DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-5362517)

Number of enzymes:	7
Number of disease:	8
Number of reactomes:	11
Number of reactions:	12

Search results (Reactome ID: R-HSA-5362517)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009502	DLAT	P10515	2.3.1.12	R-HSA-204174 R-HSA-204174 Reactome Name: Regulation of pyruvate dehydrogenase (PDH) complex See in Reactome R-HSA-389661 R-HSA-389661 Reactome Name: Glyoxylate metabolism and glycine degradation See in Reactome R-HSA-70268 R-HSA-70268 Reactome Name: Pyruvate metabolism See in Reactome R-HSA-5362517 R-HSA-5362517 Reactome Name: Signaling by Retinoic Acid See in Reactome	R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism Signal Transduction	R-HSA-203946 ( R-HSA-204174; R-HSA-5362517; R-HSA-70268 ) R-HSA-203946 Reaction Name: PDK isoforms phosphorylate lipo-PDH See in Reactome R-HSA-204169 ( R-HSA-204174; R-HSA-70268 ) R-HSA-204169 Reaction Name: PDP dephosphorylates p-lipo-PDH See in Reactome R-HSA-6792572 ( R-HSA-389661 ) R-HSA-6792572 Reaction Name: LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs See in Reactome R-HSA-71397 ( R-HSA-70268 ) R-HSA-71397 Reaction Name: lipo-PDH decarboxylates PYR to Ac-CoA See in Reactome
MONDO:0009529	DLD	P09622	1.8.1.4	R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome R-HSA-204174 R-HSA-204174 Reactome Name: Regulation of pyruvate dehydrogenase (PDH) complex See in Reactome R-HSA-70895 R-HSA-70895 Reactome Name: Branched-chain amino acid catabolism See in Reactome R-HSA-70268 R-HSA-70268 Reactome Name: Pyruvate metabolism See in Reactome R-HSA-71064 R-HSA-71064 Reactome Name: Lysine catabolism See in Reactome R-HSA-6783984 R-HSA-6783984 Reactome Name: Glycine degradation See in Reactome R-HSA-389661 R-HSA-389661 Reactome Name: Glyoxylate metabolism and glycine degradation See in Reactome R-HSA-5362517 R-HSA-5362517 Reactome Name: Signaling by Retinoic Acid See in Reactome	R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism Signal Transduction	R-HSA-203946 ( R-HSA-204174; R-HSA-5362517; R-HSA-70268 ) R-HSA-203946 Reaction Name: PDK isoforms phosphorylate lipo-PDH See in Reactome R-HSA-204169 ( R-HSA-204174; R-HSA-70268 ) R-HSA-204169 Reaction Name: PDP dephosphorylates p-lipo-PDH See in Reactome R-HSA-5693148 ( R-HSA-70895 ) R-HSA-5693148 Reaction Name: BCKDK phosphorylates BCKDH See in Reactome R-HSA-5693153 ( R-HSA-70895 ) R-HSA-5693153 Reaction Name: PPM1K dephosphorylates p-BCKDH See in Reactome R-HSA-5694018 ( R-HSA-389661; R-HSA-6783984 ) R-HSA-5694018 Reaction Name: DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate See in Reactome R-HSA-6792572 ( R-HSA-389661 ) R-HSA-6792572 Reaction Name: LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs See in Reactome R-HSA-70713 ( R-HSA-70895 ) R-HSA-70713 Reaction Name: BCKDH transfers CoA group from CoA-SH to BCAAs See in Reactome R-HSA-71037 ( R-HSA-71064 ) R-HSA-71037 Reaction Name: alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+ See in Reactome R-HSA-71397 ( R-HSA-70268 ) R-HSA-71397 Reaction Name: lipo-PDH decarboxylates PYR to Ac-CoA See in Reactome R-HSA-71401 ( R-HSA-71403 ) R-HSA-71401 Reaction Name: alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+ See in Reactome
MONDO:0009705	CPT1A	P50416	2.3.1.21	R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-200425 R-HSA-200425 Reactome Name: Carnitine metabolism See in Reactome R-HSA-5362517 R-HSA-5362517 Reactome Name: Signaling by Retinoic Acid See in Reactome R-HSA-1368082 R-HSA-1368082 Reactome Name: RORA activates gene expression See in Reactome	R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Circadian Clock Metabolism Signal Transduction	R-HSA-1801587 ( R-HSA-1368082; R-HSA-1989781 ) R-HSA-1801587 Reaction Name: Expression of CPT1A See in Reactome R-HSA-200406 ( R-HSA-200425; R-HSA-5362517 ) R-HSA-200406 Reaction Name: CPT1A,B transfers PALM to CAR See in Reactome
MONDO:0009776	PDHA2	P29803	1.2.4.1	R-HSA-204174 R-HSA-204174 Reactome Name: Regulation of pyruvate dehydrogenase (PDH) complex See in Reactome R-HSA-389661 R-HSA-389661 Reactome Name: Glyoxylate metabolism and glycine degradation See in Reactome R-HSA-70268 R-HSA-70268 Reactome Name: Pyruvate metabolism See in Reactome R-HSA-5362517 R-HSA-5362517 Reactome Name: Signaling by Retinoic Acid See in Reactome	R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism Signal Transduction	R-HSA-203946 ( R-HSA-204174; R-HSA-5362517; R-HSA-70268 ) R-HSA-203946 Reaction Name: PDK isoforms phosphorylate lipo-PDH See in Reactome R-HSA-204169 ( R-HSA-204174; R-HSA-70268 ) R-HSA-204169 Reaction Name: PDP dephosphorylates p-lipo-PDH See in Reactome R-HSA-6792572 ( R-HSA-389661 ) R-HSA-6792572 Reaction Name: LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs See in Reactome R-HSA-71397 ( R-HSA-70268 ) R-HSA-71397 Reaction Name: lipo-PDH decarboxylates PYR to Ac-CoA See in Reactome
MONDO:0010479	PDK3	Q15120	2.7.11.2	R-HSA-204174 R-HSA-204174 Reactome Name: Regulation of pyruvate dehydrogenase (PDH) complex See in Reactome R-HSA-5362517 R-HSA-5362517 Reactome Name: Signaling by Retinoic Acid See in Reactome	R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-70268 R-HSA-70268 Reactome Name: Pyruvate metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism Signal Transduction	R-HSA-203946 ( R-HSA-204174; R-HSA-5362517; R-HSA-70268 ) R-HSA-203946 Reaction Name: PDK isoforms phosphorylate lipo-PDH See in Reactome
MONDO:0010717	PDHA1	P08559	1.2.4.1	R-HSA-204174 R-HSA-204174 Reactome Name: Regulation of pyruvate dehydrogenase (PDH) complex See in Reactome R-HSA-389661 R-HSA-389661 Reactome Name: Glyoxylate metabolism and glycine degradation See in Reactome R-HSA-70268 R-HSA-70268 Reactome Name: Pyruvate metabolism See in Reactome R-HSA-5362517 R-HSA-5362517 Reactome Name: Signaling by Retinoic Acid See in Reactome	R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism Signal Transduction	R-HSA-203946 ( R-HSA-204174; R-HSA-5362517; R-HSA-70268 ) R-HSA-203946 Reaction Name: PDK isoforms phosphorylate lipo-PDH See in Reactome R-HSA-204169 ( R-HSA-204174; R-HSA-70268 ) R-HSA-204169 Reaction Name: PDP dephosphorylates p-lipo-PDH See in Reactome R-HSA-6792572 ( R-HSA-389661 ) R-HSA-6792572 Reaction Name: LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs See in Reactome R-HSA-71397 ( R-HSA-70268 ) R-HSA-71397 Reaction Name: lipo-PDH decarboxylates PYR to Ac-CoA See in Reactome
MONDO:0013580	PDHB	P11177	1.2.4.1	R-HSA-204174 R-HSA-204174 Reactome Name: Regulation of pyruvate dehydrogenase (PDH) complex See in Reactome R-HSA-389661 R-HSA-389661 Reactome Name: Glyoxylate metabolism and glycine degradation See in Reactome R-HSA-70268 R-HSA-70268 Reactome Name: Pyruvate metabolism See in Reactome R-HSA-5362517 R-HSA-5362517 Reactome Name: Signaling by Retinoic Acid See in Reactome	R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism Signal Transduction	R-HSA-203946 ( R-HSA-204174; R-HSA-5362517; R-HSA-70268 ) R-HSA-203946 Reaction Name: PDK isoforms phosphorylate lipo-PDH See in Reactome R-HSA-204169 ( R-HSA-204174; R-HSA-70268 ) R-HSA-204169 Reaction Name: PDP dephosphorylates p-lipo-PDH See in Reactome R-HSA-6792572 ( R-HSA-389661 ) R-HSA-6792572 Reaction Name: LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs See in Reactome R-HSA-71397 ( R-HSA-70268 ) R-HSA-71397 Reaction Name: lipo-PDH decarboxylates PYR to Ac-CoA See in Reactome
MONDO:0016815	PDHA1	P08559	1.2.4.1	R-HSA-204174 R-HSA-204174 Reactome Name: Regulation of pyruvate dehydrogenase (PDH) complex See in Reactome R-HSA-389661 R-HSA-389661 Reactome Name: Glyoxylate metabolism and glycine degradation See in Reactome R-HSA-70268 R-HSA-70268 Reactome Name: Pyruvate metabolism See in Reactome R-HSA-5362517 R-HSA-5362517 Reactome Name: Signaling by Retinoic Acid See in Reactome	R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism Signal Transduction	R-HSA-203946 ( R-HSA-204174; R-HSA-5362517; R-HSA-70268 ) R-HSA-203946 Reaction Name: PDK isoforms phosphorylate lipo-PDH See in Reactome R-HSA-204169 ( R-HSA-204174; R-HSA-70268 ) R-HSA-204169 Reaction Name: PDP dephosphorylates p-lipo-PDH See in Reactome R-HSA-6792572 ( R-HSA-389661 ) R-HSA-6792572 Reaction Name: LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs See in Reactome R-HSA-71397 ( R-HSA-70268 ) R-HSA-71397 Reaction Name: lipo-PDH decarboxylates PYR to Ac-CoA See in Reactome