)
R-HSA-389788
Reaction Name: Activation of PAKs by RAC1 and CDC42
See in Reactome
R-HSA-3928612
(
R-HSA-3928662
)
R-HSA-3928612
Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928619
(
R-HSA-3928662
)
R-HSA-3928620
(
R-HSA-3928662
)
R-HSA-3928625
(
R-HSA-3928664
)
R-HSA-3928628
(
R-HSA-3928665
)
R-HSA-3928628
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928633
(
R-HSA-3928664
)
R-HSA-3928633
Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it
See in Reactome
R-HSA-3928640
(
R-HSA-3928664
)
R-HSA-3928641
(
R-HSA-3928664
)
R-HSA-3928642
(
R-HSA-3928665
)
R-HSA-3928642
Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-399928
(
R-HSA-399955
)
R-HSA-399928
Reaction Name: Recruitment of Rnd1 to Plexin A
See in Reactome
R-HSA-399930
(
R-HSA-399954
)
R-HSA-399935
(
R-HSA-399955
)
R-HSA-399935
Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity
See in Reactome
R-HSA-399938
(
R-HSA-399955
)
R-HSA-399939
(
R-HSA-399954
)
R-HSA-399941
(
R-HSA-399955
)
R-HSA-399952
(
R-HSA-399954
)
R-HSA-399952
Reaction Name: Phosphorylation of LIMK-1 by PAK
See in Reactome
R-HSA-400682
(
R-HSA-416550
)
R-HSA-400682
Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D
See in Reactome
R-HSA-4093336
(
R-HSA-3928662
)
R-HSA-4093336
Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-428522
(
R-HSA-428543
)
R-HSA-428535
(
R-HSA-428540
)
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442592
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-442592
Reaction Name: WASPs or WAVEs activate the ARP2/3 complex
See in Reactome
R-HSA-445064
(
R-HSA-445144
)
R-HSA-445072
(
R-HSA-445144
)
R-HSA-445072
Reaction Name: Interaction of PAK1 with Rac1-GTP
See in Reactome
R-HSA-451347
(
R-HSA-376172
)
R-HSA-451366
(
R-HSA-376172
)
R-HSA-5218827
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218827
Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1
See in Reactome
R-HSA-5218839
(
R-HSA-4420097
)
R-HSA-5218839
Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1
See in Reactome
R-HSA-5218841
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218841
Reaction Name: NADPH oxidase 2 generates superoxide from oxygen
See in Reactome
R-HSA-5218850
(
R-HSA-4420097
)
R-HSA-5218850
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-5357445
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357472
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357483
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5626469
(
R-HSA-5626467
)
R-HSA-5626469
Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs
See in Reactome
R-HSA-5626507
(
R-HSA-5626467
)
R-HSA-5626507
Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin
See in Reactome
R-HSA-5626549
(
R-HSA-5626467
)
R-HSA-5627775
(
R-HSA-5627123;
R-HSA-5687128
)
R-HSA-5627775
Reaction Name: Autophosphorylation of PAK1,2,3
See in Reactome
R-HSA-5663232
(
R-HSA-5663220
)
R-HSA-5665659
(
R-HSA-5663220
)
R-HSA-5665659
Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin
See in Reactome
R-HSA-5665802
(
R-HSA-5663220
)
R-HSA-5665802
Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin
See in Reactome
R-HSA-5665809
(
R-HSA-5663220
)
R-HSA-5665809
Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments
See in Reactome
R-HSA-5668714
(
R-HSA-5668599
)
R-HSA-5668718
(
R-HSA-5668599
)
R-HSA-5668718
Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen
See in Reactome
R-HSA-5668731
(
R-HSA-5668599
)
R-HSA-5668731
Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen
See in Reactome
R-HSA-5668735
(
R-HSA-5668599
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5672304
(
R-HSA-5626467
)
R-HSA-5672304
Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1
See in Reactome
R-HSA-5672329
(
R-HSA-5626467
)
R-HSA-5672329
Reaction Name: IQGAP1 binds CLIP1 and microtubules
See in Reactome
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8848618
(
R-HSA-8849471
)
R-HSA-8848618
Reaction Name: Activation of RAC1 by the PXN:CRK complex
See in Reactome
R-HSA-8875591
(
R-HSA-8875555
)
R-HSA-8951586
(
R-HSA-4420097
)
R-HSA-8951586
Reaction Name: p-VAV family:PIP3 binds RAC1:GDP
See in Reactome
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981926
(
R-HSA-5627123
)
R-HSA-8981931
(
R-HSA-5627123
)
R-HSA-9013143
(
R-HSA-9013149
)
R-HSA-9013144
(
R-HSA-9013149
)
R-HSA-9013144
Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9013147
(
R-HSA-9013149
)
R-HSA-9013147
Reaction Name: RAC1 GDIs block activation of RAC1
See in Reactome
R-HSA-9032798
(
R-HSA-9032759
)
R-HSA-9033292
(
R-HSA-9032845
)
R-HSA-9033292
Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1
See in Reactome
R-HSA-9619803
(
R-HSA-9619229
)
R-HSA-9691168
(
R-HSA-9013149
)
R-HSA-9691168
Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane
See in Reactome
R-HSA-9691174
(
R-HSA-9013149
)
R-HSA-9691174
Reaction Name: RAC1 binds effectors at the ER membrane
See in Reactome
|
MONDO:0010361 |
PAK3 |
O75914 |
2.7.11.1
|
R-HSA-202433
R-HSA-202433
Reactome Name: Generation of second messenger molecules
See in Reactome
R-HSA-428540
R-HSA-3928664
R-HSA-5687128
R-HSA-399954
R-HSA-399954
Reactome Name: Sema3A PAK dependent Axon repulsion
See in Reactome
R-HSA-5621575
R-HSA-9013420
R-HSA-9013409
R-HSA-389359
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-9013148
R-HSA-9013149
R-HSA-5627123
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-1280218
R-HSA-1266738
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-194138
R-HSA-9675108
R-HSA-389356
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-202403
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-168249
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-2682334
R-HSA-195258
R-HSA-373755
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-162582
|
Immune System
Developmental Biology
Signal Transduction
|
R-HSA-389788
(
R-HSA-389359;
R-HSA-5687128
)
R-HSA-389788
Reaction Name: Activation of PAKs by RAC1 and CDC42
See in Reactome
R-HSA-3928625
(
R-HSA-3928664
)
R-HSA-3928640
(
R-HSA-3928664
)
R-HSA-3928641
(
R-HSA-3928664
)
R-HSA-399930
(
R-HSA-399954
)
R-HSA-399939
(
R-HSA-399954
)
R-HSA-399952
(
R-HSA-399954
)
R-HSA-399952
Reaction Name: Phosphorylation of LIMK-1 by PAK
See in Reactome
R-HSA-428531
(
R-HSA-428540
)
R-HSA-430183
(
R-HSA-202433
)
R-HSA-442832
(
R-HSA-5627123
)
R-HSA-5357445
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357472
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357477
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357477
Reaction Name: PAK1-3 phosphorylates VE-cadherin
See in Reactome
R-HSA-5357483
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5627775
(
R-HSA-5627123;
R-HSA-5687128
)
R-HSA-5627775
Reaction Name: Autophosphorylation of PAK1,2,3
See in Reactome
R-HSA-5687086
(
R-HSA-5687128
)
R-HSA-5687086
Reaction Name: PAK1,2,3 phosphorylates MAPK6,4
See in Reactome
R-HSA-8981926
(
R-HSA-5627123
)
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9013157
(
R-HSA-9013148
)
R-HSA-9013157
Reaction Name: CDC42 binds effectors at the plasma membrane
See in Reactome
R-HSA-9017507
(
R-HSA-9013409
)
R-HSA-9017507
Reaction Name: RHOJ binds effectors at the plasma membrane
See in Reactome
R-HSA-9018766
(
R-HSA-9013420
)
R-HSA-9018766
Reaction Name: RHOU binds effectors at the plasma membrane
See in Reactome
|
MONDO:0011086 |
RAG1 |
P15918 |
2.3.2.27
3.1.-.-
|
R-HSA-5687128
R-HSA-1266695
|
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-168256
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-162582
R-HSA-449147
|
Immune System
Signal Transduction
|
R-HSA-5692794
(
R-HSA-5687128
)
R-HSA-5692794
Reaction Name: p-S215 FOXO1 positively regulates RAG gene expression
See in Reactome
R-HSA-8865711
(
R-HSA-1266695
)
R-HSA-8865711
Reaction Name: RAG1:RAG2 recombinase binds immunoglobulin kappa locus in a BRWD1-dependent manner
See in Reactome
|
MONDO:0011338 |
RAG1 |
P15918 |
2.3.2.27
3.1.-.-
|
R-HSA-5687128
R-HSA-1266695
|
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-168256
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-162582
R-HSA-449147
|
Immune System
Signal Transduction
|
R-HSA-5692794
(
R-HSA-5687128
)
R-HSA-5692794
Reaction Name: p-S215 FOXO1 positively regulates RAG gene expression
See in Reactome
R-HSA-8865711
(
R-HSA-1266695
)
R-HSA-8865711
Reaction Name: RAG1:RAG2 recombinase binds immunoglobulin kappa locus in a BRWD1-dependent manner
See in Reactome
|
MONDO:0012091 |
CDC14A |
Q9UNH5 |
3.1.3.16
3.1.3.48
|
R-HSA-5687128
R-HSA-176407
R-HSA-176407
Reactome Name: Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
See in Reactome
|
R-HSA-174143
R-HSA-174143
Reactome Name: APC/C-mediated degradation of cell cycle proteins
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-453276
R-HSA-453276
Reactome Name: Regulation of mitotic cell cycle
See in Reactome
R-HSA-69278
R-HSA-1640170
R-HSA-162582
|
Cell Cycle
Signal Transduction
|
R-HSA-174124
(
R-HSA-176407
)
R-HSA-174124
Reaction Name: Dephosphorylation of phospho-Cdh1
See in Reactome
R-HSA-5692749
(
R-HSA-5687128
)
R-HSA-5692754
(
R-HSA-5687128
)
R-HSA-5692754
Reaction Name: CDC14A,B dephosphorylate p-3S,T MAPK6
See in Reactome
R-HSA-5692764
(
R-HSA-5687128
)
|
MONDO:0012359 |
RAG1 |
P15918 |
2.3.2.27
3.1.-.-
|
R-HSA-5687128
R-HSA-1266695
|
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-168256
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-162582
R-HSA-449147
|
Immune System
Signal Transduction
|
R-HSA-5692794
(
R-HSA-5687128
)
R-HSA-5692794
Reaction Name: p-S215 FOXO1 positively regulates RAG gene expression
See in Reactome
R-HSA-8865711
(
R-HSA-1266695
)
R-HSA-8865711
Reaction Name: RAG1:RAG2 recombinase binds immunoglobulin kappa locus in a BRWD1-dependent manner
See in Reactome
|
MONDO:0014359 |
PRKACA |
P17612 |
2.7.11.11
|
R-HSA-442720
R-HSA-442720
Reactome Name: CREB1 phosphorylation through the activation of Adenylate Cyclase
See in Reactome
R-HSA-9022692
R-HSA-9022692
Reactome Name: Regulation of MECP2 expression and activity
See in Reactome
R-HSA-381676
R-HSA-381676
Reactome Name: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
See in Reactome
R-HSA-380259
R-HSA-380259
Reactome Name: Loss of Nlp from mitotic centrosomes
See in Reactome
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-432040
R-HSA-432040
Reactome Name: Vasopressin regulates renal water homeostasis via Aquaporins
See in Reactome
R-HSA-380270
R-HSA-380270
Reactome Name: Recruitment of mitotic centrosome proteins and complexes
See in Reactome
R-HSA-5610783
R-HSA-5610783
Reactome Name: Degradation of GLI2 by the proteasome
See in Reactome
R-HSA-111931
R-HSA-111931
Reactome Name: PKA-mediated phosphorylation of CREB
See in Reactome
R-HSA-180024
R-HSA-5610787
R-HSA-163615
R-HSA-5610785
R-HSA-5610785
Reactome Name: GLI3 is processed to GLI3R by the proteasome
See in Reactome
R-HSA-164378
R-HSA-164378
Reactome Name: PKA activation in glucagon signalling
See in Reactome
R-HSA-5578775
R-HSA-8853659
R-HSA-9010642
R-HSA-8854518
R-HSA-4420097
R-HSA-380284
R-HSA-380284
Reactome Name: Loss of proteins required for interphase microtubule organization from the centrosome
See in Reactome
R-HSA-5687128
R-HSA-163560
R-HSA-5610780
R-HSA-5610780
Reactome Name: Degradation of GLI1 by the proteasome
See in Reactome
R-HSA-5620912
R-HSA-5620912
Reactome Name: Anchoring of the basal body to the plasma membrane
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-8963896
R-HSA-392517
R-HSA-163358
R-HSA-163358
Reactome Name: PKA-mediated phosphorylation of key metabolic factors
See in Reactome
R-HSA-422356
R-HSA-422356
Reactome Name: Regulation of insulin secretion
See in Reactome
R-HSA-2565942
R-HSA-2565942
Reactome Name: Regulation of PLK1 Activity at G2/M Transition
See in Reactome
R-HSA-380320
R-HSA-380320
Reactome Name: Recruitment of NuMA to mitotic centrosomes
See in Reactome
R-HSA-5621575
R-HSA-9634600
R-HSA-9634600
Reactome Name: Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
See in Reactome
|
R-HSA-376176
R-HSA-70326
R-HSA-111997
R-HSA-111996
R-HSA-397014
R-HSA-418594
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-168256
R-HSA-382551
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5358351
R-HSA-1640170
R-HSA-5617833
R-HSA-1280218
R-HSA-1266738
R-HSA-1489509
R-HSA-111933
R-HSA-71387
R-HSA-163359
R-HSA-163359
Reactome Name: Glucagon signaling in metabolic regulation
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-1852241
R-HSA-1852241
Reactome Name: Organelle biogenesis and maintenance
See in Reactome
R-HSA-449147
R-HSA-9675108
R-HSA-69278
R-HSA-8979227
R-HSA-112316
R-HSA-372790
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-69275
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-5576891
R-HSA-556833
R-HSA-174824
R-HSA-174824
Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance
See in Reactome
R-HSA-388396
R-HSA-380287
R-HSA-168249
R-HSA-163685
R-HSA-163685
Reactome Name: Integration of energy metabolism
See in Reactome
R-HSA-445717
R-HSA-453274
R-HSA-68886
R-HSA-70171
R-HSA-8963898
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-112043
R-HSA-112040
R-HSA-73857
R-HSA-111885
R-HSA-109582
R-HSA-194138
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-68877
R-HSA-162582
|
Muscle contraction
Immune System
Transport of small molecules
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Organelle biogenesis and maintenance
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-111919
(
R-HSA-111931;
R-HSA-442720
)
R-HSA-111924
(
R-HSA-111931;
R-HSA-442720
)
R-HSA-111924
Reaction Name: PKA catalytic subunit translocates to the nucleus
See in Reactome
R-HSA-111925
(
R-HSA-111931;
R-HSA-163615;
R-HSA-164378;
R-HSA-180024;
R-HSA-432040;
R-HSA-442720
)
R-HSA-111925
Reaction Name: cAMP induces dissociation of inactive PKA tetramers
See in Reactome
R-HSA-163416
(
R-HSA-163560
)
R-HSA-163416
Reaction Name: hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP
See in Reactome
R-HSA-163418
(
R-HSA-163560
)
R-HSA-163418
Reaction Name: perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP
See in Reactome
R-HSA-163672
(
R-HSA-163358
)
R-HSA-163672
Reaction Name: Phosphorylation of ChREBP at Thr(666) by PKA
See in Reactome
R-HSA-163676
(
R-HSA-163358
)
R-HSA-163676
Reaction Name: Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA
See in Reactome
R-HSA-163773
(
R-HSA-163358;
R-HSA-9634600
)
R-HSA-163773
Reaction Name: Phosphorylation of PF2K-Pase by PKA catalytic subunit
See in Reactome
R-HSA-177275
(
R-HSA-180024
)
R-HSA-177275
Reaction Name: PKA phosphorylates DARPP-32 on Thr34
See in Reactome
R-HSA-177284
(
R-HSA-180024
)
R-HSA-180073
(
R-HSA-180024
)
R-HSA-180073
Reaction Name: DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function
See in Reactome
R-HSA-2574840
(
R-HSA-2565942
)
R-HSA-2574840
Reaction Name: AJUBA facilitates AURKA autophosphorylation
See in Reactome
R-HSA-2574845
(
R-HSA-2565942
)
R-HSA-2574845
Reaction Name: AJUBA binds centrosome-associated AURKA
See in Reactome
R-HSA-265682
(
R-HSA-422356
)
R-HSA-265682
Reaction Name: KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel
See in Reactome
R-HSA-3000310
(
R-HSA-2565942
)
R-HSA-3000319
(
R-HSA-2565942
)
R-HSA-380272
(
R-HSA-380259;
R-HSA-380284
)
R-HSA-380272
Reaction Name: Plk1-mediated phosphorylation of Nlp
See in Reactome
R-HSA-380283
(
R-HSA-380270
)
R-HSA-380283
Reaction Name: Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
See in Reactome
R-HSA-380294
(
R-HSA-380284
)
R-HSA-380294
Reaction Name: Loss of C-Nap-1 from centrosomes
See in Reactome
R-HSA-380303
(
R-HSA-380259;
R-HSA-380284
)
R-HSA-380303
Reaction Name: Dissociation of Phospho-Nlp from the centrosome
See in Reactome
R-HSA-380311
(
R-HSA-380270
)
R-HSA-380311
Reaction Name: Recruitment of Plk1 to centrosomes
See in Reactome
R-HSA-380316
(
R-HSA-380320
)
R-HSA-380316
Reaction Name: Association of NuMA with microtubules
See in Reactome
R-HSA-380455
(
R-HSA-380270
)
R-HSA-380455
Reaction Name: Recruitment of CDK11p58 to the centrosomes
See in Reactome
R-HSA-380508
(
R-HSA-380320
)
R-HSA-380508
Reaction Name: Translocation of NuMA to the centrosomes
See in Reactome
R-HSA-381644
(
R-HSA-381676;
R-HSA-422356
)
R-HSA-381644
Reaction Name: ER calcium channels open in response to activated PKA
See in Reactome
R-HSA-381707
(
R-HSA-381676;
R-HSA-422356
)
R-HSA-381707
Reaction Name: PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP
See in Reactome
R-HSA-381713
(
R-HSA-381676;
R-HSA-422356
)
R-HSA-381713
Reaction Name: Potassium voltage-gated channels close in reponse to PKA
See in Reactome
R-HSA-432232
(
R-HSA-432040
)
R-HSA-432232
Reaction Name: Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)
See in Reactome
R-HSA-5218854
(
R-HSA-4420097
)
R-HSA-5218854
Reaction Name: p-Y420-FYN is phosphorylated on S21
See in Reactome
R-HSA-5610717
(
R-HSA-5610783;
R-HSA-5610787
)
R-HSA-5610720
(
R-HSA-5610785;
R-HSA-5610787
)
R-HSA-5610741
(
R-HSA-5610780;
R-HSA-5610787
)
R-HSA-5610749
(
R-HSA-5610787
)
R-HSA-5610749
Reaction Name: cAMP dissociates PKA, promoting GLI processing
See in Reactome
R-HSA-5617179
(
R-HSA-5578775
)
R-HSA-5617182
(
R-HSA-5578775
)
R-HSA-5617816
(
R-HSA-5620912
)
R-HSA-5617816
Reaction Name: RAB3IP stimulates nucleotide exchange on RAB8A
See in Reactome
R-HSA-5624473
(
R-HSA-5621575
)
R-HSA-5624473
Reaction Name: Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit
See in Reactome
R-HSA-5626220
(
R-HSA-5620912
)
R-HSA-5626220
Reaction Name: C2CD3 binds the mother centriole
See in Reactome
R-HSA-5626223
(
R-HSA-5620912
)
R-HSA-5626223
Reaction Name: C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole
See in Reactome
R-HSA-5626227
(
R-HSA-5620912
)
R-HSA-5626227
Reaction Name: CP110 and CEP97 dissociate from the centriole
See in Reactome
R-HSA-5626228
(
R-HSA-5620912
)
R-HSA-5626228
Reaction Name: The distal appendage proteins recruit TTBK2
See in Reactome
R-HSA-5626681
(
R-HSA-5620912
)
R-HSA-5626681
Reaction Name: Recruitment of transition zone proteins
See in Reactome
R-HSA-5626699
(
R-HSA-5620912
)
R-HSA-5626699
Reaction Name: MARK4 binds ODF2 in the centriole
See in Reactome
R-HSA-5638009
(
R-HSA-5620912
)
R-HSA-5638009
Reaction Name: CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body
See in Reactome
R-HSA-5682101
(
R-HSA-8963896
)
R-HSA-5682101
Reaction Name: PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer
See in Reactome
R-HSA-5687088
(
R-HSA-5687128
)
R-HSA-8853405
(
R-HSA-8854518
)
R-HSA-8853405
Reaction Name: TPX2 binds AURKA at centrosomes
See in Reactome
R-HSA-8853419
(
R-HSA-8854518
)
R-HSA-8853419
Reaction Name: TPX2 promotes AURKA autophosphorylation
See in Reactome
R-HSA-8854908
(
R-HSA-8853659
)
R-HSA-8854908
Reaction Name: PKA phosphorylates RET:GDNF:GFRA dimer
See in Reactome
R-HSA-8951727
(
R-HSA-111931;
R-HSA-163615;
R-HSA-180024;
R-HSA-432040;
R-HSA-442720
)
R-HSA-8986937
(
R-HSA-8986944;
R-HSA-9022692
)
R-HSA-8986937
Reaction Name: MECP2 is phosphorylated at T308
See in Reactome
R-HSA-8986939
(
R-HSA-8986944;
R-HSA-9022692
)
R-HSA-8986939
Reaction Name: MECP2 binds the NCoR/SMRT complex
See in Reactome
R-HSA-9010641
(
R-HSA-9010642
)
R-HSA-913451
(
R-HSA-512988
)
R-HSA-913451
Reaction Name: IL3RB is phosphorylated on Ser-585
See in Reactome
R-HSA-913996
(
R-HSA-392517
)
R-HSA-992708
(
R-HSA-983231
)
R-HSA-992708
Reaction Name: Dual-specific AKAPs bind type I and II PKA regulatory subunits
See in Reactome
|
MONDO:0014518 |
PRKACG |
P22612 |
2.7.11.11
|
R-HSA-442720
R-HSA-442720
Reactome Name: CREB1 phosphorylation through the activation of Adenylate Cyclase
See in Reactome
R-HSA-381676
R-HSA-381676
Reactome Name: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
See in Reactome
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-432040
R-HSA-432040
Reactome Name: Vasopressin regulates renal water homeostasis via Aquaporins
See in Reactome
R-HSA-5610783
R-HSA-5610783
Reactome Name: Degradation of GLI2 by the proteasome
See in Reactome
R-HSA-111931
R-HSA-111931
Reactome Name: PKA-mediated phosphorylation of CREB
See in Reactome
R-HSA-180024
R-HSA-5610787
R-HSA-163615
R-HSA-5610785
R-HSA-5610785
Reactome Name: GLI3 is processed to GLI3R by the proteasome
See in Reactome
R-HSA-164378
R-HSA-164378
Reactome Name: PKA activation in glucagon signalling
See in Reactome
R-HSA-8853659
R-HSA-9010642
R-HSA-4420097
R-HSA-9634600
R-HSA-9634600
Reactome Name: Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
See in Reactome
R-HSA-5687128
R-HSA-163560
R-HSA-5610780
R-HSA-5610780
Reactome Name: Degradation of GLI1 by the proteasome
See in Reactome
R-HSA-8963896
R-HSA-392517
R-HSA-163358
R-HSA-163358
Reactome Name: PKA-mediated phosphorylation of key metabolic factors
See in Reactome
R-HSA-422356
R-HSA-422356
Reactome Name: Regulation of insulin secretion
See in Reactome
R-HSA-5621575
|
R-HSA-376176
R-HSA-70326
R-HSA-111997
R-HSA-111996
R-HSA-418594
R-HSA-5358351
R-HSA-168256
R-HSA-382551
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-1280218
R-HSA-1266738
R-HSA-1489509
R-HSA-111933
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-194138
R-HSA-9675108
R-HSA-8979227
R-HSA-112316
R-HSA-372790
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-174824
R-HSA-174824
Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance
See in Reactome
R-HSA-388396
R-HSA-168249
R-HSA-163685
R-HSA-163685
Reactome Name: Integration of energy metabolism
See in Reactome
R-HSA-445717
R-HSA-556833
R-HSA-70171
R-HSA-8963898
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-163359
R-HSA-163359
Reactome Name: Glucagon signaling in metabolic regulation
See in Reactome
R-HSA-112043
R-HSA-112040
R-HSA-71387
R-HSA-111885
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Transport of small molecules
Metabolism
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-111919
(
R-HSA-111931;
R-HSA-442720
)
R-HSA-111924
(
R-HSA-111931;
R-HSA-442720
)
R-HSA-111924
Reaction Name: PKA catalytic subunit translocates to the nucleus
See in Reactome
R-HSA-111925
(
R-HSA-111931;
R-HSA-163615;
R-HSA-164378;
R-HSA-180024;
R-HSA-432040;
R-HSA-442720
)
R-HSA-111925
Reaction Name: cAMP induces dissociation of inactive PKA tetramers
See in Reactome
R-HSA-163416
(
R-HSA-163560
)
R-HSA-163416
Reaction Name: hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP
See in Reactome
R-HSA-163418
(
R-HSA-163560
)
R-HSA-163418
Reaction Name: perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP
See in Reactome
R-HSA-163672
(
R-HSA-163358
)
R-HSA-163672
Reaction Name: Phosphorylation of ChREBP at Thr(666) by PKA
See in Reactome
R-HSA-163676
(
R-HSA-163358
)
R-HSA-163676
Reaction Name: Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA
See in Reactome
R-HSA-163773
(
R-HSA-163358;
R-HSA-9634600
)
R-HSA-163773
Reaction Name: Phosphorylation of PF2K-Pase by PKA catalytic subunit
See in Reactome
R-HSA-177275
(
R-HSA-180024
)
R-HSA-177275
Reaction Name: PKA phosphorylates DARPP-32 on Thr34
See in Reactome
R-HSA-177284
(
R-HSA-180024
)
R-HSA-265682
(
R-HSA-422356
)
R-HSA-265682
Reaction Name: KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel
See in Reactome
R-HSA-381644
(
R-HSA-381676;
R-HSA-422356
)
R-HSA-381644
Reaction Name: ER calcium channels open in response to activated PKA
See in Reactome
R-HSA-381707
(
R-HSA-381676;
R-HSA-422356
)
R-HSA-381707
Reaction Name: PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP
See in Reactome
R-HSA-381713
(
R-HSA-381676;
R-HSA-422356
)
R-HSA-381713
Reaction Name: Potassium voltage-gated channels close in reponse to PKA
See in Reactome
R-HSA-432232
(
R-HSA-432040
)
R-HSA-432232
Reaction Name: Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)
See in Reactome
R-HSA-5218854
(
R-HSA-4420097
)
R-HSA-5218854
Reaction Name: p-Y420-FYN is phosphorylated on S21
See in Reactome
R-HSA-5610717
(
R-HSA-5610783;
R-HSA-5610787
)
R-HSA-5610720
(
R-HSA-5610785;
R-HSA-5610787
)
R-HSA-5610741
(
R-HSA-5610780;
R-HSA-5610787
)
R-HSA-5610749
(
R-HSA-5610787
)
R-HSA-5610749
Reaction Name: cAMP dissociates PKA, promoting GLI processing
See in Reactome
R-HSA-5624473
(
R-HSA-5621575
)
R-HSA-5624473
Reaction Name: Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit
See in Reactome
R-HSA-5682101
(
R-HSA-8963896
)
R-HSA-5682101
Reaction Name: PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer
See in Reactome
R-HSA-5687088
(
R-HSA-5687128
)
R-HSA-8854908
(
R-HSA-8853659
)
R-HSA-8854908
Reaction Name: PKA phosphorylates RET:GDNF:GFRA dimer
See in Reactome
R-HSA-8951727
(
R-HSA-111931;
R-HSA-163615;
R-HSA-180024;
R-HSA-432040;
R-HSA-442720
)
R-HSA-9010641
(
R-HSA-9010642
)
R-HSA-913996
(
R-HSA-392517
)
R-HSA-992708
(
R-HSA-983231
)
R-HSA-992708
Reaction Name: Dual-specific AKAPs bind type I and II PKA regulatory subunits
See in Reactome
|
MONDO:0014757 |
CDC42 |
P60953 |
3.6.5.2
|
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-428543
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-5627123
R-HSA-8950505
R-HSA-8950505
Reactome Name: Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
See in Reactome
R-HSA-389359
R-HSA-525793
R-HSA-5626467
R-HSA-4420097
R-HSA-5663220
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5687128
R-HSA-9013423
R-HSA-9013149
R-HSA-9013148
R-HSA-182971
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-9013424
R-HSA-9013420
R-HSA-5625970
R-HSA-9013408
R-HSA-9013409
R-HSA-9013406
R-HSA-9013404
R-HSA-8964616
R-HSA-8964616
Reactome Name: G beta:gamma signalling through CDC42
See in Reactome
|
R-HSA-376176
R-HSA-9012999
R-HSA-449147
R-HSA-168256
R-HSA-194315
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-1280218
R-HSA-1266738
R-HSA-2682334
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-389356
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-388396
R-HSA-168249
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9020591
R-HSA-177929
R-HSA-195258
R-HSA-372790
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-194138
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Developmental Biology
Hemostasis
Signal Transduction
|
R-HSA-1011598
(
R-HSA-983231
)
R-HSA-183002
(
R-HSA-182971
)
R-HSA-183002
Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85
See in Reactome
R-HSA-183084
(
R-HSA-182971
)
R-HSA-183084
Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix
See in Reactome
R-HSA-183094
(
R-HSA-182971
)
R-HSA-2029445
(
R-HSA-2029482
)
R-HSA-2029445
Reaction Name: An unknown GEF exchanges GTP for GDP on CDC42:GDP
See in Reactome
R-HSA-2029454
(
R-HSA-2029482
)
R-HSA-2029456
(
R-HSA-2029482;
R-HSA-5627123
)
R-HSA-2029466
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029466
Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin
See in Reactome
R-HSA-2197690
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2197691
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2197691
Reaction Name: WIP binds WASP,N-WASP, activating them
See in Reactome
R-HSA-2197698
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-376117
(
R-HSA-525793
)
R-HSA-376119
(
R-HSA-525793
)
R-HSA-376119
Reaction Name: Interaction of Bnip-2 with Cdc42
See in Reactome
R-HSA-389350
(
R-HSA-389359
)
R-HSA-389788
(
R-HSA-389359;
R-HSA-5687128
)
R-HSA-389788
Reaction Name: Activation of PAKs by RAC1 and CDC42
See in Reactome
R-HSA-3928595
(
R-HSA-3928662
)
R-HSA-3928595
Reaction Name: N-WASP binds ARP2/3 and G-actin
See in Reactome
R-HSA-3928601
(
R-HSA-3928662
)
R-HSA-3928601
Reaction Name: CDC42 and PIP2 bind WASL, activating it
See in Reactome
R-HSA-3928632
(
R-HSA-3928662
)
R-HSA-3928632
Reaction Name: ITSN1 exchanges GTP for GDP on CDC42, activating it
See in Reactome
R-HSA-418850
(
R-HSA-418885
)
R-HSA-418874
(
R-HSA-418885
)
R-HSA-418874
Reaction Name: Recruitment and activation of N-WASP by Cdc42
See in Reactome
R-HSA-428533
(
R-HSA-428543
)
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442586
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-442586
Reaction Name: Activation of WASP and N-WASP by CDC42
See in Reactome
R-HSA-442592
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-442592
Reaction Name: WASPs or WAVEs activate the ARP2/3 complex
See in Reactome
R-HSA-448951
(
R-HSA-525793
)
R-HSA-448951
Reaction Name: Activation of p38 alpha/beta MAPK
See in Reactome
R-HSA-448957
(
R-HSA-525793
)
R-HSA-448957
Reaction Name: Interaction of p38 MAPK with JLP
See in Reactome
R-HSA-448958
(
R-HSA-525793
)
R-HSA-448958
Reaction Name: Nuclear translocation of p38 MAPK
See in Reactome
R-HSA-449200
(
R-HSA-525793
)
R-HSA-449200
Reaction Name: Interaction of ABL1 with CDO complex
See in Reactome
R-HSA-5218804
(
R-HSA-4420097
)
R-HSA-5218812
(
R-HSA-4420097
)
R-HSA-5218814
(
R-HSA-4420097
)
R-HSA-5218829
(
R-HSA-4420097
)
R-HSA-5218829
Reaction Name: VEGF induces CDC42 activation by unknown mechanism
See in Reactome
R-HSA-5218832
(
R-HSA-4420097
)
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5626469
(
R-HSA-5626467
)
R-HSA-5626469
Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs
See in Reactome
R-HSA-5626507
(
R-HSA-5626467
)
R-HSA-5626507
Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin
See in Reactome
R-HSA-5626549
(
R-HSA-5626467
)
R-HSA-5627775
(
R-HSA-5627123;
R-HSA-5687128
)
R-HSA-5627775
Reaction Name: Autophosphorylation of PAK1,2,3
See in Reactome
R-HSA-5665686
(
R-HSA-5663220
)
R-HSA-5665727
(
R-HSA-5663220
)
R-HSA-5665751
(
R-HSA-5663220
)
R-HSA-5665751
Reaction Name: CDC42:GTP:FMNL2 binds Profilin:G-actin
See in Reactome
R-HSA-5666129
(
R-HSA-5663220
)
R-HSA-5666129
Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores
See in Reactome
R-HSA-5666160
(
R-HSA-5663220
)
R-HSA-5666160
Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores
See in Reactome
R-HSA-5666169
(
R-HSA-5663220
)
R-HSA-5666169
Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
See in Reactome
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5672304
(
R-HSA-5626467
)
R-HSA-5672304
Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1
See in Reactome
R-HSA-5672329
(
R-HSA-5626467
)
R-HSA-5672329
Reaction Name: IQGAP1 binds CLIP1 and microtubules
See in Reactome
R-HSA-8950637
(
R-HSA-8950505
)
R-HSA-8950637
Reaction Name: Expression of cell division cycle 42
See in Reactome
R-HSA-8951490
(
R-HSA-182971
)
R-HSA-8951490
Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85
See in Reactome
R-HSA-8964599
(
R-HSA-8964616
)
R-HSA-8964599
Reaction Name: Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex
See in Reactome
R-HSA-8964604
(
R-HSA-8964616
)
R-HSA-8964604
Reaction Name: CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated
See in Reactome
R-HSA-8964614
(
R-HSA-8964616
)
R-HSA-8964614
Reaction Name: PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated
See in Reactome
R-HSA-8964634
(
R-HSA-8964616
)
R-HSA-8964634
Reaction Name: CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex
See in Reactome
R-HSA-8981926
(
R-HSA-5627123
)
R-HSA-8981931
(
R-HSA-5627123
)
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9013157
(
R-HSA-9013148
)
R-HSA-9013157
Reaction Name: CDC42 binds effectors at the plasma membrane
See in Reactome
R-HSA-9013158
(
R-HSA-9013148
)
R-HSA-9013158
Reaction Name: CDC42 GDIs block activation of CDC42
See in Reactome
R-HSA-9013159
(
R-HSA-9013148
)
R-HSA-9013161
(
R-HSA-9013148
)
R-HSA-9013161
Reaction Name: CDC42 GAPs stimulate CDC42 GTPase activity
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014449
(
R-HSA-9013408
)
R-HSA-9014449
Reaction Name: RHOG binds effectors at the plasma membrane
See in Reactome
R-HSA-9017507
(
R-HSA-9013409
)
R-HSA-9017507
Reaction Name: RHOJ binds effectors at the plasma membrane
See in Reactome
R-HSA-9018746
(
R-HSA-9013406
)
R-HSA-9018746
Reaction Name: RHOQ binds effectors at the plasma membrane
See in Reactome
R-HSA-9018766
(
R-HSA-9013420
)
R-HSA-9018766
Reaction Name: RHOU binds effectors at the plasma membrane
See in Reactome
R-HSA-9018794
(
R-HSA-9013424
)
R-HSA-9018794
Reaction Name: RHOV binds effectors at the plasma membrane
See in Reactome
R-HSA-9018808
(
R-HSA-9013423
)
R-HSA-9018808
Reaction Name: RAC3 binds effectors at the plasma membrane
See in Reactome
R-HSA-9692800
(
R-HSA-9013148
)
R-HSA-9692800
Reaction Name: CDC42 translocates to the endoplasmic reticulum membrane
See in Reactome
R-HSA-9692809
(
R-HSA-9013148
)
R-HSA-9692809
Reaction Name: CDC42 binds effectors at the ER membrane
See in Reactome
|
MONDO:0030876 |
PRKACA |
P17612 |
2.7.11.11
|
R-HSA-442720
R-HSA-442720
Reactome Name: CREB1 phosphorylation through the activation of Adenylate Cyclase
See in Reactome
R-HSA-9022692
R-HSA-9022692
Reactome Name: Regulation of MECP2 expression and activity
See in Reactome
R-HSA-381676
R-HSA-381676
Reactome Name: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
See in Reactome
R-HSA-380259
R-HSA-380259
Reactome Name: Loss of Nlp from mitotic centrosomes
See in Reactome
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-432040
R-HSA-432040
Reactome Name: Vasopressin regulates renal water homeostasis via Aquaporins
See in Reactome
R-HSA-380270
R-HSA-380270
Reactome Name: Recruitment of mitotic centrosome proteins and complexes
See in Reactome
R-HSA-5610783
R-HSA-5610783
Reactome Name: Degradation of GLI2 by the proteasome
See in Reactome
R-HSA-111931
R-HSA-111931
Reactome Name: PKA-mediated phosphorylation of CREB
See in Reactome
R-HSA-180024
R-HSA-5610787
R-HSA-163615
R-HSA-5610785
R-HSA-5610785
Reactome Name: GLI3 is processed to GLI3R by the proteasome
See in Reactome
R-HSA-164378
R-HSA-164378
Reactome Name: PKA activation in glucagon signalling
See in Reactome
R-HSA-5578775
R-HSA-8853659
R-HSA-9010642
R-HSA-8854518
R-HSA-4420097
R-HSA-380284
R-HSA-380284
Reactome Name: Loss of proteins required for interphase microtubule organization from the centrosome
See in Reactome
R-HSA-5687128
R-HSA-163560
R-HSA-5610780
R-HSA-5610780
Reactome Name: Degradation of GLI1 by the proteasome
See in Reactome
R-HSA-5620912
R-HSA-5620912
Reactome Name: Anchoring of the basal body to the plasma membrane
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-8963896
R-HSA-392517
R-HSA-163358
R-HSA-163358
Reactome Name: PKA-mediated phosphorylation of key metabolic factors
See in Reactome
R-HSA-422356
R-HSA-422356
Reactome Name: Regulation of insulin secretion
See in Reactome
R-HSA-2565942
R-HSA-2565942
Reactome Name: Regulation of PLK1 Activity at G2/M Transition
See in Reactome
R-HSA-380320
R-HSA-380320
Reactome Name: Recruitment of NuMA to mitotic centrosomes
See in Reactome
R-HSA-5621575
R-HSA-9634600
R-HSA-9634600
Reactome Name: Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
See in Reactome
|
R-HSA-376176
R-HSA-70326
R-HSA-111997
R-HSA-111996
R-HSA-397014
R-HSA-418594
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-168256
R-HSA-382551
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5358351
R-HSA-1640170
R-HSA-5617833
R-HSA-1280218
R-HSA-1266738
R-HSA-1489509
R-HSA-111933
R-HSA-71387
R-HSA-163359
R-HSA-163359
Reactome Name: Glucagon signaling in metabolic regulation
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-1852241
R-HSA-1852241
Reactome Name: Organelle biogenesis and maintenance
See in Reactome
R-HSA-449147
R-HSA-9675108
R-HSA-69278
R-HSA-8979227
R-HSA-112316
R-HSA-372790
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-69275
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-5576891
R-HSA-556833
R-HSA-174824
R-HSA-174824
Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance
See in Reactome
R-HSA-388396
R-HSA-380287
R-HSA-168249
R-HSA-163685
R-HSA-163685
Reactome Name: Integration of energy metabolism
See in Reactome
R-HSA-445717
R-HSA-453274
R-HSA-68886
R-HSA-70171
R-HSA-8963898
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-112043
R-HSA-112040
R-HSA-73857
R-HSA-111885
R-HSA-109582
R-HSA-194138
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-68877
R-HSA-162582
|
Muscle contraction
Immune System
Transport of small molecules
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Organelle biogenesis and maintenance
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-111919
(
R-HSA-111931;
R-HSA-442720
)
R-HSA-111924
(
R-HSA-111931;
R-HSA-442720
)
R-HSA-111924
Reaction Name: PKA catalytic subunit translocates to the nucleus
See in Reactome
R-HSA-111925
(
R-HSA-111931;
R-HSA-163615;
R-HSA-164378;
R-HSA-180024;
R-HSA-432040;
R-HSA-442720
)
R-HSA-111925
Reaction Name: cAMP induces dissociation of inactive PKA tetramers
See in Reactome
R-HSA-163416
(
R-HSA-163560
)
R-HSA-163416
Reaction Name: hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP
See in Reactome
R-HSA-163418
(
R-HSA-163560
)
R-HSA-163418
Reaction Name: perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP
See in Reactome
R-HSA-163672
(
R-HSA-163358
)
R-HSA-163672
Reaction Name: Phosphorylation of ChREBP at Thr(666) by PKA
See in Reactome
R-HSA-163676
(
R-HSA-163358
)
R-HSA-163676
Reaction Name: Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA
See in Reactome
R-HSA-163773
(
R-HSA-163358;
R-HSA-9634600
)
R-HSA-163773
Reaction Name: Phosphorylation of PF2K-Pase by PKA catalytic subunit
See in Reactome
R-HSA-177275
(
R-HSA-180024
)
R-HSA-177275
Reaction Name: PKA phosphorylates DARPP-32 on Thr34
See in Reactome
R-HSA-177284
(
R-HSA-180024
)
R-HSA-180073
(
R-HSA-180024
)
R-HSA-180073
Reaction Name: DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function
See in Reactome
R-HSA-2574840
(
R-HSA-2565942
)
R-HSA-2574840
Reaction Name: AJUBA facilitates AURKA autophosphorylation
See in Reactome
R-HSA-2574845
(
R-HSA-2565942
)
R-HSA-2574845
Reaction Name: AJUBA binds centrosome-associated AURKA
See in Reactome
R-HSA-265682
(
R-HSA-422356
)
R-HSA-265682
Reaction Name: KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel
See in Reactome
R-HSA-3000310
(
R-HSA-2565942
)
R-HSA-3000319
(
R-HSA-2565942
)
R-HSA-380272
(
R-HSA-380259;
R-HSA-380284
)
R-HSA-380272
Reaction Name: Plk1-mediated phosphorylation of Nlp
See in Reactome
R-HSA-380283
(
R-HSA-380270
)
R-HSA-380283
Reaction Name: Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
See in Reactome
R-HSA-380294
(
R-HSA-380284
)
R-HSA-380294
Reaction Name: Loss of C-Nap-1 from centrosomes
See in Reactome
R-HSA-380303
(
R-HSA-380259;
R-HSA-380284
)
R-HSA-380303
Reaction Name: Dissociation of Phospho-Nlp from the centrosome
See in Reactome
R-HSA-380311
(
R-HSA-380270
)
R-HSA-380311
Reaction Name: Recruitment of Plk1 to centrosomes
See in Reactome
R-HSA-380316
(
R-HSA-380320
)
R-HSA-380316
Reaction Name: Association of NuMA with microtubules
See in Reactome
R-HSA-380455
(
R-HSA-380270
)
R-HSA-380455
Reaction Name: Recruitment of CDK11p58 to the centrosomes
See in Reactome
R-HSA-380508
(
R-HSA-380320
)
R-HSA-380508
Reaction Name: Translocation of NuMA to the centrosomes
See in Reactome
R-HSA-381644
(
R-HSA-381676;
R-HSA-422356
)
R-HSA-381644
Reaction Name: ER calcium channels open in response to activated PKA
See in Reactome
R-HSA-381707
(
R-HSA-381676;
R-HSA-422356
)
R-HSA-381707
Reaction Name: PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP
See in Reactome
R-HSA-381713
(
R-HSA-381676;
R-HSA-422356
)
R-HSA-381713
Reaction Name: Potassium voltage-gated channels close in reponse to PKA
See in Reactome
R-HSA-432232
(
R-HSA-432040
)
R-HSA-432232
Reaction Name: Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)
See in Reactome
R-HSA-5218854
(
R-HSA-4420097
)
R-HSA-5218854
Reaction Name: p-Y420-FYN is phosphorylated on S21
See in Reactome
R-HSA-5610717
(
R-HSA-5610783;
R-HSA-5610787
)
R-HSA-5610720
(
R-HSA-5610785;
R-HSA-5610787
)
R-HSA-5610741
(
R-HSA-5610780;
R-HSA-5610787
)
R-HSA-5610749
(
R-HSA-5610787
)
R-HSA-5610749
Reaction Name: cAMP dissociates PKA, promoting GLI processing
See in Reactome
R-HSA-5617179
(
R-HSA-5578775
)
R-HSA-5617182
(
R-HSA-5578775
)
R-HSA-5617816
(
R-HSA-5620912
)
R-HSA-5617816
Reaction Name: RAB3IP stimulates nucleotide exchange on RAB8A
See in Reactome
R-HSA-5624473
(
R-HSA-5621575
)
R-HSA-5624473
Reaction Name: Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit
See in Reactome
R-HSA-5626220
(
R-HSA-5620912
)
R-HSA-5626220
Reaction Name: C2CD3 binds the mother centriole
See in Reactome
R-HSA-5626223
(
R-HSA-5620912
)
R-HSA-5626223
Reaction Name: C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole
See in Reactome
R-HSA-5626227
(
R-HSA-5620912
)
R-HSA-5626227
Reaction Name: CP110 and CEP97 dissociate from the centriole
See in Reactome
R-HSA-5626228
(
R-HSA-5620912
)
R-HSA-5626228
Reaction Name: The distal appendage proteins recruit TTBK2
See in Reactome
R-HSA-5626681
(
R-HSA-5620912
)
R-HSA-5626681
Reaction Name: Recruitment of transition zone proteins
See in Reactome
R-HSA-5626699
(
R-HSA-5620912
)
R-HSA-5626699
Reaction Name: MARK4 binds ODF2 in the centriole
See in Reactome
R-HSA-5638009
(
R-HSA-5620912
)
R-HSA-5638009
Reaction Name: CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body
See in Reactome
R-HSA-5682101
(
R-HSA-8963896
)
R-HSA-5682101
Reaction Name: PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer
See in Reactome
R-HSA-5687088
(
R-HSA-5687128
)
R-HSA-8853405
(
R-HSA-8854518
)
R-HSA-8853405
Reaction Name: TPX2 binds AURKA at centrosomes
See in Reactome
R-HSA-8853419
(
R-HSA-8854518
)
R-HSA-8853419
Reaction Name: TPX2 promotes AURKA autophosphorylation
See in Reactome
R-HSA-8854908
(
R-HSA-8853659
)
R-HSA-8854908
Reaction Name: PKA phosphorylates RET:GDNF:GFRA dimer
See in Reactome
R-HSA-8951727
(
R-HSA-111931;
R-HSA-163615;
R-HSA-180024;
R-HSA-432040;
R-HSA-442720
)
R-HSA-8986937
(
R-HSA-8986944;
R-HSA-9022692
)
R-HSA-8986937
Reaction Name: MECP2 is phosphorylated at T308
See in Reactome
R-HSA-8986939
(
R-HSA-8986944;
R-HSA-9022692
)
R-HSA-8986939
Reaction Name: MECP2 binds the NCoR/SMRT complex
See in Reactome
R-HSA-9010641
(
R-HSA-9010642
)
R-HSA-913451
(
R-HSA-512988
)
R-HSA-913451
Reaction Name: IL3RB is phosphorylated on Ser-585
See in Reactome
R-HSA-913996
(
R-HSA-392517
)
R-HSA-992708
(
R-HSA-983231
)
R-HSA-992708
Reaction Name: Dual-specific AKAPs bind type I and II PKA regulatory subunits
See in Reactome
|
MONDO:0030877 |
PRKACB |
P22694 |
2.7.11.11
|
R-HSA-442720
R-HSA-442720
Reactome Name: CREB1 phosphorylation through the activation of Adenylate Cyclase
See in Reactome
R-HSA-381676
R-HSA-381676
Reactome Name: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
See in Reactome
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-432040
R-HSA-432040
Reactome Name: Vasopressin regulates renal water homeostasis via Aquaporins
See in Reactome
R-HSA-5610783
R-HSA-5610783
Reactome Name: Degradation of GLI2 by the proteasome
See in Reactome
R-HSA-111931
R-HSA-111931
Reactome Name: PKA-mediated phosphorylation of CREB
See in Reactome
R-HSA-180024
R-HSA-5610787
R-HSA-163615
R-HSA-5610785
R-HSA-5610785
Reactome Name: GLI3 is processed to GLI3R by the proteasome
See in Reactome
R-HSA-164378
R-HSA-164378
Reactome Name: PKA activation in glucagon signalling
See in Reactome
R-HSA-8853659
R-HSA-9010642
R-HSA-4420097
R-HSA-9634600
R-HSA-9634600
Reactome Name: Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
See in Reactome
R-HSA-5687128
R-HSA-163560
R-HSA-5610780
R-HSA-5610780
Reactome Name: Degradation of GLI1 by the proteasome
See in Reactome
R-HSA-8963896
R-HSA-392517
R-HSA-163358
R-HSA-163358
Reactome Name: PKA-mediated phosphorylation of key metabolic factors
See in Reactome
R-HSA-422356
R-HSA-422356
Reactome Name: Regulation of insulin secretion
See in Reactome
R-HSA-5621575
|
R-HSA-376176
R-HSA-70326
R-HSA-111997
R-HSA-111996
R-HSA-418594
R-HSA-5358351
R-HSA-168256
R-HSA-382551
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-1280218
R-HSA-1266738
R-HSA-1489509
R-HSA-111933
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-194138
R-HSA-9675108
R-HSA-8979227
R-HSA-112316
R-HSA-372790
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-174824
R-HSA-174824
Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance
See in Reactome
R-HSA-388396
R-HSA-168249
R-HSA-163685
R-HSA-163685
Reactome Name: Integration of energy metabolism
See in Reactome
R-HSA-445717
R-HSA-556833
R-HSA-70171
R-HSA-8963898
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-163359
R-HSA-163359
Reactome Name: Glucagon signaling in metabolic regulation
See in Reactome
R-HSA-112043
R-HSA-112040
R-HSA-71387
R-HSA-111885
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Transport of small molecules
Metabolism
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-111919
(
R-HSA-111931;
R-HSA-442720
)
R-HSA-111924
(
R-HSA-111931;
R-HSA-442720
)
R-HSA-111924
Reaction Name: PKA catalytic subunit translocates to the nucleus
See in Reactome
R-HSA-111925
(
R-HSA-111931;
R-HSA-163615;
R-HSA-164378;
R-HSA-180024;
R-HSA-432040;
R-HSA-442720
)
R-HSA-111925
Reaction Name: cAMP induces dissociation of inactive PKA tetramers
See in Reactome
R-HSA-163416
(
R-HSA-163560
)
R-HSA-163416
Reaction Name: hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP
See in Reactome
R-HSA-163418
(
R-HSA-163560
)
R-HSA-163418
Reaction Name: perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP
See in Reactome
R-HSA-163672
(
R-HSA-163358
)
R-HSA-163672
Reaction Name: Phosphorylation of ChREBP at Thr(666) by PKA
See in Reactome
R-HSA-163676
(
R-HSA-163358
)
R-HSA-163676
Reaction Name: Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA
See in Reactome
R-HSA-163773
(
R-HSA-163358;
R-HSA-9634600
)
R-HSA-163773
Reaction Name: Phosphorylation of PF2K-Pase by PKA catalytic subunit
See in Reactome
R-HSA-177275
(
R-HSA-180024
)
R-HSA-177275
Reaction Name: PKA phosphorylates DARPP-32 on Thr34
See in Reactome
R-HSA-177284
(
R-HSA-180024
)
R-HSA-265682
(
R-HSA-422356
)
R-HSA-265682
Reaction Name: KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel
See in Reactome
R-HSA-381644
(
R-HSA-381676;
R-HSA-422356
)
R-HSA-381644
Reaction Name: ER calcium channels open in response to activated PKA
See in Reactome
R-HSA-381707
(
R-HSA-381676;
R-HSA-422356
)
R-HSA-381707
Reaction Name: PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP
See in Reactome
R-HSA-381713
(
R-HSA-381676;
R-HSA-422356
)
R-HSA-381713
Reaction Name: Potassium voltage-gated channels close in reponse to PKA
See in Reactome
R-HSA-432232
(
R-HSA-432040
)
R-HSA-432232
Reaction Name: Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)
See in Reactome
R-HSA-5218854
(
R-HSA-4420097
)
R-HSA-5218854
Reaction Name: p-Y420-FYN is phosphorylated on S21
See in Reactome
R-HSA-5610717
(
R-HSA-5610783;
R-HSA-5610787
)
R-HSA-5610720
(
R-HSA-5610785;
R-HSA-5610787
)
R-HSA-5610741
(
R-HSA-5610780;
R-HSA-5610787
)
R-HSA-5610749
(
R-HSA-5610787
)
R-HSA-5610749
Reaction Name: cAMP dissociates PKA, promoting GLI processing
See in Reactome
R-HSA-5624473
(
R-HSA-5621575
)
R-HSA-5624473
Reaction Name: Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit
See in Reactome
R-HSA-5682101
(
R-HSA-8963896
)
R-HSA-5682101
Reaction Name: PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer
See in Reactome
R-HSA-5687088
(
R-HSA-5687128
)
R-HSA-8854908
(
R-HSA-8853659
)
R-HSA-8854908
Reaction Name: PKA phosphorylates RET:GDNF:GFRA dimer
See in Reactome
R-HSA-8951727
(
R-HSA-111931;
R-HSA-163615;
R-HSA-180024;
R-HSA-432040;
R-HSA-442720
)
R-HSA-9010641
(
R-HSA-9010642
)
R-HSA-913996
(
R-HSA-392517
)
R-HSA-992708
(
R-HSA-983231
)
R-HSA-992708
Reaction Name: Dual-specific AKAPs bind type I and II PKA regulatory subunits
See in Reactome
|
MONDO:0030897 |
AGO2 |
Q9UKV8 |
3.1.26.n2
|
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-426486
R-HSA-426486
Reactome Name: Small interfering RNA (siRNA) biogenesis
See in Reactome
R-HSA-9029569
R-HSA-9029569
Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
R-HSA-1912408
R-HSA-1912408
Reactome Name: Pre-NOTCH Transcription and Translation
See in Reactome
R-HSA-8948700
R-HSA-8948700
Reactome Name: Competing endogenous RNAs (ceRNAs) regulate PTEN translation
See in Reactome
R-HSA-203927
R-HSA-9022692
R-HSA-9022692
Reactome Name: Regulation of MECP2 expression and activity
See in Reactome
R-HSA-9018519
R-HSA-9018519
Reactome Name: Estrogen-dependent gene expression
See in Reactome
R-HSA-4086398
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-5578749
R-HSA-5578749
Reactome Name: Transcriptional regulation by small RNAs
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-426496
R-HSA-426496
Reactome Name: Post-transcriptional silencing by small RNAs
See in Reactome
R-HSA-5687128
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-195721
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-157118
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-8939211
R-HSA-162582
R-HSA-6807070
R-HSA-211000
R-HSA-1912422
R-HSA-1912422
Reactome Name: Pre-NOTCH Expression and Processing
See in Reactome
R-HSA-9024446
R-HSA-9024446
Reactome Name: NR1H2 and NR1H3-mediated signaling
See in Reactome
R-HSA-73857
|
Gene expression (Transcription)
Signal Transduction
|
R-HSA-1606561
(
R-HSA-1912408
)
R-HSA-1606561
Reaction Name: MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA
See in Reactome
R-HSA-1606682
(
R-HSA-1912408
)
R-HSA-1606682
Reaction Name: MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA
See in Reactome
R-HSA-1912362
(
R-HSA-1912408
)
R-HSA-1912362
Reaction Name: MIR150 microRNA binds 3'UTR of NOTCH3 mRNA
See in Reactome
R-HSA-1912363
(
R-HSA-1912408
)
R-HSA-1912363
Reaction Name: MIR200B/C microRNAs bind NOTCH1 mRNA
See in Reactome
R-HSA-1912364
(
R-HSA-1912408
)
R-HSA-1912364
Reaction Name: MIR181C microRNA binds 3'UTR of NOTCH4 mRNA
See in Reactome
R-HSA-1912366
(
R-HSA-1912408
)
R-HSA-1912366
Reaction Name: MIR206 microRNA binds 3'UTR of NOTCH3 mRNA
See in Reactome
R-HSA-1912367
(
R-HSA-1912408
)
R-HSA-1912367
Reaction Name: MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA
See in Reactome
R-HSA-1912368
(
R-HSA-1912408
)
R-HSA-1912368
Reaction Name: MIR302A microRNA binds 3'UTR of NOTCH4 mRNA
See in Reactome
R-HSA-1912406
(
R-HSA-1912408
)
R-HSA-1912406
Reaction Name: p53 positively regulates transcription of MIR34 microRNAs
See in Reactome
R-HSA-1912409
(
R-HSA-1912408
)
R-HSA-1912409
Reaction Name: NOTCH3 mRNA translation controlled by miRNAs
See in Reactome
R-HSA-1912410
(
R-HSA-1912408
)
R-HSA-1912410
Reaction Name: NOTCH4 mRNA translation controlled by miRNAs
See in Reactome
R-HSA-1912412
(
R-HSA-1912408
)
R-HSA-1912412
Reaction Name: NOTCH1 mRNA translation controlled by miRNAs
See in Reactome
R-HSA-1912413
(
R-HSA-1912408
)
R-HSA-1912413
Reaction Name: NOTCH2 mRNA translation controlled by miRNAs
See in Reactome
R-HSA-203862
(
R-HSA-203927
)
R-HSA-203862
Reaction Name: Dicer cleaves pre-miRNA to yield duplex miRNA
See in Reactome
R-HSA-2106614
(
R-HSA-203927
)
R-HSA-2106614
Reaction Name: Duplex miRNA is loaded into Argonaute
See in Reactome
R-HSA-2106615
(
R-HSA-426486
)
R-HSA-2106615
Reaction Name: Removal of siRNA passenger strand
See in Reactome
R-HSA-2106625
(
R-HSA-426486
)
R-HSA-2106625
Reaction Name: Duplex siRNA is loaded into Argonaute
See in Reactome
R-HSA-210805
(
R-HSA-203927
)
R-HSA-210805
Reaction Name: Removal of miRNA passenger strand
See in Reactome
R-HSA-2318752
(
R-HSA-5628897;
R-HSA-8943723
)
R-HSA-2318752
Reaction Name: miR-26A microRNAs bind PTEN mRNA
See in Reactome
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-426464
(
R-HSA-426486
)
R-HSA-426464
Reaction Name: Dicer cleaves double-stranded RNA to yield double-stranded siRNA
See in Reactome
R-HSA-426489
(
R-HSA-426496
)
R-HSA-426489
Reaction Name: RISC binds inexactly matching target RNAs
See in Reactome
R-HSA-426520
(
R-HSA-426496
)
R-HSA-426520
Reaction Name: Endonucleolytic RISC hydrolyzes target RNAs
See in Reactome
R-HSA-4518575
(
R-HSA-4086398
)
R-HSA-4518575
Reaction Name: miR-92b binds 3'UTR of NLK mRNA
See in Reactome
R-HSA-4518585
(
R-HSA-4086398
)
R-HSA-4518585
Reaction Name: NLK mRNA translation controlled by miR-92b
See in Reactome
R-HSA-5578712
(
R-HSA-5578749
)
R-HSA-5578742
(
R-HSA-5578749
)
R-HSA-5578742
Reaction Name: AGO1,2:small RNA complexes interact with chromatin
See in Reactome
R-HSA-5578744
(
R-HSA-5578749
)
R-HSA-5578744
Reaction Name: Importin-8 imports AGO2:miRNA into the nucleus
See in Reactome
R-HSA-5578965
(
R-HSA-5578749
)
R-HSA-5578966
(
R-HSA-5578749
)
R-HSA-5578966
Reaction Name: TNRC6A:AGO2:miRNA is transported into the nucleus
See in Reactome
R-HSA-5687103
(
R-HSA-5687128
)
R-HSA-5687103
Reaction Name: FOXO3 regulates MIR34B,C expression
See in Reactome
R-HSA-5687113
(
R-HSA-5687128
)
R-HSA-5687113
Reaction Name: MYC mRNA translation is negatively regulated by miR-34B and C
See in Reactome
R-HSA-8935785
(
R-HSA-8934593
)
R-HSA-8935785
Reaction Name: RUNX1 mRNA translation is inhibited by miR-17, miR-18a, miR-20a, miR-27a, miR-106a, miR-215, miR-302b, miR-378 and miR-675
See in Reactome
R-HSA-8935864
(
R-HSA-8934593
)
R-HSA-8935930
(
R-HSA-8934593
)
R-HSA-8936058
(
R-HSA-8934593
)
R-HSA-8936068
(
R-HSA-8934593
)
R-HSA-8936068
Reaction Name: H19 is cleaved to produce miR-675
See in Reactome
R-HSA-8939129
(
R-HSA-8934593
)
R-HSA-8944483
(
R-HSA-8943723
)
R-HSA-8944483
Reaction Name: miR-17 microRNA binds PTEN mRNA
See in Reactome
R-HSA-8944497
(
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8944522
(
R-HSA-8943723
)
R-HSA-8944522
Reaction Name: miR-19a microRNA binds PTEN mRNA
See in Reactome
R-HSA-8944538
(
R-HSA-8943723
)
R-HSA-8944538
Reaction Name: miR-22 microRNA binds PTEN mRNA
See in Reactome
R-HSA-8944569
(
R-HSA-8943723
)
R-HSA-8944569
Reaction Name: miR-25 microRNA binds PTEN mRNA
See in Reactome
R-HSA-8944599
(
R-HSA-8943723
)
R-HSA-8944599
Reaction Name: miR-93 microRNA binds PTEN mRNA
See in Reactome
R-HSA-8944632
(
R-HSA-8943723
)
R-HSA-8944632
Reaction Name: miR-106 microRNAs bind PTEN mRNA
See in Reactome
R-HSA-8944684
(
R-HSA-8943723
)
R-HSA-8944684
Reaction Name: miR-205 microRNA binds PTEN mRNA
See in Reactome
R-HSA-8945709
(
R-HSA-8943723
)
R-HSA-8945709
Reaction Name: miR-20 microRNAs bind PTEN mRNA
See in Reactome
R-HSA-8948524
(
R-HSA-8943723;
R-HSA-8948700
)
R-HSA-8948524
Reaction Name: PTENP1 mRNA binds miR-19b RISC
See in Reactome
R-HSA-8948536
(
R-HSA-8943723;
R-HSA-8948700
)
R-HSA-8948569
(
R-HSA-8943723
)
R-HSA-8948569
Reaction Name: miR-19b microRNA binds PTEN mRNA
See in Reactome
R-HSA-8948582
(
R-HSA-8943723;
R-HSA-8948700
)
R-HSA-8948582
Reaction Name: miR-17 microRNA binds VAPA mRNA
See in Reactome
R-HSA-8948583
(
R-HSA-8943723;
R-HSA-8948700
)
R-HSA-8948583
Reaction Name: miR-17 microRNA binds CNOT6L mRNA
See in Reactome
R-HSA-8948594
(
R-HSA-8943723;
R-HSA-8948700
)
R-HSA-8948594
Reaction Name: miR-19a microRNA binds VAPA mRNA
See in Reactome
R-HSA-8948602
(
R-HSA-8943723;
R-HSA-8948700
)
R-HSA-8948602
Reaction Name: miR-19a microRNA binds CNOT6L mRNA
See in Reactome
R-HSA-8948612
(
R-HSA-8943723;
R-HSA-8948700
)
R-HSA-8948612
Reaction Name: miR-19b microRNA binds CNOT6L mRNA
See in Reactome
R-HSA-8948621
(
R-HSA-8943723;
R-HSA-8948700
)
R-HSA-8948621
Reaction Name: miR-20 microRNAs bind VAPA mRNA
See in Reactome
R-HSA-8948623
(
R-HSA-8943723;
R-HSA-8948700
)
R-HSA-8948623
Reaction Name: miR-20 microRNAs bind CNOT6L mRNA
See in Reactome
R-HSA-8948641
(
R-HSA-8943723;
R-HSA-8948700
)
R-HSA-8948641
Reaction Name: miR-106 microRNAs bind VAPA mRNA
See in Reactome
R-HSA-8948651
(
R-HSA-8943723;
R-HSA-8948700
)
R-HSA-8948651
Reaction Name: miR-106a,(miR106b) microRNA binds CNOT6L mRNA
See in Reactome
R-HSA-9011958
(
R-HSA-9018519
)
R-HSA-9011958
Reaction Name: miR-26A and B bind to the 3'UTR of the GREB1 mRNA
See in Reactome
R-HSA-9011961
(
R-HSA-9018519
)
R-HSA-9011961
Reaction Name: GREB1 translation is negatively regulated by miR-26A and B
See in Reactome
R-HSA-9012186
(
R-HSA-9018519
)
R-HSA-9012186
Reaction Name: CHD1 translation is negatively regulated by miR-26A and B
See in Reactome
R-HSA-9012196
(
R-HSA-9018519
)
R-HSA-9012196
Reaction Name: KPNA2 translation is negatively regulated by miR-26A and B
See in Reactome
R-HSA-9012203
(
R-HSA-9018519
)
R-HSA-9012203
Reaction Name: miR-26A and B bind to the 3'UTR of the CHD11 mRNA
See in Reactome
R-HSA-9012208
(
R-HSA-9018519
)
R-HSA-9012208
Reaction Name: miR-26A and B bind to the 3'UTR of the KPNA2 mRNA
See in Reactome
R-HSA-9021182
(
R-HSA-8986944;
R-HSA-9022692
)
R-HSA-9021183
(
R-HSA-8986944;
R-HSA-9022692
)
R-HSA-9021183
Reaction Name: MECP2 mRNA translation is inhibited by miR-132
See in Reactome
R-HSA-9023909
(
R-HSA-426486
)
R-HSA-9023909
Reaction Name: C3PO hydrolyzes cleaved passenger strand
See in Reactome
R-HSA-9023912
(
R-HSA-426486
)
R-HSA-9023912
Reaction Name: AGO2 cleaves passenger strand of duplex siRNA
See in Reactome
R-HSA-9038545
(
R-HSA-9029569
)
R-HSA-9038545
Reaction Name: miR-613 binds to the 3'UTR of the NR1H3 mRNA
See in Reactome
R-HSA-9605052
(
R-HSA-9029569
)
R-HSA-9615501
(
R-HSA-8986944;
R-HSA-9022692
)
R-HSA-9615501
Reaction Name: MIR132 gene expression is stimulated by p-S133-CREB1
See in Reactome
R-HSA-9615554
(
R-HSA-8986944
)
R-HSA-9615554
Reaction Name: MIR137 gene expression is inhibited by MECP2 and SOX2
See in Reactome
R-HSA-9615570
(
R-HSA-8986944
)
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
R-HSA-9618392
(
R-HSA-9029569
)
R-HSA-9618392
Reaction Name: miR-26 binds to the 3'UTR of the ARL4C mRNA
See in Reactome
R-HSA-9618405
(
R-HSA-9029569
)
R-HSA-9618479
(
R-HSA-9029569
)
R-HSA-9618486
(
R-HSA-9029569
)
R-HSA-9618486
Reaction Name: miR-26 binds to the 3'UTR of the ABCA1 mRNA
See in Reactome
R-HSA-9624925
(
R-HSA-9029569
)
R-HSA-9624925
Reaction Name: miR-33 binds to the 3'UTR of the ABCA1 mRNA
See in Reactome
R-HSA-9657791
(
R-HSA-9029569
)
R-HSA-9657791
Reaction Name: miR-144 binds to the 3'UTR of the ABCA1 mRNA
See in Reactome
|
MONDO:0030913 |
RAC1 |
P63000 |
3.6.5.2
|
R-HSA-376172
R-HSA-445144
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-9619229
R-HSA-9619229
Reactome Name: Activation of RAC1 downstream of NMDARs
See in Reactome
R-HSA-428540
R-HSA-428543
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-399954
R-HSA-399954
Reactome Name: Sema3A PAK dependent Axon repulsion
See in Reactome
R-HSA-9032845
R-HSA-9032845
Reactome Name: Activated NTRK2 signals through CDK5
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-6798695
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-193648
R-HSA-193648
Reactome Name: NRAGE signals death through JNK
See in Reactome
R-HSA-5625900
R-HSA-5625740
R-HSA-9032759
R-HSA-1257604
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-389359
R-HSA-5627123
R-HSA-399955
R-HSA-399955
Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
See in Reactome
R-HSA-5626467
R-HSA-4420097
R-HSA-5663220
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5687128
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1433557
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-2424491
R-HSA-9013149
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-8875555
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-3928664
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-8848021
R-HSA-1280218
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9675108
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-112316
R-HSA-8875878
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-373760
R-HSA-9032500
R-HSA-9032500
Reactome Name: Activated NTRK2 signals through FYN
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-168249
R-HSA-195258
R-HSA-199991
R-HSA-73887
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-2682334
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-5653656
R-HSA-6806834
R-HSA-195721
R-HSA-2172127
R-HSA-204998
R-HSA-204998
Reactome Name: Cell death signalling via NRAGE, NRIF and NADE
See in Reactome
R-HSA-373755
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Developmental Biology
Neuronal System
Vesicle-mediated transport
Hemostasis
Signal Transduction
|
R-HSA-1011598
(
R-HSA-983231
)
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1433415
(
R-HSA-1433557
)
R-HSA-2029451
(
R-HSA-2029482
)
R-HSA-2029454
(
R-HSA-2029482
)
R-HSA-2029456
(
R-HSA-2029482;
R-HSA-5627123
)
R-HSA-2029465
(
R-HSA-2029482;
R-HSA-4420097;
R-HSA-5663213
)
R-HSA-2029465
Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)
See in Reactome
R-HSA-2029466
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029466
Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin
See in Reactome
R-HSA-2029467
(
R-HSA-2029482
)
R-HSA-2029467
Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO
See in Reactome
R-HSA-2029469
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029469
Reaction Name: p-ERK phosphorylates WAVEs and ABI
See in Reactome
R-HSA-205039
(
R-HSA-193648
)
R-HSA-205039
Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
See in Reactome
R-HSA-205136
(
R-HSA-193648
)
R-HSA-205136
Reaction Name: GTP-bound RAC contributes to JNK activation
See in Reactome
R-HSA-2130194
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2197690
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2316352
(
R-HSA-1445148
)
R-HSA-2316352
Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424476
(
R-HSA-2424491
)
R-HSA-2730840
(
R-HSA-2871796
)
R-HSA-2730856
(
R-HSA-2871796
)
R-HSA-2730889
(
R-HSA-2871796
)
R-HSA-2730889
Reaction Name: Recruitment of PAK to the membrane by binding active RAC1
See in Reactome
R-HSA-376123
(
R-HSA-376172
)
R-HSA-376123
Reaction Name: DSCAM associates with Rac1-GTP:pPAK1
See in Reactome
R-HSA-3858475
(
R-HSA-4086400
)
R-HSA-389348
(
R-HSA-389359
)
R-HSA-389788
(
R-HSA-389359;
R-HSA-5687128
)
R-HSA-389788
Reaction Name: Activation of PAKs by RAC1 and CDC42
See in Reactome
R-HSA-3928612
(
R-HSA-3928662
)
R-HSA-3928612
Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928619
(
R-HSA-3928662
)
R-HSA-3928620
(
R-HSA-3928662
)
R-HSA-3928625
(
R-HSA-3928664
)
R-HSA-3928628
(
R-HSA-3928665
)
R-HSA-3928628
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928633
(
R-HSA-3928664
)
R-HSA-3928633
Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it
See in Reactome
R-HSA-3928640
(
R-HSA-3928664
)
R-HSA-3928641
(
R-HSA-3928664
)
R-HSA-3928642
(
R-HSA-3928665
)
R-HSA-3928642
Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-399928
(
R-HSA-399955
)
R-HSA-399928
Reaction Name: Recruitment of Rnd1 to Plexin A
See in Reactome
R-HSA-399930
(
R-HSA-399954
)
R-HSA-399935
(
R-HSA-399955
)
R-HSA-399935
Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity
See in Reactome
R-HSA-399938
(
R-HSA-399955
)
R-HSA-399939
(
R-HSA-399954
)
R-HSA-399941
(
R-HSA-399955
)
R-HSA-399952
(
R-HSA-399954
)
R-HSA-399952
Reaction Name: Phosphorylation of LIMK-1 by PAK
See in Reactome
R-HSA-400682
(
R-HSA-416550
)
R-HSA-400682
Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D
See in Reactome
R-HSA-4093336
(
R-HSA-3928662
)
R-HSA-4093336
Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-428522
(
R-HSA-428543
)
R-HSA-428535
(
R-HSA-428540
)
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442592
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-442592
Reaction Name: WASPs or WAVEs activate the ARP2/3 complex
See in Reactome
R-HSA-445064
(
R-HSA-445144
)
R-HSA-445072
(
R-HSA-445144
)
R-HSA-445072
Reaction Name: Interaction of PAK1 with Rac1-GTP
See in Reactome
R-HSA-451347
(
R-HSA-376172
)
R-HSA-451366
(
R-HSA-376172
)
R-HSA-5218827
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218827
Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1
See in Reactome
R-HSA-5218839
(
R-HSA-4420097
)
R-HSA-5218839
Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1
See in Reactome
R-HSA-5218841
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218841
Reaction Name: NADPH oxidase 2 generates superoxide from oxygen
See in Reactome
R-HSA-5218850
(
R-HSA-4420097
)
R-HSA-5218850
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-5357445
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357472
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357483
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5626469
(
R-HSA-5626467
)
R-HSA-5626469
Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs
See in Reactome
R-HSA-5626507
(
R-HSA-5626467
)
R-HSA-5626507
Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin
See in Reactome
R-HSA-5626549
(
R-HSA-5626467
)
R-HSA-5627775
(
R-HSA-5627123;
R-HSA-5687128
)
R-HSA-5627775
Reaction Name: Autophosphorylation of PAK1,2,3
See in Reactome
R-HSA-5663232
(
R-HSA-5663220
)
R-HSA-5665659
(
R-HSA-5663220
)
R-HSA-5665659
Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin
See in Reactome
R-HSA-5665802
(
R-HSA-5663220
)
R-HSA-5665802
Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin
See in Reactome
R-HSA-5665809
(
R-HSA-5663220
)
R-HSA-5665809
Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments
See in Reactome
R-HSA-5668714
(
R-HSA-5668599
)
R-HSA-5668718
(
R-HSA-5668599
)
R-HSA-5668718
Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen
See in Reactome
R-HSA-5668731
(
R-HSA-5668599
)
R-HSA-5668731
Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen
See in Reactome
R-HSA-5668735
(
R-HSA-5668599
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5672304
(
R-HSA-5626467
)
R-HSA-5672304
Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1
See in Reactome
R-HSA-5672329
(
R-HSA-5626467
)
R-HSA-5672329
Reaction Name: IQGAP1 binds CLIP1 and microtubules
See in Reactome
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8848618
(
R-HSA-8849471
)
R-HSA-8848618
Reaction Name: Activation of RAC1 by the PXN:CRK complex
See in Reactome
R-HSA-8875591
(
R-HSA-8875555
)
R-HSA-8951586
(
R-HSA-4420097
)
R-HSA-8951586
Reaction Name: p-VAV family:PIP3 binds RAC1:GDP
See in Reactome
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981926
(
R-HSA-5627123
)
R-HSA-8981931
(
R-HSA-5627123
)
R-HSA-9013143
(
R-HSA-9013149
)
R-HSA-9013144
(
R-HSA-9013149
)
R-HSA-9013144
Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9013147
(
R-HSA-9013149
)
R-HSA-9013147
Reaction Name: RAC1 GDIs block activation of RAC1
See in Reactome
R-HSA-9032798
(
R-HSA-9032759
)
R-HSA-9033292
(
R-HSA-9032845
)
R-HSA-9033292
Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1
See in Reactome
R-HSA-9619803
(
R-HSA-9619229
)
R-HSA-9691168
(
R-HSA-9013149
)
R-HSA-9691168
Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane
See in Reactome
R-HSA-9691174
(
R-HSA-9013149
)
R-HSA-9691174
Reaction Name: RAC1 binds effectors at the ER membrane
See in Reactome
|
MONDO:0030924 |
PSMB10 |
P40306 |
3.4.25.1
|
R-HSA-8951664
R-HSA-4608870
R-HSA-4608870
Reactome Name: Asymmetric localization of PCP proteins
See in Reactome
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-8852276
R-HSA-8852276
Reactome Name: The role of GTSE1 in G2/M progression after G2 checkpoint
See in Reactome
R-HSA-8941858
R-HSA-8941858
Reactome Name: Regulation of RUNX3 expression and activity
See in Reactome
R-HSA-174184
R-HSA-174184
Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A
See in Reactome
R-HSA-69017
R-HSA-69017
Reactome Name: CDK-mediated phosphorylation and removal of Cdc6
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-187577
R-HSA-187577
Reactome Name: SCF(Skp2)-mediated degradation of p27/p21
See in Reactome
R-HSA-1236978
R-HSA-1236978
Reactome Name: Cross-presentation of soluble exogenous antigens (endosomes)
See in Reactome
R-HSA-5610780
R-HSA-5610780
Reactome Name: Degradation of GLI1 by the proteasome
See in Reactome
R-HSA-5610785
R-HSA-5610785
Reactome Name: GLI3 is processed to GLI3R by the proteasome
See in Reactome
R-HSA-8854050
R-HSA-8854050
Reactome Name: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
See in Reactome
R-HSA-69601
R-HSA-69601
Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
See in Reactome
R-HSA-1236974
R-HSA-5610783
R-HSA-5610783
Reactome Name: Degradation of GLI2 by the proteasome
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5668541
R-HSA-5668541
Reactome Name: TNFR2 non-canonical NF-kB pathway
See in Reactome
R-HSA-1169091
R-HSA-1169091
Reactome Name: Activation of NF-kappaB in B cells
See in Reactome
R-HSA-4641258
R-HSA-9010553
R-HSA-9010553
Reactome Name: Regulation of expression of SLITs and ROBOs
See in Reactome
R-HSA-202424
R-HSA-450408
R-HSA-450408
Reactome Name: AUF1 (hnRNP D0) binds and destabilizes mRNA
See in Reactome
R-HSA-5687128
R-HSA-5676590
R-HSA-5676590
Reactome Name: NIK-->noncanonical NF-kB signaling
See in Reactome
R-HSA-1234176
R-HSA-1234176
Reactome Name: Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
See in Reactome
R-HSA-211733
R-HSA-211733
Reactome Name: Regulation of activated PAK-2p34 by proteasome mediated degradation
See in Reactome
R-HSA-4641257
R-HSA-5607761
R-HSA-5607761
Reactome Name: Dectin-1 mediated noncanonical NF-kB signaling
See in Reactome
R-HSA-5358346
R-HSA-5607764
R-HSA-8939236
R-HSA-8939236
Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs
See in Reactome
R-HSA-174178
R-HSA-174178
Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
See in Reactome
R-HSA-8939902
R-HSA-8939902
Reactome Name: Regulation of RUNX2 expression and activity
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-68949
R-HSA-69481
R-HSA-5658442
R-HSA-174154
R-HSA-174154
Reactome Name: APC/C:Cdc20 mediated degradation of Securin
See in Reactome
R-HSA-195253
R-HSA-195253
Reactome Name: Degradation of beta-catenin by the destruction complex
See in Reactome
R-HSA-174084
R-HSA-174084
Reactome Name: Autodegradation of Cdh1 by Cdh1:APC/C
See in Reactome
R-HSA-174113
R-HSA-174113
Reactome Name: SCF-beta-TrCP mediated degradation of Emi1
See in Reactome
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
R-HSA-350562
R-HSA-350562
Reactome Name: Regulation of ornithine decarboxylase (ODC)
See in Reactome
R-HSA-5632684
R-HSA-5689603
R-HSA-75815
R-HSA-75815
Reactome Name: Ubiquitin-dependent degradation of Cyclin D
See in Reactome
R-HSA-9020702
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-376176
R-HSA-449147
R-HSA-8953897
R-HSA-5688426
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-9013694
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-5358351
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5684996
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-174143
R-HSA-174143
Reactome Name: APC/C-mediated degradation of cell cycle proteins
See in Reactome
R-HSA-69052
R-HSA-69052
Reactome Name: Switching of origins to a post-replicative state
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-4086400
R-HSA-212436
R-HSA-74160
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-1234174
R-HSA-69278
R-HSA-69541
R-HSA-382551
R-HSA-179419
R-HSA-179419
Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
See in Reactome
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-5673001
R-HSA-202403
R-HSA-69239
R-HSA-446652
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-176408
R-HSA-176408
Reactome Name: Regulation of APC/C activators between G1/S and early anaphase
See in Reactome
R-HSA-176409
R-HSA-176409
Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-169911
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-9675108
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-8953854
R-HSA-168249
R-HSA-453274
R-HSA-392499
R-HSA-453276
R-HSA-453276
Reactome Name: Regulation of mitotic cell cycle
See in Reactome
R-HSA-68886
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-176814
R-HSA-176814
Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-5610787
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-157118
R-HSA-351202
R-HSA-69275
R-HSA-195721
R-HSA-69242
R-HSA-1257604
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-109581
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-69615
R-HSA-69306
R-HSA-69610
R-HSA-69610
Reactome Name: p53-Independent DNA Damage Response
See in Reactome
R-HSA-69613
R-HSA-69613
Reactome Name: p53-Independent G1/S DNA damage checkpoint
See in Reactome
R-HSA-71291
R-HSA-71291
Reactome Name: Metabolism of amino acids and derivatives
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-422475
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-162582
R-HSA-68882
|
Cellular responses to stimuli
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Transport of small molecules
Metabolism of RNA
Metabolism of proteins
DNA Replication
Signal Transduction
|
R-HSA-1168640
(
R-HSA-1169091
)
R-HSA-1234159
(
R-HSA-1234176
)
R-HSA-1234159
Reaction Name: Proteasome proteolyzes ub-HIF-alpha
See in Reactome
R-HSA-1236935
(
R-HSA-1236974
)
R-HSA-1236935
Reaction Name: Proteasomal cleavage of substrate
See in Reactome
R-HSA-1236970
(
R-HSA-1236978
)
R-HSA-1236970
Reaction Name: Proteasomal clevage of exogenous antigen
See in Reactome
R-HSA-1504193
(
R-HSA-4641258
)
R-HSA-1504193
Reaction Name: Ubiquitinated DVL is degraded by the proteasome
See in Reactome
R-HSA-174058
(
R-HSA-174084
)
R-HSA-174058
Reaction Name: Degradation of multiubiquitinated Cdh1
See in Reactome
R-HSA-174105
(
R-HSA-174178
)
R-HSA-174105
Reaction Name: Degradation of multiubiquitinated cell cycle proteins
See in Reactome
R-HSA-174202
(
R-HSA-174154;
R-HSA-2467813
)
R-HSA-174202
Reaction Name: Degradation of multiubiquitinated Securin
See in Reactome
R-HSA-174203
(
R-HSA-174113
)
R-HSA-174203
Reaction Name: SCF-mediated degradation of Emi1
See in Reactome
R-HSA-174255
(
R-HSA-174184
)
R-HSA-174255
Reaction Name: Degradation multiubiquitinated Cyclin A
See in Reactome
R-HSA-187574
(
R-HSA-187577
)
R-HSA-187574
Reaction Name: Degradation of ubiquitinated p27/p21 by the 26S proteasome
See in Reactome
R-HSA-188191
(
R-HSA-174178
)
R-HSA-188191
Reaction Name: APC/C:Cdh1-mediated degradation of Skp2
See in Reactome
R-HSA-209061
(
R-HSA-9020702
)
R-HSA-209061
Reaction Name: Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex
See in Reactome
R-HSA-211715
(
R-HSA-211733
)
R-HSA-211715
Reaction Name: Proteasome mediated degradation of PAK-2p34
See in Reactome
R-HSA-2130282
(
R-HSA-195253
)
R-HSA-2130282
Reaction Name: Degradation of ubiquitinated beta catenin by the proteasome
See in Reactome
R-HSA-264458
(
R-HSA-349425
)
R-HSA-264458
Reaction Name: Proteasome mediated degradation of COP1
See in Reactome
R-HSA-353125
(
R-HSA-350562
)
R-HSA-353125
Reaction Name: 26S proteosome degrades ODC holoenzyme complex
See in Reactome
R-HSA-3640874
(
R-HSA-4641257
)
R-HSA-3640874
Reaction Name: Ub-RibC-AXIN is degraded by the proteasome
See in Reactome
R-HSA-450466
(
R-HSA-450408
)
R-HSA-4608855
(
R-HSA-4608870
)
R-HSA-4608855
Reaction Name: PRICKLE1 is degraded by the proteasome
See in Reactome
R-HSA-4641256
(
R-HSA-4641257
)
R-HSA-4641256
Reaction Name: Ubiquitinated AXIN is degraded by the proteasome
See in Reactome
R-HSA-4641260
(
R-HSA-4641258
)
R-HSA-4641260
Reaction Name: Ubiquitinated DVL1 is degraded by the proteasome
See in Reactome
R-HSA-5362448
(
R-HSA-5358346
)
R-HSA-5362448
Reaction Name: Hh C-terminal fragments are degraded by the proteasome
See in Reactome
R-HSA-5607724
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-5607724
Reaction Name: 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex
See in Reactome
R-HSA-5607731
(
R-HSA-5607761;
R-HSA-5607764;
R-HSA-5668541;
R-HSA-5676590
)
R-HSA-5607731
Reaction Name: 26S proteasome processes p-7S-p100:RELB to form p52:RELB
See in Reactome
R-HSA-5610754
(
R-HSA-5610785;
R-HSA-5610787
)
R-HSA-5610754
Reaction Name: GLI3 is partially degraded by the proteasome to yield the GLI3 repressor
See in Reactome
R-HSA-5610757
(
R-HSA-5610783;
R-HSA-5610787
)
R-HSA-5610757
Reaction Name: GLI2 is degraded by the proteasome
See in Reactome
R-HSA-5610758
(
R-HSA-5610780;
R-HSA-5610787
)
R-HSA-5610758
Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP
See in Reactome
R-HSA-5610760
(
R-HSA-5610780;
R-HSA-5610787
)
R-HSA-5610760
Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by ITCH
See in Reactome
R-HSA-5635854
(
R-HSA-5632684
)
R-HSA-5635854
Reaction Name: GLI2,3 are degraded by the proteasome
See in Reactome
R-HSA-5635868
(
R-HSA-5632684
)
R-HSA-5635868
Reaction Name: ub-GLI is degraded by the proteasome
See in Reactome
R-HSA-5658430
(
R-HSA-5658442
)
R-HSA-5658430
Reaction Name: NF1 is degraded by the proteasome
See in Reactome
R-HSA-5665854
(
R-HSA-5689603
)
R-HSA-5665854
Reaction Name: ADRM1:26S proteaseome binds UCHL5
See in Reactome
R-HSA-5665871
(
R-HSA-5689603
)
R-HSA-5668481
(
R-HSA-5668541
)
R-HSA-5668481
Reaction Name: Protesomal degradation of K48polyUb-TRAF3
See in Reactome
R-HSA-5668520
(
R-HSA-5668541
)
R-HSA-5668520
Reaction Name: 26Sproteasome degrades K48polyUb-NIK
See in Reactome
R-HSA-5687112
(
R-HSA-5687128
)
R-HSA-5687112
Reaction Name: MAPK6 is degraded by the 26S proteasome
See in Reactome
R-HSA-5689539
(
R-HSA-5689880
)
R-HSA-5689539
Reaction Name: ADRM1:26S proteaseome binds USP14
See in Reactome
R-HSA-68825
()
R-HSA-68825
Reaction Name: Ubiquitinated geminin is degraded by the proteasome
See in Reactome
R-HSA-68948
(
R-HSA-68949
)
R-HSA-68948
Reaction Name: Ubiquitinated Orc1 is degraded by the proteasome
See in Reactome
R-HSA-69016
(
R-HSA-69017
)
R-HSA-69016
Reaction Name: Ubiquitinated Cdc6 is degraded by the proteasome
See in Reactome
R-HSA-69600
(
R-HSA-69601
)
R-HSA-69600
Reaction Name: Proteolytic degradation of ubiquitinated-Cdc25A
See in Reactome
R-HSA-75825
(
R-HSA-75815
)
R-HSA-75825
Reaction Name: Proteasome mediated degradation of Cyclin D1
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8852354
(
R-HSA-69481;
R-HSA-8852276
)
R-HSA-8852354
Reaction Name: GTSE1 facilitates proteasome-mediated degradation of TP53
See in Reactome
R-HSA-8854044
(
R-HSA-8854050
)
R-HSA-8854044
Reaction Name: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
See in Reactome
R-HSA-8854071
(
R-HSA-8854050
)
R-HSA-8854071
Reaction Name: Proteasome-mediated degradation of PolyUb-FBXL7
See in Reactome
R-HSA-8866553
(
R-HSA-382556
)
R-HSA-8866553
Reaction Name: misfolded CFTR is degraded by the 26S proteasome
See in Reactome
R-HSA-8932355
(
R-HSA-8951664
)
R-HSA-8932355
Reaction Name: 26S proteasome degrades Ub-NFE2L2
See in Reactome
R-HSA-8939801
(
R-HSA-8939902
)
R-HSA-8939801
Reaction Name: 26S proteasome degrades PolyUb-RUNX2
See in Reactome
R-HSA-8952408
(
R-HSA-8941858
)
R-HSA-8952408
Reaction Name: Polyubiquitinated RUNX3 is degraded by the proteasome
See in Reactome
R-HSA-8956140
(
R-HSA-8951664
)
R-HSA-8956140
Reaction Name: NEDD8 and UBD bind NUB1 and the 26S proteasome
See in Reactome
R-HSA-8956184
(
R-HSA-8951664
)
R-HSA-8956184
Reaction Name: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
See in Reactome
R-HSA-8957265
(
R-HSA-8939236
)
R-HSA-8957265
Reaction Name: 26S proteasome degrades TP73 polyubiquitinated by ITCH
See in Reactome
R-HSA-9008110
(
R-HSA-8939902
)
R-HSA-9008110
Reaction Name: Proteasome degrades polyubiquitinated RUNX2
See in Reactome
R-HSA-9008475
(
R-HSA-8939902
)
R-HSA-9008475
Reaction Name: Proteasome degrades polyubiquitinated RUNX2
See in Reactome
R-HSA-9009362
(
R-HSA-8939902
)
R-HSA-9009362
Reaction Name: Proteasome degrades PolyUb-RUNX2
See in Reactome
R-HSA-9011313
(
R-HSA-9010553
)
R-HSA-9011313
Reaction Name: Proteasome degrades ubiquitinated ROBO3.1
See in Reactome
R-HSA-9604642
(
R-HSA-9604323
)
R-HSA-9604642
Reaction Name: Proteasome degrades ubiquitinated NICD4
See in Reactome
R-HSA-9755303
(
R-HSA-8951664
)
R-HSA-9755303
Reaction Name: 26S proteasome degrades HIFalpha
See in Reactome
R-HSA-9755306
(
R-HSA-8951664
)
R-HSA-9755306
Reaction Name: ub UBXN7 is degraded by the 26S proteasome
See in Reactome
R-HSA-9762096
()
R-HSA-9762096
Reaction Name: Ub,pS335,S338,T NFE2L2 is degraded
See in Reactome
R-HSA-983150
(
R-HSA-983168
)
R-HSA-983150
Reaction Name: Proteasomal cleavage of substrate
See in Reactome
|
MONDO:0032568 |
PAK1 |
Q13153 |
2.7.11.1
|
R-HSA-202433
R-HSA-202433
Reactome Name: Generation of second messenger molecules
See in Reactome
R-HSA-376172
R-HSA-428540
R-HSA-399954
R-HSA-399954
Reactome Name: Sema3A PAK dependent Axon repulsion
See in Reactome
R-HSA-5627123
R-HSA-9013424
R-HSA-5625740
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-389359
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5687128
R-HSA-9013423
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-9013149
R-HSA-9013148
R-HSA-5627117
R-HSA-3928664
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5621575
R-HSA-445144
R-HSA-9013420
R-HSA-9013409
R-HSA-9013406
R-HSA-9013407
R-HSA-9013404
R-HSA-445355
R-HSA-8964616
R-HSA-8964616
Reactome Name: G beta:gamma signalling through CDC42
See in Reactome
|
R-HSA-376176
R-HSA-9012999
R-HSA-397014
R-HSA-168256
R-HSA-194315
R-HSA-373760
R-HSA-1280218
R-HSA-1266738
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-194138
R-HSA-9675108
R-HSA-389356
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-202403
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-168249
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-2682334
R-HSA-195258
R-HSA-372790
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-373755
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-162582
R-HSA-373752
|
Muscle contraction
Immune System
Developmental Biology
Signal Transduction
|
R-HSA-2029454
(
R-HSA-2029482
)
R-HSA-2029456
(
R-HSA-2029482;
R-HSA-5627123
)
R-HSA-2029460
(
R-HSA-2029482;
R-HSA-5627123
)
R-HSA-2730856
(
R-HSA-2871796
)
R-HSA-2730887
(
R-HSA-2871796
)
R-HSA-2730887
Reaction Name: Autophosphorylation and activation of MEKK1
See in Reactome
R-HSA-2730889
(
R-HSA-2871796
)
R-HSA-2730889
Reaction Name: Recruitment of PAK to the membrane by binding active RAC1
See in Reactome
R-HSA-376123
(
R-HSA-376172
)
R-HSA-376123
Reaction Name: DSCAM associates with Rac1-GTP:pPAK1
See in Reactome
R-HSA-389788
(
R-HSA-389359;
R-HSA-5687128
)
R-HSA-389788
Reaction Name: Activation of PAKs by RAC1 and CDC42
See in Reactome
R-HSA-3928619
(
R-HSA-3928662
)
R-HSA-3928620
(
R-HSA-3928662
)
R-HSA-3928625
(
R-HSA-3928664
)
R-HSA-3928640
(
R-HSA-3928664
)
R-HSA-3928641
(
R-HSA-3928664
)
R-HSA-399930
(
R-HSA-399954
)
R-HSA-399939
(
R-HSA-399954
)
R-HSA-399952
(
R-HSA-399954
)
R-HSA-399952
Reaction Name: Phosphorylation of LIMK-1 by PAK
See in Reactome
R-HSA-419232
(
R-HSA-5625740;
R-HSA-5627117;
R-HSA-5627123
)
R-HSA-419232
Reaction Name: Myosin phosphatase dephosphorylates myosin regulatory light chain
See in Reactome
R-HSA-428531
(
R-HSA-428540
)
R-HSA-430183
(
R-HSA-202433
)
R-HSA-442832
(
R-HSA-5627123
)
R-HSA-445072
(
R-HSA-445144
)
R-HSA-445072
Reaction Name: Interaction of PAK1 with Rac1-GTP
See in Reactome
R-HSA-445797
(
R-HSA-445355;
R-HSA-5627123
)
R-HSA-445797
Reaction Name: MYLK (MLCK) Active Calmodulin Binding
See in Reactome
R-HSA-451347
(
R-HSA-376172
)
R-HSA-451366
(
R-HSA-376172
)
R-HSA-5357445
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357472
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357477
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357477
Reaction Name: PAK1-3 phosphorylates VE-cadherin
See in Reactome
R-HSA-5357483
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5627775
(
R-HSA-5627123;
R-HSA-5687128
)
R-HSA-5627775
Reaction Name: Autophosphorylation of PAK1,2,3
See in Reactome
R-HSA-5668947
(
R-HSA-5627123
)
R-HSA-5668947
Reaction Name: PAK1 phosphorylates myosin phosphatase
See in Reactome
R-HSA-5668984
(
R-HSA-5627123
)
R-HSA-5668984
Reaction Name: PAK1 or PAK2 phosphorylates MYLK
See in Reactome
R-HSA-5669158
(
R-HSA-5627123
)
R-HSA-5669240
(
R-HSA-5627123
)
R-HSA-5669250
(
R-HSA-5627123
)
R-HSA-5687086
(
R-HSA-5687128
)
R-HSA-5687086
Reaction Name: PAK1,2,3 phosphorylates MAPK6,4
See in Reactome
R-HSA-8964599
(
R-HSA-8964616
)
R-HSA-8964599
Reaction Name: Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex
See in Reactome
R-HSA-8964604
(
R-HSA-8964616
)
R-HSA-8964604
Reaction Name: CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated
See in Reactome
R-HSA-8964605
(
R-HSA-8964616
)
R-HSA-8964605
Reaction Name: PAK1:ARHGEF6 complex binds G-protein beta-gamma complex
See in Reactome
R-HSA-8964614
(
R-HSA-8964616
)
R-HSA-8964614
Reaction Name: PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated
See in Reactome
R-HSA-8964619
(
R-HSA-8964616
)
R-HSA-8964634
(
R-HSA-8964616
)
R-HSA-8964634
Reaction Name: CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9013157
(
R-HSA-9013148
)
R-HSA-9013157
Reaction Name: CDC42 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9017507
(
R-HSA-9013409
)
R-HSA-9017507
Reaction Name: RHOJ binds effectors at the plasma membrane
See in Reactome
R-HSA-9018746
(
R-HSA-9013406
)
R-HSA-9018746
Reaction Name: RHOQ binds effectors at the plasma membrane
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9018766
(
R-HSA-9013420
)
R-HSA-9018766
Reaction Name: RHOU binds effectors at the plasma membrane
See in Reactome
R-HSA-9018794
(
R-HSA-9013424
)
R-HSA-9018794
Reaction Name: RHOV binds effectors at the plasma membrane
See in Reactome
R-HSA-9018808
(
R-HSA-9013423
)
R-HSA-9018808
Reaction Name: RAC3 binds effectors at the plasma membrane
See in Reactome
|
MONDO:0054698 |
PSMB8 |
P28062 |
3.4.25.1
|
R-HSA-8951664
R-HSA-4608870
R-HSA-4608870
Reactome Name: Asymmetric localization of PCP proteins
See in Reactome
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-8852276
R-HSA-8852276
Reactome Name: The role of GTSE1 in G2/M progression after G2 checkpoint
See in Reactome
R-HSA-8941858
R-HSA-8941858
Reactome Name: Regulation of RUNX3 expression and activity
See in Reactome
R-HSA-174184
R-HSA-174184
Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A
See in Reactome
R-HSA-69017
R-HSA-69017
Reactome Name: CDK-mediated phosphorylation and removal of Cdc6
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-187577
R-HSA-187577
Reactome Name: SCF(Skp2)-mediated degradation of p27/p21
See in Reactome
R-HSA-1236978
R-HSA-1236978
Reactome Name: Cross-presentation of soluble exogenous antigens (endosomes)
See in Reactome
R-HSA-5610780
R-HSA-5610780
Reactome Name: Degradation of GLI1 by the proteasome
See in Reactome
R-HSA-5610785
R-HSA-5610785
Reactome Name: GLI3 is processed to GLI3R by the proteasome
See in Reactome
R-HSA-8854050
R-HSA-8854050
Reactome Name: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
See in Reactome
R-HSA-69601
R-HSA-69601
Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
See in Reactome
R-HSA-1236974
R-HSA-5610783
R-HSA-5610783
Reactome Name: Degradation of GLI2 by the proteasome
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5668541
R-HSA-5668541
Reactome Name: TNFR2 non-canonical NF-kB pathway
See in Reactome
R-HSA-1169091
R-HSA-1169091
Reactome Name: Activation of NF-kappaB in B cells
See in Reactome
R-HSA-4641258
R-HSA-9010553
R-HSA-9010553
Reactome Name: Regulation of expression of SLITs and ROBOs
See in Reactome
R-HSA-202424
R-HSA-450408
R-HSA-450408
Reactome Name: AUF1 (hnRNP D0) binds and destabilizes mRNA
See in Reactome
R-HSA-5687128
R-HSA-909733
R-HSA-909733
Reactome Name: Interferon alpha/beta signaling
See in Reactome
R-HSA-5676590
R-HSA-5676590
Reactome Name: NIK-->noncanonical NF-kB signaling
See in Reactome
R-HSA-1234176
R-HSA-1234176
Reactome Name: Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
See in Reactome
R-HSA-211733
R-HSA-211733
Reactome Name: Regulation of activated PAK-2p34 by proteasome mediated degradation
See in Reactome
R-HSA-4641257
R-HSA-5607761
R-HSA-5607761
Reactome Name: Dectin-1 mediated noncanonical NF-kB signaling
See in Reactome
R-HSA-5358346
R-HSA-5607764
R-HSA-8939236
R-HSA-8939236
Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs
See in Reactome
R-HSA-174178
R-HSA-174178
Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
See in Reactome
R-HSA-8939902
R-HSA-8939902
Reactome Name: Regulation of RUNX2 expression and activity
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-68949
R-HSA-69481
R-HSA-5658442
R-HSA-174154
R-HSA-174154
Reactome Name: APC/C:Cdc20 mediated degradation of Securin
See in Reactome
R-HSA-195253
R-HSA-195253
Reactome Name: Degradation of beta-catenin by the destruction complex
See in Reactome
R-HSA-174084
R-HSA-174084
Reactome Name: Autodegradation of Cdh1 by Cdh1:APC/C
See in Reactome
R-HSA-174113
R-HSA-174113
Reactome Name: SCF-beta-TrCP mediated degradation of Emi1
See in Reactome
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
R-HSA-350562
R-HSA-350562
Reactome Name: Regulation of ornithine decarboxylase (ODC)
See in Reactome
R-HSA-5632684
R-HSA-5689603
R-HSA-75815
R-HSA-75815
Reactome Name: Ubiquitin-dependent degradation of Cyclin D
See in Reactome
R-HSA-9020702
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-376176
R-HSA-449147
R-HSA-8953897
R-HSA-5688426
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-9013694
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-5358351
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5684996
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-174143
R-HSA-174143
Reactome Name: APC/C-mediated degradation of cell cycle proteins
See in Reactome
R-HSA-69052
R-HSA-69052
Reactome Name: Switching of origins to a post-replicative state
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-4086400
R-HSA-212436
R-HSA-74160
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-1234174
R-HSA-69278
R-HSA-69541
R-HSA-382551
R-HSA-179419
R-HSA-179419
Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
See in Reactome
R-HSA-913531
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-5673001
R-HSA-202403
R-HSA-69239
R-HSA-446652
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-176408
R-HSA-176408
Reactome Name: Regulation of APC/C activators between G1/S and early anaphase
See in Reactome
R-HSA-176409
R-HSA-176409
Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-169911
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-9675108
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-8953854
R-HSA-168249
R-HSA-453274
R-HSA-392499
R-HSA-453276
R-HSA-453276
Reactome Name: Regulation of mitotic cell cycle
See in Reactome
R-HSA-68886
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-176814
R-HSA-176814
Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-5610787
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-157118
R-HSA-351202
R-HSA-69275
R-HSA-195721
R-HSA-69242
R-HSA-1257604
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-109581
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-69615
R-HSA-69306
R-HSA-69610
R-HSA-69610
Reactome Name: p53-Independent DNA Damage Response
See in Reactome
R-HSA-69613
R-HSA-69613
Reactome Name: p53-Independent G1/S DNA damage checkpoint
See in Reactome
R-HSA-71291
R-HSA-71291
Reactome Name: Metabolism of amino acids and derivatives
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-422475
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-162582
R-HSA-68882
|
Cellular responses to stimuli
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Transport of small molecules
Metabolism of RNA
Metabolism of proteins
DNA Replication
Signal Transduction
|
R-HSA-1015702
(
R-HSA-909733
)
R-HSA-1015702
Reaction Name: Expression of IFN-induced genes
See in Reactome
R-HSA-1168640
(
R-HSA-1169091
)
R-HSA-1234159
(
R-HSA-1234176
)
R-HSA-1234159
Reaction Name: Proteasome proteolyzes ub-HIF-alpha
See in Reactome
R-HSA-1236935
(
R-HSA-1236974
)
R-HSA-1236935
Reaction Name: Proteasomal cleavage of substrate
See in Reactome
R-HSA-1236970
(
R-HSA-1236978
)
R-HSA-1236970
Reaction Name: Proteasomal clevage of exogenous antigen
See in Reactome
R-HSA-1504193
(
R-HSA-4641258
)
R-HSA-1504193
Reaction Name: Ubiquitinated DVL is degraded by the proteasome
See in Reactome
R-HSA-174058
(
R-HSA-174084
)
R-HSA-174058
Reaction Name: Degradation of multiubiquitinated Cdh1
See in Reactome
R-HSA-174105
(
R-HSA-174178
)
R-HSA-174105
Reaction Name: Degradation of multiubiquitinated cell cycle proteins
See in Reactome
R-HSA-174202
(
R-HSA-174154;
R-HSA-2467813
)
R-HSA-174202
Reaction Name: Degradation of multiubiquitinated Securin
See in Reactome
R-HSA-174203
(
R-HSA-174113
)
R-HSA-174203
Reaction Name: SCF-mediated degradation of Emi1
See in Reactome
R-HSA-174255
(
R-HSA-174184
)
R-HSA-174255
Reaction Name: Degradation multiubiquitinated Cyclin A
See in Reactome
R-HSA-187574
(
R-HSA-187577
)
R-HSA-187574
Reaction Name: Degradation of ubiquitinated p27/p21 by the 26S proteasome
See in Reactome
R-HSA-188191
(
R-HSA-174178
)
R-HSA-188191
Reaction Name: APC/C:Cdh1-mediated degradation of Skp2
See in Reactome
R-HSA-209061
(
R-HSA-9020702
)
R-HSA-209061
Reaction Name: Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex
See in Reactome
R-HSA-211715
(
R-HSA-211733
)
R-HSA-211715
Reaction Name: Proteasome mediated degradation of PAK-2p34
See in Reactome
R-HSA-2130282
(
R-HSA-195253
)
R-HSA-2130282
Reaction Name: Degradation of ubiquitinated beta catenin by the proteasome
See in Reactome
R-HSA-264458
(
R-HSA-349425
)
R-HSA-264458
Reaction Name: Proteasome mediated degradation of COP1
See in Reactome
R-HSA-353125
(
R-HSA-350562
)
R-HSA-353125
Reaction Name: 26S proteosome degrades ODC holoenzyme complex
See in Reactome
R-HSA-3640874
(
R-HSA-4641257
)
R-HSA-3640874
Reaction Name: Ub-RibC-AXIN is degraded by the proteasome
See in Reactome
R-HSA-450466
(
R-HSA-450408
)
R-HSA-4608855
(
R-HSA-4608870
)
R-HSA-4608855
Reaction Name: PRICKLE1 is degraded by the proteasome
See in Reactome
R-HSA-4641256
(
R-HSA-4641257
)
R-HSA-4641256
Reaction Name: Ubiquitinated AXIN is degraded by the proteasome
See in Reactome
R-HSA-4641260
(
R-HSA-4641258
)
R-HSA-4641260
Reaction Name: Ubiquitinated DVL1 is degraded by the proteasome
See in Reactome
R-HSA-5362448
(
R-HSA-5358346
)
R-HSA-5362448
Reaction Name: Hh C-terminal fragments are degraded by the proteasome
See in Reactome
R-HSA-5607724
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-5607724
Reaction Name: 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex
See in Reactome
R-HSA-5607731
(
R-HSA-5607761;
R-HSA-5607764;
R-HSA-5668541;
R-HSA-5676590
)
R-HSA-5607731
Reaction Name: 26S proteasome processes p-7S-p100:RELB to form p52:RELB
See in Reactome
R-HSA-5610754
(
R-HSA-5610785;
R-HSA-5610787
)
R-HSA-5610754
Reaction Name: GLI3 is partially degraded by the proteasome to yield the GLI3 repressor
See in Reactome
R-HSA-5610757
(
R-HSA-5610783;
R-HSA-5610787
)
R-HSA-5610757
Reaction Name: GLI2 is degraded by the proteasome
See in Reactome
R-HSA-5610758
(
R-HSA-5610780;
R-HSA-5610787
)
R-HSA-5610758
Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP
See in Reactome
R-HSA-5610760
(
R-HSA-5610780;
R-HSA-5610787
)
R-HSA-5610760
Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by ITCH
See in Reactome
R-HSA-5635854
(
R-HSA-5632684
)
R-HSA-5635854
Reaction Name: GLI2,3 are degraded by the proteasome
See in Reactome
R-HSA-5635868
(
R-HSA-5632684
)
R-HSA-5635868
Reaction Name: ub-GLI is degraded by the proteasome
See in Reactome
R-HSA-5658430
(
R-HSA-5658442
)
R-HSA-5658430
Reaction Name: NF1 is degraded by the proteasome
See in Reactome
R-HSA-5665854
(
R-HSA-5689603
)
R-HSA-5665854
Reaction Name: ADRM1:26S proteaseome binds UCHL5
See in Reactome
R-HSA-5665871
(
R-HSA-5689603
)
R-HSA-5668481
(
R-HSA-5668541
)
R-HSA-5668481
Reaction Name: Protesomal degradation of K48polyUb-TRAF3
See in Reactome
R-HSA-5668520
(
R-HSA-5668541
)
R-HSA-5668520
Reaction Name: 26Sproteasome degrades K48polyUb-NIK
See in Reactome
R-HSA-5687112
(
R-HSA-5687128
)
R-HSA-5687112
Reaction Name: MAPK6 is degraded by the 26S proteasome
See in Reactome
R-HSA-5689539
(
R-HSA-5689880
)
R-HSA-5689539
Reaction Name: ADRM1:26S proteaseome binds USP14
See in Reactome
R-HSA-68825
()
R-HSA-68825
Reaction Name: Ubiquitinated geminin is degraded by the proteasome
See in Reactome
R-HSA-68948
(
R-HSA-68949
)
R-HSA-68948
Reaction Name: Ubiquitinated Orc1 is degraded by the proteasome
See in Reactome
R-HSA-69016
(
R-HSA-69017
)
R-HSA-69016
Reaction Name: Ubiquitinated Cdc6 is degraded by the proteasome
See in Reactome
R-HSA-69600
(
R-HSA-69601
)
R-HSA-69600
Reaction Name: Proteolytic degradation of ubiquitinated-Cdc25A
See in Reactome
R-HSA-75825
(
R-HSA-75815
)
R-HSA-75825
Reaction Name: Proteasome mediated degradation of Cyclin D1
See in Reactome
R-HSA-8850992
(
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8852354
(
R-HSA-69481;
R-HSA-8852276
)
R-HSA-8852354
Reaction Name: GTSE1 facilitates proteasome-mediated degradation of TP53
See in Reactome
R-HSA-8854044
(
R-HSA-8854050
)
R-HSA-8854044
Reaction Name: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
See in Reactome
R-HSA-8854071
(
R-HSA-8854050
)
R-HSA-8854071
Reaction Name: Proteasome-mediated degradation of PolyUb-FBXL7
See in Reactome
R-HSA-8866553
(
R-HSA-382556
)
R-HSA-8866553
Reaction Name: misfolded CFTR is degraded by the 26S proteasome
See in Reactome
R-HSA-8932355
(
R-HSA-8951664
)
R-HSA-8932355
Reaction Name: 26S proteasome degrades Ub-NFE2L2
See in Reactome
R-HSA-8939801
(
R-HSA-8939902
)
R-HSA-8939801
Reaction Name: 26S proteasome degrades PolyUb-RUNX2
See in Reactome
R-HSA-8952408
(
R-HSA-8941858
)
R-HSA-8952408
Reaction Name: Polyubiquitinated RUNX3 is degraded by the proteasome
See in Reactome
R-HSA-8956140
(
R-HSA-8951664
)
R-HSA-8956140
Reaction Name: NEDD8 and UBD bind NUB1 and the 26S proteasome
See in Reactome
R-HSA-8956184
(
R-HSA-8951664
)
R-HSA-8956184
Reaction Name: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
See in Reactome
R-HSA-8957265
(
R-HSA-8939236
)
R-HSA-8957265
Reaction Name: 26S proteasome degrades TP73 polyubiquitinated by ITCH
See in Reactome
R-HSA-9008110
(
R-HSA-8939902
)
R-HSA-9008110
Reaction Name: Proteasome degrades polyubiquitinated RUNX2
See in Reactome
R-HSA-9008475
(
R-HSA-8939902
)
R-HSA-9008475
Reaction Name: Proteasome degrades polyubiquitinated RUNX2
See in Reactome
R-HSA-9009362
(
R-HSA-8939902
)
R-HSA-9009362
Reaction Name: Proteasome degrades PolyUb-RUNX2
See in Reactome
R-HSA-9011313
(
R-HSA-9010553
)
R-HSA-9011313
Reaction Name: Proteasome degrades ubiquitinated ROBO3.1
See in Reactome
R-HSA-9604642
(
R-HSA-9604323
)
R-HSA-9604642
Reaction Name: Proteasome degrades ubiquitinated NICD4
See in Reactome
R-HSA-9755303
(
R-HSA-8951664
)
R-HSA-9755303
Reaction Name: 26S proteasome degrades HIFalpha
See in Reactome
R-HSA-9755306
(
R-HSA-8951664
)
R-HSA-9755306
Reaction Name: ub UBXN7 is degraded by the 26S proteasome
See in Reactome
R-HSA-9762096
()
R-HSA-9762096
Reaction Name: Ub,pS335,S338,T NFE2L2 is degraded
See in Reactome
R-HSA-983150
(
R-HSA-983168
)
R-HSA-983150
Reaction Name: Proteasomal cleavage of substrate
See in Reactome
|
MONDO:0054699 |
PSMB9 |
P28065 |
3.4.25.1
|
R-HSA-8951664
R-HSA-4608870
R-HSA-4608870
Reactome Name: Asymmetric localization of PCP proteins
See in Reactome
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-8852276
R-HSA-8852276
Reactome Name: The role of GTSE1 in G2/M progression after G2 checkpoint
See in Reactome
R-HSA-8941858
R-HSA-8941858
Reactome Name: Regulation of RUNX3 expression and activity
See in Reactome
R-HSA-174184
R-HSA-174184
Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A
See in Reactome
R-HSA-69017
R-HSA-69017
Reactome Name: CDK-mediated phosphorylation and removal of Cdc6
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-187577
R-HSA-187577
Reactome Name: SCF(Skp2)-mediated degradation of p27/p21
See in Reactome
R-HSA-1236978
R-HSA-1236978
Reactome Name: Cross-presentation of soluble exogenous antigens (endosomes)
See in Reactome
R-HSA-5610780
R-HSA-5610780
Reactome Name: Degradation of GLI1 by the proteasome
See in Reactome
R-HSA-5610785
R-HSA-5610785
Reactome Name: GLI3 is processed to GLI3R by the proteasome
See in Reactome
R-HSA-8854050
R-HSA-8854050
Reactome Name: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
See in Reactome
R-HSA-69601
R-HSA-69601
Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
See in Reactome
R-HSA-1236974
R-HSA-5610783
R-HSA-5610783
Reactome Name: Degradation of GLI2 by the proteasome
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5668541
R-HSA-5668541
Reactome Name: TNFR2 non-canonical NF-kB pathway
See in Reactome
R-HSA-1169091
R-HSA-1169091
Reactome Name: Activation of NF-kappaB in B cells
See in Reactome
R-HSA-4641258
R-HSA-9010553
R-HSA-9010553
Reactome Name: Regulation of expression of SLITs and ROBOs
See in Reactome
R-HSA-202424
R-HSA-450408
R-HSA-450408
Reactome Name: AUF1 (hnRNP D0) binds and destabilizes mRNA
See in Reactome
R-HSA-5687128
R-HSA-5676590
R-HSA-5676590
Reactome Name: NIK-->noncanonical NF-kB signaling
See in Reactome
R-HSA-1234176
R-HSA-1234176
Reactome Name: Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
See in Reactome
R-HSA-211733
R-HSA-211733
Reactome Name: Regulation of activated PAK-2p34 by proteasome mediated degradation
See in Reactome
R-HSA-4641257
R-HSA-5607761
R-HSA-5607761
Reactome Name: Dectin-1 mediated noncanonical NF-kB signaling
See in Reactome
R-HSA-5358346
R-HSA-5607764
R-HSA-8939236
R-HSA-8939236
Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs
See in Reactome
R-HSA-174178
R-HSA-174178
Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
See in Reactome
R-HSA-8939902
R-HSA-8939902
Reactome Name: Regulation of RUNX2 expression and activity
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-68949
R-HSA-69481
R-HSA-5658442
R-HSA-174154
R-HSA-174154
Reactome Name: APC/C:Cdc20 mediated degradation of Securin
See in Reactome
R-HSA-195253
R-HSA-195253
Reactome Name: Degradation of beta-catenin by the destruction complex
See in Reactome
R-HSA-174084
R-HSA-174084
Reactome Name: Autodegradation of Cdh1 by Cdh1:APC/C
See in Reactome
R-HSA-174113
R-HSA-174113
Reactome Name: SCF-beta-TrCP mediated degradation of Emi1
See in Reactome
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
R-HSA-350562
R-HSA-350562
Reactome Name: Regulation of ornithine decarboxylase (ODC)
See in Reactome
R-HSA-5632684
R-HSA-5689603
R-HSA-75815
R-HSA-75815
Reactome Name: Ubiquitin-dependent degradation of Cyclin D
See in Reactome
R-HSA-9020702
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-376176
R-HSA-449147
R-HSA-8953897
R-HSA-5688426
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-9013694
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-5358351
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5684996
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-174143
R-HSA-174143
Reactome Name: APC/C-mediated degradation of cell cycle proteins
See in Reactome
R-HSA-69052
R-HSA-69052
Reactome Name: Switching of origins to a post-replicative state
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-4086400
R-HSA-212436
R-HSA-74160
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-1234174
R-HSA-69278
R-HSA-69541
R-HSA-382551
R-HSA-179419
R-HSA-179419
Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
See in Reactome
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-5673001
R-HSA-202403
R-HSA-69239
R-HSA-446652
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-176408
R-HSA-176408
Reactome Name: Regulation of APC/C activators between G1/S and early anaphase
See in Reactome
R-HSA-176409
R-HSA-176409
Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-169911
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-9675108
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-8953854
R-HSA-168249
R-HSA-453274
R-HSA-392499
R-HSA-453276
R-HSA-453276
Reactome Name: Regulation of mitotic cell cycle
See in Reactome
R-HSA-68886
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-176814
R-HSA-176814
Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-5610787
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-157118
R-HSA-351202
R-HSA-69275
R-HSA-195721
R-HSA-69242
R-HSA-1257604
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-109581
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-69615
R-HSA-69306
R-HSA-69610
R-HSA-69610
Reactome Name: p53-Independent DNA Damage Response
See in Reactome
R-HSA-69613
R-HSA-69613
Reactome Name: p53-Independent G1/S DNA damage checkpoint
See in Reactome
R-HSA-71291
R-HSA-71291
Reactome Name: Metabolism of amino acids and derivatives
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-422475
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-162582
R-HSA-68882
|
Cellular responses to stimuli
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Transport of small molecules
Metabolism of RNA
Metabolism of proteins
DNA Replication
Signal Transduction
|
R-HSA-1168640
(
R-HSA-1169091
)
R-HSA-1234159
(
R-HSA-1234176
)
R-HSA-1234159
Reaction Name: Proteasome proteolyzes ub-HIF-alpha
See in Reactome
R-HSA-1236935
(
R-HSA-1236974
)
R-HSA-1236935
Reaction Name: Proteasomal cleavage of substrate
See in Reactome
R-HSA-1236970
(
R-HSA-1236978
)
R-HSA-1236970
Reaction Name: Proteasomal clevage of exogenous antigen
See in Reactome
R-HSA-1504193
(
R-HSA-4641258
)
R-HSA-1504193
Reaction Name: Ubiquitinated DVL is degraded by the proteasome
See in Reactome
R-HSA-174058
(
R-HSA-174084
)
R-HSA-174058
Reaction Name: Degradation of multiubiquitinated Cdh1
See in Reactome
R-HSA-174105
(
R-HSA-174178
)
R-HSA-174105
Reaction Name: Degradation of multiubiquitinated cell cycle proteins
See in Reactome
R-HSA-174202
(
R-HSA-174154;
R-HSA-2467813
)
R-HSA-174202
Reaction Name: Degradation of multiubiquitinated Securin
See in Reactome
R-HSA-174203
(
R-HSA-174113
)
R-HSA-174203
Reaction Name: SCF-mediated degradation of Emi1
See in Reactome
R-HSA-174255
(
R-HSA-174184
)
R-HSA-174255
Reaction Name: Degradation multiubiquitinated Cyclin A
See in Reactome
R-HSA-187574
(
R-HSA-187577
)
R-HSA-187574
Reaction Name: Degradation of ubiquitinated p27/p21 by the 26S proteasome
See in Reactome
R-HSA-188191
(
R-HSA-174178
)
R-HSA-188191
Reaction Name: APC/C:Cdh1-mediated degradation of Skp2
See in Reactome
R-HSA-209061
(
R-HSA-9020702
)
R-HSA-209061
Reaction Name: Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex
See in Reactome
R-HSA-211715
(
R-HSA-211733
)
R-HSA-211715
Reaction Name: Proteasome mediated degradation of PAK-2p34
See in Reactome
R-HSA-2130282
(
R-HSA-195253
)
R-HSA-2130282
Reaction Name: Degradation of ubiquitinated beta catenin by the proteasome
See in Reactome
R-HSA-264458
(
R-HSA-349425
)
R-HSA-264458
Reaction Name: Proteasome mediated degradation of COP1
See in Reactome
R-HSA-353125
(
R-HSA-350562
)
R-HSA-353125
Reaction Name: 26S proteosome degrades ODC holoenzyme complex
See in Reactome
R-HSA-3640874
(
R-HSA-4641257
)
R-HSA-3640874
Reaction Name: Ub-RibC-AXIN is degraded by the proteasome
See in Reactome
R-HSA-450466
(
R-HSA-450408
)
R-HSA-4608855
(
R-HSA-4086400;
R-HSA-4608870
)
R-HSA-4608855
Reaction Name: PRICKLE1 is degraded by the proteasome
See in Reactome
R-HSA-4641256
(
R-HSA-4641257
)
R-HSA-4641256
Reaction Name: Ubiquitinated AXIN is degraded by the proteasome
See in Reactome
R-HSA-4641260
(
R-HSA-4641258
)
R-HSA-4641260
Reaction Name: Ubiquitinated DVL1 is degraded by the proteasome
See in Reactome
R-HSA-5362448
(
R-HSA-5358346
)
R-HSA-5362448
Reaction Name: Hh C-terminal fragments are degraded by the proteasome
See in Reactome
R-HSA-5607724
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-5607724
Reaction Name: 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex
See in Reactome
R-HSA-5607731
(
R-HSA-5607761;
R-HSA-5607764;
R-HSA-5668541;
R-HSA-5676590
)
R-HSA-5607731
Reaction Name: 26S proteasome processes p-7S-p100:RELB to form p52:RELB
See in Reactome
R-HSA-5610754
(
R-HSA-5610785;
R-HSA-5610787
)
R-HSA-5610754
Reaction Name: GLI3 is partially degraded by the proteasome to yield the GLI3 repressor
See in Reactome
R-HSA-5610757
(
R-HSA-5610783;
R-HSA-5610787
)
R-HSA-5610757
Reaction Name: GLI2 is degraded by the proteasome
See in Reactome
R-HSA-5610758
(
R-HSA-5610780;
R-HSA-5610787
)
R-HSA-5610758
Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP
See in Reactome
R-HSA-5610760
(
R-HSA-5610780;
R-HSA-5610787
)
R-HSA-5610760
Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by ITCH
See in Reactome
R-HSA-5635854
(
R-HSA-5632684
)
R-HSA-5635854
Reaction Name: GLI2,3 are degraded by the proteasome
See in Reactome
R-HSA-5635868
(
R-HSA-5632684
)
R-HSA-5635868
Reaction Name: ub-GLI is degraded by the proteasome
See in Reactome
R-HSA-5658430
(
R-HSA-5658442
)
R-HSA-5658430
Reaction Name: NF1 is degraded by the proteasome
See in Reactome
R-HSA-5665854
(
R-HSA-5689603
)
R-HSA-5665854
Reaction Name: ADRM1:26S proteaseome binds UCHL5
See in Reactome
R-HSA-5665871
(
R-HSA-5689603
)
R-HSA-5668481
(
R-HSA-5668541
)
R-HSA-5668481
Reaction Name: Protesomal degradation of K48polyUb-TRAF3
See in Reactome
R-HSA-5668520
(
R-HSA-5668541
)
R-HSA-5668520
Reaction Name: 26Sproteasome degrades K48polyUb-NIK
See in Reactome
R-HSA-5687112
(
R-HSA-5687128
)
R-HSA-5687112
Reaction Name: MAPK6 is degraded by the 26S proteasome
See in Reactome
R-HSA-5689539
(
R-HSA-5689880
)
R-HSA-5689539
Reaction Name: ADRM1:26S proteaseome binds USP14
See in Reactome
R-HSA-68825
()
R-HSA-68825
Reaction Name: Ubiquitinated geminin is degraded by the proteasome
See in Reactome
R-HSA-68948
(
R-HSA-68949
)
R-HSA-68948
Reaction Name: Ubiquitinated Orc1 is degraded by the proteasome
See in Reactome
R-HSA-69016
(
R-HSA-69017
)
R-HSA-69016
Reaction Name: Ubiquitinated Cdc6 is degraded by the proteasome
See in Reactome
R-HSA-69600
(
R-HSA-69601
)
R-HSA-69600
Reaction Name: Proteolytic degradation of ubiquitinated-Cdc25A
See in Reactome
R-HSA-75825
(
R-HSA-75815
)
R-HSA-75825
Reaction Name: Proteasome mediated degradation of Cyclin D1
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8852354
(
R-HSA-69481;
R-HSA-8852276
)
R-HSA-8852354
Reaction Name: GTSE1 facilitates proteasome-mediated degradation of TP53
See in Reactome
R-HSA-8854044
(
R-HSA-8854050
)
R-HSA-8854044
Reaction Name: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
See in Reactome
R-HSA-8854071
(
R-HSA-8854050
)
R-HSA-8854071
Reaction Name: Proteasome-mediated degradation of PolyUb-FBXL7
See in Reactome
R-HSA-8866553
(
R-HSA-382556
)
R-HSA-8866553
Reaction Name: misfolded CFTR is degraded by the 26S proteasome
See in Reactome
R-HSA-8932355
(
R-HSA-8951664
)
R-HSA-8932355
Reaction Name: 26S proteasome degrades Ub-NFE2L2
See in Reactome
R-HSA-8939801
(
R-HSA-8939902
)
R-HSA-8939801
Reaction Name: 26S proteasome degrades PolyUb-RUNX2
See in Reactome
R-HSA-8952408
(
R-HSA-8941858
)
R-HSA-8952408
Reaction Name: Polyubiquitinated RUNX3 is degraded by the proteasome
See in Reactome
R-HSA-8956140
(
R-HSA-8951664
)
R-HSA-8956140
Reaction Name: NEDD8 and UBD bind NUB1 and the 26S proteasome
See in Reactome
R-HSA-8956184
(
R-HSA-8951664
)
R-HSA-8956184
Reaction Name: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
See in Reactome
R-HSA-8957265
(
R-HSA-8939236
)
R-HSA-8957265
Reaction Name: 26S proteasome degrades TP73 polyubiquitinated by ITCH
See in Reactome
R-HSA-9008110
(
R-HSA-8939902
)
R-HSA-9008110
Reaction Name: Proteasome degrades polyubiquitinated RUNX2
See in Reactome
R-HSA-9008475
(
R-HSA-8939902
)
R-HSA-9008475
Reaction Name: Proteasome degrades polyubiquitinated RUNX2
See in Reactome
R-HSA-9009362
(
R-HSA-8939902
)
R-HSA-9009362
Reaction Name: Proteasome degrades PolyUb-RUNX2
See in Reactome
R-HSA-9011313
(
R-HSA-9010553
)
R-HSA-9011313
Reaction Name: Proteasome degrades ubiquitinated ROBO3.1
See in Reactome
R-HSA-9604642
(
R-HSA-9604323
)
R-HSA-9604642
Reaction Name: Proteasome degrades ubiquitinated NICD4
See in Reactome
R-HSA-9755303
(
R-HSA-8951664
)
R-HSA-9755303
Reaction Name: 26S proteasome degrades HIFalpha
See in Reactome
R-HSA-9755306
(
R-HSA-8951664
)
R-HSA-9755306
Reaction Name: ub UBXN7 is degraded by the 26S proteasome
See in Reactome
R-HSA-9762096
()
R-HSA-9762096
Reaction Name: Ub,pS335,S338,T NFE2L2 is degraded
See in Reactome
R-HSA-983150
(
R-HSA-983168
)
R-HSA-983150
Reaction Name: Proteasomal cleavage of substrate
See in Reactome
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