DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-5654219)

Number of enzymes:	2
Number of disease:	17
Number of reactomes:	15
Number of reactions:	38

Search results (Reactome ID: R-HSA-5654219)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005486	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0007400	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0007794	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0007844	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0008150	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0008428	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0008603	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0013074	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0014196	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0016355	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0016692	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0017219	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0019659	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0019756	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0060715	KL	Q9UEF7	3.2.1.31	R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0100251	KL	Q9UEF7	3.2.1.31	R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0100252	KL	Q9UEF7	3.2.1.31	R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome