DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-5676594)

Number of enzymes:	2
Number of disease:	2
Number of reactomes:	10
Number of reactions:	43

Search results (Reactome ID: R-HSA-5676594)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0013920	TRAF3	Q13114	2.3.2.27	R-HSA-9013973 R-HSA-9013973 Reactome Name: TICAM1-dependent activation of IRF3/IRF7 See in Reactome R-HSA-5668541 R-HSA-5668541 Reactome Name: TNFR2 non-canonical NF-kB pathway See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-5676594 R-HSA-5676594 Reactome Name: TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Immune System Metabolism of proteins	R-HSA-166245 ( R-HSA-936964 ) R-HSA-166245 Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-2201338 ( R-HSA-936964 ) R-HSA-2201338 Reaction Name: TRAF3 binds TICAM1:activated TLR4 complex See in Reactome R-HSA-2213017 ( R-HSA-936964 ) R-HSA-2213017 Reaction Name: Auto-ubiquitination of TRAF3 See in Reactome R-HSA-5362486 ( R-HSA-936964 ) R-HSA-5362486 Reaction Name: TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4 See in Reactome R-HSA-5362500 ( R-HSA-936964 ) R-HSA-5362500 Reaction Name: TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 See in Reactome R-HSA-5668414 ( R-HSA-5668541 ) R-HSA-5668414 Reaction Name: TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK See in Reactome R-HSA-5668417 ( R-HSA-5668541 ) R-HSA-5668417 Reaction Name: cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer See in Reactome R-HSA-5668454 ( R-HSA-5668541 ) R-HSA-5668454 Reaction Name: K63polyUb-cIAP1,2 ubiquitinates TRAF3 See in Reactome R-HSA-5668481 ( R-HSA-5668541 ) R-HSA-5668481 Reaction Name: Protesomal degradation of K48polyUb-TRAF3 See in Reactome R-HSA-5668534 ( R-HSA-5668541 ) R-HSA-5668534 Reaction Name: cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK See in Reactome R-HSA-5668543 ( R-HSA-5668541 ) R-HSA-5668543 Reaction Name: TRAF3:NIK binds TRAF2:cIAP1/2 See in Reactome R-HSA-5676593 ( R-HSA-5668541; R-HSA-5676594 ) R-HSA-5676593 Reaction Name: TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR See in Reactome R-HSA-5676595 ( R-HSA-5668541; R-HSA-5676594 ) R-HSA-5676595 Reaction Name: TRAFs bind RANK:RANKL See in Reactome R-HSA-5676596 ( R-HSA-5668541; R-HSA-5676594 ) R-HSA-5676596 Reaction Name: TRAF3 binds BAFFR:BAFF See in Reactome R-HSA-5676597 ( R-HSA-5668541; R-HSA-5676594 ) R-HSA-5676597 Reaction Name: TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 See in Reactome R-HSA-5676598 ( R-HSA-5668541; R-HSA-5676594 ) R-HSA-5676598 Reaction Name: TRAF2:cIAP1/2 complex binds FN14:TWEAK See in Reactome R-HSA-5690843 ( R-HSA-5689896 ) R-HSA-5690843 Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA See in Reactome R-HSA-9013974 ( R-HSA-9013973 ) R-HSA-9013974 Reaction Name: Auto-ubiquitination of TRAF3 within activated TLR3 complex See in Reactome R-HSA-9013978 ( R-HSA-9013973 ) R-HSA-9013978 Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex See in Reactome R-HSA-9013979 ( R-HSA-9013973 ) R-HSA-9013979 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 See in Reactome R-HSA-9013985 ( R-HSA-9013973 ) R-HSA-9013985 Reaction Name: TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3 See in Reactome R-HSA-9013986 ( R-HSA-9013973 ) R-HSA-9013986 Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation See in Reactome R-HSA-9013990 ( R-HSA-9013973 ) R-HSA-9013990 Reaction Name: TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA See in Reactome R-HSA-9013992 ( R-HSA-9013973 ) R-HSA-9013992 Reaction Name: TRAF3 binds to TRIF:activated TLR3 complex See in Reactome R-HSA-918225 ( R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918227 ( R-HSA-918233 ) R-HSA-918227 Reaction Name: Recruitment of TRAF3 to MAVS See in Reactome R-HSA-918229 ( R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918232 ( R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-936381 ( R-HSA-5689896; R-HSA-936440 ) R-HSA-936381 Reaction Name: OTUD5 deubiquitinates TRAF3 See in Reactome R-HSA-936475 ( R-HSA-936440 ) R-HSA-936475 Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216 See in Reactome R-HSA-936941 ( R-HSA-936964 ) R-HSA-936941 Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation See in Reactome R-HSA-9705137 ( R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705320 ( R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome
MONDO:0018642	MAP3K14	Q99558	2.7.11.25	R-HSA-5607761 R-HSA-5607761 Reactome Name: Dectin-1 mediated noncanonical NF-kB signaling See in Reactome R-HSA-5668541 R-HSA-5668541 Reactome Name: TNFR2 non-canonical NF-kB pathway See in Reactome R-HSA-5676590 R-HSA-5676590 Reactome Name: NIK-->noncanonical NF-kB signaling See in Reactome R-HSA-5676594 R-HSA-5676594 Reactome Name: TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome	Immune System	R-HSA-392530 ( R-HSA-389357 ) R-HSA-392530 Reaction Name: p-S400-Cot phosphorylates NIK See in Reactome R-HSA-5607720 ( R-HSA-5607761; R-HSA-5668541; R-HSA-5676590 ) R-HSA-5607720 Reaction Name: p100:RELB binds active NIK:p-IKKA dimer See in Reactome R-HSA-5607721 ( R-HSA-5607761; R-HSA-5668541; R-HSA-5676590 ) R-HSA-5607721 Reaction Name: Activation of NIK See in Reactome R-HSA-5607722 ( R-HSA-5607761; R-HSA-5668541; R-HSA-5676590 ) R-HSA-5607722 Reaction Name: Active NIK phosphorylates IKKA dimer See in Reactome R-HSA-5607723 ( R-HSA-5607761; R-HSA-5668541; R-HSA-5676590 ) R-HSA-5607723 Reaction Name: SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB See in Reactome R-HSA-5607725 ( R-HSA-5607761; R-HSA-5668541; R-HSA-5676590 ) R-HSA-5607725 Reaction Name: SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP See in Reactome R-HSA-5607726 ( R-HSA-5607761; R-HSA-5668541; R-HSA-5676590 ) R-HSA-5607726 Reaction Name: Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB See in Reactome R-HSA-5668414 ( R-HSA-5668541 ) R-HSA-5668414 Reaction Name: TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK See in Reactome R-HSA-5668417 ( R-HSA-5668541 ) R-HSA-5668417 Reaction Name: cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer See in Reactome R-HSA-5668454 ( R-HSA-5668541 ) R-HSA-5668454 Reaction Name: K63polyUb-cIAP1,2 ubiquitinates TRAF3 See in Reactome R-HSA-5668481 ( R-HSA-5668541 ) R-HSA-5668481 Reaction Name: Protesomal degradation of K48polyUb-TRAF3 See in Reactome R-HSA-5668520 ( R-HSA-5668541 ) R-HSA-5668520 Reaction Name: 26Sproteasome degrades K48polyUb-NIK See in Reactome R-HSA-5668534 ( R-HSA-5668541 ) R-HSA-5668534 Reaction Name: cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK See in Reactome R-HSA-5668543 ( R-HSA-5668541 ) R-HSA-5668543 Reaction Name: TRAF3:NIK binds TRAF2:cIAP1/2 See in Reactome R-HSA-5668545 ( R-HSA-5668541; R-HSA-5676590 ) R-HSA-5668545 Reaction Name: NIK autophosphorylates on T559 See in Reactome R-HSA-5676593 ( R-HSA-5668541; R-HSA-5676594 ) R-HSA-5676593 Reaction Name: TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR See in Reactome R-HSA-5676595 ( R-HSA-5668541; R-HSA-5676594 ) R-HSA-5676595 Reaction Name: TRAFs bind RANK:RANKL See in Reactome R-HSA-5676596 ( R-HSA-5668541; R-HSA-5676594 ) R-HSA-5676596 Reaction Name: TRAF3 binds BAFFR:BAFF See in Reactome R-HSA-5676597 ( R-HSA-5668541; R-HSA-5676594 ) R-HSA-5676597 Reaction Name: TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 See in Reactome R-HSA-5676598 ( R-HSA-5668541; R-HSA-5676594 ) R-HSA-5676598 Reaction Name: TRAF2:cIAP1/2 complex binds FN14:TWEAK See in Reactome