DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-5684264)

Number of enzymes:	4
Number of disease:	7
Number of reactomes:	30
Number of reactions:	65

Search results (Reactome ID: R-HSA-5684264)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007970	MAP2K1	Q02750	2.7.12.2	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-5684264 R-HSA-5684264 Reactome Name: MAP3K8 (TPL2)-dependent MAPK1/3 activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome	Developmental Biology Immune System Signal Transduction	R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109860 ( R-HSA-110056; R-HSA-445144 ) R-HSA-109860 Reaction Name: MAP2K1 phosphorylates MAPK3 See in Reactome R-HSA-109863 ( R-HSA-110056 ) R-HSA-109863 Reaction Name: Dissociation of p-T,Y-MAPK3:MAP2K1 See in Reactome R-HSA-112342 ( R-HSA-110056 ) R-HSA-112342 Reaction Name: Inactivation of MAP2K1 by CDK1 See in Reactome R-HSA-451649 ( R-HSA-5684264 ) R-HSA-451649 Reaction Name: TPL2 phosphorylates MEK1, SEK1 See in Reactome R-HSA-5672969 ( R-HSA-5673000 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674366 ( R-HSA-5674135 ) R-HSA-5674366 Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs See in Reactome R-HSA-5674373 ( R-HSA-5674135 ) R-HSA-5674373 Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane See in Reactome R-HSA-5674496 ( R-HSA-5674499 ) R-HSA-5674496 Reaction Name: Activated MAPKs phosphorylate MAP2K1 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9657599 ( R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome
MONDO:0008104	MAP2K1	Q02750	2.7.12.2	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-5684264 R-HSA-5684264 Reactome Name: MAP3K8 (TPL2)-dependent MAPK1/3 activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome	Developmental Biology Immune System Signal Transduction	R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109860 ( R-HSA-110056; R-HSA-445144 ) R-HSA-109860 Reaction Name: MAP2K1 phosphorylates MAPK3 See in Reactome R-HSA-109863 ( R-HSA-110056 ) R-HSA-109863 Reaction Name: Dissociation of p-T,Y-MAPK3:MAP2K1 See in Reactome R-HSA-112342 ( R-HSA-110056 ) R-HSA-112342 Reaction Name: Inactivation of MAP2K1 by CDK1 See in Reactome R-HSA-451649 ( R-HSA-5684264 ) R-HSA-451649 Reaction Name: TPL2 phosphorylates MEK1, SEK1 See in Reactome R-HSA-5672969 ( R-HSA-5673000 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674366 ( R-HSA-5674135 ) R-HSA-5674366 Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs See in Reactome R-HSA-5674373 ( R-HSA-5674135 ) R-HSA-5674373 Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane See in Reactome R-HSA-5674496 ( R-HSA-5674499 ) R-HSA-5674496 Reaction Name: Activated MAPKs phosphorylate MAP2K1 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9657599 ( R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome
MONDO:0008903	MAP3K8	P41279	2.7.11.25	R-HSA-5684264 R-HSA-5684264 Reactome Name: MAP3K8 (TPL2)-dependent MAPK1/3 activation See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome	Immune System	R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-392530 ( R-HSA-389357 ) R-HSA-392530 Reaction Name: p-S400-Cot phosphorylates NIK See in Reactome R-HSA-451634 ( R-HSA-5684264; R-HSA-9020702 ) R-HSA-451634 Reaction Name: NFKB p105, TPL2 (COT) and ABIN2 form a stable complex See in Reactome R-HSA-451649 ( R-HSA-5684264; R-HSA-9020702 ) R-HSA-451649 Reaction Name: TPL2 phosphorylates MEK1, SEK1 See in Reactome R-HSA-5684248 ( R-HSA-5684264; R-HSA-9020702 ) R-HSA-5684248 Reaction Name: SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 See in Reactome R-HSA-5684250 ( R-HSA-5684264; R-HSA-9020702 ) R-HSA-5684250 Reaction Name: SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 See in Reactome R-HSA-5684261 ( R-HSA-5684264; R-HSA-9020702 ) R-HSA-5684261 Reaction Name: MAP3K8 is phosphorylated See in Reactome R-HSA-5684267 ( R-HSA-5684264; R-HSA-9020702 ) R-HSA-5684267 Reaction Name: IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex See in Reactome R-HSA-5684273 ( R-HSA-5684264; R-HSA-9020702 ) R-HSA-5684273 Reaction Name: 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 See in Reactome R-HSA-5684275 ( R-HSA-5684264; R-HSA-9020702 ) R-HSA-5684275 Reaction Name: IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 See in Reactome
MONDO:0013334	CHUK	O15111	2.7.11.10	R-HSA-5684264 R-HSA-5684264 Reactome Name: MAP3K8 (TPL2)-dependent MAPK1/3 activation See in Reactome R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-937039 R-HSA-937039 Reactome Name: IRAK1 recruits IKK complex See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-5607761 R-HSA-5607761 Reactome Name: Dectin-1 mediated noncanonical NF-kB signaling See in Reactome R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-937041 R-HSA-937041 Reactome Name: IKK complex recruitment mediated by RIP1 See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-1236974 R-HSA-1236974 Reactome Name: ER-Phagosome pathway See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome R-HSA-975144 R-HSA-975144 Reactome Name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation See in Reactome R-HSA-445989 R-HSA-445989 Reactome Name: TAK1-dependent IKK and NF-kappa-B activation See in Reactome R-HSA-5357956 R-HSA-5357956 Reactome Name: TNFR1-induced NFkappaB signaling pathway See in Reactome R-HSA-1810476 R-HSA-1810476 Reactome Name: RIP-mediated NFkB activation via ZBP1 See in Reactome R-HSA-5676590 R-HSA-5676590 Reactome Name: NIK-->noncanonical NF-kB signaling See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-1169091 R-HSA-1169091 Reactome Name: Activation of NF-kappaB in B cells See in Reactome R-HSA-168927 R-HSA-168927 Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment See in Reactome R-HSA-2871837 R-HSA-2871837 Reactome Name: FCERI mediated NF-kB activation See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-5668541 R-HSA-5668541 Reactome Name: TNFR2 non-canonical NF-kB pathway See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1606322 R-HSA-1606322 Reactome Name: ZBP1(DAI) mediated induction of type I IFNs See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome	Immune System Signal Transduction	R-HSA-1168637 ( R-HSA-1169091 ) R-HSA-1168637 Reaction Name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK See in Reactome R-HSA-1168638 ( R-HSA-1169091 ) R-HSA-1168638 Reaction Name: Activated IKK phosphorylates I-kappaB See in Reactome R-HSA-1168641 ( R-HSA-1169091 ) R-HSA-1168641 Reaction Name: TAK1 associated with the CBM complex phosphorylates IKKbeta See in Reactome R-HSA-168140 ( R-HSA-1810476; R-HSA-445989; R-HSA-9020702; R-HSA-933542 ) R-HSA-168140 Reaction Name: Active IKK Complex phosphorylates NF-kappa-B inhibitor See in Reactome R-HSA-168184 ( R-HSA-168638; R-HSA-445989; R-HSA-9020702 ) R-HSA-168184 Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex See in Reactome R-HSA-168910 ( R-HSA-1810476 ) R-HSA-168910 Reaction Name: RIP1 facilitates IKK complex phosphorylation See in Reactome R-HSA-198611 ( R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-202500 ( R-HSA-202424 ) R-HSA-202500 Reaction Name: Activation of IKK complex See in Reactome R-HSA-202534 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-202534 Reaction Name: Ubiquitination of NEMO by TRAF6 See in Reactome R-HSA-202541 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-202541 Reaction Name: p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB See in Reactome R-HSA-2730876 ( R-HSA-2871837 ) R-HSA-2730876 Reaction Name: Phosphorylation of IKK-beta by TAK1 See in Reactome R-HSA-451561 ( R-HSA-9020702 ) R-HSA-451561 Reaction Name: NEMO binds polyubiquitinated IRAK1 See in Reactome R-HSA-5357776 ( R-HSA-5357956 ) R-HSA-5357776 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG See in Reactome R-HSA-5357831 ( R-HSA-5357905 ) R-HSA-5357831 Reaction Name: CYLD is phosphorylated by IKK See in Reactome R-HSA-5607720 ( R-HSA-5607761; R-HSA-5607764; R-HSA-5676590 ) R-HSA-5607720 Reaction Name: p100:RELB binds active NIK:p-IKKA dimer See in Reactome R-HSA-5607722 ( R-HSA-5607761; R-HSA-5607764; R-HSA-5676590 ) R-HSA-5607722 Reaction Name: Active NIK phosphorylates IKKA dimer See in Reactome R-HSA-5607723 ( R-HSA-5607761; R-HSA-5607764; R-HSA-5676590 ) R-HSA-5607723 Reaction Name: SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB See in Reactome R-HSA-5607725 ( R-HSA-5607761; R-HSA-5607764; R-HSA-5676590 ) R-HSA-5607725 Reaction Name: SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP See in Reactome R-HSA-5607726 ( R-HSA-5607761; R-HSA-5607764; R-HSA-5676590 ) R-HSA-5607726 Reaction Name: Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB See in Reactome R-HSA-5607742 ( R-HSA-5607764 ) R-HSA-5607742 Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta See in Reactome R-HSA-5609665 ( R-HSA-445989; R-HSA-9020702 ) R-HSA-5609665 Reaction Name: CHUK, IKBKB and IKBKG form IKK complex See in Reactome R-HSA-5626962 ( R-HSA-5357905 ) R-HSA-5626962 Reaction Name: GNB2L1 binds IKKA:IKKB:NEMO See in Reactome R-HSA-5684267 ( R-HSA-5684264; R-HSA-9020702 ) R-HSA-5684267 Reaction Name: IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex See in Reactome R-HSA-5684275 ( R-HSA-5684264; R-HSA-9020702 ) R-HSA-5684275 Reaction Name: IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 See in Reactome R-HSA-8863895 ( R-HSA-1236974 ) R-HSA-8863895 Reaction Name: IKKB phosphorylates SNAP23 See in Reactome R-HSA-9014343 ( R-HSA-168927 ) R-HSA-9014343 Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex See in Reactome R-HSA-933530 ( R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933539 ( R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-937029 ( R-HSA-937041 ) R-HSA-937029 Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1 See in Reactome R-HSA-937032 ( R-HSA-937039 ) R-HSA-937032 Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 See in Reactome R-HSA-975119 ( R-HSA-975144 ) R-HSA-975119 Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. See in Reactome
MONDO:0014113	MAP2K1	Q02750	2.7.12.2	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-5684264 R-HSA-5684264 Reactome Name: MAP3K8 (TPL2)-dependent MAPK1/3 activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome	Developmental Biology Immune System Signal Transduction	R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109860 ( R-HSA-110056; R-HSA-445144 ) R-HSA-109860 Reaction Name: MAP2K1 phosphorylates MAPK3 See in Reactome R-HSA-109863 ( R-HSA-110056 ) R-HSA-109863 Reaction Name: Dissociation of p-T,Y-MAPK3:MAP2K1 See in Reactome R-HSA-112342 ( R-HSA-110056 ) R-HSA-112342 Reaction Name: Inactivation of MAP2K1 by CDK1 See in Reactome R-HSA-451649 ( R-HSA-5684264 ) R-HSA-451649 Reaction Name: TPL2 phosphorylates MEK1, SEK1 See in Reactome R-HSA-5672969 ( R-HSA-5673000 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674366 ( R-HSA-5674135 ) R-HSA-5674366 Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs See in Reactome R-HSA-5674373 ( R-HSA-5674135 ) R-HSA-5674373 Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane See in Reactome R-HSA-5674496 ( R-HSA-5674499 ) R-HSA-5674496 Reaction Name: Activated MAPKs phosphorylate MAP2K1 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9657599 ( R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome
MONDO:0014267	IKBKB	O14920	2.7.11.10 2.7.11.1	R-HSA-5684264 R-HSA-5684264 Reactome Name: MAP3K8 (TPL2)-dependent MAPK1/3 activation See in Reactome R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-937039 R-HSA-937039 Reactome Name: IRAK1 recruits IKK complex See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-937041 R-HSA-937041 Reactome Name: IKK complex recruitment mediated by RIP1 See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-1236974 R-HSA-1236974 Reactome Name: ER-Phagosome pathway See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome R-HSA-975144 R-HSA-975144 Reactome Name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation See in Reactome R-HSA-445989 R-HSA-445989 Reactome Name: TAK1-dependent IKK and NF-kappa-B activation See in Reactome R-HSA-5357956 R-HSA-5357956 Reactome Name: TNFR1-induced NFkappaB signaling pathway See in Reactome R-HSA-1810476 R-HSA-1810476 Reactome Name: RIP-mediated NFkB activation via ZBP1 See in Reactome R-HSA-209543 R-HSA-209543 Reactome Name: p75NTR recruits signalling complexes See in Reactome R-HSA-209560 R-HSA-209560 Reactome Name: NF-kB is activated and signals survival See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-1169091 R-HSA-1169091 Reactome Name: Activation of NF-kappaB in B cells See in Reactome R-HSA-168927 R-HSA-168927 Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment See in Reactome R-HSA-2871837 R-HSA-2871837 Reactome Name: FCERI mediated NF-kB activation See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1606322 R-HSA-1606322 Reactome Name: ZBP1(DAI) mediated induction of type I IFNs See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-193639 R-HSA-193639 Reactome Name: p75NTR signals via NF-kB See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome	Immune System Signal Transduction	R-HSA-1168637 ( R-HSA-1169091 ) R-HSA-1168637 Reaction Name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK See in Reactome R-HSA-1168638 ( R-HSA-1169091 ) R-HSA-1168638 Reaction Name: Activated IKK phosphorylates I-kappaB See in Reactome R-HSA-1168641 ( R-HSA-1169091 ) R-HSA-1168641 Reaction Name: TAK1 associated with the CBM complex phosphorylates IKKbeta See in Reactome R-HSA-168140 ( R-HSA-1810476; R-HSA-445989; R-HSA-9020702; R-HSA-933542 ) R-HSA-168140 Reaction Name: Active IKK Complex phosphorylates NF-kappa-B inhibitor See in Reactome R-HSA-168184 ( R-HSA-168638; R-HSA-445989; R-HSA-9020702 ) R-HSA-168184 Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex See in Reactome R-HSA-168910 ( R-HSA-1810476 ) R-HSA-168910 Reaction Name: RIP1 facilitates IKK complex phosphorylation See in Reactome R-HSA-193641 ( R-HSA-209543 ) R-HSA-193641 Reaction Name: IKK-beta is recruited See in Reactome R-HSA-193703 ( R-HSA-209560 ) R-HSA-193703 Reaction Name: IKKbeta is activated See in Reactome R-HSA-193705 ( R-HSA-209560 ) R-HSA-193705 Reaction Name: IKKbeta phosphorylates IkB causing NF-kB to dissociate See in Reactome R-HSA-202500 ( R-HSA-202424 ) R-HSA-202500 Reaction Name: Activation of IKK complex See in Reactome R-HSA-202534 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-202534 Reaction Name: Ubiquitination of NEMO by TRAF6 See in Reactome R-HSA-202541 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-202541 Reaction Name: p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB See in Reactome R-HSA-209087 ( R-HSA-9020702 ) R-HSA-209087 Reaction Name: IKBA is phosphorylated by Phospho IKKB kinase See in Reactome R-HSA-2730876 ( R-HSA-2871837 ) R-HSA-2730876 Reaction Name: Phosphorylation of IKK-beta by TAK1 See in Reactome R-HSA-451561 ( R-HSA-9020702 ) R-HSA-451561 Reaction Name: NEMO binds polyubiquitinated IRAK1 See in Reactome R-HSA-5357776 ( R-HSA-5357956 ) R-HSA-5357776 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG See in Reactome R-HSA-5357831 ( R-HSA-5357905 ) R-HSA-5357831 Reaction Name: CYLD is phosphorylated by IKK See in Reactome R-HSA-5607742 ( R-HSA-5607764 ) R-HSA-5607742 Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta See in Reactome R-HSA-5609665 ( R-HSA-445989; R-HSA-9020702 ) R-HSA-5609665 Reaction Name: CHUK, IKBKB and IKBKG form IKK complex See in Reactome R-HSA-5626962 ( R-HSA-5357905 ) R-HSA-5626962 Reaction Name: GNB2L1 binds IKKA:IKKB:NEMO See in Reactome R-HSA-5684267 ( R-HSA-5684264; R-HSA-9020702 ) R-HSA-5684267 Reaction Name: IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex See in Reactome R-HSA-5684275 ( R-HSA-5684264; R-HSA-9020702 ) R-HSA-5684275 Reaction Name: IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 See in Reactome R-HSA-8863895 ( R-HSA-1236974 ) R-HSA-8863895 Reaction Name: IKKB phosphorylates SNAP23 See in Reactome R-HSA-9014343 ( R-HSA-168927 ) R-HSA-9014343 Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex See in Reactome R-HSA-933530 ( R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933539 ( R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-937029 ( R-HSA-937041 ) R-HSA-937029 Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1 See in Reactome R-HSA-937032 ( R-HSA-937039 ) R-HSA-937032 Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 See in Reactome R-HSA-975119 ( R-HSA-975144 ) R-HSA-975119 Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. See in Reactome
MONDO:0032599	IKBKB	O14920	2.7.11.10 2.7.11.1	R-HSA-5684264 R-HSA-5684264 Reactome Name: MAP3K8 (TPL2)-dependent MAPK1/3 activation See in Reactome R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-937039 R-HSA-937039 Reactome Name: IRAK1 recruits IKK complex See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-937041 R-HSA-937041 Reactome Name: IKK complex recruitment mediated by RIP1 See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-1236974 R-HSA-1236974 Reactome Name: ER-Phagosome pathway See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome R-HSA-975144 R-HSA-975144 Reactome Name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation See in Reactome R-HSA-445989 R-HSA-445989 Reactome Name: TAK1-dependent IKK and NF-kappa-B activation See in Reactome R-HSA-5357956 R-HSA-5357956 Reactome Name: TNFR1-induced NFkappaB signaling pathway See in Reactome R-HSA-1810476 R-HSA-1810476 Reactome Name: RIP-mediated NFkB activation via ZBP1 See in Reactome R-HSA-209543 R-HSA-209543 Reactome Name: p75NTR recruits signalling complexes See in Reactome R-HSA-209560 R-HSA-209560 Reactome Name: NF-kB is activated and signals survival See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-1169091 R-HSA-1169091 Reactome Name: Activation of NF-kappaB in B cells See in Reactome R-HSA-168927 R-HSA-168927 Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment See in Reactome R-HSA-2871837 R-HSA-2871837 Reactome Name: FCERI mediated NF-kB activation See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1606322 R-HSA-1606322 Reactome Name: ZBP1(DAI) mediated induction of type I IFNs See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-193639 R-HSA-193639 Reactome Name: p75NTR signals via NF-kB See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome	Immune System Signal Transduction	R-HSA-1168637 ( R-HSA-1169091 ) R-HSA-1168637 Reaction Name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK See in Reactome R-HSA-1168638 ( R-HSA-1169091 ) R-HSA-1168638 Reaction Name: Activated IKK phosphorylates I-kappaB See in Reactome R-HSA-1168641 ( R-HSA-1169091 ) R-HSA-1168641 Reaction Name: TAK1 associated with the CBM complex phosphorylates IKKbeta See in Reactome R-HSA-168140 ( R-HSA-1810476; R-HSA-445989; R-HSA-9020702; R-HSA-933542 ) R-HSA-168140 Reaction Name: Active IKK Complex phosphorylates NF-kappa-B inhibitor See in Reactome R-HSA-168184 ( R-HSA-168638; R-HSA-445989; R-HSA-9020702 ) R-HSA-168184 Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex See in Reactome R-HSA-168910 ( R-HSA-1810476 ) R-HSA-168910 Reaction Name: RIP1 facilitates IKK complex phosphorylation See in Reactome R-HSA-193641 ( R-HSA-209543 ) R-HSA-193641 Reaction Name: IKK-beta is recruited See in Reactome R-HSA-193703 ( R-HSA-209560 ) R-HSA-193703 Reaction Name: IKKbeta is activated See in Reactome R-HSA-193705 ( R-HSA-209560 ) R-HSA-193705 Reaction Name: IKKbeta phosphorylates IkB causing NF-kB to dissociate See in Reactome R-HSA-202500 ( R-HSA-202424 ) R-HSA-202500 Reaction Name: Activation of IKK complex See in Reactome R-HSA-202534 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-202534 Reaction Name: Ubiquitination of NEMO by TRAF6 See in Reactome R-HSA-202541 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-202541 Reaction Name: p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB See in Reactome R-HSA-209087 ( R-HSA-9020702 ) R-HSA-209087 Reaction Name: IKBA is phosphorylated by Phospho IKKB kinase See in Reactome R-HSA-2730876 ( R-HSA-2871837 ) R-HSA-2730876 Reaction Name: Phosphorylation of IKK-beta by TAK1 See in Reactome R-HSA-451561 ( R-HSA-9020702 ) R-HSA-451561 Reaction Name: NEMO binds polyubiquitinated IRAK1 See in Reactome R-HSA-5357776 ( R-HSA-5357956 ) R-HSA-5357776 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG See in Reactome R-HSA-5357831 ( R-HSA-5357905 ) R-HSA-5357831 Reaction Name: CYLD is phosphorylated by IKK See in Reactome R-HSA-5607742 ( R-HSA-5607764 ) R-HSA-5607742 Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta See in Reactome R-HSA-5609665 ( R-HSA-445989; R-HSA-9020702 ) R-HSA-5609665 Reaction Name: CHUK, IKBKB and IKBKG form IKK complex See in Reactome R-HSA-5626962 ( R-HSA-5357905 ) R-HSA-5626962 Reaction Name: GNB2L1 binds IKKA:IKKB:NEMO See in Reactome R-HSA-5684267 ( R-HSA-5684264; R-HSA-9020702 ) R-HSA-5684267 Reaction Name: IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex See in Reactome R-HSA-5684275 ( R-HSA-5684264; R-HSA-9020702 ) R-HSA-5684275 Reaction Name: IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 See in Reactome R-HSA-8863895 ( R-HSA-1236974 ) R-HSA-8863895 Reaction Name: IKKB phosphorylates SNAP23 See in Reactome R-HSA-9014343 ( R-HSA-168927 ) R-HSA-9014343 Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex See in Reactome R-HSA-933530 ( R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933539 ( R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-937029 ( R-HSA-937041 ) R-HSA-937029 Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1 See in Reactome R-HSA-937032 ( R-HSA-937039 ) R-HSA-937032 Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 See in Reactome R-HSA-975119 ( R-HSA-975144 ) R-HSA-975119 Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. See in Reactome