DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-5649702)

Number of enzymes:	2
Number of disease:	5
Number of reactomes:	6
Number of reactions:	11

Search results (Reactome ID: R-HSA-5649702)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007763	OGG1	O15527	4.2.99.18 3.2.2.-	R-HSA-110357 R-HSA-110357 Reactome Name: Displacement of DNA glycosylase by APEX1 See in Reactome R-HSA-110330 R-HSA-110330 Reactome Name: Recognition and association of DNA glycosylase with site containing an affected purine See in Reactome R-HSA-110331 R-HSA-110331 Reactome Name: Cleavage of the damaged purine See in Reactome R-HSA-110329 R-HSA-110329 Reactome Name: Cleavage of the damaged pyrimidine See in Reactome R-HSA-110328 R-HSA-110328 Reactome Name: Recognition and association of DNA glycosylase with site containing an affected pyrimidine See in Reactome R-HSA-5649702 R-HSA-5649702 Reactome Name: APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway See in Reactome	R-HSA-73927 R-HSA-73927 Reactome Name: Depurination See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-73928 R-HSA-73928 Reactome Name: Depyrimidination See in Reactome R-HSA-73929 R-HSA-73929 Reactome Name: Base-Excision Repair, AP Site Formation See in Reactome	DNA Repair	R-HSA-110235 ( R-HSA-110330 ) R-HSA-110235 Reaction Name: OGG1 glycosylase mediated recognition and binding of an 8-oxoguanine opposite to a cytosine See in Reactome R-HSA-110236 ( R-HSA-110328 ) R-HSA-110236 Reaction Name: OGG1 glycosylase mediated recognition and binding of a formamidopyrimidine (FapyG) See in Reactome R-HSA-110243 ( R-HSA-110331 ) R-HSA-110243 Reaction Name: Excision of 8-oxoguanine by OGG1 glycosylase See in Reactome R-HSA-110244 ( R-HSA-110329 ) R-HSA-110244 Reaction Name: Excision of FapyG by OGG1 glycosylase See in Reactome R-HSA-110354 ( R-HSA-110357 ) R-HSA-110354 Reaction Name: Displacement of OGG1 glycosylase by APEX1 at the AP site See in Reactome R-HSA-5649701 ( R-HSA-5649702 ) R-HSA-5649701 Reaction Name: NEIL1,NEIL2 displace OGG1 from AP-dsDNA See in Reactome
MONDO:0011570	PNKP	Q96T60	3.1.3.32 2.7.1.78	R-HSA-5649702 R-HSA-5649702 Reactome Name: APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway See in Reactome	R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome	DNA Repair	R-HSA-5649705 ( R-HSA-5649702 ) R-HSA-5649705 Reaction Name: PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) See in Reactome R-HSA-5649723 ( R-HSA-5649702 ) R-HSA-5649723 Reaction Name: POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution See in Reactome R-HSA-5649724 ( R-HSA-5649702 ) R-HSA-5649724 Reaction Name: LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site See in Reactome R-HSA-5649726 ( R-HSA-5649702 ) R-HSA-5649726 Reaction Name: LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA See in Reactome R-HSA-5649734 ( R-HSA-5649702 ) R-HSA-5649734 Reaction Name: LIG3 ligates NEIL1,NEIL2-generated single strand break See in Reactome
MONDO:0013254	PNKP	Q96T60	3.1.3.32 2.7.1.78	R-HSA-5649702 R-HSA-5649702 Reactome Name: APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway See in Reactome	R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome	DNA Repair	R-HSA-5649705 ( R-HSA-5649702 ) R-HSA-5649705 Reaction Name: PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) See in Reactome R-HSA-5649723 ( R-HSA-5649702 ) R-HSA-5649723 Reaction Name: POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution See in Reactome R-HSA-5649724 ( R-HSA-5649702 ) R-HSA-5649724 Reaction Name: LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site See in Reactome R-HSA-5649726 ( R-HSA-5649702 ) R-HSA-5649726 Reaction Name: LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA See in Reactome R-HSA-5649734 ( R-HSA-5649702 ) R-HSA-5649734 Reaction Name: LIG3 ligates NEIL1,NEIL2-generated single strand break See in Reactome
MONDO:0013389	PNKP	Q96T60	3.1.3.32 2.7.1.78	R-HSA-5649702 R-HSA-5649702 Reactome Name: APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway See in Reactome	R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome	DNA Repair	R-HSA-5649705 ( R-HSA-5649702 ) R-HSA-5649705 Reaction Name: PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) See in Reactome R-HSA-5649723 ( R-HSA-5649702 ) R-HSA-5649723 Reaction Name: POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution See in Reactome R-HSA-5649724 ( R-HSA-5649702 ) R-HSA-5649724 Reaction Name: LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site See in Reactome R-HSA-5649726 ( R-HSA-5649702 ) R-HSA-5649726 Reaction Name: LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA See in Reactome R-HSA-5649734 ( R-HSA-5649702 ) R-HSA-5649734 Reaction Name: LIG3 ligates NEIL1,NEIL2-generated single strand break See in Reactome
MONDO:0014557	PNKP	Q96T60	3.1.3.32 2.7.1.78	R-HSA-5649702 R-HSA-5649702 Reactome Name: APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway See in Reactome	R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome	DNA Repair	R-HSA-5649705 ( R-HSA-5649702 ) R-HSA-5649705 Reaction Name: PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) See in Reactome R-HSA-5649723 ( R-HSA-5649702 ) R-HSA-5649723 Reaction Name: POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution See in Reactome R-HSA-5649724 ( R-HSA-5649702 ) R-HSA-5649724 Reaction Name: LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site See in Reactome R-HSA-5649726 ( R-HSA-5649702 ) R-HSA-5649726 Reaction Name: LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA See in Reactome R-HSA-5649734 ( R-HSA-5649702 ) R-HSA-5649734 Reaction Name: LIG3 ligates NEIL1,NEIL2-generated single strand break See in Reactome