MONDO:0000141 |
BUB1 |
O43683 |
2.7.11.1
|
R-HSA-5663220
R-HSA-2500257
R-HSA-2500257
Reactome Name: Resolution of Sister Chromatid Cohesion
See in Reactome
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-9648025
R-HSA-9648025
Reactome Name: EML4 and NUDC in mitotic spindle formation
See in Reactome
R-HSA-141444
R-HSA-141444
Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
See in Reactome
R-HSA-68877
|
R-HSA-195258
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-141424
R-HSA-141424
Reactome Name: Amplification of signal from the kinetochores
See in Reactome
R-HSA-194315
R-HSA-69620
R-HSA-68886
R-HSA-69278
R-HSA-68882
R-HSA-1640170
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-69618
R-HSA-162582
|
Cell Cycle
Signal Transduction
|
R-HSA-141409
(
R-HSA-141444
)
R-HSA-141422
(
R-HSA-141444
)
R-HSA-141422
Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1
See in Reactome
R-HSA-141431
(
R-HSA-141444
)
R-HSA-141431
Reaction Name: MAD2 associates with the Mad1 kinetochore complex
See in Reactome
R-HSA-141439
(
R-HSA-141444
)
R-HSA-141439
Reaction Name: Release of activated MAD2 from kinetochores
See in Reactome
R-HSA-1638803
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638803
Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres
See in Reactome
R-HSA-1638821
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638821
Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin
See in Reactome
R-HSA-2467809
(
R-HSA-2467813
)
R-HSA-2467809
Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin
See in Reactome
R-HSA-2467811
(
R-HSA-2467813
)
R-HSA-2467811
Reaction Name: Separation of sister chromatids
See in Reactome
R-HSA-2468287
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-2468287
Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres
See in Reactome
R-HSA-2484822
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-375302
(
R-HSA-68877
)
R-HSA-375302
Reaction Name: Kinetochore capture of astral microtubules
See in Reactome
R-HSA-5666129
(
R-HSA-5663220
)
R-HSA-5666129
Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores
See in Reactome
R-HSA-5666160
(
R-HSA-5663220
)
R-HSA-5666160
Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores
See in Reactome
R-HSA-5666169
(
R-HSA-5663220
)
R-HSA-5666169
Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
See in Reactome
R-HSA-9648114
(
R-HSA-68877;
R-HSA-9648025
)
R-HSA-9648114
Reaction Name: EML4 recruits NUDC to mitotic spindle
See in Reactome
|
MONDO:0002529 |
RAC1 |
P63000 |
3.6.5.2
|
R-HSA-376172
R-HSA-445144
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-9619229
R-HSA-9619229
Reactome Name: Activation of RAC1 downstream of NMDARs
See in Reactome
R-HSA-428540
R-HSA-428543
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-399954
R-HSA-399954
Reactome Name: Sema3A PAK dependent Axon repulsion
See in Reactome
R-HSA-9032845
R-HSA-9032845
Reactome Name: Activated NTRK2 signals through CDK5
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-6798695
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-193648
R-HSA-193648
Reactome Name: NRAGE signals death through JNK
See in Reactome
R-HSA-5625900
R-HSA-5625740
R-HSA-9032759
R-HSA-1257604
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-389359
R-HSA-5627123
R-HSA-399955
R-HSA-399955
Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
See in Reactome
R-HSA-5626467
R-HSA-4420097
R-HSA-5663220
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5687128
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1433557
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-2424491
R-HSA-9013149
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-8875555
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-3928664
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-8848021
R-HSA-1280218
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9675108
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-112316
R-HSA-8875878
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-373760
R-HSA-9032500
R-HSA-9032500
Reactome Name: Activated NTRK2 signals through FYN
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-168249
R-HSA-195258
R-HSA-199991
R-HSA-73887
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-2682334
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-5653656
R-HSA-6806834
R-HSA-195721
R-HSA-2172127
R-HSA-204998
R-HSA-204998
Reactome Name: Cell death signalling via NRAGE, NRIF and NADE
See in Reactome
R-HSA-373755
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Developmental Biology
Neuronal System
Vesicle-mediated transport
Hemostasis
Signal Transduction
|
R-HSA-1011598
(
R-HSA-983231
)
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1433415
(
R-HSA-1433557
)
R-HSA-2029451
(
R-HSA-2029482
)
R-HSA-2029454
(
R-HSA-2029482
)
R-HSA-2029456
(
R-HSA-2029482;
R-HSA-5627123
)
R-HSA-2029465
(
R-HSA-2029482;
R-HSA-4420097;
R-HSA-5663213
)
R-HSA-2029465
Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)
See in Reactome
R-HSA-2029466
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029466
Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin
See in Reactome
R-HSA-2029467
(
R-HSA-2029482
)
R-HSA-2029467
Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO
See in Reactome
R-HSA-2029469
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029469
Reaction Name: p-ERK phosphorylates WAVEs and ABI
See in Reactome
R-HSA-205039
(
R-HSA-193648
)
R-HSA-205039
Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
See in Reactome
R-HSA-205136
(
R-HSA-193648
)
R-HSA-205136
Reaction Name: GTP-bound RAC contributes to JNK activation
See in Reactome
R-HSA-2130194
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2197690
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2316352
(
R-HSA-1445148
)
R-HSA-2316352
Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424476
(
R-HSA-2424491
)
R-HSA-2730840
(
R-HSA-2871796
)
R-HSA-2730856
(
R-HSA-2871796
)
R-HSA-2730889
(
R-HSA-2871796
)
R-HSA-2730889
Reaction Name: Recruitment of PAK to the membrane by binding active RAC1
See in Reactome
R-HSA-376123
(
R-HSA-376172
)
R-HSA-376123
Reaction Name: DSCAM associates with Rac1-GTP:pPAK1
See in Reactome
R-HSA-3858475
(
R-HSA-4086400
)
R-HSA-389348
(
R-HSA-389359
)
R-HSA-389788
(
R-HSA-389359;
R-HSA-5687128
)
R-HSA-389788
Reaction Name: Activation of PAKs by RAC1 and CDC42
See in Reactome
R-HSA-3928612
(
R-HSA-3928662
)
R-HSA-3928612
Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928619
(
R-HSA-3928662
)
R-HSA-3928620
(
R-HSA-3928662
)
R-HSA-3928625
(
R-HSA-3928664
)
R-HSA-3928628
(
R-HSA-3928665
)
R-HSA-3928628
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928633
(
R-HSA-3928664
)
R-HSA-3928633
Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it
See in Reactome
R-HSA-3928640
(
R-HSA-3928664
)
R-HSA-3928641
(
R-HSA-3928664
)
R-HSA-3928642
(
R-HSA-3928665
)
R-HSA-3928642
Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-399928
(
R-HSA-399955
)
R-HSA-399928
Reaction Name: Recruitment of Rnd1 to Plexin A
See in Reactome
R-HSA-399930
(
R-HSA-399954
)
R-HSA-399935
(
R-HSA-399955
)
R-HSA-399935
Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity
See in Reactome
R-HSA-399938
(
R-HSA-399955
)
R-HSA-399939
(
R-HSA-399954
)
R-HSA-399941
(
R-HSA-399955
)
R-HSA-399952
(
R-HSA-399954
)
R-HSA-399952
Reaction Name: Phosphorylation of LIMK-1 by PAK
See in Reactome
R-HSA-400682
(
R-HSA-416550
)
R-HSA-400682
Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D
See in Reactome
R-HSA-4093336
(
R-HSA-3928662
)
R-HSA-4093336
Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-428522
(
R-HSA-428543
)
R-HSA-428535
(
R-HSA-428540
)
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442592
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-442592
Reaction Name: WASPs or WAVEs activate the ARP2/3 complex
See in Reactome
R-HSA-445064
(
R-HSA-445144
)
R-HSA-445072
(
R-HSA-445144
)
R-HSA-445072
Reaction Name: Interaction of PAK1 with Rac1-GTP
See in Reactome
R-HSA-451347
(
R-HSA-376172
)
R-HSA-451366
(
R-HSA-376172
)
R-HSA-5218827
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218827
Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1
See in Reactome
R-HSA-5218839
(
R-HSA-4420097
)
R-HSA-5218839
Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1
See in Reactome
R-HSA-5218841
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218841
Reaction Name: NADPH oxidase 2 generates superoxide from oxygen
See in Reactome
R-HSA-5218850
(
R-HSA-4420097
)
R-HSA-5218850
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-5357445
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357472
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357483
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5626469
(
R-HSA-5626467
)
R-HSA-5626469
Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs
See in Reactome
R-HSA-5626507
(
R-HSA-5626467
)
R-HSA-5626507
Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin
See in Reactome
R-HSA-5626549
(
R-HSA-5626467
)
R-HSA-5627775
(
R-HSA-5627123;
R-HSA-5687128
)
R-HSA-5627775
Reaction Name: Autophosphorylation of PAK1,2,3
See in Reactome
R-HSA-5663232
(
R-HSA-5663220
)
R-HSA-5665659
(
R-HSA-5663220
)
R-HSA-5665659
Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin
See in Reactome
R-HSA-5665802
(
R-HSA-5663220
)
R-HSA-5665802
Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin
See in Reactome
R-HSA-5665809
(
R-HSA-5663220
)
R-HSA-5665809
Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments
See in Reactome
R-HSA-5668714
(
R-HSA-5668599
)
R-HSA-5668718
(
R-HSA-5668599
)
R-HSA-5668718
Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen
See in Reactome
R-HSA-5668731
(
R-HSA-5668599
)
R-HSA-5668731
Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen
See in Reactome
R-HSA-5668735
(
R-HSA-5668599
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5672304
(
R-HSA-5626467
)
R-HSA-5672304
Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1
See in Reactome
R-HSA-5672329
(
R-HSA-5626467
)
R-HSA-5672329
Reaction Name: IQGAP1 binds CLIP1 and microtubules
See in Reactome
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8848618
(
R-HSA-8849471
)
R-HSA-8848618
Reaction Name: Activation of RAC1 by the PXN:CRK complex
See in Reactome
R-HSA-8875591
(
R-HSA-8875555
)
R-HSA-8951586
(
R-HSA-4420097
)
R-HSA-8951586
Reaction Name: p-VAV family:PIP3 binds RAC1:GDP
See in Reactome
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981926
(
R-HSA-5627123
)
R-HSA-8981931
(
R-HSA-5627123
)
R-HSA-9013143
(
R-HSA-9013149
)
R-HSA-9013144
(
R-HSA-9013149
)
R-HSA-9013144
Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9013147
(
R-HSA-9013149
)
R-HSA-9013147
Reaction Name: RAC1 GDIs block activation of RAC1
See in Reactome
R-HSA-9032798
(
R-HSA-9032759
)
R-HSA-9033292
(
R-HSA-9032845
)
R-HSA-9033292
Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1
See in Reactome
R-HSA-9619803
(
R-HSA-9619229
)
R-HSA-9691168
(
R-HSA-9013149
)
R-HSA-9691168
Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane
See in Reactome
R-HSA-9691174
(
R-HSA-9013149
)
R-HSA-9691174
Reaction Name: RAC1 binds effectors at the ER membrane
See in Reactome
|
MONDO:0005012 |
RAC1 |
P63000 |
3.6.5.2
|
R-HSA-376172
R-HSA-445144
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-9619229
R-HSA-9619229
Reactome Name: Activation of RAC1 downstream of NMDARs
See in Reactome
R-HSA-428540
R-HSA-428543
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-399954
R-HSA-399954
Reactome Name: Sema3A PAK dependent Axon repulsion
See in Reactome
R-HSA-9032845
R-HSA-9032845
Reactome Name: Activated NTRK2 signals through CDK5
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-6798695
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-193648
R-HSA-193648
Reactome Name: NRAGE signals death through JNK
See in Reactome
R-HSA-5625900
R-HSA-5625740
R-HSA-9032759
R-HSA-1257604
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-389359
R-HSA-5627123
R-HSA-399955
R-HSA-399955
Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
See in Reactome
R-HSA-5626467
R-HSA-4420097
R-HSA-5663220
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5687128
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1433557
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-2424491
R-HSA-9013149
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-8875555
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-3928664
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-8848021
R-HSA-1280218
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9675108
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-112316
R-HSA-8875878
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-373760
R-HSA-9032500
R-HSA-9032500
Reactome Name: Activated NTRK2 signals through FYN
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-168249
R-HSA-195258
R-HSA-199991
R-HSA-73887
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-2682334
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-5653656
R-HSA-6806834
R-HSA-195721
R-HSA-2172127
R-HSA-204998
R-HSA-204998
Reactome Name: Cell death signalling via NRAGE, NRIF and NADE
See in Reactome
R-HSA-373755
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Developmental Biology
Neuronal System
Vesicle-mediated transport
Hemostasis
Signal Transduction
|
R-HSA-1011598
(
R-HSA-983231
)
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1433415
(
R-HSA-1433557
)
R-HSA-2029451
(
R-HSA-2029482
)
R-HSA-2029454
(
R-HSA-2029482
)
R-HSA-2029456
(
R-HSA-2029482;
R-HSA-5627123
)
R-HSA-2029465
(
R-HSA-2029482;
R-HSA-4420097;
R-HSA-5663213
)
R-HSA-2029465
Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)
See in Reactome
R-HSA-2029466
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029466
Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin
See in Reactome
R-HSA-2029467
(
R-HSA-2029482
)
R-HSA-2029467
Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO
See in Reactome
R-HSA-2029469
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029469
Reaction Name: p-ERK phosphorylates WAVEs and ABI
See in Reactome
R-HSA-205039
(
R-HSA-193648
)
R-HSA-205039
Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
See in Reactome
R-HSA-205136
(
R-HSA-193648
)
R-HSA-205136
Reaction Name: GTP-bound RAC contributes to JNK activation
See in Reactome
R-HSA-2130194
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2197690
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2316352
(
R-HSA-1445148
)
R-HSA-2316352
Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424476
(
R-HSA-2424491
)
R-HSA-2730840
(
R-HSA-2871796
)
R-HSA-2730856
(
R-HSA-2871796
)
R-HSA-2730889
(
R-HSA-2871796
)
R-HSA-2730889
Reaction Name: Recruitment of PAK to the membrane by binding active RAC1
See in Reactome
R-HSA-376123
(
R-HSA-376172
)
R-HSA-376123
Reaction Name: DSCAM associates with Rac1-GTP:pPAK1
See in Reactome
R-HSA-3858475
(
R-HSA-4086400
)
R-HSA-389348
(
R-HSA-389359
)
R-HSA-389788
(
R-HSA-389359;
R-HSA-5687128
)
R-HSA-389788
Reaction Name: Activation of PAKs by RAC1 and CDC42
See in Reactome
R-HSA-3928612
(
R-HSA-3928662
)
R-HSA-3928612
Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928619
(
R-HSA-3928662
)
R-HSA-3928620
(
R-HSA-3928662
)
R-HSA-3928625
(
R-HSA-3928664
)
R-HSA-3928628
(
R-HSA-3928665
)
R-HSA-3928628
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928633
(
R-HSA-3928664
)
R-HSA-3928633
Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it
See in Reactome
R-HSA-3928640
(
R-HSA-3928664
)
R-HSA-3928641
(
R-HSA-3928664
)
R-HSA-3928642
(
R-HSA-3928665
)
R-HSA-3928642
Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-399928
(
R-HSA-399955
)
R-HSA-399928
Reaction Name: Recruitment of Rnd1 to Plexin A
See in Reactome
R-HSA-399930
(
R-HSA-399954
)
R-HSA-399935
(
R-HSA-399955
)
R-HSA-399935
Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity
See in Reactome
R-HSA-399938
(
R-HSA-399955
)
R-HSA-399939
(
R-HSA-399954
)
R-HSA-399941
(
R-HSA-399955
)
R-HSA-399952
(
R-HSA-399954
)
R-HSA-399952
Reaction Name: Phosphorylation of LIMK-1 by PAK
See in Reactome
R-HSA-400682
(
R-HSA-416550
)
R-HSA-400682
Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D
See in Reactome
R-HSA-4093336
(
R-HSA-3928662
)
R-HSA-4093336
Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-428522
(
R-HSA-428543
)
R-HSA-428535
(
R-HSA-428540
)
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442592
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-442592
Reaction Name: WASPs or WAVEs activate the ARP2/3 complex
See in Reactome
R-HSA-445064
(
R-HSA-445144
)
R-HSA-445072
(
R-HSA-445144
)
R-HSA-445072
Reaction Name: Interaction of PAK1 with Rac1-GTP
See in Reactome
R-HSA-451347
(
R-HSA-376172
)
R-HSA-451366
(
R-HSA-376172
)
R-HSA-5218827
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218827
Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1
See in Reactome
R-HSA-5218839
(
R-HSA-4420097
)
R-HSA-5218839
Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1
See in Reactome
R-HSA-5218841
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218841
Reaction Name: NADPH oxidase 2 generates superoxide from oxygen
See in Reactome
R-HSA-5218850
(
R-HSA-4420097
)
R-HSA-5218850
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-5357445
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357472
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357483
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5626469
(
R-HSA-5626467
)
R-HSA-5626469
Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs
See in Reactome
R-HSA-5626507
(
R-HSA-5626467
)
R-HSA-5626507
Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin
See in Reactome
R-HSA-5626549
(
R-HSA-5626467
)
R-HSA-5627775
(
R-HSA-5627123;
R-HSA-5687128
)
R-HSA-5627775
Reaction Name: Autophosphorylation of PAK1,2,3
See in Reactome
R-HSA-5663232
(
R-HSA-5663220
)
R-HSA-5665659
(
R-HSA-5663220
)
R-HSA-5665659
Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin
See in Reactome
R-HSA-5665802
(
R-HSA-5663220
)
R-HSA-5665802
Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin
See in Reactome
R-HSA-5665809
(
R-HSA-5663220
)
R-HSA-5665809
Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments
See in Reactome
R-HSA-5668714
(
R-HSA-5668599
)
R-HSA-5668718
(
R-HSA-5668599
)
R-HSA-5668718
Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen
See in Reactome
R-HSA-5668731
(
R-HSA-5668599
)
R-HSA-5668731
Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen
See in Reactome
R-HSA-5668735
(
R-HSA-5668599
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5672304
(
R-HSA-5626467
)
R-HSA-5672304
Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1
See in Reactome
R-HSA-5672329
(
R-HSA-5626467
)
R-HSA-5672329
Reaction Name: IQGAP1 binds CLIP1 and microtubules
See in Reactome
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8848618
(
R-HSA-8849471
)
R-HSA-8848618
Reaction Name: Activation of RAC1 by the PXN:CRK complex
See in Reactome
R-HSA-8875591
(
R-HSA-8875555
)
R-HSA-8951586
(
R-HSA-4420097
)
R-HSA-8951586
Reaction Name: p-VAV family:PIP3 binds RAC1:GDP
See in Reactome
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981926
(
R-HSA-5627123
)
R-HSA-8981931
(
R-HSA-5627123
)
R-HSA-9013143
(
R-HSA-9013149
)
R-HSA-9013144
(
R-HSA-9013149
)
R-HSA-9013144
Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9013147
(
R-HSA-9013149
)
R-HSA-9013147
Reaction Name: RAC1 GDIs block activation of RAC1
See in Reactome
R-HSA-9032798
(
R-HSA-9032759
)
R-HSA-9033292
(
R-HSA-9032845
)
R-HSA-9033292
Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1
See in Reactome
R-HSA-9619803
(
R-HSA-9619229
)
R-HSA-9691168
(
R-HSA-9013149
)
R-HSA-9691168
Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane
See in Reactome
R-HSA-9691174
(
R-HSA-9013149
)
R-HSA-9691174
Reaction Name: RAC1 binds effectors at the ER membrane
See in Reactome
|
MONDO:0005036 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0005061 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0005298 |
MONDO:0005298
Disease Name: osteoporosis
OMIM id: OMIM:166710
All associated enzymes in DAR:
SRC
. The disease is also associated to other non-enzyme proteins (not in DAR).
SRC |
P12931 |
2.7.10.2
|
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-171007
R-HSA-428542
R-HSA-428542
Reactome Name: Regulation of commissural axon pathfinding by SLIT and ROBO
See in Reactome
R-HSA-418594
R-HSA-8940973
R-HSA-8940973
Reactome Name: RUNX2 regulates osteoblast differentiation
See in Reactome
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-437239
R-HSA-418592
R-HSA-418592
Reactome Name: ADP signalling through P2Y purinoceptor 1
See in Reactome
R-HSA-430116
R-HSA-430116
Reactome Name: GP1b-IX-V activation signalling
See in Reactome
R-HSA-5663220
R-HSA-186763
R-HSA-180292
R-HSA-8941858
R-HSA-8941858
Reactome Name: Regulation of RUNX3 expression and activity
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-418555
R-HSA-5673000
R-HSA-9032500
R-HSA-9032500
Reactome Name: Activated NTRK2 signals through FYN
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-8934903
R-HSA-8853659
R-HSA-372708
R-HSA-372708
Reactome Name: p130Cas linkage to MAPK signaling for integrins
See in Reactome
R-HSA-389356
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-4420097
R-HSA-1433559
R-HSA-2029481
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-1433557
R-HSA-9620244
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-5607764
R-HSA-5674135
R-HSA-8874081
R-HSA-1253288
R-HSA-1253288
Reactome Name: Downregulation of ERBB4 signaling
See in Reactome
R-HSA-2682334
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-177929
R-HSA-1251985
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-354194
R-HSA-354194
Reactome Name: GRB2:SOS provides linkage to MAPK signaling for Integrins
See in Reactome
R-HSA-3928664
R-HSA-456926
R-HSA-456926
Reactome Name: Thrombin signalling through proteinase activated receptors (PARs)
See in Reactome
R-HSA-354192
R-HSA-201556
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-191650
R-HSA-191650
Reactome Name: Regulation of gap junction activity
See in Reactome
R-HSA-9013420
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-1227986
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-376176
R-HSA-9012999
R-HSA-8941326
R-HSA-8941326
Reactome Name: RUNX2 regulates bone development
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-195258
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-1640170
R-HSA-373760
R-HSA-5684996
R-HSA-1280218
R-HSA-1266738
R-HSA-5673001
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-9612973
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-5205647
R-HSA-388396
R-HSA-112316
R-HSA-162582
R-HSA-8875878
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-9675108
R-HSA-168249
R-HSA-9663891
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-392518
R-HSA-8939211
R-HSA-157858
R-HSA-157858
Reactome Name: Gap junction trafficking and regulation
See in Reactome
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-1236394
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-5653656
R-HSA-1632852
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-73857
R-HSA-5654736
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-9034015
R-HSA-186797
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-167044
R-HSA-373752
|
Immune System
Cell-Cell communication
Cell Cycle
Developmental Biology
Autophagy
Gene expression (Transcription)
Neuronal System
Signal Transduction
Vesicle-mediated transport
Hemostasis
|
R-HSA-1252013
(
R-HSA-1251985
)
R-HSA-1252013
Reaction Name: Translocation of ERBB4s80 to the nucleus
See in Reactome
R-HSA-177923
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-186819
(
R-HSA-186763
)
R-HSA-186819
Reaction Name: SH2 domain of Src binds to the active receptor
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-354066
(
R-HSA-354192
)
R-HSA-354066
Reaction Name: Translocation of PTK2 to Focal complexes
See in Reactome
R-HSA-354073
(
R-HSA-354192
)
R-HSA-354073
Reaction Name: Autophosphorylation of PTK2 at Y397
See in Reactome
R-HSA-354077
(
R-HSA-354192
)
R-HSA-354077
Reaction Name: Integrin alphaIIb beta3 activation
See in Reactome
R-HSA-354087
(
R-HSA-354192;
R-HSA-354194
)
R-HSA-354124
(
R-HSA-354192
)
R-HSA-354124
Reaction Name: Phosphorylation of pPTK2 by SRC
See in Reactome
R-HSA-354149
(
R-HSA-354192
)
R-HSA-354149
Reaction Name: Interaction of integrin alphaIIb beta3 with Fibrinogen
See in Reactome
R-HSA-354165
(
R-HSA-354192;
R-HSA-354194
)
R-HSA-354165
Reaction Name: Interaction of SOS with GRB2 bound to FADK1
See in Reactome
R-HSA-372693
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372693
Reaction Name: Phosphorylation of BCAR1 by SRC-PTK2 complex
See in Reactome
R-HSA-372697
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372705
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372705
Reaction Name: Recruitment of BCAR1 to PTK2 complex
See in Reactome
R-HSA-373716
(
R-HSA-418885
)
R-HSA-374701
(
R-HSA-418885
)
R-HSA-377640
(
R-HSA-354192
)
R-HSA-377641
(
R-HSA-354192
)
R-HSA-377641
Reaction Name: Clustering of Integrin alphaIIb beta3 complexes
See in Reactome
R-HSA-377643
(
R-HSA-354192
)
R-HSA-377643
Reaction Name: Dephosphorylation of inactive SRC by PTPB1
See in Reactome
R-HSA-377644
(
R-HSA-354192
)
R-HSA-380780
(
R-HSA-186763
)
R-HSA-418850
(
R-HSA-418885
)
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418858
(
R-HSA-418885
)
R-HSA-418858
Reaction Name: RhoGTPase GEF's recruited to DCC
See in Reactome
R-HSA-418859
(
R-HSA-418886
)
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-418868
(
R-HSA-418885
)
R-HSA-418868
Reaction Name: Recruitment of Src and Fyn to DCC:FADK1
See in Reactome
R-HSA-418874
(
R-HSA-418885
)
R-HSA-418874
Reaction Name: Recruitment and activation of N-WASP by Cdc42
See in Reactome
R-HSA-429415
(
R-HSA-354192
)
R-HSA-429415
Reaction Name: SYK binds to integrin alphaIIb beta3
See in Reactome
R-HSA-429441
(
R-HSA-354192
)
R-HSA-432096
(
R-HSA-354192
)
R-HSA-432096
Reaction Name: Activated integrin alphaIIb beta3 binds SHC1
See in Reactome
R-HSA-443905
(
R-HSA-354192
)
R-HSA-443905
Reaction Name: SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow
See in Reactome
R-HSA-443910
(
R-HSA-354192
)
R-HSA-443910
Reaction Name: SHC1 dissociates from integrin alphaIIb beta3
See in Reactome
R-HSA-5672969
(
R-HSA-5673000
)
R-HSA-5672972
(
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-8874080
(
R-HSA-8874081
)
R-HSA-8874082
(
R-HSA-8874081
)
R-HSA-8874083
(
R-HSA-8874081
)
R-HSA-8937682
(
R-HSA-8934593
)
R-HSA-8937728
(
R-HSA-8934593
)
R-HSA-8937792
(
R-HSA-8941858
)
R-HSA-8937807
(
R-HSA-8941858
)
R-HSA-8937814
(
R-HSA-8941858
)
R-HSA-8937814
Reaction Name: RUNX3 translocates to the nucleus
See in Reactome
R-HSA-8937820
(
R-HSA-8940973
)
R-HSA-8937844
(
R-HSA-8940973
)
R-HSA-8964242
(
R-HSA-418594
)
R-HSA-8964242
Reaction Name: G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC
See in Reactome
R-HSA-8964252
(
R-HSA-418555
)
R-HSA-8964252
Reaction Name: G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC
See in Reactome
R-HSA-8964278
(
R-HSA-418555
)
R-HSA-8964278
Reaction Name: G protein alpha (s):GTP binds SRC
See in Reactome
R-HSA-8964287
(
R-HSA-418555
)
R-HSA-8964287
Reaction Name: G alpha (s):GTP:SRC dissociates
See in Reactome
R-HSA-8964311
(
R-HSA-418594
)
R-HSA-8964329
(
R-HSA-418594
)
R-HSA-8964329
Reaction Name: G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC
See in Reactome
R-HSA-9011241
(
R-HSA-428542
)
R-HSA-9011241
Reaction Name: SRC phosphorylates ROBO3.1 in response to NTN1
See in Reactome
R-HSA-9021596
(
R-HSA-9009391
)
R-HSA-9021596
Reaction Name: Membrane estrogen receptors bind SRC
See in Reactome
R-HSA-9021609
(
R-HSA-9009391
)
R-HSA-9021609
Reaction Name: ESR-associated SRC autophosphorylates
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9037040
(
R-HSA-9032500
)
R-HSA-9603419
(
R-HSA-9603381
)
R-HSA-9603420
(
R-HSA-9603381
)
R-HSA-9603420
Reaction Name: Activated NTRK3 promotes SRC autophosphorylation
See in Reactome
R-HSA-9603437
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9612085
(
R-HSA-9620244
)
R-HSA-9612085
Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs
See in Reactome
R-HSA-9612219
(
R-HSA-1253288
)
R-HSA-9624014
(
R-HSA-418555
)
R-HSA-9624014
Reaction Name: SHC1 is phosphorylated downstream of estrogen stimulation of GPER1
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9657599
(
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9726848
(
R-HSA-9013420
)
|
MONDO:0005335 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
BUB1 |
O43683 |
2.7.11.1
|
R-HSA-5663220
R-HSA-2500257
R-HSA-2500257
Reactome Name: Resolution of Sister Chromatid Cohesion
See in Reactome
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-9648025
R-HSA-9648025
Reactome Name: EML4 and NUDC in mitotic spindle formation
See in Reactome
R-HSA-141444
R-HSA-141444
Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
See in Reactome
R-HSA-68877
|
R-HSA-195258
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-141424
R-HSA-141424
Reactome Name: Amplification of signal from the kinetochores
See in Reactome
R-HSA-194315
R-HSA-69620
R-HSA-68886
R-HSA-69278
R-HSA-68882
R-HSA-1640170
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-69618
R-HSA-162582
|
Cell Cycle
Signal Transduction
|
R-HSA-141409
(
R-HSA-141444
)
R-HSA-141422
(
R-HSA-141444
)
R-HSA-141422
Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1
See in Reactome
R-HSA-141431
(
R-HSA-141444
)
R-HSA-141431
Reaction Name: MAD2 associates with the Mad1 kinetochore complex
See in Reactome
R-HSA-141439
(
R-HSA-141444
)
R-HSA-141439
Reaction Name: Release of activated MAD2 from kinetochores
See in Reactome
R-HSA-1638803
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638803
Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres
See in Reactome
R-HSA-1638821
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638821
Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin
See in Reactome
R-HSA-2467809
(
R-HSA-2467813
)
R-HSA-2467809
Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin
See in Reactome
R-HSA-2467811
(
R-HSA-2467813
)
R-HSA-2467811
Reaction Name: Separation of sister chromatids
See in Reactome
R-HSA-2468287
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-2468287
Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres
See in Reactome
R-HSA-2484822
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-375302
(
R-HSA-68877
)
R-HSA-375302
Reaction Name: Kinetochore capture of astral microtubules
See in Reactome
R-HSA-5666129
(
R-HSA-5663220
)
R-HSA-5666129
Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores
See in Reactome
R-HSA-5666160
(
R-HSA-5663220
)
R-HSA-5666160
Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores
See in Reactome
R-HSA-5666169
(
R-HSA-5663220
)
R-HSA-5666169
Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
See in Reactome
R-HSA-9648114
(
R-HSA-68877;
R-HSA-9648025
)
R-HSA-9648114
Reaction Name: EML4 recruits NUDC to mitotic spindle
See in Reactome
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
BUB1B |
O60566 |
2.7.11.1
|
R-HSA-5663220
R-HSA-2500257
R-HSA-2500257
Reactome Name: Resolution of Sister Chromatid Cohesion
See in Reactome
R-HSA-176409
R-HSA-176409
Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-9648025
R-HSA-9648025
Reactome Name: EML4 and NUDC in mitotic spindle formation
See in Reactome
R-HSA-141430
R-HSA-141430
Reactome Name: Inactivation of APC/C via direct inhibition of the APC/C complex
See in Reactome
R-HSA-179409
R-HSA-179409
Reactome Name: APC-Cdc20 mediated degradation of Nek2A
See in Reactome
R-HSA-174184
R-HSA-174184
Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A
See in Reactome
R-HSA-141444
R-HSA-141444
Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
See in Reactome
R-HSA-68877
|
R-HSA-174143
R-HSA-174143
Reactome Name: APC/C-mediated degradation of cell cycle proteins
See in Reactome
R-HSA-195258
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-176408
R-HSA-176408
Reactome Name: Regulation of APC/C activators between G1/S and early anaphase
See in Reactome
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-176814
R-HSA-176814
Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-141424
R-HSA-141424
Reactome Name: Amplification of signal from the kinetochores
See in Reactome
R-HSA-194315
R-HSA-453276
R-HSA-453276
Reactome Name: Regulation of mitotic cell cycle
See in Reactome
R-HSA-69620
R-HSA-68886
R-HSA-69278
R-HSA-68882
R-HSA-179419
R-HSA-179419
Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
See in Reactome
R-HSA-1640170
R-HSA-141405
R-HSA-141405
Reactome Name: Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
See in Reactome
R-HSA-69618
R-HSA-162582
|
Cell Cycle
Signal Transduction
|
R-HSA-141409
(
R-HSA-141444
)
R-HSA-141422
(
R-HSA-141444
)
R-HSA-141422
Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1
See in Reactome
R-HSA-141423
(
R-HSA-141430
)
R-HSA-141423
Reaction Name: Binding of the MCC complex to the APC/C complex
See in Reactome
R-HSA-141431
(
R-HSA-141444
)
R-HSA-141431
Reaction Name: MAD2 associates with the Mad1 kinetochore complex
See in Reactome
R-HSA-141437
(
R-HSA-141430
)
R-HSA-141439
(
R-HSA-141444
)
R-HSA-141439
Reaction Name: Release of activated MAD2 from kinetochores
See in Reactome
R-HSA-1638803
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638803
Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres
See in Reactome
R-HSA-1638821
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638821
Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin
See in Reactome
R-HSA-174104
(
R-HSA-174184;
R-HSA-176409
)
R-HSA-174104
Reaction Name: Ubiquitination of Cyclin A by APC/C:Cdc20 complex
See in Reactome
R-HSA-174171
(
R-HSA-174184;
R-HSA-176409
)
R-HSA-174171
Reaction Name: Association of Cyclin A with the APC/C
See in Reactome
R-HSA-174238
(
R-HSA-176409
)
R-HSA-174238
Reaction Name: Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1
See in Reactome
R-HSA-174255
(
R-HSA-174184;
R-HSA-176409
)
R-HSA-174255
Reaction Name: Degradation multiubiquitinated Cyclin A
See in Reactome
R-HSA-179410
(
R-HSA-176409;
R-HSA-179409
)
R-HSA-179410
Reaction Name: Association of Nek2A with MCC:APC/C
See in Reactome
R-HSA-179417
(
R-HSA-176409;
R-HSA-179409
)
R-HSA-179421
(
R-HSA-176409;
R-HSA-179409
)
R-HSA-179421
Reaction Name: Degradation of multiubiquitinated Nek2A
See in Reactome
R-HSA-2467809
(
R-HSA-2467813
)
R-HSA-2467809
Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin
See in Reactome
R-HSA-2467811
(
R-HSA-2467813
)
R-HSA-2467811
Reaction Name: Separation of sister chromatids
See in Reactome
R-HSA-2468287
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-2468287
Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres
See in Reactome
R-HSA-2484822
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-375302
(
R-HSA-68877
)
R-HSA-375302
Reaction Name: Kinetochore capture of astral microtubules
See in Reactome
R-HSA-5666129
(
R-HSA-5663220
)
R-HSA-5666129
Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores
See in Reactome
R-HSA-5666160
(
R-HSA-5663220
)
R-HSA-5666160
Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores
See in Reactome
R-HSA-5666169
(
R-HSA-5663220
)
R-HSA-5666169
Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
See in Reactome
R-HSA-9648114
(
R-HSA-68877;
R-HSA-9648025
)
R-HSA-9648114
Reaction Name: EML4 recruits NUDC to mitotic spindle
See in Reactome
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
SRC |
P12931 |
2.7.10.2
|
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-171007
R-HSA-428542
R-HSA-428542
Reactome Name: Regulation of commissural axon pathfinding by SLIT and ROBO
See in Reactome
R-HSA-418594
R-HSA-8940973
R-HSA-8940973
Reactome Name: RUNX2 regulates osteoblast differentiation
See in Reactome
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-437239
R-HSA-418592
R-HSA-418592
Reactome Name: ADP signalling through P2Y purinoceptor 1
See in Reactome
R-HSA-430116
R-HSA-430116
Reactome Name: GP1b-IX-V activation signalling
See in Reactome
R-HSA-5663220
R-HSA-186763
R-HSA-180292
R-HSA-8941858
R-HSA-8941858
Reactome Name: Regulation of RUNX3 expression and activity
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-418555
R-HSA-5673000
R-HSA-9032500
R-HSA-9032500
Reactome Name: Activated NTRK2 signals through FYN
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-8934903
R-HSA-8853659
R-HSA-372708
R-HSA-372708
Reactome Name: p130Cas linkage to MAPK signaling for integrins
See in Reactome
R-HSA-389356
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-4420097
R-HSA-1433559
R-HSA-2029481
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-1433557
R-HSA-9620244
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-5607764
R-HSA-5674135
R-HSA-8874081
R-HSA-1253288
R-HSA-1253288
Reactome Name: Downregulation of ERBB4 signaling
See in Reactome
R-HSA-2682334
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-177929
R-HSA-1251985
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-354194
R-HSA-354194
Reactome Name: GRB2:SOS provides linkage to MAPK signaling for Integrins
See in Reactome
R-HSA-3928664
R-HSA-456926
R-HSA-456926
Reactome Name: Thrombin signalling through proteinase activated receptors (PARs)
See in Reactome
R-HSA-354192
R-HSA-201556
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-191650
R-HSA-191650
Reactome Name: Regulation of gap junction activity
See in Reactome
R-HSA-9013420
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-1227986
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-376176
R-HSA-9012999
R-HSA-8941326
R-HSA-8941326
Reactome Name: RUNX2 regulates bone development
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-195258
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-1640170
R-HSA-373760
R-HSA-5684996
R-HSA-1280218
R-HSA-1266738
R-HSA-5673001
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-9612973
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-5205647
R-HSA-388396
R-HSA-112316
R-HSA-162582
R-HSA-8875878
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-9675108
R-HSA-168249
R-HSA-9663891
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-392518
R-HSA-8939211
R-HSA-157858
R-HSA-157858
Reactome Name: Gap junction trafficking and regulation
See in Reactome
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-1236394
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-5653656
R-HSA-1632852
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-73857
R-HSA-5654736
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-9034015
R-HSA-186797
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-167044
R-HSA-373752
|
Immune System
Cell-Cell communication
Cell Cycle
Developmental Biology
Autophagy
Gene expression (Transcription)
Neuronal System
Signal Transduction
Vesicle-mediated transport
Hemostasis
|
R-HSA-1252013
(
R-HSA-1251985
)
R-HSA-1252013
Reaction Name: Translocation of ERBB4s80 to the nucleus
See in Reactome
R-HSA-177923
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-186819
(
R-HSA-186763
)
R-HSA-186819
Reaction Name: SH2 domain of Src binds to the active receptor
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-354066
(
R-HSA-354192
)
R-HSA-354066
Reaction Name: Translocation of PTK2 to Focal complexes
See in Reactome
R-HSA-354073
(
R-HSA-354192
)
R-HSA-354073
Reaction Name: Autophosphorylation of PTK2 at Y397
See in Reactome
R-HSA-354077
(
R-HSA-354192
)
R-HSA-354077
Reaction Name: Integrin alphaIIb beta3 activation
See in Reactome
R-HSA-354087
(
R-HSA-354192;
R-HSA-354194
)
R-HSA-354124
(
R-HSA-354192
)
R-HSA-354124
Reaction Name: Phosphorylation of pPTK2 by SRC
See in Reactome
R-HSA-354149
(
R-HSA-354192
)
R-HSA-354149
Reaction Name: Interaction of integrin alphaIIb beta3 with Fibrinogen
See in Reactome
R-HSA-354165
(
R-HSA-354192;
R-HSA-354194
)
R-HSA-354165
Reaction Name: Interaction of SOS with GRB2 bound to FADK1
See in Reactome
R-HSA-372693
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372693
Reaction Name: Phosphorylation of BCAR1 by SRC-PTK2 complex
See in Reactome
R-HSA-372697
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372705
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372705
Reaction Name: Recruitment of BCAR1 to PTK2 complex
See in Reactome
R-HSA-373716
(
R-HSA-418885
)
R-HSA-374701
(
R-HSA-418885
)
R-HSA-377640
(
R-HSA-354192
)
R-HSA-377641
(
R-HSA-354192
)
R-HSA-377641
Reaction Name: Clustering of Integrin alphaIIb beta3 complexes
See in Reactome
R-HSA-377643
(
R-HSA-354192
)
R-HSA-377643
Reaction Name: Dephosphorylation of inactive SRC by PTPB1
See in Reactome
R-HSA-377644
(
R-HSA-354192
)
R-HSA-380780
(
R-HSA-186763
)
R-HSA-418850
(
R-HSA-418885
)
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418858
(
R-HSA-418885
)
R-HSA-418858
Reaction Name: RhoGTPase GEF's recruited to DCC
See in Reactome
R-HSA-418859
(
R-HSA-418886
)
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-418868
(
R-HSA-418885
)
R-HSA-418868
Reaction Name: Recruitment of Src and Fyn to DCC:FADK1
See in Reactome
R-HSA-418874
(
R-HSA-418885
)
R-HSA-418874
Reaction Name: Recruitment and activation of N-WASP by Cdc42
See in Reactome
R-HSA-429415
(
R-HSA-354192
)
R-HSA-429415
Reaction Name: SYK binds to integrin alphaIIb beta3
See in Reactome
R-HSA-429441
(
R-HSA-354192
)
R-HSA-432096
(
R-HSA-354192
)
R-HSA-432096
Reaction Name: Activated integrin alphaIIb beta3 binds SHC1
See in Reactome
R-HSA-443905
(
R-HSA-354192
)
R-HSA-443905
Reaction Name: SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow
See in Reactome
R-HSA-443910
(
R-HSA-354192
)
R-HSA-443910
Reaction Name: SHC1 dissociates from integrin alphaIIb beta3
See in Reactome
R-HSA-5672969
(
R-HSA-5673000
)
R-HSA-5672972
(
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-8874080
(
R-HSA-8874081
)
R-HSA-8874082
(
R-HSA-8874081
)
R-HSA-8874083
(
R-HSA-8874081
)
R-HSA-8937682
(
R-HSA-8934593
)
R-HSA-8937728
(
R-HSA-8934593
)
R-HSA-8937792
(
R-HSA-8941858
)
R-HSA-8937807
(
R-HSA-8941858
)
R-HSA-8937814
(
R-HSA-8941858
)
R-HSA-8937814
Reaction Name: RUNX3 translocates to the nucleus
See in Reactome
R-HSA-8937820
(
R-HSA-8940973
)
R-HSA-8937844
(
R-HSA-8940973
)
R-HSA-8964242
(
R-HSA-418594
)
R-HSA-8964242
Reaction Name: G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC
See in Reactome
R-HSA-8964252
(
R-HSA-418555
)
R-HSA-8964252
Reaction Name: G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC
See in Reactome
R-HSA-8964278
(
R-HSA-418555
)
R-HSA-8964278
Reaction Name: G protein alpha (s):GTP binds SRC
See in Reactome
R-HSA-8964287
(
R-HSA-418555
)
R-HSA-8964287
Reaction Name: G alpha (s):GTP:SRC dissociates
See in Reactome
R-HSA-8964311
(
R-HSA-418594
)
R-HSA-8964329
(
R-HSA-418594
)
R-HSA-8964329
Reaction Name: G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC
See in Reactome
R-HSA-9011241
(
R-HSA-428542
)
R-HSA-9011241
Reaction Name: SRC phosphorylates ROBO3.1 in response to NTN1
See in Reactome
R-HSA-9021596
(
R-HSA-9009391
)
R-HSA-9021596
Reaction Name: Membrane estrogen receptors bind SRC
See in Reactome
R-HSA-9021609
(
R-HSA-9009391
)
R-HSA-9021609
Reaction Name: ESR-associated SRC autophosphorylates
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9037040
(
R-HSA-9032500
)
R-HSA-9603419
(
R-HSA-9603381
)
R-HSA-9603420
(
R-HSA-9603381
)
R-HSA-9603420
Reaction Name: Activated NTRK3 promotes SRC autophosphorylation
See in Reactome
R-HSA-9603437
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9612085
(
R-HSA-9620244
)
R-HSA-9612085
Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs
See in Reactome
R-HSA-9612219
(
R-HSA-1253288
)
R-HSA-9624014
(
R-HSA-418555
)
R-HSA-9624014
Reaction Name: SHC1 is phosphorylated downstream of estrogen stimulation of GPER1
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9657599
(
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9726848
(
R-HSA-9013420
)
|
MONDO:0008304 |
BUB1B |
O60566 |
2.7.11.1
|
R-HSA-5663220
R-HSA-2500257
R-HSA-2500257
Reactome Name: Resolution of Sister Chromatid Cohesion
See in Reactome
R-HSA-176409
R-HSA-176409
Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-9648025
R-HSA-9648025
Reactome Name: EML4 and NUDC in mitotic spindle formation
See in Reactome
R-HSA-141430
R-HSA-141430
Reactome Name: Inactivation of APC/C via direct inhibition of the APC/C complex
See in Reactome
R-HSA-179409
R-HSA-179409
Reactome Name: APC-Cdc20 mediated degradation of Nek2A
See in Reactome
R-HSA-174184
R-HSA-174184
Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A
See in Reactome
R-HSA-141444
R-HSA-141444
Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
See in Reactome
R-HSA-68877
|
R-HSA-174143
R-HSA-174143
Reactome Name: APC/C-mediated degradation of cell cycle proteins
See in Reactome
R-HSA-195258
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-176408
R-HSA-176408
Reactome Name: Regulation of APC/C activators between G1/S and early anaphase
See in Reactome
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-176814
R-HSA-176814
Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-141424
R-HSA-141424
Reactome Name: Amplification of signal from the kinetochores
See in Reactome
R-HSA-194315
R-HSA-453276
R-HSA-453276
Reactome Name: Regulation of mitotic cell cycle
See in Reactome
R-HSA-69620
R-HSA-68886
R-HSA-69278
R-HSA-68882
R-HSA-179419
R-HSA-179419
Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
See in Reactome
R-HSA-1640170
R-HSA-141405
R-HSA-141405
Reactome Name: Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
See in Reactome
R-HSA-69618
R-HSA-162582
|
Cell Cycle
Signal Transduction
|
R-HSA-141409
(
R-HSA-141444
)
R-HSA-141422
(
R-HSA-141444
)
R-HSA-141422
Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1
See in Reactome
R-HSA-141423
(
R-HSA-141430
)
R-HSA-141423
Reaction Name: Binding of the MCC complex to the APC/C complex
See in Reactome
R-HSA-141431
(
R-HSA-141444
)
R-HSA-141431
Reaction Name: MAD2 associates with the Mad1 kinetochore complex
See in Reactome
R-HSA-141437
(
R-HSA-141430
)
R-HSA-141439
(
R-HSA-141444
)
R-HSA-141439
Reaction Name: Release of activated MAD2 from kinetochores
See in Reactome
R-HSA-1638803
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638803
Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres
See in Reactome
R-HSA-1638821
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638821
Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin
See in Reactome
R-HSA-174104
(
R-HSA-174184;
R-HSA-176409
)
R-HSA-174104
Reaction Name: Ubiquitination of Cyclin A by APC/C:Cdc20 complex
See in Reactome
R-HSA-174171
(
R-HSA-174184;
R-HSA-176409
)
R-HSA-174171
Reaction Name: Association of Cyclin A with the APC/C
See in Reactome
R-HSA-174238
(
R-HSA-176409
)
R-HSA-174238
Reaction Name: Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1
See in Reactome
R-HSA-174255
(
R-HSA-174184;
R-HSA-176409
)
R-HSA-174255
Reaction Name: Degradation multiubiquitinated Cyclin A
See in Reactome
R-HSA-179410
(
R-HSA-176409;
R-HSA-179409
)
R-HSA-179410
Reaction Name: Association of Nek2A with MCC:APC/C
See in Reactome
R-HSA-179417
(
R-HSA-176409;
R-HSA-179409
)
R-HSA-179421
(
R-HSA-176409;
R-HSA-179409
)
R-HSA-179421
Reaction Name: Degradation of multiubiquitinated Nek2A
See in Reactome
R-HSA-2467809
(
R-HSA-2467813
)
R-HSA-2467809
Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin
See in Reactome
R-HSA-2467811
(
R-HSA-2467813
)
R-HSA-2467811
Reaction Name: Separation of sister chromatids
See in Reactome
R-HSA-2468287
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-2468287
Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres
See in Reactome
R-HSA-2484822
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-375302
(
R-HSA-68877
)
R-HSA-375302
Reaction Name: Kinetochore capture of astral microtubules
See in Reactome
R-HSA-5666129
(
R-HSA-5663220
)
R-HSA-5666129
Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores
See in Reactome
R-HSA-5666160
(
R-HSA-5663220
)
R-HSA-5666160
Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores
See in Reactome
R-HSA-5666169
(
R-HSA-5663220
)
R-HSA-5666169
Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
See in Reactome
R-HSA-9648114
(
R-HSA-68877;
R-HSA-9648025
)
R-HSA-9648114
Reaction Name: EML4 recruits NUDC to mitotic spindle
See in Reactome
|
MONDO:0009692 |
SRC |
P12931 |
2.7.10.2
|
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-171007
R-HSA-428542
R-HSA-428542
Reactome Name: Regulation of commissural axon pathfinding by SLIT and ROBO
See in Reactome
R-HSA-418594
R-HSA-8940973
R-HSA-8940973
Reactome Name: RUNX2 regulates osteoblast differentiation
See in Reactome
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-437239
R-HSA-418592
R-HSA-418592
Reactome Name: ADP signalling through P2Y purinoceptor 1
See in Reactome
R-HSA-430116
R-HSA-430116
Reactome Name: GP1b-IX-V activation signalling
See in Reactome
R-HSA-5663220
R-HSA-186763
R-HSA-180292
R-HSA-8941858
R-HSA-8941858
Reactome Name: Regulation of RUNX3 expression and activity
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-418555
R-HSA-5673000
R-HSA-9032500
R-HSA-9032500
Reactome Name: Activated NTRK2 signals through FYN
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-8934903
R-HSA-8853659
R-HSA-372708
R-HSA-372708
Reactome Name: p130Cas linkage to MAPK signaling for integrins
See in Reactome
R-HSA-389356
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-4420097
R-HSA-1433559
R-HSA-2029481
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-1433557
R-HSA-9620244
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-5607764
R-HSA-5674135
R-HSA-8874081
R-HSA-1253288
R-HSA-1253288
Reactome Name: Downregulation of ERBB4 signaling
See in Reactome
R-HSA-2682334
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-177929
R-HSA-1251985
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-354194
R-HSA-354194
Reactome Name: GRB2:SOS provides linkage to MAPK signaling for Integrins
See in Reactome
R-HSA-3928664
R-HSA-456926
R-HSA-456926
Reactome Name: Thrombin signalling through proteinase activated receptors (PARs)
See in Reactome
R-HSA-354192
R-HSA-201556
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-191650
R-HSA-191650
Reactome Name: Regulation of gap junction activity
See in Reactome
R-HSA-9013420
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-1227986
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-376176
R-HSA-9012999
R-HSA-8941326
R-HSA-8941326
Reactome Name: RUNX2 regulates bone development
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-195258
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-1640170
R-HSA-373760
R-HSA-5684996
R-HSA-1280218
R-HSA-1266738
R-HSA-5673001
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-9612973
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-5205647
R-HSA-388396
R-HSA-112316
R-HSA-162582
R-HSA-8875878
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-9675108
R-HSA-168249
R-HSA-9663891
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-392518
R-HSA-8939211
R-HSA-157858
R-HSA-157858
Reactome Name: Gap junction trafficking and regulation
See in Reactome
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-1236394
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-5653656
R-HSA-1632852
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-73857
R-HSA-5654736
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-9034015
R-HSA-186797
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-167044
R-HSA-373752
|
Immune System
Cell-Cell communication
Cell Cycle
Developmental Biology
Autophagy
Gene expression (Transcription)
Neuronal System
Signal Transduction
Vesicle-mediated transport
Hemostasis
|
R-HSA-1252013
(
R-HSA-1251985
)
R-HSA-1252013
Reaction Name: Translocation of ERBB4s80 to the nucleus
See in Reactome
R-HSA-177923
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-186819
(
R-HSA-186763
)
R-HSA-186819
Reaction Name: SH2 domain of Src binds to the active receptor
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-354066
(
R-HSA-354192
)
R-HSA-354066
Reaction Name: Translocation of PTK2 to Focal complexes
See in Reactome
R-HSA-354073
(
R-HSA-354192
)
R-HSA-354073
Reaction Name: Autophosphorylation of PTK2 at Y397
See in Reactome
R-HSA-354077
(
R-HSA-354192
)
R-HSA-354077
Reaction Name: Integrin alphaIIb beta3 activation
See in Reactome
R-HSA-354087
(
R-HSA-354192;
R-HSA-354194
)
R-HSA-354124
(
R-HSA-354192
)
R-HSA-354124
Reaction Name: Phosphorylation of pPTK2 by SRC
See in Reactome
R-HSA-354149
(
R-HSA-354192
)
R-HSA-354149
Reaction Name: Interaction of integrin alphaIIb beta3 with Fibrinogen
See in Reactome
R-HSA-354165
(
R-HSA-354192;
R-HSA-354194
)
R-HSA-354165
Reaction Name: Interaction of SOS with GRB2 bound to FADK1
See in Reactome
R-HSA-372693
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372693
Reaction Name: Phosphorylation of BCAR1 by SRC-PTK2 complex
See in Reactome
R-HSA-372697
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372705
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372705
Reaction Name: Recruitment of BCAR1 to PTK2 complex
See in Reactome
R-HSA-373716
(
R-HSA-418885
)
R-HSA-374701
(
R-HSA-418885
)
R-HSA-377640
(
R-HSA-354192
)
R-HSA-377641
(
R-HSA-354192
)
R-HSA-377641
Reaction Name: Clustering of Integrin alphaIIb beta3 complexes
See in Reactome
R-HSA-377643
(
R-HSA-354192
)
R-HSA-377643
Reaction Name: Dephosphorylation of inactive SRC by PTPB1
See in Reactome
R-HSA-377644
(
R-HSA-354192
)
R-HSA-380780
(
R-HSA-186763
)
R-HSA-418850
(
R-HSA-418885
)
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418858
(
R-HSA-418885
)
R-HSA-418858
Reaction Name: RhoGTPase GEF's recruited to DCC
See in Reactome
R-HSA-418859
(
R-HSA-418886
)
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-418868
(
R-HSA-418885
)
R-HSA-418868
Reaction Name: Recruitment of Src and Fyn to DCC:FADK1
See in Reactome
R-HSA-418874
(
R-HSA-418885
)
R-HSA-418874
Reaction Name: Recruitment and activation of N-WASP by Cdc42
See in Reactome
R-HSA-429415
(
R-HSA-354192
)
R-HSA-429415
Reaction Name: SYK binds to integrin alphaIIb beta3
See in Reactome
R-HSA-429441
(
R-HSA-354192
)
R-HSA-432096
(
R-HSA-354192
)
R-HSA-432096
Reaction Name: Activated integrin alphaIIb beta3 binds SHC1
See in Reactome
R-HSA-443905
(
R-HSA-354192
)
R-HSA-443905
Reaction Name: SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow
See in Reactome
R-HSA-443910
(
R-HSA-354192
)
R-HSA-443910
Reaction Name: SHC1 dissociates from integrin alphaIIb beta3
See in Reactome
R-HSA-5672969
(
R-HSA-5673000
)
R-HSA-5672972
(
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-8874080
(
R-HSA-8874081
)
R-HSA-8874082
(
R-HSA-8874081
)
R-HSA-8874083
(
R-HSA-8874081
)
R-HSA-8937682
(
R-HSA-8934593
)
R-HSA-8937728
(
R-HSA-8934593
)
R-HSA-8937792
(
R-HSA-8941858
)
R-HSA-8937807
(
R-HSA-8941858
)
R-HSA-8937814
(
R-HSA-8941858
)
R-HSA-8937814
Reaction Name: RUNX3 translocates to the nucleus
See in Reactome
R-HSA-8937820
(
R-HSA-8940973
)
R-HSA-8937844
(
R-HSA-8940973
)
R-HSA-8964242
(
R-HSA-418594
)
R-HSA-8964242
Reaction Name: G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC
See in Reactome
R-HSA-8964252
(
R-HSA-418555
)
R-HSA-8964252
Reaction Name: G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC
See in Reactome
R-HSA-8964278
(
R-HSA-418555
)
R-HSA-8964278
Reaction Name: G protein alpha (s):GTP binds SRC
See in Reactome
R-HSA-8964287
(
R-HSA-418555
)
R-HSA-8964287
Reaction Name: G alpha (s):GTP:SRC dissociates
See in Reactome
R-HSA-8964311
(
R-HSA-418594
)
R-HSA-8964329
(
R-HSA-418594
)
R-HSA-8964329
Reaction Name: G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC
See in Reactome
R-HSA-9011241
(
R-HSA-428542
)
R-HSA-9011241
Reaction Name: SRC phosphorylates ROBO3.1 in response to NTN1
See in Reactome
R-HSA-9021596
(
R-HSA-9009391
)
R-HSA-9021596
Reaction Name: Membrane estrogen receptors bind SRC
See in Reactome
R-HSA-9021609
(
R-HSA-9009391
)
R-HSA-9021609
Reaction Name: ESR-associated SRC autophosphorylates
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9037040
(
R-HSA-9032500
)
R-HSA-9603419
(
R-HSA-9603381
)
R-HSA-9603420
(
R-HSA-9603381
)
R-HSA-9603420
Reaction Name: Activated NTRK3 promotes SRC autophosphorylation
See in Reactome
R-HSA-9603437
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9612085
(
R-HSA-9620244
)
R-HSA-9612085
Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs
See in Reactome
R-HSA-9612219
(
R-HSA-1253288
)
R-HSA-9624014
(
R-HSA-418555
)
R-HSA-9624014
Reaction Name: SHC1 is phosphorylated downstream of estrogen stimulation of GPER1
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9657599
(
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9726848
(
R-HSA-9013420
)
|
MONDO:0009759 |
BUB1B |
O60566 |
2.7.11.1
|
R-HSA-5663220
R-HSA-2500257
R-HSA-2500257
Reactome Name: Resolution of Sister Chromatid Cohesion
See in Reactome
R-HSA-176409
R-HSA-176409
Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-9648025
R-HSA-9648025
Reactome Name: EML4 and NUDC in mitotic spindle formation
See in Reactome
R-HSA-141430
R-HSA-141430
Reactome Name: Inactivation of APC/C via direct inhibition of the APC/C complex
See in Reactome
R-HSA-179409
R-HSA-179409
Reactome Name: APC-Cdc20 mediated degradation of Nek2A
See in Reactome
R-HSA-174184
R-HSA-174184
Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A
See in Reactome
R-HSA-141444
R-HSA-141444
Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
See in Reactome
R-HSA-68877
|
R-HSA-174143
R-HSA-174143
Reactome Name: APC/C-mediated degradation of cell cycle proteins
See in Reactome
R-HSA-195258
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-176408
R-HSA-176408
Reactome Name: Regulation of APC/C activators between G1/S and early anaphase
See in Reactome
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-176814
R-HSA-176814
Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-141424
R-HSA-141424
Reactome Name: Amplification of signal from the kinetochores
See in Reactome
R-HSA-194315
R-HSA-453276
R-HSA-453276
Reactome Name: Regulation of mitotic cell cycle
See in Reactome
R-HSA-69620
R-HSA-68886
R-HSA-69278
R-HSA-68882
R-HSA-179419
R-HSA-179419
Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
See in Reactome
R-HSA-1640170
R-HSA-141405
R-HSA-141405
Reactome Name: Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
See in Reactome
R-HSA-69618
R-HSA-162582
|
Cell Cycle
Signal Transduction
|
R-HSA-141409
(
R-HSA-141444
)
R-HSA-141422
(
R-HSA-141444
)
R-HSA-141422
Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1
See in Reactome
R-HSA-141423
(
R-HSA-141430
)
R-HSA-141423
Reaction Name: Binding of the MCC complex to the APC/C complex
See in Reactome
R-HSA-141431
(
R-HSA-141444
)
R-HSA-141431
Reaction Name: MAD2 associates with the Mad1 kinetochore complex
See in Reactome
R-HSA-141437
(
R-HSA-141430
)
R-HSA-141439
(
R-HSA-141444
)
R-HSA-141439
Reaction Name: Release of activated MAD2 from kinetochores
See in Reactome
R-HSA-1638803
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638803
Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres
See in Reactome
R-HSA-1638821
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638821
Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin
See in Reactome
R-HSA-174104
(
R-HSA-174184;
R-HSA-176409
)
R-HSA-174104
Reaction Name: Ubiquitination of Cyclin A by APC/C:Cdc20 complex
See in Reactome
R-HSA-174171
(
R-HSA-174184;
R-HSA-176409
)
R-HSA-174171
Reaction Name: Association of Cyclin A with the APC/C
See in Reactome
R-HSA-174238
(
R-HSA-176409
)
R-HSA-174238
Reaction Name: Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1
See in Reactome
R-HSA-174255
(
R-HSA-174184;
R-HSA-176409
)
R-HSA-174255
Reaction Name: Degradation multiubiquitinated Cyclin A
See in Reactome
R-HSA-179410
(
R-HSA-176409;
R-HSA-179409
)
R-HSA-179410
Reaction Name: Association of Nek2A with MCC:APC/C
See in Reactome
R-HSA-179417
(
R-HSA-176409;
R-HSA-179409
)
R-HSA-179421
(
R-HSA-176409;
R-HSA-179409
)
R-HSA-179421
Reaction Name: Degradation of multiubiquitinated Nek2A
See in Reactome
R-HSA-2467809
(
R-HSA-2467813
)
R-HSA-2467809
Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin
See in Reactome
R-HSA-2467811
(
R-HSA-2467813
)
R-HSA-2467811
Reaction Name: Separation of sister chromatids
See in Reactome
R-HSA-2468287
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-2468287
Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres
See in Reactome
R-HSA-2484822
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-375302
(
R-HSA-68877
)
R-HSA-375302
Reaction Name: Kinetochore capture of astral microtubules
See in Reactome
R-HSA-5666129
(
R-HSA-5663220
)
R-HSA-5666129
Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores
See in Reactome
R-HSA-5666160
(
R-HSA-5663220
)
R-HSA-5666160
Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores
See in Reactome
R-HSA-5666169
(
R-HSA-5663220
)
R-HSA-5666169
Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
See in Reactome
R-HSA-9648114
(
R-HSA-68877;
R-HSA-9648025
)
R-HSA-9648114
Reaction Name: EML4 recruits NUDC to mitotic spindle
See in Reactome
|
MONDO:0010150 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0010150 |
RAC1 |
P63000 |
3.6.5.2
|
R-HSA-376172
R-HSA-445144
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-9619229
R-HSA-9619229
Reactome Name: Activation of RAC1 downstream of NMDARs
See in Reactome
R-HSA-428540
R-HSA-428543
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-399954
R-HSA-399954
Reactome Name: Sema3A PAK dependent Axon repulsion
See in Reactome
R-HSA-9032845
R-HSA-9032845
Reactome Name: Activated NTRK2 signals through CDK5
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-6798695
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-193648
R-HSA-193648
Reactome Name: NRAGE signals death through JNK
See in Reactome
R-HSA-5625900
R-HSA-5625740
R-HSA-9032759
R-HSA-1257604
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-389359
R-HSA-5627123
R-HSA-399955
R-HSA-399955
Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
See in Reactome
R-HSA-5626467
R-HSA-4420097
R-HSA-5663220
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5687128
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1433557
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-2424491
R-HSA-9013149
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-8875555
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-3928664
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-8848021
R-HSA-1280218
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9675108
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-112316
R-HSA-8875878
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-373760
R-HSA-9032500
R-HSA-9032500
Reactome Name: Activated NTRK2 signals through FYN
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-168249
R-HSA-195258
R-HSA-199991
R-HSA-73887
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-2682334
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-5653656
R-HSA-6806834
R-HSA-195721
R-HSA-2172127
R-HSA-204998
R-HSA-204998
Reactome Name: Cell death signalling via NRAGE, NRIF and NADE
See in Reactome
R-HSA-373755
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Developmental Biology
Neuronal System
Vesicle-mediated transport
Hemostasis
Signal Transduction
|
R-HSA-1011598
(
R-HSA-983231
)
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1433415
(
R-HSA-1433557
)
R-HSA-2029451
(
R-HSA-2029482
)
R-HSA-2029454
(
R-HSA-2029482
)
R-HSA-2029456
(
R-HSA-2029482;
R-HSA-5627123
)
R-HSA-2029465
(
R-HSA-2029482;
R-HSA-4420097;
R-HSA-5663213
)
R-HSA-2029465
Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)
See in Reactome
R-HSA-2029466
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029466
Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin
See in Reactome
R-HSA-2029467
(
R-HSA-2029482
)
R-HSA-2029467
Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO
See in Reactome
R-HSA-2029469
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029469
Reaction Name: p-ERK phosphorylates WAVEs and ABI
See in Reactome
R-HSA-205039
(
R-HSA-193648
)
R-HSA-205039
Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
See in Reactome
R-HSA-205136
(
R-HSA-193648
)
R-HSA-205136
Reaction Name: GTP-bound RAC contributes to JNK activation
See in Reactome
R-HSA-2130194
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2197690
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2316352
(
R-HSA-1445148
)
R-HSA-2316352
Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424476
(
R-HSA-2424491
)
R-HSA-2730840
(
R-HSA-2871796
)
R-HSA-2730856
(
R-HSA-2871796
)
R-HSA-2730889
(
R-HSA-2871796
)
R-HSA-2730889
Reaction Name: Recruitment of PAK to the membrane by binding active RAC1
See in Reactome
R-HSA-376123
(
R-HSA-376172
)
R-HSA-376123
Reaction Name: DSCAM associates with Rac1-GTP:pPAK1
See in Reactome
R-HSA-3858475
(
R-HSA-4086400
)
R-HSA-389348
(
R-HSA-389359
)
R-HSA-389788
(
R-HSA-389359;
R-HSA-5687128
)
R-HSA-389788
Reaction Name: Activation of PAKs by RAC1 and CDC42
See in Reactome
R-HSA-3928612
(
R-HSA-3928662
)
R-HSA-3928612
Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928619
(
R-HSA-3928662
)
R-HSA-3928620
(
R-HSA-3928662
)
R-HSA-3928625
(
R-HSA-3928664
)
R-HSA-3928628
(
R-HSA-3928665
)
R-HSA-3928628
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928633
(
R-HSA-3928664
)
R-HSA-3928633
Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it
See in Reactome
R-HSA-3928640
(
R-HSA-3928664
)
R-HSA-3928641
(
R-HSA-3928664
)
R-HSA-3928642
(
R-HSA-3928665
)
R-HSA-3928642
Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-399928
(
R-HSA-399955
)
R-HSA-399928
Reaction Name: Recruitment of Rnd1 to Plexin A
See in Reactome
R-HSA-399930
(
R-HSA-399954
)
R-HSA-399935
(
R-HSA-399955
)
R-HSA-399935
Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity
See in Reactome
R-HSA-399938
(
R-HSA-399955
)
R-HSA-399939
(
R-HSA-399954
)
R-HSA-399941
(
R-HSA-399955
)
R-HSA-399952
(
R-HSA-399954
)
R-HSA-399952
Reaction Name: Phosphorylation of LIMK-1 by PAK
See in Reactome
R-HSA-400682
(
R-HSA-416550
)
R-HSA-400682
Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D
See in Reactome
R-HSA-4093336
(
R-HSA-3928662
)
R-HSA-4093336
Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-428522
(
R-HSA-428543
)
R-HSA-428535
(
R-HSA-428540
)
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442592
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-442592
Reaction Name: WASPs or WAVEs activate the ARP2/3 complex
See in Reactome
R-HSA-445064
(
R-HSA-445144
)
R-HSA-445072
(
R-HSA-445144
)
R-HSA-445072
Reaction Name: Interaction of PAK1 with Rac1-GTP
See in Reactome
R-HSA-451347
(
R-HSA-376172
)
R-HSA-451366
(
R-HSA-376172
)
R-HSA-5218827
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218827
Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1
See in Reactome
R-HSA-5218839
(
R-HSA-4420097
)
R-HSA-5218839
Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1
See in Reactome
R-HSA-5218841
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218841
Reaction Name: NADPH oxidase 2 generates superoxide from oxygen
See in Reactome
R-HSA-5218850
(
R-HSA-4420097
)
R-HSA-5218850
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-5357445
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357472
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357483
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5626469
(
R-HSA-5626467
)
R-HSA-5626469
Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs
See in Reactome
R-HSA-5626507
(
R-HSA-5626467
)
R-HSA-5626507
Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin
See in Reactome
R-HSA-5626549
(
R-HSA-5626467
)
R-HSA-5627775
(
R-HSA-5627123;
R-HSA-5687128
)
R-HSA-5627775
Reaction Name: Autophosphorylation of PAK1,2,3
See in Reactome
R-HSA-5663232
(
R-HSA-5663220
)
R-HSA-5665659
(
R-HSA-5663220
)
R-HSA-5665659
Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin
See in Reactome
R-HSA-5665802
(
R-HSA-5663220
)
R-HSA-5665802
Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin
See in Reactome
R-HSA-5665809
(
R-HSA-5663220
)
R-HSA-5665809
Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments
See in Reactome
R-HSA-5668714
(
R-HSA-5668599
)
R-HSA-5668718
(
R-HSA-5668599
)
R-HSA-5668718
Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen
See in Reactome
R-HSA-5668731
(
R-HSA-5668599
)
R-HSA-5668731
Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen
See in Reactome
R-HSA-5668735
(
R-HSA-5668599
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5672304
(
R-HSA-5626467
)
R-HSA-5672304
Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1
See in Reactome
R-HSA-5672329
(
R-HSA-5626467
)
R-HSA-5672329
Reaction Name: IQGAP1 binds CLIP1 and microtubules
See in Reactome
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8848618
(
R-HSA-8849471
)
R-HSA-8848618
Reaction Name: Activation of RAC1 by the PXN:CRK complex
See in Reactome
R-HSA-8875591
(
R-HSA-8875555
)
R-HSA-8951586
(
R-HSA-4420097
)
R-HSA-8951586
Reaction Name: p-VAV family:PIP3 binds RAC1:GDP
See in Reactome
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981926
(
R-HSA-5627123
)
R-HSA-8981931
(
R-HSA-5627123
)
R-HSA-9013143
(
R-HSA-9013149
)
R-HSA-9013144
(
R-HSA-9013149
)
R-HSA-9013144
Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9013147
(
R-HSA-9013149
)
R-HSA-9013147
Reaction Name: RAC1 GDIs block activation of RAC1
See in Reactome
R-HSA-9032798
(
R-HSA-9032759
)
R-HSA-9033292
(
R-HSA-9032845
)
R-HSA-9033292
Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1
See in Reactome
R-HSA-9619803
(
R-HSA-9619229
)
R-HSA-9691168
(
R-HSA-9013149
)
R-HSA-9691168
Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane
See in Reactome
R-HSA-9691174
(
R-HSA-9013149
)
R-HSA-9691174
Reaction Name: RAC1 binds effectors at the ER membrane
See in Reactome
|
MONDO:0011953 |
RANBP2 |
P49792 |
2.3.2.-
|
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-170822
R-HSA-170822
Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein
See in Reactome
R-HSA-1169408
R-HSA-4615885
R-HSA-4615885
Reactome Name: SUMOylation of DNA replication proteins
See in Reactome
R-HSA-2500257
R-HSA-2500257
Reactome Name: Resolution of Sister Chromatid Cohesion
See in Reactome
R-HSA-159230
R-HSA-159230
Reactome Name: Transport of the SLBP Dependant Mature mRNA
See in Reactome
R-HSA-159231
R-HSA-159231
Reactome Name: Transport of Mature mRNA Derived from an Intronless Transcript
See in Reactome
R-HSA-9648025
R-HSA-9648025
Reactome Name: EML4 and NUDC in mitotic spindle formation
See in Reactome
R-HSA-3232142
R-HSA-3232142
Reactome Name: SUMOylation of ubiquitinylation proteins
See in Reactome
R-HSA-4085377
R-HSA-4085377
Reactome Name: SUMOylation of SUMOylation proteins
See in Reactome
R-HSA-159236
R-HSA-159236
Reactome Name: Transport of Mature mRNA derived from an Intron-Containing Transcript
See in Reactome
R-HSA-4551638
R-HSA-4551638
Reactome Name: SUMOylation of chromatin organization proteins
See in Reactome
R-HSA-141444
R-HSA-141444
Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
See in Reactome
R-HSA-5663220
R-HSA-191859
R-HSA-159227
R-HSA-159227
Reactome Name: Transport of the SLBP independent Mature mRNA
See in Reactome
R-HSA-6784531
R-HSA-6784531
Reactome Name: tRNA processing in the nucleus
See in Reactome
R-HSA-4570464
R-HSA-4570464
Reactome Name: SUMOylation of RNA binding proteins
See in Reactome
R-HSA-3108214
R-HSA-3108214
Reactome Name: SUMOylation of DNA damage response and repair proteins
See in Reactome
R-HSA-5578749
R-HSA-5578749
Reactome Name: Transcriptional regulation by small RNAs
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
R-HSA-68877
R-HSA-3301854
R-HSA-3301854
Reactome Name: Nuclear Pore Complex (NPC) Disassembly
See in Reactome
|
R-HSA-70326
R-HSA-168256
R-HSA-194315
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-1430728
R-HSA-72203
R-HSA-72203
Reactome Name: Processing of Capped Intron-Containing Pre-mRNA
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1640170
R-HSA-72306
R-HSA-194441
R-HSA-71387
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-74160
R-HSA-159234
R-HSA-159234
Reactome Name: Transport of Mature mRNAs Derived from Intronless Transcripts
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-69278
R-HSA-2990846
R-HSA-913531
R-HSA-211000
R-HSA-8953897
R-HSA-141424
R-HSA-141424
Reactome Name: Amplification of signal from the kinetochores
See in Reactome
R-HSA-8953854
R-HSA-392499
R-HSA-68886
R-HSA-70171
R-HSA-68882
R-HSA-1169410
R-HSA-1169410
Reactome Name: Antiviral mechanism by IFN-stimulated genes
See in Reactome
R-HSA-195258
R-HSA-3108232
R-HSA-3108232
Reactome Name: SUMO E3 ligases SUMOylate target proteins
See in Reactome
R-HSA-2980766
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-72202
R-HSA-72202
Reactome Name: Transport of Mature Transcript to Cytoplasm
See in Reactome
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-69618
R-HSA-162582
R-HSA-68875
|
Immune System
Metabolism
Cell Cycle
Gene expression (Transcription)
Cellular responses to stimuli
Metabolism of RNA
Metabolism of proteins
Signal Transduction
|
R-HSA-111439
(
R-HSA-159227
)
R-HSA-111439
Reaction Name: Docking of Mature Histone mRNA complex:TAP at the NPC
See in Reactome
R-HSA-1176059
(
R-HSA-1169408
)
R-HSA-1176059
Reaction Name: Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus
See in Reactome
R-HSA-141409
(
R-HSA-141444
)
R-HSA-141422
(
R-HSA-141444
)
R-HSA-141422
Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1
See in Reactome
R-HSA-141431
(
R-HSA-141444
)
R-HSA-141431
Reaction Name: MAD2 associates with the Mad1 kinetochore complex
See in Reactome
R-HSA-141439
(
R-HSA-141444
)
R-HSA-141439
Reaction Name: Release of activated MAD2 from kinetochores
See in Reactome
R-HSA-158441
(
R-HSA-159231
)
R-HSA-158441
Reaction Name: Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC
See in Reactome
R-HSA-158447
(
R-HSA-159231
)
R-HSA-158447
Reaction Name: Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC
See in Reactome
R-HSA-158481
(
R-HSA-159227
)
R-HSA-158481
Reaction Name: Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC
See in Reactome
R-HSA-158484
(
R-HSA-159227
)
R-HSA-158484
Reaction Name: Release of the SLBP independent Histone mRNA from the NPC
See in Reactome
R-HSA-159046
(
R-HSA-159230
)
R-HSA-159046
Reaction Name: Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC
See in Reactome
R-HSA-159050
(
R-HSA-159230
)
R-HSA-159050
Reaction Name: Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex
See in Reactome
R-HSA-1638803
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638803
Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres
See in Reactome
R-HSA-1638821
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638821
Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin
See in Reactome
R-HSA-170796
(
R-HSA-170822
)
R-HSA-170796
Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm
See in Reactome
R-HSA-191825
(
R-HSA-191859
)
R-HSA-191825
Reaction Name: Nuclear export of snRNA transcripts
See in Reactome
R-HSA-191830
(
R-HSA-191859
)
R-HSA-191830
Reaction Name: snRNP nuclear import and release
See in Reactome
R-HSA-2467809
(
R-HSA-2467813
)
R-HSA-2467809
Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin
See in Reactome
R-HSA-2467811
(
R-HSA-2467813
)
R-HSA-2467811
Reaction Name: Separation of sister chromatids
See in Reactome
R-HSA-2468287
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-2468287
Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres
See in Reactome
R-HSA-2484822
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-2990880
(
R-HSA-3301854
)
R-HSA-2990880
Reaction Name: NEK6/NEK7 phosphorylates NUP98
See in Reactome
R-HSA-2990882
(
R-HSA-3301854
)
R-HSA-3000348
(
R-HSA-3108214
)
R-HSA-3000348
Reaction Name: RANBP2 SUMOylates SP100 with SUMO2
See in Reactome
R-HSA-3000399
(
R-HSA-3108214
)
R-HSA-3000399
Reaction Name: RANBP2 SUMOylates SP100 with SUMO1
See in Reactome
R-HSA-3000411
(
R-HSA-3108214
)
R-HSA-3000411
Reaction Name: RANBP2 SUMOylates PML with SUMO2
See in Reactome
R-HSA-375302
(
R-HSA-68877
)
R-HSA-375302
Reaction Name: Kinetochore capture of astral microtubules
See in Reactome
R-HSA-4551649
(
R-HSA-4085377
)
R-HSA-4551649
Reaction Name: RANBP2 SUMOylates RANBP2 with SUMO1
See in Reactome
R-HSA-4551679
(
R-HSA-4085377
)
R-HSA-4551679
Reaction Name: RANBP2 SUMOylates RANBP2 with SUMO2
See in Reactome
R-HSA-4570493
(
R-HSA-4570464
)
R-HSA-4570493
Reaction Name: RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1
See in Reactome
R-HSA-4615872
(
R-HSA-4551638
)
R-HSA-4615872
Reaction Name: RANBP2 SUMOylates HDAC4 with SUMO1
See in Reactome
R-HSA-4615987
(
R-HSA-4551638
)
R-HSA-4615987
Reaction Name: RANBP2 SUMOylates HDAC4 with SUMO2,3
See in Reactome
R-HSA-4655355
(
R-HSA-4615885
)
R-HSA-4655355
Reaction Name: RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)
See in Reactome
R-HSA-5228508
(
R-HSA-3108214
)
R-HSA-5228508
Reaction Name: RANBP2 SUMOylates PML with SUMO1
See in Reactome
R-HSA-5228523
(
R-HSA-3232142
)
R-HSA-5228523
Reaction Name: RANBP2 SUMOylates MDM2 with SUMO1
See in Reactome
R-HSA-5228525
(
R-HSA-4615885
)
R-HSA-5228525
Reaction Name: RANBP2 SUMOylates TOP2A with SUMO1
See in Reactome
R-HSA-5252041
(
R-HSA-3371453
)
R-HSA-5252041
Reaction Name: NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm
See in Reactome
R-HSA-5578744
(
R-HSA-5578749
)
R-HSA-5578744
Reaction Name: Importin-8 imports AGO2:miRNA into the nucleus
See in Reactome
R-HSA-5666129
(
R-HSA-5663220
)
R-HSA-5666129
Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores
See in Reactome
R-HSA-5666160
(
R-HSA-5663220
)
R-HSA-5666160
Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores
See in Reactome
R-HSA-5666169
(
R-HSA-5663220
)
R-HSA-5666169
Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
See in Reactome
R-HSA-6783483
(
R-HSA-6784531
)
R-HSA-6783483
Reaction Name: tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol
See in Reactome
R-HSA-75096
(
R-HSA-159236
)
R-HSA-75096
Reaction Name: Docking of the TAP:EJC Complex with the NPC
See in Reactome
R-HSA-75097
(
R-HSA-159236
)
R-HSA-75097
Reaction Name: Transport of the export-competent mRNP complex through the NPC
See in Reactome
R-HSA-75098
(
R-HSA-159236
)
R-HSA-75098
Reaction Name: mRNP complex dissociates from cytosolic face of NPC
See in Reactome
R-HSA-77587
(
R-HSA-159230
)
R-HSA-77587
Reaction Name: Docking of Mature Replication Dependent Histone mRNA with the NPC
See in Reactome
R-HSA-77594
(
R-HSA-159231
)
R-HSA-77594
Reaction Name: Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC
See in Reactome
R-HSA-9648114
(
R-HSA-68877;
R-HSA-9648025
)
R-HSA-9648114
Reaction Name: EML4 recruits NUDC to mitotic spindle
See in Reactome
|
MONDO:0014757 |
CDC42 |
P60953 |
3.6.5.2
|
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-428543
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-5627123
R-HSA-8950505
R-HSA-8950505
Reactome Name: Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
See in Reactome
R-HSA-389359
R-HSA-525793
R-HSA-5626467
R-HSA-4420097
R-HSA-5663220
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5687128
R-HSA-9013423
R-HSA-9013149
R-HSA-9013148
R-HSA-182971
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-9013424
R-HSA-9013420
R-HSA-5625970
R-HSA-9013408
R-HSA-9013409
R-HSA-9013406
R-HSA-9013404
R-HSA-8964616
R-HSA-8964616
Reactome Name: G beta:gamma signalling through CDC42
See in Reactome
|
R-HSA-376176
R-HSA-9012999
R-HSA-449147
R-HSA-168256
R-HSA-194315
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-1280218
R-HSA-1266738
R-HSA-2682334
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-389356
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-388396
R-HSA-168249
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9020591
R-HSA-177929
R-HSA-195258
R-HSA-372790
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-194138
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Developmental Biology
Hemostasis
Signal Transduction
|
R-HSA-1011598
(
R-HSA-983231
)
R-HSA-183002
(
R-HSA-182971
)
R-HSA-183002
Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85
See in Reactome
R-HSA-183084
(
R-HSA-182971
)
R-HSA-183084
Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix
See in Reactome
R-HSA-183094
(
R-HSA-182971
)
R-HSA-2029445
(
R-HSA-2029482
)
R-HSA-2029445
Reaction Name: An unknown GEF exchanges GTP for GDP on CDC42:GDP
See in Reactome
R-HSA-2029454
(
R-HSA-2029482
)
R-HSA-2029456
(
R-HSA-2029482;
R-HSA-5627123
)
R-HSA-2029466
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029466
Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin
See in Reactome
R-HSA-2197690
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2197691
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2197691
Reaction Name: WIP binds WASP,N-WASP, activating them
See in Reactome
R-HSA-2197698
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-376117
(
R-HSA-525793
)
R-HSA-376119
(
R-HSA-525793
)
R-HSA-376119
Reaction Name: Interaction of Bnip-2 with Cdc42
See in Reactome
R-HSA-389350
(
R-HSA-389359
)
R-HSA-389788
(
R-HSA-389359;
R-HSA-5687128
)
R-HSA-389788
Reaction Name: Activation of PAKs by RAC1 and CDC42
See in Reactome
R-HSA-3928595
(
R-HSA-3928662
)
R-HSA-3928595
Reaction Name: N-WASP binds ARP2/3 and G-actin
See in Reactome
R-HSA-3928601
(
R-HSA-3928662
)
R-HSA-3928601
Reaction Name: CDC42 and PIP2 bind WASL, activating it
See in Reactome
R-HSA-3928632
(
R-HSA-3928662
)
R-HSA-3928632
Reaction Name: ITSN1 exchanges GTP for GDP on CDC42, activating it
See in Reactome
R-HSA-418850
(
R-HSA-418885
)
R-HSA-418874
(
R-HSA-418885
)
R-HSA-418874
Reaction Name: Recruitment and activation of N-WASP by Cdc42
See in Reactome
R-HSA-428533
(
R-HSA-428543
)
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442586
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-442586
Reaction Name: Activation of WASP and N-WASP by CDC42
See in Reactome
R-HSA-442592
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-442592
Reaction Name: WASPs or WAVEs activate the ARP2/3 complex
See in Reactome
R-HSA-448951
(
R-HSA-525793
)
R-HSA-448951
Reaction Name: Activation of p38 alpha/beta MAPK
See in Reactome
R-HSA-448957
(
R-HSA-525793
)
R-HSA-448957
Reaction Name: Interaction of p38 MAPK with JLP
See in Reactome
R-HSA-448958
(
R-HSA-525793
)
R-HSA-448958
Reaction Name: Nuclear translocation of p38 MAPK
See in Reactome
R-HSA-449200
(
R-HSA-525793
)
R-HSA-449200
Reaction Name: Interaction of ABL1 with CDO complex
See in Reactome
R-HSA-5218804
(
R-HSA-4420097
)
R-HSA-5218812
(
R-HSA-4420097
)
R-HSA-5218814
(
R-HSA-4420097
)
R-HSA-5218829
(
R-HSA-4420097
)
R-HSA-5218829
Reaction Name: VEGF induces CDC42 activation by unknown mechanism
See in Reactome
R-HSA-5218832
(
R-HSA-4420097
)
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5626469
(
R-HSA-5626467
)
R-HSA-5626469
Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs
See in Reactome
R-HSA-5626507
(
R-HSA-5626467
)
R-HSA-5626507
Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin
See in Reactome
R-HSA-5626549
(
R-HSA-5626467
)
R-HSA-5627775
(
R-HSA-5627123;
R-HSA-5687128
)
R-HSA-5627775
Reaction Name: Autophosphorylation of PAK1,2,3
See in Reactome
R-HSA-5665686
(
R-HSA-5663220
)
R-HSA-5665727
(
R-HSA-5663220
)
R-HSA-5665751
(
R-HSA-5663220
)
R-HSA-5665751
Reaction Name: CDC42:GTP:FMNL2 binds Profilin:G-actin
See in Reactome
R-HSA-5666129
(
R-HSA-5663220
)
R-HSA-5666129
Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores
See in Reactome
R-HSA-5666160
(
R-HSA-5663220
)
R-HSA-5666160
Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores
See in Reactome
R-HSA-5666169
(
R-HSA-5663220
)
R-HSA-5666169
Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
See in Reactome
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5672304
(
R-HSA-5626467
)
R-HSA-5672304
Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1
See in Reactome
R-HSA-5672329
(
R-HSA-5626467
)
R-HSA-5672329
Reaction Name: IQGAP1 binds CLIP1 and microtubules
See in Reactome
R-HSA-8950637
(
R-HSA-8950505
)
R-HSA-8950637
Reaction Name: Expression of cell division cycle 42
See in Reactome
R-HSA-8951490
(
R-HSA-182971
)
R-HSA-8951490
Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85
See in Reactome
R-HSA-8964599
(
R-HSA-8964616
)
R-HSA-8964599
Reaction Name: Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex
See in Reactome
R-HSA-8964604
(
R-HSA-8964616
)
R-HSA-8964604
Reaction Name: CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated
See in Reactome
R-HSA-8964614
(
R-HSA-8964616
)
R-HSA-8964614
Reaction Name: PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated
See in Reactome
R-HSA-8964634
(
R-HSA-8964616
)
R-HSA-8964634
Reaction Name: CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex
See in Reactome
R-HSA-8981926
(
R-HSA-5627123
)
R-HSA-8981931
(
R-HSA-5627123
)
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9013157
(
R-HSA-9013148
)
R-HSA-9013157
Reaction Name: CDC42 binds effectors at the plasma membrane
See in Reactome
R-HSA-9013158
(
R-HSA-9013148
)
R-HSA-9013158
Reaction Name: CDC42 GDIs block activation of CDC42
See in Reactome
R-HSA-9013159
(
R-HSA-9013148
)
R-HSA-9013161
(
R-HSA-9013148
)
R-HSA-9013161
Reaction Name: CDC42 GAPs stimulate CDC42 GTPase activity
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014449
(
R-HSA-9013408
)
R-HSA-9014449
Reaction Name: RHOG binds effectors at the plasma membrane
See in Reactome
R-HSA-9017507
(
R-HSA-9013409
)
R-HSA-9017507
Reaction Name: RHOJ binds effectors at the plasma membrane
See in Reactome
R-HSA-9018746
(
R-HSA-9013406
)
R-HSA-9018746
Reaction Name: RHOQ binds effectors at the plasma membrane
See in Reactome
R-HSA-9018766
(
R-HSA-9013420
)
R-HSA-9018766
Reaction Name: RHOU binds effectors at the plasma membrane
See in Reactome
R-HSA-9018794
(
R-HSA-9013424
)
R-HSA-9018794
Reaction Name: RHOV binds effectors at the plasma membrane
See in Reactome
R-HSA-9018808
(
R-HSA-9013423
)
R-HSA-9018808
Reaction Name: RAC3 binds effectors at the plasma membrane
See in Reactome
R-HSA-9692800
(
R-HSA-9013148
)
R-HSA-9692800
Reaction Name: CDC42 translocates to the endoplasmic reticulum membrane
See in Reactome
R-HSA-9692809
(
R-HSA-9013148
)
R-HSA-9692809
Reaction Name: CDC42 binds effectors at the ER membrane
See in Reactome
|
MONDO:0014837 |
SRC |
P12931 |
2.7.10.2
|
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-171007
R-HSA-428542
R-HSA-428542
Reactome Name: Regulation of commissural axon pathfinding by SLIT and ROBO
See in Reactome
R-HSA-418594
R-HSA-8940973
R-HSA-8940973
Reactome Name: RUNX2 regulates osteoblast differentiation
See in Reactome
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-437239
R-HSA-418592
R-HSA-418592
Reactome Name: ADP signalling through P2Y purinoceptor 1
See in Reactome
R-HSA-430116
R-HSA-430116
Reactome Name: GP1b-IX-V activation signalling
See in Reactome
R-HSA-5663220
R-HSA-186763
R-HSA-180292
R-HSA-8941858
R-HSA-8941858
Reactome Name: Regulation of RUNX3 expression and activity
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-418555
R-HSA-5673000
R-HSA-9032500
R-HSA-9032500
Reactome Name: Activated NTRK2 signals through FYN
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-8934903
R-HSA-8853659
R-HSA-372708
R-HSA-372708
Reactome Name: p130Cas linkage to MAPK signaling for integrins
See in Reactome
R-HSA-389356
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-4420097
R-HSA-1433559
R-HSA-2029481
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-1433557
R-HSA-9620244
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-5607764
R-HSA-5674135
R-HSA-8874081
R-HSA-1253288
R-HSA-1253288
Reactome Name: Downregulation of ERBB4 signaling
See in Reactome
R-HSA-2682334
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-177929
R-HSA-1251985
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-354194
R-HSA-354194
Reactome Name: GRB2:SOS provides linkage to MAPK signaling for Integrins
See in Reactome
R-HSA-3928664
R-HSA-456926
R-HSA-456926
Reactome Name: Thrombin signalling through proteinase activated receptors (PARs)
See in Reactome
R-HSA-354192
R-HSA-201556
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-191650
R-HSA-191650
Reactome Name: Regulation of gap junction activity
See in Reactome
R-HSA-9013420
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-1227986
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-376176
R-HSA-9012999
R-HSA-8941326
R-HSA-8941326
Reactome Name: RUNX2 regulates bone development
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-195258
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-1640170
R-HSA-373760
R-HSA-5684996
R-HSA-1280218
R-HSA-1266738
R-HSA-5673001
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-9612973
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-5205647
R-HSA-388396
R-HSA-112316
R-HSA-162582
R-HSA-8875878
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-9675108
R-HSA-168249
R-HSA-9663891
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-392518
R-HSA-8939211
R-HSA-157858
R-HSA-157858
Reactome Name: Gap junction trafficking and regulation
See in Reactome
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-1236394
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-5653656
R-HSA-1632852
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-73857
R-HSA-5654736
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-9034015
R-HSA-186797
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-167044
R-HSA-373752
|
Immune System
Cell-Cell communication
Cell Cycle
Developmental Biology
Autophagy
Gene expression (Transcription)
Neuronal System
Signal Transduction
Vesicle-mediated transport
Hemostasis
|
R-HSA-1252013
(
R-HSA-1251985
)
R-HSA-1252013
Reaction Name: Translocation of ERBB4s80 to the nucleus
See in Reactome
R-HSA-177923
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-186819
(
R-HSA-186763
)
R-HSA-186819
Reaction Name: SH2 domain of Src binds to the active receptor
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-354066
(
R-HSA-354192
)
R-HSA-354066
Reaction Name: Translocation of PTK2 to Focal complexes
See in Reactome
R-HSA-354073
(
R-HSA-354192
)
R-HSA-354073
Reaction Name: Autophosphorylation of PTK2 at Y397
See in Reactome
R-HSA-354077
(
R-HSA-354192
)
R-HSA-354077
Reaction Name: Integrin alphaIIb beta3 activation
See in Reactome
R-HSA-354087
(
R-HSA-354192;
R-HSA-354194
)
R-HSA-354124
(
R-HSA-354192
)
R-HSA-354124
Reaction Name: Phosphorylation of pPTK2 by SRC
See in Reactome
R-HSA-354149
(
R-HSA-354192
)
R-HSA-354149
Reaction Name: Interaction of integrin alphaIIb beta3 with Fibrinogen
See in Reactome
R-HSA-354165
(
R-HSA-354192;
R-HSA-354194
)
R-HSA-354165
Reaction Name: Interaction of SOS with GRB2 bound to FADK1
See in Reactome
R-HSA-372693
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372693
Reaction Name: Phosphorylation of BCAR1 by SRC-PTK2 complex
See in Reactome
R-HSA-372697
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372705
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372705
Reaction Name: Recruitment of BCAR1 to PTK2 complex
See in Reactome
R-HSA-373716
(
R-HSA-418885
)
R-HSA-374701
(
R-HSA-418885
)
R-HSA-377640
(
R-HSA-354192
)
R-HSA-377641
(
R-HSA-354192
)
R-HSA-377641
Reaction Name: Clustering of Integrin alphaIIb beta3 complexes
See in Reactome
R-HSA-377643
(
R-HSA-354192
)
R-HSA-377643
Reaction Name: Dephosphorylation of inactive SRC by PTPB1
See in Reactome
R-HSA-377644
(
R-HSA-354192
)
R-HSA-380780
(
R-HSA-186763
)
R-HSA-418850
(
R-HSA-418885
)
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418858
(
R-HSA-418885
)
R-HSA-418858
Reaction Name: RhoGTPase GEF's recruited to DCC
See in Reactome
R-HSA-418859
(
R-HSA-418886
)
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-418868
(
R-HSA-418885
)
R-HSA-418868
Reaction Name: Recruitment of Src and Fyn to DCC:FADK1
See in Reactome
R-HSA-418874
(
R-HSA-418885
)
R-HSA-418874
Reaction Name: Recruitment and activation of N-WASP by Cdc42
See in Reactome
R-HSA-429415
(
R-HSA-354192
)
R-HSA-429415
Reaction Name: SYK binds to integrin alphaIIb beta3
See in Reactome
R-HSA-429441
(
R-HSA-354192
)
R-HSA-432096
(
R-HSA-354192
)
R-HSA-432096
Reaction Name: Activated integrin alphaIIb beta3 binds SHC1
See in Reactome
R-HSA-443905
(
R-HSA-354192
)
R-HSA-443905
Reaction Name: SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow
See in Reactome
R-HSA-443910
(
R-HSA-354192
)
R-HSA-443910
Reaction Name: SHC1 dissociates from integrin alphaIIb beta3
See in Reactome
R-HSA-5672969
(
R-HSA-5673000
)
R-HSA-5672972
(
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-8874080
(
R-HSA-8874081
)
R-HSA-8874082
(
R-HSA-8874081
)
R-HSA-8874083
(
R-HSA-8874081
)
R-HSA-8937682
(
R-HSA-8934593
)
R-HSA-8937728
(
R-HSA-8934593
)
R-HSA-8937792
(
R-HSA-8941858
)
R-HSA-8937807
(
R-HSA-8941858
)
R-HSA-8937814
(
R-HSA-8941858
)
R-HSA-8937814
Reaction Name: RUNX3 translocates to the nucleus
See in Reactome
R-HSA-8937820
(
R-HSA-8940973
)
R-HSA-8937844
(
R-HSA-8940973
)
R-HSA-8964242
(
R-HSA-418594
)
R-HSA-8964242
Reaction Name: G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC
See in Reactome
R-HSA-8964252
(
R-HSA-418555
)
R-HSA-8964252
Reaction Name: G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC
See in Reactome
R-HSA-8964278
(
R-HSA-418555
)
R-HSA-8964278
Reaction Name: G protein alpha (s):GTP binds SRC
See in Reactome
R-HSA-8964287
(
R-HSA-418555
)
R-HSA-8964287
Reaction Name: G alpha (s):GTP:SRC dissociates
See in Reactome
R-HSA-8964311
(
R-HSA-418594
)
R-HSA-8964329
(
R-HSA-418594
)
R-HSA-8964329
Reaction Name: G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC
See in Reactome
R-HSA-9011241
(
R-HSA-428542
)
R-HSA-9011241
Reaction Name: SRC phosphorylates ROBO3.1 in response to NTN1
See in Reactome
R-HSA-9021596
(
R-HSA-9009391
)
R-HSA-9021596
Reaction Name: Membrane estrogen receptors bind SRC
See in Reactome
R-HSA-9021609
(
R-HSA-9009391
)
R-HSA-9021609
Reaction Name: ESR-associated SRC autophosphorylates
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9037040
(
R-HSA-9032500
)
R-HSA-9603419
(
R-HSA-9603381
)
R-HSA-9603420
(
R-HSA-9603381
)
R-HSA-9603420
Reaction Name: Activated NTRK3 promotes SRC autophosphorylation
See in Reactome
R-HSA-9603437
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9612085
(
R-HSA-9620244
)
R-HSA-9612085
Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs
See in Reactome
R-HSA-9612219
(
R-HSA-1253288
)
R-HSA-9624014
(
R-HSA-418555
)
R-HSA-9624014
Reaction Name: SHC1 is phosphorylated downstream of estrogen stimulation of GPER1
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9657599
(
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9726848
(
R-HSA-9013420
)
|
MONDO:0015802 |
TAOK1 |
Q7L7X3 |
2.7.11.1
|
R-HSA-5663220
R-HSA-2500257
R-HSA-2500257
Reactome Name: Resolution of Sister Chromatid Cohesion
See in Reactome
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-9648025
R-HSA-9648025
Reactome Name: EML4 and NUDC in mitotic spindle formation
See in Reactome
R-HSA-141444
R-HSA-141444
Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
See in Reactome
R-HSA-68877
|
R-HSA-195258
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-141424
R-HSA-141424
Reactome Name: Amplification of signal from the kinetochores
See in Reactome
R-HSA-194315
R-HSA-69620
R-HSA-68886
R-HSA-69278
R-HSA-68882
R-HSA-1640170
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-69618
R-HSA-162582
|
Cell Cycle
Signal Transduction
|
R-HSA-141409
(
R-HSA-141444
)
R-HSA-141422
(
R-HSA-141444
)
R-HSA-141422
Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1
See in Reactome
R-HSA-141431
(
R-HSA-141444
)
R-HSA-141431
Reaction Name: MAD2 associates with the Mad1 kinetochore complex
See in Reactome
R-HSA-141439
(
R-HSA-141444
)
R-HSA-141439
Reaction Name: Release of activated MAD2 from kinetochores
See in Reactome
R-HSA-1638803
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638803
Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres
See in Reactome
R-HSA-1638821
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638821
Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin
See in Reactome
R-HSA-2467809
(
R-HSA-2467813
)
R-HSA-2467809
Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin
See in Reactome
R-HSA-2467811
(
R-HSA-2467813
)
R-HSA-2467811
Reaction Name: Separation of sister chromatids
See in Reactome
R-HSA-2468287
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-2468287
Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres
See in Reactome
R-HSA-2484822
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-375302
(
R-HSA-68877
)
R-HSA-375302
Reaction Name: Kinetochore capture of astral microtubules
See in Reactome
R-HSA-5666129
(
R-HSA-5663220
)
R-HSA-5666129
Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores
See in Reactome
R-HSA-5666160
(
R-HSA-5663220
)
R-HSA-5666160
Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores
See in Reactome
R-HSA-5666169
(
R-HSA-5663220
)
R-HSA-5666169
Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
See in Reactome
R-HSA-9648114
(
R-HSA-68877;
R-HSA-9648025
)
R-HSA-9648114
Reaction Name: EML4 recruits NUDC to mitotic spindle
See in Reactome
|
MONDO:0016996 |
AURKB |
Q96GD4 |
2.7.11.1
|
R-HSA-5663220
R-HSA-2500257
R-HSA-2500257
Reactome Name: Resolution of Sister Chromatid Cohesion
See in Reactome
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-9022692
R-HSA-9022692
Reactome Name: Regulation of MECP2 expression and activity
See in Reactome
R-HSA-4615885
R-HSA-4615885
Reactome Name: SUMOylation of DNA replication proteins
See in Reactome
R-HSA-9648025
R-HSA-9648025
Reactome Name: EML4 and NUDC in mitotic spindle formation
See in Reactome
R-HSA-174178
R-HSA-174178
Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
See in Reactome
R-HSA-141444
R-HSA-141444
Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
See in Reactome
R-HSA-68877
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-194315
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-73857
R-HSA-174143
R-HSA-174143
Reactome Name: APC/C-mediated degradation of cell cycle proteins
See in Reactome
R-HSA-5633007
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-69620
R-HSA-69278
R-HSA-2990846
R-HSA-141424
R-HSA-141424
Reactome Name: Amplification of signal from the kinetochores
See in Reactome
R-HSA-392499
R-HSA-453276
R-HSA-453276
Reactome Name: Regulation of mitotic cell cycle
See in Reactome
R-HSA-68886
R-HSA-68882
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-195258
R-HSA-3108232
R-HSA-3108232
Reactome Name: SUMO E3 ligases SUMOylate target proteins
See in Reactome
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-69618
R-HSA-162582
|
Cell Cycle
Gene expression (Transcription)
Metabolism of proteins
Signal Transduction
|
R-HSA-141409
(
R-HSA-141444
)
R-HSA-141422
(
R-HSA-141444
)
R-HSA-141422
Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1
See in Reactome
R-HSA-141431
(
R-HSA-141444
)
R-HSA-141431
Reaction Name: MAD2 associates with the Mad1 kinetochore complex
See in Reactome
R-HSA-141439
(
R-HSA-141444
)
R-HSA-141439
Reaction Name: Release of activated MAD2 from kinetochores
See in Reactome
R-HSA-1638803
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638803
Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres
See in Reactome
R-HSA-1638821
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638821
Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin
See in Reactome
R-HSA-174088
(
R-HSA-174178
)
R-HSA-174088
Reaction Name: Association of cell cycle proteins with the APC/C:Cdh1 complex
See in Reactome
R-HSA-174105
(
R-HSA-174178
)
R-HSA-174105
Reaction Name: Degradation of multiubiquitinated cell cycle proteins
See in Reactome
R-HSA-174195
(
R-HSA-174178
)
R-HSA-174195
Reaction Name: Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex
See in Reactome
R-HSA-2467809
(
R-HSA-2467813
)
R-HSA-2467809
Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin
See in Reactome
R-HSA-2467811
(
R-HSA-2467813
)
R-HSA-2467811
Reaction Name: Separation of sister chromatids
See in Reactome
R-HSA-2468287
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-2468287
Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres
See in Reactome
R-HSA-2484822
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-375302
(
R-HSA-68877
)
R-HSA-375302
Reaction Name: Kinetochore capture of astral microtubules
See in Reactome
R-HSA-4655355
(
R-HSA-4615885
)
R-HSA-4655355
Reaction Name: RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)
See in Reactome
R-HSA-5666129
(
R-HSA-5663220
)
R-HSA-5666129
Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores
See in Reactome
R-HSA-5666160
(
R-HSA-5663220
)
R-HSA-5666160
Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores
See in Reactome
R-HSA-5666169
(
R-HSA-5663220
)
R-HSA-5666169
Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
See in Reactome
R-HSA-6805122
(
R-HSA-6804756
)
R-HSA-6805126
(
R-HSA-6804756
)
R-HSA-9023132
(
R-HSA-9022692
)
R-HSA-9023132
Reaction Name: AURKB phosphorylates MECP2 at S423
See in Reactome
R-HSA-9648114
(
R-HSA-68877;
R-HSA-9648025
)
R-HSA-9648114
Reaction Name: EML4 recruits NUDC to mitotic spindle
See in Reactome
|
MONDO:0018908 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0019086 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0021100 |
MONDO:0021100
Disease Name: breast neoplasm
All associated enzymes in DAR:
FGFR2
MTOR
FGFR4
ROCK1
RHOA
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0030913 |
RAC1 |
P63000 |
3.6.5.2
|
R-HSA-376172
R-HSA-445144
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-9619229
R-HSA-9619229
Reactome Name: Activation of RAC1 downstream of NMDARs
See in Reactome
R-HSA-428540
R-HSA-428543
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-399954
R-HSA-399954
Reactome Name: Sema3A PAK dependent Axon repulsion
See in Reactome
R-HSA-9032845
R-HSA-9032845
Reactome Name: Activated NTRK2 signals through CDK5
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-6798695
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-193648
R-HSA-193648
Reactome Name: NRAGE signals death through JNK
See in Reactome
R-HSA-5625900
R-HSA-5625740
R-HSA-9032759
R-HSA-1257604
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-389359
R-HSA-5627123
R-HSA-399955
R-HSA-399955
Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
See in Reactome
R-HSA-5626467
R-HSA-4420097
R-HSA-5663220
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5687128
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1433557
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-2424491
R-HSA-9013149
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-8875555
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-3928664
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-8848021
R-HSA-1280218
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9675108
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-112316
R-HSA-8875878
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-373760
R-HSA-9032500
R-HSA-9032500
Reactome Name: Activated NTRK2 signals through FYN
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-168249
R-HSA-195258
R-HSA-199991
R-HSA-73887
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-2682334
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-5653656
R-HSA-6806834
R-HSA-195721
R-HSA-2172127
R-HSA-204998
R-HSA-204998
Reactome Name: Cell death signalling via NRAGE, NRIF and NADE
See in Reactome
R-HSA-373755
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
|
Immune System
Developmental Biology
Neuronal System
Vesicle-mediated transport
Hemostasis
Signal Transduction
|
R-HSA-1011598
(
R-HSA-983231
)
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1433415
(
R-HSA-1433557
)
R-HSA-2029451
(
R-HSA-2029482
)
R-HSA-2029454
(
R-HSA-2029482
)
R-HSA-2029456
(
R-HSA-2029482;
R-HSA-5627123
)
R-HSA-2029465
(
R-HSA-2029482;
R-HSA-4420097;
R-HSA-5663213
)
R-HSA-2029465
Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)
See in Reactome
R-HSA-2029466
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029466
Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin
See in Reactome
R-HSA-2029467
(
R-HSA-2029482
)
R-HSA-2029467
Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO
See in Reactome
R-HSA-2029469
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029469
Reaction Name: p-ERK phosphorylates WAVEs and ABI
See in Reactome
R-HSA-205039
(
R-HSA-193648
)
R-HSA-205039
Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
See in Reactome
R-HSA-205136
(
R-HSA-193648
)
R-HSA-205136
Reaction Name: GTP-bound RAC contributes to JNK activation
See in Reactome
R-HSA-2130194
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2197690
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2316352
(
R-HSA-1445148
)
R-HSA-2316352
Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424476
(
R-HSA-2424491
)
R-HSA-2730840
(
R-HSA-2871796
)
R-HSA-2730856
(
R-HSA-2871796
)
R-HSA-2730889
(
R-HSA-2871796
)
R-HSA-2730889
Reaction Name: Recruitment of PAK to the membrane by binding active RAC1
See in Reactome
R-HSA-376123
(
R-HSA-376172
)
R-HSA-376123
Reaction Name: DSCAM associates with Rac1-GTP:pPAK1
See in Reactome
R-HSA-3858475
(
R-HSA-4086400
)
R-HSA-389348
(
R-HSA-389359
)
R-HSA-389788
(
R-HSA-389359;
R-HSA-5687128
)
R-HSA-389788
Reaction Name: Activation of PAKs by RAC1 and CDC42
See in Reactome
R-HSA-3928612
(
R-HSA-3928662
)
R-HSA-3928612
Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928619
(
R-HSA-3928662
)
R-HSA-3928620
(
R-HSA-3928662
)
R-HSA-3928625
(
R-HSA-3928664
)
R-HSA-3928628
(
R-HSA-3928665
)
R-HSA-3928628
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928633
(
R-HSA-3928664
)
R-HSA-3928633
Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it
See in Reactome
R-HSA-3928640
(
R-HSA-3928664
)
R-HSA-3928641
(
R-HSA-3928664
)
R-HSA-3928642
(
R-HSA-3928665
)
R-HSA-3928642
Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-399928
(
R-HSA-399955
)
R-HSA-399928
Reaction Name: Recruitment of Rnd1 to Plexin A
See in Reactome
R-HSA-399930
(
R-HSA-399954
)
R-HSA-399935
(
R-HSA-399955
)
R-HSA-399935
Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity
See in Reactome
R-HSA-399938
(
R-HSA-399955
)
R-HSA-399939
(
R-HSA-399954
)
R-HSA-399941
(
R-HSA-399955
)
R-HSA-399952
(
R-HSA-399954
)
R-HSA-399952
Reaction Name: Phosphorylation of LIMK-1 by PAK
See in Reactome
R-HSA-400682
(
R-HSA-416550
)
R-HSA-400682
Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D
See in Reactome
R-HSA-4093336
(
R-HSA-3928662
)
R-HSA-4093336
Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-428522
(
R-HSA-428543
)
R-HSA-428535
(
R-HSA-428540
)
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442592
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-442592
Reaction Name: WASPs or WAVEs activate the ARP2/3 complex
See in Reactome
R-HSA-445064
(
R-HSA-445144
)
R-HSA-445072
(
R-HSA-445144
)
R-HSA-445072
Reaction Name: Interaction of PAK1 with Rac1-GTP
See in Reactome
R-HSA-451347
(
R-HSA-376172
)
R-HSA-451366
(
R-HSA-376172
)
R-HSA-5218827
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218827
Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1
See in Reactome
R-HSA-5218839
(
R-HSA-4420097
)
R-HSA-5218839
Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1
See in Reactome
R-HSA-5218841
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218841
Reaction Name: NADPH oxidase 2 generates superoxide from oxygen
See in Reactome
R-HSA-5218850
(
R-HSA-4420097
)
R-HSA-5218850
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-5357445
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357472
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357483
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5626469
(
R-HSA-5626467
)
R-HSA-5626469
Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs
See in Reactome
R-HSA-5626507
(
R-HSA-5626467
)
R-HSA-5626507
Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin
See in Reactome
R-HSA-5626549
(
R-HSA-5626467
)
R-HSA-5627775
(
R-HSA-5627123;
R-HSA-5687128
)
R-HSA-5627775
Reaction Name: Autophosphorylation of PAK1,2,3
See in Reactome
R-HSA-5663232
(
R-HSA-5663220
)
R-HSA-5665659
(
R-HSA-5663220
)
R-HSA-5665659
Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin
See in Reactome
R-HSA-5665802
(
R-HSA-5663220
)
R-HSA-5665802
Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin
See in Reactome
R-HSA-5665809
(
R-HSA-5663220
)
R-HSA-5665809
Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments
See in Reactome
R-HSA-5668714
(
R-HSA-5668599
)
R-HSA-5668718
(
R-HSA-5668599
)
R-HSA-5668718
Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen
See in Reactome
R-HSA-5668731
(
R-HSA-5668599
)
R-HSA-5668731
Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen
See in Reactome
R-HSA-5668735
(
R-HSA-5668599
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5672304
(
R-HSA-5626467
)
R-HSA-5672304
Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1
See in Reactome
R-HSA-5672329
(
R-HSA-5626467
)
R-HSA-5672329
Reaction Name: IQGAP1 binds CLIP1 and microtubules
See in Reactome
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8848618
(
R-HSA-8849471
)
R-HSA-8848618
Reaction Name: Activation of RAC1 by the PXN:CRK complex
See in Reactome
R-HSA-8875591
(
R-HSA-8875555
)
R-HSA-8951586
(
R-HSA-4420097
)
R-HSA-8951586
Reaction Name: p-VAV family:PIP3 binds RAC1:GDP
See in Reactome
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981926
(
R-HSA-5627123
)
R-HSA-8981931
(
R-HSA-5627123
)
R-HSA-9013143
(
R-HSA-9013149
)
R-HSA-9013144
(
R-HSA-9013149
)
R-HSA-9013144
Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9013147
(
R-HSA-9013149
)
R-HSA-9013147
Reaction Name: RAC1 GDIs block activation of RAC1
See in Reactome
R-HSA-9032798
(
R-HSA-9032759
)
R-HSA-9033292
(
R-HSA-9032845
)
R-HSA-9033292
Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1
See in Reactome
R-HSA-9619803
(
R-HSA-9619229
)
R-HSA-9691168
(
R-HSA-9013149
)
R-HSA-9691168
Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane
See in Reactome
R-HSA-9691174
(
R-HSA-9013149
)
R-HSA-9691174
Reaction Name: RAC1 binds effectors at the ER membrane
See in Reactome
|
MONDO:0032697 |
PPP2CA |
P67775 |
3.1.3.16
|
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-198753
R-HSA-2995383
R-HSA-2995383
Reactome Name: Initiation of Nuclear Envelope (NE) Reformation
See in Reactome
R-HSA-4641262
R-HSA-4641262
Reactome Name: Disassembly of the destruction complex and recruitment of AXIN to the membrane
See in Reactome
R-HSA-5673000
R-HSA-180024
R-HSA-2500257
R-HSA-2500257
Reactome Name: Resolution of Sister Chromatid Cohesion
See in Reactome
R-HSA-2465910
R-HSA-2465910
Reactome Name: MASTL Facilitates Mitotic Progression
See in Reactome
R-HSA-9648025
R-HSA-9648025
Reactome Name: EML4 and NUDC in mitotic spindle formation
See in Reactome
R-HSA-389513
R-HSA-196299
R-HSA-196299
Reactome Name: Beta-catenin phosphorylation cascade
See in Reactome
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-432142
R-HSA-113501
R-HSA-113501
Reactome Name: Inhibition of replication initiation of damaged DNA by RB1/E2F1
See in Reactome
R-HSA-141444
R-HSA-141444
Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
See in Reactome
R-HSA-5663220
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-9634600
R-HSA-9634600
Reactome Name: Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-163685
R-HSA-163685
Reactome Name: Integration of energy metabolism
See in Reactome
R-HSA-69273
R-HSA-69273
Reactome Name: Cyclin A/B1/B2 associated events during G2/M transition
See in Reactome
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-163767
R-HSA-163767
Reactome Name: PP2A-mediated dephosphorylation of key metabolic factors
See in Reactome
R-HSA-195253
R-HSA-195253
Reactome Name: Degradation of beta-catenin by the destruction complex
See in Reactome
R-HSA-975957
R-HSA-975957
Reactome Name: Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-202670
R-HSA-68877
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-70326
R-HSA-449147
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-418594
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-194315
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-195258
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-1257604
R-HSA-1640170
R-HSA-5684996
R-HSA-1280218
R-HSA-5673001
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-450282
R-HSA-450282
Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases
See in Reactome
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-71387
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-69620
R-HSA-69236
R-HSA-69278
R-HSA-198725
R-HSA-198725
Reactome Name: Nuclear Events (kinase and transcription factor activation)
See in Reactome
R-HSA-448424
R-HSA-418346
R-HSA-388396
R-HSA-166166
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-73857
R-HSA-5654743
R-HSA-69275
R-HSA-5654741
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-190236
R-HSA-141424
R-HSA-141424
Reactome Name: Amplification of signal from the kinetochores
See in Reactome
R-HSA-168256
R-HSA-8953854
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
R-HSA-453274
R-HSA-68886
R-HSA-70171
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-68882
R-HSA-2995410
R-HSA-2995410
Reactome Name: Nuclear Envelope (NE) Reassembly
See in Reactome
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-168898
R-HSA-187037
R-HSA-5633007
R-HSA-450294
R-HSA-195721
R-HSA-166520
R-HSA-372790
R-HSA-5654738
R-HSA-69206
R-HSA-5654736
R-HSA-111885
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-109582
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-113510
R-HSA-113510
Reactome Name: E2F mediated regulation of DNA replication
See in Reactome
R-HSA-927802
R-HSA-69618
R-HSA-162582
R-HSA-68875
|
Metabolism
Cell Cycle
Gene expression (Transcription)
Immune System
Metabolism of RNA
Hemostasis
Signal Transduction
|
R-HSA-113503
(
R-HSA-113501
)
R-HSA-113503
Reaction Name: PP2A mediated localization of RB1 protein in chromatin
See in Reactome
R-HSA-1295599
(
R-HSA-1295596
)
R-HSA-1295599
Reaction Name: SPRY2 translocates to the plasma membrane
See in Reactome
R-HSA-1295609
(
R-HSA-1295596
)
R-HSA-1295609
Reaction Name: SRC phosphorylates SPRY2 on Y55 and Y227
See in Reactome
R-HSA-1295613
(
R-HSA-1295596
)
R-HSA-1295622
(
R-HSA-1295596
)
R-HSA-1295632
(
R-HSA-1295596
)
R-HSA-1363274
(
R-HSA-69231
)
R-HSA-1363274
Reaction Name: Dephosphorylation of p107 (RBL1) by PP2A
See in Reactome
R-HSA-1363276
(
R-HSA-69231
)
R-HSA-1363276
Reaction Name: Dephosphorylation of p130 (RBL2) by PP2A
See in Reactome
R-HSA-141409
(
R-HSA-141444
)
R-HSA-141422
(
R-HSA-141444
)
R-HSA-141422
Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1
See in Reactome
R-HSA-141431
(
R-HSA-141444
)
R-HSA-141431
Reaction Name: MAD2 associates with the Mad1 kinetochore complex
See in Reactome
R-HSA-141439
(
R-HSA-141444
)
R-HSA-141439
Reaction Name: Release of activated MAD2 from kinetochores
See in Reactome
R-HSA-1549564
(
R-HSA-1295596
)
R-HSA-163688
(
R-HSA-163685;
R-HSA-163767
)
R-HSA-163688
Reaction Name: Dephosphorylation of pChREBP (Thr 666) by PP2A
See in Reactome
R-HSA-163689
(
R-HSA-163685;
R-HSA-163767
)
R-HSA-163689
Reaction Name: Dephosphorylation of pChREBP (Ser 196) by PP2A
See in Reactome
R-HSA-163750
(
R-HSA-163685;
R-HSA-163767;
R-HSA-9634600
)
R-HSA-163750
Reaction Name: Dephosphorylation of phosphoPFKFB1 by PP2A complex
See in Reactome
R-HSA-163769
(
R-HSA-163685
)
R-HSA-163769
Reaction Name: Activation of PP2A by Xylulose-5-phosphate
See in Reactome
R-HSA-1638803
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638803
Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres
See in Reactome
R-HSA-1638821
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638821
Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin
See in Reactome
R-HSA-164056
(
R-HSA-163685;
R-HSA-163767
)
R-HSA-164056
Reaction Name: Dephosphorylation of pChREBP (Ser 568) by PP2A
See in Reactome
R-HSA-195251
(
R-HSA-195253
)
R-HSA-195251
Reaction Name: Assembly of the destruction complex
See in Reactome
R-HSA-195275
(
R-HSA-195253
)
R-HSA-195275
Reaction Name: Phosphorylation of APC component of the destruction complex
See in Reactome
R-HSA-195280
(
R-HSA-195253
)
R-HSA-195280
Reaction Name: Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex
See in Reactome
R-HSA-195283
(
R-HSA-195253;
R-HSA-196299
)
R-HSA-195283
Reaction Name: Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3
See in Reactome
R-HSA-195287
(
R-HSA-195253;
R-HSA-196299
)
R-HSA-195287
Reaction Name: Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3
See in Reactome
R-HSA-195300
(
R-HSA-195253;
R-HSA-196299
)
R-HSA-195300
Reaction Name: Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3
See in Reactome
R-HSA-195304
(
R-HSA-195253
)
R-HSA-195304
Reaction Name: Association of beta-catenin with the destruction complex
See in Reactome
R-HSA-195318
(
R-HSA-195253;
R-HSA-196299
)
R-HSA-195318
Reaction Name: Phosphorylation of beta-catenin at Ser45 by CK1 alpha
See in Reactome
R-HSA-199959
(
R-HSA-198753;
R-HSA-202670
)
R-HSA-199959
Reaction Name: ERKs are inactivated by protein phosphatase 2A
See in Reactome
R-HSA-201685
(
R-HSA-4641262
)
R-HSA-201685
Reaction Name: Beta-catenin is released from the destruction complex
See in Reactome
R-HSA-201790
(
R-HSA-180024
)
R-HSA-201790
Reaction Name: DARPP-32 is dephosphorylated on Thr75 by PP2A
See in Reactome
R-HSA-2130279
(
R-HSA-195253
)
R-HSA-2130279
Reaction Name: Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex
See in Reactome
R-HSA-2130282
(
R-HSA-195253
)
R-HSA-2130282
Reaction Name: Degradation of ubiquitinated beta catenin by the proteasome
See in Reactome
R-HSA-2130286
(
R-HSA-195253
)
R-HSA-2130286
Reaction Name: Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)
See in Reactome
R-HSA-2430552
(
R-HSA-2465910
)
R-HSA-2430552
Reaction Name: p-S62-ARPP19/p-S67-ENSA binds PP2A-PPP2R2D
See in Reactome
R-HSA-2467809
(
R-HSA-2467813
)
R-HSA-2467809
Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin
See in Reactome
R-HSA-2467811
(
R-HSA-2467813
)
R-HSA-2467811
Reaction Name: Separation of sister chromatids
See in Reactome
R-HSA-2468287
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-2468287
Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres
See in Reactome
R-HSA-2484822
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-2995388
(
R-HSA-2995383
)
R-HSA-3601585
(
R-HSA-4641262
)
R-HSA-3601585
Reaction Name: PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex
See in Reactome
R-HSA-375302
(
R-HSA-68877
)
R-HSA-375302
Reaction Name: Kinetochore capture of astral microtubules
See in Reactome
R-HSA-388809
(
R-HSA-389513
)
R-HSA-388833
(
R-HSA-389513
)
R-HSA-389532
(
R-HSA-389513
)
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-4088141
(
R-HSA-69273
)
R-HSA-4088141
Reaction Name: PP2A-PPP2R2A dephosphorylates FOXM1
See in Reactome
R-HSA-432143
(
R-HSA-432142
)
R-HSA-5229343
(
R-HSA-195253
)
R-HSA-5229343
Reaction Name: AXIN is phosphorylated in the destruction complex
See in Reactome
R-HSA-5666129
(
R-HSA-5663220
)
R-HSA-5666129
Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores
See in Reactome
R-HSA-5666160
(
R-HSA-5663220
)
R-HSA-5666160
Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores
See in Reactome
R-HSA-5666169
(
R-HSA-5663220
)
R-HSA-5666169
Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
See in Reactome
R-HSA-5672957
(
R-HSA-5673000
)
R-HSA-5672961
(
R-HSA-5673000
)
R-HSA-5672961
Reaction Name: PP2A dephosphorylates inactive RAFs
See in Reactome
R-HSA-5675431
(
R-HSA-5675221
)
R-HSA-6792863
(
R-HSA-6804757
)
R-HSA-6792863
Reaction Name: PP2A-PP2R5C dephosphorylates MDM2
See in Reactome
R-HSA-6792871
(
R-HSA-6804757
)
R-HSA-6792871
Reaction Name: CCNG1 recruits PP2A-PPP2R5C to MDM2
See in Reactome
R-HSA-6811454
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-6811472
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-6811472
Reaction Name: IER3 recruits MAPKs to PP2A-B56-beta,gamma
See in Reactome
R-HSA-6811504
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-6811504
Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma
See in Reactome
R-HSA-8856945
(
R-HSA-69273
)
R-HSA-8856951
(
R-HSA-69273
)
R-HSA-8857925
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-8857925
Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307
See in Reactome
R-HSA-927813
(
R-HSA-975957
)
R-HSA-927813
Reaction Name: p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A
See in Reactome
R-HSA-927830
(
R-HSA-975957
)
R-HSA-927830
Reaction Name: Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex
See in Reactome
R-HSA-927836
(
R-HSA-975957
)
R-HSA-927836
Reaction Name: SMG6 hydrolyzes mRNA with premature termination codon
See in Reactome
R-HSA-934559
(
R-HSA-1295596
)
R-HSA-934559
Reaction Name: SPRY2 is phosphorylated by phosphorylated MNK1
See in Reactome
R-HSA-9648114
(
R-HSA-68877;
R-HSA-9648025
)
R-HSA-9648114
Reaction Name: EML4 recruits NUDC to mitotic spindle
See in Reactome
R-HSA-9667965
(
R-HSA-2995383
)
|
MONDO:0032884 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0035124 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0044903 |
MONDO:0044903
Disease Name: myelofibrosis
All associated enzymes in DAR:
SRC
SRC |
P12931 |
2.7.10.2
|
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-171007
R-HSA-428542
R-HSA-428542
Reactome Name: Regulation of commissural axon pathfinding by SLIT and ROBO
See in Reactome
R-HSA-418594
R-HSA-8940973
R-HSA-8940973
Reactome Name: RUNX2 regulates osteoblast differentiation
See in Reactome
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-437239
R-HSA-418592
R-HSA-418592
Reactome Name: ADP signalling through P2Y purinoceptor 1
See in Reactome
R-HSA-430116
R-HSA-430116
Reactome Name: GP1b-IX-V activation signalling
See in Reactome
R-HSA-5663220
R-HSA-186763
R-HSA-180292
R-HSA-8941858
R-HSA-8941858
Reactome Name: Regulation of RUNX3 expression and activity
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-418555
R-HSA-5673000
R-HSA-9032500
R-HSA-9032500
Reactome Name: Activated NTRK2 signals through FYN
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-8934903
R-HSA-8853659
R-HSA-372708
R-HSA-372708
Reactome Name: p130Cas linkage to MAPK signaling for integrins
See in Reactome
R-HSA-389356
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-4420097
R-HSA-1433559
R-HSA-2029481
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-1433557
R-HSA-9620244
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-5607764
R-HSA-5674135
R-HSA-8874081
R-HSA-1253288
R-HSA-1253288
Reactome Name: Downregulation of ERBB4 signaling
See in Reactome
R-HSA-2682334
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-177929
R-HSA-1251985
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-354194
R-HSA-354194
Reactome Name: GRB2:SOS provides linkage to MAPK signaling for Integrins
See in Reactome
R-HSA-3928664
R-HSA-456926
R-HSA-456926
Reactome Name: Thrombin signalling through proteinase activated receptors (PARs)
See in Reactome
R-HSA-354192
R-HSA-201556
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-191650
R-HSA-191650
Reactome Name: Regulation of gap junction activity
See in Reactome
R-HSA-9013420
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-1227986
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-376176
R-HSA-9012999
R-HSA-8941326
R-HSA-8941326
Reactome Name: RUNX2 regulates bone development
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-195258
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-1640170
R-HSA-373760
R-HSA-5684996
R-HSA-1280218
R-HSA-1266738
R-HSA-5673001
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-9612973
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-5205647
R-HSA-388396
R-HSA-112316
R-HSA-162582
R-HSA-8875878
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-9675108
R-HSA-168249
R-HSA-9663891
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-392518
R-HSA-8939211
R-HSA-157858
R-HSA-157858
Reactome Name: Gap junction trafficking and regulation
See in Reactome
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-1236394
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-5653656
R-HSA-1632852
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-73857
R-HSA-5654736
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-9034015
R-HSA-186797
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-167044
R-HSA-373752
|
Immune System
Cell-Cell communication
Cell Cycle
Developmental Biology
Autophagy
Gene expression (Transcription)
Neuronal System
Signal Transduction
Vesicle-mediated transport
Hemostasis
|
R-HSA-1252013
(
R-HSA-1251985
)
R-HSA-1252013
Reaction Name: Translocation of ERBB4s80 to the nucleus
See in Reactome
R-HSA-177923
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-186819
(
R-HSA-186763
)
R-HSA-186819
Reaction Name: SH2 domain of Src binds to the active receptor
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-354066
(
R-HSA-354192
)
R-HSA-354066
Reaction Name: Translocation of PTK2 to Focal complexes
See in Reactome
R-HSA-354073
(
R-HSA-354192
)
R-HSA-354073
Reaction Name: Autophosphorylation of PTK2 at Y397
See in Reactome
R-HSA-354077
(
R-HSA-354192
)
R-HSA-354077
Reaction Name: Integrin alphaIIb beta3 activation
See in Reactome
R-HSA-354087
(
R-HSA-354192;
R-HSA-354194
)
R-HSA-354124
(
R-HSA-354192
)
R-HSA-354124
Reaction Name: Phosphorylation of pPTK2 by SRC
See in Reactome
R-HSA-354149
(
R-HSA-354192
)
R-HSA-354149
Reaction Name: Interaction of integrin alphaIIb beta3 with Fibrinogen
See in Reactome
R-HSA-354165
(
R-HSA-354192;
R-HSA-354194
)
R-HSA-354165
Reaction Name: Interaction of SOS with GRB2 bound to FADK1
See in Reactome
R-HSA-372693
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372693
Reaction Name: Phosphorylation of BCAR1 by SRC-PTK2 complex
See in Reactome
R-HSA-372697
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372705
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372705
Reaction Name: Recruitment of BCAR1 to PTK2 complex
See in Reactome
R-HSA-373716
(
R-HSA-418885
)
R-HSA-374701
(
R-HSA-418885
)
R-HSA-377640
(
R-HSA-354192
)
R-HSA-377641
(
R-HSA-354192
)
R-HSA-377641
Reaction Name: Clustering of Integrin alphaIIb beta3 complexes
See in Reactome
R-HSA-377643
(
R-HSA-354192
)
R-HSA-377643
Reaction Name: Dephosphorylation of inactive SRC by PTPB1
See in Reactome
R-HSA-377644
(
R-HSA-354192
)
R-HSA-380780
(
R-HSA-186763
)
R-HSA-418850
(
R-HSA-418885
)
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418858
(
R-HSA-418885
)
R-HSA-418858
Reaction Name: RhoGTPase GEF's recruited to DCC
See in Reactome
R-HSA-418859
(
R-HSA-418886
)
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-418868
(
R-HSA-418885
)
R-HSA-418868
Reaction Name: Recruitment of Src and Fyn to DCC:FADK1
See in Reactome
R-HSA-418874
(
R-HSA-418885
)
R-HSA-418874
Reaction Name: Recruitment and activation of N-WASP by Cdc42
See in Reactome
R-HSA-429415
(
R-HSA-354192
)
R-HSA-429415
Reaction Name: SYK binds to integrin alphaIIb beta3
See in Reactome
R-HSA-429441
(
R-HSA-354192
)
R-HSA-432096
(
R-HSA-354192
)
R-HSA-432096
Reaction Name: Activated integrin alphaIIb beta3 binds SHC1
See in Reactome
R-HSA-443905
(
R-HSA-354192
)
R-HSA-443905
Reaction Name: SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow
See in Reactome
R-HSA-443910
(
R-HSA-354192
)
R-HSA-443910
Reaction Name: SHC1 dissociates from integrin alphaIIb beta3
See in Reactome
R-HSA-5672969
(
R-HSA-5673000
)
R-HSA-5672972
(
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-8874080
(
R-HSA-8874081
)
R-HSA-8874082
(
R-HSA-8874081
)
R-HSA-8874083
(
R-HSA-8874081
)
R-HSA-8937682
(
R-HSA-8934593
)
R-HSA-8937728
(
R-HSA-8934593
)
R-HSA-8937792
(
R-HSA-8941858
)
R-HSA-8937807
(
R-HSA-8941858
)
R-HSA-8937814
(
R-HSA-8941858
)
R-HSA-8937814
Reaction Name: RUNX3 translocates to the nucleus
See in Reactome
R-HSA-8937820
(
R-HSA-8940973
)
R-HSA-8937844
(
R-HSA-8940973
)
R-HSA-8964242
(
R-HSA-418594
)
R-HSA-8964242
Reaction Name: G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC
See in Reactome
R-HSA-8964252
(
R-HSA-418555
)
R-HSA-8964252
Reaction Name: G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC
See in Reactome
R-HSA-8964278
(
R-HSA-418555
)
R-HSA-8964278
Reaction Name: G protein alpha (s):GTP binds SRC
See in Reactome
R-HSA-8964287
(
R-HSA-418555
)
R-HSA-8964287
Reaction Name: G alpha (s):GTP:SRC dissociates
See in Reactome
R-HSA-8964311
(
R-HSA-418594
)
R-HSA-8964329
(
R-HSA-418594
)
R-HSA-8964329
Reaction Name: G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC
See in Reactome
R-HSA-9011241
(
R-HSA-428542
)
R-HSA-9011241
Reaction Name: SRC phosphorylates ROBO3.1 in response to NTN1
See in Reactome
R-HSA-9021596
(
R-HSA-9009391
)
R-HSA-9021596
Reaction Name: Membrane estrogen receptors bind SRC
See in Reactome
R-HSA-9021609
(
R-HSA-9009391
)
R-HSA-9021609
Reaction Name: ESR-associated SRC autophosphorylates
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9037040
(
R-HSA-9032500
)
R-HSA-9603419
(
R-HSA-9603381
)
R-HSA-9603420
(
R-HSA-9603381
)
R-HSA-9603420
Reaction Name: Activated NTRK3 promotes SRC autophosphorylation
See in Reactome
R-HSA-9603437
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9612085
(
R-HSA-9620244
)
R-HSA-9612085
Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs
See in Reactome
R-HSA-9612219
(
R-HSA-1253288
)
R-HSA-9624014
(
R-HSA-418555
)
R-HSA-9624014
Reaction Name: SHC1 is phosphorylated downstream of estrogen stimulation of GPER1
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9657599
(
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9726848
(
R-HSA-9013420
)
|
OMIM:619575 |
TAOK1 |
Q7L7X3 |
2.7.11.1
|
R-HSA-5663220
R-HSA-2500257
R-HSA-2500257
Reactome Name: Resolution of Sister Chromatid Cohesion
See in Reactome
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-9648025
R-HSA-9648025
Reactome Name: EML4 and NUDC in mitotic spindle formation
See in Reactome
R-HSA-141444
R-HSA-141444
Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
See in Reactome
R-HSA-68877
|
R-HSA-195258
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-141424
R-HSA-141424
Reactome Name: Amplification of signal from the kinetochores
See in Reactome
R-HSA-194315
R-HSA-69620
R-HSA-68886
R-HSA-69278
R-HSA-68882
R-HSA-1640170
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-69618
R-HSA-162582
|
Cell Cycle
Signal Transduction
|
R-HSA-141409
(
R-HSA-141444
)
R-HSA-141422
(
R-HSA-141444
)
R-HSA-141422
Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1
See in Reactome
R-HSA-141431
(
R-HSA-141444
)
R-HSA-141431
Reaction Name: MAD2 associates with the Mad1 kinetochore complex
See in Reactome
R-HSA-141439
(
R-HSA-141444
)
R-HSA-141439
Reaction Name: Release of activated MAD2 from kinetochores
See in Reactome
R-HSA-1638803
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638803
Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres
See in Reactome
R-HSA-1638821
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638821
Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin
See in Reactome
R-HSA-2467809
(
R-HSA-2467813
)
R-HSA-2467809
Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin
See in Reactome
R-HSA-2467811
(
R-HSA-2467813
)
R-HSA-2467811
Reaction Name: Separation of sister chromatids
See in Reactome
R-HSA-2468287
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-2468287
Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres
See in Reactome
R-HSA-2484822
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-375302
(
R-HSA-68877
)
R-HSA-375302
Reaction Name: Kinetochore capture of astral microtubules
See in Reactome
R-HSA-5666129
(
R-HSA-5663220
)
R-HSA-5666129
Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores
See in Reactome
R-HSA-5666160
(
R-HSA-5663220
)
R-HSA-5666160
Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores
See in Reactome
R-HSA-5666169
(
R-HSA-5663220
)
R-HSA-5666169
Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
See in Reactome
R-HSA-9648114
(
R-HSA-68877;
R-HSA-9648025
)
R-HSA-9648114
Reaction Name: EML4 recruits NUDC to mitotic spindle
See in Reactome
|