DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-5610780)

Number of enzymes:	7
Number of disease:	8
Number of reactomes:	85
Number of reactions:	138

Search results (Reactome ID: R-HSA-5610780)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0013245	ITCH	Q96J02	2.3.2.26	R-HSA-5610780 R-HSA-5610780 Reactome Name: Degradation of GLI1 by the proteasome See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-5632684 R-HSA-5632684 Reactome Name: Hedgehog 'on' state See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-8939236 R-HSA-8939236 Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs See in Reactome R-HSA-1253288 R-HSA-1253288 Reactome Name: Downregulation of ERBB4 signaling See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome	R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Signal Transduction	R-HSA-1253282 ( R-HSA-1253288 ) R-HSA-1253282 Reaction Name: ERBB4 ubiquitination by WWP1/ITCH See in Reactome R-HSA-1253300 ( R-HSA-1253288 ) R-HSA-1253300 Reaction Name: ERBB4 binds WWP1/ITCH ubiquitin ligases See in Reactome R-HSA-1912357 ( R-HSA-2122948 ) R-HSA-1912357 Reaction Name: ITCH ubiquitinates DTX See in Reactome R-HSA-1912386 ( R-HSA-2122948 ) R-HSA-1912386 Reaction Name: Ubiquitination of NOTCH1 by ITCH in the absence of ligand See in Reactome R-HSA-1980125 ( R-HSA-2122948 ) R-HSA-1980125 Reaction Name: ITCH binds DTX See in Reactome R-HSA-1980128 ( R-HSA-2122948 ) R-HSA-1980128 Reaction Name: NOTCH1 associates with negative regulators NUMB and ITCH See in Reactome R-HSA-5610735 ( R-HSA-5610780; R-HSA-5632684 ) R-HSA-5610735 Reaction Name: NUMB binds ITCH See in Reactome R-HSA-5610737 ( R-HSA-5610780 ) R-HSA-5610737 Reaction Name: NUMB:ITCH bind and ubiquitnate GLI1 See in Reactome R-HSA-5610760 ( R-HSA-5610780 ) R-HSA-5610760 Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by ITCH See in Reactome R-HSA-5635861 ( R-HSA-5632684 ) R-HSA-5635861 Reaction Name: NUMB:ITCH binds GLI1 See in Reactome R-HSA-5635864 ( R-HSA-5632684 ) R-HSA-5635864 Reaction Name: NUMB:ITCH ubiquitinates GLI1 See in Reactome R-HSA-5635868 ( R-HSA-5632684 ) R-HSA-5635868 Reaction Name: ub-GLI is degraded by the proteasome See in Reactome R-HSA-688137 ( R-HSA-168638 ) R-HSA-688137 Reaction Name: RIP2 is K63 polyubiquitinated See in Reactome R-HSA-8956652 ( R-HSA-8939236 ) R-HSA-8956652 Reaction Name: ITCH gene expression is stimulated by RUNX1 and YAP1 See in Reactome R-HSA-8956684 ( R-HSA-8939236 ) R-HSA-8956684 Reaction Name: ITCH polyubiquitinates TP73 See in Reactome R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome R-HSA-990526 ( R-HSA-936440 ) R-HSA-990526 Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS See in Reactome
MONDO:0014359	PRKACA	P17612	2.7.11.11	R-HSA-442720 R-HSA-442720 Reactome Name: CREB1 phosphorylation through the activation of Adenylate Cyclase See in Reactome R-HSA-9022692 R-HSA-9022692 Reactome Name: Regulation of MECP2 expression and activity See in Reactome R-HSA-381676 R-HSA-381676 Reactome Name: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion See in Reactome R-HSA-380259 R-HSA-380259 Reactome Name: Loss of Nlp from mitotic centrosomes See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-432040 R-HSA-432040 Reactome Name: Vasopressin regulates renal water homeostasis via Aquaporins See in Reactome R-HSA-380270 R-HSA-380270 Reactome Name: Recruitment of mitotic centrosome proteins and complexes See in Reactome R-HSA-5610783 R-HSA-5610783 Reactome Name: Degradation of GLI2 by the proteasome See in Reactome R-HSA-111931 R-HSA-111931 Reactome Name: PKA-mediated phosphorylation of CREB See in Reactome R-HSA-180024 R-HSA-180024 Reactome Name: DARPP-32 events See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-163615 R-HSA-163615 Reactome Name: PKA activation See in Reactome R-HSA-5610785 R-HSA-5610785 Reactome Name: GLI3 is processed to GLI3R by the proteasome See in Reactome R-HSA-164378 R-HSA-164378 Reactome Name: PKA activation in glucagon signalling See in Reactome R-HSA-5578775 R-HSA-5578775 Reactome Name: Ion homeostasis See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9010642 R-HSA-9010642 Reactome Name: ROBO receptors bind AKAP5 See in Reactome R-HSA-8854518 R-HSA-8854518 Reactome Name: AURKA Activation by TPX2 See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-380284 R-HSA-380284 Reactome Name: Loss of proteins required for interphase microtubule organization from the centrosome See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-163560 R-HSA-163560 Reactome Name: Triglyceride catabolism See in Reactome R-HSA-5610780 R-HSA-5610780 Reactome Name: Degradation of GLI1 by the proteasome See in Reactome R-HSA-5620912 R-HSA-5620912 Reactome Name: Anchoring of the basal body to the plasma membrane See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-8963896 R-HSA-8963896 Reactome Name: HDL assembly See in Reactome R-HSA-392517 R-HSA-392517 Reactome Name: Rap1 signalling See in Reactome R-HSA-163358 R-HSA-163358 Reactome Name: PKA-mediated phosphorylation of key metabolic factors See in Reactome R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome R-HSA-2565942 R-HSA-2565942 Reactome Name: Regulation of PLK1 Activity at G2/M Transition See in Reactome R-HSA-380320 R-HSA-380320 Reactome Name: Recruitment of NuMA to mitotic centrosomes See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9634600 R-HSA-9634600 Reactome Name: Regulation of glycolysis by fructose 2,6-bisphosphate metabolism See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5617833 R-HSA-5617833 Reactome Name: Cilium Assembly See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-163359 R-HSA-163359 Reactome Name: Glucagon signaling in metabolic regulation See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-8979227 R-HSA-8979227 Reactome Name: Triglyceride metabolism See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-5576891 R-HSA-5576891 Reactome Name: Cardiac conduction See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-380287 R-HSA-380287 Reactome Name: Centrosome maturation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-445717 R-HSA-445717 Reactome Name: Aquaporin-mediated transport See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-8963898 R-HSA-8963898 Reactome Name: Plasma lipoprotein assembly See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-68877 R-HSA-68877 Reactome Name: Mitotic Prometaphase See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Muscle contraction Immune System Transport of small molecules Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Organelle biogenesis and maintenance Neuronal System Hemostasis Signal Transduction	R-HSA-111919 ( R-HSA-111931; R-HSA-442720 ) R-HSA-111919 Reaction Name: PKA phosphorylates CREB1 See in Reactome R-HSA-111924 ( R-HSA-111931; R-HSA-442720 ) R-HSA-111924 Reaction Name: PKA catalytic subunit translocates to the nucleus See in Reactome R-HSA-111925 ( R-HSA-111931; R-HSA-163615; R-HSA-164378; R-HSA-180024; R-HSA-432040; R-HSA-442720 ) R-HSA-111925 Reaction Name: cAMP induces dissociation of inactive PKA tetramers See in Reactome R-HSA-163416 ( R-HSA-163560 ) R-HSA-163416 Reaction Name: hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP See in Reactome R-HSA-163418 ( R-HSA-163560 ) R-HSA-163418 Reaction Name: perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP See in Reactome R-HSA-163672 ( R-HSA-163358 ) R-HSA-163672 Reaction Name: Phosphorylation of ChREBP at Thr(666) by PKA See in Reactome R-HSA-163676 ( R-HSA-163358 ) R-HSA-163676 Reaction Name: Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA See in Reactome R-HSA-163773 ( R-HSA-163358; R-HSA-9634600 ) R-HSA-163773 Reaction Name: Phosphorylation of PF2K-Pase by PKA catalytic subunit See in Reactome R-HSA-177275 ( R-HSA-180024 ) R-HSA-177275 Reaction Name: PKA phosphorylates DARPP-32 on Thr34 See in Reactome R-HSA-177284 ( R-HSA-180024 ) R-HSA-177284 Reaction Name: PKA phosphorylates PDE4B See in Reactome R-HSA-180073 ( R-HSA-180024 ) R-HSA-180073 Reaction Name: DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function See in Reactome R-HSA-2574840 ( R-HSA-2565942 ) R-HSA-2574840 Reaction Name: AJUBA facilitates AURKA autophosphorylation See in Reactome R-HSA-2574845 ( R-HSA-2565942 ) R-HSA-2574845 Reaction Name: AJUBA binds centrosome-associated AURKA See in Reactome R-HSA-265682 ( R-HSA-422356 ) R-HSA-265682 Reaction Name: KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel See in Reactome R-HSA-3000310 ( R-HSA-2565942 ) R-HSA-3000310 Reaction Name: AURKA phosphorylates PLK1 See in Reactome R-HSA-3000319 ( R-HSA-2565942 ) R-HSA-3000319 Reaction Name: BORA binds PLK1 and AURKA See in Reactome R-HSA-380272 ( R-HSA-380259; R-HSA-380284 ) R-HSA-380272 Reaction Name: Plk1-mediated phosphorylation of Nlp See in Reactome R-HSA-380283 ( R-HSA-380270 ) R-HSA-380283 Reaction Name: Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome See in Reactome R-HSA-380294 ( R-HSA-380284 ) R-HSA-380294 Reaction Name: Loss of C-Nap-1 from centrosomes See in Reactome R-HSA-380303 ( R-HSA-380259; R-HSA-380284 ) R-HSA-380303 Reaction Name: Dissociation of Phospho-Nlp from the centrosome See in Reactome R-HSA-380311 ( R-HSA-380270 ) R-HSA-380311 Reaction Name: Recruitment of Plk1 to centrosomes See in Reactome R-HSA-380316 ( R-HSA-380320 ) R-HSA-380316 Reaction Name: Association of NuMA with microtubules See in Reactome R-HSA-380455 ( R-HSA-380270 ) R-HSA-380455 Reaction Name: Recruitment of CDK11p58 to the centrosomes See in Reactome R-HSA-380508 ( R-HSA-380320 ) R-HSA-380508 Reaction Name: Translocation of NuMA to the centrosomes See in Reactome R-HSA-381644 ( R-HSA-381676; R-HSA-422356 ) R-HSA-381644 Reaction Name: ER calcium channels open in response to activated PKA See in Reactome R-HSA-381707 ( R-HSA-381676; R-HSA-422356 ) R-HSA-381707 Reaction Name: PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP See in Reactome R-HSA-381713 ( R-HSA-381676; R-HSA-422356 ) R-HSA-381713 Reaction Name: Potassium voltage-gated channels close in reponse to PKA See in Reactome R-HSA-432232 ( R-HSA-432040 ) R-HSA-432232 Reaction Name: Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) See in Reactome R-HSA-5218854 ( R-HSA-4420097 ) R-HSA-5218854 Reaction Name: p-Y420-FYN is phosphorylated on S21 See in Reactome R-HSA-5610717 ( R-HSA-5610783; R-HSA-5610787 ) R-HSA-5610717 Reaction Name: PKA phosphorylates GLI2 See in Reactome R-HSA-5610720 ( R-HSA-5610785; R-HSA-5610787 ) R-HSA-5610720 Reaction Name: PKA phosphorylates GLI3 See in Reactome R-HSA-5610741 ( R-HSA-5610780; R-HSA-5610787 ) R-HSA-5610741 Reaction Name: PKA phosphorylates GLI1 See in Reactome R-HSA-5610749 ( R-HSA-5610787 ) R-HSA-5610749 Reaction Name: cAMP dissociates PKA, promoting GLI processing See in Reactome R-HSA-5617179 ( R-HSA-5578775 ) R-HSA-5617179 Reaction Name: PRKACA phosphorylates TNNI3 See in Reactome R-HSA-5617182 ( R-HSA-5578775 ) R-HSA-5617182 Reaction Name: PRKACA phosphorylates PLN See in Reactome R-HSA-5617816 ( R-HSA-5620912 ) R-HSA-5617816 Reaction Name: RAB3IP stimulates nucleotide exchange on RAB8A See in Reactome R-HSA-5624473 ( R-HSA-5621575 ) R-HSA-5624473 Reaction Name: Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit See in Reactome R-HSA-5626220 ( R-HSA-5620912 ) R-HSA-5626220 Reaction Name: C2CD3 binds the mother centriole See in Reactome R-HSA-5626223 ( R-HSA-5620912 ) R-HSA-5626223 Reaction Name: C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole See in Reactome R-HSA-5626227 ( R-HSA-5620912 ) R-HSA-5626227 Reaction Name: CP110 and CEP97 dissociate from the centriole See in Reactome R-HSA-5626228 ( R-HSA-5620912 ) R-HSA-5626228 Reaction Name: The distal appendage proteins recruit TTBK2 See in Reactome R-HSA-5626681 ( R-HSA-5620912 ) R-HSA-5626681 Reaction Name: Recruitment of transition zone proteins See in Reactome R-HSA-5626699 ( R-HSA-5620912 ) R-HSA-5626699 Reaction Name: MARK4 binds ODF2 in the centriole See in Reactome R-HSA-5638009 ( R-HSA-5620912 ) R-HSA-5638009 Reaction Name: CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body See in Reactome R-HSA-5682101 ( R-HSA-8963896 ) R-HSA-5682101 Reaction Name: PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer See in Reactome R-HSA-5687088 ( R-HSA-5687128 ) R-HSA-5687088 Reaction Name: PKA phosphorylates MAPKAPK5 See in Reactome R-HSA-8853405 ( R-HSA-8854518 ) R-HSA-8853405 Reaction Name: TPX2 binds AURKA at centrosomes See in Reactome R-HSA-8853419 ( R-HSA-8854518 ) R-HSA-8853419 Reaction Name: TPX2 promotes AURKA autophosphorylation See in Reactome R-HSA-8854908 ( R-HSA-8853659 ) R-HSA-8854908 Reaction Name: PKA phosphorylates RET:GDNF:GFRA dimer See in Reactome R-HSA-8951727 ( R-HSA-111931; R-HSA-163615; R-HSA-180024; R-HSA-432040; R-HSA-442720 ) R-HSA-8951727 Reaction Name: cAMP binds PKA tetramer See in Reactome R-HSA-8986937 ( R-HSA-9022692 ) R-HSA-8986937 Reaction Name: MECP2 is phosphorylated at T308 See in Reactome R-HSA-8986939 ( R-HSA-9022692 ) R-HSA-8986939 Reaction Name: MECP2 binds the NCoR/SMRT complex See in Reactome R-HSA-9010641 ( R-HSA-9010642 ) R-HSA-9010641 Reaction Name: AKAP5 recruits PKA to ROBO2 See in Reactome R-HSA-913451 ( R-HSA-512988 ) R-HSA-913451 Reaction Name: IL3RB is phosphorylated on Ser-585 See in Reactome R-HSA-913996 ( R-HSA-392517 ) R-HSA-913996 Reaction Name: PKA/PKG phosphorylate Rap1GAP2 See in Reactome R-HSA-992708 ( R-HSA-983231 ) R-HSA-992708 Reaction Name: Dual-specific AKAPs bind type I and II PKA regulatory subunits See in Reactome
MONDO:0014518	PRKACG	P22612	2.7.11.11	R-HSA-442720 R-HSA-442720 Reactome Name: CREB1 phosphorylation through the activation of Adenylate Cyclase See in Reactome R-HSA-381676 R-HSA-381676 Reactome Name: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-432040 R-HSA-432040 Reactome Name: Vasopressin regulates renal water homeostasis via Aquaporins See in Reactome R-HSA-5610783 R-HSA-5610783 Reactome Name: Degradation of GLI2 by the proteasome See in Reactome R-HSA-111931 R-HSA-111931 Reactome Name: PKA-mediated phosphorylation of CREB See in Reactome R-HSA-180024 R-HSA-180024 Reactome Name: DARPP-32 events See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-163615 R-HSA-163615 Reactome Name: PKA activation See in Reactome R-HSA-5610785 R-HSA-5610785 Reactome Name: GLI3 is processed to GLI3R by the proteasome See in Reactome R-HSA-164378 R-HSA-164378 Reactome Name: PKA activation in glucagon signalling See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9010642 R-HSA-9010642 Reactome Name: ROBO receptors bind AKAP5 See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9634600 R-HSA-9634600 Reactome Name: Regulation of glycolysis by fructose 2,6-bisphosphate metabolism See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-163560 R-HSA-163560 Reactome Name: Triglyceride catabolism See in Reactome R-HSA-5610780 R-HSA-5610780 Reactome Name: Degradation of GLI1 by the proteasome See in Reactome R-HSA-8963896 R-HSA-8963896 Reactome Name: HDL assembly See in Reactome R-HSA-392517 R-HSA-392517 Reactome Name: Rap1 signalling See in Reactome R-HSA-163358 R-HSA-163358 Reactome Name: PKA-mediated phosphorylation of key metabolic factors See in Reactome R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-8979227 R-HSA-8979227 Reactome Name: Triglyceride metabolism See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-445717 R-HSA-445717 Reactome Name: Aquaporin-mediated transport See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-8963898 R-HSA-8963898 Reactome Name: Plasma lipoprotein assembly See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-163359 R-HSA-163359 Reactome Name: Glucagon signaling in metabolic regulation See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Transport of small molecules Metabolism Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-111919 ( R-HSA-111931; R-HSA-442720 ) R-HSA-111919 Reaction Name: PKA phosphorylates CREB1 See in Reactome R-HSA-111924 ( R-HSA-111931; R-HSA-442720 ) R-HSA-111924 Reaction Name: PKA catalytic subunit translocates to the nucleus See in Reactome R-HSA-111925 ( R-HSA-111931; R-HSA-163615; R-HSA-164378; R-HSA-180024; R-HSA-432040; R-HSA-442720 ) R-HSA-111925 Reaction Name: cAMP induces dissociation of inactive PKA tetramers See in Reactome R-HSA-163416 ( R-HSA-163560 ) R-HSA-163416 Reaction Name: hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP See in Reactome R-HSA-163418 ( R-HSA-163560 ) R-HSA-163418 Reaction Name: perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP See in Reactome R-HSA-163672 ( R-HSA-163358 ) R-HSA-163672 Reaction Name: Phosphorylation of ChREBP at Thr(666) by PKA See in Reactome R-HSA-163676 ( R-HSA-163358 ) R-HSA-163676 Reaction Name: Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA See in Reactome R-HSA-163773 ( R-HSA-163358; R-HSA-9634600 ) R-HSA-163773 Reaction Name: Phosphorylation of PF2K-Pase by PKA catalytic subunit See in Reactome R-HSA-177275 ( R-HSA-180024 ) R-HSA-177275 Reaction Name: PKA phosphorylates DARPP-32 on Thr34 See in Reactome R-HSA-177284 ( R-HSA-180024 ) R-HSA-177284 Reaction Name: PKA phosphorylates PDE4B See in Reactome R-HSA-265682 ( R-HSA-422356 ) R-HSA-265682 Reaction Name: KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel See in Reactome R-HSA-381644 ( R-HSA-381676; R-HSA-422356 ) R-HSA-381644 Reaction Name: ER calcium channels open in response to activated PKA See in Reactome R-HSA-381707 ( R-HSA-381676; R-HSA-422356 ) R-HSA-381707 Reaction Name: PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP See in Reactome R-HSA-381713 ( R-HSA-381676; R-HSA-422356 ) R-HSA-381713 Reaction Name: Potassium voltage-gated channels close in reponse to PKA See in Reactome R-HSA-432232 ( R-HSA-432040 ) R-HSA-432232 Reaction Name: Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) See in Reactome R-HSA-5218854 ( R-HSA-4420097 ) R-HSA-5218854 Reaction Name: p-Y420-FYN is phosphorylated on S21 See in Reactome R-HSA-5610717 ( R-HSA-5610783; R-HSA-5610787 ) R-HSA-5610717 Reaction Name: PKA phosphorylates GLI2 See in Reactome R-HSA-5610720 ( R-HSA-5610785; R-HSA-5610787 ) R-HSA-5610720 Reaction Name: PKA phosphorylates GLI3 See in Reactome R-HSA-5610741 ( R-HSA-5610780; R-HSA-5610787 ) R-HSA-5610741 Reaction Name: PKA phosphorylates GLI1 See in Reactome R-HSA-5610749 ( R-HSA-5610787 ) R-HSA-5610749 Reaction Name: cAMP dissociates PKA, promoting GLI processing See in Reactome R-HSA-5624473 ( R-HSA-5621575 ) R-HSA-5624473 Reaction Name: Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit See in Reactome R-HSA-5682101 ( R-HSA-8963896 ) R-HSA-5682101 Reaction Name: PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer See in Reactome R-HSA-5687088 ( R-HSA-5687128 ) R-HSA-5687088 Reaction Name: PKA phosphorylates MAPKAPK5 See in Reactome R-HSA-8854908 ( R-HSA-8853659 ) R-HSA-8854908 Reaction Name: PKA phosphorylates RET:GDNF:GFRA dimer See in Reactome R-HSA-8951727 ( R-HSA-111931; R-HSA-163615; R-HSA-180024; R-HSA-432040; R-HSA-442720 ) R-HSA-8951727 Reaction Name: cAMP binds PKA tetramer See in Reactome R-HSA-9010641 ( R-HSA-9010642 ) R-HSA-9010641 Reaction Name: AKAP5 recruits PKA to ROBO2 See in Reactome R-HSA-913996 ( R-HSA-392517 ) R-HSA-913996 Reaction Name: PKA/PKG phosphorylate Rap1GAP2 See in Reactome R-HSA-992708 ( R-HSA-983231 ) R-HSA-992708 Reaction Name: Dual-specific AKAPs bind type I and II PKA regulatory subunits See in Reactome
MONDO:0030876	PRKACA	P17612	2.7.11.11	R-HSA-442720 R-HSA-442720 Reactome Name: CREB1 phosphorylation through the activation of Adenylate Cyclase See in Reactome R-HSA-9022692 R-HSA-9022692 Reactome Name: Regulation of MECP2 expression and activity See in Reactome R-HSA-381676 R-HSA-381676 Reactome Name: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion See in Reactome R-HSA-380259 R-HSA-380259 Reactome Name: Loss of Nlp from mitotic centrosomes See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-432040 R-HSA-432040 Reactome Name: Vasopressin regulates renal water homeostasis via Aquaporins See in Reactome R-HSA-380270 R-HSA-380270 Reactome Name: Recruitment of mitotic centrosome proteins and complexes See in Reactome R-HSA-5610783 R-HSA-5610783 Reactome Name: Degradation of GLI2 by the proteasome See in Reactome R-HSA-111931 R-HSA-111931 Reactome Name: PKA-mediated phosphorylation of CREB See in Reactome R-HSA-180024 R-HSA-180024 Reactome Name: DARPP-32 events See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-163615 R-HSA-163615 Reactome Name: PKA activation See in Reactome R-HSA-5610785 R-HSA-5610785 Reactome Name: GLI3 is processed to GLI3R by the proteasome See in Reactome R-HSA-164378 R-HSA-164378 Reactome Name: PKA activation in glucagon signalling See in Reactome R-HSA-5578775 R-HSA-5578775 Reactome Name: Ion homeostasis See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9010642 R-HSA-9010642 Reactome Name: ROBO receptors bind AKAP5 See in Reactome R-HSA-8854518 R-HSA-8854518 Reactome Name: AURKA Activation by TPX2 See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-380284 R-HSA-380284 Reactome Name: Loss of proteins required for interphase microtubule organization from the centrosome See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-163560 R-HSA-163560 Reactome Name: Triglyceride catabolism See in Reactome R-HSA-5610780 R-HSA-5610780 Reactome Name: Degradation of GLI1 by the proteasome See in Reactome R-HSA-5620912 R-HSA-5620912 Reactome Name: Anchoring of the basal body to the plasma membrane See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-8963896 R-HSA-8963896 Reactome Name: HDL assembly See in Reactome R-HSA-392517 R-HSA-392517 Reactome Name: Rap1 signalling See in Reactome R-HSA-163358 R-HSA-163358 Reactome Name: PKA-mediated phosphorylation of key metabolic factors See in Reactome R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome R-HSA-2565942 R-HSA-2565942 Reactome Name: Regulation of PLK1 Activity at G2/M Transition See in Reactome R-HSA-380320 R-HSA-380320 Reactome Name: Recruitment of NuMA to mitotic centrosomes See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9634600 R-HSA-9634600 Reactome Name: Regulation of glycolysis by fructose 2,6-bisphosphate metabolism See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5617833 R-HSA-5617833 Reactome Name: Cilium Assembly See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-163359 R-HSA-163359 Reactome Name: Glucagon signaling in metabolic regulation See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-8979227 R-HSA-8979227 Reactome Name: Triglyceride metabolism See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-5576891 R-HSA-5576891 Reactome Name: Cardiac conduction See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-380287 R-HSA-380287 Reactome Name: Centrosome maturation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-445717 R-HSA-445717 Reactome Name: Aquaporin-mediated transport See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-8963898 R-HSA-8963898 Reactome Name: Plasma lipoprotein assembly See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-68877 R-HSA-68877 Reactome Name: Mitotic Prometaphase See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Muscle contraction Immune System Transport of small molecules Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Organelle biogenesis and maintenance Neuronal System Hemostasis Signal Transduction	R-HSA-111919 ( R-HSA-111931; R-HSA-442720 ) R-HSA-111919 Reaction Name: PKA phosphorylates CREB1 See in Reactome R-HSA-111924 ( R-HSA-111931; R-HSA-442720 ) R-HSA-111924 Reaction Name: PKA catalytic subunit translocates to the nucleus See in Reactome R-HSA-111925 ( R-HSA-111931; R-HSA-163615; R-HSA-164378; R-HSA-180024; R-HSA-432040; R-HSA-442720 ) R-HSA-111925 Reaction Name: cAMP induces dissociation of inactive PKA tetramers See in Reactome R-HSA-163416 ( R-HSA-163560 ) R-HSA-163416 Reaction Name: hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP See in Reactome R-HSA-163418 ( R-HSA-163560 ) R-HSA-163418 Reaction Name: perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP See in Reactome R-HSA-163672 ( R-HSA-163358 ) R-HSA-163672 Reaction Name: Phosphorylation of ChREBP at Thr(666) by PKA See in Reactome R-HSA-163676 ( R-HSA-163358 ) R-HSA-163676 Reaction Name: Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA See in Reactome R-HSA-163773 ( R-HSA-163358; R-HSA-9634600 ) R-HSA-163773 Reaction Name: Phosphorylation of PF2K-Pase by PKA catalytic subunit See in Reactome R-HSA-177275 ( R-HSA-180024 ) R-HSA-177275 Reaction Name: PKA phosphorylates DARPP-32 on Thr34 See in Reactome R-HSA-177284 ( R-HSA-180024 ) R-HSA-177284 Reaction Name: PKA phosphorylates PDE4B See in Reactome R-HSA-180073 ( R-HSA-180024 ) R-HSA-180073 Reaction Name: DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function See in Reactome R-HSA-2574840 ( R-HSA-2565942 ) R-HSA-2574840 Reaction Name: AJUBA facilitates AURKA autophosphorylation See in Reactome R-HSA-2574845 ( R-HSA-2565942 ) R-HSA-2574845 Reaction Name: AJUBA binds centrosome-associated AURKA See in Reactome R-HSA-265682 ( R-HSA-422356 ) R-HSA-265682 Reaction Name: KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel See in Reactome R-HSA-3000310 ( R-HSA-2565942 ) R-HSA-3000310 Reaction Name: AURKA phosphorylates PLK1 See in Reactome R-HSA-3000319 ( R-HSA-2565942 ) R-HSA-3000319 Reaction Name: BORA binds PLK1 and AURKA See in Reactome R-HSA-380272 ( R-HSA-380259; R-HSA-380284 ) R-HSA-380272 Reaction Name: Plk1-mediated phosphorylation of Nlp See in Reactome R-HSA-380283 ( R-HSA-380270 ) R-HSA-380283 Reaction Name: Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome See in Reactome R-HSA-380294 ( R-HSA-380284 ) R-HSA-380294 Reaction Name: Loss of C-Nap-1 from centrosomes See in Reactome R-HSA-380303 ( R-HSA-380259; R-HSA-380284 ) R-HSA-380303 Reaction Name: Dissociation of Phospho-Nlp from the centrosome See in Reactome R-HSA-380311 ( R-HSA-380270 ) R-HSA-380311 Reaction Name: Recruitment of Plk1 to centrosomes See in Reactome R-HSA-380316 ( R-HSA-380320 ) R-HSA-380316 Reaction Name: Association of NuMA with microtubules See in Reactome R-HSA-380455 ( R-HSA-380270 ) R-HSA-380455 Reaction Name: Recruitment of CDK11p58 to the centrosomes See in Reactome R-HSA-380508 ( R-HSA-380320 ) R-HSA-380508 Reaction Name: Translocation of NuMA to the centrosomes See in Reactome R-HSA-381644 ( R-HSA-381676; R-HSA-422356 ) R-HSA-381644 Reaction Name: ER calcium channels open in response to activated PKA See in Reactome R-HSA-381707 ( R-HSA-381676; R-HSA-422356 ) R-HSA-381707 Reaction Name: PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP See in Reactome R-HSA-381713 ( R-HSA-381676; R-HSA-422356 ) R-HSA-381713 Reaction Name: Potassium voltage-gated channels close in reponse to PKA See in Reactome R-HSA-432232 ( R-HSA-432040 ) R-HSA-432232 Reaction Name: Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) See in Reactome R-HSA-5218854 ( R-HSA-4420097 ) R-HSA-5218854 Reaction Name: p-Y420-FYN is phosphorylated on S21 See in Reactome R-HSA-5610717 ( R-HSA-5610783; R-HSA-5610787 ) R-HSA-5610717 Reaction Name: PKA phosphorylates GLI2 See in Reactome R-HSA-5610720 ( R-HSA-5610785; R-HSA-5610787 ) R-HSA-5610720 Reaction Name: PKA phosphorylates GLI3 See in Reactome R-HSA-5610741 ( R-HSA-5610780; R-HSA-5610787 ) R-HSA-5610741 Reaction Name: PKA phosphorylates GLI1 See in Reactome R-HSA-5610749 ( R-HSA-5610787 ) R-HSA-5610749 Reaction Name: cAMP dissociates PKA, promoting GLI processing See in Reactome R-HSA-5617179 ( R-HSA-5578775 ) R-HSA-5617179 Reaction Name: PRKACA phosphorylates TNNI3 See in Reactome R-HSA-5617182 ( R-HSA-5578775 ) R-HSA-5617182 Reaction Name: PRKACA phosphorylates PLN See in Reactome R-HSA-5617816 ( R-HSA-5620912 ) R-HSA-5617816 Reaction Name: RAB3IP stimulates nucleotide exchange on RAB8A See in Reactome R-HSA-5624473 ( R-HSA-5621575 ) R-HSA-5624473 Reaction Name: Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit See in Reactome R-HSA-5626220 ( R-HSA-5620912 ) R-HSA-5626220 Reaction Name: C2CD3 binds the mother centriole See in Reactome R-HSA-5626223 ( R-HSA-5620912 ) R-HSA-5626223 Reaction Name: C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole See in Reactome R-HSA-5626227 ( R-HSA-5620912 ) R-HSA-5626227 Reaction Name: CP110 and CEP97 dissociate from the centriole See in Reactome R-HSA-5626228 ( R-HSA-5620912 ) R-HSA-5626228 Reaction Name: The distal appendage proteins recruit TTBK2 See in Reactome R-HSA-5626681 ( R-HSA-5620912 ) R-HSA-5626681 Reaction Name: Recruitment of transition zone proteins See in Reactome R-HSA-5626699 ( R-HSA-5620912 ) R-HSA-5626699 Reaction Name: MARK4 binds ODF2 in the centriole See in Reactome R-HSA-5638009 ( R-HSA-5620912 ) R-HSA-5638009 Reaction Name: CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body See in Reactome R-HSA-5682101 ( R-HSA-8963896 ) R-HSA-5682101 Reaction Name: PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer See in Reactome R-HSA-5687088 ( R-HSA-5687128 ) R-HSA-5687088 Reaction Name: PKA phosphorylates MAPKAPK5 See in Reactome R-HSA-8853405 ( R-HSA-8854518 ) R-HSA-8853405 Reaction Name: TPX2 binds AURKA at centrosomes See in Reactome R-HSA-8853419 ( R-HSA-8854518 ) R-HSA-8853419 Reaction Name: TPX2 promotes AURKA autophosphorylation See in Reactome R-HSA-8854908 ( R-HSA-8853659 ) R-HSA-8854908 Reaction Name: PKA phosphorylates RET:GDNF:GFRA dimer See in Reactome R-HSA-8951727 ( R-HSA-111931; R-HSA-163615; R-HSA-180024; R-HSA-432040; R-HSA-442720 ) R-HSA-8951727 Reaction Name: cAMP binds PKA tetramer See in Reactome R-HSA-8986937 ( R-HSA-9022692 ) R-HSA-8986937 Reaction Name: MECP2 is phosphorylated at T308 See in Reactome R-HSA-8986939 ( R-HSA-9022692 ) R-HSA-8986939 Reaction Name: MECP2 binds the NCoR/SMRT complex See in Reactome R-HSA-9010641 ( R-HSA-9010642 ) R-HSA-9010641 Reaction Name: AKAP5 recruits PKA to ROBO2 See in Reactome R-HSA-913451 ( R-HSA-512988 ) R-HSA-913451 Reaction Name: IL3RB is phosphorylated on Ser-585 See in Reactome R-HSA-913996 ( R-HSA-392517 ) R-HSA-913996 Reaction Name: PKA/PKG phosphorylate Rap1GAP2 See in Reactome R-HSA-992708 ( R-HSA-983231 ) R-HSA-992708 Reaction Name: Dual-specific AKAPs bind type I and II PKA regulatory subunits See in Reactome
MONDO:0030877	PRKACB	P22694	2.7.11.11	R-HSA-442720 R-HSA-442720 Reactome Name: CREB1 phosphorylation through the activation of Adenylate Cyclase See in Reactome R-HSA-381676 R-HSA-381676 Reactome Name: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-432040 R-HSA-432040 Reactome Name: Vasopressin regulates renal water homeostasis via Aquaporins See in Reactome R-HSA-5610783 R-HSA-5610783 Reactome Name: Degradation of GLI2 by the proteasome See in Reactome R-HSA-111931 R-HSA-111931 Reactome Name: PKA-mediated phosphorylation of CREB See in Reactome R-HSA-180024 R-HSA-180024 Reactome Name: DARPP-32 events See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-163615 R-HSA-163615 Reactome Name: PKA activation See in Reactome R-HSA-5610785 R-HSA-5610785 Reactome Name: GLI3 is processed to GLI3R by the proteasome See in Reactome R-HSA-164378 R-HSA-164378 Reactome Name: PKA activation in glucagon signalling See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9010642 R-HSA-9010642 Reactome Name: ROBO receptors bind AKAP5 See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9634600 R-HSA-9634600 Reactome Name: Regulation of glycolysis by fructose 2,6-bisphosphate metabolism See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-163560 R-HSA-163560 Reactome Name: Triglyceride catabolism See in Reactome R-HSA-5610780 R-HSA-5610780 Reactome Name: Degradation of GLI1 by the proteasome See in Reactome R-HSA-8963896 R-HSA-8963896 Reactome Name: HDL assembly See in Reactome R-HSA-392517 R-HSA-392517 Reactome Name: Rap1 signalling See in Reactome R-HSA-163358 R-HSA-163358 Reactome Name: PKA-mediated phosphorylation of key metabolic factors See in Reactome R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-8979227 R-HSA-8979227 Reactome Name: Triglyceride metabolism See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-445717 R-HSA-445717 Reactome Name: Aquaporin-mediated transport See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-8963898 R-HSA-8963898 Reactome Name: Plasma lipoprotein assembly See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-163359 R-HSA-163359 Reactome Name: Glucagon signaling in metabolic regulation See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Transport of small molecules Metabolism Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-111919 ( R-HSA-111931; R-HSA-442720 ) R-HSA-111919 Reaction Name: PKA phosphorylates CREB1 See in Reactome R-HSA-111924 ( R-HSA-111931; R-HSA-442720 ) R-HSA-111924 Reaction Name: PKA catalytic subunit translocates to the nucleus See in Reactome R-HSA-111925 ( R-HSA-111931; R-HSA-163615; R-HSA-164378; R-HSA-180024; R-HSA-432040; R-HSA-442720 ) R-HSA-111925 Reaction Name: cAMP induces dissociation of inactive PKA tetramers See in Reactome R-HSA-163416 ( R-HSA-163560 ) R-HSA-163416 Reaction Name: hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP See in Reactome R-HSA-163418 ( R-HSA-163560 ) R-HSA-163418 Reaction Name: perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP See in Reactome R-HSA-163672 ( R-HSA-163358 ) R-HSA-163672 Reaction Name: Phosphorylation of ChREBP at Thr(666) by PKA See in Reactome R-HSA-163676 ( R-HSA-163358 ) R-HSA-163676 Reaction Name: Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA See in Reactome R-HSA-163773 ( R-HSA-163358; R-HSA-9634600 ) R-HSA-163773 Reaction Name: Phosphorylation of PF2K-Pase by PKA catalytic subunit See in Reactome R-HSA-177275 ( R-HSA-180024 ) R-HSA-177275 Reaction Name: PKA phosphorylates DARPP-32 on Thr34 See in Reactome R-HSA-177284 ( R-HSA-180024 ) R-HSA-177284 Reaction Name: PKA phosphorylates PDE4B See in Reactome R-HSA-265682 ( R-HSA-422356 ) R-HSA-265682 Reaction Name: KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel See in Reactome R-HSA-381644 ( R-HSA-381676; R-HSA-422356 ) R-HSA-381644 Reaction Name: ER calcium channels open in response to activated PKA See in Reactome R-HSA-381707 ( R-HSA-381676; R-HSA-422356 ) R-HSA-381707 Reaction Name: PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP See in Reactome R-HSA-381713 ( R-HSA-381676; R-HSA-422356 ) R-HSA-381713 Reaction Name: Potassium voltage-gated channels close in reponse to PKA See in Reactome R-HSA-432232 ( R-HSA-432040 ) R-HSA-432232 Reaction Name: Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) See in Reactome R-HSA-5218854 ( R-HSA-4420097 ) R-HSA-5218854 Reaction Name: p-Y420-FYN is phosphorylated on S21 See in Reactome R-HSA-5610717 ( R-HSA-5610783; R-HSA-5610787 ) R-HSA-5610717 Reaction Name: PKA phosphorylates GLI2 See in Reactome R-HSA-5610720 ( R-HSA-5610785; R-HSA-5610787 ) R-HSA-5610720 Reaction Name: PKA phosphorylates GLI3 See in Reactome R-HSA-5610741 ( R-HSA-5610780; R-HSA-5610787 ) R-HSA-5610741 Reaction Name: PKA phosphorylates GLI1 See in Reactome R-HSA-5610749 ( R-HSA-5610787 ) R-HSA-5610749 Reaction Name: cAMP dissociates PKA, promoting GLI processing See in Reactome R-HSA-5624473 ( R-HSA-5621575 ) R-HSA-5624473 Reaction Name: Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit See in Reactome R-HSA-5682101 ( R-HSA-8963896 ) R-HSA-5682101 Reaction Name: PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer See in Reactome R-HSA-5687088 ( R-HSA-5687128 ) R-HSA-5687088 Reaction Name: PKA phosphorylates MAPKAPK5 See in Reactome R-HSA-8854908 ( R-HSA-8853659 ) R-HSA-8854908 Reaction Name: PKA phosphorylates RET:GDNF:GFRA dimer See in Reactome R-HSA-8951727 ( R-HSA-111931; R-HSA-163615; R-HSA-180024; R-HSA-432040; R-HSA-442720 ) R-HSA-8951727 Reaction Name: cAMP binds PKA tetramer See in Reactome R-HSA-9010641 ( R-HSA-9010642 ) R-HSA-9010641 Reaction Name: AKAP5 recruits PKA to ROBO2 See in Reactome R-HSA-913996 ( R-HSA-392517 ) R-HSA-913996 Reaction Name: PKA/PKG phosphorylate Rap1GAP2 See in Reactome R-HSA-992708 ( R-HSA-983231 ) R-HSA-992708 Reaction Name: Dual-specific AKAPs bind type I and II PKA regulatory subunits See in Reactome
MONDO:0030924	PSMB10	P40306	3.4.25.1	R-HSA-8951664 R-HSA-8951664 Reactome Name: Neddylation See in Reactome R-HSA-4608870 R-HSA-4608870 Reactome Name: Asymmetric localization of PCP proteins See in Reactome R-HSA-2467813 R-HSA-2467813 Reactome Name: Separation of Sister Chromatids See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-8852276 R-HSA-8852276 Reactome Name: The role of GTSE1 in G2/M progression after G2 checkpoint See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-174184 R-HSA-174184 Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A See in Reactome R-HSA-69017 R-HSA-69017 Reactome Name: CDK-mediated phosphorylation and removal of Cdc6 See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-187577 R-HSA-187577 Reactome Name: SCF(Skp2)-mediated degradation of p27/p21 See in Reactome R-HSA-1236978 R-HSA-1236978 Reactome Name: Cross-presentation of soluble exogenous antigens (endosomes) See in Reactome R-HSA-5610780 R-HSA-5610780 Reactome Name: Degradation of GLI1 by the proteasome See in Reactome R-HSA-5610785 R-HSA-5610785 Reactome Name: GLI3 is processed to GLI3R by the proteasome See in Reactome R-HSA-8854050 R-HSA-8854050 Reactome Name: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis See in Reactome R-HSA-69601 R-HSA-69601 Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A See in Reactome R-HSA-1236974 R-HSA-1236974 Reactome Name: ER-Phagosome pathway See in Reactome R-HSA-5610783 R-HSA-5610783 Reactome Name: Degradation of GLI2 by the proteasome See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-5668541 R-HSA-5668541 Reactome Name: TNFR2 non-canonical NF-kB pathway See in Reactome R-HSA-1169091 R-HSA-1169091 Reactome Name: Activation of NF-kappaB in B cells See in Reactome R-HSA-4641258 R-HSA-4641258 Reactome Name: Degradation of DVL See in Reactome R-HSA-9010553 R-HSA-9010553 Reactome Name: Regulation of expression of SLITs and ROBOs See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-450408 R-HSA-450408 Reactome Name: AUF1 (hnRNP D0) binds and destabilizes mRNA See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-5676590 R-HSA-5676590 Reactome Name: NIK-->noncanonical NF-kB signaling See in Reactome R-HSA-1234176 R-HSA-1234176 Reactome Name: Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha See in Reactome R-HSA-211733 R-HSA-211733 Reactome Name: Regulation of activated PAK-2p34 by proteasome mediated degradation See in Reactome R-HSA-4641257 R-HSA-4641257 Reactome Name: Degradation of AXIN See in Reactome R-HSA-5607761 R-HSA-5607761 Reactome Name: Dectin-1 mediated noncanonical NF-kB signaling See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-8939236 R-HSA-8939236 Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs See in Reactome R-HSA-174178 R-HSA-174178 Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 See in Reactome R-HSA-8939902 R-HSA-8939902 Reactome Name: Regulation of RUNX2 expression and activity See in Reactome R-HSA-349425 R-HSA-349425 Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1 See in Reactome R-HSA-68949 R-HSA-68949 Reactome Name: Orc1 removal from chromatin See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-174154 R-HSA-174154 Reactome Name: APC/C:Cdc20 mediated degradation of Securin See in Reactome R-HSA-195253 R-HSA-195253 Reactome Name: Degradation of beta-catenin by the destruction complex See in Reactome R-HSA-174084 R-HSA-174084 Reactome Name: Autodegradation of Cdh1 by Cdh1:APC/C See in Reactome R-HSA-174113 R-HSA-174113 Reactome Name: SCF-beta-TrCP mediated degradation of Emi1 See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-350562 R-HSA-350562 Reactome Name: Regulation of ornithine decarboxylase (ODC) See in Reactome R-HSA-5632684 R-HSA-5632684 Reactome Name: Hedgehog 'on' state See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-75815 R-HSA-75815 Reactome Name: Ubiquitin-dependent degradation of Cyclin D See in Reactome R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-2871837 R-HSA-2871837 Reactome Name: FCERI mediated NF-kB activation See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-174143 R-HSA-174143 Reactome Name: APC/C-mediated degradation of cell cycle proteins See in Reactome R-HSA-69052 R-HSA-69052 Reactome Name: Switching of origins to a post-replicative state See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-69541 R-HSA-69541 Reactome Name: Stabilization of p53 See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-179419 R-HSA-179419 Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint See in Reactome R-HSA-69580 R-HSA-69580 Reactome Name: p53-Dependent G1/S DNA damage checkpoint See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-176408 R-HSA-176408 Reactome Name: Regulation of APC/C activators between G1/S and early anaphase See in Reactome R-HSA-176409 R-HSA-176409 Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins See in Reactome R-HSA-169911 R-HSA-169911 Reactome Name: Regulation of Apoptosis See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-453276 R-HSA-453276 Reactome Name: Regulation of mitotic cell cycle See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-69563 R-HSA-69563 Reactome Name: p53-Dependent G1 DNA Damage Response See in Reactome R-HSA-176814 R-HSA-176814 Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-351202 R-HSA-351202 Reactome Name: Metabolism of polyamines See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-69615 R-HSA-69615 Reactome Name: G1/S DNA Damage Checkpoints See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69610 R-HSA-69610 Reactome Name: p53-Independent DNA Damage Response See in Reactome R-HSA-69613 R-HSA-69613 Reactome Name: p53-Independent G1/S DNA damage checkpoint See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome	Cellular responses to stimuli Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Transport of small molecules Metabolism of RNA Metabolism of proteins DNA Replication Signal Transduction	R-HSA-1168640 ( R-HSA-1169091 ) R-HSA-1168640 Reaction Name: Ubiquitinated IkB is degraded See in Reactome R-HSA-1234159 ( R-HSA-1234176 ) R-HSA-1234159 Reaction Name: Proteasome proteolyzes ub-HIF-alpha See in Reactome R-HSA-1236935 ( R-HSA-1236974 ) R-HSA-1236935 Reaction Name: Proteasomal cleavage of substrate See in Reactome R-HSA-1236970 ( R-HSA-1236978 ) R-HSA-1236970 Reaction Name: Proteasomal clevage of exogenous antigen See in Reactome R-HSA-1504193 ( R-HSA-4641258 ) R-HSA-1504193 Reaction Name: Ubiquitinated DVL is degraded by the proteasome See in Reactome R-HSA-174058 ( R-HSA-174084 ) R-HSA-174058 Reaction Name: Degradation of multiubiquitinated Cdh1 See in Reactome R-HSA-174105 ( R-HSA-174178 ) R-HSA-174105 Reaction Name: Degradation of multiubiquitinated cell cycle proteins See in Reactome R-HSA-174202 ( R-HSA-174154; R-HSA-2467813 ) R-HSA-174202 Reaction Name: Degradation of multiubiquitinated Securin See in Reactome R-HSA-174203 ( R-HSA-174113 ) R-HSA-174203 Reaction Name: SCF-mediated degradation of Emi1 See in Reactome R-HSA-174255 ( R-HSA-174184 ) R-HSA-174255 Reaction Name: Degradation multiubiquitinated Cyclin A See in Reactome R-HSA-187574 ( R-HSA-187577 ) R-HSA-187574 Reaction Name: Degradation of ubiquitinated p27/p21 by the 26S proteasome See in Reactome R-HSA-188191 ( R-HSA-174178 ) R-HSA-188191 Reaction Name: APC/C:Cdh1-mediated degradation of Skp2 See in Reactome R-HSA-209061 ( R-HSA-9020702 ) R-HSA-209061 Reaction Name: Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex See in Reactome R-HSA-211715 ( R-HSA-211733 ) R-HSA-211715 Reaction Name: Proteasome mediated degradation of PAK-2p34 See in Reactome R-HSA-2130282 ( R-HSA-195253 ) R-HSA-2130282 Reaction Name: Degradation of ubiquitinated beta catenin by the proteasome See in Reactome R-HSA-264458 ( R-HSA-349425 ) R-HSA-264458 Reaction Name: Proteasome mediated degradation of COP1 See in Reactome R-HSA-353125 ( R-HSA-350562 ) R-HSA-353125 Reaction Name: 26S proteosome degrades ODC holoenzyme complex See in Reactome R-HSA-3640874 ( R-HSA-4641257 ) R-HSA-3640874 Reaction Name: Ub-RibC-AXIN is degraded by the proteasome See in Reactome R-HSA-450466 ( R-HSA-450408 ) R-HSA-450466 Reaction Name: AUF1:mRNA complex is destroyed See in Reactome R-HSA-4608855 ( R-HSA-4608870 ) R-HSA-4608855 Reaction Name: PRICKLE1 is degraded by the proteasome See in Reactome R-HSA-4641256 ( R-HSA-4641257 ) R-HSA-4641256 Reaction Name: Ubiquitinated AXIN is degraded by the proteasome See in Reactome R-HSA-4641260 ( R-HSA-4641258 ) R-HSA-4641260 Reaction Name: Ubiquitinated DVL1 is degraded by the proteasome See in Reactome R-HSA-5362448 ( R-HSA-5358346 ) R-HSA-5362448 Reaction Name: Hh C-terminal fragments are degraded by the proteasome See in Reactome R-HSA-5607724 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-5607724 Reaction Name: 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex See in Reactome R-HSA-5607731 ( R-HSA-5607761; R-HSA-5607764; R-HSA-5668541; R-HSA-5676590 ) R-HSA-5607731 Reaction Name: 26S proteasome processes p-7S-p100:RELB to form p52:RELB See in Reactome R-HSA-5610754 ( R-HSA-5610785 ) R-HSA-5610754 Reaction Name: GLI3 is partially degraded by the proteasome to yield the GLI3 repressor See in Reactome R-HSA-5610757 ( R-HSA-5610783 ) R-HSA-5610757 Reaction Name: GLI2 is degraded by the proteasome See in Reactome R-HSA-5610758 ( R-HSA-5610780 ) R-HSA-5610758 Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP See in Reactome R-HSA-5610760 ( R-HSA-5610780 ) R-HSA-5610760 Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by ITCH See in Reactome R-HSA-5635854 ( R-HSA-5632684 ) R-HSA-5635854 Reaction Name: GLI2,3 are degraded by the proteasome See in Reactome R-HSA-5635868 ( R-HSA-5632684 ) R-HSA-5635868 Reaction Name: ub-GLI is degraded by the proteasome See in Reactome R-HSA-5658430 ( R-HSA-5658442 ) R-HSA-5658430 Reaction Name: NF1 is degraded by the proteasome See in Reactome R-HSA-5665854 ( R-HSA-5689603 ) R-HSA-5665854 Reaction Name: ADRM1:26S proteaseome binds UCHL5 See in Reactome R-HSA-5665871 ( R-HSA-5689603 ) R-HSA-5665871 Reaction Name: ADRM1 binds 26S proteasome See in Reactome R-HSA-5668481 ( R-HSA-5668541 ) R-HSA-5668481 Reaction Name: Protesomal degradation of K48polyUb-TRAF3 See in Reactome R-HSA-5668520 ( R-HSA-5668541 ) R-HSA-5668520 Reaction Name: 26Sproteasome degrades K48polyUb-NIK See in Reactome R-HSA-5687112 ( R-HSA-5687128 ) R-HSA-5687112 Reaction Name: MAPK6 is degraded by the 26S proteasome See in Reactome R-HSA-5689539 ( R-HSA-5689880 ) R-HSA-5689539 Reaction Name: ADRM1:26S proteaseome binds USP14 See in Reactome R-HSA-68825 () R-HSA-68825 Reaction Name: Ubiquitinated geminin is degraded by the proteasome See in Reactome R-HSA-68948 ( R-HSA-68949 ) R-HSA-68948 Reaction Name: Ubiquitinated Orc1 is degraded by the proteasome See in Reactome R-HSA-69016 ( R-HSA-69017 ) R-HSA-69016 Reaction Name: Ubiquitinated Cdc6 is degraded by the proteasome See in Reactome R-HSA-69600 ( R-HSA-69601 ) R-HSA-69600 Reaction Name: Proteolytic degradation of ubiquitinated-Cdc25A See in Reactome R-HSA-75825 ( R-HSA-75815 ) R-HSA-75825 Reaction Name: Proteasome mediated degradation of Cyclin D1 See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8852354 ( R-HSA-69481; R-HSA-8852276 ) R-HSA-8852354 Reaction Name: GTSE1 facilitates proteasome-mediated degradation of TP53 See in Reactome R-HSA-8854044 ( R-HSA-8854050 ) R-HSA-8854044 Reaction Name: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 See in Reactome R-HSA-8854071 ( R-HSA-8854050 ) R-HSA-8854071 Reaction Name: Proteasome-mediated degradation of PolyUb-FBXL7 See in Reactome R-HSA-8866553 ( R-HSA-382556 ) R-HSA-8866553 Reaction Name: misfolded CFTR is degraded by the 26S proteasome See in Reactome R-HSA-8932355 ( R-HSA-8951664 ) R-HSA-8932355 Reaction Name: 26S proteasome degrades Ub-NFE2L2 See in Reactome R-HSA-8939801 ( R-HSA-8939902 ) R-HSA-8939801 Reaction Name: 26S proteasome degrades PolyUb-RUNX2 See in Reactome R-HSA-8952408 ( R-HSA-8941858 ) R-HSA-8952408 Reaction Name: Polyubiquitinated RUNX3 is degraded by the proteasome See in Reactome R-HSA-8956140 ( R-HSA-8951664 ) R-HSA-8956140 Reaction Name: NEDD8 and UBD bind NUB1 and the 26S proteasome See in Reactome R-HSA-8956184 ( R-HSA-8951664 ) R-HSA-8956184 Reaction Name: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates See in Reactome R-HSA-8957265 ( R-HSA-8939236 ) R-HSA-8957265 Reaction Name: 26S proteasome degrades TP73 polyubiquitinated by ITCH See in Reactome R-HSA-9008110 ( R-HSA-8939902 ) R-HSA-9008110 Reaction Name: Proteasome degrades polyubiquitinated RUNX2 See in Reactome R-HSA-9008475 ( R-HSA-8939902 ) R-HSA-9008475 Reaction Name: Proteasome degrades polyubiquitinated RUNX2 See in Reactome R-HSA-9009362 ( R-HSA-8939902 ) R-HSA-9009362 Reaction Name: Proteasome degrades PolyUb-RUNX2 See in Reactome R-HSA-9011313 ( R-HSA-9010553 ) R-HSA-9011313 Reaction Name: Proteasome degrades ubiquitinated ROBO3.1 See in Reactome R-HSA-9604642 ( R-HSA-9604323 ) R-HSA-9604642 Reaction Name: Proteasome degrades ubiquitinated NICD4 See in Reactome R-HSA-9755303 ( R-HSA-8951664 ) R-HSA-9755303 Reaction Name: 26S proteasome degrades HIFalpha See in Reactome R-HSA-9755306 ( R-HSA-8951664 ) R-HSA-9755306 Reaction Name: ub UBXN7 is degraded by the 26S proteasome See in Reactome R-HSA-9762096 () R-HSA-9762096 Reaction Name: Ub,pS335,S338,T NFE2L2 is degraded See in Reactome R-HSA-983150 ( R-HSA-983168 ) R-HSA-983150 Reaction Name: Proteasomal cleavage of substrate See in Reactome
MONDO:0054698	PSMB8	P28062	3.4.25.1	R-HSA-8951664 R-HSA-8951664 Reactome Name: Neddylation See in Reactome R-HSA-4608870 R-HSA-4608870 Reactome Name: Asymmetric localization of PCP proteins See in Reactome R-HSA-2467813 R-HSA-2467813 Reactome Name: Separation of Sister Chromatids See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-8852276 R-HSA-8852276 Reactome Name: The role of GTSE1 in G2/M progression after G2 checkpoint See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-174184 R-HSA-174184 Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A See in Reactome R-HSA-69017 R-HSA-69017 Reactome Name: CDK-mediated phosphorylation and removal of Cdc6 See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-187577 R-HSA-187577 Reactome Name: SCF(Skp2)-mediated degradation of p27/p21 See in Reactome R-HSA-1236978 R-HSA-1236978 Reactome Name: Cross-presentation of soluble exogenous antigens (endosomes) See in Reactome R-HSA-5610780 R-HSA-5610780 Reactome Name: Degradation of GLI1 by the proteasome See in Reactome R-HSA-5610785 R-HSA-5610785 Reactome Name: GLI3 is processed to GLI3R by the proteasome See in Reactome R-HSA-8854050 R-HSA-8854050 Reactome Name: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis See in Reactome R-HSA-69601 R-HSA-69601 Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A See in Reactome R-HSA-1236974 R-HSA-1236974 Reactome Name: ER-Phagosome pathway See in Reactome R-HSA-5610783 R-HSA-5610783 Reactome Name: Degradation of GLI2 by the proteasome See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-5668541 R-HSA-5668541 Reactome Name: TNFR2 non-canonical NF-kB pathway See in Reactome R-HSA-1169091 R-HSA-1169091 Reactome Name: Activation of NF-kappaB in B cells See in Reactome R-HSA-4641258 R-HSA-4641258 Reactome Name: Degradation of DVL See in Reactome R-HSA-9010553 R-HSA-9010553 Reactome Name: Regulation of expression of SLITs and ROBOs See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-450408 R-HSA-450408 Reactome Name: AUF1 (hnRNP D0) binds and destabilizes mRNA See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-5676590 R-HSA-5676590 Reactome Name: NIK-->noncanonical NF-kB signaling See in Reactome R-HSA-1234176 R-HSA-1234176 Reactome Name: Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha See in Reactome R-HSA-211733 R-HSA-211733 Reactome Name: Regulation of activated PAK-2p34 by proteasome mediated degradation See in Reactome R-HSA-4641257 R-HSA-4641257 Reactome Name: Degradation of AXIN See in Reactome R-HSA-5607761 R-HSA-5607761 Reactome Name: Dectin-1 mediated noncanonical NF-kB signaling See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-8939236 R-HSA-8939236 Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs See in Reactome R-HSA-174178 R-HSA-174178 Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 See in Reactome R-HSA-8939902 R-HSA-8939902 Reactome Name: Regulation of RUNX2 expression and activity See in Reactome R-HSA-349425 R-HSA-349425 Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1 See in Reactome R-HSA-68949 R-HSA-68949 Reactome Name: Orc1 removal from chromatin See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-174154 R-HSA-174154 Reactome Name: APC/C:Cdc20 mediated degradation of Securin See in Reactome R-HSA-195253 R-HSA-195253 Reactome Name: Degradation of beta-catenin by the destruction complex See in Reactome R-HSA-174084 R-HSA-174084 Reactome Name: Autodegradation of Cdh1 by Cdh1:APC/C See in Reactome R-HSA-174113 R-HSA-174113 Reactome Name: SCF-beta-TrCP mediated degradation of Emi1 See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-350562 R-HSA-350562 Reactome Name: Regulation of ornithine decarboxylase (ODC) See in Reactome R-HSA-5632684 R-HSA-5632684 Reactome Name: Hedgehog 'on' state See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-75815 R-HSA-75815 Reactome Name: Ubiquitin-dependent degradation of Cyclin D See in Reactome R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-2871837 R-HSA-2871837 Reactome Name: FCERI mediated NF-kB activation See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-174143 R-HSA-174143 Reactome Name: APC/C-mediated degradation of cell cycle proteins See in Reactome R-HSA-69052 R-HSA-69052 Reactome Name: Switching of origins to a post-replicative state See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-69541 R-HSA-69541 Reactome Name: Stabilization of p53 See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-179419 R-HSA-179419 Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-69580 R-HSA-69580 Reactome Name: p53-Dependent G1/S DNA damage checkpoint See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-176408 R-HSA-176408 Reactome Name: Regulation of APC/C activators between G1/S and early anaphase See in Reactome R-HSA-176409 R-HSA-176409 Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins See in Reactome R-HSA-169911 R-HSA-169911 Reactome Name: Regulation of Apoptosis See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-453276 R-HSA-453276 Reactome Name: Regulation of mitotic cell cycle See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-69563 R-HSA-69563 Reactome Name: p53-Dependent G1 DNA Damage Response See in Reactome R-HSA-176814 R-HSA-176814 Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-351202 R-HSA-351202 Reactome Name: Metabolism of polyamines See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-69615 R-HSA-69615 Reactome Name: G1/S DNA Damage Checkpoints See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69610 R-HSA-69610 Reactome Name: p53-Independent DNA Damage Response See in Reactome R-HSA-69613 R-HSA-69613 Reactome Name: p53-Independent G1/S DNA damage checkpoint See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome	Cellular responses to stimuli Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Transport of small molecules Metabolism of RNA Metabolism of proteins DNA Replication Signal Transduction	R-HSA-1015702 ( R-HSA-909733 ) R-HSA-1015702 Reaction Name: Expression of IFN-induced genes See in Reactome R-HSA-1168640 ( R-HSA-1169091 ) R-HSA-1168640 Reaction Name: Ubiquitinated IkB is degraded See in Reactome R-HSA-1234159 ( R-HSA-1234176 ) R-HSA-1234159 Reaction Name: Proteasome proteolyzes ub-HIF-alpha See in Reactome R-HSA-1236935 ( R-HSA-1236974 ) R-HSA-1236935 Reaction Name: Proteasomal cleavage of substrate See in Reactome R-HSA-1236970 ( R-HSA-1236978 ) R-HSA-1236970 Reaction Name: Proteasomal clevage of exogenous antigen See in Reactome R-HSA-1504193 ( R-HSA-4641258 ) R-HSA-1504193 Reaction Name: Ubiquitinated DVL is degraded by the proteasome See in Reactome R-HSA-174058 ( R-HSA-174084 ) R-HSA-174058 Reaction Name: Degradation of multiubiquitinated Cdh1 See in Reactome R-HSA-174105 ( R-HSA-174178 ) R-HSA-174105 Reaction Name: Degradation of multiubiquitinated cell cycle proteins See in Reactome R-HSA-174202 ( R-HSA-174154; R-HSA-2467813 ) R-HSA-174202 Reaction Name: Degradation of multiubiquitinated Securin See in Reactome R-HSA-174203 ( R-HSA-174113 ) R-HSA-174203 Reaction Name: SCF-mediated degradation of Emi1 See in Reactome R-HSA-174255 ( R-HSA-174184 ) R-HSA-174255 Reaction Name: Degradation multiubiquitinated Cyclin A See in Reactome R-HSA-187574 ( R-HSA-187577 ) R-HSA-187574 Reaction Name: Degradation of ubiquitinated p27/p21 by the 26S proteasome See in Reactome R-HSA-188191 ( R-HSA-174178 ) R-HSA-188191 Reaction Name: APC/C:Cdh1-mediated degradation of Skp2 See in Reactome R-HSA-209061 ( R-HSA-9020702 ) R-HSA-209061 Reaction Name: Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex See in Reactome R-HSA-211715 ( R-HSA-211733 ) R-HSA-211715 Reaction Name: Proteasome mediated degradation of PAK-2p34 See in Reactome R-HSA-2130282 ( R-HSA-195253 ) R-HSA-2130282 Reaction Name: Degradation of ubiquitinated beta catenin by the proteasome See in Reactome R-HSA-264458 ( R-HSA-349425 ) R-HSA-264458 Reaction Name: Proteasome mediated degradation of COP1 See in Reactome R-HSA-353125 ( R-HSA-350562 ) R-HSA-353125 Reaction Name: 26S proteosome degrades ODC holoenzyme complex See in Reactome R-HSA-3640874 ( R-HSA-4641257 ) R-HSA-3640874 Reaction Name: Ub-RibC-AXIN is degraded by the proteasome See in Reactome R-HSA-450466 ( R-HSA-450408 ) R-HSA-450466 Reaction Name: AUF1:mRNA complex is destroyed See in Reactome R-HSA-4608855 ( R-HSA-4608870 ) R-HSA-4608855 Reaction Name: PRICKLE1 is degraded by the proteasome See in Reactome R-HSA-4641256 ( R-HSA-4641257 ) R-HSA-4641256 Reaction Name: Ubiquitinated AXIN is degraded by the proteasome See in Reactome R-HSA-4641260 ( R-HSA-4641258 ) R-HSA-4641260 Reaction Name: Ubiquitinated DVL1 is degraded by the proteasome See in Reactome R-HSA-5362448 ( R-HSA-5358346 ) R-HSA-5362448 Reaction Name: Hh C-terminal fragments are degraded by the proteasome See in Reactome R-HSA-5607724 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-5607724 Reaction Name: 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex See in Reactome R-HSA-5607731 ( R-HSA-5607761; R-HSA-5607764; R-HSA-5668541; R-HSA-5676590 ) R-HSA-5607731 Reaction Name: 26S proteasome processes p-7S-p100:RELB to form p52:RELB See in Reactome R-HSA-5610754 ( R-HSA-5610785; R-HSA-5610787 ) R-HSA-5610754 Reaction Name: GLI3 is partially degraded by the proteasome to yield the GLI3 repressor See in Reactome R-HSA-5610757 ( R-HSA-5610783; R-HSA-5610787 ) R-HSA-5610757 Reaction Name: GLI2 is degraded by the proteasome See in Reactome R-HSA-5610758 ( R-HSA-5610780; R-HSA-5610787 ) R-HSA-5610758 Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP See in Reactome R-HSA-5610760 ( R-HSA-5610780; R-HSA-5610787 ) R-HSA-5610760 Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by ITCH See in Reactome R-HSA-5635854 ( R-HSA-5632684 ) R-HSA-5635854 Reaction Name: GLI2,3 are degraded by the proteasome See in Reactome R-HSA-5635868 ( R-HSA-5632684 ) R-HSA-5635868 Reaction Name: ub-GLI is degraded by the proteasome See in Reactome R-HSA-5658430 ( R-HSA-5658442 ) R-HSA-5658430 Reaction Name: NF1 is degraded by the proteasome See in Reactome R-HSA-5665854 ( R-HSA-5689603 ) R-HSA-5665854 Reaction Name: ADRM1:26S proteaseome binds UCHL5 See in Reactome R-HSA-5665871 ( R-HSA-5689603 ) R-HSA-5665871 Reaction Name: ADRM1 binds 26S proteasome See in Reactome R-HSA-5668481 ( R-HSA-5668541 ) R-HSA-5668481 Reaction Name: Protesomal degradation of K48polyUb-TRAF3 See in Reactome R-HSA-5668520 ( R-HSA-5668541 ) R-HSA-5668520 Reaction Name: 26Sproteasome degrades K48polyUb-NIK See in Reactome R-HSA-5687112 ( R-HSA-5687128 ) R-HSA-5687112 Reaction Name: MAPK6 is degraded by the 26S proteasome See in Reactome R-HSA-5689539 ( R-HSA-5689880 ) R-HSA-5689539 Reaction Name: ADRM1:26S proteaseome binds USP14 See in Reactome R-HSA-68825 () R-HSA-68825 Reaction Name: Ubiquitinated geminin is degraded by the proteasome See in Reactome R-HSA-68948 ( R-HSA-68949 ) R-HSA-68948 Reaction Name: Ubiquitinated Orc1 is degraded by the proteasome See in Reactome R-HSA-69016 ( R-HSA-69017 ) R-HSA-69016 Reaction Name: Ubiquitinated Cdc6 is degraded by the proteasome See in Reactome R-HSA-69600 ( R-HSA-69601 ) R-HSA-69600 Reaction Name: Proteolytic degradation of ubiquitinated-Cdc25A See in Reactome R-HSA-75825 ( R-HSA-75815 ) R-HSA-75825 Reaction Name: Proteasome mediated degradation of Cyclin D1 See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8852354 ( R-HSA-69481; R-HSA-8852276 ) R-HSA-8852354 Reaction Name: GTSE1 facilitates proteasome-mediated degradation of TP53 See in Reactome R-HSA-8854044 ( R-HSA-8854050 ) R-HSA-8854044 Reaction Name: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 See in Reactome R-HSA-8854071 ( R-HSA-8854050 ) R-HSA-8854071 Reaction Name: Proteasome-mediated degradation of PolyUb-FBXL7 See in Reactome R-HSA-8866553 ( R-HSA-382556 ) R-HSA-8866553 Reaction Name: misfolded CFTR is degraded by the 26S proteasome See in Reactome R-HSA-8932355 ( R-HSA-8951664 ) R-HSA-8932355 Reaction Name: 26S proteasome degrades Ub-NFE2L2 See in Reactome R-HSA-8939801 ( R-HSA-8939902 ) R-HSA-8939801 Reaction Name: 26S proteasome degrades PolyUb-RUNX2 See in Reactome R-HSA-8952408 ( R-HSA-8941858 ) R-HSA-8952408 Reaction Name: Polyubiquitinated RUNX3 is degraded by the proteasome See in Reactome R-HSA-8956140 ( R-HSA-8951664 ) R-HSA-8956140 Reaction Name: NEDD8 and UBD bind NUB1 and the 26S proteasome See in Reactome R-HSA-8956184 ( R-HSA-8951664 ) R-HSA-8956184 Reaction Name: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates See in Reactome R-HSA-8957265 ( R-HSA-8939236 ) R-HSA-8957265 Reaction Name: 26S proteasome degrades TP73 polyubiquitinated by ITCH See in Reactome R-HSA-9008110 ( R-HSA-8939902 ) R-HSA-9008110 Reaction Name: Proteasome degrades polyubiquitinated RUNX2 See in Reactome R-HSA-9008475 ( R-HSA-8939902 ) R-HSA-9008475 Reaction Name: Proteasome degrades polyubiquitinated RUNX2 See in Reactome R-HSA-9009362 ( R-HSA-8939902 ) R-HSA-9009362 Reaction Name: Proteasome degrades PolyUb-RUNX2 See in Reactome R-HSA-9011313 ( R-HSA-9010553 ) R-HSA-9011313 Reaction Name: Proteasome degrades ubiquitinated ROBO3.1 See in Reactome R-HSA-9604642 ( R-HSA-9604323 ) R-HSA-9604642 Reaction Name: Proteasome degrades ubiquitinated NICD4 See in Reactome R-HSA-9755303 ( R-HSA-8951664 ) R-HSA-9755303 Reaction Name: 26S proteasome degrades HIFalpha See in Reactome R-HSA-9755306 ( R-HSA-8951664 ) R-HSA-9755306 Reaction Name: ub UBXN7 is degraded by the 26S proteasome See in Reactome R-HSA-9762096 () R-HSA-9762096 Reaction Name: Ub,pS335,S338,T NFE2L2 is degraded See in Reactome R-HSA-983150 ( R-HSA-983168 ) R-HSA-983150 Reaction Name: Proteasomal cleavage of substrate See in Reactome
MONDO:0054699	PSMB9	P28065	3.4.25.1	R-HSA-8951664 R-HSA-8951664 Reactome Name: Neddylation See in Reactome R-HSA-4608870 R-HSA-4608870 Reactome Name: Asymmetric localization of PCP proteins See in Reactome R-HSA-2467813 R-HSA-2467813 Reactome Name: Separation of Sister Chromatids See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-8852276 R-HSA-8852276 Reactome Name: The role of GTSE1 in G2/M progression after G2 checkpoint See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-174184 R-HSA-174184 Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A See in Reactome R-HSA-69017 R-HSA-69017 Reactome Name: CDK-mediated phosphorylation and removal of Cdc6 See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-187577 R-HSA-187577 Reactome Name: SCF(Skp2)-mediated degradation of p27/p21 See in Reactome R-HSA-1236978 R-HSA-1236978 Reactome Name: Cross-presentation of soluble exogenous antigens (endosomes) See in Reactome R-HSA-5610780 R-HSA-5610780 Reactome Name: Degradation of GLI1 by the proteasome See in Reactome R-HSA-5610785 R-HSA-5610785 Reactome Name: GLI3 is processed to GLI3R by the proteasome See in Reactome R-HSA-8854050 R-HSA-8854050 Reactome Name: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis See in Reactome R-HSA-69601 R-HSA-69601 Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A See in Reactome R-HSA-1236974 R-HSA-1236974 Reactome Name: ER-Phagosome pathway See in Reactome R-HSA-5610783 R-HSA-5610783 Reactome Name: Degradation of GLI2 by the proteasome See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-5668541 R-HSA-5668541 Reactome Name: TNFR2 non-canonical NF-kB pathway See in Reactome R-HSA-1169091 R-HSA-1169091 Reactome Name: Activation of NF-kappaB in B cells See in Reactome R-HSA-4641258 R-HSA-4641258 Reactome Name: Degradation of DVL See in Reactome R-HSA-9010553 R-HSA-9010553 Reactome Name: Regulation of expression of SLITs and ROBOs See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-450408 R-HSA-450408 Reactome Name: AUF1 (hnRNP D0) binds and destabilizes mRNA See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-5676590 R-HSA-5676590 Reactome Name: NIK-->noncanonical NF-kB signaling See in Reactome R-HSA-1234176 R-HSA-1234176 Reactome Name: Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha See in Reactome R-HSA-211733 R-HSA-211733 Reactome Name: Regulation of activated PAK-2p34 by proteasome mediated degradation See in Reactome R-HSA-4641257 R-HSA-4641257 Reactome Name: Degradation of AXIN See in Reactome R-HSA-5607761 R-HSA-5607761 Reactome Name: Dectin-1 mediated noncanonical NF-kB signaling See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-8939236 R-HSA-8939236 Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs See in Reactome R-HSA-174178 R-HSA-174178 Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 See in Reactome R-HSA-8939902 R-HSA-8939902 Reactome Name: Regulation of RUNX2 expression and activity See in Reactome R-HSA-349425 R-HSA-349425 Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1 See in Reactome R-HSA-68949 R-HSA-68949 Reactome Name: Orc1 removal from chromatin See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-174154 R-HSA-174154 Reactome Name: APC/C:Cdc20 mediated degradation of Securin See in Reactome R-HSA-195253 R-HSA-195253 Reactome Name: Degradation of beta-catenin by the destruction complex See in Reactome R-HSA-174084 R-HSA-174084 Reactome Name: Autodegradation of Cdh1 by Cdh1:APC/C See in Reactome R-HSA-174113 R-HSA-174113 Reactome Name: SCF-beta-TrCP mediated degradation of Emi1 See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-350562 R-HSA-350562 Reactome Name: Regulation of ornithine decarboxylase (ODC) See in Reactome R-HSA-5632684 R-HSA-5632684 Reactome Name: Hedgehog 'on' state See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-75815 R-HSA-75815 Reactome Name: Ubiquitin-dependent degradation of Cyclin D See in Reactome R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-2871837 R-HSA-2871837 Reactome Name: FCERI mediated NF-kB activation See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-174143 R-HSA-174143 Reactome Name: APC/C-mediated degradation of cell cycle proteins See in Reactome R-HSA-69052 R-HSA-69052 Reactome Name: Switching of origins to a post-replicative state See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-69541 R-HSA-69541 Reactome Name: Stabilization of p53 See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-179419 R-HSA-179419 Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint See in Reactome R-HSA-69580 R-HSA-69580 Reactome Name: p53-Dependent G1/S DNA damage checkpoint See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-176408 R-HSA-176408 Reactome Name: Regulation of APC/C activators between G1/S and early anaphase See in Reactome R-HSA-176409 R-HSA-176409 Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins See in Reactome R-HSA-169911 R-HSA-169911 Reactome Name: Regulation of Apoptosis See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-453276 R-HSA-453276 Reactome Name: Regulation of mitotic cell cycle See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-69563 R-HSA-69563 Reactome Name: p53-Dependent G1 DNA Damage Response See in Reactome R-HSA-176814 R-HSA-176814 Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-351202 R-HSA-351202 Reactome Name: Metabolism of polyamines See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-69615 R-HSA-69615 Reactome Name: G1/S DNA Damage Checkpoints See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69610 R-HSA-69610 Reactome Name: p53-Independent DNA Damage Response See in Reactome R-HSA-69613 R-HSA-69613 Reactome Name: p53-Independent G1/S DNA damage checkpoint See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome	Cellular responses to stimuli Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Transport of small molecules Metabolism of RNA Metabolism of proteins DNA Replication Signal Transduction	R-HSA-1168640 ( R-HSA-1169091 ) R-HSA-1168640 Reaction Name: Ubiquitinated IkB is degraded See in Reactome R-HSA-1234159 ( R-HSA-1234176 ) R-HSA-1234159 Reaction Name: Proteasome proteolyzes ub-HIF-alpha See in Reactome R-HSA-1236935 ( R-HSA-1236974 ) R-HSA-1236935 Reaction Name: Proteasomal cleavage of substrate See in Reactome R-HSA-1236970 ( R-HSA-1236978 ) R-HSA-1236970 Reaction Name: Proteasomal clevage of exogenous antigen See in Reactome R-HSA-1504193 ( R-HSA-4641258 ) R-HSA-1504193 Reaction Name: Ubiquitinated DVL is degraded by the proteasome See in Reactome R-HSA-174058 ( R-HSA-174084 ) R-HSA-174058 Reaction Name: Degradation of multiubiquitinated Cdh1 See in Reactome R-HSA-174105 ( R-HSA-174178 ) R-HSA-174105 Reaction Name: Degradation of multiubiquitinated cell cycle proteins See in Reactome R-HSA-174202 ( R-HSA-174154; R-HSA-2467813 ) R-HSA-174202 Reaction Name: Degradation of multiubiquitinated Securin See in Reactome R-HSA-174203 ( R-HSA-174113 ) R-HSA-174203 Reaction Name: SCF-mediated degradation of Emi1 See in Reactome R-HSA-174255 ( R-HSA-174184 ) R-HSA-174255 Reaction Name: Degradation multiubiquitinated Cyclin A See in Reactome R-HSA-187574 ( R-HSA-187577 ) R-HSA-187574 Reaction Name: Degradation of ubiquitinated p27/p21 by the 26S proteasome See in Reactome R-HSA-188191 ( R-HSA-174178 ) R-HSA-188191 Reaction Name: APC/C:Cdh1-mediated degradation of Skp2 See in Reactome R-HSA-209061 ( R-HSA-9020702 ) R-HSA-209061 Reaction Name: Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex See in Reactome R-HSA-211715 ( R-HSA-211733 ) R-HSA-211715 Reaction Name: Proteasome mediated degradation of PAK-2p34 See in Reactome R-HSA-2130282 ( R-HSA-195253 ) R-HSA-2130282 Reaction Name: Degradation of ubiquitinated beta catenin by the proteasome See in Reactome R-HSA-264458 ( R-HSA-349425 ) R-HSA-264458 Reaction Name: Proteasome mediated degradation of COP1 See in Reactome R-HSA-353125 ( R-HSA-350562 ) R-HSA-353125 Reaction Name: 26S proteosome degrades ODC holoenzyme complex See in Reactome R-HSA-3640874 ( R-HSA-4641257 ) R-HSA-3640874 Reaction Name: Ub-RibC-AXIN is degraded by the proteasome See in Reactome R-HSA-450466 ( R-HSA-450408 ) R-HSA-450466 Reaction Name: AUF1:mRNA complex is destroyed See in Reactome R-HSA-4608855 ( R-HSA-4608870 ) R-HSA-4608855 Reaction Name: PRICKLE1 is degraded by the proteasome See in Reactome R-HSA-4641256 ( R-HSA-4641257 ) R-HSA-4641256 Reaction Name: Ubiquitinated AXIN is degraded by the proteasome See in Reactome R-HSA-4641260 ( R-HSA-4641258 ) R-HSA-4641260 Reaction Name: Ubiquitinated DVL1 is degraded by the proteasome See in Reactome R-HSA-5362448 ( R-HSA-5358346 ) R-HSA-5362448 Reaction Name: Hh C-terminal fragments are degraded by the proteasome See in Reactome R-HSA-5607724 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-5607724 Reaction Name: 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex See in Reactome R-HSA-5607731 ( R-HSA-5607761; R-HSA-5607764; R-HSA-5668541; R-HSA-5676590 ) R-HSA-5607731 Reaction Name: 26S proteasome processes p-7S-p100:RELB to form p52:RELB See in Reactome R-HSA-5610754 ( R-HSA-5610785 ) R-HSA-5610754 Reaction Name: GLI3 is partially degraded by the proteasome to yield the GLI3 repressor See in Reactome R-HSA-5610757 ( R-HSA-5610783 ) R-HSA-5610757 Reaction Name: GLI2 is degraded by the proteasome See in Reactome R-HSA-5610758 ( R-HSA-5610780 ) R-HSA-5610758 Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP See in Reactome R-HSA-5610760 ( R-HSA-5610780 ) R-HSA-5610760 Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by ITCH See in Reactome R-HSA-5635854 ( R-HSA-5632684 ) R-HSA-5635854 Reaction Name: GLI2,3 are degraded by the proteasome See in Reactome R-HSA-5635868 ( R-HSA-5632684 ) R-HSA-5635868 Reaction Name: ub-GLI is degraded by the proteasome See in Reactome R-HSA-5658430 ( R-HSA-5658442 ) R-HSA-5658430 Reaction Name: NF1 is degraded by the proteasome See in Reactome R-HSA-5665854 ( R-HSA-5689603 ) R-HSA-5665854 Reaction Name: ADRM1:26S proteaseome binds UCHL5 See in Reactome R-HSA-5665871 ( R-HSA-5689603 ) R-HSA-5665871 Reaction Name: ADRM1 binds 26S proteasome See in Reactome R-HSA-5668481 ( R-HSA-5668541 ) R-HSA-5668481 Reaction Name: Protesomal degradation of K48polyUb-TRAF3 See in Reactome R-HSA-5668520 ( R-HSA-5668541 ) R-HSA-5668520 Reaction Name: 26Sproteasome degrades K48polyUb-NIK See in Reactome R-HSA-5687112 ( R-HSA-5687128 ) R-HSA-5687112 Reaction Name: MAPK6 is degraded by the 26S proteasome See in Reactome R-HSA-5689539 ( R-HSA-5689880 ) R-HSA-5689539 Reaction Name: ADRM1:26S proteaseome binds USP14 See in Reactome R-HSA-68825 () R-HSA-68825 Reaction Name: Ubiquitinated geminin is degraded by the proteasome See in Reactome R-HSA-68948 ( R-HSA-68949 ) R-HSA-68948 Reaction Name: Ubiquitinated Orc1 is degraded by the proteasome See in Reactome R-HSA-69016 ( R-HSA-69017 ) R-HSA-69016 Reaction Name: Ubiquitinated Cdc6 is degraded by the proteasome See in Reactome R-HSA-69600 ( R-HSA-69601 ) R-HSA-69600 Reaction Name: Proteolytic degradation of ubiquitinated-Cdc25A See in Reactome R-HSA-75825 ( R-HSA-75815 ) R-HSA-75825 Reaction Name: Proteasome mediated degradation of Cyclin D1 See in Reactome R-HSA-8850992 ( R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8852354 ( R-HSA-69481; R-HSA-8852276 ) R-HSA-8852354 Reaction Name: GTSE1 facilitates proteasome-mediated degradation of TP53 See in Reactome R-HSA-8854044 ( R-HSA-8854050 ) R-HSA-8854044 Reaction Name: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 See in Reactome R-HSA-8854071 ( R-HSA-8854050 ) R-HSA-8854071 Reaction Name: Proteasome-mediated degradation of PolyUb-FBXL7 See in Reactome R-HSA-8866553 ( R-HSA-382556 ) R-HSA-8866553 Reaction Name: misfolded CFTR is degraded by the 26S proteasome See in Reactome R-HSA-8932355 ( R-HSA-8951664 ) R-HSA-8932355 Reaction Name: 26S proteasome degrades Ub-NFE2L2 See in Reactome R-HSA-8939801 ( R-HSA-8939902 ) R-HSA-8939801 Reaction Name: 26S proteasome degrades PolyUb-RUNX2 See in Reactome R-HSA-8952408 ( R-HSA-8941858 ) R-HSA-8952408 Reaction Name: Polyubiquitinated RUNX3 is degraded by the proteasome See in Reactome R-HSA-8956140 ( R-HSA-8951664 ) R-HSA-8956140 Reaction Name: NEDD8 and UBD bind NUB1 and the 26S proteasome See in Reactome R-HSA-8956184 ( R-HSA-8951664 ) R-HSA-8956184 Reaction Name: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates See in Reactome R-HSA-8957265 ( R-HSA-8939236 ) R-HSA-8957265 Reaction Name: 26S proteasome degrades TP73 polyubiquitinated by ITCH See in Reactome R-HSA-9008110 ( R-HSA-8939902 ) R-HSA-9008110 Reaction Name: Proteasome degrades polyubiquitinated RUNX2 See in Reactome R-HSA-9008475 ( R-HSA-8939902 ) R-HSA-9008475 Reaction Name: Proteasome degrades polyubiquitinated RUNX2 See in Reactome R-HSA-9009362 ( R-HSA-8939902 ) R-HSA-9009362 Reaction Name: Proteasome degrades PolyUb-RUNX2 See in Reactome R-HSA-9011313 ( R-HSA-9010553 ) R-HSA-9011313 Reaction Name: Proteasome degrades ubiquitinated ROBO3.1 See in Reactome R-HSA-9604642 ( R-HSA-9604323 ) R-HSA-9604642 Reaction Name: Proteasome degrades ubiquitinated NICD4 See in Reactome R-HSA-9755303 ( R-HSA-8951664 ) R-HSA-9755303 Reaction Name: 26S proteasome degrades HIFalpha See in Reactome R-HSA-9755306 ( R-HSA-8951664 ) R-HSA-9755306 Reaction Name: ub UBXN7 is degraded by the 26S proteasome See in Reactome R-HSA-9762096 () R-HSA-9762096 Reaction Name: Ub,pS335,S338,T NFE2L2 is degraded See in Reactome R-HSA-983150 ( R-HSA-983168 ) R-HSA-983150 Reaction Name: Proteasomal cleavage of substrate See in Reactome