MONDO:0001056 |
ERBB2 |
P04626 |
2.7.10.1
|
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-1251932
R-HSA-1251932
Reactome Name: PLCG1 events in ERBB2 signaling
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-1257604
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-1306955
R-HSA-1306955
Reactome Name: GRB7 events in ERBB2 signaling
See in Reactome
R-HSA-8866910
R-HSA-8866910
Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
See in Reactome
R-HSA-9652282
R-HSA-9652282
Reactome Name: Drug-mediated inhibition of ERBB2 signaling
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-1227986
R-HSA-6785631
R-HSA-8847993
R-HSA-8847993
Reactome Name: ERBB2 Activates PTK6 Signaling
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-5673001
|
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-8848021
R-HSA-8864260
R-HSA-8864260
Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-9675108
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-373755
R-HSA-422475
R-HSA-73857
R-HSA-5684996
R-HSA-400685
R-HSA-1266738
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
|
Gene expression (Transcription)
Signal Transduction
Developmental Biology
|
R-HSA-1250189
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250195
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250195
Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers
See in Reactome
R-HSA-1250346
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1250463
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250486
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250486
Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250488
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1250488
Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer
See in Reactome
R-HSA-1250498
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1251922
(
R-HSA-1227986;
R-HSA-1251932
)
R-HSA-1251922
Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2
See in Reactome
R-HSA-1251944
(
R-HSA-1227986;
R-HSA-1251932
)
R-HSA-1306953
(
R-HSA-1227986;
R-HSA-1306955
)
R-HSA-1306953
Reaction Name: GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306963
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306963
Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306969
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1306969
Reaction Name: GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1306972
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1306979
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1358792
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358792
Reaction Name: RNF41 ubiquitinates activated ERBB3
See in Reactome
R-HSA-1358798
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358798
Reaction Name: RNF41 binds neuregulin-activated ERBB3
See in Reactome
R-HSA-1918092
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1918092
Reaction Name: CHIP (STUB1) mediates ubiquitination of ERBB2
See in Reactome
R-HSA-1918095
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1918095
Reaction Name: CUL5 mediates ubiquitination of ERBB2
See in Reactome
R-HSA-1963563
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1963563
Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2
See in Reactome
R-HSA-1963578
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1963578
Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1963581
(
R-HSA-1227986
)
R-HSA-1963581
Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
See in Reactome
R-HSA-1963582
(
R-HSA-1227986
)
R-HSA-1963582
Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-373750
(
R-HSA-416572
)
R-HSA-373750
Reaction Name: SEMA4D interacts with Plexin-B1:ErbB2
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-416594
(
R-HSA-416572
)
R-HSA-416594
Reaction Name: LARG and PDZ-RhoGEF binds to Plexin-B1
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-6785636
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-6785636
Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1
See in Reactome
R-HSA-6785648
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-8847995
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8847995
Reaction Name: Activated ERBB2 binds PTK6 (BRK)
See in Reactome
R-HSA-8848005
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8848005
Reaction Name: ERBB2 promotes PTK6 autophosphorylation
See in Reactome
R-HSA-8863804
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8863804
Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
See in Reactome
R-HSA-8864105
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8864105
Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers
See in Reactome
R-HSA-8864125
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8864125
Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248
See in Reactome
R-HSA-8864466
(
R-HSA-8866910
)
R-HSA-8864466
Reaction Name: TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression
See in Reactome
R-HSA-9652264
(
R-HSA-1227986;
R-HSA-9652282
)
R-HSA-9652277
(
R-HSA-1227986;
R-HSA-9652282
)
R-HSA-9665726
(
R-HSA-1227986;
R-HSA-9652282
)
|
MONDO:0001056 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399;
R-HSA-74751
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1236394;
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1236394;
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654687;
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654687;
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654687;
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654687;
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399;
R-HSA-74751
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0001187 |
HRAS |
P01112 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-2682334
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112399;
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1236394;
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1236394;
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-177929;
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-177929;
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392;
R-HSA-416476;
R-HSA-881907
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-4093331
(
R-HSA-3928662
)
R-HSA-4093339
(
R-HSA-3928662
)
R-HSA-4093339
Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-4420097;
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654687;
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654687;
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654687;
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-8939211;
R-HSA-9009391;
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-8939211;
R-HSA-9009391;
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-8939211;
R-HSA-9009391;
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9660557
(
R-HSA-5673001
)
R-HSA-9660557
Reaction Name: RAS:GTP binds RAL GDS proteins
See in Reactome
|
MONDO:0001187 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0001187 |
FGFR3 |
P22607 |
2.7.10.1
|
R-HSA-190372
R-HSA-190372
Reactome Name: FGFR3c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-5654227
R-HSA-5654227
Reactome Name: Phospholipase C-mediated cascade; FGFR3
See in Reactome
R-HSA-190371
R-HSA-190371
Reactome Name: FGFR3b ligand binding and activation
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654710
R-HSA-109704
R-HSA-5654706
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654704
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5684996
R-HSA-190239
R-HSA-190239
Reactome Name: FGFR3 ligand binding and activation
See in Reactome
R-HSA-190236
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-5654741
R-HSA-74752
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190261
(
R-HSA-190372
)
R-HSA-190263
(
R-HSA-190371
)
R-HSA-190385
(
R-HSA-190371
)
R-HSA-190385
Reaction Name: Autocatalytic phosphorylation of FGFR3b
See in Reactome
R-HSA-190388
(
R-HSA-190372
)
R-HSA-190388
Reaction Name: Autocatalytic phosphorylation of FGFR3c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654148
(
R-HSA-5654227
)
R-HSA-5654148
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR3
See in Reactome
R-HSA-5654222
(
R-HSA-5654227
)
R-HSA-5654222
Reaction Name: Activated FGFR3 phosphorylates PLCG1
See in Reactome
R-HSA-5654224
(
R-HSA-5654227
)
R-HSA-5654408
(
R-HSA-5654706
)
R-HSA-5654408
Reaction Name: Activated FGFR3 phosphorylates FRS2
See in Reactome
R-HSA-5654409
(
R-HSA-5654706
)
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654416
(
R-HSA-5654706
)
R-HSA-5654416
Reaction Name: Activated FGFR3:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654565
(
R-HSA-5654732
)
R-HSA-5654565
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2.
See in Reactome
R-HSA-5654623
(
R-HSA-5654706
)
R-HSA-5654625
(
R-HSA-5654704
)
R-HSA-5654628
(
R-HSA-5654706
)
R-HSA-5654628
Reaction Name: Activated FGFR3 phosphorylates FRS3
See in Reactome
R-HSA-5654631
(
R-HSA-5654706
)
R-HSA-5654631
Reaction Name: Activated FGFR3 phosphorylates PPTN11
See in Reactome
R-HSA-5654633
(
R-HSA-5654706
)
R-HSA-5654633
Reaction Name: Activated FGFR3:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654634
(
R-HSA-5654704
)
R-HSA-5654634
Reaction Name: Activated FGFR3 phosphorylates SHC1
See in Reactome
R-HSA-5654637
(
R-HSA-5654710
)
R-HSA-5654637
Reaction Name: Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654641
(
R-HSA-5654710
)
R-HSA-5654641
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654646
(
R-HSA-5654704
)
R-HSA-5654646
Reaction Name: Activated FGFR3:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654679
(
R-HSA-5654732
)
R-HSA-5654679
Reaction Name: CBL ubiquitinates FRS2 and FGFR3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654730
(
R-HSA-5654732
)
R-HSA-5654730
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0002911 |
MONDO:0002911
Disease Name: brain stem glioma
All associated enzymes in DAR:
ACVR1
EGFR
EGFR |
P00533 |
2.7.10.1
|
R-HSA-445144
R-HSA-1251932
R-HSA-1251932
Reactome Name: PLCG1 events in ERBB2 signaling
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-180292
R-HSA-1236394
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-5673001
R-HSA-9013507
R-HSA-9013507
Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus
See in Reactome
R-HSA-1257604
R-HSA-177929
R-HSA-8857538
R-HSA-8857538
Reactome Name: PTK6 promotes HIF1A stabilization
See in Reactome
R-HSA-8856828
R-HSA-8856825
R-HSA-8856825
Reactome Name: Cargo recognition for clathrin-mediated endocytosis
See in Reactome
R-HSA-1227986
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-180336
R-HSA-8847993
R-HSA-8847993
Reactome Name: ERBB2 Activates PTK6 Signaling
See in Reactome
R-HSA-212718
R-HSA-212718
Reactome Name: EGFR interacts with phospholipase C-gamma
See in Reactome
R-HSA-182971
R-HSA-179812
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-8866910
R-HSA-8866910
Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-6785631
|
R-HSA-9012852
R-HSA-157118
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-8848021
R-HSA-5684996
R-HSA-1266738
R-HSA-73857
R-HSA-8864260
R-HSA-8864260
Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5653656
R-HSA-373760
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-372790
R-HSA-416476
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-162582
|
Developmental Biology
Gene expression (Transcription)
Vesicle-mediated transport
Signal Transduction
|
R-HSA-1250195
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250195
Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers
See in Reactome
R-HSA-1250463
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250486
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250486
Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250488
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1250488
Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer
See in Reactome
R-HSA-1250498
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1251922
(
R-HSA-1227986;
R-HSA-1251932
)
R-HSA-1251922
Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2
See in Reactome
R-HSA-1251944
(
R-HSA-1227986;
R-HSA-1251932
)
R-HSA-1306957
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306963
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306963
Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-177922
(
R-HSA-177929
)
R-HSA-177923
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-177924
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177924
Reaction Name: Dephosphorylation of Gab1 by SHP2
See in Reactome
R-HSA-177925
(
R-HSA-177929;
R-HSA-180336
)
R-HSA-177925
Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex
See in Reactome
R-HSA-177926
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177926
Reaction Name: Dephosphorylation of PAG by SHP2
See in Reactome
R-HSA-177927
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177930
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177930
Reaction Name: GAB1 phosphorylation by EGFR kinase
See in Reactome
R-HSA-177933
(
R-HSA-177929;
R-HSA-180336
)
R-HSA-177933
Reaction Name: SHC1 phosphorylation by phosphorylated EGFR
See in Reactome
R-HSA-177934
(
R-HSA-177929
)
R-HSA-177935
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177935
Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR
See in Reactome
R-HSA-177936
(
R-HSA-177929;
R-HSA-180336
)
R-HSA-177936
Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR
See in Reactome
R-HSA-177937
(
R-HSA-177929
)
R-HSA-177937
Reaction Name: Phosphorylation of EGFR by SRC kinase
See in Reactome
R-HSA-177938
(
R-HSA-177929;
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177939
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-177941
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177941
Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR
See in Reactome
R-HSA-177942
(
R-HSA-177929
)
R-HSA-177943
(
R-HSA-177929;
R-HSA-179812
)
R-HSA-177943
Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex
See in Reactome
R-HSA-177944
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177944
Reaction Name: Activation of SHP2 through the binding to phospho-Gab1
See in Reactome
R-HSA-177945
(
R-HSA-177929;
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-182969
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-182969
Reaction Name: Phosphorylation of CBL (EGFR:CBL)
See in Reactome
R-HSA-182986
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-182986
Reaction Name: CBL-mediated ubiquitination of CIN85
See in Reactome
R-HSA-182990
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-182990
Reaction Name: Sprouty sequesters CBL away from active EGFR
See in Reactome
R-HSA-182993
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-182993
Reaction Name: Ubiquitination of stimulated EGFR (CBL)
See in Reactome
R-HSA-182994
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-182994
Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles
See in Reactome
R-HSA-183002
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183002
Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85
See in Reactome
R-HSA-183036
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183036
Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2)
See in Reactome
R-HSA-183051
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183055
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183058
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183058
Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL)
See in Reactome
R-HSA-183067
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183067
Reaction Name: Localization of CBL:GRB2 to the membrane
See in Reactome
R-HSA-183072
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183072
Reaction Name: EGFR non-clathrin mediated endocytosis
See in Reactome
R-HSA-183084
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183084
Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix
See in Reactome
R-HSA-183089
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183089
Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty
See in Reactome
R-HSA-1963563
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1963563
Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2
See in Reactome
R-HSA-1963578
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1963578
Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1963581
(
R-HSA-1227986
)
R-HSA-1963581
Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
See in Reactome
R-HSA-1963582
(
R-HSA-1227986
)
R-HSA-1963582
Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4
See in Reactome
R-HSA-1977959
(
R-HSA-1236394
)
R-HSA-1977959
Reaction Name: ERBB4 forms heterodimers with EGFR
See in Reactome
R-HSA-212706
(
R-HSA-177929;
R-HSA-212718
)
R-HSA-212706
Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor
See in Reactome
R-HSA-212710
(
R-HSA-177929;
R-HSA-212718
)
R-HSA-212710
Reaction Name: EGFR activates PLC-gamma1 by phosphorylation
See in Reactome
R-HSA-212713
(
R-HSA-177929;
R-HSA-212718
)
R-HSA-212713
Reaction Name: Active PLC-gamma1 dissociates from EGFR
See in Reactome
R-HSA-2179387
(
R-HSA-2179392;
R-HSA-416476;
R-HSA-881907
)
R-HSA-2179387
Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor
See in Reactome
R-HSA-2179407
(
R-HSA-2179392;
R-HSA-416476;
R-HSA-881907
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2179415
(
R-HSA-2179392;
R-HSA-416476;
R-HSA-881907
)
R-HSA-2179415
Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-445069
(
R-HSA-445144
)
R-HSA-445069
Reaction Name: L1-EGFR trans-heterodimerization
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-6785636
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-6785636
Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1
See in Reactome
R-HSA-6785648
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-8847995
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8847995
Reaction Name: Activated ERBB2 binds PTK6 (BRK)
See in Reactome
R-HSA-8848005
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8848005
Reaction Name: ERBB2 promotes PTK6 autophosphorylation
See in Reactome
R-HSA-8857549
(
R-HSA-8857538
)
R-HSA-8857549
Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB
See in Reactome
R-HSA-8857555
(
R-HSA-8857538
)
R-HSA-8857565
(
R-HSA-8857538
)
R-HSA-8857565
Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139
See in Reactome
R-HSA-8857577
(
R-HSA-8857538
)
R-HSA-8857577
Reaction Name: LINC01139 facilitates PTK6 autophosphorylation
See in Reactome
R-HSA-8857583
(
R-HSA-8857538
)
R-HSA-8857583
Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6
See in Reactome
R-HSA-8857925
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-8857925
Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307
See in Reactome
R-HSA-8863804
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8863804
Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
See in Reactome
R-HSA-8864029
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-8864029
Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172)
See in Reactome
R-HSA-8864105
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8864105
Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers
See in Reactome
R-HSA-8864125
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8864125
Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248
See in Reactome
R-HSA-8866279
(
R-HSA-8856825;
R-HSA-8856828
)
R-HSA-8866279
Reaction Name: Epsin family proteins bind ubiquitinated cargo
See in Reactome
R-HSA-8867041
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-8867044
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-8867044
Reaction Name: EGFR binds EPS15, EPN1, EPS15L1
See in Reactome
R-HSA-8867047
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-8867754
(
R-HSA-8856828
)
R-HSA-8867754
Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit
See in Reactome
R-HSA-8867756
(
R-HSA-8856828
)
R-HSA-8867756
Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
See in Reactome
R-HSA-8868071
(
R-HSA-8856828
)
R-HSA-8868072
(
R-HSA-8856828
)
R-HSA-8868072
Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
See in Reactome
R-HSA-8868230
(
R-HSA-8856828
)
R-HSA-8868230
Reaction Name: SNX9 recruits components of the actin polymerizing machinery
See in Reactome
R-HSA-8868236
(
R-HSA-8856828
)
R-HSA-8868236
Reaction Name: BAR domain proteins recruit dynamin
See in Reactome
R-HSA-8868648
(
R-HSA-8856828
)
R-HSA-8868648
Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P
See in Reactome
R-HSA-8868651
(
R-HSA-8856828
)
R-HSA-8868651
Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit
See in Reactome
R-HSA-8868658
(
R-HSA-8856828
)
R-HSA-8868658
Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
See in Reactome
R-HSA-8868659
(
R-HSA-8856828
)
R-HSA-8868659
Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle
See in Reactome
R-HSA-8868660
(
R-HSA-8856828
)
R-HSA-8868660
Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
See in Reactome
R-HSA-8868661
(
R-HSA-8856828
)
R-HSA-8868661
Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission
See in Reactome
R-HSA-8869438
(
R-HSA-8856828
)
R-HSA-8869438
Reaction Name: Dissociation of clathrin-associated proteins
See in Reactome
R-HSA-8871193
(
R-HSA-8856828
)
R-HSA-8871193
Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2
See in Reactome
R-HSA-8871194
(
R-HSA-8856828
)
R-HSA-8874797
(
R-HSA-8866910
)
R-HSA-8874797
Reaction Name: EGFR gene expression is stimulated by TFAP2C
See in Reactome
R-HSA-8951490
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-8951490
Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85
See in Reactome
R-HSA-9018572
(
R-HSA-9013507
)
R-HSA-9018573
(
R-HSA-9013507
)
R-HSA-9625465
(
R-HSA-8939211;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9625465
Reaction Name: E2-mediated FOS gene expression
See in Reactome
R-HSA-9625482
(
R-HSA-8939211;
R-HSA-9009391
)
R-HSA-9625487
(
R-HSA-8939211;
R-HSA-9009391
)
R-HSA-9625487
Reaction Name: PTK2 autophosphorylates downstream of EGFR
See in Reactome
R-HSA-9634702
(
R-HSA-8857538
)
R-HSA-9634702
Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2
See in Reactome
R-HSA-9674531
(
R-HSA-177929
)
|
MONDO:0002974 |
FGFR3 |
P22607 |
2.7.10.1
|
R-HSA-190372
R-HSA-190372
Reactome Name: FGFR3c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-5654227
R-HSA-5654227
Reactome Name: Phospholipase C-mediated cascade; FGFR3
See in Reactome
R-HSA-190371
R-HSA-190371
Reactome Name: FGFR3b ligand binding and activation
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654710
R-HSA-109704
R-HSA-5654706
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654704
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5684996
R-HSA-190239
R-HSA-190239
Reactome Name: FGFR3 ligand binding and activation
See in Reactome
R-HSA-190236
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-5654741
R-HSA-74752
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190261
(
R-HSA-190372
)
R-HSA-190263
(
R-HSA-190371
)
R-HSA-190385
(
R-HSA-190371
)
R-HSA-190385
Reaction Name: Autocatalytic phosphorylation of FGFR3b
See in Reactome
R-HSA-190388
(
R-HSA-190372
)
R-HSA-190388
Reaction Name: Autocatalytic phosphorylation of FGFR3c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654148
(
R-HSA-5654227
)
R-HSA-5654148
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR3
See in Reactome
R-HSA-5654222
(
R-HSA-5654227
)
R-HSA-5654222
Reaction Name: Activated FGFR3 phosphorylates PLCG1
See in Reactome
R-HSA-5654224
(
R-HSA-5654227
)
R-HSA-5654408
(
R-HSA-5654706
)
R-HSA-5654408
Reaction Name: Activated FGFR3 phosphorylates FRS2
See in Reactome
R-HSA-5654409
(
R-HSA-5654706
)
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654416
(
R-HSA-5654706
)
R-HSA-5654416
Reaction Name: Activated FGFR3:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654565
(
R-HSA-5654732
)
R-HSA-5654565
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2.
See in Reactome
R-HSA-5654623
(
R-HSA-5654706
)
R-HSA-5654625
(
R-HSA-5654704
)
R-HSA-5654628
(
R-HSA-5654706
)
R-HSA-5654628
Reaction Name: Activated FGFR3 phosphorylates FRS3
See in Reactome
R-HSA-5654631
(
R-HSA-5654706
)
R-HSA-5654631
Reaction Name: Activated FGFR3 phosphorylates PPTN11
See in Reactome
R-HSA-5654633
(
R-HSA-5654706
)
R-HSA-5654633
Reaction Name: Activated FGFR3:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654634
(
R-HSA-5654704
)
R-HSA-5654634
Reaction Name: Activated FGFR3 phosphorylates SHC1
See in Reactome
R-HSA-5654637
(
R-HSA-5654710
)
R-HSA-5654637
Reaction Name: Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654641
(
R-HSA-5654710
)
R-HSA-5654641
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654646
(
R-HSA-5654704
)
R-HSA-5654646
Reaction Name: Activated FGFR3:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654679
(
R-HSA-5654732
)
R-HSA-5654679
Reaction Name: CBL ubiquitinates FRS2 and FGFR3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654730
(
R-HSA-5654732
)
R-HSA-5654730
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0003669 |
KIT |
P10721 |
2.7.10.1
|
R-HSA-1433559
R-HSA-1257604
R-HSA-1433557
R-HSA-8866910
R-HSA-8866910
Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5673001
|
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-73857
R-HSA-5684996
R-HSA-162582
R-HSA-8864260
R-HSA-8864260
Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
See in Reactome
|
Gene expression (Transcription)
Signal Transduction
|
R-HSA-1433410
(
R-HSA-1433557;
R-HSA-1433559
)
R-HSA-1433410
Reaction Name: SOCS1 as a regulator of KIT signaling
See in Reactome
R-HSA-1433418
(
R-HSA-1433557
)
R-HSA-1433423
(
R-HSA-1433557
)
R-HSA-1433423
Reaction Name: PTP-RO interacts with p-c-Kit complex
See in Reactome
R-HSA-1433428
(
R-HSA-1433557
)
R-HSA-1433428
Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2
See in Reactome
R-HSA-1433451
(
R-HSA-1433557
)
R-HSA-1433454
(
R-HSA-1433557
)
R-HSA-1433454
Reaction Name: Phosphorylation of GAB2 by SFKs
See in Reactome
R-HSA-1433456
(
R-HSA-1433557
)
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-1433488
(
R-HSA-1433557
)
R-HSA-1433488
Reaction Name: Phosphorylation of SHP2 by SFKs
See in Reactome
R-HSA-1433501
(
R-HSA-1433557
)
R-HSA-1433501
Reaction Name: Interaction of other adapter proteins with p-KIT
See in Reactome
R-HSA-1433506
(
R-HSA-1433557;
R-HSA-1433559
)
R-HSA-1433508
(
R-HSA-1433557;
R-HSA-1433559
)
R-HSA-1433508
Reaction Name: PKC alpha interacts with and phosphorylates KIT
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1433542
(
R-HSA-1433557
)
R-HSA-1433542
Reaction Name: Phosphorylation and activation of VAV1
See in Reactome
R-HSA-1470009
(
R-HSA-1433557
)
R-HSA-1470010
(
R-HSA-1433557
)
R-HSA-1470011
(
R-HSA-1433557;
R-HSA-1433559
)
R-HSA-1470011
Reaction Name: Downregulation of c-Kit signaling by SOCS6
See in Reactome
R-HSA-1470012
(
R-HSA-1433557
)
R-HSA-1470012
Reaction Name: Disassociation and translocation of STATs to the nucleus
See in Reactome
R-HSA-1472121
(
R-HSA-1433557
)
R-HSA-1472121
Reaction Name: Phosphorylation of p-KIT on Y900 by Src kinases
See in Reactome
R-HSA-1562640
(
R-HSA-1433557;
R-HSA-1433559
)
R-HSA-1562640
Reaction Name: LNK binds to p-KIT and inhibit downstream signaling
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-205205
(
R-HSA-1433557
)
R-HSA-205205
Reaction Name: Interaction of Src family kinases with p-KIT
See in Reactome
R-HSA-205231
(
R-HSA-1433557
)
R-HSA-205231
Reaction Name: Dimerization of KIT upon SCF binding
See in Reactome
R-HSA-205234
(
R-HSA-1433557
)
R-HSA-205234
Reaction Name: Indirect recruitment of GAB2 to p-KIT
See in Reactome
R-HSA-205238
(
R-HSA-1433557
)
R-HSA-205244
(
R-HSA-1433557;
R-HSA-1433559
)
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-205286
(
R-HSA-1433557
)
R-HSA-205289
(
R-HSA-1433557
)
R-HSA-205306
(
R-HSA-1433557;
R-HSA-1433559
)
R-HSA-205319
(
R-HSA-1433557;
R-HSA-1433559
)
R-HSA-205321
(
R-HSA-1433557
)
R-HSA-205328
(
R-HSA-1433557
)
R-HSA-205328
Reaction Name: Interaction of other tyrosine kinases with p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8864698
(
R-HSA-8866910
)
R-HSA-8864698
Reaction Name: KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers
See in Reactome
R-HSA-9669854
(
R-HSA-1433557
)
R-HSA-9669893
(
R-HSA-1433557
)
R-HSA-9681375
(
R-HSA-1433557
)
|
MONDO:0003789 |
MET |
P08581 |
2.7.10.1
|
R-HSA-6806942
R-HSA-9022699
R-HSA-9022699
Reactome Name: MECP2 regulates neuronal receptors and channels
See in Reactome
R-HSA-1257604
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-6807004
R-HSA-6807004
Reactome Name: Negative regulation of MET activity
See in Reactome
R-HSA-8865999
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-8851805
R-HSA-8875513
R-HSA-8875513
Reactome Name: MET interacts with TNS proteins
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-8875555
R-HSA-8875791
R-HSA-8875656
R-HSA-8874081
R-HSA-9734091
R-HSA-9734091
Reactome Name: Drug-mediated inhibition of MET activation
See in Reactome
R-HSA-5673001
|
R-HSA-6806834
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-9675108
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-373755
R-HSA-422475
R-HSA-8875878
R-HSA-5684996
R-HSA-400685
R-HSA-1266738
R-HSA-73857
|
Gene expression (Transcription)
Signal Transduction
Developmental Biology
|
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-400677
(
R-HSA-416550
)
R-HSA-400677
Reaction Name: Rnd1 interacts with Plexin-B1:Sema4D
See in Reactome
R-HSA-400682
(
R-HSA-416550
)
R-HSA-400682
Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D
See in Reactome
R-HSA-416546
(
R-HSA-416550
)
R-HSA-416546
Reaction Name: Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416562
(
R-HSA-416550
)
R-HSA-419646
(
R-HSA-416550
)
R-HSA-419646
Reaction Name: SEMA4D interacts with Plexin-B1:Met
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-6800298
(
R-HSA-6806942
)
R-HSA-6806957
(
R-HSA-6806942
)
R-HSA-6806974
(
R-HSA-6806942
)
R-HSA-6807008
(
R-HSA-6807004
)
R-HSA-6807027
(
R-HSA-6807004
)
R-HSA-6807027
Reaction Name: PTPN1 and PTPN2 dephosphorylate MET
See in Reactome
R-HSA-8851804
(
R-HSA-8851805
)
R-HSA-8851804
Reaction Name: Activated MET recruits GRB2-1:SOS1
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851842
(
R-HSA-8851805
)
R-HSA-8851842
Reaction Name: MUC20 binds MET and inhibits GRB2 binding
See in Reactome
R-HSA-8851859
(
R-HSA-8851805
)
R-HSA-8851859
Reaction Name: Activated MET binds RANBP9 and SOS1
See in Reactome
R-HSA-8851866
(
R-HSA-8851805
)
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851888
(
R-HSA-8851805
)
R-HSA-8851890
(
R-HSA-8851805
)
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8851900
(
R-HSA-8851805
)
R-HSA-8851900
Reaction Name: SHC1-2 bound to MET recruits GRB2:SOS1
See in Reactome
R-HSA-8851908
(
R-HSA-8851907
)
R-HSA-8851919
(
R-HSA-8851907
)
R-HSA-8851919
Reaction Name: Activated MET binds GAB1 and GRB2
See in Reactome
R-HSA-8851933
(
R-HSA-8851907
)
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8865994
(
R-HSA-8865999
)
R-HSA-8874078
(
R-HSA-8874081
)
R-HSA-8874079
(
R-HSA-8874081
)
R-HSA-8874080
(
R-HSA-8874081
)
R-HSA-8874082
(
R-HSA-8874081
)
R-HSA-8874083
(
R-HSA-8874081
)
R-HSA-8874685
(
R-HSA-6807004
)
R-HSA-8875183
(
R-HSA-6807004
)
R-HSA-8875183
Reaction Name: CBL monoubiquitinates activated MET
See in Reactome
R-HSA-8875374
(
R-HSA-6807004
)
R-HSA-8875431
(
R-HSA-6807004
)
R-HSA-8875431
Reaction Name: LRIG1 undergoes ubiquitination
See in Reactome
R-HSA-8875443
(
R-HSA-6807004
)
R-HSA-8875451
(
R-HSA-6807004
)
R-HSA-8875482
(
R-HSA-6807004
)
R-HSA-8875482
Reaction Name: CBL recruits CIN85:endophilin to ubiquitinated MET
See in Reactome
R-HSA-8875490
(
R-HSA-6807004
)
R-HSA-8875490
Reaction Name: EPS15 and HGS bind ubiquitinated MET
See in Reactome
R-HSA-8875523
(
R-HSA-8875513
)
R-HSA-8875531
(
R-HSA-8875513
)
R-HSA-8875540
(
R-HSA-8875555
)
R-HSA-8875558
(
R-HSA-8875555
)
R-HSA-8875568
(
R-HSA-8875555
)
R-HSA-8875576
(
R-HSA-8875555
)
R-HSA-8875576
Reaction Name: CRK,CRKL recruits RAC1 GEF to activated MET
See in Reactome
R-HSA-8875591
(
R-HSA-8875555
)
R-HSA-8875659
(
R-HSA-8875656
)
R-HSA-8875659
Reaction Name: RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane
See in Reactome
R-HSA-8875661
(
R-HSA-8875656
)
R-HSA-8875661
Reaction Name: GGA3 associates with activated MET receptor
See in Reactome
R-HSA-8875816
(
R-HSA-8875791
)
R-HSA-8875816
Reaction Name: STAT3 binds activated MET receptor
See in Reactome
R-HSA-8875817
(
R-HSA-8875791
)
R-HSA-8986940
(
R-HSA-9022699
)
R-HSA-8986940
Reaction Name: MET gene transcription is stimulated by MECP2
See in Reactome
R-HSA-9734070
(
R-HSA-6807004;
R-HSA-9734091
)
R-HSA-9734070
Reaction Name: Anti-MET recombinant therapeutic antibodies bind MET
See in Reactome
R-HSA-9735946
(
R-HSA-6807004;
R-HSA-9734091
)
R-HSA-9735946
Reaction Name: Anti-MET small tyrosine kinase inhibitors bind MET
See in Reactome
|
MONDO:0005012 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0005029 |
JAK2 |
O60674 |
2.7.10.2
|
R-HSA-8984722
R-HSA-2586552
R-HSA-9020956
R-HSA-9020933
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-9027277
R-HSA-9027277
Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG)
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-982772
R-HSA-982772
Reactome Name: Growth hormone receptor signaling
See in Reactome
R-HSA-6788467
R-HSA-6788467
Reactome Name: IL-6-type cytokine receptor ligand interactions
See in Reactome
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-877300
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-9006335
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-9027283
R-HSA-9027283
Reactome Name: Erythropoietin activates STAT5
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9020591
R-HSA-1059683
R-HSA-9674555
R-HSA-1170546
R-HSA-112411
R-HSA-877312
R-HSA-3214858
R-HSA-3214858
Reactome Name: RMTs methylate histone arginines
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-9027284
|
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-449147
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-168256
R-HSA-451927
R-HSA-4839726
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-1640170
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-3247509
R-HSA-913531
R-HSA-5684996
R-HSA-109582
R-HSA-162582
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
|
Immune System
Chromatin organization
Cell Cycle
Hemostasis
Signal Transduction
|
R-HSA-1168456
(
R-HSA-982772
)
R-HSA-1168456
Reaction Name: Growth hormone receptor binds Lyn
See in Reactome
R-HSA-8983870
(
R-HSA-8984722
)
R-HSA-8983870
Reaction Name: JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated
See in Reactome
R-HSA-2671862
(
R-HSA-2586552
)
R-HSA-2671862
Reaction Name: JAK2 Phosphorylates IRS in Response to Leptin
See in Reactome
R-HSA-6786070
(
R-HSA-6785807
)
R-HSA-6786070
Reaction Name: IL4:IL4R:JAK2 binds IL13RA1:TYK2
See in Reactome
R-HSA-1067688
(
R-HSA-1059683
)
R-HSA-1067688
Reaction Name: IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950737
(
R-HSA-9020933
)
R-HSA-448427
(
R-HSA-9020956
)
R-HSA-448427
Reaction Name: Interleukin-27 binds Interleukin-27 receptor
See in Reactome
R-HSA-1433418
(
R-HSA-1433557
)
R-HSA-8950423
(
R-HSA-9020591
)
R-HSA-8950423
Reaction Name: JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated
See in Reactome
R-HSA-873922
(
R-HSA-877300
)
R-HSA-873922
Reaction Name: Phosphorylation of STAT1 by JAK kinases
See in Reactome
R-HSA-2586555
(
R-HSA-2586552
)
R-HSA-2586555
Reaction Name: JAK2 Autophosphorylates in Response to Leptin
See in Reactome
R-HSA-1370500
(
R-HSA-1170546
)
R-HSA-1370500
Reaction Name: PRLR binds SCF beta-TrCP complex
See in Reactome
R-HSA-8987104
(
R-HSA-8854691
)
R-HSA-8987104
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3
See in Reactome
R-HSA-1169192
(
R-HSA-982772
)
R-HSA-1168459
(
R-HSA-982772
)
R-HSA-6786096
(
R-HSA-6785807
)
R-HSA-6786096
Reaction Name: IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated
See in Reactome
R-HSA-9012651
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012651
Reaction Name: p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-1433456
(
R-HSA-1433557
)
R-HSA-6785898
(
R-HSA-6785807
)
R-HSA-877308
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-2672302
(
R-HSA-2586552
)
R-HSA-2672302
Reaction Name: Phosphorylated LEPR Binds SOCS3
See in Reactome
R-HSA-873924
(
R-HSA-877300
)
R-HSA-873924
Reaction Name: Phosphorylation of IFNGR1 by JAK kinases
See in Reactome
R-HSA-8950063
(
R-HSA-9020591
)
R-HSA-921155
(
R-HSA-512988
)
R-HSA-921155
Reaction Name: p-STAT5 dissociates from the receptor complex
See in Reactome
R-HSA-9027274
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9027274
Reaction Name: EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1
See in Reactome
R-HSA-109858
(
R-HSA-112411
)
R-HSA-6783552
(
R-HSA-6788467
)
R-HSA-6786110
(
R-HSA-6785807
)
R-HSA-6786110
Reaction Name: JAK1 binds IL4R in IL13-bound IL13R type II
See in Reactome
R-HSA-2586553
(
R-HSA-2586552
)
R-HSA-1112514
(
R-HSA-1059683
)
R-HSA-9006332
(
R-HSA-9006335
)
R-HSA-9006332
Reaction Name: JAK2 transphosphorylates and is activated in response to Erythropoietin
See in Reactome
R-HSA-879925
(
R-HSA-512988
)
R-HSA-879925
Reaction Name: SHC1 bound to the common beta chain becomes tyrosine phosphorylated
See in Reactome
R-HSA-2671855
(
R-HSA-2586552
)
R-HSA-2671855
Reaction Name: Phosphorylated LEPR Binds STAT5
See in Reactome
R-HSA-1169210
(
R-HSA-982772
)
R-HSA-9027281
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027281
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1
See in Reactome
R-HSA-1112510
(
R-HSA-1059683
)
R-HSA-1112510
Reaction Name: IL6ST is tyrosine phosphorylated
See in Reactome
R-HSA-447226
(
R-HSA-9020591
)
R-HSA-447226
Reaction Name: Interleukin-12 binds Interleukin-12 receptor
See in Reactome
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-9012654
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012654
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5
See in Reactome
R-HSA-8950354
(
R-HSA-9020591
)
R-HSA-8950354
Reaction Name: STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction
See in Reactome
R-HSA-8950583
(
R-HSA-9020933
)
R-HSA-8950583
Reaction Name: STAT3 binds to p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-8950210
(
R-HSA-9020956
)
R-HSA-8950210
Reaction Name: Interleukin-27 dissociates from Interleukin-27 receptor
See in Reactome
R-HSA-9027280
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-1370505
(
R-HSA-1170546
)
R-HSA-1370505
Reaction Name: PRLR is phosphorylated at Ser-349
See in Reactome
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-8983876
(
R-HSA-8984722
)
R-HSA-6783530
(
R-HSA-6788467
)
R-HSA-8950364
(
R-HSA-9020933
)
R-HSA-8950364
Reaction Name: IL23R in IL23:IL23 receptor complex is phosphorylated
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-1470010
(
R-HSA-1433557
)
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-8950128
(
R-HSA-9020591
)
R-HSA-8950128
Reaction Name: Interleukin-12 dissociates from Interleukin-12 receptor
See in Reactome
R-HSA-879907
(
R-HSA-512988
)
R-HSA-879907
Reaction Name: Tyrosine kinases phosphorylate the receptor
See in Reactome
R-HSA-1168423
(
R-HSA-982772
)
R-HSA-1168423
Reaction Name: JAK2 phosphorylation of IRS-1/2
See in Reactome
R-HSA-1168768
(
R-HSA-982772
)
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-2671829
(
R-HSA-2586552
)
R-HSA-2671829
Reaction Name: JAK2 Phosphorylates STAT5 in Response to Leptin
See in Reactome
R-HSA-6783681
(
R-HSA-6788467
)
R-HSA-8987220
(
R-HSA-8854691
)
R-HSA-8987220
Reaction Name: IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3
See in Reactome
R-HSA-8984014
(
R-HSA-8984722
)
R-HSA-8984014
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3
See in Reactome
R-HSA-976991
(
R-HSA-1170546
)
R-HSA-976991
Reaction Name: Prolactin receptor ligands bind the prolactin receptor
See in Reactome
R-HSA-1671687
(
R-HSA-1170546
)
R-HSA-9032478
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9032478
Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate
See in Reactome
R-HSA-1470012
(
R-HSA-1433557
)
R-HSA-1470012
Reaction Name: Disassociation and translocation of STATs to the nucleus
See in Reactome
R-HSA-6786124
(
R-HSA-6785807
)
R-HSA-9006325
(
R-HSA-9006335
)
R-HSA-9029158
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-982792
(
R-HSA-982772
)
R-HSA-982792
Reaction Name: Growth hormone receptor binds JAK2
See in Reactome
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-9027425
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027425
Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2
See in Reactome
R-HSA-9024723
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024723
Reaction Name: EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1
See in Reactome
R-HSA-879930
(
R-HSA-512988
)
R-HSA-873918
(
R-HSA-877300
)
R-HSA-1169188
(
R-HSA-982772
)
R-HSA-1169188
Reaction Name: SHP1 (PTPN6) dephosphorylates JAK2
See in Reactome
R-HSA-8950518
(
R-HSA-9020956
)
R-HSA-8950518
Reaction Name: STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex
See in Reactome
R-HSA-8983841
(
R-HSA-8984722
)
R-HSA-8983841
Reaction Name: STAT1 associates with IL6ST:IL6ST
See in Reactome
R-HSA-879910
(
R-HSA-512988
)
R-HSA-879910
Reaction Name: JAK2 is phosphorylated, activated
See in Reactome
R-HSA-8950757
(
R-HSA-9020591
)
R-HSA-8950757
Reaction Name: IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated
See in Reactome
R-HSA-2671876
(
R-HSA-2586552
)
R-HSA-2671876
Reaction Name: Phosphorylated STAT5 Dissociates from Leptin Receptor
See in Reactome
R-HSA-2671868
(
R-HSA-2586552
)
R-HSA-2671868
Reaction Name: Phosphorylated LEPR Binds STAT3
See in Reactome
R-HSA-877269
(
R-HSA-877300;
R-HSA-877312
)
R-HSA-877269
Reaction Name: SOCS-1 and SOCS-3 binds to p-JAK2
See in Reactome
R-HSA-8983834
(
R-HSA-8984722
)
R-HSA-8983834
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated
See in Reactome
R-HSA-879934
(
R-HSA-512988
)
R-HSA-879934
Reaction Name: Recruitment of SHC1 is mediated by Y593 of the common beta chain
See in Reactome
R-HSA-6786114
(
R-HSA-6785807
)
R-HSA-6786114
Reaction Name: IL13:IL13RA:TYK2 binds IL4R:JAK2
See in Reactome
R-HSA-913451
(
R-HSA-512988
)
R-HSA-913451
Reaction Name: IL3RB is phosphorylated on Ser-585
See in Reactome
R-HSA-6783556
(
R-HSA-6788467
)
R-HSA-6783556
Reaction Name: LIFR:JAKs bind gp130:JAKs:CNTFR
See in Reactome
R-HSA-8983519
(
R-HSA-8984722
)
R-HSA-8983519
Reaction Name: IL35 binds IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-913370
(
R-HSA-512988
)
R-HSA-913370
Reaction Name: Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2
See in Reactome
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-2671873
(
R-HSA-2586552
)
R-HSA-2671873
Reaction Name: Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2
See in Reactome
R-HSA-8983518
(
R-HSA-8984722
)
R-HSA-8983518
Reaction Name: IL35 binds IL6ST:IL6ST receptor
See in Reactome
R-HSA-3215391
(
R-HSA-3214858
)
R-HSA-3215391
Reaction Name: PRMT5 is tyrosine phosphorylated by JAK2 V617F
See in Reactome
R-HSA-5696482
(
R-HSA-6788467
)
R-HSA-1369080
(
R-HSA-1170546
)
R-HSA-1364044
(
R-HSA-1170546
)
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-1112727
(
R-HSA-1059683
)
R-HSA-1112727
Reaction Name: Serine phosphorylation of STATs
See in Reactome
R-HSA-9027275
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-1433451
(
R-HSA-1433557
)
R-HSA-8950441
(
R-HSA-9020956
)
R-HSA-8950441
Reaction Name: p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor
See in Reactome
R-HSA-8950269
(
R-HSA-9020933
)
R-HSA-8950269
Reaction Name: STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor
See in Reactome
R-HSA-879942
(
R-HSA-512988
)
R-HSA-8952823
(
R-HSA-9020933
)
R-HSA-8952823
Reaction Name: p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor
See in Reactome
R-HSA-912757
(
R-HSA-512988
)
R-HSA-912757
Reaction Name: p-S585-IL3RB binds 14-3-3 proteins
See in Reactome
R-HSA-449976
(
R-HSA-6788467
)
R-HSA-449976
Reaction Name: IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)
See in Reactome
R-HSA-8950448
(
R-HSA-9020591
)
R-HSA-8950448
Reaction Name: STAT4 binds to IL12RB2 in Interleukin-12 receptor complex
See in Reactome
R-HSA-1112565
(
R-HSA-1059683
)
R-HSA-1112565
Reaction Name: Tyrosine phosphorylated IL6ST binds STAT1,STAT3
See in Reactome
R-HSA-2671839
(
R-HSA-2586552
)
R-HSA-2671839
Reaction Name: Phosphorylated STAT3 Dissociates from Leptin Receptor
See in Reactome
R-HSA-1067646
(
R-HSA-1059683;
R-HSA-9020956
)
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9027273
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027273
Reaction Name: JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1
See in Reactome
R-HSA-1112604
(
R-HSA-1059683
)
R-HSA-1112604
Reaction Name: Phosphorylated STATs are released
See in Reactome
R-HSA-8984023
(
R-HSA-8984722
)
R-HSA-8984023
Reaction Name: p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-982810
(
R-HSA-1170546;
R-HSA-982772
)
R-HSA-9678561
(
R-HSA-877300
)
R-HSA-9678561
Reaction Name: IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors
See in Reactome
R-HSA-8942607
(
R-HSA-69231
)
R-HSA-8942607
Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
See in Reactome
R-HSA-8981093
(
R-HSA-9020591
)
R-HSA-8981093
Reaction Name: IL12 bound to IL12R internalises
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-6786050
(
R-HSA-6785807
)
R-HSA-6786050
Reaction Name: IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated
See in Reactome
R-HSA-1671691
(
R-HSA-1170546
)
R-HSA-1671691
Reaction Name: PRLR-bound STAT5 is phosphorylated
See in Reactome
R-HSA-447130
(
R-HSA-9020933
)
R-HSA-447130
Reaction Name: Interleukin-23 binds interleukin-23 receptor
See in Reactome
R-HSA-879937
(
R-HSA-512988
)
R-HSA-879937
Reaction Name: The common beta chain IL3RB binds JAK2
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-6785821
(
R-HSA-6785807
)
R-HSA-9024726
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9024726
Reaction Name: LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1
See in Reactome
R-HSA-8984021
(
R-HSA-8984722
)
R-HSA-8984021
Reaction Name: STAT1,STAT3 associate with IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-6809140
(
R-HSA-8984722
)
R-HSA-6809140
Reaction Name: IL35 binds IL-12RB2:IL6ST receptor
See in Reactome
R-HSA-1067651
(
R-HSA-1059683
)
R-HSA-1067651
Reaction Name: IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
See in Reactome
R-HSA-9029149
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029149
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-9006323
(
R-HSA-9006335
)
R-HSA-9006323
Reaction Name: Phospho-JAK2 phosphorylates EPOR
See in Reactome
R-HSA-6783524
(
R-HSA-6788467
)
R-HSA-6783524
Reaction Name: OSM,LIF,CTF1 receptor complex binds gp130
See in Reactome
R-HSA-997237
(
R-HSA-983231
)
R-HSA-912527
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-912527
Reaction Name: SHC1 mediates cytokine-induced phosphorylation of GAB2
See in Reactome
R-HSA-6788582
(
R-HSA-6785807
)
R-HSA-6788582
Reaction Name: STAT1,STAT3,STAT6 phosphorylation
See in Reactome
R-HSA-982778
(
R-HSA-982772
)
R-HSA-982778
Reaction Name: Growth hormone binds the growth hormone receptor
See in Reactome
R-HSA-1112755
(
R-HSA-1059683
)
R-HSA-109857
(
R-HSA-110056
)
R-HSA-1170539
(
R-HSA-1170546
)
R-HSA-1170539
Reaction Name: Prolactin receptor is internalized
See in Reactome
R-HSA-9012650
(
R-HSA-9006335;
R-HSA-9027283
)
R-HSA-9012650
Reaction Name: JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
See in Reactome
R-HSA-913424
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913424
Reaction Name: The SHC1:SHIP1 complex is stabilized by GRB2
See in Reactome
R-HSA-873921
(
R-HSA-877300
)
R-HSA-6786058
(
R-HSA-6785807
)
R-HSA-6786058
Reaction Name: JAK1 binds IL4R in IL4-bound IL4R1
See in Reactome
R-HSA-8950405
(
R-HSA-8984722
)
R-HSA-8950405
Reaction Name: JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-8952807
(
R-HSA-9020591
)
R-HSA-8952807
Reaction Name: p-Y693-STAT4 dissociates after IL12:IL12R interaction
See in Reactome
R-HSA-6786092
(
R-HSA-6785807
)
R-HSA-6786092
Reaction Name: IL4:IL4R:JAK2 binds IL2RG:JAK3
See in Reactome
R-HSA-6784189
(
R-HSA-6788467
)
R-HSA-879909
(
R-HSA-512988
)
R-HSA-6784204
(
R-HSA-6788467
)
R-HSA-1470009
(
R-HSA-1433557
)
R-HSA-450031
(
R-HSA-512988
)
R-HSA-450031
Reaction Name: Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2
See in Reactome
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-8950591
(
R-HSA-9020933
)
R-HSA-8950591
Reaction Name: JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated
See in Reactome
R-HSA-9021627
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-913371
(
R-HSA-512988
)
R-HSA-913371
Reaction Name: GM-CSF receptor alpha:GM-CSF binds Bc
See in Reactome
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-1168894
(
R-HSA-982772
)
R-HSA-1168894
Reaction Name: p-STAT5A/B dissociates from the Growth Hormone receptor
See in Reactome
R-HSA-8983996
(
R-HSA-8984722
)
R-HSA-8983996
Reaction Name: STAT1 and STAT4 associate with IL12RB2:IL6ST receptor
See in Reactome
R-HSA-8950537
(
R-HSA-9020956
)
R-HSA-8950537
Reaction Name: JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated
See in Reactome
R-HSA-6786072
(
R-HSA-6785807
)
R-HSA-6786072
Reaction Name: p-Y705-STAT3,p-Y641-STAT6 dissociate
See in Reactome
R-HSA-2586559
(
R-HSA-2586552
)
R-HSA-8987141
(
R-HSA-8854691
)
R-HSA-8987141
Reaction Name: IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8950453
(
R-HSA-8984722
)
R-HSA-8950453
Reaction Name: JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4
See in Reactome
R-HSA-873927
(
R-HSA-877300
)
R-HSA-873927
Reaction Name: Release of STAT1 dimer from active receptor unit
See in Reactome
R-HSA-453104
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453104
Reaction Name: Phosphorylated SHC1 recruits GRB2:GAB2
See in Reactome
R-HSA-913374
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-913374
Reaction Name: Phosphorylated SHC1 recruits SHIP
See in Reactome
R-HSA-6786101
(
R-HSA-6785807
)
R-HSA-1168839
(
R-HSA-982772
)
R-HSA-1168839
Reaction Name: SHP1 (PTPN6) binds JAK2 in the receptor complex
See in Reactome
R-HSA-8950485
(
R-HSA-9020956
)
R-HSA-8950485
Reaction Name: STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction
See in Reactome
R-HSA-6788628
(
R-HSA-6785807
)
R-HSA-8983878
(
R-HSA-8984722
)
R-HSA-8983878
Reaction Name: p-STAT4 dissociates from IL12RB2:IL12RB2 receptor
See in Reactome
R-HSA-873919
(
R-HSA-877300
)
R-HSA-8983983
(
R-HSA-8984722
)
R-HSA-8983983
Reaction Name: p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor
See in Reactome
R-HSA-2671850
(
R-HSA-2586552
)
R-HSA-2671850
Reaction Name: JAK2 Phosphoryates STAT3 in Response to Leptin
See in Reactome
R-HSA-8950340
(
R-HSA-9020956
)
R-HSA-8950340
Reaction Name: IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation
See in Reactome
R-HSA-1168767
(
R-HSA-982772
)
R-HSA-1168767
Reaction Name: JAK2 phosphorylates STAT1/STAT3
See in Reactome
R-HSA-9029151
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029151
Reaction Name: JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1
See in Reactome
R-HSA-447252
(
R-HSA-9020591
)
R-HSA-447252
Reaction Name: IL12RB1:TYK2 binds IL12RB2:JAK2
See in Reactome
R-HSA-1168394
(
R-HSA-982772
)
R-HSA-1168394
Reaction Name: STAT5 tyrosine phosphorylation
See in Reactome
R-HSA-1168393
(
R-HSA-982772
)
R-HSA-9029155
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029155
Reaction Name: JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1
See in Reactome
R-HSA-909552
(
R-HSA-877300
)
R-HSA-909552
Reaction Name: Phosphorylation of STAT1 at Ser727
See in Reactome
R-HSA-8952749
(
R-HSA-9020933
)
R-HSA-8952749
Reaction Name: STAT4 binds p-Y-IL23R in IL23:IL23 receptor
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-1302698
(
R-HSA-1170546
)
R-HSA-8983835
(
R-HSA-8984722
)
R-HSA-8983835
Reaction Name: JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1
See in Reactome
R-HSA-1067659
(
R-HSA-1059683
)
R-HSA-1067659
Reaction Name: Assembly of hexameric IL-6 receptor
See in Reactome
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-8983845
(
R-HSA-8984722
)
R-HSA-8983845
Reaction Name: p-STAT1 dissociates from IL6ST:IL6ST
See in Reactome
R-HSA-1675473
(
R-HSA-1170546
)
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-1168445
(
R-HSA-982772
)
R-HSA-1168445
Reaction Name: PTP1B binds the GH receptor complex
See in Reactome
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1364043
(
R-HSA-1170546
)
R-HSA-1364043
Reaction Name: Tyrosine phosphorylation of PRLR
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-1112602
(
R-HSA-1059683
)
R-HSA-1112602
Reaction Name: Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
See in Reactome
R-HSA-9027373
(
R-HSA-9006335;
R-HSA-9027277
)
R-HSA-9027373
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma
See in Reactome
R-HSA-8983872
(
R-HSA-8984722
)
R-HSA-8983872
Reaction Name: JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4
See in Reactome
R-HSA-8984001
(
R-HSA-8984722
)
R-HSA-8984001
Reaction Name: IL35 binds IL27RA:IL12RB2 receptor
See in Reactome
R-HSA-9029150
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029150
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1
See in Reactome
R-HSA-873926
(
R-HSA-877300
)
R-HSA-1168809
(
R-HSA-982772
)
R-HSA-8987179
(
R-HSA-8854691
)
R-HSA-8987179
Reaction Name: IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3
See in Reactome
R-HSA-2671872
(
R-HSA-2586552
)
R-HSA-2671872
Reaction Name: Phosphorylated LEP:LEPR:JAK2 Binds SH2B1
See in Reactome
R-HSA-982807
(
R-HSA-982772
)
R-HSA-9012657
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-453111
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-453111
Reaction Name: Phosphorylated SHC recruits GRB2:SOS1
See in Reactome
R-HSA-982775
(
R-HSA-982772
)
R-HSA-982775
Reaction Name: Growth hormone receptor dimerizes
See in Reactome
R-HSA-6786095
(
R-HSA-6785807
)
R-HSA-6786095
Reaction Name: JAK1 phosphorylates STAT3,STAT6
See in Reactome
R-HSA-8987156
(
R-HSA-8854691
)
R-HSA-8987156
Reaction Name: p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3
See in Reactome
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-982768
(
R-HSA-982772
)
R-HSA-982768
Reaction Name: GH:GHR:JAK2 complex undergoes a conformational change
See in Reactome
R-HSA-9027272
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027272
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2
See in Reactome
R-HSA-8984012
(
R-HSA-8984722
)
R-HSA-8984012
Reaction Name: JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated
See in Reactome
R-HSA-6788571
(
R-HSA-6785807
)
R-HSA-6788571
Reaction Name: STAT1,STAT3,STAT6 bind IL13:IL13R type II
See in Reactome
R-HSA-1168813
(
R-HSA-982772
)
|
MONDO:0005036 |
FGFR2 |
P21802 |
2.7.10.1
|
R-HSA-5654221
R-HSA-5654221
Reactome Name: Phospholipase C-mediated cascade; FGFR2
See in Reactome
R-HSA-190377
R-HSA-190377
Reactome Name: FGFR2b ligand binding and activation
See in Reactome
R-HSA-190375
R-HSA-190375
Reactome Name: FGFR2c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-109704
R-HSA-5654700
R-HSA-5654699
R-HSA-5654695
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5654738
R-HSA-74752
R-HSA-190241
R-HSA-190241
Reactome Name: FGFR2 ligand binding and activation
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-190236
R-HSA-5684996
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399;
R-HSA-74751
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190258
(
R-HSA-190375
)
R-HSA-190260
(
R-HSA-190377
)
R-HSA-190408
(
R-HSA-190377
)
R-HSA-190408
Reaction Name: Autocatalytic phosphorylation of FGFR2b
See in Reactome
R-HSA-190413
(
R-HSA-190375
)
R-HSA-190413
Reaction Name: Autocatalytic phosphorylation of FGFR2c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654147
(
R-HSA-5654221
)
R-HSA-5654147
Reaction Name: Activated FGFR2 phosphorylates PLCG1
See in Reactome
R-HSA-5654157
(
R-HSA-5654221
)
R-HSA-5654157
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR2
See in Reactome
R-HSA-5654159
(
R-HSA-5654221
)
R-HSA-5654397
(
R-HSA-5654700
)
R-HSA-5654397
Reaction Name: Activated FGFR2 phosphorylates FRS2
See in Reactome
R-HSA-5654399
(
R-HSA-5654700
)
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654404
(
R-HSA-5654699
)
R-HSA-5654406
(
R-HSA-5654699
)
R-HSA-5654406
Reaction Name: Activated FGFR2:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654407
(
R-HSA-5654699
)
R-HSA-5654407
Reaction Name: Activated FGFR2 phosphorylates SHC1
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654603
(
R-HSA-5654700
)
R-HSA-5654605
(
R-HSA-5654700
)
R-HSA-5654605
Reaction Name: Activated FGFR2 phosphorylates FRS3
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654612
(
R-HSA-5654695
)
R-HSA-5654612
Reaction Name: Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654615
(
R-HSA-5654700
)
R-HSA-5654615
Reaction Name: Activated FGFR2:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0005061 |
FGFR2 |
P21802 |
2.7.10.1
|
R-HSA-5654221
R-HSA-5654221
Reactome Name: Phospholipase C-mediated cascade; FGFR2
See in Reactome
R-HSA-190377
R-HSA-190377
Reactome Name: FGFR2b ligand binding and activation
See in Reactome
R-HSA-190375
R-HSA-190375
Reactome Name: FGFR2c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-109704
R-HSA-5654700
R-HSA-5654699
R-HSA-5654695
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5654738
R-HSA-74752
R-HSA-190241
R-HSA-190241
Reactome Name: FGFR2 ligand binding and activation
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-190236
R-HSA-5684996
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399;
R-HSA-74751
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190258
(
R-HSA-190375
)
R-HSA-190260
(
R-HSA-190377
)
R-HSA-190408
(
R-HSA-190377
)
R-HSA-190408
Reaction Name: Autocatalytic phosphorylation of FGFR2b
See in Reactome
R-HSA-190413
(
R-HSA-190375
)
R-HSA-190413
Reaction Name: Autocatalytic phosphorylation of FGFR2c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654147
(
R-HSA-5654221
)
R-HSA-5654147
Reaction Name: Activated FGFR2 phosphorylates PLCG1
See in Reactome
R-HSA-5654157
(
R-HSA-5654221
)
R-HSA-5654157
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR2
See in Reactome
R-HSA-5654159
(
R-HSA-5654221
)
R-HSA-5654397
(
R-HSA-5654700
)
R-HSA-5654397
Reaction Name: Activated FGFR2 phosphorylates FRS2
See in Reactome
R-HSA-5654399
(
R-HSA-5654700
)
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654404
(
R-HSA-5654699
)
R-HSA-5654406
(
R-HSA-5654699
)
R-HSA-5654406
Reaction Name: Activated FGFR2:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654407
(
R-HSA-5654699
)
R-HSA-5654407
Reaction Name: Activated FGFR2 phosphorylates SHC1
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654603
(
R-HSA-5654700
)
R-HSA-5654605
(
R-HSA-5654700
)
R-HSA-5654605
Reaction Name: Activated FGFR2 phosphorylates FRS3
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654612
(
R-HSA-5654695
)
R-HSA-5654612
Reaction Name: Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654615
(
R-HSA-5654700
)
R-HSA-5654615
Reaction Name: Activated FGFR2:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0005097 |
EGFR |
P00533 |
2.7.10.1
|
R-HSA-445144
R-HSA-1251932
R-HSA-1251932
Reactome Name: PLCG1 events in ERBB2 signaling
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-180292
R-HSA-1236394
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-5673001
R-HSA-9013507
R-HSA-9013507
Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus
See in Reactome
R-HSA-1257604
R-HSA-177929
R-HSA-8857538
R-HSA-8857538
Reactome Name: PTK6 promotes HIF1A stabilization
See in Reactome
R-HSA-8856828
R-HSA-8856825
R-HSA-8856825
Reactome Name: Cargo recognition for clathrin-mediated endocytosis
See in Reactome
R-HSA-1227986
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-180336
R-HSA-8847993
R-HSA-8847993
Reactome Name: ERBB2 Activates PTK6 Signaling
See in Reactome
R-HSA-212718
R-HSA-212718
Reactome Name: EGFR interacts with phospholipase C-gamma
See in Reactome
R-HSA-182971
R-HSA-179812
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-8866910
R-HSA-8866910
Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-6785631
|
R-HSA-9012852
R-HSA-157118
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-8848021
R-HSA-5684996
R-HSA-1266738
R-HSA-73857
R-HSA-8864260
R-HSA-8864260
Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5653656
R-HSA-373760
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-372790
R-HSA-416476
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-162582
|
Developmental Biology
Gene expression (Transcription)
Vesicle-mediated transport
Signal Transduction
|
R-HSA-1250195
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250195
Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers
See in Reactome
R-HSA-1250463
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250486
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250486
Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250488
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1250488
Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer
See in Reactome
R-HSA-1250498
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1251922
(
R-HSA-1227986;
R-HSA-1251932
)
R-HSA-1251922
Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2
See in Reactome
R-HSA-1251944
(
R-HSA-1227986;
R-HSA-1251932
)
R-HSA-1306957
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306963
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306963
Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-177922
(
R-HSA-177929
)
R-HSA-177923
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-177924
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177924
Reaction Name: Dephosphorylation of Gab1 by SHP2
See in Reactome
R-HSA-177925
(
R-HSA-177929;
R-HSA-180336
)
R-HSA-177925
Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex
See in Reactome
R-HSA-177926
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177926
Reaction Name: Dephosphorylation of PAG by SHP2
See in Reactome
R-HSA-177927
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177930
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177930
Reaction Name: GAB1 phosphorylation by EGFR kinase
See in Reactome
R-HSA-177933
(
R-HSA-177929;
R-HSA-180336
)
R-HSA-177933
Reaction Name: SHC1 phosphorylation by phosphorylated EGFR
See in Reactome
R-HSA-177934
(
R-HSA-177929
)
R-HSA-177935
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177935
Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR
See in Reactome
R-HSA-177936
(
R-HSA-177929;
R-HSA-180336
)
R-HSA-177936
Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR
See in Reactome
R-HSA-177937
(
R-HSA-177929
)
R-HSA-177937
Reaction Name: Phosphorylation of EGFR by SRC kinase
See in Reactome
R-HSA-177938
(
R-HSA-177929;
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177939
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-177941
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177941
Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR
See in Reactome
R-HSA-177942
(
R-HSA-177929
)
R-HSA-177943
(
R-HSA-177929;
R-HSA-179812
)
R-HSA-177943
Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex
See in Reactome
R-HSA-177944
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177944
Reaction Name: Activation of SHP2 through the binding to phospho-Gab1
See in Reactome
R-HSA-177945
(
R-HSA-177929;
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-182969
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-182969
Reaction Name: Phosphorylation of CBL (EGFR:CBL)
See in Reactome
R-HSA-182986
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-182986
Reaction Name: CBL-mediated ubiquitination of CIN85
See in Reactome
R-HSA-182990
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-182990
Reaction Name: Sprouty sequesters CBL away from active EGFR
See in Reactome
R-HSA-182993
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-182993
Reaction Name: Ubiquitination of stimulated EGFR (CBL)
See in Reactome
R-HSA-182994
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-182994
Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles
See in Reactome
R-HSA-183002
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183002
Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85
See in Reactome
R-HSA-183036
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183036
Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2)
See in Reactome
R-HSA-183051
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183055
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183058
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183058
Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL)
See in Reactome
R-HSA-183067
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183067
Reaction Name: Localization of CBL:GRB2 to the membrane
See in Reactome
R-HSA-183072
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183072
Reaction Name: EGFR non-clathrin mediated endocytosis
See in Reactome
R-HSA-183084
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183084
Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix
See in Reactome
R-HSA-183089
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183089
Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty
See in Reactome
R-HSA-1963563
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1963563
Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2
See in Reactome
R-HSA-1963578
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1963578
Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1963581
(
R-HSA-1227986
)
R-HSA-1963581
Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
See in Reactome
R-HSA-1963582
(
R-HSA-1227986
)
R-HSA-1963582
Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4
See in Reactome
R-HSA-1977959
(
R-HSA-1236394
)
R-HSA-1977959
Reaction Name: ERBB4 forms heterodimers with EGFR
See in Reactome
R-HSA-212706
(
R-HSA-177929;
R-HSA-212718
)
R-HSA-212706
Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor
See in Reactome
R-HSA-212710
(
R-HSA-177929;
R-HSA-212718
)
R-HSA-212710
Reaction Name: EGFR activates PLC-gamma1 by phosphorylation
See in Reactome
R-HSA-212713
(
R-HSA-177929;
R-HSA-212718
)
R-HSA-212713
Reaction Name: Active PLC-gamma1 dissociates from EGFR
See in Reactome
R-HSA-2179387
(
R-HSA-2179392;
R-HSA-416476;
R-HSA-881907
)
R-HSA-2179387
Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor
See in Reactome
R-HSA-2179407
(
R-HSA-2179392;
R-HSA-416476;
R-HSA-881907
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2179415
(
R-HSA-2179392;
R-HSA-416476;
R-HSA-881907
)
R-HSA-2179415
Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-445069
(
R-HSA-445144
)
R-HSA-445069
Reaction Name: L1-EGFR trans-heterodimerization
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-6785636
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-6785636
Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1
See in Reactome
R-HSA-6785648
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-8847995
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8847995
Reaction Name: Activated ERBB2 binds PTK6 (BRK)
See in Reactome
R-HSA-8848005
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8848005
Reaction Name: ERBB2 promotes PTK6 autophosphorylation
See in Reactome
R-HSA-8857549
(
R-HSA-8857538
)
R-HSA-8857549
Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB
See in Reactome
R-HSA-8857555
(
R-HSA-8857538
)
R-HSA-8857565
(
R-HSA-8857538
)
R-HSA-8857565
Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139
See in Reactome
R-HSA-8857577
(
R-HSA-8857538
)
R-HSA-8857577
Reaction Name: LINC01139 facilitates PTK6 autophosphorylation
See in Reactome
R-HSA-8857583
(
R-HSA-8857538
)
R-HSA-8857583
Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6
See in Reactome
R-HSA-8857925
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-8857925
Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307
See in Reactome
R-HSA-8863804
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8863804
Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
See in Reactome
R-HSA-8864029
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-8864029
Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172)
See in Reactome
R-HSA-8864105
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8864105
Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers
See in Reactome
R-HSA-8864125
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8864125
Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248
See in Reactome
R-HSA-8866279
(
R-HSA-8856825;
R-HSA-8856828
)
R-HSA-8866279
Reaction Name: Epsin family proteins bind ubiquitinated cargo
See in Reactome
R-HSA-8867041
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-8867044
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-8867044
Reaction Name: EGFR binds EPS15, EPN1, EPS15L1
See in Reactome
R-HSA-8867047
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-8867754
(
R-HSA-8856828
)
R-HSA-8867754
Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit
See in Reactome
R-HSA-8867756
(
R-HSA-8856828
)
R-HSA-8867756
Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
See in Reactome
R-HSA-8868071
(
R-HSA-8856828
)
R-HSA-8868072
(
R-HSA-8856828
)
R-HSA-8868072
Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
See in Reactome
R-HSA-8868230
(
R-HSA-8856828
)
R-HSA-8868230
Reaction Name: SNX9 recruits components of the actin polymerizing machinery
See in Reactome
R-HSA-8868236
(
R-HSA-8856828
)
R-HSA-8868236
Reaction Name: BAR domain proteins recruit dynamin
See in Reactome
R-HSA-8868648
(
R-HSA-8856828
)
R-HSA-8868648
Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P
See in Reactome
R-HSA-8868651
(
R-HSA-8856828
)
R-HSA-8868651
Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit
See in Reactome
R-HSA-8868658
(
R-HSA-8856828
)
R-HSA-8868658
Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
See in Reactome
R-HSA-8868659
(
R-HSA-8856828
)
R-HSA-8868659
Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle
See in Reactome
R-HSA-8868660
(
R-HSA-8856828
)
R-HSA-8868660
Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
See in Reactome
R-HSA-8868661
(
R-HSA-8856828
)
R-HSA-8868661
Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission
See in Reactome
R-HSA-8869438
(
R-HSA-8856828
)
R-HSA-8869438
Reaction Name: Dissociation of clathrin-associated proteins
See in Reactome
R-HSA-8871193
(
R-HSA-8856828
)
R-HSA-8871193
Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2
See in Reactome
R-HSA-8871194
(
R-HSA-8856828
)
R-HSA-8874797
(
R-HSA-8866910
)
R-HSA-8874797
Reaction Name: EGFR gene expression is stimulated by TFAP2C
See in Reactome
R-HSA-8951490
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-8951490
Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85
See in Reactome
R-HSA-9018572
(
R-HSA-9013507
)
R-HSA-9018573
(
R-HSA-9013507
)
R-HSA-9625465
(
R-HSA-8939211;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9625465
Reaction Name: E2-mediated FOS gene expression
See in Reactome
R-HSA-9625482
(
R-HSA-8939211;
R-HSA-9009391
)
R-HSA-9625487
(
R-HSA-8939211;
R-HSA-9009391
)
R-HSA-9625487
Reaction Name: PTK2 autophosphorylates downstream of EGFR
See in Reactome
R-HSA-9634702
(
R-HSA-8857538
)
R-HSA-9634702
Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2
See in Reactome
R-HSA-9674531
(
R-HSA-177929
)
|
MONDO:0005105 |
PDGFRA |
P16234 |
2.7.10.1
|
R-HSA-186797
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-186763
R-HSA-1257604
R-HSA-5673001
|
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-5684996
R-HSA-162582
|
Signal Transduction
|
R-HSA-1524182
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-1524182
Reaction Name: Activated PLC gamma dissociates from the PDGF receptor
See in Reactome
R-HSA-1524186
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-1524186
Reaction Name: Phosphorylation of PLCgamma by PDGFR
See in Reactome
R-HSA-186765
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-186765
Reaction Name: PLC-gamma binds to the active receptor
See in Reactome
R-HSA-186773
(
R-HSA-186797
)
R-HSA-186773
Reaction Name: PDGF dimer binds two receptors simultaneously
See in Reactome
R-HSA-186778
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-186778
Reaction Name: SHP2 binds to the active receptor
See in Reactome
R-HSA-186780
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-186819
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-186819
Reaction Name: SH2 domain of Src binds to the active receptor
See in Reactome
R-HSA-186826
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-186826
Reaction Name: GRB2:SOS1 complex binds to the active receptor
See in Reactome
R-HSA-186834
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-380780
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-380782
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-380782
Reaction Name: STAT binds to the active receptor
See in Reactome
R-HSA-382052
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-382052
Reaction Name: p130Cas and C3G bind PDGFR bound Crk
See in Reactome
R-HSA-382055
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-382055
Reaction Name: Grb7 binds to the active PDGF receptor
See in Reactome
R-HSA-382056
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-382056
Reaction Name: Crk binds to the active PDGF receptor
See in Reactome
R-HSA-382058
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-382058
Reaction Name: Nck binds to the active PDGF receptor
See in Reactome
R-HSA-389083
(
R-HSA-186797
)
R-HSA-389083
Reaction Name: Autophosphorylation of PDGF alpha receptors
See in Reactome
R-HSA-389086
(
R-HSA-186797
)
R-HSA-389086
Reaction Name: Autophosphorylation of PDGF alpha/beta receptors
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8864036
(
R-HSA-186797
)
R-HSA-8864036
Reaction Name: PTPN12 dephosphorylates PDGFRB at Y1021
See in Reactome
R-HSA-9674015
(
R-HSA-186797
)
R-HSA-9674093
(
R-HSA-186797
)
R-HSA-9674095
(
R-HSA-186797
)
|
MONDO:0005105 |
ERBB4 |
Q15303 |
2.7.10.1
|
R-HSA-9620244
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-1257604
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-6785631
R-HSA-9018519
R-HSA-9018519
Reactome Name: Estrogen-dependent gene expression
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-1227986
R-HSA-1236394
R-HSA-1253288
R-HSA-1253288
Reactome Name: Downregulation of ERBB4 signaling
See in Reactome
R-HSA-8847993
R-HSA-8847993
Reactome Name: ERBB2 Activates PTK6 Signaling
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1251985
R-HSA-5673001
|
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-8848021
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-8939211
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-112316
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5684996
R-HSA-162582
|
Neuronal System
Signal Transduction
|
R-HSA-1236398
(
R-HSA-1236394
)
R-HSA-1236398
Reaction Name: ERBB4 binds NRGs or EGF-like ligands
See in Reactome
R-HSA-1250195
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250195
Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers
See in Reactome
R-HSA-1250220
(
R-HSA-1236394
)
R-HSA-1250315
(
R-HSA-1236394
)
R-HSA-1250315
Reaction Name: Trans-autophosphorylation of ERBB4 homodimers
See in Reactome
R-HSA-1250346
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250348
(
R-HSA-1236394;
R-HSA-1250347
)
R-HSA-1250348
Reaction Name: Phosphorylation of SHC1 by ERBB4 homodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1236394;
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250357
(
R-HSA-1236394;
R-HSA-1250347
)
R-HSA-1250357
Reaction Name: SHC1 binds P-ERBB4 isoform dimers
See in Reactome
R-HSA-1250370
(
R-HSA-1236394;
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250380
(
R-HSA-1236394;
R-HSA-1250347
)
R-HSA-1250380
Reaction Name: Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers
See in Reactome
R-HSA-1250383
(
R-HSA-1236394;
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1236394;
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250486
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250486
Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1251992
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1251992
Reaction Name: Cleavage of P-ERBB4jmA isoforms by ADAM17
See in Reactome
R-HSA-1251997
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1251997
Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex
See in Reactome
R-HSA-1252013
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1252013
Reaction Name: Translocation of ERBB4s80 to the nucleus
See in Reactome
R-HSA-1253282
(
R-HSA-1236394;
R-HSA-1253288
)
R-HSA-1253282
Reaction Name: ERBB4 ubiquitination by WWP1/ITCH
See in Reactome
R-HSA-1253300
(
R-HSA-1236394;
R-HSA-1253288
)
R-HSA-1253300
Reaction Name: ERBB4 binds WWP1/ITCH ubiquitin ligases
See in Reactome
R-HSA-1253319
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1253319
Reaction Name: ERBB4s80:TAB2:NCOR1 complex translocates to the nucleus
See in Reactome
R-HSA-1253321
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1253321
Reaction Name: GFAP gene expression is inhibited by ERBB4:TAB2:NCOR1
See in Reactome
R-HSA-1253325
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1253325
Reaction Name: ERBB4s80 binds TAB2:NCOR1 complex
See in Reactome
R-HSA-1253343
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254248
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254248
Reaction Name: Translocation of ERBB4s80:YAP1 complex to the nucleus
See in Reactome
R-HSA-1254251
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254285
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254285
Reaction Name: ERBB4s80:STAT5A complex translocates to the nucleus
See in Reactome
R-HSA-1254290
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254290
Reaction Name: CSN2 gene expression is stimulated by ERBB4s80:STAT5A
See in Reactome
R-HSA-1254291
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254376
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254376
Reaction Name: Translocation of cytosolic ERBB4s80 to mitochondrial matrix
See in Reactome
R-HSA-1254386
(
R-HSA-1236394;
R-HSA-1251985;
R-HSA-9018519
)
R-HSA-1254386
Reaction Name: ERBB4s80 forms a complex with estrogen receptor ESR1
See in Reactome
R-HSA-1254392
(
R-HSA-1236394;
R-HSA-1251985;
R-HSA-9018519
)
R-HSA-1254392
Reaction Name: PGR gene expression is stimulated by ERBB4s80:ESR1:estrogen
See in Reactome
R-HSA-1306969
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1306969
Reaction Name: GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1306972
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1306979
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1963563
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1963563
Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2
See in Reactome
R-HSA-1963578
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1963578
Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1963581
(
R-HSA-1227986
)
R-HSA-1963581
Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
See in Reactome
R-HSA-1963582
(
R-HSA-1227986
)
R-HSA-1963582
Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4
See in Reactome
R-HSA-1973956
(
R-HSA-1236394;
R-HSA-1253288
)
R-HSA-1973956
Reaction Name: NEDD4 binds ERBB4jmAcyt1s80 dimer
See in Reactome
R-HSA-1977296
(
R-HSA-1236394;
R-HSA-1253288
)
R-HSA-1977296
Reaction Name: NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer
See in Reactome
R-HSA-1977958
(
R-HSA-1236394
)
R-HSA-1977958
Reaction Name: ERBB4 forms heterodimers with ERBB3
See in Reactome
R-HSA-1977959
(
R-HSA-1236394
)
R-HSA-1977959
Reaction Name: ERBB4 forms heterodimers with EGFR
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-6785636
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-6785636
Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1
See in Reactome
R-HSA-6785648
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-8847995
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8847995
Reaction Name: Activated ERBB2 binds PTK6 (BRK)
See in Reactome
R-HSA-8848005
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8848005
Reaction Name: ERBB2 promotes PTK6 autophosphorylation
See in Reactome
R-HSA-8863804
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8863804
Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
See in Reactome
R-HSA-8954179
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-8954179
Reaction Name: S100B gene expression is inhibited by ERBB4:TAB2:NCOR1
See in Reactome
R-HSA-8954182
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-8954182
Reaction Name: ERBB4s80:TAB2:NCOR1 complex binds S100B gene promoter
See in Reactome
R-HSA-8954185
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-8954185
Reaction Name: ERBB4s80:TAB2:NCOR1 complex binds GFAP gene promoter
See in Reactome
R-HSA-8954199
(
R-HSA-1236394;
R-HSA-1251985;
R-HSA-9018519
)
R-HSA-8954199
Reaction Name: CXCL12 gene expression is stimulated by ERBB4s80:ESR1:estrogen
See in Reactome
R-HSA-8954207
(
R-HSA-1236394;
R-HSA-1251985;
R-HSA-9018519
)
R-HSA-8954207
Reaction Name: ERBB4s80:ESR1 binds CXCL12 gene promoter
See in Reactome
R-HSA-8954208
(
R-HSA-1236394;
R-HSA-1251985;
R-HSA-9018519
)
R-HSA-8954208
Reaction Name: ERBB4s80:ESR1 binds PGR gene promoter
See in Reactome
R-HSA-8954224
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-8954224
Reaction Name: ERBB4s80:STAT5A binds CSN2 gene promoter
See in Reactome
R-HSA-9612085
(
R-HSA-9620244
)
R-HSA-9612085
Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs
See in Reactome
R-HSA-9612219
(
R-HSA-1236394;
R-HSA-1253288
)
R-HSA-9612243
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612243
Reaction Name: APOE gene transcription is stimulated by ERBB4s80
See in Reactome
R-HSA-9612246
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612255
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612257
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612257
Reaction Name: ADAP1 gene expression is inhibited by ERBB4s80
See in Reactome
R-HSA-9612277
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612277
Reaction Name: SPARC gene transcription is stimulated by ERBB4s80
See in Reactome
R-HSA-9612278
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612440
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612444
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612445
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612445
Reaction Name: STMN1 gene expression is stimulated by ERBB4s80
See in Reactome
R-HSA-9612448
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612448
Reaction Name: MXD4 gene expression is stimulated by ERBB4s80
See in Reactome
R-HSA-9612593
(
R-HSA-1236394
)
R-HSA-9612639
(
R-HSA-1236394
)
R-HSA-9612639
Reaction Name: NRG2-activated ERBB4 binds GABA receptors through GABRA1
See in Reactome
R-HSA-9612671
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612671
Reaction Name: ERBB4 gene expression is stimulated by ERBB4s80:ESR1
See in Reactome
R-HSA-9612672
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612672
Reaction Name: ERBB4s80:ESR1 binds ERBB4 gene promoter
See in Reactome
|
MONDO:0005138 |
MET |
P08581 |
2.7.10.1
|
R-HSA-6806942
R-HSA-9022699
R-HSA-9022699
Reactome Name: MECP2 regulates neuronal receptors and channels
See in Reactome
R-HSA-1257604
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-6807004
R-HSA-6807004
Reactome Name: Negative regulation of MET activity
See in Reactome
R-HSA-8865999
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-8851805
R-HSA-8875513
R-HSA-8875513
Reactome Name: MET interacts with TNS proteins
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-8875555
R-HSA-8875791
R-HSA-8875656
R-HSA-8874081
R-HSA-9734091
R-HSA-9734091
Reactome Name: Drug-mediated inhibition of MET activation
See in Reactome
R-HSA-5673001
|
R-HSA-6806834
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-9675108
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-373755
R-HSA-422475
R-HSA-8875878
R-HSA-5684996
R-HSA-400685
R-HSA-1266738
R-HSA-73857
|
Gene expression (Transcription)
Signal Transduction
Developmental Biology
|
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-400677
(
R-HSA-416550
)
R-HSA-400677
Reaction Name: Rnd1 interacts with Plexin-B1:Sema4D
See in Reactome
R-HSA-400682
(
R-HSA-416550
)
R-HSA-400682
Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D
See in Reactome
R-HSA-416546
(
R-HSA-416550
)
R-HSA-416546
Reaction Name: Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416562
(
R-HSA-416550
)
R-HSA-419646
(
R-HSA-416550
)
R-HSA-419646
Reaction Name: SEMA4D interacts with Plexin-B1:Met
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-6800298
(
R-HSA-6806942
)
R-HSA-6806957
(
R-HSA-6806942
)
R-HSA-6806974
(
R-HSA-6806942
)
R-HSA-6807008
(
R-HSA-6807004
)
R-HSA-6807027
(
R-HSA-6807004
)
R-HSA-6807027
Reaction Name: PTPN1 and PTPN2 dephosphorylate MET
See in Reactome
R-HSA-8851804
(
R-HSA-8851805
)
R-HSA-8851804
Reaction Name: Activated MET recruits GRB2-1:SOS1
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851842
(
R-HSA-8851805
)
R-HSA-8851842
Reaction Name: MUC20 binds MET and inhibits GRB2 binding
See in Reactome
R-HSA-8851859
(
R-HSA-8851805
)
R-HSA-8851859
Reaction Name: Activated MET binds RANBP9 and SOS1
See in Reactome
R-HSA-8851866
(
R-HSA-8851805
)
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851888
(
R-HSA-8851805
)
R-HSA-8851890
(
R-HSA-8851805
)
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8851900
(
R-HSA-8851805
)
R-HSA-8851900
Reaction Name: SHC1-2 bound to MET recruits GRB2:SOS1
See in Reactome
R-HSA-8851908
(
R-HSA-8851907
)
R-HSA-8851919
(
R-HSA-8851907
)
R-HSA-8851919
Reaction Name: Activated MET binds GAB1 and GRB2
See in Reactome
R-HSA-8851933
(
R-HSA-8851907
)
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8865994
(
R-HSA-8865999
)
R-HSA-8874078
(
R-HSA-8874081
)
R-HSA-8874079
(
R-HSA-8874081
)
R-HSA-8874080
(
R-HSA-8874081
)
R-HSA-8874082
(
R-HSA-8874081
)
R-HSA-8874083
(
R-HSA-8874081
)
R-HSA-8874685
(
R-HSA-6807004
)
R-HSA-8875183
(
R-HSA-6807004
)
R-HSA-8875183
Reaction Name: CBL monoubiquitinates activated MET
See in Reactome
R-HSA-8875374
(
R-HSA-6807004
)
R-HSA-8875431
(
R-HSA-6807004
)
R-HSA-8875431
Reaction Name: LRIG1 undergoes ubiquitination
See in Reactome
R-HSA-8875443
(
R-HSA-6807004
)
R-HSA-8875451
(
R-HSA-6807004
)
R-HSA-8875482
(
R-HSA-6807004
)
R-HSA-8875482
Reaction Name: CBL recruits CIN85:endophilin to ubiquitinated MET
See in Reactome
R-HSA-8875490
(
R-HSA-6807004
)
R-HSA-8875490
Reaction Name: EPS15 and HGS bind ubiquitinated MET
See in Reactome
R-HSA-8875523
(
R-HSA-8875513
)
R-HSA-8875531
(
R-HSA-8875513
)
R-HSA-8875540
(
R-HSA-8875555
)
R-HSA-8875558
(
R-HSA-8875555
)
R-HSA-8875568
(
R-HSA-8875555
)
R-HSA-8875576
(
R-HSA-8875555
)
R-HSA-8875576
Reaction Name: CRK,CRKL recruits RAC1 GEF to activated MET
See in Reactome
R-HSA-8875591
(
R-HSA-8875555
)
R-HSA-8875659
(
R-HSA-8875656
)
R-HSA-8875659
Reaction Name: RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane
See in Reactome
R-HSA-8875661
(
R-HSA-8875656
)
R-HSA-8875661
Reaction Name: GGA3 associates with activated MET receptor
See in Reactome
R-HSA-8875816
(
R-HSA-8875791
)
R-HSA-8875816
Reaction Name: STAT3 binds activated MET receptor
See in Reactome
R-HSA-8875817
(
R-HSA-8875791
)
R-HSA-8986940
(
R-HSA-9022699
)
R-HSA-8986940
Reaction Name: MET gene transcription is stimulated by MECP2
See in Reactome
R-HSA-9734070
(
R-HSA-6807004;
R-HSA-9734091
)
R-HSA-9734070
Reaction Name: Anti-MET recombinant therapeutic antibodies bind MET
See in Reactome
R-HSA-9735946
(
R-HSA-6807004;
R-HSA-9734091
)
R-HSA-9735946
Reaction Name: Anti-MET small tyrosine kinase inhibitors bind MET
See in Reactome
|
MONDO:0005212 |
FGFR4 |
P22455 |
2.7.10.1
|
R-HSA-1257604
R-HSA-5654720
R-HSA-5654228
R-HSA-5654228
Reactome Name: Phospholipase C-mediated cascade; FGFR4
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1307965
R-HSA-1307965
Reactome Name: betaKlotho-mediated ligand binding
See in Reactome
R-HSA-190322
R-HSA-190322
Reactome Name: FGFR4 ligand binding and activation
See in Reactome
R-HSA-109704
R-HSA-5654712
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654719
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5684996
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-190236
R-HSA-74752
R-HSA-5654743
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399;
R-HSA-74751
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-1307955
(
R-HSA-1307965;
R-HSA-190322
)
R-HSA-1307963
(
R-HSA-1307965;
R-HSA-190322
)
R-HSA-1307963
Reaction Name: Autocatalytic phosphorylation of BetaKlotho-bound FGFR4
See in Reactome
R-HSA-190265
(
R-HSA-190322
)
R-HSA-190326
(
R-HSA-190322
)
R-HSA-190326
Reaction Name: Autocatalytic phosphorylation of FGFR4
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654151
(
R-HSA-5654228
)
R-HSA-5654151
Reaction Name: Activated FGFR4 phosphorylates PLCG1
See in Reactome
R-HSA-5654163
(
R-HSA-5654228
)
R-HSA-5654169
(
R-HSA-5654228
)
R-HSA-5654169
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR4
See in Reactome
R-HSA-5654418
(
R-HSA-5654712
)
R-HSA-5654418
Reaction Name: Activated FGFR4 phosphorylates FRS2
See in Reactome
R-HSA-5654422
(
R-HSA-5654712
)
R-HSA-5654423
(
R-HSA-5654719
)
R-HSA-5654423
Reaction Name: Activated FGFR4:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654425
(
R-HSA-5654719
)
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654428
(
R-HSA-5654719
)
R-HSA-5654428
Reaction Name: Activated FGFR4 phosphorylates SHC1
See in Reactome
R-HSA-5654566
(
R-HSA-5654733
)
R-HSA-5654566
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2.
See in Reactome
R-HSA-5654651
(
R-HSA-5654712
)
R-HSA-5654653
(
R-HSA-5654712
)
R-HSA-5654653
Reaction Name: Activated FGFR4 phosphorylates FRS3
See in Reactome
R-HSA-5654655
(
R-HSA-5654712
)
R-HSA-5654655
Reaction Name: Activated FGFR4 phosphorylates PPTN11
See in Reactome
R-HSA-5654658
(
R-HSA-5654712
)
R-HSA-5654658
Reaction Name: Activated FGFR4:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654659
(
R-HSA-5654720
)
R-HSA-5654659
Reaction Name: Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654664
(
R-HSA-5654712
)
R-HSA-5654664
Reaction Name: Activated FGFR4:p-FRS binds GRB2:SOS1
See in Reactome
R-HSA-5654667
(
R-HSA-5654720
)
R-HSA-5654667
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654684
(
R-HSA-5654733
)
R-HSA-5654684
Reaction Name: CBL ubiquitinates FRS2 and FGFR4
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654734
(
R-HSA-5654733
)
R-HSA-5654734
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0005223 |
FLT3 |
P36888 |
2.7.10.1
|
R-HSA-9706374
R-HSA-9706374
Reactome Name: FLT3 signaling through SRC family kinases
See in Reactome
R-HSA-1257604
R-HSA-9645135
R-HSA-9706369
R-HSA-109704
R-HSA-9607240
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5684996
R-HSA-168256
R-HSA-112399
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-74752
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Immune System
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399;
R-HSA-74751
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-6786789
(
R-HSA-9607240
)
R-HSA-8854736
(
R-HSA-9607240
)
R-HSA-9604738
(
R-HSA-9607240
)
R-HSA-9604767
(
R-HSA-9607240
)
R-HSA-9604767
Reaction Name: FLT3LG dimer:FLT3 dimer autophosphorylates
See in Reactome
R-HSA-9604969
(
R-HSA-9607240
)
R-HSA-9605259
(
R-HSA-9607240;
R-HSA-9706374
)
R-HSA-9606622
(
R-HSA-9607240
)
R-HSA-9606622
Reaction Name: GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated
See in Reactome
R-HSA-9606624
(
R-HSA-9607240
)
R-HSA-9606784
(
R-HSA-9607240
)
R-HSA-9606784
Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11
See in Reactome
R-HSA-9607224
(
R-HSA-9607240
)
R-HSA-9607224
Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1
See in Reactome
R-HSA-9607301
(
R-HSA-9607240
)
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9609274
(
R-HSA-9607240;
R-HSA-9706374
)
R-HSA-9645126
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
Reaction Name: p-STAT5 dissociates from activator:STAT5 complex
See in Reactome
R-HSA-9645137
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645137
Reaction Name: Activator phosphorylates STAT5
See in Reactome
R-HSA-9695828
(
R-HSA-9607240
)
R-HSA-9695831
(
R-HSA-9607240
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9698408
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9698408
Reaction Name: PTPRJ dephosphorylates active FLT3
See in Reactome
R-HSA-9699578
(
R-HSA-9607240
)
R-HSA-9699578
Reaction Name: Active FLT3 phosphorylates CDKN1B
See in Reactome
R-HSA-9706287
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706293
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706298
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706304
(
R-HSA-9607240
)
R-HSA-9706308
(
R-HSA-9607240
)
R-HSA-9706312
(
R-HSA-9607240;
R-HSA-9706374
)
R-HSA-9706315
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706319
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706323
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706328
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706330
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706336
(
R-HSA-9607240;
R-HSA-9706374
)
R-HSA-9706340
(
R-HSA-9607240
)
R-HSA-9706340
Reaction Name: Active FLT3:p-Y-GRB10 binds PIK3R1
See in Reactome
R-HSA-9706344
(
R-HSA-9607240
)
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706350
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706354
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706364
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706364
Reaction Name: Internalization of ubiquitinated FLT3
See in Reactome
|
MONDO:0005224 |
FLT3 |
P36888 |
2.7.10.1
|
R-HSA-9706374
R-HSA-9706374
Reactome Name: FLT3 signaling through SRC family kinases
See in Reactome
R-HSA-1257604
R-HSA-9645135
R-HSA-9706369
R-HSA-109704
R-HSA-9607240
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5684996
R-HSA-168256
R-HSA-112399
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-74752
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Immune System
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399;
R-HSA-74751
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-6786789
(
R-HSA-9607240
)
R-HSA-8854736
(
R-HSA-9607240
)
R-HSA-9604738
(
R-HSA-9607240
)
R-HSA-9604767
(
R-HSA-9607240
)
R-HSA-9604767
Reaction Name: FLT3LG dimer:FLT3 dimer autophosphorylates
See in Reactome
R-HSA-9604969
(
R-HSA-9607240
)
R-HSA-9605259
(
R-HSA-9607240;
R-HSA-9706374
)
R-HSA-9606622
(
R-HSA-9607240
)
R-HSA-9606622
Reaction Name: GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated
See in Reactome
R-HSA-9606624
(
R-HSA-9607240
)
R-HSA-9606784
(
R-HSA-9607240
)
R-HSA-9606784
Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11
See in Reactome
R-HSA-9607224
(
R-HSA-9607240
)
R-HSA-9607224
Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1
See in Reactome
R-HSA-9607301
(
R-HSA-9607240
)
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9609274
(
R-HSA-9607240;
R-HSA-9706374
)
R-HSA-9645126
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
Reaction Name: p-STAT5 dissociates from activator:STAT5 complex
See in Reactome
R-HSA-9645137
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645137
Reaction Name: Activator phosphorylates STAT5
See in Reactome
R-HSA-9695828
(
R-HSA-9607240
)
R-HSA-9695831
(
R-HSA-9607240
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9698408
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9698408
Reaction Name: PTPRJ dephosphorylates active FLT3
See in Reactome
R-HSA-9699578
(
R-HSA-9607240
)
R-HSA-9699578
Reaction Name: Active FLT3 phosphorylates CDKN1B
See in Reactome
R-HSA-9706287
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706293
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706298
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706304
(
R-HSA-9607240
)
R-HSA-9706308
(
R-HSA-9607240
)
R-HSA-9706312
(
R-HSA-9607240;
R-HSA-9706374
)
R-HSA-9706315
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706319
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706323
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706328
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706330
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706336
(
R-HSA-9607240;
R-HSA-9706374
)
R-HSA-9706340
(
R-HSA-9607240
)
R-HSA-9706340
Reaction Name: Active FLT3:p-Y-GRB10 binds PIK3R1
See in Reactome
R-HSA-9706344
(
R-HSA-9607240
)
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706350
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706354
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706364
(
R-HSA-9607240;
R-HSA-9706369
)
R-HSA-9706364
Reaction Name: Internalization of ubiquitinated FLT3
See in Reactome
|
MONDO:0005233 |
EGFR |
P00533 |
2.7.10.1
|
R-HSA-445144
R-HSA-1251932
R-HSA-1251932
Reactome Name: PLCG1 events in ERBB2 signaling
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-180292
R-HSA-1236394
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-5673001
R-HSA-9013507
R-HSA-9013507
Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus
See in Reactome
R-HSA-1257604
R-HSA-177929
R-HSA-8857538
R-HSA-8857538
Reactome Name: PTK6 promotes HIF1A stabilization
See in Reactome
R-HSA-8856828
R-HSA-8856825
R-HSA-8856825
Reactome Name: Cargo recognition for clathrin-mediated endocytosis
See in Reactome
R-HSA-1227986
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-180336
R-HSA-8847993
R-HSA-8847993
Reactome Name: ERBB2 Activates PTK6 Signaling
See in Reactome
R-HSA-212718
R-HSA-212718
Reactome Name: EGFR interacts with phospholipase C-gamma
See in Reactome
R-HSA-182971
R-HSA-179812
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-8866910
R-HSA-8866910
Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-6785631
|
R-HSA-9012852
R-HSA-157118
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-8848021
R-HSA-5684996
R-HSA-1266738
R-HSA-73857
R-HSA-8864260
R-HSA-8864260
Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5653656
R-HSA-373760
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-372790
R-HSA-416476
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-162582
|
Developmental Biology
Gene expression (Transcription)
Vesicle-mediated transport
Signal Transduction
|
R-HSA-1250195
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250195
Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers
See in Reactome
R-HSA-1250463
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250486
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250486
Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250488
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1250488
Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer
See in Reactome
R-HSA-1250498
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1251922
(
R-HSA-1227986;
R-HSA-1251932
)
R-HSA-1251922
Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2
See in Reactome
R-HSA-1251944
(
R-HSA-1227986;
R-HSA-1251932
)
R-HSA-1306957
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306963
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306963
Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-177922
(
R-HSA-177929
)
R-HSA-177923
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-177924
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177924
Reaction Name: Dephosphorylation of Gab1 by SHP2
See in Reactome
R-HSA-177925
(
R-HSA-177929;
R-HSA-180336
)
R-HSA-177925
Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex
See in Reactome
R-HSA-177926
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177926
Reaction Name: Dephosphorylation of PAG by SHP2
See in Reactome
R-HSA-177927
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177930
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177930
Reaction Name: GAB1 phosphorylation by EGFR kinase
See in Reactome
R-HSA-177933
(
R-HSA-177929;
R-HSA-180336
)
R-HSA-177933
Reaction Name: SHC1 phosphorylation by phosphorylated EGFR
See in Reactome
R-HSA-177934
(
R-HSA-177929
)
R-HSA-177935
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177935
Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR
See in Reactome
R-HSA-177936
(
R-HSA-177929;
R-HSA-180336
)
R-HSA-177936
Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR
See in Reactome
R-HSA-177937
(
R-HSA-177929
)
R-HSA-177937
Reaction Name: Phosphorylation of EGFR by SRC kinase
See in Reactome
R-HSA-177938
(
R-HSA-177929;
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177939
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-177941
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177941
Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR
See in Reactome
R-HSA-177942
(
R-HSA-177929
)
R-HSA-177943
(
R-HSA-177929;
R-HSA-179812
)
R-HSA-177943
Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex
See in Reactome
R-HSA-177944
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177944
Reaction Name: Activation of SHP2 through the binding to phospho-Gab1
See in Reactome
R-HSA-177945
(
R-HSA-177929;
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-182969
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-182969
Reaction Name: Phosphorylation of CBL (EGFR:CBL)
See in Reactome
R-HSA-182986
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-182986
Reaction Name: CBL-mediated ubiquitination of CIN85
See in Reactome
R-HSA-182990
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-182990
Reaction Name: Sprouty sequesters CBL away from active EGFR
See in Reactome
R-HSA-182993
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-182993
Reaction Name: Ubiquitination of stimulated EGFR (CBL)
See in Reactome
R-HSA-182994
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-182994
Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles
See in Reactome
R-HSA-183002
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183002
Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85
See in Reactome
R-HSA-183036
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183036
Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2)
See in Reactome
R-HSA-183051
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183055
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183058
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183058
Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL)
See in Reactome
R-HSA-183067
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183067
Reaction Name: Localization of CBL:GRB2 to the membrane
See in Reactome
R-HSA-183072
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183072
Reaction Name: EGFR non-clathrin mediated endocytosis
See in Reactome
R-HSA-183084
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183084
Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix
See in Reactome
R-HSA-183089
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183089
Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty
See in Reactome
R-HSA-1963563
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1963563
Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2
See in Reactome
R-HSA-1963578
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1963578
Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1963581
(
R-HSA-1227986
)
R-HSA-1963581
Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
See in Reactome
R-HSA-1963582
(
R-HSA-1227986
)
R-HSA-1963582
Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4
See in Reactome
R-HSA-1977959
(
R-HSA-1236394
)
R-HSA-1977959
Reaction Name: ERBB4 forms heterodimers with EGFR
See in Reactome
R-HSA-212706
(
R-HSA-177929;
R-HSA-212718
)
R-HSA-212706
Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor
See in Reactome
R-HSA-212710
(
R-HSA-177929;
R-HSA-212718
)
R-HSA-212710
Reaction Name: EGFR activates PLC-gamma1 by phosphorylation
See in Reactome
R-HSA-212713
(
R-HSA-177929;
R-HSA-212718
)
R-HSA-212713
Reaction Name: Active PLC-gamma1 dissociates from EGFR
See in Reactome
R-HSA-2179387
(
R-HSA-2179392;
R-HSA-416476;
R-HSA-881907
)
R-HSA-2179387
Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor
See in Reactome
R-HSA-2179407
(
R-HSA-2179392;
R-HSA-416476;
R-HSA-881907
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2179415
(
R-HSA-2179392;
R-HSA-416476;
R-HSA-881907
)
R-HSA-2179415
Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-445069
(
R-HSA-445144
)
R-HSA-445069
Reaction Name: L1-EGFR trans-heterodimerization
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-6785636
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-6785636
Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1
See in Reactome
R-HSA-6785648
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-8847995
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8847995
Reaction Name: Activated ERBB2 binds PTK6 (BRK)
See in Reactome
R-HSA-8848005
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8848005
Reaction Name: ERBB2 promotes PTK6 autophosphorylation
See in Reactome
R-HSA-8857549
(
R-HSA-8857538
)
R-HSA-8857549
Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB
See in Reactome
R-HSA-8857555
(
R-HSA-8857538
)
R-HSA-8857565
(
R-HSA-8857538
)
R-HSA-8857565
Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139
See in Reactome
R-HSA-8857577
(
R-HSA-8857538
)
R-HSA-8857577
Reaction Name: LINC01139 facilitates PTK6 autophosphorylation
See in Reactome
R-HSA-8857583
(
R-HSA-8857538
)
R-HSA-8857583
Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6
See in Reactome
R-HSA-8857925
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-8857925
Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307
See in Reactome
R-HSA-8863804
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8863804
Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
See in Reactome
R-HSA-8864029
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-8864029
Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172)
See in Reactome
R-HSA-8864105
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8864105
Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers
See in Reactome
R-HSA-8864125
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8864125
Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248
See in Reactome
R-HSA-8866279
(
R-HSA-8856825;
R-HSA-8856828
)
R-HSA-8866279
Reaction Name: Epsin family proteins bind ubiquitinated cargo
See in Reactome
R-HSA-8867041
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-8867044
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-8867044
Reaction Name: EGFR binds EPS15, EPN1, EPS15L1
See in Reactome
R-HSA-8867047
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-8867754
(
R-HSA-8856828
)
R-HSA-8867754
Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit
See in Reactome
R-HSA-8867756
(
R-HSA-8856828
)
R-HSA-8867756
Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
See in Reactome
R-HSA-8868071
(
R-HSA-8856828
)
R-HSA-8868072
(
R-HSA-8856828
)
R-HSA-8868072
Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
See in Reactome
R-HSA-8868230
(
R-HSA-8856828
)
R-HSA-8868230
Reaction Name: SNX9 recruits components of the actin polymerizing machinery
See in Reactome
R-HSA-8868236
(
R-HSA-8856828
)
R-HSA-8868236
Reaction Name: BAR domain proteins recruit dynamin
See in Reactome
R-HSA-8868648
(
R-HSA-8856828
)
R-HSA-8868648
Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P
See in Reactome
R-HSA-8868651
(
R-HSA-8856828
)
R-HSA-8868651
Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit
See in Reactome
R-HSA-8868658
(
R-HSA-8856828
)
R-HSA-8868658
Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
See in Reactome
R-HSA-8868659
(
R-HSA-8856828
)
R-HSA-8868659
Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle
See in Reactome
R-HSA-8868660
(
R-HSA-8856828
)
R-HSA-8868660
Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
See in Reactome
R-HSA-8868661
(
R-HSA-8856828
)
R-HSA-8868661
Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission
See in Reactome
R-HSA-8869438
(
R-HSA-8856828
)
R-HSA-8869438
Reaction Name: Dissociation of clathrin-associated proteins
See in Reactome
R-HSA-8871193
(
R-HSA-8856828
)
R-HSA-8871193
Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2
See in Reactome
R-HSA-8871194
(
R-HSA-8856828
)
R-HSA-8874797
(
R-HSA-8866910
)
R-HSA-8874797
Reaction Name: EGFR gene expression is stimulated by TFAP2C
See in Reactome
R-HSA-8951490
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-8951490
Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85
See in Reactome
R-HSA-9018572
(
R-HSA-9013507
)
R-HSA-9018573
(
R-HSA-9013507
)
R-HSA-9625465
(
R-HSA-8939211;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9625465
Reaction Name: E2-mediated FOS gene expression
See in Reactome
R-HSA-9625482
(
R-HSA-8939211;
R-HSA-9009391
)
R-HSA-9625487
(
R-HSA-8939211;
R-HSA-9009391
)
R-HSA-9625487
Reaction Name: PTK2 autophosphorylates downstream of EGFR
See in Reactome
R-HSA-9634702
(
R-HSA-8857538
)
R-HSA-9634702
Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2
See in Reactome
R-HSA-9674531
(
R-HSA-177929
)
|
MONDO:0005233 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0005335 |
EGFR |
P00533 |
2.7.10.1
|
R-HSA-445144
R-HSA-1251932
R-HSA-1251932
Reactome Name: PLCG1 events in ERBB2 signaling
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-180292
R-HSA-1236394
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-5673001
R-HSA-9013507
R-HSA-9013507
Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus
See in Reactome
R-HSA-1257604
R-HSA-177929
R-HSA-8857538
R-HSA-8857538
Reactome Name: PTK6 promotes HIF1A stabilization
See in Reactome
R-HSA-8856828
R-HSA-8856825
R-HSA-8856825
Reactome Name: Cargo recognition for clathrin-mediated endocytosis
See in Reactome
R-HSA-1227986
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-180336
R-HSA-8847993
R-HSA-8847993
Reactome Name: ERBB2 Activates PTK6 Signaling
See in Reactome
R-HSA-212718
R-HSA-212718
Reactome Name: EGFR interacts with phospholipase C-gamma
See in Reactome
R-HSA-182971
R-HSA-179812
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-8866910
R-HSA-8866910
Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-6785631
|
R-HSA-9012852
R-HSA-157118
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-8848021
R-HSA-5684996
R-HSA-1266738
R-HSA-73857
R-HSA-8864260
R-HSA-8864260
Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5653656
R-HSA-373760
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-372790
R-HSA-416476
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-162582
|
Developmental Biology
Gene expression (Transcription)
Vesicle-mediated transport
Signal Transduction
|
R-HSA-1250195
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250195
Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers
See in Reactome
R-HSA-1250463
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250486
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250486
Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250488
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1250488
Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer
See in Reactome
R-HSA-1250498
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1251922
(
R-HSA-1227986;
R-HSA-1251932
)
R-HSA-1251922
Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2
See in Reactome
R-HSA-1251944
(
R-HSA-1227986;
R-HSA-1251932
)
R-HSA-1306957
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306963
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306963
Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-177922
(
R-HSA-177929
)
R-HSA-177923
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-177924
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177924
Reaction Name: Dephosphorylation of Gab1 by SHP2
See in Reactome
R-HSA-177925
(
R-HSA-177929;
R-HSA-180336
)
R-HSA-177925
Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex
See in Reactome
R-HSA-177926
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177926
Reaction Name: Dephosphorylation of PAG by SHP2
See in Reactome
R-HSA-177927
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177930
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177930
Reaction Name: GAB1 phosphorylation by EGFR kinase
See in Reactome
R-HSA-177933
(
R-HSA-177929;
R-HSA-180336
)
R-HSA-177933
Reaction Name: SHC1 phosphorylation by phosphorylated EGFR
See in Reactome
R-HSA-177934
(
R-HSA-177929
)
R-HSA-177935
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177935
Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR
See in Reactome
R-HSA-177936
(
R-HSA-177929;
R-HSA-180336
)
R-HSA-177936
Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR
See in Reactome
R-HSA-177937
(
R-HSA-177929
)
R-HSA-177937
Reaction Name: Phosphorylation of EGFR by SRC kinase
See in Reactome
R-HSA-177938
(
R-HSA-177929;
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177939
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-177941
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177941
Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR
See in Reactome
R-HSA-177942
(
R-HSA-177929
)
R-HSA-177943
(
R-HSA-177929;
R-HSA-179812
)
R-HSA-177943
Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex
See in Reactome
R-HSA-177944
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177944
Reaction Name: Activation of SHP2 through the binding to phospho-Gab1
See in Reactome
R-HSA-177945
(
R-HSA-177929;
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-182969
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-182969
Reaction Name: Phosphorylation of CBL (EGFR:CBL)
See in Reactome
R-HSA-182986
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-182986
Reaction Name: CBL-mediated ubiquitination of CIN85
See in Reactome
R-HSA-182990
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-182990
Reaction Name: Sprouty sequesters CBL away from active EGFR
See in Reactome
R-HSA-182993
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-182993
Reaction Name: Ubiquitination of stimulated EGFR (CBL)
See in Reactome
R-HSA-182994
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-182994
Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles
See in Reactome
R-HSA-183002
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183002
Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85
See in Reactome
R-HSA-183036
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183036
Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2)
See in Reactome
R-HSA-183051
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183055
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183058
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183058
Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL)
See in Reactome
R-HSA-183067
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183067
Reaction Name: Localization of CBL:GRB2 to the membrane
See in Reactome
R-HSA-183072
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183072
Reaction Name: EGFR non-clathrin mediated endocytosis
See in Reactome
R-HSA-183084
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183084
Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix
See in Reactome
R-HSA-183089
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183089
Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty
See in Reactome
R-HSA-1963563
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1963563
Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2
See in Reactome
R-HSA-1963578
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1963578
Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1963581
(
R-HSA-1227986
)
R-HSA-1963581
Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
See in Reactome
R-HSA-1963582
(
R-HSA-1227986
)
R-HSA-1963582
Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4
See in Reactome
R-HSA-1977959
(
R-HSA-1236394
)
R-HSA-1977959
Reaction Name: ERBB4 forms heterodimers with EGFR
See in Reactome
R-HSA-212706
(
R-HSA-177929;
R-HSA-212718
)
R-HSA-212706
Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor
See in Reactome
R-HSA-212710
(
R-HSA-177929;
R-HSA-212718
)
R-HSA-212710
Reaction Name: EGFR activates PLC-gamma1 by phosphorylation
See in Reactome
R-HSA-212713
(
R-HSA-177929;
R-HSA-212718
)
R-HSA-212713
Reaction Name: Active PLC-gamma1 dissociates from EGFR
See in Reactome
R-HSA-2179387
(
R-HSA-2179392;
R-HSA-416476;
R-HSA-881907
)
R-HSA-2179387
Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor
See in Reactome
R-HSA-2179407
(
R-HSA-2179392;
R-HSA-416476;
R-HSA-881907
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2179415
(
R-HSA-2179392;
R-HSA-416476;
R-HSA-881907
)
R-HSA-2179415
Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-445069
(
R-HSA-445144
)
R-HSA-445069
Reaction Name: L1-EGFR trans-heterodimerization
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-6785636
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-6785636
Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1
See in Reactome
R-HSA-6785648
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-8847995
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8847995
Reaction Name: Activated ERBB2 binds PTK6 (BRK)
See in Reactome
R-HSA-8848005
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8848005
Reaction Name: ERBB2 promotes PTK6 autophosphorylation
See in Reactome
R-HSA-8857549
(
R-HSA-8857538
)
R-HSA-8857549
Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB
See in Reactome
R-HSA-8857555
(
R-HSA-8857538
)
R-HSA-8857565
(
R-HSA-8857538
)
R-HSA-8857565
Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139
See in Reactome
R-HSA-8857577
(
R-HSA-8857538
)
R-HSA-8857577
Reaction Name: LINC01139 facilitates PTK6 autophosphorylation
See in Reactome
R-HSA-8857583
(
R-HSA-8857538
)
R-HSA-8857583
Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6
See in Reactome
R-HSA-8857925
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-8857925
Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307
See in Reactome
R-HSA-8863804
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8863804
Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
See in Reactome
R-HSA-8864029
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-8864029
Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172)
See in Reactome
R-HSA-8864105
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8864105
Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers
See in Reactome
R-HSA-8864125
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8864125
Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248
See in Reactome
R-HSA-8866279
(
R-HSA-8856825;
R-HSA-8856828
)
R-HSA-8866279
Reaction Name: Epsin family proteins bind ubiquitinated cargo
See in Reactome
R-HSA-8867041
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-8867044
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-8867044
Reaction Name: EGFR binds EPS15, EPN1, EPS15L1
See in Reactome
R-HSA-8867047
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-8867754
(
R-HSA-8856828
)
R-HSA-8867754
Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit
See in Reactome
R-HSA-8867756
(
R-HSA-8856828
)
R-HSA-8867756
Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
See in Reactome
R-HSA-8868071
(
R-HSA-8856828
)
R-HSA-8868072
(
R-HSA-8856828
)
R-HSA-8868072
Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
See in Reactome
R-HSA-8868230
(
R-HSA-8856828
)
R-HSA-8868230
Reaction Name: SNX9 recruits components of the actin polymerizing machinery
See in Reactome
R-HSA-8868236
(
R-HSA-8856828
)
R-HSA-8868236
Reaction Name: BAR domain proteins recruit dynamin
See in Reactome
R-HSA-8868648
(
R-HSA-8856828
)
R-HSA-8868648
Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P
See in Reactome
R-HSA-8868651
(
R-HSA-8856828
)
R-HSA-8868651
Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit
See in Reactome
R-HSA-8868658
(
R-HSA-8856828
)
R-HSA-8868658
Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
See in Reactome
R-HSA-8868659
(
R-HSA-8856828
)
R-HSA-8868659
Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle
See in Reactome
R-HSA-8868660
(
R-HSA-8856828
)
R-HSA-8868660
Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
See in Reactome
R-HSA-8868661
(
R-HSA-8856828
)
R-HSA-8868661
Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission
See in Reactome
R-HSA-8869438
(
R-HSA-8856828
)
R-HSA-8869438
Reaction Name: Dissociation of clathrin-associated proteins
See in Reactome
R-HSA-8871193
(
R-HSA-8856828
)
R-HSA-8871193
Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2
See in Reactome
R-HSA-8871194
(
R-HSA-8856828
)
R-HSA-8874797
(
R-HSA-8866910
)
R-HSA-8874797
Reaction Name: EGFR gene expression is stimulated by TFAP2C
See in Reactome
R-HSA-8951490
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-8951490
Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85
See in Reactome
R-HSA-9018572
(
R-HSA-9013507
)
R-HSA-9018573
(
R-HSA-9013507
)
R-HSA-9625465
(
R-HSA-8939211;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9625465
Reaction Name: E2-mediated FOS gene expression
See in Reactome
R-HSA-9625482
(
R-HSA-8939211;
R-HSA-9009391
)
R-HSA-9625487
(
R-HSA-8939211;
R-HSA-9009391
)
R-HSA-9625487
Reaction Name: PTK2 autophosphorylates downstream of EGFR
See in Reactome
R-HSA-9634702
(
R-HSA-8857538
)
R-HSA-9634702
Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2
See in Reactome
R-HSA-9674531
(
R-HSA-177929
)
|
MONDO:0005335 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0005375 |
FGFR2 |
P21802 |
2.7.10.1
|
R-HSA-5654221
R-HSA-5654221
Reactome Name: Phospholipase C-mediated cascade; FGFR2
See in Reactome
R-HSA-190377
R-HSA-190377
Reactome Name: FGFR2b ligand binding and activation
See in Reactome
R-HSA-190375
R-HSA-190375
Reactome Name: FGFR2c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-109704
R-HSA-5654700
R-HSA-5654699
R-HSA-5654695
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5654738
R-HSA-74752
R-HSA-190241
R-HSA-190241
Reactome Name: FGFR2 ligand binding and activation
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-190236
R-HSA-5684996
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399;
R-HSA-74751
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190258
(
R-HSA-190375
)
R-HSA-190260
(
R-HSA-190377
)
R-HSA-190408
(
R-HSA-190377
)
R-HSA-190408
Reaction Name: Autocatalytic phosphorylation of FGFR2b
See in Reactome
R-HSA-190413
(
R-HSA-190375
)
R-HSA-190413
Reaction Name: Autocatalytic phosphorylation of FGFR2c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654147
(
R-HSA-5654221
)
R-HSA-5654147
Reaction Name: Activated FGFR2 phosphorylates PLCG1
See in Reactome
R-HSA-5654157
(
R-HSA-5654221
)
R-HSA-5654157
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR2
See in Reactome
R-HSA-5654159
(
R-HSA-5654221
)
R-HSA-5654397
(
R-HSA-5654700
)
R-HSA-5654397
Reaction Name: Activated FGFR2 phosphorylates FRS2
See in Reactome
R-HSA-5654399
(
R-HSA-5654700
)
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654404
(
R-HSA-5654699
)
R-HSA-5654406
(
R-HSA-5654699
)
R-HSA-5654406
Reaction Name: Activated FGFR2:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654407
(
R-HSA-5654699
)
R-HSA-5654407
Reaction Name: Activated FGFR2 phosphorylates SHC1
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654603
(
R-HSA-5654700
)
R-HSA-5654605
(
R-HSA-5654700
)
R-HSA-5654605
Reaction Name: Activated FGFR2 phosphorylates FRS3
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654612
(
R-HSA-5654695
)
R-HSA-5654612
Reaction Name: Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654615
(
R-HSA-5654700
)
R-HSA-5654615
Reaction Name: Activated FGFR2:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0005486 |
MONDO:0005486
Disease Name: tooth agenesis
OMIM id: OMIM:617073
Orphanet id: Orphanet:99798
All associated enzymes in DAR:
FGFR1
. The disease is also associated to other non-enzyme proteins (not in DAR).
FGFR1 |
P11362 |
2.7.10.1
|
R-HSA-445144
R-HSA-190374
R-HSA-190374
Reactome Name: FGFR1c and Klotho ligand binding and activation
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-1257604
R-HSA-190370
R-HSA-190370
Reactome Name: FGFR1b ligand binding and activation
See in Reactome
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-5654689
R-HSA-5654688
R-HSA-5673001
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-109704
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654219
R-HSA-5654219
Reactome Name: Phospholipase C-mediated cascade: FGFR1
See in Reactome
R-HSA-5654693
R-HSA-190373
R-HSA-190373
Reactome Name: FGFR1c ligand binding and activation
See in Reactome
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-373760
R-HSA-190236
R-HSA-190242
R-HSA-190242
Reactome Name: FGFR1 ligand binding and activation
See in Reactome
R-HSA-74752
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-9675108
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-162582
R-HSA-5654736
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5684996
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
Developmental Biology
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-74751
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190245
(
R-HSA-190370
)
R-HSA-190256
(
R-HSA-190373
)
R-HSA-190268
(
R-HSA-190374
)
R-HSA-190268
Reaction Name: FGFR1c binds to Klotho-bound FGF23
See in Reactome
R-HSA-190427
(
R-HSA-190370
)
R-HSA-190427
Reaction Name: Autocatalytic phosphorylation of FGFR1b
See in Reactome
R-HSA-190429
(
R-HSA-190373
)
R-HSA-190429
Reaction Name: Autocatalytic phosphorylation of FGFR1c
See in Reactome
R-HSA-191062
(
R-HSA-190374
)
R-HSA-191062
Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-419033
(
R-HSA-375165
)
R-HSA-437230
(
R-HSA-445144
)
R-HSA-5654149
(
R-HSA-5654219;
R-HSA-5654687
)
R-HSA-5654149
Reaction Name: Activated FGFR1 phosphorylates PLCG1
See in Reactome
R-HSA-5654165
(
R-HSA-5654219;
R-HSA-5654687
)
R-HSA-5654165
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1
See in Reactome
R-HSA-5654167
(
R-HSA-5654219;
R-HSA-5654687
)
R-HSA-5654392
(
R-HSA-5654687;
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654514
(
R-HSA-5654726
)
R-HSA-5654560
(
R-HSA-5654726
)
R-HSA-5654560
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2.
See in Reactome
R-HSA-5654569
(
R-HSA-5654687;
R-HSA-5654693
)
R-HSA-5654571
(
R-HSA-5654687;
R-HSA-5654693
)
R-HSA-5654573
(
R-HSA-5654687;
R-HSA-5654688
)
R-HSA-5654575
(
R-HSA-5654687;
R-HSA-5654693
)
R-HSA-5654575
Reaction Name: Activated FGFR1 phosphorylates FRS2
See in Reactome
R-HSA-5654578
(
R-HSA-5654687;
R-HSA-5654693
)
R-HSA-5654578
Reaction Name: Activated FGFR1 phosphorylates FRS3
See in Reactome
R-HSA-5654582
(
R-HSA-5654687;
R-HSA-5654688
)
R-HSA-5654582
Reaction Name: Activated FGFR1 phosphorylates SHC1
See in Reactome
R-HSA-5654584
(
R-HSA-5654687;
R-HSA-5654693
)
R-HSA-5654584
Reaction Name: Activated FGFR1:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654586
(
R-HSA-5654687;
R-HSA-5654693
)
R-HSA-5654586
Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1
See in Reactome
R-HSA-5654587
(
R-HSA-5654687;
R-HSA-5654693
)
R-HSA-5654587
Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11
See in Reactome
R-HSA-5654591
(
R-HSA-5654687;
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654592
(
R-HSA-5654687;
R-HSA-5654689
)
R-HSA-5654592
Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654594
(
R-HSA-5654687;
R-HSA-5654689
)
R-HSA-5654594
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654596
(
R-HSA-5654687;
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654597
(
R-HSA-5654687;
R-HSA-5654688
)
R-HSA-5654597
Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654600
(
R-HSA-5654687;
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654672
(
R-HSA-5654726
)
R-HSA-5654672
Reaction Name: CBL ubiquitinates FRS2 and FGFR1
See in Reactome
R-HSA-5654673
(
R-HSA-5654726
)
R-HSA-5654673
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1
See in Reactome
R-HSA-5654690
(
R-HSA-5654687;
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654687;
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5656064
(
R-HSA-5654687
)
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654687;
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
NRAS |
P01111 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-6798695
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-5654741
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-109807
(
R-HSA-74751
)
R-HSA-109807
Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-109817
(
R-HSA-112412;
R-HSA-74751
)
R-HSA-109817
Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-1168636
(
R-HSA-1169092
)
R-HSA-1168636
Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
See in Reactome
R-HSA-1250383
(
R-HSA-1236394;
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1236394;
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250498
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1306972
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1433471
(
R-HSA-1433557
)
R-HSA-1433471
Reaction Name: Activation of RAS by p-KIT bound SOS1
See in Reactome
R-HSA-170986
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
(
R-HSA-167044;
R-HSA-171007
)
R-HSA-171026
Reaction Name: Guanine nucleotide exchange on RAL
See in Reactome
R-HSA-177938
(
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177945
(
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-186834
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-186834
Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
See in Reactome
R-HSA-210977
(
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-2179407
(
R-HSA-2179392
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2424477
(
R-HSA-2424491;
R-HSA-2871796
)
R-HSA-2424477
Reaction Name: SOS mediated nucleotide exchange of RAS (SHC)
See in Reactome
R-HSA-392054
(
R-HSA-375165
)
R-HSA-392054
Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
See in Reactome
R-HSA-442732
(
R-HSA-442982
)
R-HSA-442732
Reaction Name: NMDA-activated RASGRF1 activates RAS
See in Reactome
R-HSA-5218845
(
R-HSA-5218921
)
R-HSA-5218845
Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
See in Reactome
R-HSA-5621573
(
R-HSA-5621575
)
R-HSA-5624486
(
R-HSA-5621575
)
R-HSA-5624486
Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341
See in Reactome
R-HSA-5624492
(
R-HSA-5621575
)
R-HSA-5624492
Reaction Name: PAK phosphorylates p21 RAF1 on S338
See in Reactome
R-HSA-5624494
(
R-HSA-5621575
)
R-HSA-5654392
(
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654426
(
R-HSA-5654719
)
R-HSA-5654426
Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654600
(
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654663
(
R-HSA-5654712
)
R-HSA-5654663
Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5658231
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658231
Reaction Name: RAS GAPs stimulate RAS GTPase activity
See in Reactome
R-HSA-5658435
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5672950
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672950
Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-5672966
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672966
Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
See in Reactome
R-HSA-5672969
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674018
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5674022
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675417
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675431
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675433
Reaction Name: PP5 dephosphorylates RAF1 S338
See in Reactome
R-HSA-5686071
(
R-HSA-167044
)
R-HSA-5686071
Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS
See in Reactome
R-HSA-5686318
(
R-HSA-2428933
)
R-HSA-5686318
Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-8851827
(
R-HSA-8851805
)
R-HSA-8851827
Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
See in Reactome
R-HSA-8851877
(
R-HSA-8851805
)
R-HSA-8851877
Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
See in Reactome
R-HSA-8851899
(
R-HSA-8851805
)
R-HSA-8851899
Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
See in Reactome
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8981353
(
R-HSA-8849471
)
R-HSA-8981353
Reaction Name: RASA1 stimulates RAS GTPase activity
See in Reactome
R-HSA-8981355
(
R-HSA-8849471
)
R-HSA-9026891
(
R-HSA-9026519
)
R-HSA-9026891
Reaction Name: NTRK2 activates RAS signaling through SHC1
See in Reactome
R-HSA-9029158
(
R-HSA-9006335;
R-HSA-9027284
)
R-HSA-9029158
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-9036970
(
R-HSA-9034864
)
R-HSA-9036970
Reaction Name: NTRK3 activates RAS through SHC1
See in Reactome
R-HSA-9607304
(
R-HSA-9607240
)
R-HSA-9607304
Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3
See in Reactome
R-HSA-9632906
(
R-HSA-9634635
)
R-HSA-9632906
Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation
See in Reactome
R-HSA-9632910
(
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9632918
(
R-HSA-9634635
)
R-HSA-9632918
Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647980
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647980
Reaction Name: mature RAS proteins translocate to plasma membrane
See in Reactome
R-HSA-9647982
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647982
Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated
See in Reactome
R-HSA-9647994
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647994
Reaction Name: RAS proteins are depalmitoylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9649733
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9649735
(
R-HSA-5673001
)
R-HSA-9649735
Reaction Name: Intrinsic nucleotide exchange on RAS
See in Reactome
R-HSA-9649736
(
R-HSA-5673001
)
R-HSA-9649736
Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP
See in Reactome
R-HSA-9653108
(
R-HSA-5673000;
R-HSA-5673001
)
R-HSA-9653108
Reaction Name: Raf dimer inhibitors bind RAF heterodimers
See in Reactome
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
RET |
P07949 |
2.7.10.1
|
R-HSA-8853659
R-HSA-5673001
|
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-9675108
R-HSA-162582
R-HSA-422475
R-HSA-5684996
R-HSA-1266738
|
Signal Transduction
Developmental Biology
|
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8853734
(
R-HSA-8853659
)
R-HSA-8853734
Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1
See in Reactome
R-HSA-8853737
(
R-HSA-8853659
)
R-HSA-8853737
Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind SHC1
See in Reactome
R-HSA-8853745
(
R-HSA-8853659
)
R-HSA-8853753
(
R-HSA-8853659
)
R-HSA-8853753
Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10
See in Reactome
R-HSA-8853755
(
R-HSA-8853659
)
R-HSA-8853755
Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1
See in Reactome
R-HSA-8853762
(
R-HSA-8853659
)
R-HSA-8853774
(
R-HSA-8853659
)
R-HSA-8853774
Reaction Name: GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated
See in Reactome
R-HSA-8853789
(
R-HSA-8853659
)
R-HSA-8853789
Reaction Name: GDNF,NRTN bind RET:GFRA1,GFRA2
See in Reactome
R-HSA-8853792
(
R-HSA-8853659
)
R-HSA-8853793
(
R-HSA-8853659
)
R-HSA-8853800
(
R-HSA-8853659
)
R-HSA-8853801
(
R-HSA-8853659
)
R-HSA-8854897
(
R-HSA-8853659
)
R-HSA-8854897
Reaction Name: p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2
See in Reactome
R-HSA-8854899
(
R-HSA-8853659
)
R-HSA-8854899
Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1
See in Reactome
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-8854908
(
R-HSA-8853659
)
R-HSA-8854908
Reaction Name: PKA phosphorylates RET:GDNF:GFRA dimer
See in Reactome
R-HSA-8854981
(
R-HSA-8853659
)
R-HSA-8854981
Reaction Name: SHC1 in the RET complex is phosphorylated
See in Reactome
R-HSA-8855508
(
R-HSA-8853659
)
R-HSA-8855508
Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
See in Reactome
R-HSA-8855564
(
R-HSA-8853659
)
R-HSA-8855564
Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind FRS2
See in Reactome
R-HSA-8855617
(
R-HSA-8853659
)
R-HSA-8855617
Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6
See in Reactome
R-HSA-8855747
(
R-HSA-8853659
)
R-HSA-8855747
Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP
See in Reactome
R-HSA-8855915
(
R-HSA-8853659
)
R-HSA-8855915
Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors
See in Reactome
R-HSA-8871226
(
R-HSA-8853659
)
R-HSA-8871227
(
R-HSA-8853659
)
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
FGFR3 |
P22607 |
2.7.10.1
|
R-HSA-190372
R-HSA-190372
Reactome Name: FGFR3c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-5654227
R-HSA-5654227
Reactome Name: Phospholipase C-mediated cascade; FGFR3
See in Reactome
R-HSA-190371
R-HSA-190371
Reactome Name: FGFR3b ligand binding and activation
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654710
R-HSA-109704
R-HSA-5654706
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654704
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5684996
R-HSA-190239
R-HSA-190239
Reactome Name: FGFR3 ligand binding and activation
See in Reactome
R-HSA-190236
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-5654741
R-HSA-74752
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190261
(
R-HSA-190372
)
R-HSA-190263
(
R-HSA-190371
)
R-HSA-190385
(
R-HSA-190371
)
R-HSA-190385
Reaction Name: Autocatalytic phosphorylation of FGFR3b
See in Reactome
R-HSA-190388
(
R-HSA-190372
)
R-HSA-190388
Reaction Name: Autocatalytic phosphorylation of FGFR3c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654148
(
R-HSA-5654227
)
R-HSA-5654148
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR3
See in Reactome
R-HSA-5654222
(
R-HSA-5654227
)
R-HSA-5654222
Reaction Name: Activated FGFR3 phosphorylates PLCG1
See in Reactome
R-HSA-5654224
(
R-HSA-5654227
)
R-HSA-5654408
(
R-HSA-5654706
)
R-HSA-5654408
Reaction Name: Activated FGFR3 phosphorylates FRS2
See in Reactome
R-HSA-5654409
(
R-HSA-5654706
)
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654416
(
R-HSA-5654706
)
R-HSA-5654416
Reaction Name: Activated FGFR3:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654565
(
R-HSA-5654732
)
R-HSA-5654565
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2.
See in Reactome
R-HSA-5654623
(
R-HSA-5654706
)
R-HSA-5654625
(
R-HSA-5654704
)
R-HSA-5654628
(
R-HSA-5654706
)
R-HSA-5654628
Reaction Name: Activated FGFR3 phosphorylates FRS3
See in Reactome
R-HSA-5654631
(
R-HSA-5654706
)
R-HSA-5654631
Reaction Name: Activated FGFR3 phosphorylates PPTN11
See in Reactome
R-HSA-5654633
(
R-HSA-5654706
)
R-HSA-5654633
Reaction Name: Activated FGFR3:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654634
(
R-HSA-5654704
)
R-HSA-5654634
Reaction Name: Activated FGFR3 phosphorylates SHC1
See in Reactome
R-HSA-5654637
(
R-HSA-5654710
)
R-HSA-5654637
Reaction Name: Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654641
(
R-HSA-5654710
)
R-HSA-5654641
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654646
(
R-HSA-5654704
)
R-HSA-5654646
Reaction Name: Activated FGFR3:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654679
(
R-HSA-5654732
)
R-HSA-5654679
Reaction Name: CBL ubiquitinates FRS2 and FGFR3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654730
(
R-HSA-5654732
)
R-HSA-5654730
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399;
R-HSA-74751
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1236394;
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1236394;
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763;
R-HSA-186797
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654687;
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654687;
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654687;
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654687;
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399;
R-HSA-74751
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9006335;
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0005580 |
EGFR |
P00533 |
2.7.10.1
|
R-HSA-445144
R-HSA-1251932
R-HSA-1251932
Reactome Name: PLCG1 events in ERBB2 signaling
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-180292
R-HSA-1236394
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-5673001
R-HSA-9013507
R-HSA-9013507
Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus
See in Reactome
R-HSA-1257604
R-HSA-177929
R-HSA-8857538
R-HSA-8857538
Reactome Name: PTK6 promotes HIF1A stabilization
See in Reactome
R-HSA-8856828
R-HSA-8856825
R-HSA-8856825
Reactome Name: Cargo recognition for clathrin-mediated endocytosis
See in Reactome
R-HSA-1227986
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-180336
R-HSA-8847993
R-HSA-8847993
Reactome Name: ERBB2 Activates PTK6 Signaling
See in Reactome
R-HSA-212718
R-HSA-212718
Reactome Name: EGFR interacts with phospholipase C-gamma
See in Reactome
R-HSA-182971
R-HSA-179812
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-8866910
R-HSA-8866910
Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-6785631
|
R-HSA-9012852
R-HSA-157118
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-8848021
R-HSA-5684996
R-HSA-1266738
R-HSA-73857
R-HSA-8864260
R-HSA-8864260
Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5653656
R-HSA-373760
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-372790
R-HSA-416476
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-162582
|
Developmental Biology
Gene expression (Transcription)
Vesicle-mediated transport
Signal Transduction
|
R-HSA-1250195
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250195
Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers
See in Reactome
R-HSA-1250463
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250486
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250486
Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250488
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1250488
Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer
See in Reactome
R-HSA-1250498
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1251922
(
R-HSA-1227986;
R-HSA-1251932
)
R-HSA-1251922
Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2
See in Reactome
R-HSA-1251944
(
R-HSA-1227986;
R-HSA-1251932
)
R-HSA-1306957
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306963
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306963
Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-177922
(
R-HSA-177929
)
R-HSA-177923
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-177924
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177924
Reaction Name: Dephosphorylation of Gab1 by SHP2
See in Reactome
R-HSA-177925
(
R-HSA-177929;
R-HSA-180336
)
R-HSA-177925
Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex
See in Reactome
R-HSA-177926
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177926
Reaction Name: Dephosphorylation of PAG by SHP2
See in Reactome
R-HSA-177927
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177930
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177930
Reaction Name: GAB1 phosphorylation by EGFR kinase
See in Reactome
R-HSA-177933
(
R-HSA-177929;
R-HSA-180336
)
R-HSA-177933
Reaction Name: SHC1 phosphorylation by phosphorylated EGFR
See in Reactome
R-HSA-177934
(
R-HSA-177929
)
R-HSA-177935
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177935
Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR
See in Reactome
R-HSA-177936
(
R-HSA-177929;
R-HSA-180336
)
R-HSA-177936
Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR
See in Reactome
R-HSA-177937
(
R-HSA-177929
)
R-HSA-177937
Reaction Name: Phosphorylation of EGFR by SRC kinase
See in Reactome
R-HSA-177938
(
R-HSA-177929;
R-HSA-179812
)
R-HSA-177938
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
See in Reactome
R-HSA-177939
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-177941
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177941
Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR
See in Reactome
R-HSA-177942
(
R-HSA-177929
)
R-HSA-177943
(
R-HSA-177929;
R-HSA-179812
)
R-HSA-177943
Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex
See in Reactome
R-HSA-177944
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177944
Reaction Name: Activation of SHP2 through the binding to phospho-Gab1
See in Reactome
R-HSA-177945
(
R-HSA-177929;
R-HSA-180336
)
R-HSA-177945
Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
See in Reactome
R-HSA-182969
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-182969
Reaction Name: Phosphorylation of CBL (EGFR:CBL)
See in Reactome
R-HSA-182986
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-182986
Reaction Name: CBL-mediated ubiquitination of CIN85
See in Reactome
R-HSA-182990
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-182990
Reaction Name: Sprouty sequesters CBL away from active EGFR
See in Reactome
R-HSA-182993
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-182993
Reaction Name: Ubiquitination of stimulated EGFR (CBL)
See in Reactome
R-HSA-182994
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-182994
Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles
See in Reactome
R-HSA-183002
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183002
Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85
See in Reactome
R-HSA-183036
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183036
Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2)
See in Reactome
R-HSA-183051
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183055
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183058
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183058
Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL)
See in Reactome
R-HSA-183067
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183067
Reaction Name: Localization of CBL:GRB2 to the membrane
See in Reactome
R-HSA-183072
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183072
Reaction Name: EGFR non-clathrin mediated endocytosis
See in Reactome
R-HSA-183084
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183084
Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix
See in Reactome
R-HSA-183089
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-183089
Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty
See in Reactome
R-HSA-1963563
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1963563
Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2
See in Reactome
R-HSA-1963578
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1963578
Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1963581
(
R-HSA-1227986
)
R-HSA-1963581
Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
See in Reactome
R-HSA-1963582
(
R-HSA-1227986
)
R-HSA-1963582
Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4
See in Reactome
R-HSA-1977959
(
R-HSA-1236394
)
R-HSA-1977959
Reaction Name: ERBB4 forms heterodimers with EGFR
See in Reactome
R-HSA-212706
(
R-HSA-177929;
R-HSA-212718
)
R-HSA-212706
Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor
See in Reactome
R-HSA-212710
(
R-HSA-177929;
R-HSA-212718
)
R-HSA-212710
Reaction Name: EGFR activates PLC-gamma1 by phosphorylation
See in Reactome
R-HSA-212713
(
R-HSA-177929;
R-HSA-212718
)
R-HSA-212713
Reaction Name: Active PLC-gamma1 dissociates from EGFR
See in Reactome
R-HSA-2179387
(
R-HSA-2179392;
R-HSA-416476;
R-HSA-881907
)
R-HSA-2179387
Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor
See in Reactome
R-HSA-2179407
(
R-HSA-2179392;
R-HSA-416476;
R-HSA-881907
)
R-HSA-2179407
Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
See in Reactome
R-HSA-2179415
(
R-HSA-2179392;
R-HSA-416476;
R-HSA-881907
)
R-HSA-2179415
Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-445069
(
R-HSA-445144
)
R-HSA-445069
Reaction Name: L1-EGFR trans-heterodimerization
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-6785636
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-6785636
Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1
See in Reactome
R-HSA-6785648
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-8847995
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8847995
Reaction Name: Activated ERBB2 binds PTK6 (BRK)
See in Reactome
R-HSA-8848005
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8848005
Reaction Name: ERBB2 promotes PTK6 autophosphorylation
See in Reactome
R-HSA-8857549
(
R-HSA-8857538
)
R-HSA-8857549
Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB
See in Reactome
R-HSA-8857555
(
R-HSA-8857538
)
R-HSA-8857565
(
R-HSA-8857538
)
R-HSA-8857565
Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139
See in Reactome
R-HSA-8857577
(
R-HSA-8857538
)
R-HSA-8857577
Reaction Name: LINC01139 facilitates PTK6 autophosphorylation
See in Reactome
R-HSA-8857583
(
R-HSA-8857538
)
R-HSA-8857583
Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6
See in Reactome
R-HSA-8857925
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-8857925
Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307
See in Reactome
R-HSA-8863804
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8863804
Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
See in Reactome
R-HSA-8864029
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-8864029
Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172)
See in Reactome
R-HSA-8864105
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8864105
Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers
See in Reactome
R-HSA-8864125
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8864125
Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248
See in Reactome
R-HSA-8866279
(
R-HSA-8856825;
R-HSA-8856828
)
R-HSA-8866279
Reaction Name: Epsin family proteins bind ubiquitinated cargo
See in Reactome
R-HSA-8867041
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-8867044
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-8867044
Reaction Name: EGFR binds EPS15, EPN1, EPS15L1
See in Reactome
R-HSA-8867047
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-8867754
(
R-HSA-8856828
)
R-HSA-8867754
Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit
See in Reactome
R-HSA-8867756
(
R-HSA-8856828
)
R-HSA-8867756
Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
See in Reactome
R-HSA-8868071
(
R-HSA-8856828
)
R-HSA-8868072
(
R-HSA-8856828
)
R-HSA-8868072
Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
See in Reactome
R-HSA-8868230
(
R-HSA-8856828
)
R-HSA-8868230
Reaction Name: SNX9 recruits components of the actin polymerizing machinery
See in Reactome
R-HSA-8868236
(
R-HSA-8856828
)
R-HSA-8868236
Reaction Name: BAR domain proteins recruit dynamin
See in Reactome
R-HSA-8868648
(
R-HSA-8856828
)
R-HSA-8868648
Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P
See in Reactome
R-HSA-8868651
(
R-HSA-8856828
)
R-HSA-8868651
Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit
See in Reactome
R-HSA-8868658
(
R-HSA-8856828
)
R-HSA-8868658
Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
See in Reactome
R-HSA-8868659
(
R-HSA-8856828
)
R-HSA-8868659
Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle
See in Reactome
R-HSA-8868660
(
R-HSA-8856828
)
R-HSA-8868660
Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
See in Reactome
R-HSA-8868661
(
R-HSA-8856828
)
R-HSA-8868661
Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission
See in Reactome
R-HSA-8869438
(
R-HSA-8856828
)
R-HSA-8869438
Reaction Name: Dissociation of clathrin-associated proteins
See in Reactome
R-HSA-8871193
(
R-HSA-8856828
)
R-HSA-8871193
Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2
See in Reactome
R-HSA-8871194
(
R-HSA-8856828
)
R-HSA-8874797
(
R-HSA-8866910
)
R-HSA-8874797
Reaction Name: EGFR gene expression is stimulated by TFAP2C
See in Reactome
R-HSA-8951490
(
R-HSA-177929;
R-HSA-182971
)
R-HSA-8951490
Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85
See in Reactome
R-HSA-9018572
(
R-HSA-9013507
)
R-HSA-9018573
(
R-HSA-9013507
)
R-HSA-9625465
(
R-HSA-8939211;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9625465
Reaction Name: E2-mediated FOS gene expression
See in Reactome
R-HSA-9625482
(
R-HSA-8939211;
R-HSA-9009391
)
R-HSA-9625487
(
R-HSA-8939211;
R-HSA-9009391
)
R-HSA-9625487
Reaction Name: PTK2 autophosphorylates downstream of EGFR
See in Reactome
R-HSA-9634702
(
R-HSA-8857538
)
R-HSA-9634702
Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2
See in Reactome
R-HSA-9674531
(
R-HSA-177929
)
|
MONDO:0007037 |
FGFR3 |
P22607 |
2.7.10.1
|
R-HSA-190372
R-HSA-190372
Reactome Name: FGFR3c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-5654227
R-HSA-5654227
Reactome Name: Phospholipase C-mediated cascade; FGFR3
See in Reactome
R-HSA-190371
R-HSA-190371
Reactome Name: FGFR3b ligand binding and activation
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654710
R-HSA-109704
R-HSA-5654706
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654704
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5684996
R-HSA-190239
R-HSA-190239
Reactome Name: FGFR3 ligand binding and activation
See in Reactome
R-HSA-190236
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-5654741
R-HSA-74752
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190261
(
R-HSA-190372
)
R-HSA-190263
(
R-HSA-190371
)
R-HSA-190385
(
R-HSA-190371
)
R-HSA-190385
Reaction Name: Autocatalytic phosphorylation of FGFR3b
See in Reactome
R-HSA-190388
(
R-HSA-190372
)
R-HSA-190388
Reaction Name: Autocatalytic phosphorylation of FGFR3c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654148
(
R-HSA-5654227
)
R-HSA-5654148
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR3
See in Reactome
R-HSA-5654222
(
R-HSA-5654227
)
R-HSA-5654222
Reaction Name: Activated FGFR3 phosphorylates PLCG1
See in Reactome
R-HSA-5654224
(
R-HSA-5654227
)
R-HSA-5654408
(
R-HSA-5654706
)
R-HSA-5654408
Reaction Name: Activated FGFR3 phosphorylates FRS2
See in Reactome
R-HSA-5654409
(
R-HSA-5654706
)
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654416
(
R-HSA-5654706
)
R-HSA-5654416
Reaction Name: Activated FGFR3:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654565
(
R-HSA-5654732
)
R-HSA-5654565
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2.
See in Reactome
R-HSA-5654623
(
R-HSA-5654706
)
R-HSA-5654625
(
R-HSA-5654704
)
R-HSA-5654628
(
R-HSA-5654706
)
R-HSA-5654628
Reaction Name: Activated FGFR3 phosphorylates FRS3
See in Reactome
R-HSA-5654631
(
R-HSA-5654706
)
R-HSA-5654631
Reaction Name: Activated FGFR3 phosphorylates PPTN11
See in Reactome
R-HSA-5654633
(
R-HSA-5654706
)
R-HSA-5654633
Reaction Name: Activated FGFR3:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654634
(
R-HSA-5654704
)
R-HSA-5654634
Reaction Name: Activated FGFR3 phosphorylates SHC1
See in Reactome
R-HSA-5654637
(
R-HSA-5654710
)
R-HSA-5654637
Reaction Name: Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654641
(
R-HSA-5654710
)
R-HSA-5654641
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654646
(
R-HSA-5654704
)
R-HSA-5654646
Reaction Name: Activated FGFR3:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654679
(
R-HSA-5654732
)
R-HSA-5654679
Reaction Name: CBL ubiquitinates FRS2 and FGFR3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654730
(
R-HSA-5654732
)
R-HSA-5654730
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0007041 |
FGFR2 |
P21802 |
2.7.10.1
|
R-HSA-5654221
R-HSA-5654221
Reactome Name: Phospholipase C-mediated cascade; FGFR2
See in Reactome
R-HSA-190377
R-HSA-190377
Reactome Name: FGFR2b ligand binding and activation
See in Reactome
R-HSA-190375
R-HSA-190375
Reactome Name: FGFR2c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-109704
R-HSA-5654700
R-HSA-5654699
R-HSA-5654695
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5654738
R-HSA-74752
R-HSA-190241
R-HSA-190241
Reactome Name: FGFR2 ligand binding and activation
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-190236
R-HSA-5684996
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399;
R-HSA-74751
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190258
(
R-HSA-190375
)
R-HSA-190260
(
R-HSA-190377
)
R-HSA-190408
(
R-HSA-190377
)
R-HSA-190408
Reaction Name: Autocatalytic phosphorylation of FGFR2b
See in Reactome
R-HSA-190413
(
R-HSA-190375
)
R-HSA-190413
Reaction Name: Autocatalytic phosphorylation of FGFR2c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654147
(
R-HSA-5654221
)
R-HSA-5654147
Reaction Name: Activated FGFR2 phosphorylates PLCG1
See in Reactome
R-HSA-5654157
(
R-HSA-5654221
)
R-HSA-5654157
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR2
See in Reactome
R-HSA-5654159
(
R-HSA-5654221
)
R-HSA-5654397
(
R-HSA-5654700
)
R-HSA-5654397
Reaction Name: Activated FGFR2 phosphorylates FRS2
See in Reactome
R-HSA-5654399
(
R-HSA-5654700
)
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654404
(
R-HSA-5654699
)
R-HSA-5654406
(
R-HSA-5654699
)
R-HSA-5654406
Reaction Name: Activated FGFR2:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654407
(
R-HSA-5654699
)
R-HSA-5654407
Reaction Name: Activated FGFR2 phosphorylates SHC1
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654603
(
R-HSA-5654700
)
R-HSA-5654605
(
R-HSA-5654700
)
R-HSA-5654605
Reaction Name: Activated FGFR2 phosphorylates FRS3
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654612
(
R-HSA-5654695
)
R-HSA-5654612
Reaction Name: Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654615
(
R-HSA-5654700
)
R-HSA-5654615
Reaction Name: Activated FGFR2:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0007042 |
FGFR2 |
P21802 |
2.7.10.1
|
R-HSA-5654221
R-HSA-5654221
Reactome Name: Phospholipase C-mediated cascade; FGFR2
See in Reactome
R-HSA-190377
R-HSA-190377
Reactome Name: FGFR2b ligand binding and activation
See in Reactome
R-HSA-190375
R-HSA-190375
Reactome Name: FGFR2c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-109704
R-HSA-5654700
R-HSA-5654699
R-HSA-5654695
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5654738
R-HSA-74752
R-HSA-190241
R-HSA-190241
Reactome Name: FGFR2 ligand binding and activation
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-190236
R-HSA-5684996
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399;
R-HSA-74751
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190258
(
R-HSA-190375
)
R-HSA-190260
(
R-HSA-190377
)
R-HSA-190408
(
R-HSA-190377
)
R-HSA-190408
Reaction Name: Autocatalytic phosphorylation of FGFR2b
See in Reactome
R-HSA-190413
(
R-HSA-190375
)
R-HSA-190413
Reaction Name: Autocatalytic phosphorylation of FGFR2c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654147
(
R-HSA-5654221
)
R-HSA-5654147
Reaction Name: Activated FGFR2 phosphorylates PLCG1
See in Reactome
R-HSA-5654157
(
R-HSA-5654221
)
R-HSA-5654157
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR2
See in Reactome
R-HSA-5654159
(
R-HSA-5654221
)
R-HSA-5654397
(
R-HSA-5654700
)
R-HSA-5654397
Reaction Name: Activated FGFR2 phosphorylates FRS2
See in Reactome
R-HSA-5654399
(
R-HSA-5654700
)
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654404
(
R-HSA-5654699
)
R-HSA-5654406
(
R-HSA-5654699
)
R-HSA-5654406
Reaction Name: Activated FGFR2:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654407
(
R-HSA-5654699
)
R-HSA-5654407
Reaction Name: Activated FGFR2 phosphorylates SHC1
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654603
(
R-HSA-5654700
)
R-HSA-5654605
(
R-HSA-5654700
)
R-HSA-5654605
Reaction Name: Activated FGFR2 phosphorylates FRS3
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654612
(
R-HSA-5654695
)
R-HSA-5654612
Reaction Name: Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654615
(
R-HSA-5654700
)
R-HSA-5654615
Reaction Name: Activated FGFR2:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0007042 |
FGFR3 |
P22607 |
2.7.10.1
|
R-HSA-190372
R-HSA-190372
Reactome Name: FGFR3c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-5654227
R-HSA-5654227
Reactome Name: Phospholipase C-mediated cascade; FGFR3
See in Reactome
R-HSA-190371
R-HSA-190371
Reactome Name: FGFR3b ligand binding and activation
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654710
R-HSA-109704
R-HSA-5654706
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654704
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5684996
R-HSA-190239
R-HSA-190239
Reactome Name: FGFR3 ligand binding and activation
See in Reactome
R-HSA-190236
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-5654741
R-HSA-74752
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190261
(
R-HSA-190372
)
R-HSA-190263
(
R-HSA-190371
)
R-HSA-190385
(
R-HSA-190371
)
R-HSA-190385
Reaction Name: Autocatalytic phosphorylation of FGFR3b
See in Reactome
R-HSA-190388
(
R-HSA-190372
)
R-HSA-190388
Reaction Name: Autocatalytic phosphorylation of FGFR3c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654148
(
R-HSA-5654227
)
R-HSA-5654148
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR3
See in Reactome
R-HSA-5654222
(
R-HSA-5654227
)
R-HSA-5654222
Reaction Name: Activated FGFR3 phosphorylates PLCG1
See in Reactome
R-HSA-5654224
(
R-HSA-5654227
)
R-HSA-5654408
(
R-HSA-5654706
)
R-HSA-5654408
Reaction Name: Activated FGFR3 phosphorylates FRS2
See in Reactome
R-HSA-5654409
(
R-HSA-5654706
)
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654416
(
R-HSA-5654706
)
R-HSA-5654416
Reaction Name: Activated FGFR3:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654565
(
R-HSA-5654732
)
R-HSA-5654565
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2.
See in Reactome
R-HSA-5654623
(
R-HSA-5654706
)
R-HSA-5654625
(
R-HSA-5654704
)
R-HSA-5654628
(
R-HSA-5654706
)
R-HSA-5654628
Reaction Name: Activated FGFR3 phosphorylates FRS3
See in Reactome
R-HSA-5654631
(
R-HSA-5654706
)
R-HSA-5654631
Reaction Name: Activated FGFR3 phosphorylates PPTN11
See in Reactome
R-HSA-5654633
(
R-HSA-5654706
)
R-HSA-5654633
Reaction Name: Activated FGFR3:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654634
(
R-HSA-5654704
)
R-HSA-5654634
Reaction Name: Activated FGFR3 phosphorylates SHC1
See in Reactome
R-HSA-5654637
(
R-HSA-5654710
)
R-HSA-5654637
Reaction Name: Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654641
(
R-HSA-5654710
)
R-HSA-5654641
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654646
(
R-HSA-5654704
)
R-HSA-5654646
Reaction Name: Activated FGFR3:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654679
(
R-HSA-5654732
)
R-HSA-5654679
Reaction Name: CBL ubiquitinates FRS2 and FGFR3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654730
(
R-HSA-5654732
)
R-HSA-5654730
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0007154 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0007203 |
TEK |
Q02763 |
2.7.10.1
|
R-HSA-210993
R-HSA-5673001
|
R-HSA-109582
R-HSA-5684996
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-162582
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
|
Hemostasis
Signal Transduction
|
R-HSA-204773
(
R-HSA-210993
)
R-HSA-204779
(
R-HSA-210993
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-204813
(
R-HSA-210993
)
R-HSA-204824
(
R-HSA-210993
)
R-HSA-204850
(
R-HSA-210993
)
R-HSA-204861
(
R-HSA-210993
)
R-HSA-204863
(
R-HSA-210993
)
R-HSA-204871
(
R-HSA-210993
)
R-HSA-204873
(
R-HSA-210993
)
R-HSA-210872
(
R-HSA-210993
)
R-HSA-210881
(
R-HSA-210993
)
R-HSA-210881
Reaction Name: Dimerization of Tie2/Ang1 complex
See in Reactome
R-HSA-210974
(
R-HSA-210993
)
R-HSA-210974
Reaction Name: Interaction of SOS-1 to Tie2 bound Grb2
See in Reactome
R-HSA-210977
(
R-HSA-210993
)
R-HSA-210977
Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
|
MONDO:0007256 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0007265 |
KRAS |
P01116 |
3.6.5.2
|
R-HSA-171007
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-8951936
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-5674135
R-HSA-9027284
R-HSA-9607240
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-186763
R-HSA-442982
R-HSA-442982
Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor
See in Reactome
R-HSA-5673000
R-HSA-5673001
R-HSA-9648002
R-HSA-9026519
R-HSA-9026519
Reactome Name: Activated NTRK2 signals through RAS
See in Reactome
R-HSA-5654688
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-4086398
R-HSA-5654700
R-HSA-5654712
R-HSA-5654706
R-HSA-5654704
R-HSA-1169092
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-9034864
R-HSA-9034864
Reactome Name: Activated NTRK3 signals through RAS
See in Reactome
R-HSA-1433557
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-167044
R-HSA-2428933
R-HSA-2428933
Reactome Name: SHC-related events triggered by IGF1R
See in Reactome
R-HSA-2424491
R-HSA-180336
R-HSA-5654693
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-5658442
R-HSA-9674555
R-HSA-179812
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-8851805
R-HSA-5621575
R-HSA-112412
R-HSA-210993
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-2179392
R-HSA-2179392
Reactome Name: EGFR Transactivation by Gastrin
See in Reactome
R-HSA-5654719
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-5654699
|
R-HSA-186797
R-HSA-8848021
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-2428924
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-112399
R-HSA-74752
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-9675108
R-HSA-5684996
R-HSA-177929
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-112316
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-4420097
R-HSA-9006335
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-9034015
R-HSA-168249
R-HSA-187687
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-1280218
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-195721
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-416476
R-HSA-194138
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Gene expression (Transcription)
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-8951977
(
R-HSA-8951936
)
R-HSA-8951977
Reaction Name: Acetylated RUNX3 binds to BRD2
See in Reactome
R-HSA-9647977
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647977
Reaction Name: ICMT methylates S-Farn RAS proteins
See in Reactome
R-HSA-9647978
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647978
Reaction Name: pro-RAS proteins are farnesylated
See in Reactome
R-HSA-9647999
(
R-HSA-5673001;
R-HSA-9648002
)
R-HSA-9647999
Reaction Name: RCE1 cleaves S-Farn proRAS proteins
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
|
MONDO:0007400 |
FGFR1 |
P11362 |
2.7.10.1
|
R-HSA-445144
R-HSA-190374
R-HSA-190374
Reactome Name: FGFR1c and Klotho ligand binding and activation
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-1257604
R-HSA-190370
R-HSA-190370
Reactome Name: FGFR1b ligand binding and activation
See in Reactome
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-5654689
R-HSA-5654688
R-HSA-5673001
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-109704
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654219
R-HSA-5654219
Reactome Name: Phospholipase C-mediated cascade: FGFR1
See in Reactome
R-HSA-5654693
R-HSA-190373
R-HSA-190373
Reactome Name: FGFR1c ligand binding and activation
See in Reactome
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-373760
R-HSA-190236
R-HSA-190242
R-HSA-190242
Reactome Name: FGFR1 ligand binding and activation
See in Reactome
R-HSA-74752
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-9675108
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-162582
R-HSA-5654736
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5684996
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
Developmental Biology
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-74751
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190245
(
R-HSA-190370
)
R-HSA-190256
(
R-HSA-190373
)
R-HSA-190268
(
R-HSA-190374
)
R-HSA-190268
Reaction Name: FGFR1c binds to Klotho-bound FGF23
See in Reactome
R-HSA-190427
(
R-HSA-190370
)
R-HSA-190427
Reaction Name: Autocatalytic phosphorylation of FGFR1b
See in Reactome
R-HSA-190429
(
R-HSA-190373
)
R-HSA-190429
Reaction Name: Autocatalytic phosphorylation of FGFR1c
See in Reactome
R-HSA-191062
(
R-HSA-190374
)
R-HSA-191062
Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-419033
(
R-HSA-375165
)
R-HSA-437230
(
R-HSA-445144
)
R-HSA-5654149
(
R-HSA-5654219;
R-HSA-5654687
)
R-HSA-5654149
Reaction Name: Activated FGFR1 phosphorylates PLCG1
See in Reactome
R-HSA-5654165
(
R-HSA-5654219;
R-HSA-5654687
)
R-HSA-5654165
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1
See in Reactome
R-HSA-5654167
(
R-HSA-5654219;
R-HSA-5654687
)
R-HSA-5654392
(
R-HSA-5654687;
R-HSA-5654693
)
R-HSA-5654392
Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654514
(
R-HSA-5654726
)
R-HSA-5654560
(
R-HSA-5654726
)
R-HSA-5654560
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2.
See in Reactome
R-HSA-5654569
(
R-HSA-5654687;
R-HSA-5654693
)
R-HSA-5654571
(
R-HSA-5654687;
R-HSA-5654693
)
R-HSA-5654573
(
R-HSA-5654687;
R-HSA-5654688
)
R-HSA-5654575
(
R-HSA-5654687;
R-HSA-5654693
)
R-HSA-5654575
Reaction Name: Activated FGFR1 phosphorylates FRS2
See in Reactome
R-HSA-5654578
(
R-HSA-5654687;
R-HSA-5654693
)
R-HSA-5654578
Reaction Name: Activated FGFR1 phosphorylates FRS3
See in Reactome
R-HSA-5654582
(
R-HSA-5654687;
R-HSA-5654688
)
R-HSA-5654582
Reaction Name: Activated FGFR1 phosphorylates SHC1
See in Reactome
R-HSA-5654584
(
R-HSA-5654687;
R-HSA-5654693
)
R-HSA-5654584
Reaction Name: Activated FGFR1:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654586
(
R-HSA-5654687;
R-HSA-5654693
)
R-HSA-5654586
Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1
See in Reactome
R-HSA-5654587
(
R-HSA-5654687;
R-HSA-5654693
)
R-HSA-5654587
Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11
See in Reactome
R-HSA-5654591
(
R-HSA-5654687;
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654592
(
R-HSA-5654687;
R-HSA-5654689
)
R-HSA-5654592
Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654594
(
R-HSA-5654687;
R-HSA-5654689
)
R-HSA-5654594
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654596
(
R-HSA-5654687;
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654597
(
R-HSA-5654687;
R-HSA-5654688
)
R-HSA-5654597
Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654600
(
R-HSA-5654687;
R-HSA-5654688
)
R-HSA-5654600
Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654672
(
R-HSA-5654726
)
R-HSA-5654672
Reaction Name: CBL ubiquitinates FRS2 and FGFR1
See in Reactome
R-HSA-5654673
(
R-HSA-5654726
)
R-HSA-5654673
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1
See in Reactome
R-HSA-5654690
(
R-HSA-5654687;
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654687;
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5656064
(
R-HSA-5654687
)
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654687;
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0007400 |
FGFR2 |
P21802 |
2.7.10.1
|
R-HSA-5654221
R-HSA-5654221
Reactome Name: Phospholipase C-mediated cascade; FGFR2
See in Reactome
R-HSA-190377
R-HSA-190377
Reactome Name: FGFR2b ligand binding and activation
See in Reactome
R-HSA-190375
R-HSA-190375
Reactome Name: FGFR2c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-109704
R-HSA-5654700
R-HSA-5654699
R-HSA-5654695
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5654738
R-HSA-74752
R-HSA-190241
R-HSA-190241
Reactome Name: FGFR2 ligand binding and activation
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-190236
R-HSA-5684996
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399;
R-HSA-74751
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190258
(
R-HSA-190375
)
R-HSA-190260
(
R-HSA-190377
)
R-HSA-190408
(
R-HSA-190377
)
R-HSA-190408
Reaction Name: Autocatalytic phosphorylation of FGFR2b
See in Reactome
R-HSA-190413
(
R-HSA-190375
)
R-HSA-190413
Reaction Name: Autocatalytic phosphorylation of FGFR2c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654147
(
R-HSA-5654221
)
R-HSA-5654147
Reaction Name: Activated FGFR2 phosphorylates PLCG1
See in Reactome
R-HSA-5654157
(
R-HSA-5654221
)
R-HSA-5654157
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR2
See in Reactome
R-HSA-5654159
(
R-HSA-5654221
)
R-HSA-5654397
(
R-HSA-5654700
)
R-HSA-5654397
Reaction Name: Activated FGFR2 phosphorylates FRS2
See in Reactome
R-HSA-5654399
(
R-HSA-5654700
)
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654404
(
R-HSA-5654699
)
R-HSA-5654406
(
R-HSA-5654699
)
R-HSA-5654406
Reaction Name: Activated FGFR2:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654407
(
R-HSA-5654699
)
R-HSA-5654407
Reaction Name: Activated FGFR2 phosphorylates SHC1
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654603
(
R-HSA-5654700
)
R-HSA-5654605
(
R-HSA-5654700
)
R-HSA-5654605
Reaction Name: Activated FGFR2 phosphorylates FRS3
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654612
(
R-HSA-5654695
)
R-HSA-5654612
Reaction Name: Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654615
(
R-HSA-5654700
)
R-HSA-5654615
Reaction Name: Activated FGFR2:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0007405 |
FGFR2 |
P21802 |
2.7.10.1
|
R-HSA-5654221
R-HSA-5654221
Reactome Name: Phospholipase C-mediated cascade; FGFR2
See in Reactome
R-HSA-190377
R-HSA-190377
Reactome Name: FGFR2b ligand binding and activation
See in Reactome
R-HSA-190375
R-HSA-190375
Reactome Name: FGFR2c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-109704
R-HSA-5654700
R-HSA-5654699
R-HSA-5654695
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5654738
R-HSA-74752
R-HSA-190241
R-HSA-190241
Reactome Name: FGFR2 ligand binding and activation
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-190236
R-HSA-5684996
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399;
R-HSA-74751
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190258
(
R-HSA-190375
)
R-HSA-190260
(
R-HSA-190377
)
R-HSA-190408
(
R-HSA-190377
)
R-HSA-190408
Reaction Name: Autocatalytic phosphorylation of FGFR2b
See in Reactome
R-HSA-190413
(
R-HSA-190375
)
R-HSA-190413
Reaction Name: Autocatalytic phosphorylation of FGFR2c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654147
(
R-HSA-5654221
)
R-HSA-5654147
Reaction Name: Activated FGFR2 phosphorylates PLCG1
See in Reactome
R-HSA-5654157
(
R-HSA-5654221
)
R-HSA-5654157
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR2
See in Reactome
R-HSA-5654159
(
R-HSA-5654221
)
R-HSA-5654397
(
R-HSA-5654700
)
R-HSA-5654397
Reaction Name: Activated FGFR2 phosphorylates FRS2
See in Reactome
R-HSA-5654399
(
R-HSA-5654700
)
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654404
(
R-HSA-5654699
)
R-HSA-5654406
(
R-HSA-5654699
)
R-HSA-5654406
Reaction Name: Activated FGFR2:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654407
(
R-HSA-5654699
)
R-HSA-5654407
Reaction Name: Activated FGFR2 phosphorylates SHC1
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654603
(
R-HSA-5654700
)
R-HSA-5654605
(
R-HSA-5654700
)
R-HSA-5654605
Reaction Name: Activated FGFR2 phosphorylates FRS3
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654612
(
R-HSA-5654695
)
R-HSA-5654612
Reaction Name: Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654615
(
R-HSA-5654700
)
R-HSA-5654615
Reaction Name: Activated FGFR2:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0007405 |
FGFR3 |
P22607 |
2.7.10.1
|
R-HSA-190372
R-HSA-190372
Reactome Name: FGFR3c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-5654227
R-HSA-5654227
Reactome Name: Phospholipase C-mediated cascade; FGFR3
See in Reactome
R-HSA-190371
R-HSA-190371
Reactome Name: FGFR3b ligand binding and activation
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-5654710
R-HSA-109704
R-HSA-5654706
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654704
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5684996
R-HSA-190239
R-HSA-190239
Reactome Name: FGFR3 ligand binding and activation
See in Reactome
R-HSA-190236
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-5654741
R-HSA-74752
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190261
(
R-HSA-190372
)
R-HSA-190263
(
R-HSA-190371
)
R-HSA-190385
(
R-HSA-190371
)
R-HSA-190385
Reaction Name: Autocatalytic phosphorylation of FGFR3b
See in Reactome
R-HSA-190388
(
R-HSA-190372
)
R-HSA-190388
Reaction Name: Autocatalytic phosphorylation of FGFR3c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654148
(
R-HSA-5654227
)
R-HSA-5654148
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR3
See in Reactome
R-HSA-5654222
(
R-HSA-5654227
)
R-HSA-5654222
Reaction Name: Activated FGFR3 phosphorylates PLCG1
See in Reactome
R-HSA-5654224
(
R-HSA-5654227
)
R-HSA-5654408
(
R-HSA-5654706
)
R-HSA-5654408
Reaction Name: Activated FGFR3 phosphorylates FRS2
See in Reactome
R-HSA-5654409
(
R-HSA-5654706
)
R-HSA-5654413
(
R-HSA-5654706
)
R-HSA-5654413
Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654416
(
R-HSA-5654706
)
R-HSA-5654416
Reaction Name: Activated FGFR3:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654565
(
R-HSA-5654732
)
R-HSA-5654565
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2.
See in Reactome
R-HSA-5654623
(
R-HSA-5654706
)
R-HSA-5654625
(
R-HSA-5654704
)
R-HSA-5654628
(
R-HSA-5654706
)
R-HSA-5654628
Reaction Name: Activated FGFR3 phosphorylates FRS3
See in Reactome
R-HSA-5654631
(
R-HSA-5654706
)
R-HSA-5654631
Reaction Name: Activated FGFR3 phosphorylates PPTN11
See in Reactome
R-HSA-5654633
(
R-HSA-5654706
)
R-HSA-5654633
Reaction Name: Activated FGFR3:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654634
(
R-HSA-5654704
)
R-HSA-5654634
Reaction Name: Activated FGFR3 phosphorylates SHC1
See in Reactome
R-HSA-5654637
(
R-HSA-5654710
)
R-HSA-5654637
Reaction Name: Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654641
(
R-HSA-5654710
)
R-HSA-5654641
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654646
(
R-HSA-5654704
)
R-HSA-5654646
Reaction Name: Activated FGFR3:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654647
(
R-HSA-5654704
)
R-HSA-5654647
Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654679
(
R-HSA-5654732
)
R-HSA-5654679
Reaction Name: CBL ubiquitinates FRS2 and FGFR3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654730
(
R-HSA-5654732
)
R-HSA-5654730
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0007412 |
FGFR2 |
P21802 |
2.7.10.1
|
R-HSA-5654221
R-HSA-5654221
Reactome Name: Phospholipase C-mediated cascade; FGFR2
See in Reactome
R-HSA-190377
R-HSA-190377
Reactome Name: FGFR2b ligand binding and activation
See in Reactome
R-HSA-190375
R-HSA-190375
Reactome Name: FGFR2c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-109704
R-HSA-5654700
R-HSA-5654699
R-HSA-5654695
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5654738
R-HSA-74752
R-HSA-190241
R-HSA-190241
Reactome Name: FGFR2 ligand binding and activation
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-190236
R-HSA-5684996
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399;
R-HSA-74751
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190258
(
R-HSA-190375
)
R-HSA-190260
(
R-HSA-190377
)
R-HSA-190408
(
R-HSA-190377
)
R-HSA-190408
Reaction Name: Autocatalytic phosphorylation of FGFR2b
See in Reactome
R-HSA-190413
(
R-HSA-190375
)
R-HSA-190413
Reaction Name: Autocatalytic phosphorylation of FGFR2c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654147
(
R-HSA-5654221
)
R-HSA-5654147
Reaction Name: Activated FGFR2 phosphorylates PLCG1
See in Reactome
R-HSA-5654157
(
R-HSA-5654221
)
R-HSA-5654157
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR2
See in Reactome
R-HSA-5654159
(
R-HSA-5654221
)
R-HSA-5654397
(
R-HSA-5654700
)
R-HSA-5654397
Reaction Name: Activated FGFR2 phosphorylates FRS2
See in Reactome
R-HSA-5654399
(
R-HSA-5654700
)
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654404
(
R-HSA-5654699
)
R-HSA-5654406
(
R-HSA-5654699
)
R-HSA-5654406
Reaction Name: Activated FGFR2:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654407
(
R-HSA-5654699
)
R-HSA-5654407
Reaction Name: Activated FGFR2 phosphorylates SHC1
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654603
(
R-HSA-5654700
)
R-HSA-5654605
(
R-HSA-5654700
)
R-HSA-5654605
Reaction Name: Activated FGFR2 phosphorylates FRS3
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654612
(
R-HSA-5654695
)
R-HSA-5654612
Reaction Name: Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654615
(
R-HSA-5654700
)
R-HSA-5654615
Reaction Name: Activated FGFR2:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0007540 |
RET |
P07949 |
2.7.10.1
|
R-HSA-8853659
R-HSA-5673001
|
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-9675108
R-HSA-162582
R-HSA-422475
R-HSA-5684996
R-HSA-1266738
|
Signal Transduction
Developmental Biology
|
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8853734
(
R-HSA-8853659
)
R-HSA-8853734
Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1
See in Reactome
R-HSA-8853737
(
R-HSA-8853659
)
R-HSA-8853737
Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind SHC1
See in Reactome
R-HSA-8853745
(
R-HSA-8853659
)
R-HSA-8853753
(
R-HSA-8853659
)
R-HSA-8853753
Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10
See in Reactome
R-HSA-8853755
(
R-HSA-8853659
)
R-HSA-8853755
Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1
See in Reactome
R-HSA-8853762
(
R-HSA-8853659
)
R-HSA-8853774
(
R-HSA-8853659
)
R-HSA-8853774
Reaction Name: GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated
See in Reactome
R-HSA-8853789
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R-HSA-8853659
)
R-HSA-8853789
Reaction Name: GDNF,NRTN bind RET:GFRA1,GFRA2
See in Reactome
R-HSA-8853792
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R-HSA-8853659
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R-HSA-8853793
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R-HSA-8853659
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R-HSA-8853800
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R-HSA-8853659
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R-HSA-8853801
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R-HSA-8853659
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R-HSA-8854897
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R-HSA-8853659
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R-HSA-8854897
Reaction Name: p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2
See in Reactome
R-HSA-8854899
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R-HSA-8853659
)
R-HSA-8854899
Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1
See in Reactome
R-HSA-8854905
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R-HSA-8853659
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R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-8854908
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R-HSA-8853659
)
R-HSA-8854908
Reaction Name: PKA phosphorylates RET:GDNF:GFRA dimer
See in Reactome
R-HSA-8854981
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R-HSA-8853659
)
R-HSA-8854981
Reaction Name: SHC1 in the RET complex is phosphorylated
See in Reactome
R-HSA-8855508
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R-HSA-8853659
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R-HSA-8855508
Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
See in Reactome
R-HSA-8855564
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R-HSA-8853659
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R-HSA-8855564
Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind FRS2
See in Reactome
R-HSA-8855617
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R-HSA-8853659
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R-HSA-8855617
Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6
See in Reactome
R-HSA-8855747
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R-HSA-8853659
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R-HSA-8855747
Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP
See in Reactome
R-HSA-8855915
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R-HSA-8853659
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R-HSA-8855915
Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors
See in Reactome
R-HSA-8871226
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R-HSA-8853659
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R-HSA-8871227
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R-HSA-8853659
)
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MONDO:0007546 |
PDGFRB |
P09619 |
2.7.10.1
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R-HSA-186797
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-186763
R-HSA-1257604
R-HSA-5673001
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R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
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