MONDO:0007565 |
CYLD |
Q9NQC7 |
3.4.19.12
|
R-HSA-5357786
R-HSA-5357786
Reactome Name: TNFR1-induced proapoptotic signaling
See in Reactome
R-HSA-168638
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-936440
R-HSA-936440
Reactome Name: Negative regulators of DDX58/IFIH1 signaling
See in Reactome
R-HSA-5357905
|
R-HSA-5688426
R-HSA-168256
R-HSA-392499
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-73887
R-HSA-75893
R-HSA-168249
R-HSA-162582
|
Immune System
Metabolism of proteins
Signal Transduction
|
R-HSA-140978
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-140978
Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD
See in Reactome
R-HSA-5357776
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357831
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357845
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357860
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5357928
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357928
Reaction Name: CLIP3 and CYLD bind TNF signaling complex
See in Reactome
R-HSA-5696627
(
R-HSA-5689880
)
R-HSA-5696627
Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
See in Reactome
R-HSA-741411
(
R-HSA-168638
)
R-HSA-936390
(
R-HSA-5689880;
R-HSA-936440
)
R-HSA-936390
Reaction Name: CYLD mediated deubiquitination of DDX58 (RIG-I)
See in Reactome
|
MONDO:0008005 |
MAP3K7 |
O43318 |
2.7.11.25
|
R-HSA-9020702
R-HSA-450302
R-HSA-450302
Reactome Name: activated TAK1 mediates p38 MAPK activation
See in Reactome
R-HSA-202424
R-HSA-4086398
R-HSA-937042
R-HSA-937042
Reactome Name: IRAK2 mediated activation of TAK1 complex
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-168638
R-HSA-9645460
R-HSA-9645460
Reactome Name: Alpha-protein kinase 1 signaling pathway
See in Reactome
R-HSA-445989
R-HSA-445989
Reactome Name: TAK1-dependent IKK and NF-kappa-B activation
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-5607764
R-HSA-9014325
R-HSA-9014325
Reactome Name: TICAM1,TRAF6-dependent induction of TAK1 complex
See in Reactome
R-HSA-937072
R-HSA-937072
Reactome Name: TRAF6-mediated induction of TAK1 complex within TLR4 complex
See in Reactome
R-HSA-1169091
R-HSA-1169091
Reactome Name: Activation of NF-kappaB in B cells
See in Reactome
R-HSA-450321
R-HSA-450321
Reactome Name: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
See in Reactome
R-HSA-975163
R-HSA-975163
Reactome Name: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-449147
R-HSA-5688426
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-168898
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-73887
R-HSA-202403
R-HSA-446652
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-392499
R-HSA-166166
R-HSA-75893
R-HSA-450294
R-HSA-195721
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-448424
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-162582
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
|
Immune System
Metabolism of proteins
Signal Transduction
|
R-HSA-1168637
(
R-HSA-1169091
)
R-HSA-1168637
Reaction Name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK
See in Reactome
R-HSA-1168641
(
R-HSA-1169091
)
R-HSA-1168641
Reaction Name: TAK1 associated with the CBM complex phosphorylates IKKbeta
See in Reactome
R-HSA-168184
(
R-HSA-168638;
R-HSA-445989;
R-HSA-9020702
)
R-HSA-168184
Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex
See in Reactome
R-HSA-177690
(
R-HSA-9014325
)
R-HSA-177690
Reaction Name: Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex
See in Reactome
R-HSA-177692
(
R-HSA-9014325
)
R-HSA-177692
Reaction Name: Activation of recruited TAK1 within the activated TLR3 complex
See in Reactome
R-HSA-202500
(
R-HSA-202424
)
R-HSA-202510
(
R-HSA-202424
)
R-HSA-202510
Reaction Name: Activation of TAK1-TAB2 complex
See in Reactome
R-HSA-2730861
(
R-HSA-2871837
)
R-HSA-2730861
Reaction Name: Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6
See in Reactome
R-HSA-2730876
(
R-HSA-2871837
)
R-HSA-2730876
Reaction Name: Phosphorylation of IKK-beta by TAK1
See in Reactome
R-HSA-2730900
(
R-HSA-2871837
)
R-HSA-2730900
Reaction Name: Activation of TAK1 complex bound to pUb-TRAF6
See in Reactome
R-HSA-4332356
(
R-HSA-4086398
)
R-HSA-4332388
(
R-HSA-4086398
)
R-HSA-4332388
Reaction Name: Activation of MAP3K7 in response to WNT
See in Reactome
R-HSA-4411402
(
R-HSA-4086398
)
R-HSA-446870
(
R-HSA-9020702
)
R-HSA-446870
Reaction Name: Polyubiquitinated TRAF6 binds the TAK1 complex
See in Reactome
R-HSA-450187
(
R-HSA-9020702
)
R-HSA-450187
Reaction Name: TAK1 is activated within the TAK1 complex
See in Reactome
R-HSA-450337
(
R-HSA-450321
)
R-HSA-450337
Reaction Name: Activated TAK1 phosphorylates MKK4/MKK7
See in Reactome
R-HSA-450346
(
R-HSA-450302
)
R-HSA-450346
Reaction Name: activated human TAK1 phosphorylates MKK3/MKK6
See in Reactome
R-HSA-5357860
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5607732
(
R-HSA-5607764
)
R-HSA-5607732
Reaction Name: K63polyUb-TAK1 autophosphorylates
See in Reactome
R-HSA-5607742
(
R-HSA-5607764
)
R-HSA-5607742
Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
See in Reactome
R-HSA-5607757
(
R-HSA-5607764
)
R-HSA-5607757
Reaction Name: K63polyUb-TRAF6 ubiquitinates TAK1
See in Reactome
R-HSA-5607759
(
R-HSA-5607764
)
R-HSA-5607759
Reaction Name: TRIKA2 binds K63polyUb-TRAF6 oligomer
See in Reactome
R-HSA-5696534
(
R-HSA-5689880
)
R-HSA-5696534
Reaction Name: USP18 deubiquitinates TAK1:TAB1
See in Reactome
R-HSA-688985
(
R-HSA-168638
)
R-HSA-688985
Reaction Name: K63 polyubiquitinated RIP2 associates with the TAK1 complex
See in Reactome
R-HSA-706479
(
R-HSA-168638
)
R-HSA-727819
(
R-HSA-168638;
R-HSA-9020702
)
R-HSA-847070
(
R-HSA-9014325
)
R-HSA-847070
Reaction Name: Phosphorylated TAK1 dissociates from the TLR3 receptor complex
See in Reactome
R-HSA-936947
(
R-HSA-937072
)
R-HSA-936947
Reaction Name: Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex
See in Reactome
R-HSA-936951
(
R-HSA-937072
)
R-HSA-936951
Reaction Name: Activation of TAK1 complex bound to activated TLR4 complex
See in Reactome
R-HSA-936960
(
R-HSA-937042
)
R-HSA-936960
Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex
See in Reactome
R-HSA-936991
(
R-HSA-937042
)
R-HSA-936991
Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3
See in Reactome
R-HSA-937075
(
R-HSA-937072
)
R-HSA-937075
Reaction Name: Phosphorylated TAK1 leaves activated TLR receptor complex
See in Reactome
R-HSA-9645406
(
R-HSA-9645460
)
R-HSA-9645406
Reaction Name: ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)
See in Reactome
R-HSA-9645442
(
R-HSA-9645460
)
R-HSA-9645442
Reaction Name: Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex
See in Reactome
R-HSA-975097
(
R-HSA-975163
)
R-HSA-975097
Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-975103
(
R-HSA-975163
)
R-HSA-975103
Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation
See in Reactome
|
MONDO:0009292 |
RBCK1 |
Q9BYM8 |
2.3.2.31
|
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-5357905
|
R-HSA-168256
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-73887
R-HSA-75893
R-HSA-1280218
R-HSA-162582
|
Immune System
Signal Transduction
|
R-HSA-5357776
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357904
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357904
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
See in Reactome
R-HSA-5661517
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-983140
(
R-HSA-983168
)
R-HSA-983140
Reaction Name: Transfer of Ub from E2 to substrate and release of E2
See in Reactome
R-HSA-983147
(
R-HSA-983168
)
R-HSA-983147
Reaction Name: Release of E3 from polyubiquitinated substrate
See in Reactome
R-HSA-983156
(
R-HSA-983168
)
R-HSA-983156
Reaction Name: Polyubiquitination of substrate
See in Reactome
R-HSA-983157
(
R-HSA-983168
)
R-HSA-983157
Reaction Name: Interaction of E3 with substrate and E2-Ub complex
See in Reactome
|
MONDO:0010385 |
XIAP |
P98170 |
2.3.2.27
|
R-HSA-111469
R-HSA-111469
Reactome Name: SMAC, XIAP-regulated apoptotic response
See in Reactome
R-HSA-5675482
R-HSA-5675482
Reactome Name: Regulation of necroptotic cell death
See in Reactome
R-HSA-9627069
R-HSA-9627069
Reactome Name: Regulation of the apoptosome activity
See in Reactome
R-HSA-111464
R-HSA-111464
Reactome Name: SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
See in Reactome
R-HSA-5213460
R-HSA-5213460
Reactome Name: RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-111463
R-HSA-5357905
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111459
R-HSA-111459
Reactome Name: Activation of caspases through apoptosome-mediated cleavage
See in Reactome
|
R-HSA-195721
R-HSA-1257604
R-HSA-6807070
R-HSA-111461
R-HSA-111461
Reactome Name: Cytochrome c-mediated apoptotic response
See in Reactome
R-HSA-5357801
R-HSA-5218859
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-111471
R-HSA-111471
Reactome Name: Apoptotic factor-mediated response
See in Reactome
R-HSA-109581
R-HSA-73887
R-HSA-75893
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-111458
R-HSA-162582
|
Programmed Cell Death
Signal Transduction
|
R-HSA-114252
(
R-HSA-111459
)
R-HSA-114252
Reaction Name: Cleavage of Procaspase-3 by the apoptosome
See in Reactome
R-HSA-114261
(
R-HSA-111459
)
R-HSA-114261
Reaction Name: Cleavage of Procaspase-7 by the apoptosome
See in Reactome
R-HSA-114306
(
R-HSA-111463;
R-HSA-111469
)
R-HSA-114354
(
R-HSA-111463;
R-HSA-111469
)
R-HSA-114361
(
R-HSA-111463;
R-HSA-111469
)
R-HSA-114361
Reaction Name: SMAC binds XIAP within apoptosome
See in Reactome
R-HSA-114392
(
R-HSA-111464;
R-HSA-111469
)
R-HSA-114392
Reaction Name: Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7
See in Reactome
R-HSA-114419
(
R-HSA-111464;
R-HSA-111469
)
R-HSA-114419
Reaction Name: Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3
See in Reactome
R-HSA-114440
(
R-HSA-111464;
R-HSA-111469
)
R-HSA-114440
Reaction Name: Dissociation of DIABLO:XIAP from the apoptosome complex
See in Reactome
R-HSA-3322429
(
R-HSA-3769402
)
R-HSA-3322431
(
R-HSA-3769402
)
R-HSA-3322434
(
R-HSA-3769402
)
R-HSA-5213462
(
R-HSA-5213460
)
R-HSA-5357757
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357757
Reaction Name: BIRC(cIAP1/2) ubiquitinates RIPK1
See in Reactome
R-HSA-5357776
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357780
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357780
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2)
See in Reactome
R-HSA-5357845
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357860
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5357904
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357904
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
See in Reactome
R-HSA-5357928
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357928
Reaction Name: CLIP3 and CYLD bind TNF signaling complex
See in Reactome
R-HSA-5675470
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-5675470
Reaction Name: BIRC2/3 (cIAP1/2) is autoubiquitinated
See in Reactome
R-HSA-5693055
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5693055
Reaction Name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes
See in Reactome
R-HSA-5693108
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5693108
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains
See in Reactome
R-HSA-6807106
(
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807134
(
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-9627078
(
R-HSA-9627069
)
R-HSA-9627104
(
R-HSA-111469
)
R-HSA-9627107
(
R-HSA-111469
)
R-HSA-9627350
(
R-HSA-111463;
R-HSA-111469
)
R-HSA-9627369
(
R-HSA-111469
)
|
MONDO:0013334 |
CHUK |
O15111 |
2.7.11.10
|
R-HSA-5684264
R-HSA-5684264
Reactome Name: MAP3K8 (TPL2)-dependent MAPK1/3 activation
See in Reactome
R-HSA-9020702
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-937039
R-HSA-202424
R-HSA-5607761
R-HSA-5607761
Reactome Name: Dectin-1 mediated noncanonical NF-kB signaling
See in Reactome
R-HSA-933542
R-HSA-933542
Reactome Name: TRAF6 mediated NF-kB activation
See in Reactome
R-HSA-937041
R-HSA-937041
Reactome Name: IKK complex recruitment mediated by RIP1
See in Reactome
R-HSA-168638
R-HSA-1236974
R-HSA-5357905
R-HSA-975144
R-HSA-975144
Reactome Name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-445989
R-HSA-445989
Reactome Name: TAK1-dependent IKK and NF-kappa-B activation
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-1810476
R-HSA-1810476
Reactome Name: RIP-mediated NFkB activation via ZBP1
See in Reactome
R-HSA-5676590
R-HSA-5676590
Reactome Name: NIK-->noncanonical NF-kB signaling
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-5607764
R-HSA-1169091
R-HSA-1169091
Reactome Name: Activation of NF-kappaB in B cells
See in Reactome
R-HSA-168927
R-HSA-168927
Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment
See in Reactome
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-449147
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-1280218
R-HSA-5668541
R-HSA-5668541
Reactome Name: TNFR2 non-canonical NF-kB pathway
See in Reactome
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-1257604
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-168898
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-73887
R-HSA-1606322
R-HSA-1606322
Reactome Name: ZBP1(DAI) mediated induction of type I IFNs
See in Reactome
R-HSA-202403
R-HSA-446652
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-166166
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
R-HSA-75893
R-HSA-450294
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-448424
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-162582
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
|
Immune System
Signal Transduction
|
R-HSA-1168637
(
R-HSA-1169091
)
R-HSA-1168637
Reaction Name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK
See in Reactome
R-HSA-1168638
(
R-HSA-1169091
)
R-HSA-1168638
Reaction Name: Activated IKK phosphorylates I-kappaB
See in Reactome
R-HSA-1168641
(
R-HSA-1169091
)
R-HSA-1168641
Reaction Name: TAK1 associated with the CBM complex phosphorylates IKKbeta
See in Reactome
R-HSA-168140
(
R-HSA-1810476;
R-HSA-445989;
R-HSA-9020702;
R-HSA-933542
)
R-HSA-168140
Reaction Name: Active IKK Complex phosphorylates NF-kappa-B inhibitor
See in Reactome
R-HSA-168184
(
R-HSA-168638;
R-HSA-445989;
R-HSA-9020702
)
R-HSA-168184
Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex
See in Reactome
R-HSA-168910
(
R-HSA-1810476
)
R-HSA-168910
Reaction Name: RIP1 facilitates IKK complex phosphorylation
See in Reactome
R-HSA-198611
(
R-HSA-198323
)
R-HSA-202500
(
R-HSA-202424
)
R-HSA-202534
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-202534
Reaction Name: Ubiquitination of NEMO by TRAF6
See in Reactome
R-HSA-202541
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-202541
Reaction Name: p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB
See in Reactome
R-HSA-2730876
(
R-HSA-2871837
)
R-HSA-2730876
Reaction Name: Phosphorylation of IKK-beta by TAK1
See in Reactome
R-HSA-451561
(
R-HSA-9020702
)
R-HSA-451561
Reaction Name: NEMO binds polyubiquitinated IRAK1
See in Reactome
R-HSA-5357776
(
R-HSA-5357956
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357831
(
R-HSA-5357905
)
R-HSA-5607720
(
R-HSA-5607761;
R-HSA-5607764;
R-HSA-5676590
)
R-HSA-5607720
Reaction Name: p100:RELB binds active NIK:p-IKKA dimer
See in Reactome
R-HSA-5607722
(
R-HSA-5607761;
R-HSA-5607764;
R-HSA-5676590
)
R-HSA-5607722
Reaction Name: Active NIK phosphorylates IKKA dimer
See in Reactome
R-HSA-5607723
(
R-HSA-5607761;
R-HSA-5607764;
R-HSA-5676590
)
R-HSA-5607723
Reaction Name: SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB
See in Reactome
R-HSA-5607725
(
R-HSA-5607761;
R-HSA-5607764;
R-HSA-5676590
)
R-HSA-5607725
Reaction Name: SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP
See in Reactome
R-HSA-5607726
(
R-HSA-5607761;
R-HSA-5607764;
R-HSA-5676590
)
R-HSA-5607726
Reaction Name: Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB
See in Reactome
R-HSA-5607742
(
R-HSA-5607764
)
R-HSA-5607742
Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
See in Reactome
R-HSA-5609665
(
R-HSA-445989;
R-HSA-9020702
)
R-HSA-5609665
Reaction Name: CHUK, IKBKB and IKBKG form IKK complex
See in Reactome
R-HSA-5626962
(
R-HSA-5357905
)
R-HSA-5684267
(
R-HSA-5684264;
R-HSA-9020702
)
R-HSA-5684267
Reaction Name: IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex
See in Reactome
R-HSA-5684275
(
R-HSA-5684264;
R-HSA-9020702
)
R-HSA-5684275
Reaction Name: IKBKB phosphorylates TPL2 (MAP3K8) at Ser400
See in Reactome
R-HSA-8863895
(
R-HSA-1236974
)
R-HSA-9014343
(
R-HSA-168927
)
R-HSA-9014343
Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex
See in Reactome
R-HSA-933530
(
R-HSA-933542
)
R-HSA-933539
(
R-HSA-933543
)
R-HSA-937029
(
R-HSA-937041
)
R-HSA-937029
Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1
See in Reactome
R-HSA-937032
(
R-HSA-937039
)
R-HSA-937032
Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1
See in Reactome
R-HSA-975119
(
R-HSA-975144
)
R-HSA-975119
Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9.
See in Reactome
|
MONDO:0014267 |
IKBKB |
O14920 |
2.7.11.10
2.7.11.1
|
R-HSA-5684264
R-HSA-5684264
Reactome Name: MAP3K8 (TPL2)-dependent MAPK1/3 activation
See in Reactome
R-HSA-9020702
R-HSA-937039
R-HSA-202424
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-933542
R-HSA-933542
Reactome Name: TRAF6 mediated NF-kB activation
See in Reactome
R-HSA-937041
R-HSA-937041
Reactome Name: IKK complex recruitment mediated by RIP1
See in Reactome
R-HSA-168638
R-HSA-1236974
R-HSA-5357905
R-HSA-975144
R-HSA-975144
Reactome Name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-445989
R-HSA-445989
Reactome Name: TAK1-dependent IKK and NF-kappa-B activation
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-1810476
R-HSA-1810476
Reactome Name: RIP-mediated NFkB activation via ZBP1
See in Reactome
R-HSA-209543
R-HSA-209543
Reactome Name: p75NTR recruits signalling complexes
See in Reactome
R-HSA-209560
R-HSA-209560
Reactome Name: NF-kB is activated and signals survival
See in Reactome
R-HSA-5607764
R-HSA-1169091
R-HSA-1169091
Reactome Name: Activation of NF-kappaB in B cells
See in Reactome
R-HSA-168927
R-HSA-168927
Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment
See in Reactome
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-449147
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-1280218
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-168898
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-73887
R-HSA-1606322
R-HSA-1606322
Reactome Name: ZBP1(DAI) mediated induction of type I IFNs
See in Reactome
R-HSA-202403
R-HSA-446652
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-193639
R-HSA-166166
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
R-HSA-75893
R-HSA-450294
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-448424
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-162582
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
|
Immune System
Signal Transduction
|
R-HSA-1168637
(
R-HSA-1169091
)
R-HSA-1168637
Reaction Name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK
See in Reactome
R-HSA-1168638
(
R-HSA-1169091
)
R-HSA-1168638
Reaction Name: Activated IKK phosphorylates I-kappaB
See in Reactome
R-HSA-1168641
(
R-HSA-1169091
)
R-HSA-1168641
Reaction Name: TAK1 associated with the CBM complex phosphorylates IKKbeta
See in Reactome
R-HSA-168140
(
R-HSA-1810476;
R-HSA-445989;
R-HSA-9020702;
R-HSA-933542
)
R-HSA-168140
Reaction Name: Active IKK Complex phosphorylates NF-kappa-B inhibitor
See in Reactome
R-HSA-168184
(
R-HSA-168638;
R-HSA-445989;
R-HSA-9020702
)
R-HSA-168184
Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex
See in Reactome
R-HSA-168910
(
R-HSA-1810476
)
R-HSA-168910
Reaction Name: RIP1 facilitates IKK complex phosphorylation
See in Reactome
R-HSA-193641
(
R-HSA-209543
)
R-HSA-193703
(
R-HSA-209560
)
R-HSA-193705
(
R-HSA-209560
)
R-HSA-193705
Reaction Name: IKKbeta phosphorylates IkB causing NF-kB to dissociate
See in Reactome
R-HSA-202500
(
R-HSA-202424
)
R-HSA-202534
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-202534
Reaction Name: Ubiquitination of NEMO by TRAF6
See in Reactome
R-HSA-202541
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-202541
Reaction Name: p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB
See in Reactome
R-HSA-209087
(
R-HSA-9020702
)
R-HSA-209087
Reaction Name: IKBA is phosphorylated by Phospho IKKB kinase
See in Reactome
R-HSA-2730876
(
R-HSA-2871837
)
R-HSA-2730876
Reaction Name: Phosphorylation of IKK-beta by TAK1
See in Reactome
R-HSA-451561
(
R-HSA-9020702
)
R-HSA-451561
Reaction Name: NEMO binds polyubiquitinated IRAK1
See in Reactome
R-HSA-5357776
(
R-HSA-5357956
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357831
(
R-HSA-5357905
)
R-HSA-5607742
(
R-HSA-5607764
)
R-HSA-5607742
Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
See in Reactome
R-HSA-5609665
(
R-HSA-445989;
R-HSA-9020702
)
R-HSA-5609665
Reaction Name: CHUK, IKBKB and IKBKG form IKK complex
See in Reactome
R-HSA-5626962
(
R-HSA-5357905
)
R-HSA-5684267
(
R-HSA-5684264;
R-HSA-9020702
)
R-HSA-5684267
Reaction Name: IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex
See in Reactome
R-HSA-5684275
(
R-HSA-5684264;
R-HSA-9020702
)
R-HSA-5684275
Reaction Name: IKBKB phosphorylates TPL2 (MAP3K8) at Ser400
See in Reactome
R-HSA-8863895
(
R-HSA-1236974
)
R-HSA-9014343
(
R-HSA-168927
)
R-HSA-9014343
Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex
See in Reactome
R-HSA-933530
(
R-HSA-933542
)
R-HSA-933539
(
R-HSA-933543
)
R-HSA-937029
(
R-HSA-937041
)
R-HSA-937029
Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1
See in Reactome
R-HSA-937032
(
R-HSA-937039
)
R-HSA-937032
Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1
See in Reactome
R-HSA-975119
(
R-HSA-975144
)
R-HSA-975119
Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9.
See in Reactome
|
MONDO:0014389 |
RBCK1 |
Q9BYM8 |
2.3.2.31
|
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-5357905
|
R-HSA-168256
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-73887
R-HSA-75893
R-HSA-1280218
R-HSA-162582
|
Immune System
Signal Transduction
|
R-HSA-5357776
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357904
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357904
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
See in Reactome
R-HSA-5661517
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-983140
(
R-HSA-983168
)
R-HSA-983140
Reaction Name: Transfer of Ub from E2 to substrate and release of E2
See in Reactome
R-HSA-983147
(
R-HSA-983168
)
R-HSA-983147
Reaction Name: Release of E3 from polyubiquitinated substrate
See in Reactome
R-HSA-983156
(
R-HSA-983168
)
R-HSA-983156
Reaction Name: Polyubiquitination of substrate
See in Reactome
R-HSA-983157
(
R-HSA-983168
)
R-HSA-983157
Reaction Name: Interaction of E3 with substrate and E2-Ub complex
See in Reactome
|
MONDO:0014761 |
TNFAIP3 |
P21580 |
2.3.2.-
3.4.19.12
|
R-HSA-5357786
R-HSA-5357786
Reactome Name: TNFR1-induced proapoptotic signaling
See in Reactome
R-HSA-168638
R-HSA-5357905
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-936440
R-HSA-936440
Reactome Name: Negative regulators of DDX58/IFIH1 signaling
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
|
R-HSA-5688426
R-HSA-168256
R-HSA-392499
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-73887
R-HSA-75893
R-HSA-168249
R-HSA-162582
|
Immune System
Metabolism of proteins
Signal Transduction
|
R-HSA-140978
(
R-HSA-5357786
)
R-HSA-140978
Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD
See in Reactome
R-HSA-5357776
(
R-HSA-5357956
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357845
(
R-HSA-5357905
)
R-HSA-5357860
(
R-HSA-5357956
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5690827
(
R-HSA-5689896
)
R-HSA-5690827
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1
See in Reactome
R-HSA-5690845
(
R-HSA-5689896
)
R-HSA-5690856
(
R-HSA-5689896
)
R-HSA-5690856
Reaction Name: TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1
See in Reactome
R-HSA-5690870
(
R-HSA-5689896
)
R-HSA-5690870
Reaction Name: OTUD7B,TNFAIP3 deubiquitinate TRAF6
See in Reactome
R-HSA-5693055
(
R-HSA-5357905
)
R-HSA-5693055
Reaction Name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes
See in Reactome
R-HSA-5693108
(
R-HSA-5357905
)
R-HSA-5693108
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains
See in Reactome
R-HSA-688136
(
R-HSA-168638;
R-HSA-5689896
)
R-HSA-688136
Reaction Name: TNFAIP3 (A20) deubiquitinates RIP2
See in Reactome
R-HSA-8869506
(
R-HSA-5689896
)
R-HSA-8869506
Reaction Name: TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6
See in Reactome
R-HSA-937337
(
R-HSA-936440
)
R-HSA-937337
Reaction Name: TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination
See in Reactome
|
MONDO:0014935 |
MAP3K7 |
O43318 |
2.7.11.25
|
R-HSA-9020702
R-HSA-450302
R-HSA-450302
Reactome Name: activated TAK1 mediates p38 MAPK activation
See in Reactome
R-HSA-202424
R-HSA-4086398
R-HSA-937042
R-HSA-937042
Reactome Name: IRAK2 mediated activation of TAK1 complex
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-168638
R-HSA-9645460
R-HSA-9645460
Reactome Name: Alpha-protein kinase 1 signaling pathway
See in Reactome
R-HSA-445989
R-HSA-445989
Reactome Name: TAK1-dependent IKK and NF-kappa-B activation
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-5607764
R-HSA-9014325
R-HSA-9014325
Reactome Name: TICAM1,TRAF6-dependent induction of TAK1 complex
See in Reactome
R-HSA-937072
R-HSA-937072
Reactome Name: TRAF6-mediated induction of TAK1 complex within TLR4 complex
See in Reactome
R-HSA-1169091
R-HSA-1169091
Reactome Name: Activation of NF-kappaB in B cells
See in Reactome
R-HSA-450321
R-HSA-450321
Reactome Name: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
See in Reactome
R-HSA-975163
R-HSA-975163
Reactome Name: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-449147
R-HSA-5688426
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-168898
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-73887
R-HSA-202403
R-HSA-446652
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-392499
R-HSA-166166
R-HSA-75893
R-HSA-450294
R-HSA-195721
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-448424
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-162582
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
|
Immune System
Metabolism of proteins
Signal Transduction
|
R-HSA-1168637
(
R-HSA-1169091
)
R-HSA-1168637
Reaction Name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK
See in Reactome
R-HSA-1168641
(
R-HSA-1169091
)
R-HSA-1168641
Reaction Name: TAK1 associated with the CBM complex phosphorylates IKKbeta
See in Reactome
R-HSA-168184
(
R-HSA-168638;
R-HSA-445989;
R-HSA-9020702
)
R-HSA-168184
Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex
See in Reactome
R-HSA-177690
(
R-HSA-9014325
)
R-HSA-177690
Reaction Name: Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex
See in Reactome
R-HSA-177692
(
R-HSA-9014325
)
R-HSA-177692
Reaction Name: Activation of recruited TAK1 within the activated TLR3 complex
See in Reactome
R-HSA-202500
(
R-HSA-202424
)
R-HSA-202510
(
R-HSA-202424
)
R-HSA-202510
Reaction Name: Activation of TAK1-TAB2 complex
See in Reactome
R-HSA-2730861
(
R-HSA-2871837
)
R-HSA-2730861
Reaction Name: Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6
See in Reactome
R-HSA-2730876
(
R-HSA-2871837
)
R-HSA-2730876
Reaction Name: Phosphorylation of IKK-beta by TAK1
See in Reactome
R-HSA-2730900
(
R-HSA-2871837
)
R-HSA-2730900
Reaction Name: Activation of TAK1 complex bound to pUb-TRAF6
See in Reactome
R-HSA-4332356
(
R-HSA-4086398
)
R-HSA-4332388
(
R-HSA-4086398
)
R-HSA-4332388
Reaction Name: Activation of MAP3K7 in response to WNT
See in Reactome
R-HSA-4411402
(
R-HSA-4086398
)
R-HSA-446870
(
R-HSA-9020702
)
R-HSA-446870
Reaction Name: Polyubiquitinated TRAF6 binds the TAK1 complex
See in Reactome
R-HSA-450187
(
R-HSA-9020702
)
R-HSA-450187
Reaction Name: TAK1 is activated within the TAK1 complex
See in Reactome
R-HSA-450337
(
R-HSA-450321
)
R-HSA-450337
Reaction Name: Activated TAK1 phosphorylates MKK4/MKK7
See in Reactome
R-HSA-450346
(
R-HSA-450302
)
R-HSA-450346
Reaction Name: activated human TAK1 phosphorylates MKK3/MKK6
See in Reactome
R-HSA-5357860
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5607732
(
R-HSA-5607764
)
R-HSA-5607732
Reaction Name: K63polyUb-TAK1 autophosphorylates
See in Reactome
R-HSA-5607742
(
R-HSA-5607764
)
R-HSA-5607742
Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
See in Reactome
R-HSA-5607757
(
R-HSA-5607764
)
R-HSA-5607757
Reaction Name: K63polyUb-TRAF6 ubiquitinates TAK1
See in Reactome
R-HSA-5607759
(
R-HSA-5607764
)
R-HSA-5607759
Reaction Name: TRIKA2 binds K63polyUb-TRAF6 oligomer
See in Reactome
R-HSA-5696534
(
R-HSA-5689880
)
R-HSA-5696534
Reaction Name: USP18 deubiquitinates TAK1:TAB1
See in Reactome
R-HSA-688985
(
R-HSA-168638
)
R-HSA-688985
Reaction Name: K63 polyubiquitinated RIP2 associates with the TAK1 complex
See in Reactome
R-HSA-706479
(
R-HSA-168638
)
R-HSA-727819
(
R-HSA-168638;
R-HSA-9020702
)
R-HSA-847070
(
R-HSA-9014325
)
R-HSA-847070
Reaction Name: Phosphorylated TAK1 dissociates from the TLR3 receptor complex
See in Reactome
R-HSA-936947
(
R-HSA-937072
)
R-HSA-936947
Reaction Name: Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex
See in Reactome
R-HSA-936951
(
R-HSA-937072
)
R-HSA-936951
Reaction Name: Activation of TAK1 complex bound to activated TLR4 complex
See in Reactome
R-HSA-936960
(
R-HSA-937042
)
R-HSA-936960
Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex
See in Reactome
R-HSA-936991
(
R-HSA-937042
)
R-HSA-936991
Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3
See in Reactome
R-HSA-937075
(
R-HSA-937072
)
R-HSA-937075
Reaction Name: Phosphorylated TAK1 leaves activated TLR receptor complex
See in Reactome
R-HSA-9645406
(
R-HSA-9645460
)
R-HSA-9645406
Reaction Name: ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)
See in Reactome
R-HSA-9645442
(
R-HSA-9645460
)
R-HSA-9645442
Reaction Name: Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex
See in Reactome
R-HSA-975097
(
R-HSA-975163
)
R-HSA-975097
Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-975103
(
R-HSA-975163
)
R-HSA-975103
Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation
See in Reactome
|
MONDO:0017992 |
RNF31 |
Q96EP0 |
2.3.2.31
|
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-5357905
|
R-HSA-73887
R-HSA-75893
R-HSA-162582
|
Signal Transduction
|
R-HSA-5357776
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357904
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357904
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
See in Reactome
R-HSA-5661517
(
R-HSA-5357905;
R-HSA-75893
)
|
MONDO:0017992 |
RBCK1 |
Q9BYM8 |
2.3.2.31
|
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-5357905
|
R-HSA-168256
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-73887
R-HSA-75893
R-HSA-1280218
R-HSA-162582
|
Immune System
Signal Transduction
|
R-HSA-5357776
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357904
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357904
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
See in Reactome
R-HSA-5661517
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-983140
(
R-HSA-983168
)
R-HSA-983140
Reaction Name: Transfer of Ub from E2 to substrate and release of E2
See in Reactome
R-HSA-983147
(
R-HSA-983168
)
R-HSA-983147
Reaction Name: Release of E3 from polyubiquitinated substrate
See in Reactome
R-HSA-983156
(
R-HSA-983168
)
R-HSA-983156
Reaction Name: Polyubiquitination of substrate
See in Reactome
R-HSA-983157
(
R-HSA-983168
)
R-HSA-983157
Reaction Name: Interaction of E3 with substrate and E2-Ub complex
See in Reactome
|
MONDO:0018348 |
RBCK1 |
Q9BYM8 |
2.3.2.31
|
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-5357905
|
R-HSA-168256
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-73887
R-HSA-75893
R-HSA-1280218
R-HSA-162582
|
Immune System
Signal Transduction
|
R-HSA-5357776
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357904
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357904
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
See in Reactome
R-HSA-5661517
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-983140
(
R-HSA-983168
)
R-HSA-983140
Reaction Name: Transfer of Ub from E2 to substrate and release of E2
See in Reactome
R-HSA-983147
(
R-HSA-983168
)
R-HSA-983147
Reaction Name: Release of E3 from polyubiquitinated substrate
See in Reactome
R-HSA-983156
(
R-HSA-983168
)
R-HSA-983156
Reaction Name: Polyubiquitination of substrate
See in Reactome
R-HSA-983157
(
R-HSA-983168
)
R-HSA-983157
Reaction Name: Interaction of E3 with substrate and E2-Ub complex
See in Reactome
|
MONDO:0020849 |
RIPK1 |
Q13546 |
2.7.11.1
|
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-3295583
R-HSA-168927
R-HSA-168927
Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment
See in Reactome
R-HSA-9686347
R-HSA-9686347
Reactome Name: Microbial modulation of RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-937041
R-HSA-937041
Reactome Name: IKK complex recruitment mediated by RIP1
See in Reactome
R-HSA-5213460
R-HSA-5213460
Reactome Name: RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5357905
R-HSA-5218900
R-HSA-140534
R-HSA-140534
Reactome Name: Caspase activation via Death Receptors in the presence of ligand
See in Reactome
R-HSA-2562578
R-HSA-2562578
Reactome Name: TRIF-mediated programmed cell death
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-1810476
R-HSA-1810476
Reactome Name: RIP-mediated NFkB activation via ZBP1
See in Reactome
R-HSA-69416
R-HSA-5675482
R-HSA-5675482
Reactome Name: Regulation of necroptotic cell death
See in Reactome
R-HSA-75893
R-HSA-3371378
R-HSA-5357786
R-HSA-5357786
Reactome Name: TNFR1-induced proapoptotic signaling
See in Reactome
R-HSA-9013957
R-HSA-9013957
Reactome Name: TLR3-mediated TICAM1-dependent programmed cell death
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-168256
R-HSA-382551
R-HSA-5357801
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168898
R-HSA-166166
R-HSA-1606322
R-HSA-1606322
Reactome Name: ZBP1(DAI) mediated induction of type I IFNs
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-983712
R-HSA-5357769
R-HSA-5357769
Reactome Name: Caspase activation via extrinsic apoptotic signalling pathway
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-5218859
R-HSA-73887
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
R-HSA-5688426
R-HSA-109581
R-HSA-2672351
R-HSA-162582
|
Immune System
Transport of small molecules
Programmed Cell Death
Metabolism of proteins
Signal Transduction
|
R-HSA-139952
(
R-HSA-140534
)
R-HSA-139952
Reaction Name: Caspase-8 processing in the DISC
See in Reactome
R-HSA-140978
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-140978
Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD
See in Reactome
R-HSA-141159
(
R-HSA-140534;
R-HSA-69416
)
R-HSA-141159
Reaction Name: TNF-mediated dimerization of procaspase-8
See in Reactome
R-HSA-168910
(
R-HSA-1810476
)
R-HSA-168910
Reaction Name: RIP1 facilitates IKK complex phosphorylation
See in Reactome
R-HSA-168915
(
R-HSA-937041
)
R-HSA-168915
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-168921
(
R-HSA-937041
)
R-HSA-168921
Reaction Name: TRIF:activated TLR3/TLR4 complex recruits RIP1
See in Reactome
R-HSA-168930
(
R-HSA-168927
)
R-HSA-168930
Reaction Name: Viral dsRNA:TLR3:TRIF complex recruits RIP1
See in Reactome
R-HSA-168934
(
R-HSA-933543
)
R-HSA-168934
Reaction Name: MAVS interacts with RIPK1 and FADD
See in Reactome
R-HSA-1810457
(
R-HSA-1810476
)
R-HSA-1810457
Reaction Name: ZBP1(DAI) recruits RIP1 and RIP3
See in Reactome
R-HSA-2562541
(
R-HSA-2562578
)
R-HSA-2562541
Reaction Name: TLR4-induced ripoptosome assembly
See in Reactome
R-HSA-2562564
(
R-HSA-140534;
R-HSA-2562578
)
R-HSA-2562564
Reaction Name: Caspase-8 processing within TLR4 complex
See in Reactome
R-HSA-2569057
(
R-HSA-2562578
)
R-HSA-2569057
Reaction Name: RIP3 binds TRIF to mediate necroptosis
See in Reactome
R-HSA-3295579
(
R-HSA-3295583
)
R-HSA-3295579
Reaction Name: TRPs transport extracellular Ca2+ to cytosol
See in Reactome
R-HSA-3371360
(
R-HSA-140534;
R-HSA-3371378;
R-HSA-5357905;
R-HSA-75893
)
R-HSA-3371360
Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling
See in Reactome
R-HSA-3465429
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5675482
)
R-HSA-3465429
Reaction Name: FLIP(S) and procaspase-8 form heterodimer
See in Reactome
R-HSA-3465448
(
R-HSA-140534;
R-HSA-3371378
)
R-HSA-3465448
Reaction Name: Caspase-8 and FLIP(L) processing at DISC
See in Reactome
R-HSA-5213462
(
R-HSA-5213460
)
R-HSA-5213464
(
R-HSA-5213460
)
R-HSA-5213466
(
R-HSA-5213460
)
R-HSA-5218891
(
R-HSA-5213460
)
R-HSA-5218891
Reaction Name: RIPK1:RIPK3 oligomer binds MLKL
See in Reactome
R-HSA-5218905
(
R-HSA-5213460
)
R-HSA-5218905
Reaction Name: RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils
See in Reactome
R-HSA-5218906
(
R-HSA-5213460
)
R-HSA-5357757
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357757
Reaction Name: BIRC(cIAP1/2) ubiquitinates RIPK1
See in Reactome
R-HSA-5357776
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357780
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357780
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2)
See in Reactome
R-HSA-5357828
(
R-HSA-5213460;
R-HSA-5357905;
R-HSA-5675482;
R-HSA-75893
)
R-HSA-5357845
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357860
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5357904
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357904
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
See in Reactome
R-HSA-5357927
(
R-HSA-5213460
)
R-HSA-5357928
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357928
Reaction Name: CLIP3 and CYLD bind TNF signaling complex
See in Reactome
R-HSA-5620975
(
R-HSA-5213460
)
R-HSA-5634221
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5634221
Reaction Name: TRAF1 binds TRAF2 within TNFR1 signaling complex
See in Reactome
R-HSA-5675456
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5675482
)
R-HSA-5675456
Reaction Name: FLIP(L) and procaspase-8 form heterodimer
See in Reactome
R-HSA-5690159
(
R-HSA-5689880
)
R-HSA-5690159
Reaction Name: USP21 deubiquitinates RIPK1,DDX58
See in Reactome
R-HSA-5690827
(
R-HSA-5689896
)
R-HSA-5690827
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1
See in Reactome
R-HSA-5690856
(
R-HSA-5689896
)
R-HSA-5690856
Reaction Name: TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1
See in Reactome
R-HSA-5693055
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5693055
Reaction Name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes
See in Reactome
R-HSA-5693108
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5693108
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains
See in Reactome
R-HSA-5696627
(
R-HSA-5689880
)
R-HSA-5696627
Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
See in Reactome
R-HSA-75240
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-75240
Reaction Name: TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8
See in Reactome
R-HSA-83582
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-83582
Reaction Name: TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex.
See in Reactome
R-HSA-83656
(
R-HSA-75893
)
R-HSA-83656
Reaction Name: TNF:TNFR1 binds TRADD, TRAF2 and RIPK1
See in Reactome
R-HSA-9013889
(
R-HSA-9013957
)
R-HSA-9013889
Reaction Name: TLR3-induced ripoptosome assembly
See in Reactome
R-HSA-9013895
(
R-HSA-9013957
)
R-HSA-9013895
Reaction Name: Caspase-8 processing within TLR3 complex
See in Reactome
R-HSA-9013963
(
R-HSA-9013957
)
R-HSA-9013963
Reaction Name: RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis
See in Reactome
R-HSA-9014342
(
R-HSA-168927
)
R-HSA-9014342
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-9014343
(
R-HSA-168927
)
R-HSA-9014343
Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex
See in Reactome
R-HSA-933523
(
R-HSA-933543
)
R-HSA-933523
Reaction Name: Dimerzation of procaspase-8, procaspase-10
See in Reactome
R-HSA-933526
(
R-HSA-933543
)
R-HSA-933526
Reaction Name: Recruitment of caspase-8 and -10 to FADD complex
See in Reactome
R-HSA-933532
(
R-HSA-933543
)
R-HSA-933539
(
R-HSA-933543
)
R-HSA-937029
(
R-HSA-937041
)
R-HSA-937029
Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1
See in Reactome
R-HSA-9686336
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686338
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686338
Reaction Name: SARS-CoV-1 3a binds the lysosomal membrane
See in Reactome
R-HSA-9686345
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686345
Reaction Name: SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer
See in Reactome
R-HSA-9686920
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9686920
Reaction Name: PELI1 ubiquitinates RIPK3 at K363
See in Reactome
R-HSA-9686922
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9686922
Reaction Name: PELI1 binds activated RIPK1:RIPK3
See in Reactome
R-HSA-9687465
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9687625
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9687638
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9688456
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9688832
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9693978
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9693978
Reaction Name: Small molecule inhibitor binds RIPK1, RIPK3
See in Reactome
R-HSA-9697747
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-9697747
Reaction Name: Caspase-8 and FLIP(L) processing at TNFR signaling complex
See in Reactome
R-HSA-9697750
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-9697750
Reaction Name: RIPK1 is cleaved by CASP8:FLIP(L)
See in Reactome
R-HSA-9701055
(
R-HSA-3295583
)
R-HSA-9701055
Reaction Name: TRPA1 tetramer transports Ca2+ from extracellular region to cytosol
See in Reactome
R-HSA-9701141
(
R-HSA-3295583
)
R-HSA-9701141
Reaction Name: TRPV1 transports Ca2+ from extracellular region to cytosol
See in Reactome
|
MONDO:0030018 |
RIPK1 |
Q13546 |
2.7.11.1
|
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-3295583
R-HSA-168927
R-HSA-168927
Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment
See in Reactome
R-HSA-9686347
R-HSA-9686347
Reactome Name: Microbial modulation of RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-937041
R-HSA-937041
Reactome Name: IKK complex recruitment mediated by RIP1
See in Reactome
R-HSA-5213460
R-HSA-5213460
Reactome Name: RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5357905
R-HSA-5218900
R-HSA-140534
R-HSA-140534
Reactome Name: Caspase activation via Death Receptors in the presence of ligand
See in Reactome
R-HSA-2562578
R-HSA-2562578
Reactome Name: TRIF-mediated programmed cell death
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-1810476
R-HSA-1810476
Reactome Name: RIP-mediated NFkB activation via ZBP1
See in Reactome
R-HSA-69416
R-HSA-5675482
R-HSA-5675482
Reactome Name: Regulation of necroptotic cell death
See in Reactome
R-HSA-75893
R-HSA-3371378
R-HSA-5357786
R-HSA-5357786
Reactome Name: TNFR1-induced proapoptotic signaling
See in Reactome
R-HSA-9013957
R-HSA-9013957
Reactome Name: TLR3-mediated TICAM1-dependent programmed cell death
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-168256
R-HSA-382551
R-HSA-5357801
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168898
R-HSA-166166
R-HSA-1606322
R-HSA-1606322
Reactome Name: ZBP1(DAI) mediated induction of type I IFNs
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-983712
R-HSA-5357769
R-HSA-5357769
Reactome Name: Caspase activation via extrinsic apoptotic signalling pathway
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-5218859
R-HSA-73887
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
R-HSA-5688426
R-HSA-109581
R-HSA-2672351
R-HSA-162582
|
Immune System
Transport of small molecules
Programmed Cell Death
Metabolism of proteins
Signal Transduction
|
R-HSA-139952
(
R-HSA-140534
)
R-HSA-139952
Reaction Name: Caspase-8 processing in the DISC
See in Reactome
R-HSA-140978
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-140978
Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD
See in Reactome
R-HSA-141159
(
R-HSA-140534;
R-HSA-69416
)
R-HSA-141159
Reaction Name: TNF-mediated dimerization of procaspase-8
See in Reactome
R-HSA-168910
(
R-HSA-1810476
)
R-HSA-168910
Reaction Name: RIP1 facilitates IKK complex phosphorylation
See in Reactome
R-HSA-168915
(
R-HSA-937041
)
R-HSA-168915
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-168921
(
R-HSA-937041
)
R-HSA-168921
Reaction Name: TRIF:activated TLR3/TLR4 complex recruits RIP1
See in Reactome
R-HSA-168930
(
R-HSA-168927
)
R-HSA-168930
Reaction Name: Viral dsRNA:TLR3:TRIF complex recruits RIP1
See in Reactome
R-HSA-168934
(
R-HSA-933543
)
R-HSA-168934
Reaction Name: MAVS interacts with RIPK1 and FADD
See in Reactome
R-HSA-1810457
(
R-HSA-1810476
)
R-HSA-1810457
Reaction Name: ZBP1(DAI) recruits RIP1 and RIP3
See in Reactome
R-HSA-2562541
(
R-HSA-2562578
)
R-HSA-2562541
Reaction Name: TLR4-induced ripoptosome assembly
See in Reactome
R-HSA-2562564
(
R-HSA-140534;
R-HSA-2562578
)
R-HSA-2562564
Reaction Name: Caspase-8 processing within TLR4 complex
See in Reactome
R-HSA-2569057
(
R-HSA-2562578
)
R-HSA-2569057
Reaction Name: RIP3 binds TRIF to mediate necroptosis
See in Reactome
R-HSA-3295579
(
R-HSA-3295583
)
R-HSA-3295579
Reaction Name: TRPs transport extracellular Ca2+ to cytosol
See in Reactome
R-HSA-3371360
(
R-HSA-140534;
R-HSA-3371378;
R-HSA-5357905;
R-HSA-75893
)
R-HSA-3371360
Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling
See in Reactome
R-HSA-3465429
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5675482
)
R-HSA-3465429
Reaction Name: FLIP(S) and procaspase-8 form heterodimer
See in Reactome
R-HSA-3465448
(
R-HSA-140534;
R-HSA-3371378
)
R-HSA-3465448
Reaction Name: Caspase-8 and FLIP(L) processing at DISC
See in Reactome
R-HSA-5213462
(
R-HSA-5213460
)
R-HSA-5213464
(
R-HSA-5213460
)
R-HSA-5213466
(
R-HSA-5213460
)
R-HSA-5218891
(
R-HSA-5213460
)
R-HSA-5218891
Reaction Name: RIPK1:RIPK3 oligomer binds MLKL
See in Reactome
R-HSA-5218905
(
R-HSA-5213460
)
R-HSA-5218905
Reaction Name: RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils
See in Reactome
R-HSA-5218906
(
R-HSA-5213460
)
R-HSA-5357757
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357757
Reaction Name: BIRC(cIAP1/2) ubiquitinates RIPK1
See in Reactome
R-HSA-5357776
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357780
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357780
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2)
See in Reactome
R-HSA-5357828
(
R-HSA-5213460;
R-HSA-5357905;
R-HSA-5675482;
R-HSA-75893
)
R-HSA-5357845
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357860
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5357904
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357904
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
See in Reactome
R-HSA-5357927
(
R-HSA-5213460
)
R-HSA-5357928
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357928
Reaction Name: CLIP3 and CYLD bind TNF signaling complex
See in Reactome
R-HSA-5620975
(
R-HSA-5213460
)
R-HSA-5634221
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5634221
Reaction Name: TRAF1 binds TRAF2 within TNFR1 signaling complex
See in Reactome
R-HSA-5675456
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5675482
)
R-HSA-5675456
Reaction Name: FLIP(L) and procaspase-8 form heterodimer
See in Reactome
R-HSA-5690159
(
R-HSA-5689880
)
R-HSA-5690159
Reaction Name: USP21 deubiquitinates RIPK1,DDX58
See in Reactome
R-HSA-5690827
(
R-HSA-5689896
)
R-HSA-5690827
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1
See in Reactome
R-HSA-5690856
(
R-HSA-5689896
)
R-HSA-5690856
Reaction Name: TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1
See in Reactome
R-HSA-5693055
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5693055
Reaction Name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes
See in Reactome
R-HSA-5693108
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5693108
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains
See in Reactome
R-HSA-5696627
(
R-HSA-5689880
)
R-HSA-5696627
Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
See in Reactome
R-HSA-75240
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-75240
Reaction Name: TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8
See in Reactome
R-HSA-83582
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-83582
Reaction Name: TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex.
See in Reactome
R-HSA-83656
(
R-HSA-75893
)
R-HSA-83656
Reaction Name: TNF:TNFR1 binds TRADD, TRAF2 and RIPK1
See in Reactome
R-HSA-9013889
(
R-HSA-9013957
)
R-HSA-9013889
Reaction Name: TLR3-induced ripoptosome assembly
See in Reactome
R-HSA-9013895
(
R-HSA-9013957
)
R-HSA-9013895
Reaction Name: Caspase-8 processing within TLR3 complex
See in Reactome
R-HSA-9013963
(
R-HSA-9013957
)
R-HSA-9013963
Reaction Name: RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis
See in Reactome
R-HSA-9014342
(
R-HSA-168927
)
R-HSA-9014342
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-9014343
(
R-HSA-168927
)
R-HSA-9014343
Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex
See in Reactome
R-HSA-933523
(
R-HSA-933543
)
R-HSA-933523
Reaction Name: Dimerzation of procaspase-8, procaspase-10
See in Reactome
R-HSA-933526
(
R-HSA-933543
)
R-HSA-933526
Reaction Name: Recruitment of caspase-8 and -10 to FADD complex
See in Reactome
R-HSA-933532
(
R-HSA-933543
)
R-HSA-933539
(
R-HSA-933543
)
R-HSA-937029
(
R-HSA-937041
)
R-HSA-937029
Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1
See in Reactome
R-HSA-9686336
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686338
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686338
Reaction Name: SARS-CoV-1 3a binds the lysosomal membrane
See in Reactome
R-HSA-9686345
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686345
Reaction Name: SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer
See in Reactome
R-HSA-9686920
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9686920
Reaction Name: PELI1 ubiquitinates RIPK3 at K363
See in Reactome
R-HSA-9686922
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9686922
Reaction Name: PELI1 binds activated RIPK1:RIPK3
See in Reactome
R-HSA-9687465
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9687625
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9687638
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9688456
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9688832
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9693978
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9693978
Reaction Name: Small molecule inhibitor binds RIPK1, RIPK3
See in Reactome
R-HSA-9697747
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-9697747
Reaction Name: Caspase-8 and FLIP(L) processing at TNFR signaling complex
See in Reactome
R-HSA-9697750
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-9697750
Reaction Name: RIPK1 is cleaved by CASP8:FLIP(L)
See in Reactome
R-HSA-9701055
(
R-HSA-3295583
)
R-HSA-9701055
Reaction Name: TRPA1 tetramer transports Ca2+ from extracellular region to cytosol
See in Reactome
R-HSA-9701141
(
R-HSA-3295583
)
R-HSA-9701141
Reaction Name: TRPV1 transports Ca2+ from extracellular region to cytosol
See in Reactome
|
MONDO:0030872 |
CYLD |
Q9NQC7 |
3.4.19.12
|
R-HSA-5357786
R-HSA-5357786
Reactome Name: TNFR1-induced proapoptotic signaling
See in Reactome
R-HSA-168638
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-936440
R-HSA-936440
Reactome Name: Negative regulators of DDX58/IFIH1 signaling
See in Reactome
R-HSA-5357905
|
R-HSA-5688426
R-HSA-168256
R-HSA-392499
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-73887
R-HSA-75893
R-HSA-168249
R-HSA-162582
|
Immune System
Metabolism of proteins
Signal Transduction
|
R-HSA-140978
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-140978
Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD
See in Reactome
R-HSA-5357776
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357831
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357845
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357860
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5357928
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357928
Reaction Name: CLIP3 and CYLD bind TNF signaling complex
See in Reactome
R-HSA-5696627
(
R-HSA-5689880
)
R-HSA-5696627
Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
See in Reactome
R-HSA-741411
(
R-HSA-168638
)
R-HSA-936390
(
R-HSA-5689880;
R-HSA-936440
)
R-HSA-936390
Reaction Name: CYLD mediated deubiquitination of DDX58 (RIG-I)
See in Reactome
|
MONDO:0032599 |
IKBKB |
O14920 |
2.7.11.10
2.7.11.1
|
R-HSA-5684264
R-HSA-5684264
Reactome Name: MAP3K8 (TPL2)-dependent MAPK1/3 activation
See in Reactome
R-HSA-9020702
R-HSA-937039
R-HSA-202424
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-933542
R-HSA-933542
Reactome Name: TRAF6 mediated NF-kB activation
See in Reactome
R-HSA-937041
R-HSA-937041
Reactome Name: IKK complex recruitment mediated by RIP1
See in Reactome
R-HSA-168638
R-HSA-1236974
R-HSA-5357905
R-HSA-975144
R-HSA-975144
Reactome Name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-445989
R-HSA-445989
Reactome Name: TAK1-dependent IKK and NF-kappa-B activation
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-1810476
R-HSA-1810476
Reactome Name: RIP-mediated NFkB activation via ZBP1
See in Reactome
R-HSA-209543
R-HSA-209543
Reactome Name: p75NTR recruits signalling complexes
See in Reactome
R-HSA-209560
R-HSA-209560
Reactome Name: NF-kB is activated and signals survival
See in Reactome
R-HSA-5607764
R-HSA-1169091
R-HSA-1169091
Reactome Name: Activation of NF-kappaB in B cells
See in Reactome
R-HSA-168927
R-HSA-168927
Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment
See in Reactome
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-449147
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-1280218
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-168898
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-73887
R-HSA-1606322
R-HSA-1606322
Reactome Name: ZBP1(DAI) mediated induction of type I IFNs
See in Reactome
R-HSA-202403
R-HSA-446652
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-193639
R-HSA-166166
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
R-HSA-75893
R-HSA-450294
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-448424
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
|