DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-5357786)

Number of enzymes:	4
Number of disease:	9
Number of reactomes:	29
Number of reactions:	96

Search results (Reactome ID: R-HSA-5357786)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007565	CYLD	Q9NQC7	3.4.19.12	R-HSA-5357786 R-HSA-5357786 Reactome Name: TNFR1-induced proapoptotic signaling See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-5357956 R-HSA-5357956 Reactome Name: TNFR1-induced NFkappaB signaling pathway See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome	R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism of proteins Signal Transduction	R-HSA-140978 ( R-HSA-5357786 ) R-HSA-140978 Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD See in Reactome R-HSA-5357776 ( R-HSA-5357956 ) R-HSA-5357776 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG See in Reactome R-HSA-5357831 ( R-HSA-5357905 ) R-HSA-5357831 Reaction Name: CYLD is phosphorylated by IKK See in Reactome R-HSA-5357845 ( R-HSA-5357905 ) R-HSA-5357845 Reaction Name: RIPK1 is deubiquitinated See in Reactome R-HSA-5357860 ( R-HSA-5357956 ) R-HSA-5357860 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex See in Reactome R-HSA-5357928 ( R-HSA-5357905 ) R-HSA-5357928 Reaction Name: CLIP3 and CYLD bind TNF signaling complex See in Reactome R-HSA-5696627 ( R-HSA-5689880 ) R-HSA-5696627 Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG See in Reactome R-HSA-741411 ( R-HSA-168638 ) R-HSA-741411 Reaction Name: CYLD deubiquitinates NEMO See in Reactome R-HSA-936390 ( R-HSA-5689880; R-HSA-936440 ) R-HSA-936390 Reaction Name: CYLD mediated deubiquitination of DDX58 (RIG-I) See in Reactome
MONDO:0011804	CASP8	Q14790	3.4.22.61	R-HSA-75153 R-HSA-75153 Reactome Name: Apoptotic execution phase See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-75158 R-HSA-75158 Reactome Name: TRAIL signaling See in Reactome R-HSA-75108 R-HSA-75108 Reactome Name: Activation, myristolyation of BID and translocation to mitochondria See in Reactome R-HSA-9686347 R-HSA-9686347 Reactome Name: Microbial modulation of RIPK1-mediated regulated necrosis See in Reactome R-HSA-264870 R-HSA-264870 Reactome Name: Caspase-mediated cleavage of cytoskeletal proteins See in Reactome R-HSA-111465 R-HSA-111465 Reactome Name: Apoptotic cleavage of cellular proteins See in Reactome R-HSA-5213460 R-HSA-5213460 Reactome Name: RIPK1-mediated regulated necrosis See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-5660668 R-HSA-5660668 Reactome Name: CLEC7A/inflammasome pathway See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome R-HSA-5218900 R-HSA-5218900 Reactome Name: CASP8 activity is inhibited See in Reactome R-HSA-140534 R-HSA-140534 Reactome Name: Caspase activation via Death Receptors in the presence of ligand See in Reactome R-HSA-2562578 R-HSA-2562578 Reactome Name: TRIF-mediated programmed cell death See in Reactome R-HSA-75157 R-HSA-75157 Reactome Name: FasL/ CD95L signaling See in Reactome R-HSA-69416 R-HSA-69416 Reactome Name: Dimerization of procaspase-8 See in Reactome R-HSA-5675482 R-HSA-5675482 Reactome Name: Regulation of necroptotic cell death See in Reactome R-HSA-3371378 R-HSA-3371378 Reactome Name: Regulation by c-FLIP See in Reactome R-HSA-5357786 R-HSA-5357786 Reactome Name: TNFR1-induced proapoptotic signaling See in Reactome R-HSA-9013957 R-HSA-9013957 Reactome Name: TLR3-mediated TICAM1-dependent programmed cell death See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-5357769 R-HSA-5357769 Reactome Name: Caspase activation via extrinsic apoptotic signalling pathway See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-5218859 R-HSA-5218859 Reactome Name: Regulated Necrosis See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Signal Transduction	R-HSA-139898 ( R-HSA-75108 ) R-HSA-139898 Reaction Name: Caspase-8 activates BID by cleavage See in Reactome R-HSA-139952 ( R-HSA-140534 ) R-HSA-139952 Reaction Name: Caspase-8 processing in the DISC See in Reactome R-HSA-141156 ( R-HSA-140534; R-HSA-69416 ) R-HSA-141156 Reaction Name: TRAIL-mediated dimerization of procaspase-8 See in Reactome R-HSA-141159 ( R-HSA-140534; R-HSA-69416 ) R-HSA-141159 Reaction Name: TNF-mediated dimerization of procaspase-8 See in Reactome R-HSA-201637 ( R-HSA-111465; R-HSA-264870; R-HSA-75153 ) R-HSA-201637 Reaction Name: Caspase-mediated cleavage of plectin-1 See in Reactome R-HSA-2562541 ( R-HSA-2562578 ) R-HSA-2562541 Reaction Name: TLR4-induced ripoptosome assembly See in Reactome R-HSA-2562564 ( R-HSA-140534; R-HSA-2562578 ) R-HSA-2562564 Reaction Name: Caspase-8 processing within TLR4 complex See in Reactome R-HSA-2672196 ( R-HSA-5213460; R-HSA-5218900; R-HSA-5357905; R-HSA-5675482; R-HSA-9686347 ) R-HSA-2672196 Reaction Name: Viral serpin blocks caspase-8 activity See in Reactome R-HSA-3371359 ( R-HSA-140534; R-HSA-3371378 ) R-HSA-3371359 Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling See in Reactome R-HSA-3371360 ( R-HSA-140534; R-HSA-3371378; R-HSA-5357905 ) R-HSA-3371360 Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling See in Reactome R-HSA-3465429 ( R-HSA-5213460; R-HSA-5218900; R-HSA-5675482 ) R-HSA-3465429 Reaction Name: FLIP(S) and procaspase-8 form heterodimer See in Reactome R-HSA-3465448 ( R-HSA-140534; R-HSA-3371378 ) R-HSA-3465448 Reaction Name: Caspase-8 and FLIP(L) processing at DISC See in Reactome R-HSA-3465459 ( R-HSA-140534; R-HSA-3371378 ) R-HSA-3465459 Reaction Name: FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling See in Reactome R-HSA-350319 ( R-HSA-111465; R-HSA-264870; R-HSA-75153 ) R-HSA-350319 Reaction Name: Caspase mediated cleavage of vimentin at IDVD (259) See in Reactome R-HSA-351863 ( R-HSA-75153 ) R-HSA-351863 Reaction Name: Translocation of active caspase-8 to the mitochondrial membrane See in Reactome R-HSA-351894 ( R-HSA-111465; R-HSA-75153 ) R-HSA-351894 Reaction Name: Caspase mediated cleavage of BAP31 See in Reactome R-HSA-5213462 ( R-HSA-5213460 ) R-HSA-5213462 Reaction Name: RIPK3 binds RIPK1 See in Reactome R-HSA-5357828 ( R-HSA-5213460; R-HSA-5357905; R-HSA-5675482 ) R-HSA-5357828 Reaction Name: RIPK1 is cleaved by CASP8 See in Reactome R-HSA-5634228 ( R-HSA-5357905 ) R-HSA-5634228 Reaction Name: TRAF1 is cleaved by caspases See in Reactome R-HSA-5660662 ( R-HSA-5660668 ) R-HSA-5660662 Reaction Name: ASC binds Caspase-8 complex See in Reactome R-HSA-5660663 ( R-HSA-5660668 ) R-HSA-5660663 Reaction Name: Caspase-8 cleaves IL1B precursor See in Reactome R-HSA-5660665 ( R-HSA-5660668 ) R-HSA-5660665 Reaction Name: Caspase-8 binds MALT See in Reactome R-HSA-5675456 ( R-HSA-5213460; R-HSA-5218900; R-HSA-5675482 ) R-HSA-5675456 Reaction Name: FLIP(L) and procaspase-8 form heterodimer See in Reactome R-HSA-5692550 ( R-HSA-5357905 ) R-HSA-5692550 Reaction Name: Viral inhibitor of caspase-8 activation (UL36) binds caspase-8 See in Reactome R-HSA-622420 ( R-HSA-168638 ) R-HSA-622420 Reaction Name: NOD1 induced apoptosis is mediated by RIP2 and CARD8 See in Reactome R-HSA-73945 ( R-HSA-140534; R-HSA-69416 ) R-HSA-73945 Reaction Name: FAS-mediated dimerization of procaspase-8 See in Reactome R-HSA-75146 ( R-HSA-75158 ) R-HSA-75146 Reaction Name: TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 See in Reactome R-HSA-75240 ( R-HSA-5357786 ) R-HSA-75240 Reaction Name: TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8 See in Reactome R-HSA-83586 ( R-HSA-75157 ) R-HSA-83586 Reaction Name: FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 See in Reactome R-HSA-9013889 ( R-HSA-9013957 ) R-HSA-9013889 Reaction Name: TLR3-induced ripoptosome assembly See in Reactome R-HSA-9013895 ( R-HSA-9013957 ) R-HSA-9013895 Reaction Name: Caspase-8 processing within TLR3 complex See in Reactome R-HSA-933523 ( R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933526 ( R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933532 ( R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933539 ( R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-9686930 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9686930 Reaction Name: RIPK3 is cleaved by CASP8 See in Reactome R-HSA-9687458 ( R-HSA-5213460; R-HSA-9686347 ) R-HSA-9687458 Reaction Name: HSV1 RIR1 binds CASP8 See in Reactome R-HSA-9697747 ( R-HSA-5357905 ) R-HSA-9697747 Reaction Name: Caspase-8 and FLIP(L) processing at TNFR signaling complex See in Reactome R-HSA-9697750 ( R-HSA-5357905 ) R-HSA-9697750 Reaction Name: RIPK1 is cleaved by CASP8:FLIP(L) See in Reactome
MONDO:0014761	TNFAIP3	P21580	2.3.2.- 3.4.19.12	R-HSA-5357786 R-HSA-5357786 Reactome Name: TNFR1-induced proapoptotic signaling See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome R-HSA-5357956 R-HSA-5357956 Reactome Name: TNFR1-induced NFkappaB signaling pathway See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome	R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism of proteins Signal Transduction	R-HSA-140978 ( R-HSA-5357786 ) R-HSA-140978 Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD See in Reactome R-HSA-5357776 ( R-HSA-5357956 ) R-HSA-5357776 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG See in Reactome R-HSA-5357845 ( R-HSA-5357905 ) R-HSA-5357845 Reaction Name: RIPK1 is deubiquitinated See in Reactome R-HSA-5357860 ( R-HSA-5357956 ) R-HSA-5357860 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex See in Reactome R-HSA-5690827 ( R-HSA-5689896 ) R-HSA-5690827 Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 See in Reactome R-HSA-5690845 ( R-HSA-5689896 ) R-HSA-5690845 Reaction Name: TNIPs bind TNFAIP3 (A20) See in Reactome R-HSA-5690856 ( R-HSA-5689896 ) R-HSA-5690856 Reaction Name: TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 See in Reactome R-HSA-5690870 ( R-HSA-5689896 ) R-HSA-5690870 Reaction Name: OTUD7B,TNFAIP3 deubiquitinate TRAF6 See in Reactome R-HSA-5693055 ( R-HSA-5357905 ) R-HSA-5693055 Reaction Name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes See in Reactome R-HSA-5693108 ( R-HSA-5357905 ) R-HSA-5693108 Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains See in Reactome R-HSA-688136 ( R-HSA-168638; R-HSA-5689896 ) R-HSA-688136 Reaction Name: TNFAIP3 (A20) deubiquitinates RIP2 See in Reactome R-HSA-8869506 ( R-HSA-5689896 ) R-HSA-8869506 Reaction Name: TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 See in Reactome R-HSA-937337 ( R-HSA-936440 ) R-HSA-937337 Reaction Name: TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination See in Reactome
MONDO:0016216	CASP8	Q14790	3.4.22.61	R-HSA-75153 R-HSA-75153 Reactome Name: Apoptotic execution phase See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-75158 R-HSA-75158 Reactome Name: TRAIL signaling See in Reactome R-HSA-75108 R-HSA-75108 Reactome Name: Activation, myristolyation of BID and translocation to mitochondria See in Reactome R-HSA-9686347 R-HSA-9686347 Reactome Name: Microbial modulation of RIPK1-mediated regulated necrosis See in Reactome R-HSA-264870 R-HSA-264870 Reactome Name: Caspase-mediated cleavage of cytoskeletal proteins See in Reactome R-HSA-111465 R-HSA-111465 Reactome Name: Apoptotic cleavage of cellular proteins See in Reactome R-HSA-5213460 R-HSA-5213460 Reactome Name: RIPK1-mediated regulated necrosis See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-5660668 R-HSA-5660668 Reactome Name: CLEC7A/inflammasome pathway See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome R-HSA-5218900 R-HSA-5218900 Reactome Name: CASP8 activity is inhibited See in Reactome R-HSA-140534 R-HSA-140534 Reactome Name: Caspase activation via Death Receptors in the presence of ligand See in Reactome R-HSA-2562578 R-HSA-2562578 Reactome Name: TRIF-mediated programmed cell death See in Reactome R-HSA-75157 R-HSA-75157 Reactome Name: FasL/ CD95L signaling See in Reactome R-HSA-69416 R-HSA-69416 Reactome Name: Dimerization of procaspase-8 See in Reactome R-HSA-5675482 R-HSA-5675482 Reactome Name: Regulation of necroptotic cell death See in Reactome R-HSA-3371378 R-HSA-3371378 Reactome Name: Regulation by c-FLIP See in Reactome R-HSA-5357786 R-HSA-5357786 Reactome Name: TNFR1-induced proapoptotic signaling See in Reactome R-HSA-9013957 R-HSA-9013957 Reactome Name: TLR3-mediated TICAM1-dependent programmed cell death See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-5357769 R-HSA-5357769 Reactome Name: Caspase activation via extrinsic apoptotic signalling pathway See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-5218859 R-HSA-5218859 Reactome Name: Regulated Necrosis See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Signal Transduction	R-HSA-139898 ( R-HSA-75108 ) R-HSA-139898 Reaction Name: Caspase-8 activates BID by cleavage See in Reactome R-HSA-139952 ( R-HSA-140534 ) R-HSA-139952 Reaction Name: Caspase-8 processing in the DISC See in Reactome R-HSA-141156 ( R-HSA-140534; R-HSA-69416 ) R-HSA-141156 Reaction Name: TRAIL-mediated dimerization of procaspase-8 See in Reactome R-HSA-141159 ( R-HSA-140534; R-HSA-69416 ) R-HSA-141159 Reaction Name: TNF-mediated dimerization of procaspase-8 See in Reactome R-HSA-201637 ( R-HSA-111465; R-HSA-264870; R-HSA-75153 ) R-HSA-201637 Reaction Name: Caspase-mediated cleavage of plectin-1 See in Reactome R-HSA-2562541 ( R-HSA-2562578 ) R-HSA-2562541 Reaction Name: TLR4-induced ripoptosome assembly See in Reactome R-HSA-2562564 ( R-HSA-140534; R-HSA-2562578 ) R-HSA-2562564 Reaction Name: Caspase-8 processing within TLR4 complex See in Reactome R-HSA-2672196 ( R-HSA-5213460; R-HSA-5218900; R-HSA-5357905; R-HSA-5675482; R-HSA-9686347 ) R-HSA-2672196 Reaction Name: Viral serpin blocks caspase-8 activity See in Reactome R-HSA-3371359 ( R-HSA-140534; R-HSA-3371378 ) R-HSA-3371359 Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling See in Reactome R-HSA-3371360 ( R-HSA-140534; R-HSA-3371378; R-HSA-5357905 ) R-HSA-3371360 Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling See in Reactome R-HSA-3465429 ( R-HSA-5213460; R-HSA-5218900; R-HSA-5675482 ) R-HSA-3465429 Reaction Name: FLIP(S) and procaspase-8 form heterodimer See in Reactome R-HSA-3465448 ( R-HSA-140534; R-HSA-3371378 ) R-HSA-3465448 Reaction Name: Caspase-8 and FLIP(L) processing at DISC See in Reactome R-HSA-3465459 ( R-HSA-140534; R-HSA-3371378 ) R-HSA-3465459 Reaction Name: FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling See in Reactome R-HSA-350319 ( R-HSA-111465; R-HSA-264870; R-HSA-75153 ) R-HSA-350319 Reaction Name: Caspase mediated cleavage of vimentin at IDVD (259) See in Reactome R-HSA-351863 ( R-HSA-75153 ) R-HSA-351863 Reaction Name: Translocation of active caspase-8 to the mitochondrial membrane See in Reactome R-HSA-351894 ( R-HSA-111465; R-HSA-75153 ) R-HSA-351894 Reaction Name: Caspase mediated cleavage of BAP31 See in Reactome R-HSA-5213462 ( R-HSA-5213460 ) R-HSA-5213462 Reaction Name: RIPK3 binds RIPK1 See in Reactome R-HSA-5357828 ( R-HSA-5213460; R-HSA-5357905; R-HSA-5675482 ) R-HSA-5357828 Reaction Name: RIPK1 is cleaved by CASP8 See in Reactome R-HSA-5634228 ( R-HSA-5357905 ) R-HSA-5634228 Reaction Name: TRAF1 is cleaved by caspases See in Reactome R-HSA-5660662 ( R-HSA-5660668 ) R-HSA-5660662 Reaction Name: ASC binds Caspase-8 complex See in Reactome R-HSA-5660663 ( R-HSA-5660668 ) R-HSA-5660663 Reaction Name: Caspase-8 cleaves IL1B precursor See in Reactome R-HSA-5660665 ( R-HSA-5660668 ) R-HSA-5660665 Reaction Name: Caspase-8 binds MALT See in Reactome R-HSA-5675456 ( R-HSA-5213460; R-HSA-5218900; R-HSA-5675482 ) R-HSA-5675456 Reaction Name: FLIP(L) and procaspase-8 form heterodimer See in Reactome R-HSA-5692550 ( R-HSA-5357905 ) R-HSA-5692550 Reaction Name: Viral inhibitor of caspase-8 activation (UL36) binds caspase-8 See in Reactome R-HSA-622420 ( R-HSA-168638 ) R-HSA-622420 Reaction Name: NOD1 induced apoptosis is mediated by RIP2 and CARD8 See in Reactome R-HSA-73945 ( R-HSA-140534; R-HSA-69416 ) R-HSA-73945 Reaction Name: FAS-mediated dimerization of procaspase-8 See in Reactome R-HSA-75146 ( R-HSA-75158 ) R-HSA-75146 Reaction Name: TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 See in Reactome R-HSA-75240 ( R-HSA-5357786 ) R-HSA-75240 Reaction Name: TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8 See in Reactome R-HSA-83586 ( R-HSA-75157 ) R-HSA-83586 Reaction Name: FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 See in Reactome R-HSA-9013889 ( R-HSA-9013957 ) R-HSA-9013889 Reaction Name: TLR3-induced ripoptosome assembly See in Reactome R-HSA-9013895 ( R-HSA-9013957 ) R-HSA-9013895 Reaction Name: Caspase-8 processing within TLR3 complex See in Reactome R-HSA-933523 ( R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933526 ( R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933532 ( R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933539 ( R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-9686930 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9686930 Reaction Name: RIPK3 is cleaved by CASP8 See in Reactome R-HSA-9687458 ( R-HSA-5213460; R-HSA-9686347 ) R-HSA-9687458 Reaction Name: HSV1 RIR1 binds CASP8 See in Reactome R-HSA-9697747 ( R-HSA-5357905 ) R-HSA-9697747 Reaction Name: Caspase-8 and FLIP(L) processing at TNFR signaling complex See in Reactome R-HSA-9697750 ( R-HSA-5357905 ) R-HSA-9697750 Reaction Name: RIPK1 is cleaved by CASP8:FLIP(L) See in Reactome
MONDO:0020849	RIPK1	Q13546	2.7.11.1	R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-3295583 R-HSA-3295583 Reactome Name: TRP channels See in Reactome R-HSA-168927 R-HSA-168927 Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment See in Reactome R-HSA-9686347 R-HSA-9686347 Reactome Name: Microbial modulation of RIPK1-mediated regulated necrosis See in Reactome R-HSA-937041 R-HSA-937041 Reactome Name: IKK complex recruitment mediated by RIP1 See in Reactome R-HSA-5213460 R-HSA-5213460 Reactome Name: RIPK1-mediated regulated necrosis See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome R-HSA-5218900 R-HSA-5218900 Reactome Name: CASP8 activity is inhibited See in Reactome R-HSA-140534 R-HSA-140534 Reactome Name: Caspase activation via Death Receptors in the presence of ligand See in Reactome R-HSA-2562578 R-HSA-2562578 Reactome Name: TRIF-mediated programmed cell death See in Reactome R-HSA-5357956 R-HSA-5357956 Reactome Name: TNFR1-induced NFkappaB signaling pathway See in Reactome R-HSA-1810476 R-HSA-1810476 Reactome Name: RIP-mediated NFkB activation via ZBP1 See in Reactome R-HSA-69416 R-HSA-69416 Reactome Name: Dimerization of procaspase-8 See in Reactome R-HSA-5675482 R-HSA-5675482 Reactome Name: Regulation of necroptotic cell death See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-3371378 R-HSA-3371378 Reactome Name: Regulation by c-FLIP See in Reactome R-HSA-5357786 R-HSA-5357786 Reactome Name: TNFR1-induced proapoptotic signaling See in Reactome R-HSA-9013957 R-HSA-9013957 Reactome Name: TLR3-mediated TICAM1-dependent programmed cell death See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-1606322 R-HSA-1606322 Reactome Name: ZBP1(DAI) mediated induction of type I IFNs See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-983712 R-HSA-983712 Reactome Name: Ion channel transport See in Reactome R-HSA-5357769 R-HSA-5357769 Reactome Name: Caspase activation via extrinsic apoptotic signalling pathway See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-5218859 R-HSA-5218859 Reactome Name: Regulated Necrosis See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-2672351 R-HSA-2672351 Reactome Name: Stimuli-sensing channels See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Transport of small molecules Programmed Cell Death Metabolism of proteins Signal Transduction	R-HSA-139952 ( R-HSA-140534 ) R-HSA-139952 Reaction Name: Caspase-8 processing in the DISC See in Reactome R-HSA-140978 ( R-HSA-5357786; R-HSA-75893 ) R-HSA-140978 Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD See in Reactome R-HSA-141159 ( R-HSA-140534; R-HSA-69416 ) R-HSA-141159 Reaction Name: TNF-mediated dimerization of procaspase-8 See in Reactome R-HSA-168910 ( R-HSA-1810476 ) R-HSA-168910 Reaction Name: RIP1 facilitates IKK complex phosphorylation See in Reactome R-HSA-168915 ( R-HSA-937041 ) R-HSA-168915 Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex See in Reactome R-HSA-168921 ( R-HSA-937041 ) R-HSA-168921 Reaction Name: TRIF:activated TLR3/TLR4 complex recruits RIP1 See in Reactome R-HSA-168930 ( R-HSA-168927 ) R-HSA-168930 Reaction Name: Viral dsRNA:TLR3:TRIF complex recruits RIP1 See in Reactome R-HSA-168934 ( R-HSA-933543 ) R-HSA-168934 Reaction Name: MAVS interacts with RIPK1 and FADD See in Reactome R-HSA-1810457 ( R-HSA-1810476 ) R-HSA-1810457 Reaction Name: ZBP1(DAI) recruits RIP1 and RIP3 See in Reactome R-HSA-2562541 ( R-HSA-2562578 ) R-HSA-2562541 Reaction Name: TLR4-induced ripoptosome assembly See in Reactome R-HSA-2562564 ( R-HSA-140534; R-HSA-2562578 ) R-HSA-2562564 Reaction Name: Caspase-8 processing within TLR4 complex See in Reactome R-HSA-2569057 ( R-HSA-2562578 ) R-HSA-2569057 Reaction Name: RIP3 binds TRIF to mediate necroptosis See in Reactome R-HSA-3295579 ( R-HSA-3295583 ) R-HSA-3295579 Reaction Name: TRPs transport extracellular Ca2+ to cytosol See in Reactome R-HSA-3371360 ( R-HSA-140534; R-HSA-3371378; R-HSA-5357905; R-HSA-75893 ) R-HSA-3371360 Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling See in Reactome R-HSA-3465429 ( R-HSA-5213460; R-HSA-5218900; R-HSA-5675482 ) R-HSA-3465429 Reaction Name: FLIP(S) and procaspase-8 form heterodimer See in Reactome R-HSA-3465448 ( R-HSA-140534; R-HSA-3371378 ) R-HSA-3465448 Reaction Name: Caspase-8 and FLIP(L) processing at DISC See in Reactome R-HSA-5213462 ( R-HSA-5213460 ) R-HSA-5213462 Reaction Name: RIPK3 binds RIPK1 See in Reactome R-HSA-5213464 ( R-HSA-5213460 ) R-HSA-5213464 Reaction Name: RIPK1 is phosphorylated See in Reactome R-HSA-5213466 ( R-HSA-5213460 ) R-HSA-5213466 Reaction Name: RIPK3 is phosphorylated See in Reactome R-HSA-5218891 ( R-HSA-5213460 ) R-HSA-5218891 Reaction Name: RIPK1:RIPK3 oligomer binds MLKL See in Reactome R-HSA-5218905 ( R-HSA-5213460 ) R-HSA-5218905 Reaction Name: RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils See in Reactome R-HSA-5218906 ( R-HSA-5213460 ) R-HSA-5218906 Reaction Name: RIPK3 phosphorylates MLKL See in Reactome R-HSA-5357757 ( R-HSA-5357956; R-HSA-75893 ) R-HSA-5357757 Reaction Name: BIRC(cIAP1/2) ubiquitinates RIPK1 See in Reactome R-HSA-5357776 ( R-HSA-5357956; R-HSA-75893 ) R-HSA-5357776 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG See in Reactome R-HSA-5357780 ( R-HSA-5357956; R-HSA-75893 ) R-HSA-5357780 Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) See in Reactome R-HSA-5357828 ( R-HSA-5213460; R-HSA-5357905; R-HSA-5675482; R-HSA-75893 ) R-HSA-5357828 Reaction Name: RIPK1 is cleaved by CASP8 See in Reactome R-HSA-5357845 ( R-HSA-5357905; R-HSA-75893 ) R-HSA-5357845 Reaction Name: RIPK1 is deubiquitinated See in Reactome R-HSA-5357860 ( R-HSA-5357956; R-HSA-75893 ) R-HSA-5357860 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex See in Reactome R-HSA-5357904 ( R-HSA-5357956; R-HSA-75893 ) R-HSA-5357904 Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC See in Reactome R-HSA-5357927 ( R-HSA-5213460 ) R-HSA-5357927 Reaction Name: MLKL oligomerizes See in Reactome R-HSA-5357928 ( R-HSA-5357905; R-HSA-75893 ) R-HSA-5357928 Reaction Name: CLIP3 and CYLD bind TNF signaling complex See in Reactome R-HSA-5620975 ( R-HSA-5213460 ) R-HSA-5620975 Reaction Name: MLKL binds PIPs See in Reactome R-HSA-5634221 ( R-HSA-5357905; R-HSA-75893 ) R-HSA-5634221 Reaction Name: TRAF1 binds TRAF2 within TNFR1 signaling complex See in Reactome R-HSA-5675456 ( R-HSA-5213460; R-HSA-5218900; R-HSA-5675482 ) R-HSA-5675456 Reaction Name: FLIP(L) and procaspase-8 form heterodimer See in Reactome R-HSA-5690159 ( R-HSA-5689880 ) R-HSA-5690159 Reaction Name: USP21 deubiquitinates RIPK1,DDX58 See in Reactome R-HSA-5690827 ( R-HSA-5689896 ) R-HSA-5690827 Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 See in Reactome R-HSA-5690856 ( R-HSA-5689896 ) R-HSA-5690856 Reaction Name: TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 See in Reactome R-HSA-5693055 ( R-HSA-5357905; R-HSA-75893 ) R-HSA-5693055 Reaction Name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes See in Reactome R-HSA-5693108 ( R-HSA-5357905; R-HSA-75893 ) R-HSA-5693108 Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains See in Reactome R-HSA-5696627 ( R-HSA-5689880 ) R-HSA-5696627 Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG See in Reactome R-HSA-75240 ( R-HSA-5357786; R-HSA-75893 ) R-HSA-75240 Reaction Name: TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8 See in Reactome R-HSA-83582 ( R-HSA-5357786; R-HSA-75893 ) R-HSA-83582 Reaction Name: TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex. See in Reactome R-HSA-83656 ( R-HSA-75893 ) R-HSA-83656 Reaction Name: TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 See in Reactome R-HSA-9013889 ( R-HSA-9013957 ) R-HSA-9013889 Reaction Name: TLR3-induced ripoptosome assembly See in Reactome R-HSA-9013895 ( R-HSA-9013957 ) R-HSA-9013895 Reaction Name: Caspase-8 processing within TLR3 complex See in Reactome R-HSA-9013963 ( R-HSA-9013957 ) R-HSA-9013963 Reaction Name: RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis See in Reactome R-HSA-9014342 ( R-HSA-168927 ) R-HSA-9014342 Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex See in Reactome R-HSA-9014343 ( R-HSA-168927 ) R-HSA-9014343 Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex See in Reactome R-HSA-933523 ( R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933526 ( R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933532 ( R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933539 ( R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-937029 ( R-HSA-937041 ) R-HSA-937029 Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1 See in Reactome R-HSA-9686336 ( R-HSA-5213460; R-HSA-9686347 ) R-HSA-9686336 Reaction Name: SARS-CoV-1 3a oligomerizes See in Reactome R-HSA-9686338 ( R-HSA-5213460; R-HSA-9686347 ) R-HSA-9686338 Reaction Name: SARS-CoV-1 3a binds the lysosomal membrane See in Reactome R-HSA-9686345 ( R-HSA-5213460; R-HSA-9686347 ) R-HSA-9686345 Reaction Name: SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer See in Reactome R-HSA-9686920 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9686920 Reaction Name: PELI1 ubiquitinates RIPK3 at K363 See in Reactome R-HSA-9686922 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9686922 Reaction Name: PELI1 binds activated RIPK1:RIPK3 See in Reactome R-HSA-9687465 ( R-HSA-5213460; R-HSA-9686347 ) R-HSA-9687465 Reaction Name: HSV1 RIR1 binds RIPK1 See in Reactome R-HSA-9687625 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9687625 Reaction Name: ATP binds MLKL See in Reactome R-HSA-9687638 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9687638 Reaction Name: MLKL binds IP4, IP5 and IP6 See in Reactome R-HSA-9688456 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9688456 Reaction Name: MLKL binds FLOT1, FLOT2 See in Reactome R-HSA-9688832 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9688832 Reaction Name: MLKL binds PDCD6IP and SDCBP See in Reactome R-HSA-9693978 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9693978 Reaction Name: Small molecule inhibitor binds RIPK1, RIPK3 See in Reactome R-HSA-9697747 ( R-HSA-5357905; R-HSA-75893 ) R-HSA-9697747 Reaction Name: Caspase-8 and FLIP(L) processing at TNFR signaling complex See in Reactome R-HSA-9697750 ( R-HSA-5357905; R-HSA-75893 ) R-HSA-9697750 Reaction Name: RIPK1 is cleaved by CASP8:FLIP(L) See in Reactome R-HSA-9701055 ( R-HSA-3295583 ) R-HSA-9701055 Reaction Name: TRPA1 tetramer transports Ca2+ from extracellular region to cytosol See in Reactome R-HSA-9701141 ( R-HSA-3295583 ) R-HSA-9701141 Reaction Name: TRPV1 transports Ca2+ from extracellular region to cytosol See in Reactome
MONDO:0030018	RIPK1	Q13546	2.7.11.1	R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-3295583 R-HSA-3295583 Reactome Name: TRP channels See in Reactome R-HSA-168927 R-HSA-168927 Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment See in Reactome R-HSA-9686347 R-HSA-9686347 Reactome Name: Microbial modulation of RIPK1-mediated regulated necrosis See in Reactome R-HSA-937041 R-HSA-937041 Reactome Name: IKK complex recruitment mediated by RIP1 See in Reactome R-HSA-5213460 R-HSA-5213460 Reactome Name: RIPK1-mediated regulated necrosis See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome R-HSA-5218900 R-HSA-5218900 Reactome Name: CASP8 activity is inhibited See in Reactome R-HSA-140534 R-HSA-140534 Reactome Name: Caspase activation via Death Receptors in the presence of ligand See in Reactome R-HSA-2562578 R-HSA-2562578 Reactome Name: TRIF-mediated programmed cell death See in Reactome R-HSA-5357956 R-HSA-5357956 Reactome Name: TNFR1-induced NFkappaB signaling pathway See in Reactome R-HSA-1810476 R-HSA-1810476 Reactome Name: RIP-mediated NFkB activation via ZBP1 See in Reactome R-HSA-69416 R-HSA-69416 Reactome Name: Dimerization of procaspase-8 See in Reactome R-HSA-5675482 R-HSA-5675482 Reactome Name: Regulation of necroptotic cell death See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-3371378 R-HSA-3371378 Reactome Name: Regulation by c-FLIP See in Reactome R-HSA-5357786 R-HSA-5357786 Reactome Name: TNFR1-induced proapoptotic signaling See in Reactome R-HSA-9013957 R-HSA-9013957 Reactome Name: TLR3-mediated TICAM1-dependent programmed cell death See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-1606322 R-HSA-1606322 Reactome Name: ZBP1(DAI) mediated induction of type I IFNs See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-983712 R-HSA-983712 Reactome Name: Ion channel transport See in Reactome R-HSA-5357769 R-HSA-5357769 Reactome Name: Caspase activation via extrinsic apoptotic signalling pathway See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-5218859 R-HSA-5218859 Reactome Name: Regulated Necrosis See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-2672351 R-HSA-2672351 Reactome Name: Stimuli-sensing channels See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Transport of small molecules Programmed Cell Death Metabolism of proteins Signal Transduction	R-HSA-139952 ( R-HSA-140534 ) R-HSA-139952 Reaction Name: Caspase-8 processing in the DISC See in Reactome R-HSA-140978 ( R-HSA-5357786; R-HSA-75893 ) R-HSA-140978 Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD See in Reactome R-HSA-141159 ( R-HSA-140534; R-HSA-69416 ) R-HSA-141159 Reaction Name: TNF-mediated dimerization of procaspase-8 See in Reactome R-HSA-168910 ( R-HSA-1810476 ) R-HSA-168910 Reaction Name: RIP1 facilitates IKK complex phosphorylation See in Reactome R-HSA-168915 ( R-HSA-937041 ) R-HSA-168915 Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex See in Reactome R-HSA-168921 ( R-HSA-937041 ) R-HSA-168921 Reaction Name: TRIF:activated TLR3/TLR4 complex recruits RIP1 See in Reactome R-HSA-168930 ( R-HSA-168927 ) R-HSA-168930 Reaction Name: Viral dsRNA:TLR3:TRIF complex recruits RIP1 See in Reactome R-HSA-168934 ( R-HSA-933543 ) R-HSA-168934 Reaction Name: MAVS interacts with RIPK1 and FADD See in Reactome R-HSA-1810457 ( R-HSA-1810476 ) R-HSA-1810457 Reaction Name: ZBP1(DAI) recruits RIP1 and RIP3 See in Reactome R-HSA-2562541 ( R-HSA-2562578 ) R-HSA-2562541 Reaction Name: TLR4-induced ripoptosome assembly See in Reactome R-HSA-2562564 ( R-HSA-140534; R-HSA-2562578 ) R-HSA-2562564 Reaction Name: Caspase-8 processing within TLR4 complex See in Reactome R-HSA-2569057 ( R-HSA-2562578 ) R-HSA-2569057 Reaction Name: RIP3 binds TRIF to mediate necroptosis See in Reactome R-HSA-3295579 ( R-HSA-3295583 ) R-HSA-3295579 Reaction Name: TRPs transport extracellular Ca2+ to cytosol See in Reactome R-HSA-3371360 ( R-HSA-140534; R-HSA-3371378; R-HSA-5357905; R-HSA-75893 ) R-HSA-3371360 Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling See in Reactome R-HSA-3465429 ( R-HSA-5213460; R-HSA-5218900; R-HSA-5675482 ) R-HSA-3465429 Reaction Name: FLIP(S) and procaspase-8 form heterodimer See in Reactome R-HSA-3465448 ( R-HSA-140534; R-HSA-3371378 ) R-HSA-3465448 Reaction Name: Caspase-8 and FLIP(L) processing at DISC See in Reactome R-HSA-5213462 ( R-HSA-5213460 ) R-HSA-5213462 Reaction Name: RIPK3 binds RIPK1 See in Reactome R-HSA-5213464 ( R-HSA-5213460 ) R-HSA-5213464 Reaction Name: RIPK1 is phosphorylated See in Reactome R-HSA-5213466 ( R-HSA-5213460 ) R-HSA-5213466 Reaction Name: RIPK3 is phosphorylated See in Reactome R-HSA-5218891 ( R-HSA-5213460 ) R-HSA-5218891 Reaction Name: RIPK1:RIPK3 oligomer binds MLKL See in Reactome R-HSA-5218905 ( R-HSA-5213460 ) R-HSA-5218905 Reaction Name: RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils See in Reactome R-HSA-5218906 ( R-HSA-5213460 ) R-HSA-5218906 Reaction Name: RIPK3 phosphorylates MLKL See in Reactome R-HSA-5357757 ( R-HSA-5357956; R-HSA-75893 ) R-HSA-5357757 Reaction Name: BIRC(cIAP1/2) ubiquitinates RIPK1 See in Reactome R-HSA-5357776 ( R-HSA-5357956; R-HSA-75893 ) R-HSA-5357776 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG See in Reactome R-HSA-5357780 ( R-HSA-5357956; R-HSA-75893 ) R-HSA-5357780 Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) See in Reactome R-HSA-5357828 ( R-HSA-5213460; R-HSA-5357905; R-HSA-5675482; R-HSA-75893 ) R-HSA-5357828 Reaction Name: RIPK1 is cleaved by CASP8 See in Reactome R-HSA-5357845 ( R-HSA-5357905; R-HSA-75893 ) R-HSA-5357845 Reaction Name: RIPK1 is deubiquitinated See in Reactome R-HSA-5357860 ( R-HSA-5357956; R-HSA-75893 ) R-HSA-5357860 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex See in Reactome R-HSA-5357904 ( R-HSA-5357956; R-HSA-75893 ) R-HSA-5357904 Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC See in Reactome R-HSA-5357927 ( R-HSA-5213460 ) R-HSA-5357927 Reaction Name: MLKL oligomerizes See in Reactome R-HSA-5357928 ( R-HSA-5357905; R-HSA-75893 ) R-HSA-5357928 Reaction Name: CLIP3 and CYLD bind TNF signaling complex See in Reactome R-HSA-5620975 ( R-HSA-5213460 ) R-HSA-5620975 Reaction Name: MLKL binds PIPs See in Reactome R-HSA-5634221 ( R-HSA-5357905; R-HSA-75893 ) R-HSA-5634221 Reaction Name: TRAF1 binds TRAF2 within TNFR1 signaling complex See in Reactome R-HSA-5675456 ( R-HSA-5213460; R-HSA-5218900; R-HSA-5675482 ) R-HSA-5675456 Reaction Name: FLIP(L) and procaspase-8 form heterodimer See in Reactome R-HSA-5690159 ( R-HSA-5689880 ) R-HSA-5690159 Reaction Name: USP21 deubiquitinates RIPK1,DDX58 See in Reactome R-HSA-5690827 ( R-HSA-5689896 ) R-HSA-5690827 Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 See in Reactome R-HSA-5690856 ( R-HSA-5689896 ) R-HSA-5690856 Reaction Name: TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 See in Reactome R-HSA-5693055 ( R-HSA-5357905; R-HSA-75893 ) R-HSA-5693055 Reaction Name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes See in Reactome R-HSA-5693108 ( R-HSA-5357905; R-HSA-75893 ) R-HSA-5693108 Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains See in Reactome R-HSA-5696627 ( R-HSA-5689880 ) R-HSA-5696627 Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG See in Reactome R-HSA-75240 ( R-HSA-5357786; R-HSA-75893 ) R-HSA-75240 Reaction Name: TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8 See in Reactome R-HSA-83582 ( R-HSA-5357786; R-HSA-75893 ) R-HSA-83582 Reaction Name: TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex. See in Reactome R-HSA-83656 ( R-HSA-75893 ) R-HSA-83656 Reaction Name: TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 See in Reactome R-HSA-9013889 ( R-HSA-9013957 ) R-HSA-9013889 Reaction Name: TLR3-induced ripoptosome assembly See in Reactome R-HSA-9013895 ( R-HSA-9013957 ) R-HSA-9013895 Reaction Name: Caspase-8 processing within TLR3 complex See in Reactome R-HSA-9013963 ( R-HSA-9013957 ) R-HSA-9013963 Reaction Name: RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis See in Reactome R-HSA-9014342 ( R-HSA-168927 ) R-HSA-9014342 Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex See in Reactome R-HSA-9014343 ( R-HSA-168927 ) R-HSA-9014343 Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex See in Reactome R-HSA-933523 ( R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933526 ( R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933532 ( R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933539 ( R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-937029 ( R-HSA-937041 ) R-HSA-937029 Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1 See in Reactome R-HSA-9686336 ( R-HSA-5213460; R-HSA-9686347 ) R-HSA-9686336 Reaction Name: SARS-CoV-1 3a oligomerizes See in Reactome R-HSA-9686338 ( R-HSA-5213460; R-HSA-9686347 ) R-HSA-9686338 Reaction Name: SARS-CoV-1 3a binds the lysosomal membrane See in Reactome R-HSA-9686345 ( R-HSA-5213460; R-HSA-9686347 ) R-HSA-9686345 Reaction Name: SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer See in Reactome R-HSA-9686920 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9686920 Reaction Name: PELI1 ubiquitinates RIPK3 at K363 See in Reactome R-HSA-9686922 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9686922 Reaction Name: PELI1 binds activated RIPK1:RIPK3 See in Reactome R-HSA-9687465 ( R-HSA-5213460; R-HSA-9686347 ) R-HSA-9687465 Reaction Name: HSV1 RIR1 binds RIPK1 See in Reactome R-HSA-9687625 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9687625 Reaction Name: ATP binds MLKL See in Reactome R-HSA-9687638 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9687638 Reaction Name: MLKL binds IP4, IP5 and IP6 See in Reactome R-HSA-9688456 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9688456 Reaction Name: MLKL binds FLOT1, FLOT2 See in Reactome R-HSA-9688832 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9688832 Reaction Name: MLKL binds PDCD6IP and SDCBP See in Reactome R-HSA-9693978 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9693978 Reaction Name: Small molecule inhibitor binds RIPK1, RIPK3 See in Reactome R-HSA-9697747 ( R-HSA-5357905; R-HSA-75893 ) R-HSA-9697747 Reaction Name: Caspase-8 and FLIP(L) processing at TNFR signaling complex See in Reactome R-HSA-9697750 ( R-HSA-5357905; R-HSA-75893 ) R-HSA-9697750 Reaction Name: RIPK1 is cleaved by CASP8:FLIP(L) See in Reactome R-HSA-9701055 ( R-HSA-3295583 ) R-HSA-9701055 Reaction Name: TRPA1 tetramer transports Ca2+ from extracellular region to cytosol See in Reactome R-HSA-9701141 ( R-HSA-3295583 ) R-HSA-9701141 Reaction Name: TRPV1 transports Ca2+ from extracellular region to cytosol See in Reactome
MONDO:0030872	CYLD	Q9NQC7	3.4.19.12	R-HSA-5357786 R-HSA-5357786 Reactome Name: TNFR1-induced proapoptotic signaling See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-5357956 R-HSA-5357956 Reactome Name: TNFR1-induced NFkappaB signaling pathway See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome	R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism of proteins Signal Transduction	R-HSA-140978 ( R-HSA-5357786 ) R-HSA-140978 Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD See in Reactome R-HSA-5357776 ( R-HSA-5357956 ) R-HSA-5357776 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG See in Reactome R-HSA-5357831 ( R-HSA-5357905 ) R-HSA-5357831 Reaction Name: CYLD is phosphorylated by IKK See in Reactome R-HSA-5357845 ( R-HSA-5357905 ) R-HSA-5357845 Reaction Name: RIPK1 is deubiquitinated See in Reactome R-HSA-5357860 ( R-HSA-5357956 ) R-HSA-5357860 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex See in Reactome R-HSA-5357928 ( R-HSA-5357905 ) R-HSA-5357928 Reaction Name: CLIP3 and CYLD bind TNF signaling complex See in Reactome R-HSA-5696627 ( R-HSA-5689880 ) R-HSA-5696627 Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG See in Reactome R-HSA-741411 ( R-HSA-168638 ) R-HSA-741411 Reaction Name: CYLD deubiquitinates NEMO See in Reactome R-HSA-936390 ( R-HSA-5689880; R-HSA-936440 ) R-HSA-936390 Reaction Name: CYLD mediated deubiquitination of DDX58 (RIG-I) See in Reactome
MONDO:0033968	RIPK1	Q13546	2.7.11.1	R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-3295583 R-HSA-3295583 Reactome Name: TRP channels See in Reactome R-HSA-168927 R-HSA-168927 Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment See in Reactome R-HSA-9686347 R-HSA-9686347 Reactome Name: Microbial modulation of RIPK1-mediated regulated necrosis See in Reactome R-HSA-937041 R-HSA-937041 Reactome Name: IKK complex recruitment mediated by RIP1 See in Reactome R-HSA-5213460 R-HSA-5213460 Reactome Name: RIPK1-mediated regulated necrosis See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome R-HSA-5218900 R-HSA-5218900 Reactome Name: CASP8 activity is inhibited See in Reactome R-HSA-140534 R-HSA-140534 Reactome Name: Caspase activation via Death Receptors in the presence of ligand See in Reactome R-HSA-2562578 R-HSA-2562578 Reactome Name: TRIF-mediated programmed cell death See in Reactome R-HSA-5357956 R-HSA-5357956 Reactome Name: TNFR1-induced NFkappaB signaling pathway See in Reactome R-HSA-1810476 R-HSA-1810476 Reactome Name: RIP-mediated NFkB activation via ZBP1 See in Reactome R-HSA-69416 R-HSA-69416 Reactome Name: Dimerization of procaspase-8 See in Reactome R-HSA-5675482 R-HSA-5675482 Reactome Name: Regulation of necroptotic cell death See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-3371378 R-HSA-3371378 Reactome Name: Regulation by c-FLIP See in Reactome R-HSA-5357786 R-HSA-5357786 Reactome Name: TNFR1-induced proapoptotic signaling See in Reactome R-HSA-9013957 R-HSA-9013957 Reactome Name: TLR3-mediated TICAM1-dependent programmed cell death See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-1606322 R-HSA-1606322 Reactome Name: ZBP1(DAI) mediated induction of type I IFNs See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-983712 R-HSA-983712 Reactome Name: Ion channel transport See in Reactome R-HSA-5357769 R-HSA-5357769 Reactome Name: Caspase activation via extrinsic apoptotic signalling pathway See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-5218859 R-HSA-5218859 Reactome Name: Regulated Necrosis See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-2672351 R-HSA-2672351 Reactome Name: Stimuli-sensing channels See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Transport of small molecules Programmed Cell Death Metabolism of proteins Signal Transduction	R-HSA-139952 ( R-HSA-140534 ) R-HSA-139952 Reaction Name: Caspase-8 processing in the DISC See in Reactome R-HSA-140978 ( R-HSA-5357786; R-HSA-75893 ) R-HSA-140978 Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD See in Reactome R-HSA-141159 ( R-HSA-140534; R-HSA-69416 ) R-HSA-141159 Reaction Name: TNF-mediated dimerization of procaspase-8 See in Reactome R-HSA-168910 ( R-HSA-1810476 ) R-HSA-168910 Reaction Name: RIP1 facilitates IKK complex phosphorylation See in Reactome R-HSA-168915 ( R-HSA-937041 ) R-HSA-168915 Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex See in Reactome R-HSA-168921 ( R-HSA-937041 ) R-HSA-168921 Reaction Name: TRIF:activated TLR3/TLR4 complex recruits RIP1 See in Reactome R-HSA-168930 ( R-HSA-168927 ) R-HSA-168930 Reaction Name: Viral dsRNA:TLR3:TRIF complex recruits RIP1 See in Reactome R-HSA-168934 ( R-HSA-933543 ) R-HSA-168934 Reaction Name: MAVS interacts with RIPK1 and FADD See in Reactome R-HSA-1810457 ( R-HSA-1810476 ) R-HSA-1810457 Reaction Name: ZBP1(DAI) recruits RIP1 and RIP3 See in Reactome R-HSA-2562541 ( R-HSA-2562578 ) R-HSA-2562541 Reaction Name: TLR4-induced ripoptosome assembly See in Reactome R-HSA-2562564 ( R-HSA-140534; R-HSA-2562578 ) R-HSA-2562564 Reaction Name: Caspase-8 processing within TLR4 complex See in Reactome R-HSA-2569057 ( R-HSA-2562578 ) R-HSA-2569057 Reaction Name: RIP3 binds TRIF to mediate necroptosis See in Reactome R-HSA-3295579 ( R-HSA-3295583 ) R-HSA-3295579 Reaction Name: TRPs transport extracellular Ca2+ to cytosol See in Reactome R-HSA-3371360 ( R-HSA-140534; R-HSA-3371378; R-HSA-5357905; R-HSA-75893 ) R-HSA-3371360 Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling See in Reactome R-HSA-3465429 ( R-HSA-5213460; R-HSA-5218900; R-HSA-5675482 ) R-HSA-3465429 Reaction Name: FLIP(S) and procaspase-8 form heterodimer See in Reactome R-HSA-3465448 ( R-HSA-140534; R-HSA-3371378 ) R-HSA-3465448 Reaction Name: Caspase-8 and FLIP(L) processing at DISC See in Reactome R-HSA-5213462 ( R-HSA-5213460 ) R-HSA-5213462 Reaction Name: RIPK3 binds RIPK1 See in Reactome R-HSA-5213464 ( R-HSA-5213460 ) R-HSA-5213464 Reaction Name: RIPK1 is phosphorylated See in Reactome R-HSA-5213466 ( R-HSA-5213460 ) R-HSA-5213466 Reaction Name: RIPK3 is phosphorylated See in Reactome R-HSA-5218891 ( R-HSA-5213460 ) R-HSA-5218891 Reaction Name: RIPK1:RIPK3 oligomer binds MLKL See in Reactome R-HSA-5218905 ( R-HSA-5213460 ) R-HSA-5218905 Reaction Name: RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils See in Reactome R-HSA-5218906 ( R-HSA-5213460 ) R-HSA-5218906 Reaction Name: RIPK3 phosphorylates MLKL See in Reactome R-HSA-5357757 ( R-HSA-5357956; R-HSA-75893 ) R-HSA-5357757 Reaction Name: BIRC(cIAP1/2) ubiquitinates RIPK1 See in Reactome R-HSA-5357776 ( R-HSA-5357956; R-HSA-75893 ) R-HSA-5357776 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG See in Reactome R-HSA-5357780 ( R-HSA-5357956; R-HSA-75893 ) R-HSA-5357780 Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) See in Reactome R-HSA-5357828 ( R-HSA-5213460; R-HSA-5357905; R-HSA-5675482; R-HSA-75893 ) R-HSA-5357828 Reaction Name: RIPK1 is cleaved by CASP8 See in Reactome R-HSA-5357845 ( R-HSA-5357905; R-HSA-75893 ) R-HSA-5357845 Reaction Name: RIPK1 is deubiquitinated See in Reactome R-HSA-5357860 ( R-HSA-5357956; R-HSA-75893 ) R-HSA-5357860 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex See in Reactome R-HSA-5357904 ( R-HSA-5357956; R-HSA-75893 ) R-HSA-5357904 Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC See in Reactome R-HSA-5357927 ( R-HSA-5213460 ) R-HSA-5357927 Reaction Name: MLKL oligomerizes See in Reactome R-HSA-5357928 ( R-HSA-5357905; R-HSA-75893 ) R-HSA-5357928 Reaction Name: CLIP3 and CYLD bind TNF signaling complex See in Reactome R-HSA-5620975 ( R-HSA-5213460 ) R-HSA-5620975 Reaction Name: MLKL binds PIPs See in Reactome R-HSA-5634221 ( R-HSA-5357905; R-HSA-75893 ) R-HSA-5634221 Reaction Name: TRAF1 binds TRAF2 within TNFR1 signaling complex See in Reactome R-HSA-5675456 ( R-HSA-5213460; R-HSA-5218900; R-HSA-5675482 ) R-HSA-5675456 Reaction Name: FLIP(L) and procaspase-8 form heterodimer See in Reactome R-HSA-5690159 ( R-HSA-5689880 ) R-HSA-5690159 Reaction Name: USP21 deubiquitinates RIPK1,DDX58 See in Reactome R-HSA-5690827 ( R-HSA-5689896 ) R-HSA-5690827 Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 See in Reactome R-HSA-5690856 ( R-HSA-5689896 ) R-HSA-5690856 Reaction Name: TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 See in Reactome R-HSA-5693055 ( R-HSA-5357905; R-HSA-75893 ) R-HSA-5693055 Reaction Name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes See in Reactome R-HSA-5693108 ( R-HSA-5357905; R-HSA-75893 ) R-HSA-5693108 Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains See in Reactome R-HSA-5696627 ( R-HSA-5689880 ) R-HSA-5696627 Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG See in Reactome R-HSA-75240 ( R-HSA-5357786; R-HSA-75893 ) R-HSA-75240 Reaction Name: TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8 See in Reactome R-HSA-83582 ( R-HSA-5357786; R-HSA-75893 ) R-HSA-83582 Reaction Name: TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex. See in Reactome R-HSA-83656 ( R-HSA-75893 ) R-HSA-83656 Reaction Name: TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 See in Reactome R-HSA-9013889 ( R-HSA-9013957 ) R-HSA-9013889 Reaction Name: TLR3-induced ripoptosome assembly See in Reactome R-HSA-9013895 ( R-HSA-9013957 ) R-HSA-9013895 Reaction Name: Caspase-8 processing within TLR3 complex See in Reactome R-HSA-9013963 ( R-HSA-9013957 ) R-HSA-9013963 Reaction Name: RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis See in Reactome R-HSA-9014342 ( R-HSA-168927 ) R-HSA-9014342 Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex See in Reactome R-HSA-9014343 ( R-HSA-168927 ) R-HSA-9014343 Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex See in Reactome R-HSA-933523 ( R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933526 ( R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933532 ( R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933539 ( R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-937029 ( R-HSA-937041 ) R-HSA-937029 Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1 See in Reactome R-HSA-9686336 ( R-HSA-5213460; R-HSA-9686347 ) R-HSA-9686336 Reaction Name: SARS-CoV-1 3a oligomerizes See in Reactome R-HSA-9686338 ( R-HSA-5213460; R-HSA-9686347 ) R-HSA-9686338 Reaction Name: SARS-CoV-1 3a binds the lysosomal membrane See in Reactome R-HSA-9686345 ( R-HSA-5213460; R-HSA-9686347 ) R-HSA-9686345 Reaction Name: SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer See in Reactome R-HSA-9686920 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9686920 Reaction Name: PELI1 ubiquitinates RIPK3 at K363 See in Reactome R-HSA-9686922 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9686922 Reaction Name: PELI1 binds activated RIPK1:RIPK3 See in Reactome R-HSA-9687465 ( R-HSA-5213460; R-HSA-9686347 ) R-HSA-9687465 Reaction Name: HSV1 RIR1 binds RIPK1 See in Reactome R-HSA-9687625 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9687625 Reaction Name: ATP binds MLKL See in Reactome R-HSA-9687638 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9687638 Reaction Name: MLKL binds IP4, IP5 and IP6 See in Reactome R-HSA-9688456 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9688456 Reaction Name: MLKL binds FLOT1, FLOT2 See in Reactome R-HSA-9688832 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9688832 Reaction Name: MLKL binds PDCD6IP and SDCBP See in Reactome R-HSA-9693978 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9693978 Reaction Name: Small molecule inhibitor binds RIPK1, RIPK3 See in Reactome R-HSA-9697747 ( R-HSA-5357905; R-HSA-75893 ) R-HSA-9697747 Reaction Name: Caspase-8 and FLIP(L) processing at TNFR signaling complex See in Reactome R-HSA-9697750 ( R-HSA-5357905; R-HSA-75893 ) R-HSA-9697750 Reaction Name: RIPK1 is cleaved by CASP8:FLIP(L) See in Reactome R-HSA-9701055 ( R-HSA-3295583 ) R-HSA-9701055 Reaction Name: TRPA1 tetramer transports Ca2+ from extracellular region to cytosol See in Reactome R-HSA-9701141 ( R-HSA-3295583 ) R-HSA-9701141 Reaction Name: TRPV1 transports Ca2+ from extracellular region to cytosol See in Reactome
MONDO:0042977	CYLD	Q9NQC7	3.4.19.12	R-HSA-5357786 R-HSA-5357786 Reactome Name: TNFR1-induced proapoptotic signaling See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-5357956 R-HSA-5357956 Reactome Name: TNFR1-induced NFkappaB signaling pathway See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome	R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism of proteins Signal Transduction	R-HSA-140978 ( R-HSA-5357786 ) R-HSA-140978 Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD See in Reactome R-HSA-5357776 ( R-HSA-5357956 ) R-HSA-5357776 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG See in Reactome R-HSA-5357831 ( R-HSA-5357905 ) R-HSA-5357831 Reaction Name: CYLD is phosphorylated by IKK See in Reactome R-HSA-5357845 ( R-HSA-5357905 ) R-HSA-5357845 Reaction Name: RIPK1 is deubiquitinated See in Reactome R-HSA-5357860 ( R-HSA-5357956 ) R-HSA-5357860 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex See in Reactome R-HSA-5357928 ( R-HSA-5357905 ) R-HSA-5357928 Reaction Name: CLIP3 and CYLD bind TNF signaling complex See in Reactome R-HSA-5696627 ( R-HSA-5689880 ) R-HSA-5696627 Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG See in Reactome R-HSA-741411 ( R-HSA-168638 ) R-HSA-741411 Reaction Name: CYLD deubiquitinates NEMO See in Reactome R-HSA-936390 ( R-HSA-5689880; R-HSA-936440 ) R-HSA-936390 Reaction Name: CYLD mediated deubiquitination of DDX58 (RIG-I) See in Reactome