DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-5625740)

Number of enzymes:	4
Number of disease:	16
Number of reactomes:	73
Number of reactions:	186

Search results (Reactome ID: R-HSA-5625740)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0002529	RAC1	P63000	3.6.5.2	R-HSA-376172 R-HSA-376172 Reactome Name: DSCAM interactions See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-9619229 R-HSA-9619229 Reactome Name: Activation of RAC1 downstream of NMDARs See in Reactome R-HSA-428540 R-HSA-428540 Reactome Name: Activation of RAC1 See in Reactome R-HSA-428543 R-HSA-428543 Reactome Name: Inactivation of CDC42 and RAC1 See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-399954 R-HSA-399954 Reactome Name: Sema3A PAK dependent Axon repulsion See in Reactome R-HSA-9032845 R-HSA-9032845 Reactome Name: Activated NTRK2 signals through CDK5 See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-193648 R-HSA-193648 Reactome Name: NRAGE signals death through JNK See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-9032759 R-HSA-9032759 Reactome Name: NTRK2 activates RAC1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-389359 R-HSA-389359 Reactome Name: CD28 dependent Vav1 pathway See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome R-HSA-399955 R-HSA-399955 Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion See in Reactome R-HSA-5626467 R-HSA-5626467 Reactome Name: RHO GTPases activate IQGAPs See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Developmental Biology Neuronal System Vesicle-mediated transport Hemostasis Signal Transduction	R-HSA-1011598 ( R-HSA-983231 ) R-HSA-1011598 Reaction Name: DOCKs bind to RhoGEFs See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1433415 ( R-HSA-1433557 ) R-HSA-1433415 Reaction Name: Activation of RAC1 See in Reactome R-HSA-2029451 ( R-HSA-2029482 ) R-HSA-2029451 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2029454 ( R-HSA-2029482 ) R-HSA-2029454 Reaction Name: Autophosphorylation of PAK1 See in Reactome R-HSA-2029456 ( R-HSA-2029482; R-HSA-5627123 ) R-HSA-2029456 Reaction Name: RAC1 and CDC42 activate PAK1 See in Reactome R-HSA-2029465 ( R-HSA-2029482; R-HSA-4420097; R-HSA-5663213 ) R-HSA-2029465 Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) See in Reactome R-HSA-2029466 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029466 Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin See in Reactome R-HSA-2029467 ( R-HSA-2029482 ) R-HSA-2029467 Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO See in Reactome R-HSA-2029469 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029469 Reaction Name: p-ERK phosphorylates WAVEs and ABI See in Reactome R-HSA-205039 ( R-HSA-193648 ) R-HSA-205039 Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor See in Reactome R-HSA-205136 ( R-HSA-193648 ) R-HSA-205136 Reaction Name: GTP-bound RAC contributes to JNK activation See in Reactome R-HSA-2130194 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2130194 Reaction Name: ABL phosphorylates WAVEs See in Reactome R-HSA-2197690 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2197690 Reaction Name: Detachment of WASP/WAVE See in Reactome R-HSA-2316352 ( R-HSA-1445148 ) R-HSA-2316352 Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424476 ( R-HSA-2424491 ) R-HSA-2424476 Reaction Name: Activation of RAC1 by VAV2/3 See in Reactome R-HSA-2730840 ( R-HSA-2871796 ) R-HSA-2730840 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2730856 ( R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730889 ( R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-376123 ( R-HSA-376172 ) R-HSA-376123 Reaction Name: DSCAM associates with Rac1-GTP:pPAK1 See in Reactome R-HSA-3858475 ( R-HSA-4086400 ) R-HSA-3858475 Reaction Name: ppDVL recruits RAC See in Reactome R-HSA-389348 ( R-HSA-389359 ) R-HSA-389348 Reaction Name: Activation of Rac1 by pVav1 See in Reactome R-HSA-389788 ( R-HSA-389359; R-HSA-5687128 ) R-HSA-389788 Reaction Name: Activation of PAKs by RAC1 and CDC42 See in Reactome R-HSA-3928612 ( R-HSA-3928662 ) R-HSA-3928612 Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928619 ( R-HSA-3928662 ) R-HSA-3928619 Reaction Name: PAK1 binds RAC1:GTP See in Reactome R-HSA-3928620 ( R-HSA-3928662 ) R-HSA-3928620 Reaction Name: PAK1 autophosphorylates See in Reactome R-HSA-3928625 ( R-HSA-3928664 ) R-HSA-3928625 Reaction Name: PAKs autophosphorylate See in Reactome R-HSA-3928628 ( R-HSA-3928665 ) R-HSA-3928628 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928633 ( R-HSA-3928664 ) R-HSA-3928633 Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it See in Reactome R-HSA-3928640 ( R-HSA-3928664 ) R-HSA-3928640 Reaction Name: PAKs phosphorylate MLC See in Reactome R-HSA-3928641 ( R-HSA-3928664 ) R-HSA-3928641 Reaction Name: PAK binds RAC and bPIX See in Reactome R-HSA-3928642 ( R-HSA-3928665 ) R-HSA-3928642 Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-399928 ( R-HSA-399955 ) R-HSA-399928 Reaction Name: Recruitment of Rnd1 to Plexin A See in Reactome R-HSA-399930 ( R-HSA-399954 ) R-HSA-399930 Reaction Name: Activation of PAK by Rac1 See in Reactome R-HSA-399935 ( R-HSA-399955 ) R-HSA-399935 Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity See in Reactome R-HSA-399938 ( R-HSA-399955 ) R-HSA-399938 Reaction Name: Activation of Rac1 by FARP2 See in Reactome R-HSA-399939 ( R-HSA-399954 ) R-HSA-399939 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-399941 ( R-HSA-399955 ) R-HSA-399941 Reaction Name: Rac1 binds PlexinA See in Reactome R-HSA-399952 ( R-HSA-399954 ) R-HSA-399952 Reaction Name: Phosphorylation of LIMK-1 by PAK See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-4093336 ( R-HSA-3928662 ) R-HSA-4093336 Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-418856 ( R-HSA-418885 ) R-HSA-418856 Reaction Name: Activation of Rac1 See in Reactome R-HSA-418865 ( R-HSA-418885 ) R-HSA-418865 Reaction Name: Recruitment of ABLIM to the plasma membrane See in Reactome R-HSA-428522 ( R-HSA-428543 ) R-HSA-428522 Reaction Name: Inactivation of RAC1 See in Reactome R-HSA-428535 ( R-HSA-428540 ) R-HSA-428535 Reaction Name: Activation of RAC1 by SOS See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442592 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-442592 Reaction Name: WASPs or WAVEs activate the ARP2/3 complex See in Reactome R-HSA-445064 ( R-HSA-445144 ) R-HSA-445064 Reaction Name: Activation of Rac1 by VAV2 See in Reactome R-HSA-445072 ( R-HSA-445144 ) R-HSA-445072 Reaction Name: Interaction of PAK1 with Rac1-GTP See in Reactome R-HSA-451347 ( R-HSA-376172 ) R-HSA-451347 Reaction Name: Activation of JNK by DSCAM See in Reactome R-HSA-451366 ( R-HSA-376172 ) R-HSA-451366 Reaction Name: Activation of p38MAPK by DSCAM See in Reactome R-HSA-5218827 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218827 Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1 See in Reactome R-HSA-5218839 ( R-HSA-4420097 ) R-HSA-5218839 Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1 See in Reactome R-HSA-5218841 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218841 Reaction Name: NADPH oxidase 2 generates superoxide from oxygen See in Reactome R-HSA-5218850 ( R-HSA-4420097 ) R-HSA-5218850 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-5357445 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357445 Reaction Name: PAK1-3 dimer disassociates See in Reactome R-HSA-5357472 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357472 Reaction Name: PAK1-3 autophosphorylates See in Reactome R-HSA-5357483 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357483 Reaction Name: RAC1 binds PAK1-3 See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5626469 ( R-HSA-5626467 ) R-HSA-5626469 Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs See in Reactome R-HSA-5626507 ( R-HSA-5626467 ) R-HSA-5626507 Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin See in Reactome R-HSA-5626549 ( R-HSA-5626467 ) R-HSA-5626549 Reaction Name: IQGAPs bind CALM1 See in Reactome R-HSA-5627775 ( R-HSA-5627123; R-HSA-5687128 ) R-HSA-5627775 Reaction Name: Autophosphorylation of PAK1,2,3 See in Reactome R-HSA-5663232 ( R-HSA-5663220 ) R-HSA-5663232 Reaction Name: FMNL1 binds RAC1:GTP See in Reactome R-HSA-5665659 ( R-HSA-5663220 ) R-HSA-5665659 Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin See in Reactome R-HSA-5665802 ( R-HSA-5663220 ) R-HSA-5665802 Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin See in Reactome R-HSA-5665809 ( R-HSA-5663220 ) R-HSA-5665809 Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments See in Reactome R-HSA-5668714 ( R-HSA-5668599 ) R-HSA-5668714 Reaction Name: RAC1:GTP binds NOX1 complex See in Reactome R-HSA-5668718 ( R-HSA-5668599 ) R-HSA-5668718 Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668731 ( R-HSA-5668599 ) R-HSA-5668731 Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668735 ( R-HSA-5668599 ) R-HSA-5668735 Reaction Name: RAC1:GTP binds NOX3 complex See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5672304 ( R-HSA-5626467 ) R-HSA-5672304 Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 See in Reactome R-HSA-5672329 ( R-HSA-5626467 ) R-HSA-5672329 Reaction Name: IQGAP1 binds CLIP1 and microtubules See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8848618 ( R-HSA-8849471 ) R-HSA-8848618 Reaction Name: Activation of RAC1 by the PXN:CRK complex See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8951586 ( R-HSA-4420097 ) R-HSA-8951586 Reaction Name: p-VAV family:PIP3 binds RAC1:GDP See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981926 ( R-HSA-5627123 ) R-HSA-8981926 Reaction Name: RAC1 and CDC42 activate PAK3 See in Reactome R-HSA-8981931 ( R-HSA-5627123 ) R-HSA-8981931 Reaction Name: RAC1 and CDC42 activate PAK2 See in Reactome R-HSA-9013143 ( R-HSA-9013149 ) R-HSA-9013143 Reaction Name: RAC1 GEFs activate RAC1 See in Reactome R-HSA-9013144 ( R-HSA-9013149 ) R-HSA-9013144 Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9013147 ( R-HSA-9013149 ) R-HSA-9013147 Reaction Name: RAC1 GDIs block activation of RAC1 See in Reactome R-HSA-9032798 ( R-HSA-9032759 ) R-HSA-9032798 Reaction Name: DOCK3 activates RAC1 See in Reactome R-HSA-9033292 ( R-HSA-9032845 ) R-HSA-9033292 Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1 See in Reactome R-HSA-9619803 ( R-HSA-9619229 ) R-HSA-9619803 Reaction Name: p-S516-ARHGEF7 activates RAC1 See in Reactome R-HSA-9691168 ( R-HSA-9013149 ) R-HSA-9691168 Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane See in Reactome R-HSA-9691174 ( R-HSA-9013149 ) R-HSA-9691174 Reaction Name: RAC1 binds effectors at the ER membrane See in Reactome
MONDO:0005012	RAC1	P63000	3.6.5.2	R-HSA-376172 R-HSA-376172 Reactome Name: DSCAM interactions See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-9619229 R-HSA-9619229 Reactome Name: Activation of RAC1 downstream of NMDARs See in Reactome R-HSA-428540 R-HSA-428540 Reactome Name: Activation of RAC1 See in Reactome R-HSA-428543 R-HSA-428543 Reactome Name: Inactivation of CDC42 and RAC1 See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-399954 R-HSA-399954 Reactome Name: Sema3A PAK dependent Axon repulsion See in Reactome R-HSA-9032845 R-HSA-9032845 Reactome Name: Activated NTRK2 signals through CDK5 See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-193648 R-HSA-193648 Reactome Name: NRAGE signals death through JNK See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-9032759 R-HSA-9032759 Reactome Name: NTRK2 activates RAC1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-389359 R-HSA-389359 Reactome Name: CD28 dependent Vav1 pathway See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome R-HSA-399955 R-HSA-399955 Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion See in Reactome R-HSA-5626467 R-HSA-5626467 Reactome Name: RHO GTPases activate IQGAPs See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Developmental Biology Neuronal System Vesicle-mediated transport Hemostasis Signal Transduction	R-HSA-1011598 ( R-HSA-983231 ) R-HSA-1011598 Reaction Name: DOCKs bind to RhoGEFs See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1433415 ( R-HSA-1433557 ) R-HSA-1433415 Reaction Name: Activation of RAC1 See in Reactome R-HSA-2029451 ( R-HSA-2029482 ) R-HSA-2029451 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2029454 ( R-HSA-2029482 ) R-HSA-2029454 Reaction Name: Autophosphorylation of PAK1 See in Reactome R-HSA-2029456 ( R-HSA-2029482; R-HSA-5627123 ) R-HSA-2029456 Reaction Name: RAC1 and CDC42 activate PAK1 See in Reactome R-HSA-2029465 ( R-HSA-2029482; R-HSA-4420097; R-HSA-5663213 ) R-HSA-2029465 Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) See in Reactome R-HSA-2029466 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029466 Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin See in Reactome R-HSA-2029467 ( R-HSA-2029482 ) R-HSA-2029467 Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO See in Reactome R-HSA-2029469 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029469 Reaction Name: p-ERK phosphorylates WAVEs and ABI See in Reactome R-HSA-205039 ( R-HSA-193648 ) R-HSA-205039 Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor See in Reactome R-HSA-205136 ( R-HSA-193648 ) R-HSA-205136 Reaction Name: GTP-bound RAC contributes to JNK activation See in Reactome R-HSA-2130194 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2130194 Reaction Name: ABL phosphorylates WAVEs See in Reactome R-HSA-2197690 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2197690 Reaction Name: Detachment of WASP/WAVE See in Reactome R-HSA-2316352 ( R-HSA-1445148 ) R-HSA-2316352 Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424476 ( R-HSA-2424491 ) R-HSA-2424476 Reaction Name: Activation of RAC1 by VAV2/3 See in Reactome R-HSA-2730840 ( R-HSA-2871796 ) R-HSA-2730840 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2730856 ( R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730889 ( R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-376123 ( R-HSA-376172 ) R-HSA-376123 Reaction Name: DSCAM associates with Rac1-GTP:pPAK1 See in Reactome R-HSA-3858475 ( R-HSA-4086400 ) R-HSA-3858475 Reaction Name: ppDVL recruits RAC See in Reactome R-HSA-389348 ( R-HSA-389359 ) R-HSA-389348 Reaction Name: Activation of Rac1 by pVav1 See in Reactome R-HSA-389788 ( R-HSA-389359; R-HSA-5687128 ) R-HSA-389788 Reaction Name: Activation of PAKs by RAC1 and CDC42 See in Reactome R-HSA-3928612 ( R-HSA-3928662 ) R-HSA-3928612 Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928619 ( R-HSA-3928662 ) R-HSA-3928619 Reaction Name: PAK1 binds RAC1:GTP See in Reactome R-HSA-3928620 ( R-HSA-3928662 ) R-HSA-3928620 Reaction Name: PAK1 autophosphorylates See in Reactome R-HSA-3928625 ( R-HSA-3928664 ) R-HSA-3928625 Reaction Name: PAKs autophosphorylate See in Reactome R-HSA-3928628 ( R-HSA-3928665 ) R-HSA-3928628 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928633 ( R-HSA-3928664 ) R-HSA-3928633 Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it See in Reactome R-HSA-3928640 ( R-HSA-3928664 ) R-HSA-3928640 Reaction Name: PAKs phosphorylate MLC See in Reactome R-HSA-3928641 ( R-HSA-3928664 ) R-HSA-3928641 Reaction Name: PAK binds RAC and bPIX See in Reactome R-HSA-3928642 ( R-HSA-3928665 ) R-HSA-3928642 Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-399928 ( R-HSA-399955 ) R-HSA-399928 Reaction Name: Recruitment of Rnd1 to Plexin A See in Reactome R-HSA-399930 ( R-HSA-399954 ) R-HSA-399930 Reaction Name: Activation of PAK by Rac1 See in Reactome R-HSA-399935 ( R-HSA-399955 ) R-HSA-399935 Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity See in Reactome R-HSA-399938 ( R-HSA-399955 ) R-HSA-399938 Reaction Name: Activation of Rac1 by FARP2 See in Reactome R-HSA-399939 ( R-HSA-399954 ) R-HSA-399939 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-399941 ( R-HSA-399955 ) R-HSA-399941 Reaction Name: Rac1 binds PlexinA See in Reactome R-HSA-399952 ( R-HSA-399954 ) R-HSA-399952 Reaction Name: Phosphorylation of LIMK-1 by PAK See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-4093336 ( R-HSA-3928662 ) R-HSA-4093336 Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-418856 ( R-HSA-418885 ) R-HSA-418856 Reaction Name: Activation of Rac1 See in Reactome R-HSA-418865 ( R-HSA-418885 ) R-HSA-418865 Reaction Name: Recruitment of ABLIM to the plasma membrane See in Reactome R-HSA-428522 ( R-HSA-428543 ) R-HSA-428522 Reaction Name: Inactivation of RAC1 See in Reactome R-HSA-428535 ( R-HSA-428540 ) R-HSA-428535 Reaction Name: Activation of RAC1 by SOS See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442592 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-442592 Reaction Name: WASPs or WAVEs activate the ARP2/3 complex See in Reactome R-HSA-445064 ( R-HSA-445144 ) R-HSA-445064 Reaction Name: Activation of Rac1 by VAV2 See in Reactome R-HSA-445072 ( R-HSA-445144 ) R-HSA-445072 Reaction Name: Interaction of PAK1 with Rac1-GTP See in Reactome R-HSA-451347 ( R-HSA-376172 ) R-HSA-451347 Reaction Name: Activation of JNK by DSCAM See in Reactome R-HSA-451366 ( R-HSA-376172 ) R-HSA-451366 Reaction Name: Activation of p38MAPK by DSCAM See in Reactome R-HSA-5218827 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218827 Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1 See in Reactome R-HSA-5218839 ( R-HSA-4420097 ) R-HSA-5218839 Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1 See in Reactome R-HSA-5218841 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218841 Reaction Name: NADPH oxidase 2 generates superoxide from oxygen See in Reactome R-HSA-5218850 ( R-HSA-4420097 ) R-HSA-5218850 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-5357445 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357445 Reaction Name: PAK1-3 dimer disassociates See in Reactome R-HSA-5357472 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357472 Reaction Name: PAK1-3 autophosphorylates See in Reactome R-HSA-5357483 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357483 Reaction Name: RAC1 binds PAK1-3 See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5626469 ( R-HSA-5626467 ) R-HSA-5626469 Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs See in Reactome R-HSA-5626507 ( R-HSA-5626467 ) R-HSA-5626507 Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin See in Reactome R-HSA-5626549 ( R-HSA-5626467 ) R-HSA-5626549 Reaction Name: IQGAPs bind CALM1 See in Reactome R-HSA-5627775 ( R-HSA-5627123; R-HSA-5687128 ) R-HSA-5627775 Reaction Name: Autophosphorylation of PAK1,2,3 See in Reactome R-HSA-5663232 ( R-HSA-5663220 ) R-HSA-5663232 Reaction Name: FMNL1 binds RAC1:GTP See in Reactome R-HSA-5665659 ( R-HSA-5663220 ) R-HSA-5665659 Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin See in Reactome R-HSA-5665802 ( R-HSA-5663220 ) R-HSA-5665802 Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin See in Reactome R-HSA-5665809 ( R-HSA-5663220 ) R-HSA-5665809 Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments See in Reactome R-HSA-5668714 ( R-HSA-5668599 ) R-HSA-5668714 Reaction Name: RAC1:GTP binds NOX1 complex See in Reactome R-HSA-5668718 ( R-HSA-5668599 ) R-HSA-5668718 Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668731 ( R-HSA-5668599 ) R-HSA-5668731 Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668735 ( R-HSA-5668599 ) R-HSA-5668735 Reaction Name: RAC1:GTP binds NOX3 complex See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5672304 ( R-HSA-5626467 ) R-HSA-5672304 Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 See in Reactome R-HSA-5672329 ( R-HSA-5626467 ) R-HSA-5672329 Reaction Name: IQGAP1 binds CLIP1 and microtubules See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8848618 ( R-HSA-8849471 ) R-HSA-8848618 Reaction Name: Activation of RAC1 by the PXN:CRK complex See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8951586 ( R-HSA-4420097 ) R-HSA-8951586 Reaction Name: p-VAV family:PIP3 binds RAC1:GDP See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981926 ( R-HSA-5627123 ) R-HSA-8981926 Reaction Name: RAC1 and CDC42 activate PAK3 See in Reactome R-HSA-8981931 ( R-HSA-5627123 ) R-HSA-8981931 Reaction Name: RAC1 and CDC42 activate PAK2 See in Reactome R-HSA-9013143 ( R-HSA-9013149 ) R-HSA-9013143 Reaction Name: RAC1 GEFs activate RAC1 See in Reactome R-HSA-9013144 ( R-HSA-9013149 ) R-HSA-9013144 Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9013147 ( R-HSA-9013149 ) R-HSA-9013147 Reaction Name: RAC1 GDIs block activation of RAC1 See in Reactome R-HSA-9032798 ( R-HSA-9032759 ) R-HSA-9032798 Reaction Name: DOCK3 activates RAC1 See in Reactome R-HSA-9033292 ( R-HSA-9032845 ) R-HSA-9033292 Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1 See in Reactome R-HSA-9619803 ( R-HSA-9619229 ) R-HSA-9619803 Reaction Name: p-S516-ARHGEF7 activates RAC1 See in Reactome R-HSA-9691168 ( R-HSA-9013149 ) R-HSA-9691168 Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane See in Reactome R-HSA-9691174 ( R-HSA-9013149 ) R-HSA-9691174 Reaction Name: RAC1 binds effectors at the ER membrane See in Reactome
MONDO:0005036	RHOA	P61586	3.6.5.2	R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-209563 R-HSA-209563 Reactome Name: Axonal growth stimulation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-193634 R-HSA-193634 Reactome Name: Axonal growth inhibition (RHOA activation) See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-5666185 R-HSA-5666185 Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-8985586 R-HSA-8985586 Reactome Name: SLIT2:ROBO1 increases RHOA activity See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-193697 R-HSA-193697 Reactome Name: p75NTR regulates axonogenesis See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114544 ( R-HSA-416482 ) R-HSA-114544 Reaction Name: p115-RhoGEF activation of RHOA See in Reactome R-HSA-193646 ( R-HSA-209563 ) R-HSA-193646 Reaction Name: NGF binding to p75NTR inactivates RHOA See in Reactome R-HSA-193668 ( R-HSA-209563 ) R-HSA-193668 Reaction Name: p75NTR and RHOA-GDI interact See in Reactome R-HSA-193696 ( R-HSA-193634 ) R-HSA-193696 Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA See in Reactome R-HSA-194518 ( R-HSA-193634 ) R-HSA-194518 Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth See in Reactome R-HSA-202692 ( R-HSA-198203; R-HSA-392451 ) R-HSA-202692 Reaction Name: PIP3 binds to RhoA and activates it See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-3858495 ( R-HSA-4086400; R-HSA-5663220 ) R-HSA-3858495 Reaction Name: DAAM1 recruits GTP-bound RHOA See in Reactome R-HSA-3928576 ( R-HSA-3928662 ) R-HSA-3928576 Reaction Name: RHOA:GTP binds ROCK, activating it See in Reactome R-HSA-3928577 ( R-HSA-3928662 ) R-HSA-3928577 Reaction Name: ROCK phosphorylates LIMK1,2 See in Reactome R-HSA-3928592 ( R-HSA-3928662 ) R-HSA-3928592 Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it See in Reactome R-HSA-3928616 ( R-HSA-3928663 ) R-HSA-3928616 Reaction Name: Activated ROCK phosphorylates MRLCs See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-3928651 ( R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416588 ( R-HSA-416572 ) R-HSA-416588 Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF See in Reactome R-HSA-419049 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-419049 Reaction Name: ROCK activation by RHO See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419087 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419087 Reaction Name: LIM kinase phosphorylation by ROCK See in Reactome R-HSA-419166 ( R-HSA-416482 ) R-HSA-419166 Reaction Name: GEFs activate RhoA,B,C See in Reactome R-HSA-419197 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419197 Reaction Name: Myosin regulatory light chain phosphorylation by ROCK See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5228992 ( R-HSA-4420097 ) R-HSA-5228992 Reaction Name: ROCK1,ROCK2 are activated See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5665982 ( R-HSA-5663220 ) R-HSA-5665982 Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 See in Reactome R-HSA-5665989 ( R-HSA-5663220 ) R-HSA-5665989 Reaction Name: DIAPH1 binds RHOA:GTP See in Reactome R-HSA-5666178 ( R-HSA-5666185 ) R-HSA-5666178 Reaction Name: RTKN binds RHOA, RHOC or RHOB See in Reactome R-HSA-5666197 ( R-HSA-5666185 ) R-HSA-5666197 Reaction Name: RHOA:GTP:RTKN binds LIN7B See in Reactome R-HSA-5666216 ( R-HSA-5666185 ) R-HSA-5666216 Reaction Name: RHOA:GTP:RTKN binds TAX1BP3 See in Reactome R-HSA-5667008 ( R-HSA-5666185 ) R-HSA-5667008 Reaction Name: RHOA:GTP binds RHPN1 or RHPN2 See in Reactome R-HSA-5667052 ( R-HSA-5666185 ) R-HSA-5667052 Reaction Name: ROPN1 binds RHOA:GTP:RHPN1 See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5690843 ( R-HSA-5689896 ) R-HSA-5690843 Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA See in Reactome R-HSA-6785648 ( R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8849082 ( R-HSA-8849471 ) R-HSA-8849082 Reaction Name: ARHGAP35 stimulates RHOA GTPase activity See in Reactome R-HSA-8849085 ( R-HSA-8849471 ) R-HSA-8849085 Reaction Name: ARHGAP35 binds RHOA:GTP See in Reactome R-HSA-8980691 ( R-HSA-8980692 ) R-HSA-8980691 Reaction Name: RHOA GEFs activate RHOA See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981637 ( R-HSA-8980692 ) R-HSA-8981637 Reaction Name: RHOA GAPs stimulate RHOA GTPase activity See in Reactome R-HSA-8985594 ( R-HSA-8985586 ) R-HSA-8985594 Reaction Name: MYO9B inactivates RHOA See in Reactome R-HSA-9012761 ( R-HSA-193634 ) R-HSA-9012761 Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI See in Reactome R-HSA-9012835 ( R-HSA-8980692 ) R-HSA-9012835 Reaction Name: GDIs block activation of RHOA See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013006 ( R-HSA-8980692 ) R-HSA-9013006 Reaction Name: RHOA:GTP translocates to the ER membrane See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome
MONDO:0005061	RHOA	P61586	3.6.5.2	R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-209563 R-HSA-209563 Reactome Name: Axonal growth stimulation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-193634 R-HSA-193634 Reactome Name: Axonal growth inhibition (RHOA activation) See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-5666185 R-HSA-5666185 Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-8985586 R-HSA-8985586 Reactome Name: SLIT2:ROBO1 increases RHOA activity See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-193697 R-HSA-193697 Reactome Name: p75NTR regulates axonogenesis See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114544 ( R-HSA-416482 ) R-HSA-114544 Reaction Name: p115-RhoGEF activation of RHOA See in Reactome R-HSA-193646 ( R-HSA-209563 ) R-HSA-193646 Reaction Name: NGF binding to p75NTR inactivates RHOA See in Reactome R-HSA-193668 ( R-HSA-209563 ) R-HSA-193668 Reaction Name: p75NTR and RHOA-GDI interact See in Reactome R-HSA-193696 ( R-HSA-193634 ) R-HSA-193696 Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA See in Reactome R-HSA-194518 ( R-HSA-193634 ) R-HSA-194518 Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth See in Reactome R-HSA-202692 ( R-HSA-198203; R-HSA-392451 ) R-HSA-202692 Reaction Name: PIP3 binds to RhoA and activates it See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-3858495 ( R-HSA-4086400; R-HSA-5663220 ) R-HSA-3858495 Reaction Name: DAAM1 recruits GTP-bound RHOA See in Reactome R-HSA-3928576 ( R-HSA-3928662 ) R-HSA-3928576 Reaction Name: RHOA:GTP binds ROCK, activating it See in Reactome R-HSA-3928577 ( R-HSA-3928662 ) R-HSA-3928577 Reaction Name: ROCK phosphorylates LIMK1,2 See in Reactome R-HSA-3928592 ( R-HSA-3928662 ) R-HSA-3928592 Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it See in Reactome R-HSA-3928616 ( R-HSA-3928663 ) R-HSA-3928616 Reaction Name: Activated ROCK phosphorylates MRLCs See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-3928651 ( R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416588 ( R-HSA-416572 ) R-HSA-416588 Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF See in Reactome R-HSA-419049 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-419049 Reaction Name: ROCK activation by RHO See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419087 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419087 Reaction Name: LIM kinase phosphorylation by ROCK See in Reactome R-HSA-419166 ( R-HSA-416482 ) R-HSA-419166 Reaction Name: GEFs activate RhoA,B,C See in Reactome R-HSA-419197 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419197 Reaction Name: Myosin regulatory light chain phosphorylation by ROCK See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5228992 ( R-HSA-4420097 ) R-HSA-5228992 Reaction Name: ROCK1,ROCK2 are activated See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5665982 ( R-HSA-5663220 ) R-HSA-5665982 Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 See in Reactome R-HSA-5665989 ( R-HSA-5663220 ) R-HSA-5665989 Reaction Name: DIAPH1 binds RHOA:GTP See in Reactome R-HSA-5666178 ( R-HSA-5666185 ) R-HSA-5666178 Reaction Name: RTKN binds RHOA, RHOC or RHOB See in Reactome R-HSA-5666197 ( R-HSA-5666185 ) R-HSA-5666197 Reaction Name: RHOA:GTP:RTKN binds LIN7B See in Reactome R-HSA-5666216 ( R-HSA-5666185 ) R-HSA-5666216 Reaction Name: RHOA:GTP:RTKN binds TAX1BP3 See in Reactome R-HSA-5667008 ( R-HSA-5666185 ) R-HSA-5667008 Reaction Name: RHOA:GTP binds RHPN1 or RHPN2 See in Reactome R-HSA-5667052 ( R-HSA-5666185 ) R-HSA-5667052 Reaction Name: ROPN1 binds RHOA:GTP:RHPN1 See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5690843 ( R-HSA-5689896 ) R-HSA-5690843 Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA See in Reactome R-HSA-6785648 ( R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8849082 ( R-HSA-8849471 ) R-HSA-8849082 Reaction Name: ARHGAP35 stimulates RHOA GTPase activity See in Reactome R-HSA-8849085 ( R-HSA-8849471 ) R-HSA-8849085 Reaction Name: ARHGAP35 binds RHOA:GTP See in Reactome R-HSA-8980691 ( R-HSA-8980692 ) R-HSA-8980691 Reaction Name: RHOA GEFs activate RHOA See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981637 ( R-HSA-8980692 ) R-HSA-8981637 Reaction Name: RHOA GAPs stimulate RHOA GTPase activity See in Reactome R-HSA-8985594 ( R-HSA-8985586 ) R-HSA-8985594 Reaction Name: MYO9B inactivates RHOA See in Reactome R-HSA-9012761 ( R-HSA-193634 ) R-HSA-9012761 Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI See in Reactome R-HSA-9012835 ( R-HSA-8980692 ) R-HSA-9012835 Reaction Name: GDIs block activation of RHOA See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013006 ( R-HSA-8980692 ) R-HSA-9013006 Reaction Name: RHOA:GTP translocates to the ER membrane See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome
MONDO:0005335	RHOA	P61586	3.6.5.2	R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-209563 R-HSA-209563 Reactome Name: Axonal growth stimulation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-193634 R-HSA-193634 Reactome Name: Axonal growth inhibition (RHOA activation) See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-5666185 R-HSA-5666185 Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-8985586 R-HSA-8985586 Reactome Name: SLIT2:ROBO1 increases RHOA activity See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-193697 R-HSA-193697 Reactome Name: p75NTR regulates axonogenesis See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114544 ( R-HSA-416482 ) R-HSA-114544 Reaction Name: p115-RhoGEF activation of RHOA See in Reactome R-HSA-193646 ( R-HSA-209563 ) R-HSA-193646 Reaction Name: NGF binding to p75NTR inactivates RHOA See in Reactome R-HSA-193668 ( R-HSA-209563 ) R-HSA-193668 Reaction Name: p75NTR and RHOA-GDI interact See in Reactome R-HSA-193696 ( R-HSA-193634 ) R-HSA-193696 Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA See in Reactome R-HSA-194518 ( R-HSA-193634 ) R-HSA-194518 Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth See in Reactome R-HSA-202692 ( R-HSA-198203; R-HSA-392451 ) R-HSA-202692 Reaction Name: PIP3 binds to RhoA and activates it See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-3858495 ( R-HSA-4086400; R-HSA-5663220 ) R-HSA-3858495 Reaction Name: DAAM1 recruits GTP-bound RHOA See in Reactome R-HSA-3928576 ( R-HSA-3928662 ) R-HSA-3928576 Reaction Name: RHOA:GTP binds ROCK, activating it See in Reactome R-HSA-3928577 ( R-HSA-3928662 ) R-HSA-3928577 Reaction Name: ROCK phosphorylates LIMK1,2 See in Reactome R-HSA-3928592 ( R-HSA-3928662 ) R-HSA-3928592 Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it See in Reactome R-HSA-3928616 ( R-HSA-3928663 ) R-HSA-3928616 Reaction Name: Activated ROCK phosphorylates MRLCs See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-3928651 ( R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416588 ( R-HSA-416572 ) R-HSA-416588 Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF See in Reactome R-HSA-419049 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-419049 Reaction Name: ROCK activation by RHO See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419087 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419087 Reaction Name: LIM kinase phosphorylation by ROCK See in Reactome R-HSA-419166 ( R-HSA-416482 ) R-HSA-419166 Reaction Name: GEFs activate RhoA,B,C See in Reactome R-HSA-419197 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419197 Reaction Name: Myosin regulatory light chain phosphorylation by ROCK See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5228992 ( R-HSA-4420097 ) R-HSA-5228992 Reaction Name: ROCK1,ROCK2 are activated See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5665982 ( R-HSA-5663220 ) R-HSA-5665982 Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 See in Reactome R-HSA-5665989 ( R-HSA-5663220 ) R-HSA-5665989 Reaction Name: DIAPH1 binds RHOA:GTP See in Reactome R-HSA-5666178 ( R-HSA-5666185 ) R-HSA-5666178 Reaction Name: RTKN binds RHOA, RHOC or RHOB See in Reactome R-HSA-5666197 ( R-HSA-5666185 ) R-HSA-5666197 Reaction Name: RHOA:GTP:RTKN binds LIN7B See in Reactome R-HSA-5666216 ( R-HSA-5666185 ) R-HSA-5666216 Reaction Name: RHOA:GTP:RTKN binds TAX1BP3 See in Reactome R-HSA-5667008 ( R-HSA-5666185 ) R-HSA-5667008 Reaction Name: RHOA:GTP binds RHPN1 or RHPN2 See in Reactome R-HSA-5667052 ( R-HSA-5666185 ) R-HSA-5667052 Reaction Name: ROPN1 binds RHOA:GTP:RHPN1 See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5690843 ( R-HSA-5689896 ) R-HSA-5690843 Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA See in Reactome R-HSA-6785648 ( R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8849082 ( R-HSA-8849471 ) R-HSA-8849082 Reaction Name: ARHGAP35 stimulates RHOA GTPase activity See in Reactome R-HSA-8849085 ( R-HSA-8849471 ) R-HSA-8849085 Reaction Name: ARHGAP35 binds RHOA:GTP See in Reactome R-HSA-8980691 ( R-HSA-8980692 ) R-HSA-8980691 Reaction Name: RHOA GEFs activate RHOA See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981637 ( R-HSA-8980692 ) R-HSA-8981637 Reaction Name: RHOA GAPs stimulate RHOA GTPase activity See in Reactome R-HSA-8985594 ( R-HSA-8985586 ) R-HSA-8985594 Reaction Name: MYO9B inactivates RHOA See in Reactome R-HSA-9012761 ( R-HSA-193634 ) R-HSA-9012761 Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI See in Reactome R-HSA-9012835 ( R-HSA-8980692 ) R-HSA-9012835 Reaction Name: GDIs block activation of RHOA See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013006 ( R-HSA-8980692 ) R-HSA-9013006 Reaction Name: RHOA:GTP translocates to the ER membrane See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome
MONDO:0009072	PPP1CB	P62140	3.1.3.16 3.1.3.53	R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-2565942 R-HSA-2565942 Reactome Name: Regulation of PLK1 Activity at G2/M Transition See in Reactome R-HSA-163560 R-HSA-163560 Reactome Name: Triglyceride catabolism See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome	R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-8979227 R-HSA-8979227 Reactome Name: Triglyceride metabolism See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Circadian Clock Metabolism Signal Transduction Cell Cycle	R-HSA-163568 ( R-HSA-163560 ) R-HSA-163568 Reaction Name: phosphorylated perilipin + H2O -> perilipin + orthophosphate See in Reactome R-HSA-178178 ( R-HSA-2173788 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-3002811 ( R-HSA-2565942 ) R-HSA-3002811 Reaction Name: Myosin phosphatase dephosphorylates PLK1 See in Reactome R-HSA-400382 ( R-HSA-400253 ) R-HSA-400382 Reaction Name: CSNK1E,CSNK1D phosphorylate CRY and PER proteins See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419232 ( R-HSA-5625740; R-HSA-5627117; R-HSA-5627123 ) R-HSA-419232 Reaction Name: Myosin phosphatase dephosphorylates myosin regulatory light chain See in Reactome R-HSA-5668947 ( R-HSA-5627123 ) R-HSA-5668947 Reaction Name: PAK1 phosphorylates myosin phosphatase See in Reactome R-HSA-5668978 ( R-HSA-5627123 ) R-HSA-5668978 Reaction Name: MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex See in Reactome R-HSA-5671772 ( R-HSA-5625740 ) R-HSA-5671772 Reaction Name: p-T38-PPP1R14A binds MLCP See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome
MONDO:0010150	RHOA	P61586	3.6.5.2	R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-209563 R-HSA-209563 Reactome Name: Axonal growth stimulation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-193634 R-HSA-193634 Reactome Name: Axonal growth inhibition (RHOA activation) See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-5666185 R-HSA-5666185 Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-8985586 R-HSA-8985586 Reactome Name: SLIT2:ROBO1 increases RHOA activity See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-193697 R-HSA-193697 Reactome Name: p75NTR regulates axonogenesis See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114544 ( R-HSA-416482 ) R-HSA-114544 Reaction Name: p115-RhoGEF activation of RHOA See in Reactome R-HSA-193646 ( R-HSA-209563 ) R-HSA-193646 Reaction Name: NGF binding to p75NTR inactivates RHOA See in Reactome R-HSA-193668 ( R-HSA-209563 ) R-HSA-193668 Reaction Name: p75NTR and RHOA-GDI interact See in Reactome R-HSA-193696 ( R-HSA-193634 ) R-HSA-193696 Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA See in Reactome R-HSA-194518 ( R-HSA-193634 ) R-HSA-194518 Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth See in Reactome R-HSA-202692 ( R-HSA-198203; R-HSA-392451 ) R-HSA-202692 Reaction Name: PIP3 binds to RhoA and activates it See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-3858495 ( R-HSA-4086400; R-HSA-5663220 ) R-HSA-3858495 Reaction Name: DAAM1 recruits GTP-bound RHOA See in Reactome R-HSA-3928576 ( R-HSA-3928662 ) R-HSA-3928576 Reaction Name: RHOA:GTP binds ROCK, activating it See in Reactome R-HSA-3928577 ( R-HSA-3928662 ) R-HSA-3928577 Reaction Name: ROCK phosphorylates LIMK1,2 See in Reactome R-HSA-3928592 ( R-HSA-3928662 ) R-HSA-3928592 Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it See in Reactome R-HSA-3928616 ( R-HSA-3928663 ) R-HSA-3928616 Reaction Name: Activated ROCK phosphorylates MRLCs See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-3928651 ( R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416588 ( R-HSA-416572 ) R-HSA-416588 Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF See in Reactome R-HSA-419049 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-419049 Reaction Name: ROCK activation by RHO See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419087 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419087 Reaction Name: LIM kinase phosphorylation by ROCK See in Reactome R-HSA-419166 ( R-HSA-416482 ) R-HSA-419166 Reaction Name: GEFs activate RhoA,B,C See in Reactome R-HSA-419197 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419197 Reaction Name: Myosin regulatory light chain phosphorylation by ROCK See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5228992 ( R-HSA-4420097 ) R-HSA-5228992 Reaction Name: ROCK1,ROCK2 are activated See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5665982 ( R-HSA-5663220 ) R-HSA-5665982 Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 See in Reactome R-HSA-5665989 ( R-HSA-5663220 ) R-HSA-5665989 Reaction Name: DIAPH1 binds RHOA:GTP See in Reactome R-HSA-5666178 ( R-HSA-5666185 ) R-HSA-5666178 Reaction Name: RTKN binds RHOA, RHOC or RHOB See in Reactome R-HSA-5666197 ( R-HSA-5666185 ) R-HSA-5666197 Reaction Name: RHOA:GTP:RTKN binds LIN7B See in Reactome R-HSA-5666216 ( R-HSA-5666185 ) R-HSA-5666216 Reaction Name: RHOA:GTP:RTKN binds TAX1BP3 See in Reactome R-HSA-5667008 ( R-HSA-5666185 ) R-HSA-5667008 Reaction Name: RHOA:GTP binds RHPN1 or RHPN2 See in Reactome R-HSA-5667052 ( R-HSA-5666185 ) R-HSA-5667052 Reaction Name: ROPN1 binds RHOA:GTP:RHPN1 See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5690843 ( R-HSA-5689896 ) R-HSA-5690843 Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA See in Reactome R-HSA-6785648 ( R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8849082 ( R-HSA-8849471 ) R-HSA-8849082 Reaction Name: ARHGAP35 stimulates RHOA GTPase activity See in Reactome R-HSA-8849085 ( R-HSA-8849471 ) R-HSA-8849085 Reaction Name: ARHGAP35 binds RHOA:GTP See in Reactome R-HSA-8980691 ( R-HSA-8980692 ) R-HSA-8980691 Reaction Name: RHOA GEFs activate RHOA See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981637 ( R-HSA-8980692 ) R-HSA-8981637 Reaction Name: RHOA GAPs stimulate RHOA GTPase activity See in Reactome R-HSA-8985594 ( R-HSA-8985586 ) R-HSA-8985594 Reaction Name: MYO9B inactivates RHOA See in Reactome R-HSA-9012761 ( R-HSA-193634 ) R-HSA-9012761 Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI See in Reactome R-HSA-9012835 ( R-HSA-8980692 ) R-HSA-9012835 Reaction Name: GDIs block activation of RHOA See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013006 ( R-HSA-8980692 ) R-HSA-9013006 Reaction Name: RHOA:GTP translocates to the ER membrane See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome
MONDO:0010150	RAC1	P63000	3.6.5.2	R-HSA-376172 R-HSA-376172 Reactome Name: DSCAM interactions See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-9619229 R-HSA-9619229 Reactome Name: Activation of RAC1 downstream of NMDARs See in Reactome R-HSA-428540 R-HSA-428540 Reactome Name: Activation of RAC1 See in Reactome R-HSA-428543 R-HSA-428543 Reactome Name: Inactivation of CDC42 and RAC1 See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-399954 R-HSA-399954 Reactome Name: Sema3A PAK dependent Axon repulsion See in Reactome R-HSA-9032845 R-HSA-9032845 Reactome Name: Activated NTRK2 signals through CDK5 See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-193648 R-HSA-193648 Reactome Name: NRAGE signals death through JNK See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-9032759 R-HSA-9032759 Reactome Name: NTRK2 activates RAC1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-389359 R-HSA-389359 Reactome Name: CD28 dependent Vav1 pathway See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome R-HSA-399955 R-HSA-399955 Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion See in Reactome R-HSA-5626467 R-HSA-5626467 Reactome Name: RHO GTPases activate IQGAPs See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Developmental Biology Neuronal System Vesicle-mediated transport Hemostasis Signal Transduction	R-HSA-1011598 ( R-HSA-983231 ) R-HSA-1011598 Reaction Name: DOCKs bind to RhoGEFs See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1433415 ( R-HSA-1433557 ) R-HSA-1433415 Reaction Name: Activation of RAC1 See in Reactome R-HSA-2029451 ( R-HSA-2029482 ) R-HSA-2029451 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2029454 ( R-HSA-2029482 ) R-HSA-2029454 Reaction Name: Autophosphorylation of PAK1 See in Reactome R-HSA-2029456 ( R-HSA-2029482; R-HSA-5627123 ) R-HSA-2029456 Reaction Name: RAC1 and CDC42 activate PAK1 See in Reactome R-HSA-2029465 ( R-HSA-2029482; R-HSA-4420097; R-HSA-5663213 ) R-HSA-2029465 Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) See in Reactome R-HSA-2029466 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029466 Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin See in Reactome R-HSA-2029467 ( R-HSA-2029482 ) R-HSA-2029467 Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO See in Reactome R-HSA-2029469 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029469 Reaction Name: p-ERK phosphorylates WAVEs and ABI See in Reactome R-HSA-205039 ( R-HSA-193648 ) R-HSA-205039 Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor See in Reactome R-HSA-205136 ( R-HSA-193648 ) R-HSA-205136 Reaction Name: GTP-bound RAC contributes to JNK activation See in Reactome R-HSA-2130194 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2130194 Reaction Name: ABL phosphorylates WAVEs See in Reactome R-HSA-2197690 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2197690 Reaction Name: Detachment of WASP/WAVE See in Reactome R-HSA-2316352 ( R-HSA-1445148 ) R-HSA-2316352 Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424476 ( R-HSA-2424491 ) R-HSA-2424476 Reaction Name: Activation of RAC1 by VAV2/3 See in Reactome R-HSA-2730840 ( R-HSA-2871796 ) R-HSA-2730840 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2730856 ( R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730889 ( R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-376123 ( R-HSA-376172 ) R-HSA-376123 Reaction Name: DSCAM associates with Rac1-GTP:pPAK1 See in Reactome R-HSA-3858475 ( R-HSA-4086400 ) R-HSA-3858475 Reaction Name: ppDVL recruits RAC See in Reactome R-HSA-389348 ( R-HSA-389359 ) R-HSA-389348 Reaction Name: Activation of Rac1 by pVav1 See in Reactome R-HSA-389788 ( R-HSA-389359; R-HSA-5687128 ) R-HSA-389788 Reaction Name: Activation of PAKs by RAC1 and CDC42 See in Reactome R-HSA-3928612 ( R-HSA-3928662 ) R-HSA-3928612 Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928619 ( R-HSA-3928662 ) R-HSA-3928619 Reaction Name: PAK1 binds RAC1:GTP See in Reactome R-HSA-3928620 ( R-HSA-3928662 ) R-HSA-3928620 Reaction Name: PAK1 autophosphorylates See in Reactome R-HSA-3928625 ( R-HSA-3928664 ) R-HSA-3928625 Reaction Name: PAKs autophosphorylate See in Reactome R-HSA-3928628 ( R-HSA-3928665 ) R-HSA-3928628 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928633 ( R-HSA-3928664 ) R-HSA-3928633 Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it See in Reactome R-HSA-3928640 ( R-HSA-3928664 ) R-HSA-3928640 Reaction Name: PAKs phosphorylate MLC See in Reactome R-HSA-3928641 ( R-HSA-3928664 ) R-HSA-3928641 Reaction Name: PAK binds RAC and bPIX See in Reactome R-HSA-3928642 ( R-HSA-3928665 ) R-HSA-3928642 Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-399928 ( R-HSA-399955 ) R-HSA-399928 Reaction Name: Recruitment of Rnd1 to Plexin A See in Reactome R-HSA-399930 ( R-HSA-399954 ) R-HSA-399930 Reaction Name: Activation of PAK by Rac1 See in Reactome R-HSA-399935 ( R-HSA-399955 ) R-HSA-399935 Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity See in Reactome R-HSA-399938 ( R-HSA-399955 ) R-HSA-399938 Reaction Name: Activation of Rac1 by FARP2 See in Reactome R-HSA-399939 ( R-HSA-399954 ) R-HSA-399939 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-399941 ( R-HSA-399955 ) R-HSA-399941 Reaction Name: Rac1 binds PlexinA See in Reactome R-HSA-399952 ( R-HSA-399954 ) R-HSA-399952 Reaction Name: Phosphorylation of LIMK-1 by PAK See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-4093336 ( R-HSA-3928662 ) R-HSA-4093336 Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-418856 ( R-HSA-418885 ) R-HSA-418856 Reaction Name: Activation of Rac1 See in Reactome R-HSA-418865 ( R-HSA-418885 ) R-HSA-418865 Reaction Name: Recruitment of ABLIM to the plasma membrane See in Reactome R-HSA-428522 ( R-HSA-428543 ) R-HSA-428522 Reaction Name: Inactivation of RAC1 See in Reactome R-HSA-428535 ( R-HSA-428540 ) R-HSA-428535 Reaction Name: Activation of RAC1 by SOS See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442592 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-442592 Reaction Name: WASPs or WAVEs activate the ARP2/3 complex See in Reactome R-HSA-445064 ( R-HSA-445144 ) R-HSA-445064 Reaction Name: Activation of Rac1 by VAV2 See in Reactome R-HSA-445072 ( R-HSA-445144 ) R-HSA-445072 Reaction Name: Interaction of PAK1 with Rac1-GTP See in Reactome R-HSA-451347 ( R-HSA-376172 ) R-HSA-451347 Reaction Name: Activation of JNK by DSCAM See in Reactome R-HSA-451366 ( R-HSA-376172 ) R-HSA-451366 Reaction Name: Activation of p38MAPK by DSCAM See in Reactome R-HSA-5218827 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218827 Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1 See in Reactome R-HSA-5218839 ( R-HSA-4420097 ) R-HSA-5218839 Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1 See in Reactome R-HSA-5218841 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218841 Reaction Name: NADPH oxidase 2 generates superoxide from oxygen See in Reactome R-HSA-5218850 ( R-HSA-4420097 ) R-HSA-5218850 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-5357445 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357445 Reaction Name: PAK1-3 dimer disassociates See in Reactome R-HSA-5357472 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357472 Reaction Name: PAK1-3 autophosphorylates See in Reactome R-HSA-5357483 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357483 Reaction Name: RAC1 binds PAK1-3 See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5626469 ( R-HSA-5626467 ) R-HSA-5626469 Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs See in Reactome R-HSA-5626507 ( R-HSA-5626467 ) R-HSA-5626507 Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin See in Reactome R-HSA-5626549 ( R-HSA-5626467 ) R-HSA-5626549 Reaction Name: IQGAPs bind CALM1 See in Reactome R-HSA-5627775 ( R-HSA-5627123; R-HSA-5687128 ) R-HSA-5627775 Reaction Name: Autophosphorylation of PAK1,2,3 See in Reactome R-HSA-5663232 ( R-HSA-5663220 ) R-HSA-5663232 Reaction Name: FMNL1 binds RAC1:GTP See in Reactome R-HSA-5665659 ( R-HSA-5663220 ) R-HSA-5665659 Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin See in Reactome R-HSA-5665802 ( R-HSA-5663220 ) R-HSA-5665802 Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin See in Reactome R-HSA-5665809 ( R-HSA-5663220 ) R-HSA-5665809 Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments See in Reactome R-HSA-5668714 ( R-HSA-5668599 ) R-HSA-5668714 Reaction Name: RAC1:GTP binds NOX1 complex See in Reactome R-HSA-5668718 ( R-HSA-5668599 ) R-HSA-5668718 Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668731 ( R-HSA-5668599 ) R-HSA-5668731 Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668735 ( R-HSA-5668599 ) R-HSA-5668735 Reaction Name: RAC1:GTP binds NOX3 complex See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5672304 ( R-HSA-5626467 ) R-HSA-5672304 Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 See in Reactome R-HSA-5672329 ( R-HSA-5626467 ) R-HSA-5672329 Reaction Name: IQGAP1 binds CLIP1 and microtubules See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8848618 ( R-HSA-8849471 ) R-HSA-8848618 Reaction Name: Activation of RAC1 by the PXN:CRK complex See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8951586 ( R-HSA-4420097 ) R-HSA-8951586 Reaction Name: p-VAV family:PIP3 binds RAC1:GDP See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981926 ( R-HSA-5627123 ) R-HSA-8981926 Reaction Name: RAC1 and CDC42 activate PAK3 See in Reactome R-HSA-8981931 ( R-HSA-5627123 ) R-HSA-8981931 Reaction Name: RAC1 and CDC42 activate PAK2 See in Reactome R-HSA-9013143 ( R-HSA-9013149 ) R-HSA-9013143 Reaction Name: RAC1 GEFs activate RAC1 See in Reactome R-HSA-9013144 ( R-HSA-9013149 ) R-HSA-9013144 Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9013147 ( R-HSA-9013149 ) R-HSA-9013147 Reaction Name: RAC1 GDIs block activation of RAC1 See in Reactome R-HSA-9032798 ( R-HSA-9032759 ) R-HSA-9032798 Reaction Name: DOCK3 activates RAC1 See in Reactome R-HSA-9033292 ( R-HSA-9032845 ) R-HSA-9033292 Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1 See in Reactome R-HSA-9619803 ( R-HSA-9619229 ) R-HSA-9619803 Reaction Name: p-S516-ARHGEF7 activates RAC1 See in Reactome R-HSA-9691168 ( R-HSA-9013149 ) R-HSA-9691168 Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane See in Reactome R-HSA-9691174 ( R-HSA-9013149 ) R-HSA-9691174 Reaction Name: RAC1 binds effectors at the ER membrane See in Reactome
MONDO:0018908	RHOA	P61586	3.6.5.2	R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-209563 R-HSA-209563 Reactome Name: Axonal growth stimulation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-193634 R-HSA-193634 Reactome Name: Axonal growth inhibition (RHOA activation) See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-5666185 R-HSA-5666185 Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-8985586 R-HSA-8985586 Reactome Name: SLIT2:ROBO1 increases RHOA activity See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-193697 R-HSA-193697 Reactome Name: p75NTR regulates axonogenesis See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114544 ( R-HSA-416482 ) R-HSA-114544 Reaction Name: p115-RhoGEF activation of RHOA See in Reactome R-HSA-193646 ( R-HSA-209563 ) R-HSA-193646 Reaction Name: NGF binding to p75NTR inactivates RHOA See in Reactome R-HSA-193668 ( R-HSA-209563 ) R-HSA-193668 Reaction Name: p75NTR and RHOA-GDI interact See in Reactome R-HSA-193696 ( R-HSA-193634 ) R-HSA-193696 Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA See in Reactome R-HSA-194518 ( R-HSA-193634 ) R-HSA-194518 Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth See in Reactome R-HSA-202692 ( R-HSA-198203; R-HSA-392451 ) R-HSA-202692 Reaction Name: PIP3 binds to RhoA and activates it See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-3858495 ( R-HSA-4086400; R-HSA-5663220 ) R-HSA-3858495 Reaction Name: DAAM1 recruits GTP-bound RHOA See in Reactome R-HSA-3928576 ( R-HSA-3928662 ) R-HSA-3928576 Reaction Name: RHOA:GTP binds ROCK, activating it See in Reactome R-HSA-3928577 ( R-HSA-3928662 ) R-HSA-3928577 Reaction Name: ROCK phosphorylates LIMK1,2 See in Reactome R-HSA-3928592 ( R-HSA-3928662 ) R-HSA-3928592 Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it See in Reactome R-HSA-3928616 ( R-HSA-3928663 ) R-HSA-3928616 Reaction Name: Activated ROCK phosphorylates MRLCs See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-3928651 ( R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416588 ( R-HSA-416572 ) R-HSA-416588 Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF See in Reactome R-HSA-419049 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-419049 Reaction Name: ROCK activation by RHO See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419087 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419087 Reaction Name: LIM kinase phosphorylation by ROCK See in Reactome R-HSA-419166 ( R-HSA-416482 ) R-HSA-419166 Reaction Name: GEFs activate RhoA,B,C See in Reactome R-HSA-419197 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419197 Reaction Name: Myosin regulatory light chain phosphorylation by ROCK See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5228992 ( R-HSA-4420097 ) R-HSA-5228992 Reaction Name: ROCK1,ROCK2 are activated See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5665982 ( R-HSA-5663220 ) R-HSA-5665982 Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 See in Reactome R-HSA-5665989 ( R-HSA-5663220 ) R-HSA-5665989 Reaction Name: DIAPH1 binds RHOA:GTP See in Reactome R-HSA-5666178 ( R-HSA-5666185 ) R-HSA-5666178 Reaction Name: RTKN binds RHOA, RHOC or RHOB See in Reactome R-HSA-5666197 ( R-HSA-5666185 ) R-HSA-5666197 Reaction Name: RHOA:GTP:RTKN binds LIN7B See in Reactome R-HSA-5666216 ( R-HSA-5666185 ) R-HSA-5666216 Reaction Name: RHOA:GTP:RTKN binds TAX1BP3 See in Reactome R-HSA-5667008 ( R-HSA-5666185 ) R-HSA-5667008 Reaction Name: RHOA:GTP binds RHPN1 or RHPN2 See in Reactome R-HSA-5667052 ( R-HSA-5666185 ) R-HSA-5667052 Reaction Name: ROPN1 binds RHOA:GTP:RHPN1 See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5690843 ( R-HSA-5689896 ) R-HSA-5690843 Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA See in Reactome R-HSA-6785648 ( R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8849082 ( R-HSA-8849471 ) R-HSA-8849082 Reaction Name: ARHGAP35 stimulates RHOA GTPase activity See in Reactome R-HSA-8849085 ( R-HSA-8849471 ) R-HSA-8849085 Reaction Name: ARHGAP35 binds RHOA:GTP See in Reactome R-HSA-8980691 ( R-HSA-8980692 ) R-HSA-8980691 Reaction Name: RHOA GEFs activate RHOA See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981637 ( R-HSA-8980692 ) R-HSA-8981637 Reaction Name: RHOA GAPs stimulate RHOA GTPase activity See in Reactome R-HSA-8985594 ( R-HSA-8985586 ) R-HSA-8985594 Reaction Name: MYO9B inactivates RHOA See in Reactome R-HSA-9012761 ( R-HSA-193634 ) R-HSA-9012761 Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI See in Reactome R-HSA-9012835 ( R-HSA-8980692 ) R-HSA-9012835 Reaction Name: GDIs block activation of RHOA See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013006 ( R-HSA-8980692 ) R-HSA-9013006 Reaction Name: RHOA:GTP translocates to the ER membrane See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome
MONDO:0018997	PPP1CB	P62140	3.1.3.16 3.1.3.53	R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-2565942 R-HSA-2565942 Reactome Name: Regulation of PLK1 Activity at G2/M Transition See in Reactome R-HSA-163560 R-HSA-163560 Reactome Name: Triglyceride catabolism See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome	R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-8979227 R-HSA-8979227 Reactome Name: Triglyceride metabolism See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Circadian Clock Metabolism Signal Transduction Cell Cycle	R-HSA-163568 ( R-HSA-163560 ) R-HSA-163568 Reaction Name: phosphorylated perilipin + H2O -> perilipin + orthophosphate See in Reactome R-HSA-178178 ( R-HSA-2173788 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-3002811 ( R-HSA-2565942 ) R-HSA-3002811 Reaction Name: Myosin phosphatase dephosphorylates PLK1 See in Reactome R-HSA-400382 ( R-HSA-400253 ) R-HSA-400382 Reaction Name: CSNK1E,CSNK1D phosphorylate CRY and PER proteins See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419232 ( R-HSA-5625740; R-HSA-5627117; R-HSA-5627123 ) R-HSA-419232 Reaction Name: Myosin phosphatase dephosphorylates myosin regulatory light chain See in Reactome R-HSA-5668947 ( R-HSA-5627123 ) R-HSA-5668947 Reaction Name: PAK1 phosphorylates myosin phosphatase See in Reactome R-HSA-5668978 ( R-HSA-5627123 ) R-HSA-5668978 Reaction Name: MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex See in Reactome R-HSA-5671772 ( R-HSA-5625740 ) R-HSA-5671772 Reaction Name: p-T38-PPP1R14A binds MLCP See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome
MONDO:0019086	RHOA	P61586	3.6.5.2	R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-209563 R-HSA-209563 Reactome Name: Axonal growth stimulation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-193634 R-HSA-193634 Reactome Name: Axonal growth inhibition (RHOA activation) See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-5666185 R-HSA-5666185 Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-8985586 R-HSA-8985586 Reactome Name: SLIT2:ROBO1 increases RHOA activity See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-193697 R-HSA-193697 Reactome Name: p75NTR regulates axonogenesis See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114544 ( R-HSA-416482 ) R-HSA-114544 Reaction Name: p115-RhoGEF activation of RHOA See in Reactome R-HSA-193646 ( R-HSA-209563 ) R-HSA-193646 Reaction Name: NGF binding to p75NTR inactivates RHOA See in Reactome R-HSA-193668 ( R-HSA-209563 ) R-HSA-193668 Reaction Name: p75NTR and RHOA-GDI interact See in Reactome R-HSA-193696 ( R-HSA-193634 ) R-HSA-193696 Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA See in Reactome R-HSA-194518 ( R-HSA-193634 ) R-HSA-194518 Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth See in Reactome R-HSA-202692 ( R-HSA-198203; R-HSA-392451 ) R-HSA-202692 Reaction Name: PIP3 binds to RhoA and activates it See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-3858495 ( R-HSA-4086400; R-HSA-5663220 ) R-HSA-3858495 Reaction Name: DAAM1 recruits GTP-bound RHOA See in Reactome R-HSA-3928576 ( R-HSA-3928662 ) R-HSA-3928576 Reaction Name: RHOA:GTP binds ROCK, activating it See in Reactome R-HSA-3928577 ( R-HSA-3928662 ) R-HSA-3928577 Reaction Name: ROCK phosphorylates LIMK1,2 See in Reactome R-HSA-3928592 ( R-HSA-3928662 ) R-HSA-3928592 Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it See in Reactome R-HSA-3928616 ( R-HSA-3928663 ) R-HSA-3928616 Reaction Name: Activated ROCK phosphorylates MRLCs See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-3928651 ( R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416588 ( R-HSA-416572 ) R-HSA-416588 Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF See in Reactome R-HSA-419049 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-419049 Reaction Name: ROCK activation by RHO See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419087 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419087 Reaction Name: LIM kinase phosphorylation by ROCK See in Reactome R-HSA-419166 ( R-HSA-416482 ) R-HSA-419166 Reaction Name: GEFs activate RhoA,B,C See in Reactome R-HSA-419197 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419197 Reaction Name: Myosin regulatory light chain phosphorylation by ROCK See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5228992 ( R-HSA-4420097 ) R-HSA-5228992 Reaction Name: ROCK1,ROCK2 are activated See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5665982 ( R-HSA-5663220 ) R-HSA-5665982 Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 See in Reactome R-HSA-5665989 ( R-HSA-5663220 ) R-HSA-5665989 Reaction Name: DIAPH1 binds RHOA:GTP See in Reactome R-HSA-5666178 ( R-HSA-5666185 ) R-HSA-5666178 Reaction Name: RTKN binds RHOA, RHOC or RHOB See in Reactome R-HSA-5666197 ( R-HSA-5666185 ) R-HSA-5666197 Reaction Name: RHOA:GTP:RTKN binds LIN7B See in Reactome R-HSA-5666216 ( R-HSA-5666185 ) R-HSA-5666216 Reaction Name: RHOA:GTP:RTKN binds TAX1BP3 See in Reactome R-HSA-5667008 ( R-HSA-5666185 ) R-HSA-5667008 Reaction Name: RHOA:GTP binds RHPN1 or RHPN2 See in Reactome R-HSA-5667052 ( R-HSA-5666185 ) R-HSA-5667052 Reaction Name: ROPN1 binds RHOA:GTP:RHPN1 See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5690843 ( R-HSA-5689896 ) R-HSA-5690843 Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA See in Reactome R-HSA-6785648 ( R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8849082 ( R-HSA-8849471 ) R-HSA-8849082 Reaction Name: ARHGAP35 stimulates RHOA GTPase activity See in Reactome R-HSA-8849085 ( R-HSA-8849471 ) R-HSA-8849085 Reaction Name: ARHGAP35 binds RHOA:GTP See in Reactome R-HSA-8980691 ( R-HSA-8980692 ) R-HSA-8980691 Reaction Name: RHOA GEFs activate RHOA See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981637 ( R-HSA-8980692 ) R-HSA-8981637 Reaction Name: RHOA GAPs stimulate RHOA GTPase activity See in Reactome R-HSA-8985594 ( R-HSA-8985586 ) R-HSA-8985594 Reaction Name: MYO9B inactivates RHOA See in Reactome R-HSA-9012761 ( R-HSA-193634 ) R-HSA-9012761 Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI See in Reactome R-HSA-9012835 ( R-HSA-8980692 ) R-HSA-9012835 Reaction Name: GDIs block activation of RHOA See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013006 ( R-HSA-8980692 ) R-HSA-9013006 Reaction Name: RHOA:GTP translocates to the ER membrane See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome
MONDO:0021100	RHOA	P61586	3.6.5.2	R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-209563 R-HSA-209563 Reactome Name: Axonal growth stimulation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-193634 R-HSA-193634 Reactome Name: Axonal growth inhibition (RHOA activation) See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-5666185 R-HSA-5666185 Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-8985586 R-HSA-8985586 Reactome Name: SLIT2:ROBO1 increases RHOA activity See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-193697 R-HSA-193697 Reactome Name: p75NTR regulates axonogenesis See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114544 ( R-HSA-416482 ) R-HSA-114544 Reaction Name: p115-RhoGEF activation of RHOA See in Reactome R-HSA-193646 ( R-HSA-209563 ) R-HSA-193646 Reaction Name: NGF binding to p75NTR inactivates RHOA See in Reactome R-HSA-193668 ( R-HSA-209563 ) R-HSA-193668 Reaction Name: p75NTR and RHOA-GDI interact See in Reactome R-HSA-193696 ( R-HSA-193634 ) R-HSA-193696 Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA See in Reactome R-HSA-194518 ( R-HSA-193634 ) R-HSA-194518 Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth See in Reactome R-HSA-202692 ( R-HSA-198203; R-HSA-392451 ) R-HSA-202692 Reaction Name: PIP3 binds to RhoA and activates it See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-3858495 ( R-HSA-4086400; R-HSA-5663220 ) R-HSA-3858495 Reaction Name: DAAM1 recruits GTP-bound RHOA See in Reactome R-HSA-3928576 ( R-HSA-3928662 ) R-HSA-3928576 Reaction Name: RHOA:GTP binds ROCK, activating it See in Reactome R-HSA-3928577 ( R-HSA-3928662 ) R-HSA-3928577 Reaction Name: ROCK phosphorylates LIMK1,2 See in Reactome R-HSA-3928592 ( R-HSA-3928662 ) R-HSA-3928592 Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it See in Reactome R-HSA-3928616 ( R-HSA-3928663 ) R-HSA-3928616 Reaction Name: Activated ROCK phosphorylates MRLCs See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-3928651 ( R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416588 ( R-HSA-416572 ) R-HSA-416588 Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF See in Reactome R-HSA-419049 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-419049 Reaction Name: ROCK activation by RHO See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419087 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419087 Reaction Name: LIM kinase phosphorylation by ROCK See in Reactome R-HSA-419166 ( R-HSA-416482 ) R-HSA-419166 Reaction Name: GEFs activate RhoA,B,C See in Reactome R-HSA-419197 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419197 Reaction Name: Myosin regulatory light chain phosphorylation by ROCK See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5228992 ( R-HSA-4420097 ) R-HSA-5228992 Reaction Name: ROCK1,ROCK2 are activated See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5665982 ( R-HSA-5663220 ) R-HSA-5665982 Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 See in Reactome R-HSA-5665989 ( R-HSA-5663220 ) R-HSA-5665989 Reaction Name: DIAPH1 binds RHOA:GTP See in Reactome R-HSA-5666178 ( R-HSA-5666185 ) R-HSA-5666178 Reaction Name: RTKN binds RHOA, RHOC or RHOB See in Reactome R-HSA-5666197 ( R-HSA-5666185 ) R-HSA-5666197 Reaction Name: RHOA:GTP:RTKN binds LIN7B See in Reactome R-HSA-5666216 ( R-HSA-5666185 ) R-HSA-5666216 Reaction Name: RHOA:GTP:RTKN binds TAX1BP3 See in Reactome R-HSA-5667008 ( R-HSA-5666185 ) R-HSA-5667008 Reaction Name: RHOA:GTP binds RHPN1 or RHPN2 See in Reactome R-HSA-5667052 ( R-HSA-5666185 ) R-HSA-5667052 Reaction Name: ROPN1 binds RHOA:GTP:RHPN1 See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5690843 ( R-HSA-5689896 ) R-HSA-5690843 Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA See in Reactome R-HSA-6785648 ( R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8849082 ( R-HSA-8849471 ) R-HSA-8849082 Reaction Name: ARHGAP35 stimulates RHOA GTPase activity See in Reactome R-HSA-8849085 ( R-HSA-8849471 ) R-HSA-8849085 Reaction Name: ARHGAP35 binds RHOA:GTP See in Reactome R-HSA-8980691 ( R-HSA-8980692 ) R-HSA-8980691 Reaction Name: RHOA GEFs activate RHOA See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981637 ( R-HSA-8980692 ) R-HSA-8981637 Reaction Name: RHOA GAPs stimulate RHOA GTPase activity See in Reactome R-HSA-8985594 ( R-HSA-8985586 ) R-HSA-8985594 Reaction Name: MYO9B inactivates RHOA See in Reactome R-HSA-9012761 ( R-HSA-193634 ) R-HSA-9012761 Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI See in Reactome R-HSA-9012835 ( R-HSA-8980692 ) R-HSA-9012835 Reaction Name: GDIs block activation of RHOA See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013006 ( R-HSA-8980692 ) R-HSA-9013006 Reaction Name: RHOA:GTP translocates to the ER membrane See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome
MONDO:0030913	RAC1	P63000	3.6.5.2	R-HSA-376172 R-HSA-376172 Reactome Name: DSCAM interactions See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-9619229 R-HSA-9619229 Reactome Name: Activation of RAC1 downstream of NMDARs See in Reactome R-HSA-428540 R-HSA-428540 Reactome Name: Activation of RAC1 See in Reactome R-HSA-428543 R-HSA-428543 Reactome Name: Inactivation of CDC42 and RAC1 See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-399954 R-HSA-399954 Reactome Name: Sema3A PAK dependent Axon repulsion See in Reactome R-HSA-9032845 R-HSA-9032845 Reactome Name: Activated NTRK2 signals through CDK5 See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-193648 R-HSA-193648 Reactome Name: NRAGE signals death through JNK See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-9032759 R-HSA-9032759 Reactome Name: NTRK2 activates RAC1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-389359 R-HSA-389359 Reactome Name: CD28 dependent Vav1 pathway See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome R-HSA-399955 R-HSA-399955 Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion See in Reactome R-HSA-5626467 R-HSA-5626467 Reactome Name: RHO GTPases activate IQGAPs See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Developmental Biology Neuronal System Vesicle-mediated transport Hemostasis Signal Transduction	R-HSA-1011598 ( R-HSA-983231 ) R-HSA-1011598 Reaction Name: DOCKs bind to RhoGEFs See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1433415 ( R-HSA-1433557 ) R-HSA-1433415 Reaction Name: Activation of RAC1 See in Reactome R-HSA-2029451 ( R-HSA-2029482 ) R-HSA-2029451 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2029454 ( R-HSA-2029482 ) R-HSA-2029454 Reaction Name: Autophosphorylation of PAK1 See in Reactome R-HSA-2029456 ( R-HSA-2029482; R-HSA-5627123 ) R-HSA-2029456 Reaction Name: RAC1 and CDC42 activate PAK1 See in Reactome R-HSA-2029465 ( R-HSA-2029482; R-HSA-4420097; R-HSA-5663213 ) R-HSA-2029465 Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) See in Reactome R-HSA-2029466 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029466 Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin See in Reactome R-HSA-2029467 ( R-HSA-2029482 ) R-HSA-2029467 Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO See in Reactome R-HSA-2029469 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029469 Reaction Name: p-ERK phosphorylates WAVEs and ABI See in Reactome R-HSA-205039 ( R-HSA-193648 ) R-HSA-205039 Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor See in Reactome R-HSA-205136 ( R-HSA-193648 ) R-HSA-205136 Reaction Name: GTP-bound RAC contributes to JNK activation See in Reactome R-HSA-2130194 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2130194 Reaction Name: ABL phosphorylates WAVEs See in Reactome R-HSA-2197690 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2197690 Reaction Name: Detachment of WASP/WAVE See in Reactome R-HSA-2316352 ( R-HSA-1445148 ) R-HSA-2316352 Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424476 ( R-HSA-2424491 ) R-HSA-2424476 Reaction Name: Activation of RAC1 by VAV2/3 See in Reactome R-HSA-2730840 ( R-HSA-2871796 ) R-HSA-2730840 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2730856 ( R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730889 ( R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-376123 ( R-HSA-376172 ) R-HSA-376123 Reaction Name: DSCAM associates with Rac1-GTP:pPAK1 See in Reactome R-HSA-3858475 ( R-HSA-4086400 ) R-HSA-3858475 Reaction Name: ppDVL recruits RAC See in Reactome R-HSA-389348 ( R-HSA-389359 ) R-HSA-389348 Reaction Name: Activation of Rac1 by pVav1 See in Reactome R-HSA-389788 ( R-HSA-389359; R-HSA-5687128 ) R-HSA-389788 Reaction Name: Activation of PAKs by RAC1 and CDC42 See in Reactome R-HSA-3928612 ( R-HSA-3928662 ) R-HSA-3928612 Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928619 ( R-HSA-3928662 ) R-HSA-3928619 Reaction Name: PAK1 binds RAC1:GTP See in Reactome R-HSA-3928620 ( R-HSA-3928662 ) R-HSA-3928620 Reaction Name: PAK1 autophosphorylates See in Reactome R-HSA-3928625 ( R-HSA-3928664 ) R-HSA-3928625 Reaction Name: PAKs autophosphorylate See in Reactome R-HSA-3928628 ( R-HSA-3928665 ) R-HSA-3928628 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928633 ( R-HSA-3928664 ) R-HSA-3928633 Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it See in Reactome R-HSA-3928640 ( R-HSA-3928664 ) R-HSA-3928640 Reaction Name: PAKs phosphorylate MLC See in Reactome R-HSA-3928641 ( R-HSA-3928664 ) R-HSA-3928641 Reaction Name: PAK binds RAC and bPIX See in Reactome R-HSA-3928642 ( R-HSA-3928665 ) R-HSA-3928642 Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-399928 ( R-HSA-399955 ) R-HSA-399928 Reaction Name: Recruitment of Rnd1 to Plexin A See in Reactome R-HSA-399930 ( R-HSA-399954 ) R-HSA-399930 Reaction Name: Activation of PAK by Rac1 See in Reactome R-HSA-399935 ( R-HSA-399955 ) R-HSA-399935 Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity See in Reactome R-HSA-399938 ( R-HSA-399955 ) R-HSA-399938 Reaction Name: Activation of Rac1 by FARP2 See in Reactome R-HSA-399939 ( R-HSA-399954 ) R-HSA-399939 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-399941 ( R-HSA-399955 ) R-HSA-399941 Reaction Name: Rac1 binds PlexinA See in Reactome R-HSA-399952 ( R-HSA-399954 ) R-HSA-399952 Reaction Name: Phosphorylation of LIMK-1 by PAK See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-4093336 ( R-HSA-3928662 ) R-HSA-4093336 Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-418856 ( R-HSA-418885 ) R-HSA-418856 Reaction Name: Activation of Rac1 See in Reactome R-HSA-418865 ( R-HSA-418885 ) R-HSA-418865 Reaction Name: Recruitment of ABLIM to the plasma membrane See in Reactome R-HSA-428522 ( R-HSA-428543 ) R-HSA-428522 Reaction Name: Inactivation of RAC1 See in Reactome R-HSA-428535 ( R-HSA-428540 ) R-HSA-428535 Reaction Name: Activation of RAC1 by SOS See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442592 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-442592 Reaction Name: WASPs or WAVEs activate the ARP2/3 complex See in Reactome R-HSA-445064 ( R-HSA-445144 ) R-HSA-445064 Reaction Name: Activation of Rac1 by VAV2 See in Reactome R-HSA-445072 ( R-HSA-445144 ) R-HSA-445072 Reaction Name: Interaction of PAK1 with Rac1-GTP See in Reactome R-HSA-451347 ( R-HSA-376172 ) R-HSA-451347 Reaction Name: Activation of JNK by DSCAM See in Reactome R-HSA-451366 ( R-HSA-376172 ) R-HSA-451366 Reaction Name: Activation of p38MAPK by DSCAM See in Reactome R-HSA-5218827 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218827 Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1 See in Reactome R-HSA-5218839 ( R-HSA-4420097 ) R-HSA-5218839 Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1 See in Reactome R-HSA-5218841 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218841 Reaction Name: NADPH oxidase 2 generates superoxide from oxygen See in Reactome R-HSA-5218850 ( R-HSA-4420097 ) R-HSA-5218850 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-5357445 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357445 Reaction Name: PAK1-3 dimer disassociates See in Reactome R-HSA-5357472 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357472 Reaction Name: PAK1-3 autophosphorylates See in Reactome R-HSA-5357483 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357483 Reaction Name: RAC1 binds PAK1-3 See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5626469 ( R-HSA-5626467 ) R-HSA-5626469 Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs See in Reactome R-HSA-5626507 ( R-HSA-5626467 ) R-HSA-5626507 Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin See in Reactome R-HSA-5626549 ( R-HSA-5626467 ) R-HSA-5626549 Reaction Name: IQGAPs bind CALM1 See in Reactome R-HSA-5627775 ( R-HSA-5627123; R-HSA-5687128 ) R-HSA-5627775 Reaction Name: Autophosphorylation of PAK1,2,3 See in Reactome R-HSA-5663232 ( R-HSA-5663220 ) R-HSA-5663232 Reaction Name: FMNL1 binds RAC1:GTP See in Reactome R-HSA-5665659 ( R-HSA-5663220 ) R-HSA-5665659 Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin See in Reactome R-HSA-5665802 ( R-HSA-5663220 ) R-HSA-5665802 Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin See in Reactome R-HSA-5665809 ( R-HSA-5663220 ) R-HSA-5665809 Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments See in Reactome R-HSA-5668714 ( R-HSA-5668599 ) R-HSA-5668714 Reaction Name: RAC1:GTP binds NOX1 complex See in Reactome R-HSA-5668718 ( R-HSA-5668599 ) R-HSA-5668718 Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668731 ( R-HSA-5668599 ) R-HSA-5668731 Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668735 ( R-HSA-5668599 ) R-HSA-5668735 Reaction Name: RAC1:GTP binds NOX3 complex See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5672304 ( R-HSA-5626467 ) R-HSA-5672304 Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 See in Reactome R-HSA-5672329 ( R-HSA-5626467 ) R-HSA-5672329 Reaction Name: IQGAP1 binds CLIP1 and microtubules See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8848618 ( R-HSA-8849471 ) R-HSA-8848618 Reaction Name: Activation of RAC1 by the PXN:CRK complex See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8951586 ( R-HSA-4420097 ) R-HSA-8951586 Reaction Name: p-VAV family:PIP3 binds RAC1:GDP See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981926 ( R-HSA-5627123 ) R-HSA-8981926 Reaction Name: RAC1 and CDC42 activate PAK3 See in Reactome R-HSA-8981931 ( R-HSA-5627123 ) R-HSA-8981931 Reaction Name: RAC1 and CDC42 activate PAK2 See in Reactome R-HSA-9013143 ( R-HSA-9013149 ) R-HSA-9013143 Reaction Name: RAC1 GEFs activate RAC1 See in Reactome R-HSA-9013144 ( R-HSA-9013149 ) R-HSA-9013144 Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9013147 ( R-HSA-9013149 ) R-HSA-9013147 Reaction Name: RAC1 GDIs block activation of RAC1 See in Reactome R-HSA-9032798 ( R-HSA-9032759 ) R-HSA-9032798 Reaction Name: DOCK3 activates RAC1 See in Reactome R-HSA-9033292 ( R-HSA-9032845 ) R-HSA-9033292 Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1 See in Reactome R-HSA-9619803 ( R-HSA-9619229 ) R-HSA-9619803 Reaction Name: p-S516-ARHGEF7 activates RAC1 See in Reactome R-HSA-9691168 ( R-HSA-9013149 ) R-HSA-9691168 Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane See in Reactome R-HSA-9691174 ( R-HSA-9013149 ) R-HSA-9691174 Reaction Name: RAC1 binds effectors at the ER membrane See in Reactome
MONDO:0032568	PAK1	Q13153	2.7.11.1	R-HSA-202433 R-HSA-202433 Reactome Name: Generation of second messenger molecules See in Reactome R-HSA-376172 R-HSA-376172 Reactome Name: DSCAM interactions See in Reactome R-HSA-428540 R-HSA-428540 Reactome Name: Activation of RAC1 See in Reactome R-HSA-399954 R-HSA-399954 Reactome Name: Sema3A PAK dependent Axon repulsion See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome R-HSA-9013424 R-HSA-9013424 Reactome Name: RHOV GTPase cycle See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-389359 R-HSA-389359 Reactome Name: CD28 dependent Vav1 pathway See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-9013148 R-HSA-9013148 Reactome Name: CDC42 GTPase cycle See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-9013409 R-HSA-9013409 Reactome Name: RHOJ GTPase cycle See in Reactome R-HSA-9013406 R-HSA-9013406 Reactome Name: RHOQ GTPase cycle See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-445355 R-HSA-445355 Reactome Name: Smooth Muscle Contraction See in Reactome R-HSA-8964616 R-HSA-8964616 Reactome Name: G beta:gamma signalling through CDC42 See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Muscle contraction Immune System Developmental Biology Signal Transduction	R-HSA-2029454 ( R-HSA-2029482 ) R-HSA-2029454 Reaction Name: Autophosphorylation of PAK1 See in Reactome R-HSA-2029456 ( R-HSA-2029482; R-HSA-5627123 ) R-HSA-2029456 Reaction Name: RAC1 and CDC42 activate PAK1 See in Reactome R-HSA-2029460 ( R-HSA-2029482; R-HSA-5627123 ) R-HSA-2029460 Reaction Name: PAK1 phosphorylates LIMK1 See in Reactome R-HSA-2730856 ( R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730887 ( R-HSA-2871796 ) R-HSA-2730887 Reaction Name: Autophosphorylation and activation of MEKK1 See in Reactome R-HSA-2730889 ( R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-376123 ( R-HSA-376172 ) R-HSA-376123 Reaction Name: DSCAM associates with Rac1-GTP:pPAK1 See in Reactome R-HSA-389788 ( R-HSA-389359; R-HSA-5687128 ) R-HSA-389788 Reaction Name: Activation of PAKs by RAC1 and CDC42 See in Reactome R-HSA-3928619 ( R-HSA-3928662 ) R-HSA-3928619 Reaction Name: PAK1 binds RAC1:GTP See in Reactome R-HSA-3928620 ( R-HSA-3928662 ) R-HSA-3928620 Reaction Name: PAK1 autophosphorylates See in Reactome R-HSA-3928625 ( R-HSA-3928664 ) R-HSA-3928625 Reaction Name: PAKs autophosphorylate See in Reactome R-HSA-3928640 ( R-HSA-3928664 ) R-HSA-3928640 Reaction Name: PAKs phosphorylate MLC See in Reactome R-HSA-3928641 ( R-HSA-3928664 ) R-HSA-3928641 Reaction Name: PAK binds RAC and bPIX See in Reactome R-HSA-399930 ( R-HSA-399954 ) R-HSA-399930 Reaction Name: Activation of PAK by Rac1 See in Reactome R-HSA-399939 ( R-HSA-399954 ) R-HSA-399939 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-399952 ( R-HSA-399954 ) R-HSA-399952 Reaction Name: Phosphorylation of LIMK-1 by PAK See in Reactome R-HSA-419232 ( R-HSA-5625740; R-HSA-5627117; R-HSA-5627123 ) R-HSA-419232 Reaction Name: Myosin phosphatase dephosphorylates myosin regulatory light chain See in Reactome R-HSA-428531 ( R-HSA-428540 ) R-HSA-428531 Reaction Name: Recruitment of PAK to NCK See in Reactome R-HSA-430183 ( R-HSA-202433 ) R-HSA-430183 Reaction Name: NCK binds PAK See in Reactome R-HSA-442832 ( R-HSA-5627123 ) R-HSA-442832 Reaction Name: PAK phosphorylates cortactin See in Reactome R-HSA-445072 ( R-HSA-445144 ) R-HSA-445072 Reaction Name: Interaction of PAK1 with Rac1-GTP See in Reactome R-HSA-445797 ( R-HSA-445355; R-HSA-5627123 ) R-HSA-445797 Reaction Name: MYLK (MLCK) Active Calmodulin Binding See in Reactome R-HSA-451347 ( R-HSA-376172 ) R-HSA-451347 Reaction Name: Activation of JNK by DSCAM See in Reactome R-HSA-451366 ( R-HSA-376172 ) R-HSA-451366 Reaction Name: Activation of p38MAPK by DSCAM See in Reactome R-HSA-5357445 ( R-HSA-5218920 ) R-HSA-5357445 Reaction Name: PAK1-3 dimer disassociates See in Reactome R-HSA-5357472 ( R-HSA-5218920 ) R-HSA-5357472 Reaction Name: PAK1-3 autophosphorylates See in Reactome R-HSA-5357477 ( R-HSA-5218920 ) R-HSA-5357477 Reaction Name: PAK1-3 phosphorylates VE-cadherin See in Reactome R-HSA-5357483 ( R-HSA-5218920 ) R-HSA-5357483 Reaction Name: RAC1 binds PAK1-3 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5627775 ( R-HSA-5627123; R-HSA-5687128 ) R-HSA-5627775 Reaction Name: Autophosphorylation of PAK1,2,3 See in Reactome R-HSA-5668947 ( R-HSA-5627123 ) R-HSA-5668947 Reaction Name: PAK1 phosphorylates myosin phosphatase See in Reactome R-HSA-5668984 ( R-HSA-5627123 ) R-HSA-5668984 Reaction Name: PAK1 or PAK2 phosphorylates MYLK See in Reactome R-HSA-5669158 ( R-HSA-5627123 ) R-HSA-5669158 Reaction Name: NF2 binds PAK1 See in Reactome R-HSA-5669240 ( R-HSA-5627123 ) R-HSA-5669240 Reaction Name: FLNA binds PAK1 See in Reactome R-HSA-5669250 ( R-HSA-5627123 ) R-HSA-5669250 Reaction Name: PAK1 phosphorylates FLNA See in Reactome R-HSA-5687086 ( R-HSA-5687128 ) R-HSA-5687086 Reaction Name: PAK1,2,3 phosphorylates MAPK6,4 See in Reactome R-HSA-8964599 ( R-HSA-8964616 ) R-HSA-8964599 Reaction Name: Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex See in Reactome R-HSA-8964604 ( R-HSA-8964616 ) R-HSA-8964604 Reaction Name: CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated See in Reactome R-HSA-8964605 ( R-HSA-8964616 ) R-HSA-8964605 Reaction Name: PAK1:ARHGEF6 complex binds G-protein beta-gamma complex See in Reactome R-HSA-8964614 ( R-HSA-8964616 ) R-HSA-8964614 Reaction Name: PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated See in Reactome R-HSA-8964619 ( R-HSA-8964616 ) R-HSA-8964619 Reaction Name: PAK1 binds ARHGEF6 See in Reactome R-HSA-8964634 ( R-HSA-8964616 ) R-HSA-8964634 Reaction Name: CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9013157 ( R-HSA-9013148 ) R-HSA-9013157 Reaction Name: CDC42 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9017507 ( R-HSA-9013409 ) R-HSA-9017507 Reaction Name: RHOJ binds effectors at the plasma membrane See in Reactome R-HSA-9018746 ( R-HSA-9013406 ) R-HSA-9018746 Reaction Name: RHOQ binds effectors at the plasma membrane See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome R-HSA-9018766 ( R-HSA-9013420 ) R-HSA-9018766 Reaction Name: RHOU binds effectors at the plasma membrane See in Reactome R-HSA-9018794 ( R-HSA-9013424 ) R-HSA-9018794 Reaction Name: RHOV binds effectors at the plasma membrane See in Reactome R-HSA-9018808 ( R-HSA-9013423 ) R-HSA-9018808 Reaction Name: RAC3 binds effectors at the plasma membrane See in Reactome
MONDO:0032884	RHOA	P61586	3.6.5.2	R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-209563 R-HSA-209563 Reactome Name: Axonal growth stimulation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-193634 R-HSA-193634 Reactome Name: Axonal growth inhibition (RHOA activation) See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-5666185 R-HSA-5666185 Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-8985586 R-HSA-8985586 Reactome Name: SLIT2:ROBO1 increases RHOA activity See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-193697 R-HSA-193697 Reactome Name: p75NTR regulates axonogenesis See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114544 ( R-HSA-416482 ) R-HSA-114544 Reaction Name: p115-RhoGEF activation of RHOA See in Reactome R-HSA-193646 ( R-HSA-209563 ) R-HSA-193646 Reaction Name: NGF binding to p75NTR inactivates RHOA See in Reactome R-HSA-193668 ( R-HSA-209563 ) R-HSA-193668 Reaction Name: p75NTR and RHOA-GDI interact See in Reactome R-HSA-193696 ( R-HSA-193634 ) R-HSA-193696 Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA See in Reactome R-HSA-194518 ( R-HSA-193634 ) R-HSA-194518 Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth See in Reactome R-HSA-202692 ( R-HSA-198203; R-HSA-392451 ) R-HSA-202692 Reaction Name: PIP3 binds to RhoA and activates it See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-3858495 ( R-HSA-4086400; R-HSA-5663220 ) R-HSA-3858495 Reaction Name: DAAM1 recruits GTP-bound RHOA See in Reactome R-HSA-3928576 ( R-HSA-3928662 ) R-HSA-3928576 Reaction Name: RHOA:GTP binds ROCK, activating it See in Reactome R-HSA-3928577 ( R-HSA-3928662 ) R-HSA-3928577 Reaction Name: ROCK phosphorylates LIMK1,2 See in Reactome R-HSA-3928592 ( R-HSA-3928662 ) R-HSA-3928592 Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it See in Reactome R-HSA-3928616 ( R-HSA-3928663 ) R-HSA-3928616 Reaction Name: Activated ROCK phosphorylates MRLCs See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-3928651 ( R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416588 ( R-HSA-416572 ) R-HSA-416588 Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF See in Reactome R-HSA-419049 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-419049 Reaction Name: ROCK activation by RHO See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419087 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419087 Reaction Name: LIM kinase phosphorylation by ROCK See in Reactome R-HSA-419166 ( R-HSA-416482 ) R-HSA-419166 Reaction Name: GEFs activate RhoA,B,C See in Reactome R-HSA-419197 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419197 Reaction Name: Myosin regulatory light chain phosphorylation by ROCK See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5228992 ( R-HSA-4420097 ) R-HSA-5228992 Reaction Name: ROCK1,ROCK2 are activated See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5665982 ( R-HSA-5663220 ) R-HSA-5665982 Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 See in Reactome R-HSA-5665989 ( R-HSA-5663220 ) R-HSA-5665989 Reaction Name: DIAPH1 binds RHOA:GTP See in Reactome R-HSA-5666178 ( R-HSA-5666185 ) R-HSA-5666178 Reaction Name: RTKN binds RHOA, RHOC or RHOB See in Reactome R-HSA-5666197 ( R-HSA-5666185 ) R-HSA-5666197 Reaction Name: RHOA:GTP:RTKN binds LIN7B See in Reactome R-HSA-5666216 ( R-HSA-5666185 ) R-HSA-5666216 Reaction Name: RHOA:GTP:RTKN binds TAX1BP3 See in Reactome R-HSA-5667008 ( R-HSA-5666185 ) R-HSA-5667008 Reaction Name: RHOA:GTP binds RHPN1 or RHPN2 See in Reactome R-HSA-5667052 ( R-HSA-5666185 ) R-HSA-5667052 Reaction Name: ROPN1 binds RHOA:GTP:RHPN1 See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5690843 ( R-HSA-5689896 ) R-HSA-5690843 Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA See in Reactome R-HSA-6785648 ( R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8849082 ( R-HSA-8849471 ) R-HSA-8849082 Reaction Name: ARHGAP35 stimulates RHOA GTPase activity See in Reactome R-HSA-8849085 ( R-HSA-8849471 ) R-HSA-8849085 Reaction Name: ARHGAP35 binds RHOA:GTP See in Reactome R-HSA-8980691 ( R-HSA-8980692 ) R-HSA-8980691 Reaction Name: RHOA GEFs activate RHOA See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981637 ( R-HSA-8980692 ) R-HSA-8981637 Reaction Name: RHOA GAPs stimulate RHOA GTPase activity See in Reactome R-HSA-8985594 ( R-HSA-8985586 ) R-HSA-8985594 Reaction Name: MYO9B inactivates RHOA See in Reactome R-HSA-9012761 ( R-HSA-193634 ) R-HSA-9012761 Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI See in Reactome R-HSA-9012835 ( R-HSA-8980692 ) R-HSA-9012835 Reaction Name: GDIs block activation of RHOA See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013006 ( R-HSA-8980692 ) R-HSA-9013006 Reaction Name: RHOA:GTP translocates to the ER membrane See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome
MONDO:0035124	RHOA	P61586	3.6.5.2	R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-209563 R-HSA-209563 Reactome Name: Axonal growth stimulation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-193634 R-HSA-193634 Reactome Name: Axonal growth inhibition (RHOA activation) See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-5666185 R-HSA-5666185 Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-8985586 R-HSA-8985586 Reactome Name: SLIT2:ROBO1 increases RHOA activity See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-193697 R-HSA-193697 Reactome Name: p75NTR regulates axonogenesis See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114544 ( R-HSA-416482 ) R-HSA-114544 Reaction Name: p115-RhoGEF activation of RHOA See in Reactome R-HSA-193646 ( R-HSA-209563 ) R-HSA-193646 Reaction Name: NGF binding to p75NTR inactivates RHOA See in Reactome R-HSA-193668 ( R-HSA-209563 ) R-HSA-193668 Reaction Name: p75NTR and RHOA-GDI interact See in Reactome R-HSA-193696 ( R-HSA-193634 ) R-HSA-193696 Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA See in Reactome R-HSA-194518 ( R-HSA-193634 ) R-HSA-194518 Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth See in Reactome R-HSA-202692 ( R-HSA-198203; R-HSA-392451 ) R-HSA-202692 Reaction Name: PIP3 binds to RhoA and activates it See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-3858495 ( R-HSA-4086400; R-HSA-5663220 ) R-HSA-3858495 Reaction Name: DAAM1 recruits GTP-bound RHOA See in Reactome R-HSA-3928576 ( R-HSA-3928662 ) R-HSA-3928576 Reaction Name: RHOA:GTP binds ROCK, activating it See in Reactome R-HSA-3928577 ( R-HSA-3928662 ) R-HSA-3928577 Reaction Name: ROCK phosphorylates LIMK1,2 See in Reactome R-HSA-3928592 ( R-HSA-3928662 ) R-HSA-3928592 Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it See in Reactome R-HSA-3928616 ( R-HSA-3928663 ) R-HSA-3928616 Reaction Name: Activated ROCK phosphorylates MRLCs See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-3928651 ( R-HSA-3928663 ) R-HSA-3928651 Reaction Name: NGEF exchanges GTP for GDP on RHOA See in Reactome R-HSA-416559 ( R-HSA-416550 ) R-HSA-416559 Reaction Name: Inactivation of Rho-GTP by p190RhoGAP See in Reactome R-HSA-416588 ( R-HSA-416572 ) R-HSA-416588 Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF See in Reactome R-HSA-419049 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-419049 Reaction Name: ROCK activation by RHO See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419087 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419087 Reaction Name: LIM kinase phosphorylation by ROCK See in Reactome R-HSA-419166 ( R-HSA-416482 ) R-HSA-419166 Reaction Name: GEFs activate RhoA,B,C See in Reactome R-HSA-419197 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419197 Reaction Name: Myosin regulatory light chain phosphorylation by ROCK See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5228992 ( R-HSA-4420097 ) R-HSA-5228992 Reaction Name: ROCK1,ROCK2 are activated See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5665982 ( R-HSA-5663220 ) R-HSA-5665982 Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 See in Reactome R-HSA-5665989 ( R-HSA-5663220 ) R-HSA-5665989 Reaction Name: DIAPH1 binds RHOA:GTP See in Reactome R-HSA-5666178 ( R-HSA-5666185 ) R-HSA-5666178 Reaction Name: RTKN binds RHOA, RHOC or RHOB See in Reactome R-HSA-5666197 ( R-HSA-5666185 ) R-HSA-5666197 Reaction Name: RHOA:GTP:RTKN binds LIN7B See in Reactome R-HSA-5666216 ( R-HSA-5666185 ) R-HSA-5666216 Reaction Name: RHOA:GTP:RTKN binds TAX1BP3 See in Reactome R-HSA-5667008 ( R-HSA-5666185 ) R-HSA-5667008 Reaction Name: RHOA:GTP binds RHPN1 or RHPN2 See in Reactome R-HSA-5667052 ( R-HSA-5666185 ) R-HSA-5667052 Reaction Name: ROPN1 binds RHOA:GTP:RHPN1 See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5690843 ( R-HSA-5689896 ) R-HSA-5690843 Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA See in Reactome R-HSA-6785648 ( R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8849082 ( R-HSA-8849471 ) R-HSA-8849082 Reaction Name: ARHGAP35 stimulates RHOA GTPase activity See in Reactome R-HSA-8849085 ( R-HSA-8849471 ) R-HSA-8849085 Reaction Name: ARHGAP35 binds RHOA:GTP See in Reactome R-HSA-8980691 ( R-HSA-8980692 ) R-HSA-8980691 Reaction Name: RHOA GEFs activate RHOA See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981637 ( R-HSA-8980692 ) R-HSA-8981637 Reaction Name: RHOA GAPs stimulate RHOA GTPase activity See in Reactome R-HSA-8985594 ( R-HSA-8985586 ) R-HSA-8985594 Reaction Name: MYO9B inactivates RHOA See in Reactome R-HSA-9012761 ( R-HSA-193634 ) R-HSA-9012761 Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI See in Reactome R-HSA-9012835 ( R-HSA-8980692 ) R-HSA-9012835 Reaction Name: GDIs block activation of RHOA See in Reactome R-HSA-9013004 ( R-HSA-8980692 ) R-HSA-9013004 Reaction Name: RHOA binds effectors at the ER membrane See in Reactome R-HSA-9013006 ( R-HSA-8980692 ) R-HSA-9013006 Reaction Name: RHOA:GTP translocates to the ER membrane See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome
MONDO:0054588	PPP1CB	P62140	3.1.3.16 3.1.3.53	R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-2565942 R-HSA-2565942 Reactome Name: Regulation of PLK1 Activity at G2/M Transition See in Reactome R-HSA-163560 R-HSA-163560 Reactome Name: Triglyceride catabolism See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome	R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-8979227 R-HSA-8979227 Reactome Name: Triglyceride metabolism See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Circadian Clock Metabolism Signal Transduction Cell Cycle	R-HSA-163568 ( R-HSA-163560 ) R-HSA-163568 Reaction Name: phosphorylated perilipin + H2O -> perilipin + orthophosphate See in Reactome R-HSA-178178 ( R-HSA-2173788 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-3002811 ( R-HSA-2565942 ) R-HSA-3002811 Reaction Name: Myosin phosphatase dephosphorylates PLK1 See in Reactome R-HSA-400382 ( R-HSA-400253 ) R-HSA-400382 Reaction Name: CSNK1E,CSNK1D phosphorylate CRY and PER proteins See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419232 ( R-HSA-5625740; R-HSA-5627117; R-HSA-5627123 ) R-HSA-419232 Reaction Name: Myosin phosphatase dephosphorylates myosin regulatory light chain See in Reactome R-HSA-5668947 ( R-HSA-5627123 ) R-HSA-5668947 Reaction Name: PAK1 phosphorylates myosin phosphatase See in Reactome R-HSA-5668978 ( R-HSA-5627123 ) R-HSA-5668978 Reaction Name: MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex See in Reactome R-HSA-5671772 ( R-HSA-5625740 ) R-HSA-5671772 Reaction Name: p-T38-PPP1R14A binds MLCP See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome