DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-5660668)

Number of enzymes:	2
Number of disease:	3
Number of reactomes:	24
Number of reactions:	65

Search results (Reactome ID: R-HSA-5660668)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0011804	CASP8	Q14790	3.4.22.61	R-HSA-75153 R-HSA-75153 Reactome Name: Apoptotic execution phase See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-75158 R-HSA-75158 Reactome Name: TRAIL signaling See in Reactome R-HSA-75108 R-HSA-75108 Reactome Name: Activation, myristolyation of BID and translocation to mitochondria See in Reactome R-HSA-9686347 R-HSA-9686347 Reactome Name: Microbial modulation of RIPK1-mediated regulated necrosis See in Reactome R-HSA-264870 R-HSA-264870 Reactome Name: Caspase-mediated cleavage of cytoskeletal proteins See in Reactome R-HSA-111465 R-HSA-111465 Reactome Name: Apoptotic cleavage of cellular proteins See in Reactome R-HSA-5213460 R-HSA-5213460 Reactome Name: RIPK1-mediated regulated necrosis See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-5660668 R-HSA-5660668 Reactome Name: CLEC7A/inflammasome pathway See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome R-HSA-5218900 R-HSA-5218900 Reactome Name: CASP8 activity is inhibited See in Reactome R-HSA-140534 R-HSA-140534 Reactome Name: Caspase activation via Death Receptors in the presence of ligand See in Reactome R-HSA-2562578 R-HSA-2562578 Reactome Name: TRIF-mediated programmed cell death See in Reactome R-HSA-75157 R-HSA-75157 Reactome Name: FasL/ CD95L signaling See in Reactome R-HSA-69416 R-HSA-69416 Reactome Name: Dimerization of procaspase-8 See in Reactome R-HSA-5675482 R-HSA-5675482 Reactome Name: Regulation of necroptotic cell death See in Reactome R-HSA-3371378 R-HSA-3371378 Reactome Name: Regulation by c-FLIP See in Reactome R-HSA-5357786 R-HSA-5357786 Reactome Name: TNFR1-induced proapoptotic signaling See in Reactome R-HSA-9013957 R-HSA-9013957 Reactome Name: TLR3-mediated TICAM1-dependent programmed cell death See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-5357769 R-HSA-5357769 Reactome Name: Caspase activation via extrinsic apoptotic signalling pathway See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-5218859 R-HSA-5218859 Reactome Name: Regulated Necrosis See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Signal Transduction	R-HSA-139898 ( R-HSA-75108 ) R-HSA-139898 Reaction Name: Caspase-8 activates BID by cleavage See in Reactome R-HSA-139952 ( R-HSA-140534 ) R-HSA-139952 Reaction Name: Caspase-8 processing in the DISC See in Reactome R-HSA-141156 ( R-HSA-140534; R-HSA-69416 ) R-HSA-141156 Reaction Name: TRAIL-mediated dimerization of procaspase-8 See in Reactome R-HSA-141159 ( R-HSA-140534; R-HSA-69416 ) R-HSA-141159 Reaction Name: TNF-mediated dimerization of procaspase-8 See in Reactome R-HSA-201637 ( R-HSA-111465; R-HSA-264870; R-HSA-75153 ) R-HSA-201637 Reaction Name: Caspase-mediated cleavage of plectin-1 See in Reactome R-HSA-2562541 ( R-HSA-2562578 ) R-HSA-2562541 Reaction Name: TLR4-induced ripoptosome assembly See in Reactome R-HSA-2562564 ( R-HSA-140534; R-HSA-2562578 ) R-HSA-2562564 Reaction Name: Caspase-8 processing within TLR4 complex See in Reactome R-HSA-2672196 ( R-HSA-5213460; R-HSA-5218900; R-HSA-5357905; R-HSA-5675482; R-HSA-9686347 ) R-HSA-2672196 Reaction Name: Viral serpin blocks caspase-8 activity See in Reactome R-HSA-3371359 ( R-HSA-140534; R-HSA-3371378 ) R-HSA-3371359 Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling See in Reactome R-HSA-3371360 ( R-HSA-140534; R-HSA-3371378; R-HSA-5357905 ) R-HSA-3371360 Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling See in Reactome R-HSA-3465429 ( R-HSA-5213460; R-HSA-5218900; R-HSA-5675482 ) R-HSA-3465429 Reaction Name: FLIP(S) and procaspase-8 form heterodimer See in Reactome R-HSA-3465448 ( R-HSA-140534; R-HSA-3371378 ) R-HSA-3465448 Reaction Name: Caspase-8 and FLIP(L) processing at DISC See in Reactome R-HSA-3465459 ( R-HSA-140534; R-HSA-3371378 ) R-HSA-3465459 Reaction Name: FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling See in Reactome R-HSA-350319 ( R-HSA-111465; R-HSA-264870; R-HSA-75153 ) R-HSA-350319 Reaction Name: Caspase mediated cleavage of vimentin at IDVD (259) See in Reactome R-HSA-351863 ( R-HSA-75153 ) R-HSA-351863 Reaction Name: Translocation of active caspase-8 to the mitochondrial membrane See in Reactome R-HSA-351894 ( R-HSA-111465; R-HSA-75153 ) R-HSA-351894 Reaction Name: Caspase mediated cleavage of BAP31 See in Reactome R-HSA-5213462 ( R-HSA-5213460 ) R-HSA-5213462 Reaction Name: RIPK3 binds RIPK1 See in Reactome R-HSA-5357828 ( R-HSA-5213460; R-HSA-5357905; R-HSA-5675482 ) R-HSA-5357828 Reaction Name: RIPK1 is cleaved by CASP8 See in Reactome R-HSA-5634228 ( R-HSA-5357905 ) R-HSA-5634228 Reaction Name: TRAF1 is cleaved by caspases See in Reactome R-HSA-5660662 ( R-HSA-5660668 ) R-HSA-5660662 Reaction Name: ASC binds Caspase-8 complex See in Reactome R-HSA-5660663 ( R-HSA-5660668 ) R-HSA-5660663 Reaction Name: Caspase-8 cleaves IL1B precursor See in Reactome R-HSA-5660665 ( R-HSA-5660668 ) R-HSA-5660665 Reaction Name: Caspase-8 binds MALT See in Reactome R-HSA-5675456 ( R-HSA-5213460; R-HSA-5218900; R-HSA-5675482 ) R-HSA-5675456 Reaction Name: FLIP(L) and procaspase-8 form heterodimer See in Reactome R-HSA-5692550 ( R-HSA-5357905 ) R-HSA-5692550 Reaction Name: Viral inhibitor of caspase-8 activation (UL36) binds caspase-8 See in Reactome R-HSA-622420 ( R-HSA-168638 ) R-HSA-622420 Reaction Name: NOD1 induced apoptosis is mediated by RIP2 and CARD8 See in Reactome R-HSA-73945 ( R-HSA-140534; R-HSA-69416 ) R-HSA-73945 Reaction Name: FAS-mediated dimerization of procaspase-8 See in Reactome R-HSA-75146 ( R-HSA-75158 ) R-HSA-75146 Reaction Name: TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 See in Reactome R-HSA-75240 ( R-HSA-5357786 ) R-HSA-75240 Reaction Name: TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8 See in Reactome R-HSA-83586 ( R-HSA-75157 ) R-HSA-83586 Reaction Name: FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 See in Reactome R-HSA-9013889 ( R-HSA-9013957 ) R-HSA-9013889 Reaction Name: TLR3-induced ripoptosome assembly See in Reactome R-HSA-9013895 ( R-HSA-9013957 ) R-HSA-9013895 Reaction Name: Caspase-8 processing within TLR3 complex See in Reactome R-HSA-933523 ( R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933526 ( R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933532 ( R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933539 ( R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-9686930 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9686930 Reaction Name: RIPK3 is cleaved by CASP8 See in Reactome R-HSA-9687458 ( R-HSA-5213460; R-HSA-9686347 ) R-HSA-9687458 Reaction Name: HSV1 RIR1 binds CASP8 See in Reactome R-HSA-9697747 ( R-HSA-5357905 ) R-HSA-9697747 Reaction Name: Caspase-8 and FLIP(L) processing at TNFR signaling complex See in Reactome R-HSA-9697750 ( R-HSA-5357905 ) R-HSA-9697750 Reaction Name: RIPK1 is cleaved by CASP8:FLIP(L) See in Reactome
MONDO:0014197	MALT1	Q9UDY8	3.4.22.-	R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-1169091 R-HSA-1169091 Reactome Name: Activation of NF-kappaB in B cells See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-5660668 R-HSA-5660668 Reactome Name: CLEC7A/inflammasome pathway See in Reactome R-HSA-2871837 R-HSA-2871837 Reactome Name: FCERI mediated NF-kB activation See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome	Immune System	R-HSA-1168637 ( R-HSA-1169091 ) R-HSA-1168637 Reaction Name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK See in Reactome R-HSA-1168641 ( R-HSA-1169091 ) R-HSA-1168641 Reaction Name: TAK1 associated with the CBM complex phosphorylates IKKbeta See in Reactome R-HSA-1168644 ( R-HSA-1169091 ) R-HSA-1168644 Reaction Name: CARMA1 recruits MALT1 and BCL10 forming CBM Complex See in Reactome R-HSA-202453 ( R-HSA-202424 ) R-HSA-202453 Reaction Name: Auto-ubiquitination of TRAF6 See in Reactome R-HSA-202472 ( R-HSA-202424 ) R-HSA-202472 Reaction Name: Translocation of TRAF6 to CBM complex See in Reactome R-HSA-202478 ( R-HSA-202424 ) R-HSA-202478 Reaction Name: Interaction and oligomerization of MALT1 to Bcl10 See in Reactome R-HSA-202500 ( R-HSA-202424 ) R-HSA-202500 Reaction Name: Activation of IKK complex See in Reactome R-HSA-202510 ( R-HSA-202424 ) R-HSA-202510 Reaction Name: Activation of TAK1-TAB2 complex See in Reactome R-HSA-202534 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-202534 Reaction Name: Ubiquitination of NEMO by TRAF6 See in Reactome R-HSA-2730836 ( R-HSA-2871837 ) R-HSA-2730836 Reaction Name: Interaction of BCL10:MALT1 with CARMA1 to form CBM complex See in Reactome R-HSA-2730861 ( R-HSA-2871837 ) R-HSA-2730861 Reaction Name: Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 See in Reactome R-HSA-2730864 ( R-HSA-2871837 ) R-HSA-2730864 Reaction Name: Recruitment of TRAF6 to CBM complex by binding to MALT1 See in Reactome R-HSA-2730876 ( R-HSA-2871837 ) R-HSA-2730876 Reaction Name: Phosphorylation of IKK-beta by TAK1 See in Reactome R-HSA-2730899 ( R-HSA-2871837 ) R-HSA-2730899 Reaction Name: Oligomerization of BCL10 and MALT1 See in Reactome R-HSA-2730900 ( R-HSA-2871837 ) R-HSA-2730900 Reaction Name: Activation of TAK1 complex bound to pUb-TRAF6 See in Reactome R-HSA-2730903 ( R-HSA-2871837 ) R-HSA-2730903 Reaction Name: Oligomerization of TRAF6 See in Reactome R-HSA-2730904 ( R-HSA-2871837 ) R-HSA-2730904 Reaction Name: Auto-ubiquitination of TRAF6 See in Reactome R-HSA-5607732 ( R-HSA-5607764 ) R-HSA-5607732 Reaction Name: K63polyUb-TAK1 autophosphorylates See in Reactome R-HSA-5607736 ( R-HSA-5607764 ) R-HSA-5607736 Reaction Name: MALT1 oligomerizes See in Reactome R-HSA-5607742 ( R-HSA-5607764 ) R-HSA-5607742 Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta See in Reactome R-HSA-5607744 ( R-HSA-5607764 ) R-HSA-5607744 Reaction Name: MALT1 binds BCL10 See in Reactome R-HSA-5607747 ( R-HSA-5607764 ) R-HSA-5607747 Reaction Name: TRAF6 binds MALT1 oligomers See in Reactome R-HSA-5607751 ( R-HSA-5607764 ) R-HSA-5607751 Reaction Name: TRAF6 oligomerizes See in Reactome R-HSA-5607756 ( R-HSA-5607764 ) R-HSA-5607756 Reaction Name: TRAF6 oligomer autoubiquitinates See in Reactome R-HSA-5607757 ( R-HSA-5607764 ) R-HSA-5607757 Reaction Name: K63polyUb-TRAF6 ubiquitinates TAK1 See in Reactome R-HSA-5607759 ( R-HSA-5607764 ) R-HSA-5607759 Reaction Name: TRIKA2 binds K63polyUb-TRAF6 oligomer See in Reactome R-HSA-5660662 ( R-HSA-5607764; R-HSA-5660668 ) R-HSA-5660662 Reaction Name: ASC binds Caspase-8 complex See in Reactome R-HSA-5660663 ( R-HSA-5607764; R-HSA-5660668 ) R-HSA-5660663 Reaction Name: Caspase-8 cleaves IL1B precursor See in Reactome R-HSA-5660665 ( R-HSA-5607764; R-HSA-5660668 ) R-HSA-5660665 Reaction Name: Caspase-8 binds MALT See in Reactome
MONDO:0016216	CASP8	Q14790	3.4.22.61	R-HSA-75153 R-HSA-75153 Reactome Name: Apoptotic execution phase See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-75158 R-HSA-75158 Reactome Name: TRAIL signaling See in Reactome R-HSA-75108 R-HSA-75108 Reactome Name: Activation, myristolyation of BID and translocation to mitochondria See in Reactome R-HSA-9686347 R-HSA-9686347 Reactome Name: Microbial modulation of RIPK1-mediated regulated necrosis See in Reactome R-HSA-264870 R-HSA-264870 Reactome Name: Caspase-mediated cleavage of cytoskeletal proteins See in Reactome R-HSA-111465 R-HSA-111465 Reactome Name: Apoptotic cleavage of cellular proteins See in Reactome R-HSA-5213460 R-HSA-5213460 Reactome Name: RIPK1-mediated regulated necrosis See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-5660668 R-HSA-5660668 Reactome Name: CLEC7A/inflammasome pathway See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome R-HSA-5218900 R-HSA-5218900 Reactome Name: CASP8 activity is inhibited See in Reactome R-HSA-140534 R-HSA-140534 Reactome Name: Caspase activation via Death Receptors in the presence of ligand See in Reactome R-HSA-2562578 R-HSA-2562578 Reactome Name: TRIF-mediated programmed cell death See in Reactome R-HSA-75157 R-HSA-75157 Reactome Name: FasL/ CD95L signaling See in Reactome R-HSA-69416 R-HSA-69416 Reactome Name: Dimerization of procaspase-8 See in Reactome R-HSA-5675482 R-HSA-5675482 Reactome Name: Regulation of necroptotic cell death See in Reactome R-HSA-3371378 R-HSA-3371378 Reactome Name: Regulation by c-FLIP See in Reactome R-HSA-5357786 R-HSA-5357786 Reactome Name: TNFR1-induced proapoptotic signaling See in Reactome R-HSA-9013957 R-HSA-9013957 Reactome Name: TLR3-mediated TICAM1-dependent programmed cell death See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-5357769 R-HSA-5357769 Reactome Name: Caspase activation via extrinsic apoptotic signalling pathway See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-5218859 R-HSA-5218859 Reactome Name: Regulated Necrosis See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Signal Transduction	R-HSA-139898 ( R-HSA-75108 ) R-HSA-139898 Reaction Name: Caspase-8 activates BID by cleavage See in Reactome R-HSA-139952 ( R-HSA-140534 ) R-HSA-139952 Reaction Name: Caspase-8 processing in the DISC See in Reactome R-HSA-141156 ( R-HSA-140534; R-HSA-69416 ) R-HSA-141156 Reaction Name: TRAIL-mediated dimerization of procaspase-8 See in Reactome R-HSA-141159 ( R-HSA-140534; R-HSA-69416 ) R-HSA-141159 Reaction Name: TNF-mediated dimerization of procaspase-8 See in Reactome R-HSA-201637 ( R-HSA-111465; R-HSA-264870; R-HSA-75153 ) R-HSA-201637 Reaction Name: Caspase-mediated cleavage of plectin-1 See in Reactome R-HSA-2562541 ( R-HSA-2562578 ) R-HSA-2562541 Reaction Name: TLR4-induced ripoptosome assembly See in Reactome R-HSA-2562564 ( R-HSA-140534; R-HSA-2562578 ) R-HSA-2562564 Reaction Name: Caspase-8 processing within TLR4 complex See in Reactome R-HSA-2672196 ( R-HSA-5213460; R-HSA-5218900; R-HSA-5357905; R-HSA-5675482; R-HSA-9686347 ) R-HSA-2672196 Reaction Name: Viral serpin blocks caspase-8 activity See in Reactome R-HSA-3371359 ( R-HSA-140534; R-HSA-3371378 ) R-HSA-3371359 Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling See in Reactome R-HSA-3371360 ( R-HSA-140534; R-HSA-3371378; R-HSA-5357905 ) R-HSA-3371360 Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling See in Reactome R-HSA-3465429 ( R-HSA-5213460; R-HSA-5218900; R-HSA-5675482 ) R-HSA-3465429 Reaction Name: FLIP(S) and procaspase-8 form heterodimer See in Reactome R-HSA-3465448 ( R-HSA-140534; R-HSA-3371378 ) R-HSA-3465448 Reaction Name: Caspase-8 and FLIP(L) processing at DISC See in Reactome R-HSA-3465459 ( R-HSA-140534; R-HSA-3371378 ) R-HSA-3465459 Reaction Name: FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling See in Reactome R-HSA-350319 ( R-HSA-111465; R-HSA-264870; R-HSA-75153 ) R-HSA-350319 Reaction Name: Caspase mediated cleavage of vimentin at IDVD (259) See in Reactome R-HSA-351863 ( R-HSA-75153 ) R-HSA-351863 Reaction Name: Translocation of active caspase-8 to the mitochondrial membrane See in Reactome R-HSA-351894 ( R-HSA-111465; R-HSA-75153 ) R-HSA-351894 Reaction Name: Caspase mediated cleavage of BAP31 See in Reactome R-HSA-5213462 ( R-HSA-5213460 ) R-HSA-5213462 Reaction Name: RIPK3 binds RIPK1 See in Reactome R-HSA-5357828 ( R-HSA-5213460; R-HSA-5357905; R-HSA-5675482 ) R-HSA-5357828 Reaction Name: RIPK1 is cleaved by CASP8 See in Reactome R-HSA-5634228 ( R-HSA-5357905 ) R-HSA-5634228 Reaction Name: TRAF1 is cleaved by caspases See in Reactome R-HSA-5660662 ( R-HSA-5660668 ) R-HSA-5660662 Reaction Name: ASC binds Caspase-8 complex See in Reactome R-HSA-5660663 ( R-HSA-5660668 ) R-HSA-5660663 Reaction Name: Caspase-8 cleaves IL1B precursor See in Reactome R-HSA-5660665 ( R-HSA-5660668 ) R-HSA-5660665 Reaction Name: Caspase-8 binds MALT See in Reactome R-HSA-5675456 ( R-HSA-5213460; R-HSA-5218900; R-HSA-5675482 ) R-HSA-5675456 Reaction Name: FLIP(L) and procaspase-8 form heterodimer See in Reactome R-HSA-5692550 ( R-HSA-5357905 ) R-HSA-5692550 Reaction Name: Viral inhibitor of caspase-8 activation (UL36) binds caspase-8 See in Reactome R-HSA-622420 ( R-HSA-168638 ) R-HSA-622420 Reaction Name: NOD1 induced apoptosis is mediated by RIP2 and CARD8 See in Reactome R-HSA-73945 ( R-HSA-140534; R-HSA-69416 ) R-HSA-73945 Reaction Name: FAS-mediated dimerization of procaspase-8 See in Reactome R-HSA-75146 ( R-HSA-75158 ) R-HSA-75146 Reaction Name: TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 See in Reactome R-HSA-75240 ( R-HSA-5357786 ) R-HSA-75240 Reaction Name: TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8 See in Reactome R-HSA-83586 ( R-HSA-75157 ) R-HSA-83586 Reaction Name: FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 See in Reactome R-HSA-9013889 ( R-HSA-9013957 ) R-HSA-9013889 Reaction Name: TLR3-induced ripoptosome assembly See in Reactome R-HSA-9013895 ( R-HSA-9013957 ) R-HSA-9013895 Reaction Name: Caspase-8 processing within TLR3 complex See in Reactome R-HSA-933523 ( R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933526 ( R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933532 ( R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933539 ( R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-9686930 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9686930 Reaction Name: RIPK3 is cleaved by CASP8 See in Reactome R-HSA-9687458 ( R-HSA-5213460; R-HSA-9686347 ) R-HSA-9687458 Reaction Name: HSV1 RIR1 binds CASP8 See in Reactome R-HSA-9697747 ( R-HSA-5357905 ) R-HSA-9697747 Reaction Name: Caspase-8 and FLIP(L) processing at TNFR signaling complex See in Reactome R-HSA-9697750 ( R-HSA-5357905 ) R-HSA-9697750 Reaction Name: RIPK1 is cleaved by CASP8:FLIP(L) See in Reactome