MONDO:0009624 |
PLK4 |
O00444 |
2.7.11.21
|
R-HSA-380270
R-HSA-380270
Reactome Name: Recruitment of mitotic centrosome proteins and complexes
See in Reactome
R-HSA-2565942
R-HSA-2565942
Reactome Name: Regulation of PLK1 Activity at G2/M Transition
See in Reactome
R-HSA-380284
R-HSA-380284
Reactome Name: Loss of proteins required for interphase microtubule organization from the centrosome
See in Reactome
R-HSA-380320
R-HSA-380320
Reactome Name: Recruitment of NuMA to mitotic centrosomes
See in Reactome
R-HSA-5620912
R-HSA-5620912
Reactome Name: Anchoring of the basal body to the plasma membrane
See in Reactome
R-HSA-380259
R-HSA-380259
Reactome Name: Loss of Nlp from mitotic centrosomes
See in Reactome
R-HSA-8854518
|
R-HSA-380287
R-HSA-453274
R-HSA-68877
R-HSA-68886
R-HSA-69278
R-HSA-1640170
R-HSA-5617833
R-HSA-1852241
R-HSA-1852241
Reactome Name: Organelle biogenesis and maintenance
See in Reactome
R-HSA-69275
|
Cell Cycle
Organelle biogenesis and maintenance
|
R-HSA-2574840
(
R-HSA-2565942
)
R-HSA-2574840
Reaction Name: AJUBA facilitates AURKA autophosphorylation
See in Reactome
R-HSA-2574845
(
R-HSA-2565942
)
R-HSA-2574845
Reaction Name: AJUBA binds centrosome-associated AURKA
See in Reactome
R-HSA-3000310
(
R-HSA-2565942
)
R-HSA-3000319
(
R-HSA-2565942
)
R-HSA-380272
(
R-HSA-380259;
R-HSA-380284
)
R-HSA-380272
Reaction Name: Plk1-mediated phosphorylation of Nlp
See in Reactome
R-HSA-380283
(
R-HSA-380270
)
R-HSA-380283
Reaction Name: Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
See in Reactome
R-HSA-380294
(
R-HSA-380284
)
R-HSA-380294
Reaction Name: Loss of C-Nap-1 from centrosomes
See in Reactome
R-HSA-380303
(
R-HSA-380259;
R-HSA-380284
)
R-HSA-380303
Reaction Name: Dissociation of Phospho-Nlp from the centrosome
See in Reactome
R-HSA-380311
(
R-HSA-380270
)
R-HSA-380311
Reaction Name: Recruitment of Plk1 to centrosomes
See in Reactome
R-HSA-380316
(
R-HSA-380320
)
R-HSA-380316
Reaction Name: Association of NuMA with microtubules
See in Reactome
R-HSA-380455
(
R-HSA-380270
)
R-HSA-380455
Reaction Name: Recruitment of CDK11p58 to the centrosomes
See in Reactome
R-HSA-380508
(
R-HSA-380320
)
R-HSA-380508
Reaction Name: Translocation of NuMA to the centrosomes
See in Reactome
R-HSA-5617816
(
R-HSA-5620912
)
R-HSA-5617816
Reaction Name: RAB3IP stimulates nucleotide exchange on RAB8A
See in Reactome
R-HSA-5626220
(
R-HSA-5620912
)
R-HSA-5626220
Reaction Name: C2CD3 binds the mother centriole
See in Reactome
R-HSA-5626223
(
R-HSA-5620912
)
R-HSA-5626223
Reaction Name: C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole
See in Reactome
R-HSA-5626227
(
R-HSA-5620912
)
R-HSA-5626227
Reaction Name: CP110 and CEP97 dissociate from the centriole
See in Reactome
R-HSA-5626228
(
R-HSA-5620912
)
R-HSA-5626228
Reaction Name: The distal appendage proteins recruit TTBK2
See in Reactome
R-HSA-5626681
(
R-HSA-5620912
)
R-HSA-5626681
Reaction Name: Recruitment of transition zone proteins
See in Reactome
R-HSA-5626699
(
R-HSA-5620912
)
R-HSA-5626699
Reaction Name: MARK4 binds ODF2 in the centriole
See in Reactome
R-HSA-5638009
(
R-HSA-5620912
)
R-HSA-5638009
Reaction Name: CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body
See in Reactome
R-HSA-8853405
(
R-HSA-8854518
)
R-HSA-8853405
Reaction Name: TPX2 binds AURKA at centrosomes
See in Reactome
R-HSA-8853419
(
R-HSA-8854518
)
R-HSA-8853419
Reaction Name: TPX2 promotes AURKA autophosphorylation
See in Reactome
|
MONDO:0011464 |
TTBK2 |
Q6IQ55 |
2.7.11.1
|
R-HSA-5620912
R-HSA-5620912
Reactome Name: Anchoring of the basal body to the plasma membrane
See in Reactome
|
R-HSA-1852241
R-HSA-1852241
Reactome Name: Organelle biogenesis and maintenance
See in Reactome
R-HSA-5617833
|
Organelle biogenesis and maintenance
|
R-HSA-5617816
(
R-HSA-5620912
)
R-HSA-5617816
Reaction Name: RAB3IP stimulates nucleotide exchange on RAB8A
See in Reactome
R-HSA-5626227
(
R-HSA-5620912
)
R-HSA-5626227
Reaction Name: CP110 and CEP97 dissociate from the centriole
See in Reactome
R-HSA-5626228
(
R-HSA-5620912
)
R-HSA-5626228
Reaction Name: The distal appendage proteins recruit TTBK2
See in Reactome
R-HSA-5626681
(
R-HSA-5620912
)
R-HSA-5626681
Reaction Name: Recruitment of transition zone proteins
See in Reactome
R-HSA-5626699
(
R-HSA-5620912
)
R-HSA-5626699
Reaction Name: MARK4 binds ODF2 in the centriole
See in Reactome
R-HSA-5638009
(
R-HSA-5620912
)
R-HSA-5638009
Reaction Name: CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body
See in Reactome
|
MONDO:0014088 |
CSNK1D |
P48730 |
2.7.11.26
2.7.11.1
|
R-HSA-380270
R-HSA-380270
Reactome Name: Recruitment of mitotic centrosome proteins and complexes
See in Reactome
R-HSA-400253
R-HSA-204005
R-HSA-204005
Reactome Name: COPII-mediated vesicle transport
See in Reactome
R-HSA-2565942
R-HSA-2565942
Reactome Name: Regulation of PLK1 Activity at G2/M Transition
See in Reactome
R-HSA-380284
R-HSA-380284
Reactome Name: Loss of proteins required for interphase microtubule organization from the centrosome
See in Reactome
R-HSA-380320
R-HSA-380320
Reactome Name: Recruitment of NuMA to mitotic centrosomes
See in Reactome
R-HSA-6791226
R-HSA-6791226
Reactome Name: Major pathway of rRNA processing in the nucleolus and cytosol
See in Reactome
R-HSA-5620912
R-HSA-5620912
Reactome Name: Anchoring of the basal body to the plasma membrane
See in Reactome
R-HSA-380259
R-HSA-380259
Reactome Name: Loss of Nlp from mitotic centrosomes
See in Reactome
R-HSA-8854518
|
R-HSA-380287
R-HSA-68886
R-HSA-1852241
R-HSA-1852241
Reactome Name: Organelle biogenesis and maintenance
See in Reactome
R-HSA-8953854
R-HSA-8868773
R-HSA-8868773
Reactome Name: rRNA processing in the nucleus and cytosol
See in Reactome
R-HSA-453274
R-HSA-392499
R-HSA-68877
R-HSA-199991
R-HSA-446203
R-HSA-446203
Reactome Name: Asparagine N-linked glycosylation
See in Reactome
R-HSA-69278
R-HSA-72312
R-HSA-199977
R-HSA-199977
Reactome Name: ER to Golgi Anterograde Transport
See in Reactome
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5617833
R-HSA-948021
R-HSA-948021
Reactome Name: Transport to the Golgi and subsequent modification
See in Reactome
R-HSA-69275
R-HSA-5653656
|
Circadian Clock
Organelle biogenesis and maintenance
Metabolism of RNA
Metabolism of proteins
Cell Cycle
Vesicle-mediated transport
|
R-HSA-1856948
(
R-HSA-400253
)
R-HSA-1856948
Reaction Name: Formation of CRY:PER:Kinase complex
See in Reactome
R-HSA-2574840
(
R-HSA-2565942
)
R-HSA-2574840
Reaction Name: AJUBA facilitates AURKA autophosphorylation
See in Reactome
R-HSA-2574845
(
R-HSA-2565942
)
R-HSA-2574845
Reaction Name: AJUBA binds centrosome-associated AURKA
See in Reactome
R-HSA-3000310
(
R-HSA-2565942
)
R-HSA-3000319
(
R-HSA-2565942
)
R-HSA-380272
(
R-HSA-380259;
R-HSA-380284
)
R-HSA-380272
Reaction Name: Plk1-mediated phosphorylation of Nlp
See in Reactome
R-HSA-380283
(
R-HSA-380270
)
R-HSA-380283
Reaction Name: Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
See in Reactome
R-HSA-380294
(
R-HSA-380284
)
R-HSA-380294
Reaction Name: Loss of C-Nap-1 from centrosomes
See in Reactome
R-HSA-380303
(
R-HSA-380259;
R-HSA-380284
)
R-HSA-380303
Reaction Name: Dissociation of Phospho-Nlp from the centrosome
See in Reactome
R-HSA-380311
(
R-HSA-380270
)
R-HSA-380311
Reaction Name: Recruitment of Plk1 to centrosomes
See in Reactome
R-HSA-380316
(
R-HSA-380320
)
R-HSA-380316
Reaction Name: Association of NuMA with microtubules
See in Reactome
R-HSA-380455
(
R-HSA-380270
)
R-HSA-380455
Reaction Name: Recruitment of CDK11p58 to the centrosomes
See in Reactome
R-HSA-380508
(
R-HSA-380320
)
R-HSA-380508
Reaction Name: Translocation of NuMA to the centrosomes
See in Reactome
R-HSA-400256
(
R-HSA-400253
)
R-HSA-400256
Reaction Name: CRY:PER heterodimer binds the BMAL1:CLOCK/NPAS2 heterodimer
See in Reactome
R-HSA-400382
(
R-HSA-400253
)
R-HSA-400382
Reaction Name: CSNK1E,CSNK1D phosphorylate CRY and PER proteins
See in Reactome
R-HSA-549385
(
R-HSA-400253
)
R-HSA-549385
Reaction Name: CRY:PER:Kinase complex translocates to the nucleus
See in Reactome
R-HSA-5617816
(
R-HSA-5620912
)
R-HSA-5617816
Reaction Name: RAB3IP stimulates nucleotide exchange on RAB8A
See in Reactome
R-HSA-5626220
(
R-HSA-5620912
)
R-HSA-5626220
Reaction Name: C2CD3 binds the mother centriole
See in Reactome
R-HSA-5626223
(
R-HSA-5620912
)
R-HSA-5626223
Reaction Name: C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole
See in Reactome
R-HSA-5626227
(
R-HSA-5620912
)
R-HSA-5626227
Reaction Name: CP110 and CEP97 dissociate from the centriole
See in Reactome
R-HSA-5626228
(
R-HSA-5620912
)
R-HSA-5626228
Reaction Name: The distal appendage proteins recruit TTBK2
See in Reactome
R-HSA-5626681
(
R-HSA-5620912
)
R-HSA-5626681
Reaction Name: Recruitment of transition zone proteins
See in Reactome
R-HSA-5626699
(
R-HSA-5620912
)
R-HSA-5626699
Reaction Name: MARK4 binds ODF2 in the centriole
See in Reactome
R-HSA-5638009
(
R-HSA-5620912
)
R-HSA-5638009
Reaction Name: CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body
See in Reactome
R-HSA-5694441
(
R-HSA-204005
)
R-HSA-6791223
(
R-HSA-6791226
)
R-HSA-6791223
Reaction Name: 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol
See in Reactome
R-HSA-8853405
(
R-HSA-8854518
)
R-HSA-8853405
Reaction Name: TPX2 binds AURKA at centrosomes
See in Reactome
R-HSA-8853419
(
R-HSA-8854518
)
R-HSA-8853419
Reaction Name: TPX2 promotes AURKA autophosphorylation
See in Reactome
|
MONDO:0014256 |
NEK2 |
P51955 |
2.7.11.1
|
R-HSA-380270
R-HSA-380270
Reactome Name: Recruitment of mitotic centrosome proteins and complexes
See in Reactome
R-HSA-2565942
R-HSA-2565942
Reactome Name: Regulation of PLK1 Activity at G2/M Transition
See in Reactome
R-HSA-380284
R-HSA-380284
Reactome Name: Loss of proteins required for interphase microtubule organization from the centrosome
See in Reactome
R-HSA-380320
R-HSA-380320
Reactome Name: Recruitment of NuMA to mitotic centrosomes
See in Reactome
R-HSA-179409
R-HSA-179409
Reactome Name: APC-Cdc20 mediated degradation of Nek2A
See in Reactome
R-HSA-5620912
R-HSA-5620912
Reactome Name: Anchoring of the basal body to the plasma membrane
See in Reactome
R-HSA-380259
R-HSA-380259
Reactome Name: Loss of Nlp from mitotic centrosomes
See in Reactome
R-HSA-8854518
|
R-HSA-174143
R-HSA-174143
Reactome Name: APC/C-mediated degradation of cell cycle proteins
See in Reactome
R-HSA-68877
R-HSA-176409
R-HSA-176409
Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-176814
R-HSA-176814
Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-1852241
R-HSA-1852241
Reactome Name: Organelle biogenesis and maintenance
See in Reactome
R-HSA-453274
R-HSA-453276
R-HSA-453276
Reactome Name: Regulation of mitotic cell cycle
See in Reactome
R-HSA-68886
R-HSA-69278
R-HSA-179419
R-HSA-179419
Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
See in Reactome
R-HSA-1640170
R-HSA-5617833
R-HSA-380287
R-HSA-69275
|
Organelle biogenesis and maintenance
Cell Cycle
|
R-HSA-179410
(
R-HSA-179409
)
R-HSA-179410
Reaction Name: Association of Nek2A with MCC:APC/C
See in Reactome
R-HSA-179417
(
R-HSA-179409
)
R-HSA-179421
(
R-HSA-179409
)
R-HSA-179421
Reaction Name: Degradation of multiubiquitinated Nek2A
See in Reactome
R-HSA-2574840
(
R-HSA-2565942
)
R-HSA-2574840
Reaction Name: AJUBA facilitates AURKA autophosphorylation
See in Reactome
R-HSA-2574845
(
R-HSA-2565942
)
R-HSA-2574845
Reaction Name: AJUBA binds centrosome-associated AURKA
See in Reactome
R-HSA-3000310
(
R-HSA-2565942
)
R-HSA-3000319
(
R-HSA-2565942
)
R-HSA-380272
(
R-HSA-380259;
R-HSA-380284
)
R-HSA-380272
Reaction Name: Plk1-mediated phosphorylation of Nlp
See in Reactome
R-HSA-380283
(
R-HSA-380270
)
R-HSA-380283
Reaction Name: Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
See in Reactome
R-HSA-380294
(
R-HSA-380284
)
R-HSA-380294
Reaction Name: Loss of C-Nap-1 from centrosomes
See in Reactome
R-HSA-380303
(
R-HSA-380259;
R-HSA-380284
)
R-HSA-380303
Reaction Name: Dissociation of Phospho-Nlp from the centrosome
See in Reactome
R-HSA-380311
(
R-HSA-380270
)
R-HSA-380311
Reaction Name: Recruitment of Plk1 to centrosomes
See in Reactome
R-HSA-380316
(
R-HSA-380320
)
R-HSA-380316
Reaction Name: Association of NuMA with microtubules
See in Reactome
R-HSA-380455
(
R-HSA-380270
)
R-HSA-380455
Reaction Name: Recruitment of CDK11p58 to the centrosomes
See in Reactome
R-HSA-380508
(
R-HSA-380320
)
R-HSA-380508
Reaction Name: Translocation of NuMA to the centrosomes
See in Reactome
R-HSA-5617816
(
R-HSA-5620912
)
R-HSA-5617816
Reaction Name: RAB3IP stimulates nucleotide exchange on RAB8A
See in Reactome
R-HSA-5626220
(
R-HSA-5620912
)
R-HSA-5626220
Reaction Name: C2CD3 binds the mother centriole
See in Reactome
R-HSA-5626223
(
R-HSA-5620912
)
R-HSA-5626223
Reaction Name: C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole
See in Reactome
R-HSA-5626227
(
R-HSA-5620912
)
R-HSA-5626227
Reaction Name: CP110 and CEP97 dissociate from the centriole
See in Reactome
R-HSA-5626228
(
R-HSA-5620912
)
R-HSA-5626228
Reaction Name: The distal appendage proteins recruit TTBK2
See in Reactome
R-HSA-5626681
(
R-HSA-5620912
)
R-HSA-5626681
Reaction Name: Recruitment of transition zone proteins
See in Reactome
R-HSA-5626699
(
R-HSA-5620912
)
R-HSA-5626699
Reaction Name: MARK4 binds ODF2 in the centriole
See in Reactome
R-HSA-5638009
(
R-HSA-5620912
)
R-HSA-5638009
Reaction Name: CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body
See in Reactome
R-HSA-8853405
(
R-HSA-8854518
)
R-HSA-8853405
Reaction Name: TPX2 binds AURKA at centrosomes
See in Reactome
R-HSA-8853419
(
R-HSA-8854518
)
R-HSA-8853419
Reaction Name: TPX2 promotes AURKA autophosphorylation
See in Reactome
|
MONDO:0014359 |
PRKACA |
P17612 |
2.7.11.11
|
R-HSA-442720
R-HSA-442720
Reactome Name: CREB1 phosphorylation through the activation of Adenylate Cyclase
See in Reactome
R-HSA-9022692
R-HSA-9022692
Reactome Name: Regulation of MECP2 expression and activity
See in Reactome
R-HSA-381676
R-HSA-381676
Reactome Name: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
See in Reactome
R-HSA-380259
R-HSA-380259
Reactome Name: Loss of Nlp from mitotic centrosomes
See in Reactome
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-432040
R-HSA-432040
Reactome Name: Vasopressin regulates renal water homeostasis via Aquaporins
See in Reactome
R-HSA-380270
R-HSA-380270
Reactome Name: Recruitment of mitotic centrosome proteins and complexes
See in Reactome
R-HSA-5610783
R-HSA-5610783
Reactome Name: Degradation of GLI2 by the proteasome
See in Reactome
R-HSA-111931
R-HSA-111931
Reactome Name: PKA-mediated phosphorylation of CREB
See in Reactome
R-HSA-180024
R-HSA-5610787
R-HSA-163615
R-HSA-5610785
R-HSA-5610785
Reactome Name: GLI3 is processed to GLI3R by the proteasome
See in Reactome
R-HSA-164378
R-HSA-164378
Reactome Name: PKA activation in glucagon signalling
See in Reactome
R-HSA-5578775
R-HSA-8853659
R-HSA-9010642
R-HSA-8854518
R-HSA-4420097
R-HSA-380284
R-HSA-380284
Reactome Name: Loss of proteins required for interphase microtubule organization from the centrosome
See in Reactome
R-HSA-5687128
R-HSA-163560
R-HSA-5610780
R-HSA-5610780
Reactome Name: Degradation of GLI1 by the proteasome
See in Reactome
R-HSA-5620912
R-HSA-5620912
Reactome Name: Anchoring of the basal body to the plasma membrane
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-8963896
R-HSA-392517
R-HSA-163358
R-HSA-163358
Reactome Name: PKA-mediated phosphorylation of key metabolic factors
See in Reactome
R-HSA-422356
R-HSA-422356
Reactome Name: Regulation of insulin secretion
See in Reactome
R-HSA-2565942
R-HSA-2565942
Reactome Name: Regulation of PLK1 Activity at G2/M Transition
See in Reactome
R-HSA-380320
R-HSA-380320
Reactome Name: Recruitment of NuMA to mitotic centrosomes
See in Reactome
R-HSA-5621575
R-HSA-9634600
R-HSA-9634600
Reactome Name: Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
See in Reactome
|
R-HSA-376176
R-HSA-70326
R-HSA-111997
R-HSA-111996
R-HSA-397014
R-HSA-418594
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-168256
R-HSA-382551
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5358351
R-HSA-1640170
R-HSA-5617833
R-HSA-1280218
R-HSA-1266738
R-HSA-1489509
R-HSA-111933
R-HSA-71387
R-HSA-163359
R-HSA-163359
Reactome Name: Glucagon signaling in metabolic regulation
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-1852241
R-HSA-1852241
Reactome Name: Organelle biogenesis and maintenance
See in Reactome
R-HSA-449147
R-HSA-9675108
R-HSA-69278
R-HSA-8979227
R-HSA-112316
R-HSA-372790
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-69275
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-5576891
R-HSA-556833
R-HSA-174824
R-HSA-174824
Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance
See in Reactome
R-HSA-388396
R-HSA-380287
R-HSA-168249
R-HSA-163685
R-HSA-163685
Reactome Name: Integration of energy metabolism
See in Reactome
R-HSA-445717
R-HSA-453274
R-HSA-68886
R-HSA-70171
R-HSA-8963898
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-112043
R-HSA-112040
R-HSA-73857
R-HSA-111885
R-HSA-109582
R-HSA-194138
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-68877
R-HSA-162582
|
Muscle contraction
Immune System
Transport of small molecules
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Organelle biogenesis and maintenance
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-111919
(
R-HSA-111931;
R-HSA-442720
)
R-HSA-111924
(
R-HSA-111931;
R-HSA-442720
)
R-HSA-111924
Reaction Name: PKA catalytic subunit translocates to the nucleus
See in Reactome
R-HSA-111925
(
R-HSA-111931;
R-HSA-163615;
R-HSA-164378;
R-HSA-180024;
R-HSA-432040;
R-HSA-442720
)
R-HSA-111925
Reaction Name: cAMP induces dissociation of inactive PKA tetramers
See in Reactome
R-HSA-163416
(
R-HSA-163560
)
R-HSA-163416
Reaction Name: hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP
See in Reactome
R-HSA-163418
(
R-HSA-163560
)
R-HSA-163418
Reaction Name: perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP
See in Reactome
R-HSA-163672
(
R-HSA-163358
)
R-HSA-163672
Reaction Name: Phosphorylation of ChREBP at Thr(666) by PKA
See in Reactome
R-HSA-163676
(
R-HSA-163358
)
R-HSA-163676
Reaction Name: Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA
See in Reactome
R-HSA-163773
(
R-HSA-163358;
R-HSA-9634600
)
R-HSA-163773
Reaction Name: Phosphorylation of PF2K-Pase by PKA catalytic subunit
See in Reactome
R-HSA-177275
(
R-HSA-180024
)
R-HSA-177275
Reaction Name: PKA phosphorylates DARPP-32 on Thr34
See in Reactome
R-HSA-177284
(
R-HSA-180024
)
R-HSA-180073
(
R-HSA-180024
)
R-HSA-180073
Reaction Name: DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function
See in Reactome
R-HSA-2574840
(
R-HSA-2565942
)
R-HSA-2574840
Reaction Name: AJUBA facilitates AURKA autophosphorylation
See in Reactome
R-HSA-2574845
(
R-HSA-2565942
)
R-HSA-2574845
Reaction Name: AJUBA binds centrosome-associated AURKA
See in Reactome
R-HSA-265682
(
R-HSA-422356
)
R-HSA-265682
Reaction Name: KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel
See in Reactome
R-HSA-3000310
(
R-HSA-2565942
)
R-HSA-3000319
(
R-HSA-2565942
)
R-HSA-380272
(
R-HSA-380259;
R-HSA-380284
)
R-HSA-380272
Reaction Name: Plk1-mediated phosphorylation of Nlp
See in Reactome
R-HSA-380283
(
R-HSA-380270
)
R-HSA-380283
Reaction Name: Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
See in Reactome
R-HSA-380294
(
R-HSA-380284
)
R-HSA-380294
Reaction Name: Loss of C-Nap-1 from centrosomes
See in Reactome
R-HSA-380303
(
R-HSA-380259;
R-HSA-380284
)
R-HSA-380303
Reaction Name: Dissociation of Phospho-Nlp from the centrosome
See in Reactome
R-HSA-380311
(
R-HSA-380270
)
R-HSA-380311
Reaction Name: Recruitment of Plk1 to centrosomes
See in Reactome
R-HSA-380316
(
R-HSA-380320
)
R-HSA-380316
Reaction Name: Association of NuMA with microtubules
See in Reactome
R-HSA-380455
(
R-HSA-380270
)
R-HSA-380455
Reaction Name: Recruitment of CDK11p58 to the centrosomes
See in Reactome
R-HSA-380508
(
R-HSA-380320
)
R-HSA-380508
Reaction Name: Translocation of NuMA to the centrosomes
See in Reactome
R-HSA-381644
(
R-HSA-381676;
R-HSA-422356
)
R-HSA-381644
Reaction Name: ER calcium channels open in response to activated PKA
See in Reactome
R-HSA-381707
(
R-HSA-381676;
R-HSA-422356
)
R-HSA-381707
Reaction Name: PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP
See in Reactome
R-HSA-381713
(
R-HSA-381676;
R-HSA-422356
)
R-HSA-381713
Reaction Name: Potassium voltage-gated channels close in reponse to PKA
See in Reactome
R-HSA-432232
(
R-HSA-432040
)
R-HSA-432232
Reaction Name: Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)
See in Reactome
R-HSA-5218854
(
R-HSA-4420097
)
R-HSA-5218854
Reaction Name: p-Y420-FYN is phosphorylated on S21
See in Reactome
R-HSA-5610717
(
R-HSA-5610783;
R-HSA-5610787
)
R-HSA-5610720
(
R-HSA-5610785;
R-HSA-5610787
)
R-HSA-5610741
(
R-HSA-5610780;
R-HSA-5610787
)
R-HSA-5610749
(
R-HSA-5610787
)
R-HSA-5610749
Reaction Name: cAMP dissociates PKA, promoting GLI processing
See in Reactome
R-HSA-5617179
(
R-HSA-5578775
)
R-HSA-5617182
(
R-HSA-5578775
)
R-HSA-5617816
(
R-HSA-5620912
)
R-HSA-5617816
Reaction Name: RAB3IP stimulates nucleotide exchange on RAB8A
See in Reactome
R-HSA-5624473
(
R-HSA-5621575
)
R-HSA-5624473
Reaction Name: Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit
See in Reactome
R-HSA-5626220
(
R-HSA-5620912
)
R-HSA-5626220
Reaction Name: C2CD3 binds the mother centriole
See in Reactome
R-HSA-5626223
(
R-HSA-5620912
)
R-HSA-5626223
Reaction Name: C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole
See in Reactome
R-HSA-5626227
(
R-HSA-5620912
)
R-HSA-5626227
Reaction Name: CP110 and CEP97 dissociate from the centriole
See in Reactome
R-HSA-5626228
(
R-HSA-5620912
)
R-HSA-5626228
Reaction Name: The distal appendage proteins recruit TTBK2
See in Reactome
R-HSA-5626681
(
R-HSA-5620912
)
R-HSA-5626681
Reaction Name: Recruitment of transition zone proteins
See in Reactome
R-HSA-5626699
(
R-HSA-5620912
)
R-HSA-5626699
Reaction Name: MARK4 binds ODF2 in the centriole
See in Reactome
R-HSA-5638009
(
R-HSA-5620912
)
R-HSA-5638009
Reaction Name: CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body
See in Reactome
R-HSA-5682101
(
R-HSA-8963896
)
R-HSA-5682101
Reaction Name: PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer
See in Reactome
R-HSA-5687088
(
R-HSA-5687128
)
R-HSA-8853405
(
R-HSA-8854518
)
R-HSA-8853405
Reaction Name: TPX2 binds AURKA at centrosomes
See in Reactome
R-HSA-8853419
(
R-HSA-8854518
)
R-HSA-8853419
Reaction Name: TPX2 promotes AURKA autophosphorylation
See in Reactome
R-HSA-8854908
(
R-HSA-8853659
)
R-HSA-8854908
Reaction Name: PKA phosphorylates RET:GDNF:GFRA dimer
See in Reactome
R-HSA-8951727
(
R-HSA-111931;
R-HSA-163615;
R-HSA-180024;
R-HSA-432040;
R-HSA-442720
)
R-HSA-8986937
(
R-HSA-9022692
)
R-HSA-8986937
Reaction Name: MECP2 is phosphorylated at T308
See in Reactome
R-HSA-8986939
(
R-HSA-9022692
)
R-HSA-8986939
Reaction Name: MECP2 binds the NCoR/SMRT complex
See in Reactome
R-HSA-9010641
(
R-HSA-9010642
)
R-HSA-913451
(
R-HSA-512988
)
R-HSA-913451
Reaction Name: IL3RB is phosphorylated on Ser-585
See in Reactome
R-HSA-913996
(
R-HSA-392517
)
R-HSA-992708
(
R-HSA-983231
)
R-HSA-992708
Reaction Name: Dual-specific AKAPs bind type I and II PKA regulatory subunits
See in Reactome
|
MONDO:0014516 |
PLK4 |
O00444 |
2.7.11.21
|
R-HSA-380270
R-HSA-380270
Reactome Name: Recruitment of mitotic centrosome proteins and complexes
See in Reactome
R-HSA-2565942
R-HSA-2565942
Reactome Name: Regulation of PLK1 Activity at G2/M Transition
See in Reactome
R-HSA-380284
R-HSA-380284
Reactome Name: Loss of proteins required for interphase microtubule organization from the centrosome
See in Reactome
R-HSA-380320
R-HSA-380320
Reactome Name: Recruitment of NuMA to mitotic centrosomes
See in Reactome
R-HSA-5620912
R-HSA-5620912
Reactome Name: Anchoring of the basal body to the plasma membrane
See in Reactome
R-HSA-380259
R-HSA-380259
Reactome Name: Loss of Nlp from mitotic centrosomes
See in Reactome
R-HSA-8854518
|
R-HSA-380287
R-HSA-453274
R-HSA-68877
R-HSA-68886
R-HSA-69278
R-HSA-1640170
R-HSA-5617833
R-HSA-1852241
R-HSA-1852241
Reactome Name: Organelle biogenesis and maintenance
See in Reactome
R-HSA-69275
|
Cell Cycle
Organelle biogenesis and maintenance
|
R-HSA-2574840
(
R-HSA-2565942
)
R-HSA-2574840
Reaction Name: AJUBA facilitates AURKA autophosphorylation
See in Reactome
R-HSA-2574845
(
R-HSA-2565942
)
R-HSA-2574845
Reaction Name: AJUBA binds centrosome-associated AURKA
See in Reactome
R-HSA-3000310
(
R-HSA-2565942
)
R-HSA-3000319
(
R-HSA-2565942
)
R-HSA-380272
(
R-HSA-380259;
R-HSA-380284
)
R-HSA-380272
Reaction Name: Plk1-mediated phosphorylation of Nlp
See in Reactome
R-HSA-380283
(
R-HSA-380270
)
R-HSA-380283
Reaction Name: Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
See in Reactome
R-HSA-380294
(
R-HSA-380284
)
R-HSA-380294
Reaction Name: Loss of C-Nap-1 from centrosomes
See in Reactome
R-HSA-380303
(
R-HSA-380259;
R-HSA-380284
)
R-HSA-380303
Reaction Name: Dissociation of Phospho-Nlp from the centrosome
See in Reactome
R-HSA-380311
(
R-HSA-380270
)
R-HSA-380311
Reaction Name: Recruitment of Plk1 to centrosomes
See in Reactome
R-HSA-380316
(
R-HSA-380320
)
R-HSA-380316
Reaction Name: Association of NuMA with microtubules
See in Reactome
R-HSA-380455
(
R-HSA-380270
)
R-HSA-380455
Reaction Name: Recruitment of CDK11p58 to the centrosomes
See in Reactome
R-HSA-380508
(
R-HSA-380320
)
R-HSA-380508
Reaction Name: Translocation of NuMA to the centrosomes
See in Reactome
R-HSA-5617816
(
R-HSA-5620912
)
R-HSA-5617816
Reaction Name: RAB3IP stimulates nucleotide exchange on RAB8A
See in Reactome
R-HSA-5626220
(
R-HSA-5620912
)
R-HSA-5626220
Reaction Name: C2CD3 binds the mother centriole
See in Reactome
R-HSA-5626223
(
R-HSA-5620912
)
R-HSA-5626223
Reaction Name: C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole
See in Reactome
R-HSA-5626227
(
R-HSA-5620912
)
R-HSA-5626227
Reaction Name: CP110 and CEP97 dissociate from the centriole
See in Reactome
R-HSA-5626228
(
R-HSA-5620912
)
R-HSA-5626228
Reaction Name: The distal appendage proteins recruit TTBK2
See in Reactome
R-HSA-5626681
(
R-HSA-5620912
)
R-HSA-5626681
Reaction Name: Recruitment of transition zone proteins
See in Reactome
R-HSA-5626699
(
R-HSA-5620912
)
R-HSA-5626699
Reaction Name: MARK4 binds ODF2 in the centriole
See in Reactome
R-HSA-5638009
(
R-HSA-5620912
)
R-HSA-5638009
Reaction Name: CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body
See in Reactome
R-HSA-8853405
(
R-HSA-8854518
)
R-HSA-8853405
Reaction Name: TPX2 binds AURKA at centrosomes
See in Reactome
R-HSA-8853419
(
R-HSA-8854518
)
R-HSA-8853419
Reaction Name: TPX2 promotes AURKA autophosphorylation
See in Reactome
|
MONDO:0015802 |
RAB11A |
P62491 |
3.6.5.2
|
R-HSA-8873719
R-HSA-8854214
R-HSA-5620912
R-HSA-5620912
Reactome Name: Anchoring of the basal body to the plasma membrane
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-5620916
R-HSA-5620916
Reactome Name: VxPx cargo-targeting to cilium
See in Reactome
R-HSA-432040
R-HSA-432040
Reactome Name: Vasopressin regulates renal water homeostasis via Aquaporins
See in Reactome
|
R-HSA-1852241
R-HSA-1852241
Reactome Name: Organelle biogenesis and maintenance
See in Reactome
R-HSA-392499
R-HSA-199991
R-HSA-445717
R-HSA-382551
R-HSA-5620920
R-HSA-5620920
Reactome Name: Cargo trafficking to the periciliary membrane
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5617833
R-HSA-9007101
R-HSA-5653656
|
Organelle biogenesis and maintenance
Metabolism of proteins
Transport of small molecules
Vesicle-mediated transport
|
R-HSA-2316352
(
R-HSA-1445148
)
R-HSA-2316352
Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane
See in Reactome
R-HSA-432237
(
R-HSA-432040
)
R-HSA-432237
Reaction Name: Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane
See in Reactome
R-HSA-5617816
(
R-HSA-5620912
)
R-HSA-5617816
Reaction Name: RAB3IP stimulates nucleotide exchange on RAB8A
See in Reactome
R-HSA-5620921
(
R-HSA-5620916
)
R-HSA-5620921
Reaction Name: ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex
See in Reactome
R-HSA-5623513
(
R-HSA-5620916
)
R-HSA-5623513
Reaction Name: ASAP1 stimulates GTPase activity of ARF4
See in Reactome
R-HSA-5623519
(
R-HSA-5620916
)
R-HSA-5623519
Reaction Name: RAB3IP and RAB8A bind to the ciliary targeting complex
See in Reactome
R-HSA-5623521
(
R-HSA-5620916
)
R-HSA-5623521
Reaction Name: RAB3IP stimulates nucleotide exchange on RAB8A
See in Reactome
R-HSA-5623524
(
R-HSA-5620916
)
R-HSA-5623524
Reaction Name: The exocyst complex binds to RAB3IP in the ciliary targeting complex
See in Reactome
R-HSA-5623525
(
R-HSA-5620916
)
R-HSA-5623525
Reaction Name: Cargo-carrying vesicles bud from the TGN
See in Reactome
R-HSA-5623527
(
R-HSA-5620916
)
R-HSA-5623527
Reaction Name: VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane
See in Reactome
R-HSA-5638009
(
R-HSA-5620912
)
R-HSA-5638009
Reaction Name: CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body
See in Reactome
R-HSA-5638014
(
R-HSA-5620912
)
R-HSA-5638014
Reaction Name: RAB11A:GTP-containing Golgi vesicles recruit RAB3IP
See in Reactome
R-HSA-8854759
(
R-HSA-8854214
)
R-HSA-8870466
(
R-HSA-8873719
)
R-HSA-8870469
(
R-HSA-8873719
)
R-HSA-8870469
Reaction Name: RGGT geranylgeranylates RAB proteins
See in Reactome
|
MONDO:0019342 |
MONDO:0019342
Disease Name: Seckel syndrome
OMIM id: OMIM:616777
Orphanet id: Orphanet:808
All associated enzymes in DAR:
PLK4
. The disease is also associated to other non-enzyme proteins (not in DAR).
PLK4 |
O00444 |
2.7.11.21
|
R-HSA-380270
R-HSA-380270
Reactome Name: Recruitment of mitotic centrosome proteins and complexes
See in Reactome
R-HSA-2565942
R-HSA-2565942
Reactome Name: Regulation of PLK1 Activity at G2/M Transition
See in Reactome
R-HSA-380284
R-HSA-380284
Reactome Name: Loss of proteins required for interphase microtubule organization from the centrosome
See in Reactome
R-HSA-380320
R-HSA-380320
Reactome Name: Recruitment of NuMA to mitotic centrosomes
See in Reactome
R-HSA-5620912
R-HSA-5620912
Reactome Name: Anchoring of the basal body to the plasma membrane
See in Reactome
R-HSA-380259
R-HSA-380259
Reactome Name: Loss of Nlp from mitotic centrosomes
See in Reactome
R-HSA-8854518
|
R-HSA-380287
R-HSA-453274
R-HSA-68877
R-HSA-68886
R-HSA-69278
R-HSA-1640170
R-HSA-5617833
R-HSA-1852241
R-HSA-1852241
Reactome Name: Organelle biogenesis and maintenance
See in Reactome
R-HSA-69275
|
Cell Cycle
Organelle biogenesis and maintenance
|
R-HSA-2574840
(
R-HSA-2565942
)
R-HSA-2574840
Reaction Name: AJUBA facilitates AURKA autophosphorylation
See in Reactome
R-HSA-2574845
(
R-HSA-2565942
)
R-HSA-2574845
Reaction Name: AJUBA binds centrosome-associated AURKA
See in Reactome
R-HSA-3000310
(
R-HSA-2565942
)
R-HSA-3000319
(
R-HSA-2565942
)
R-HSA-380272
(
R-HSA-380259;
R-HSA-380284
)
R-HSA-380272
Reaction Name: Plk1-mediated phosphorylation of Nlp
See in Reactome
R-HSA-380283
(
R-HSA-380270
)
R-HSA-380283
Reaction Name: Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
See in Reactome
R-HSA-380294
(
R-HSA-380284
)
R-HSA-380294
Reaction Name: Loss of C-Nap-1 from centrosomes
See in Reactome
R-HSA-380303
(
R-HSA-380259;
R-HSA-380284
)
R-HSA-380303
Reaction Name: Dissociation of Phospho-Nlp from the centrosome
See in Reactome
R-HSA-380311
(
R-HSA-380270
)
R-HSA-380311
Reaction Name: Recruitment of Plk1 to centrosomes
See in Reactome
R-HSA-380316
(
R-HSA-380320
)
R-HSA-380316
Reaction Name: Association of NuMA with microtubules
See in Reactome
R-HSA-380455
(
R-HSA-380270
)
R-HSA-380455
Reaction Name: Recruitment of CDK11p58 to the centrosomes
See in Reactome
R-HSA-380508
(
R-HSA-380320
)
R-HSA-380508
Reaction Name: Translocation of NuMA to the centrosomes
See in Reactome
R-HSA-5617816
(
R-HSA-5620912
)
R-HSA-5617816
Reaction Name: RAB3IP stimulates nucleotide exchange on RAB8A
See in Reactome
R-HSA-5626220
(
R-HSA-5620912
)
R-HSA-5626220
Reaction Name: C2CD3 binds the mother centriole
See in Reactome
R-HSA-5626223
(
R-HSA-5620912
)
R-HSA-5626223
Reaction Name: C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole
See in Reactome
R-HSA-5626227
(
R-HSA-5620912
)
R-HSA-5626227
Reaction Name: CP110 and CEP97 dissociate from the centriole
See in Reactome
R-HSA-5626228
(
R-HSA-5620912
)
R-HSA-5626228
Reaction Name: The distal appendage proteins recruit TTBK2
See in Reactome
R-HSA-5626681
(
R-HSA-5620912
)
R-HSA-5626681
Reaction Name: Recruitment of transition zone proteins
See in Reactome
R-HSA-5626699
(
R-HSA-5620912
)
R-HSA-5626699
Reaction Name: MARK4 binds ODF2 in the centriole
See in Reactome
R-HSA-5638009
(
R-HSA-5620912
)
R-HSA-5638009
Reaction Name: CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body
See in Reactome
R-HSA-8853405
(
R-HSA-8854518
)
R-HSA-8853405
Reaction Name: TPX2 binds AURKA at centrosomes
See in Reactome
R-HSA-8853419
(
R-HSA-8854518
)
R-HSA-8853419
Reaction Name: TPX2 promotes AURKA autophosphorylation
See in Reactome
|
MONDO:0030876 |
PRKACA |
P17612 |
2.7.11.11
|
R-HSA-442720
R-HSA-442720
Reactome Name: CREB1 phosphorylation through the activation of Adenylate Cyclase
See in Reactome
R-HSA-9022692
R-HSA-9022692
Reactome Name: Regulation of MECP2 expression and activity
See in Reactome
R-HSA-381676
R-HSA-381676
Reactome Name: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
See in Reactome
R-HSA-380259
R-HSA-380259
Reactome Name: Loss of Nlp from mitotic centrosomes
See in Reactome
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-432040
R-HSA-432040
Reactome Name: Vasopressin regulates renal water homeostasis via Aquaporins
See in Reactome
R-HSA-380270
R-HSA-380270
Reactome Name: Recruitment of mitotic centrosome proteins and complexes
See in Reactome
R-HSA-5610783
R-HSA-5610783
Reactome Name: Degradation of GLI2 by the proteasome
See in Reactome
R-HSA-111931
R-HSA-111931
Reactome Name: PKA-mediated phosphorylation of CREB
See in Reactome
R-HSA-180024
R-HSA-5610787
R-HSA-163615
R-HSA-5610785
R-HSA-5610785
Reactome Name: GLI3 is processed to GLI3R by the proteasome
See in Reactome
R-HSA-164378
R-HSA-164378
Reactome Name: PKA activation in glucagon signalling
See in Reactome
R-HSA-5578775
R-HSA-8853659
R-HSA-9010642
R-HSA-8854518
R-HSA-4420097
R-HSA-380284
R-HSA-380284
Reactome Name: Loss of proteins required for interphase microtubule organization from the centrosome
See in Reactome
R-HSA-5687128
R-HSA-163560
R-HSA-5610780
R-HSA-5610780
Reactome Name: Degradation of GLI1 by the proteasome
See in Reactome
R-HSA-5620912
R-HSA-5620912
Reactome Name: Anchoring of the basal body to the plasma membrane
See in Reactome
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-8963896
R-HSA-392517
R-HSA-163358
R-HSA-163358
Reactome Name: PKA-mediated phosphorylation of key metabolic factors
See in Reactome
R-HSA-422356
R-HSA-422356
Reactome Name: Regulation of insulin secretion
See in Reactome
R-HSA-2565942
R-HSA-2565942
Reactome Name: Regulation of PLK1 Activity at G2/M Transition
See in Reactome
R-HSA-380320
R-HSA-380320
Reactome Name: Recruitment of NuMA to mitotic centrosomes
See in Reactome
R-HSA-5621575
R-HSA-9634600
R-HSA-9634600
Reactome Name: Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
See in Reactome
|
R-HSA-376176
R-HSA-70326
R-HSA-111997
R-HSA-111996
R-HSA-397014
R-HSA-418594
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-168256
R-HSA-382551
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5358351
R-HSA-1640170
R-HSA-5617833
R-HSA-1280218
R-HSA-1266738
R-HSA-1489509
R-HSA-111933
R-HSA-71387
R-HSA-163359
R-HSA-163359
Reactome Name: Glucagon signaling in metabolic regulation
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-1852241
R-HSA-1852241
Reactome Name: Organelle biogenesis and maintenance
See in Reactome
R-HSA-449147
R-HSA-9675108
R-HSA-69278
R-HSA-8979227
R-HSA-112316
R-HSA-372790
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-69275
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-5576891
R-HSA-556833
R-HSA-174824
R-HSA-174824
Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance
See in Reactome
R-HSA-388396
R-HSA-380287
R-HSA-168249
R-HSA-163685
R-HSA-163685
Reactome Name: Integration of energy metabolism
See in Reactome
R-HSA-445717
R-HSA-453274
R-HSA-68886
R-HSA-70171
R-HSA-8963898
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-112043
R-HSA-112040
R-HSA-73857
R-HSA-111885
R-HSA-109582
R-HSA-194138
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-68877
R-HSA-162582
|
Muscle contraction
Immune System
Transport of small molecules
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Organelle biogenesis and maintenance
Neuronal System
Hemostasis
Signal Transduction
|
R-HSA-111919
(
R-HSA-111931;
R-HSA-442720
)
R-HSA-111924
(
R-HSA-111931;
R-HSA-442720
)
R-HSA-111924
Reaction Name: PKA catalytic subunit translocates to the nucleus
See in Reactome
R-HSA-111925
(
R-HSA-111931;
R-HSA-163615;
R-HSA-164378;
R-HSA-180024;
R-HSA-432040;
R-HSA-442720
)
R-HSA-111925
Reaction Name: cAMP induces dissociation of inactive PKA tetramers
See in Reactome
R-HSA-163416
(
R-HSA-163560
)
R-HSA-163416
Reaction Name: hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP
See in Reactome
R-HSA-163418
(
R-HSA-163560
)
R-HSA-163418
Reaction Name: perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP
See in Reactome
R-HSA-163672
(
R-HSA-163358
)
R-HSA-163672
Reaction Name: Phosphorylation of ChREBP at Thr(666) by PKA
See in Reactome
R-HSA-163676
(
R-HSA-163358
)
R-HSA-163676
Reaction Name: Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA
See in Reactome
R-HSA-163773
(
R-HSA-163358;
R-HSA-9634600
)
R-HSA-163773
Reaction Name: Phosphorylation of PF2K-Pase by PKA catalytic subunit
See in Reactome
R-HSA-177275
(
R-HSA-180024
)
R-HSA-177275
Reaction Name: PKA phosphorylates DARPP-32 on Thr34
See in Reactome
R-HSA-177284
(
R-HSA-180024
)
R-HSA-180073
(
R-HSA-180024
)
R-HSA-180073
Reaction Name: DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function
See in Reactome
R-HSA-2574840
(
R-HSA-2565942
)
R-HSA-2574840
Reaction Name: AJUBA facilitates AURKA autophosphorylation
See in Reactome
R-HSA-2574845
(
R-HSA-2565942
)
R-HSA-2574845
Reaction Name: AJUBA binds centrosome-associated AURKA
See in Reactome
R-HSA-265682
(
R-HSA-422356
)
R-HSA-265682
Reaction Name: KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel
See in Reactome
R-HSA-3000310
(
R-HSA-2565942
)
R-HSA-3000319
(
R-HSA-2565942
)
R-HSA-380272
(
R-HSA-380259;
R-HSA-380284
)
R-HSA-380272
Reaction Name: Plk1-mediated phosphorylation of Nlp
See in Reactome
R-HSA-380283
(
R-HSA-380270
)
R-HSA-380283
Reaction Name: Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
See in Reactome
R-HSA-380294
(
R-HSA-380284
)
R-HSA-380294
Reaction Name: Loss of C-Nap-1 from centrosomes
See in Reactome
R-HSA-380303
(
R-HSA-380259;
R-HSA-380284
)
R-HSA-380303
Reaction Name: Dissociation of Phospho-Nlp from the centrosome
See in Reactome
R-HSA-380311
(
R-HSA-380270
)
R-HSA-380311
Reaction Name: Recruitment of Plk1 to centrosomes
See in Reactome
R-HSA-380316
(
R-HSA-380320
)
R-HSA-380316
Reaction Name: Association of NuMA with microtubules
See in Reactome
R-HSA-380455
(
R-HSA-380270
)
R-HSA-380455
Reaction Name: Recruitment of CDK11p58 to the centrosomes
See in Reactome
R-HSA-380508
(
R-HSA-380320
)
R-HSA-380508
Reaction Name: Translocation of NuMA to the centrosomes
See in Reactome
R-HSA-381644
(
R-HSA-381676;
R-HSA-422356
)
R-HSA-381644
Reaction Name: ER calcium channels open in response to activated PKA
See in Reactome
R-HSA-381707
(
R-HSA-381676;
R-HSA-422356
)
R-HSA-381707
Reaction Name: PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP
See in Reactome
R-HSA-381713
(
R-HSA-381676;
R-HSA-422356
)
R-HSA-381713
Reaction Name: Potassium voltage-gated channels close in reponse to PKA
See in Reactome
R-HSA-432232
(
R-HSA-432040
)
R-HSA-432232
Reaction Name: Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)
See in Reactome
R-HSA-5218854
(
R-HSA-4420097
)
R-HSA-5218854
Reaction Name: p-Y420-FYN is phosphorylated on S21
See in Reactome
R-HSA-5610717
(
R-HSA-5610783;
R-HSA-5610787
)
R-HSA-5610720
(
R-HSA-5610785;
R-HSA-5610787
)
R-HSA-5610741
(
R-HSA-5610780;
R-HSA-5610787
)
R-HSA-5610749
(
R-HSA-5610787
)
R-HSA-5610749
Reaction Name: cAMP dissociates PKA, promoting GLI processing
See in Reactome
R-HSA-5617179
(
R-HSA-5578775
)
R-HSA-5617182
(
R-HSA-5578775
)
R-HSA-5617816
(
R-HSA-5620912
)
R-HSA-5617816
Reaction Name: RAB3IP stimulates nucleotide exchange on RAB8A
See in Reactome
R-HSA-5624473
(
R-HSA-5621575
)
R-HSA-5624473
Reaction Name: Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit
See in Reactome
R-HSA-5626220
(
R-HSA-5620912
)
R-HSA-5626220
Reaction Name: C2CD3 binds the mother centriole
See in Reactome
R-HSA-5626223
(
R-HSA-5620912
)
R-HSA-5626223
Reaction Name: C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole
See in Reactome
R-HSA-5626227
(
R-HSA-5620912
)
R-HSA-5626227
Reaction Name: CP110 and CEP97 dissociate from the centriole
See in Reactome
R-HSA-5626228
(
R-HSA-5620912
)
R-HSA-5626228
Reaction Name: The distal appendage proteins recruit TTBK2
See in Reactome
R-HSA-5626681
(
R-HSA-5620912
)
R-HSA-5626681
Reaction Name: Recruitment of transition zone proteins
See in Reactome
R-HSA-5626699
(
R-HSA-5620912
)
R-HSA-5626699
Reaction Name: MARK4 binds ODF2 in the centriole
See in Reactome
R-HSA-5638009
(
R-HSA-5620912
)
R-HSA-5638009
Reaction Name: CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body
See in Reactome
R-HSA-5682101
(
R-HSA-8963896
)
R-HSA-5682101
Reaction Name: PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer
See in Reactome
R-HSA-5687088
(
R-HSA-5687128
)
R-HSA-8853405
(
R-HSA-8854518
)
R-HSA-8853405
Reaction Name: TPX2 binds AURKA at centrosomes
See in Reactome
R-HSA-8853419
(
R-HSA-8854518
)
R-HSA-8853419
Reaction Name: TPX2 promotes AURKA autophosphorylation
See in Reactome
R-HSA-8854908
(
R-HSA-8853659
)
R-HSA-8854908
Reaction Name: PKA phosphorylates RET:GDNF:GFRA dimer
See in Reactome
R-HSA-8951727
(
R-HSA-111931;
R-HSA-163615;
R-HSA-180024;
R-HSA-432040;
R-HSA-442720
)
R-HSA-8986937
(
R-HSA-9022692
)
R-HSA-8986937
Reaction Name: MECP2 is phosphorylated at T308
See in Reactome
R-HSA-8986939
(
R-HSA-9022692
)
R-HSA-8986939
Reaction Name: MECP2 binds the NCoR/SMRT complex
See in Reactome
R-HSA-9010641
(
R-HSA-9010642
)
R-HSA-913451
(
R-HSA-512988
)
R-HSA-913451
Reaction Name: IL3RB is phosphorylated on Ser-585
See in Reactome
R-HSA-913996
(
R-HSA-392517
)
R-HSA-992708
(
R-HSA-983231
)
R-HSA-992708
Reaction Name: Dual-specific AKAPs bind type I and II PKA regulatory subunits
See in Reactome
|