MONDO:0007565 |
CYLD |
Q9NQC7 |
3.4.19.12
|
R-HSA-5357786
R-HSA-5357786
Reactome Name: TNFR1-induced proapoptotic signaling
See in Reactome
R-HSA-168638
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-936440
R-HSA-936440
Reactome Name: Negative regulators of DDX58/IFIH1 signaling
See in Reactome
R-HSA-5357905
|
R-HSA-5688426
R-HSA-168256
R-HSA-392499
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-73887
R-HSA-75893
R-HSA-168249
R-HSA-162582
|
Immune System
Metabolism of proteins
Signal Transduction
|
R-HSA-140978
(
R-HSA-5357786
)
R-HSA-140978
Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD
See in Reactome
R-HSA-5357776
(
R-HSA-5357956
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357831
(
R-HSA-5357905
)
R-HSA-5357845
(
R-HSA-5357905
)
R-HSA-5357860
(
R-HSA-5357956
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5357928
(
R-HSA-5357905
)
R-HSA-5357928
Reaction Name: CLIP3 and CYLD bind TNF signaling complex
See in Reactome
R-HSA-5696627
(
R-HSA-5689880
)
R-HSA-5696627
Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
See in Reactome
R-HSA-741411
(
R-HSA-168638
)
R-HSA-936390
(
R-HSA-5689880;
R-HSA-936440
)
R-HSA-936390
Reaction Name: CYLD mediated deubiquitination of DDX58 (RIG-I)
See in Reactome
|
MONDO:0011804 |
CASP8 |
Q14790 |
3.4.22.61
|
R-HSA-75153
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-75158
R-HSA-75108
R-HSA-75108
Reactome Name: Activation, myristolyation of BID and translocation to mitochondria
See in Reactome
R-HSA-9686347
R-HSA-9686347
Reactome Name: Microbial modulation of RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-264870
R-HSA-264870
Reactome Name: Caspase-mediated cleavage of cytoskeletal proteins
See in Reactome
R-HSA-111465
R-HSA-111465
Reactome Name: Apoptotic cleavage of cellular proteins
See in Reactome
R-HSA-5213460
R-HSA-5213460
Reactome Name: RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-168638
R-HSA-5660668
R-HSA-5357905
R-HSA-5218900
R-HSA-140534
R-HSA-140534
Reactome Name: Caspase activation via Death Receptors in the presence of ligand
See in Reactome
R-HSA-2562578
R-HSA-2562578
Reactome Name: TRIF-mediated programmed cell death
See in Reactome
R-HSA-75157
R-HSA-69416
R-HSA-5675482
R-HSA-5675482
Reactome Name: Regulation of necroptotic cell death
See in Reactome
R-HSA-3371378
R-HSA-5357786
R-HSA-5357786
Reactome Name: TNFR1-induced proapoptotic signaling
See in Reactome
R-HSA-9013957
R-HSA-9013957
Reactome Name: TLR3-mediated TICAM1-dependent programmed cell death
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-168256
R-HSA-5357769
R-HSA-5357769
Reactome Name: Caspase activation via extrinsic apoptotic signalling pathway
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168898
R-HSA-166166
R-HSA-5357801
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-162582
R-HSA-75893
R-HSA-73887
R-HSA-5607764
R-HSA-168249
R-HSA-5218859
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109581
|
Immune System
Programmed Cell Death
Signal Transduction
|
R-HSA-139898
(
R-HSA-75108
)
R-HSA-139898
Reaction Name: Caspase-8 activates BID by cleavage
See in Reactome
R-HSA-139952
(
R-HSA-140534
)
R-HSA-139952
Reaction Name: Caspase-8 processing in the DISC
See in Reactome
R-HSA-141156
(
R-HSA-140534;
R-HSA-69416
)
R-HSA-141156
Reaction Name: TRAIL-mediated dimerization of procaspase-8
See in Reactome
R-HSA-141159
(
R-HSA-140534;
R-HSA-69416
)
R-HSA-141159
Reaction Name: TNF-mediated dimerization of procaspase-8
See in Reactome
R-HSA-201637
(
R-HSA-111465;
R-HSA-264870;
R-HSA-75153
)
R-HSA-201637
Reaction Name: Caspase-mediated cleavage of plectin-1
See in Reactome
R-HSA-2562541
(
R-HSA-2562578
)
R-HSA-2562541
Reaction Name: TLR4-induced ripoptosome assembly
See in Reactome
R-HSA-2562564
(
R-HSA-140534;
R-HSA-2562578
)
R-HSA-2562564
Reaction Name: Caspase-8 processing within TLR4 complex
See in Reactome
R-HSA-2672196
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5357905;
R-HSA-5675482;
R-HSA-75893;
R-HSA-9686347
)
R-HSA-2672196
Reaction Name: Viral serpin blocks caspase-8 activity
See in Reactome
R-HSA-3371359
(
R-HSA-140534;
R-HSA-3371378
)
R-HSA-3371359
Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling
See in Reactome
R-HSA-3371360
(
R-HSA-140534;
R-HSA-3371378;
R-HSA-5357905;
R-HSA-75893
)
R-HSA-3371360
Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling
See in Reactome
R-HSA-3465429
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5675482
)
R-HSA-3465429
Reaction Name: FLIP(S) and procaspase-8 form heterodimer
See in Reactome
R-HSA-3465448
(
R-HSA-140534;
R-HSA-3371378
)
R-HSA-3465448
Reaction Name: Caspase-8 and FLIP(L) processing at DISC
See in Reactome
R-HSA-3465459
(
R-HSA-140534;
R-HSA-3371378
)
R-HSA-3465459
Reaction Name: FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling
See in Reactome
R-HSA-350319
(
R-HSA-111465;
R-HSA-264870;
R-HSA-75153
)
R-HSA-350319
Reaction Name: Caspase mediated cleavage of vimentin at IDVD (259)
See in Reactome
R-HSA-351863
(
R-HSA-75153
)
R-HSA-351863
Reaction Name: Translocation of active caspase-8 to the mitochondrial membrane
See in Reactome
R-HSA-351894
(
R-HSA-111465;
R-HSA-75153
)
R-HSA-351894
Reaction Name: Caspase mediated cleavage of BAP31
See in Reactome
R-HSA-5213462
(
R-HSA-5213460
)
R-HSA-5357828
(
R-HSA-5213460;
R-HSA-5357905;
R-HSA-5675482;
R-HSA-75893
)
R-HSA-5634228
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5660662
(
R-HSA-5660668
)
R-HSA-5660663
(
R-HSA-5660668
)
R-HSA-5660663
Reaction Name: Caspase-8 cleaves IL1B precursor
See in Reactome
R-HSA-5660665
(
R-HSA-5660668
)
R-HSA-5675456
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5675482
)
R-HSA-5675456
Reaction Name: FLIP(L) and procaspase-8 form heterodimer
See in Reactome
R-HSA-5692550
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5692550
Reaction Name: Viral inhibitor of caspase-8 activation (UL36) binds caspase-8
See in Reactome
R-HSA-622420
(
R-HSA-168638
)
R-HSA-622420
Reaction Name: NOD1 induced apoptosis is mediated by RIP2 and CARD8
See in Reactome
R-HSA-73945
(
R-HSA-140534;
R-HSA-69416
)
R-HSA-73945
Reaction Name: FAS-mediated dimerization of procaspase-8
See in Reactome
R-HSA-75146
(
R-HSA-75158
)
R-HSA-75146
Reaction Name: TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8
See in Reactome
R-HSA-75240
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-75240
Reaction Name: TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8
See in Reactome
R-HSA-83586
(
R-HSA-75157
)
R-HSA-83586
Reaction Name: FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8
See in Reactome
R-HSA-9013889
(
R-HSA-9013957
)
R-HSA-9013889
Reaction Name: TLR3-induced ripoptosome assembly
See in Reactome
R-HSA-9013895
(
R-HSA-9013957
)
R-HSA-9013895
Reaction Name: Caspase-8 processing within TLR3 complex
See in Reactome
R-HSA-933523
(
R-HSA-933543
)
R-HSA-933523
Reaction Name: Dimerzation of procaspase-8, procaspase-10
See in Reactome
R-HSA-933526
(
R-HSA-933543
)
R-HSA-933526
Reaction Name: Recruitment of caspase-8 and -10 to FADD complex
See in Reactome
R-HSA-933532
(
R-HSA-933543
)
R-HSA-933539
(
R-HSA-933543
)
R-HSA-9686930
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9687458
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9697747
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-9697747
Reaction Name: Caspase-8 and FLIP(L) processing at TNFR signaling complex
See in Reactome
R-HSA-9697750
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-9697750
Reaction Name: RIPK1 is cleaved by CASP8:FLIP(L)
See in Reactome
|
MONDO:0014761 |
TNFAIP3 |
P21580 |
2.3.2.-
3.4.19.12
|
R-HSA-5357786
R-HSA-5357786
Reactome Name: TNFR1-induced proapoptotic signaling
See in Reactome
R-HSA-168638
R-HSA-5357905
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-936440
R-HSA-936440
Reactome Name: Negative regulators of DDX58/IFIH1 signaling
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
|
R-HSA-5688426
R-HSA-168256
R-HSA-392499
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-73887
R-HSA-75893
R-HSA-168249
R-HSA-162582
|
Immune System
Metabolism of proteins
Signal Transduction
|
R-HSA-140978
(
R-HSA-5357786
)
R-HSA-140978
Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD
See in Reactome
R-HSA-5357776
(
R-HSA-5357956
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357845
(
R-HSA-5357905
)
R-HSA-5357860
(
R-HSA-5357956
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5690827
(
R-HSA-5689896
)
R-HSA-5690827
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1
See in Reactome
R-HSA-5690845
(
R-HSA-5689896
)
R-HSA-5690856
(
R-HSA-5689896
)
R-HSA-5690856
Reaction Name: TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1
See in Reactome
R-HSA-5690870
(
R-HSA-5689896
)
R-HSA-5690870
Reaction Name: OTUD7B,TNFAIP3 deubiquitinate TRAF6
See in Reactome
R-HSA-5693055
(
R-HSA-5357905
)
R-HSA-5693055
Reaction Name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes
See in Reactome
R-HSA-5693108
(
R-HSA-5357905
)
R-HSA-5693108
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains
See in Reactome
R-HSA-688136
(
R-HSA-168638;
R-HSA-5689896
)
R-HSA-688136
Reaction Name: TNFAIP3 (A20) deubiquitinates RIP2
See in Reactome
R-HSA-8869506
(
R-HSA-5689896
)
R-HSA-8869506
Reaction Name: TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6
See in Reactome
R-HSA-937337
(
R-HSA-936440
)
R-HSA-937337
Reaction Name: TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination
See in Reactome
|
MONDO:0016216 |
CASP8 |
Q14790 |
3.4.22.61
|
R-HSA-75153
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-75158
R-HSA-75108
R-HSA-75108
Reactome Name: Activation, myristolyation of BID and translocation to mitochondria
See in Reactome
R-HSA-9686347
R-HSA-9686347
Reactome Name: Microbial modulation of RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-264870
R-HSA-264870
Reactome Name: Caspase-mediated cleavage of cytoskeletal proteins
See in Reactome
R-HSA-111465
R-HSA-111465
Reactome Name: Apoptotic cleavage of cellular proteins
See in Reactome
R-HSA-5213460
R-HSA-5213460
Reactome Name: RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-168638
R-HSA-5660668
R-HSA-5357905
R-HSA-5218900
R-HSA-140534
R-HSA-140534
Reactome Name: Caspase activation via Death Receptors in the presence of ligand
See in Reactome
R-HSA-2562578
R-HSA-2562578
Reactome Name: TRIF-mediated programmed cell death
See in Reactome
R-HSA-75157
R-HSA-69416
R-HSA-5675482
R-HSA-5675482
Reactome Name: Regulation of necroptotic cell death
See in Reactome
R-HSA-3371378
R-HSA-5357786
R-HSA-5357786
Reactome Name: TNFR1-induced proapoptotic signaling
See in Reactome
R-HSA-9013957
R-HSA-9013957
Reactome Name: TLR3-mediated TICAM1-dependent programmed cell death
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-168256
R-HSA-5357769
R-HSA-5357769
Reactome Name: Caspase activation via extrinsic apoptotic signalling pathway
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168898
R-HSA-166166
R-HSA-5357801
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-162582
R-HSA-75893
R-HSA-73887
R-HSA-5607764
R-HSA-168249
R-HSA-5218859
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109581
|
Immune System
Programmed Cell Death
Signal Transduction
|
R-HSA-139898
(
R-HSA-75108
)
R-HSA-139898
Reaction Name: Caspase-8 activates BID by cleavage
See in Reactome
R-HSA-139952
(
R-HSA-140534
)
R-HSA-139952
Reaction Name: Caspase-8 processing in the DISC
See in Reactome
R-HSA-141156
(
R-HSA-140534;
R-HSA-69416
)
R-HSA-141156
Reaction Name: TRAIL-mediated dimerization of procaspase-8
See in Reactome
R-HSA-141159
(
R-HSA-140534;
R-HSA-69416
)
R-HSA-141159
Reaction Name: TNF-mediated dimerization of procaspase-8
See in Reactome
R-HSA-201637
(
R-HSA-111465;
R-HSA-264870;
R-HSA-75153
)
R-HSA-201637
Reaction Name: Caspase-mediated cleavage of plectin-1
See in Reactome
R-HSA-2562541
(
R-HSA-2562578
)
R-HSA-2562541
Reaction Name: TLR4-induced ripoptosome assembly
See in Reactome
R-HSA-2562564
(
R-HSA-140534;
R-HSA-2562578
)
R-HSA-2562564
Reaction Name: Caspase-8 processing within TLR4 complex
See in Reactome
R-HSA-2672196
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5357905;
R-HSA-5675482;
R-HSA-75893;
R-HSA-9686347
)
R-HSA-2672196
Reaction Name: Viral serpin blocks caspase-8 activity
See in Reactome
R-HSA-3371359
(
R-HSA-140534;
R-HSA-3371378
)
R-HSA-3371359
Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling
See in Reactome
R-HSA-3371360
(
R-HSA-140534;
R-HSA-3371378;
R-HSA-5357905;
R-HSA-75893
)
R-HSA-3371360
Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling
See in Reactome
R-HSA-3465429
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5675482
)
R-HSA-3465429
Reaction Name: FLIP(S) and procaspase-8 form heterodimer
See in Reactome
R-HSA-3465448
(
R-HSA-140534;
R-HSA-3371378
)
R-HSA-3465448
Reaction Name: Caspase-8 and FLIP(L) processing at DISC
See in Reactome
R-HSA-3465459
(
R-HSA-140534;
R-HSA-3371378
)
R-HSA-3465459
Reaction Name: FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling
See in Reactome
R-HSA-350319
(
R-HSA-111465;
R-HSA-264870;
R-HSA-75153
)
R-HSA-350319
Reaction Name: Caspase mediated cleavage of vimentin at IDVD (259)
See in Reactome
R-HSA-351863
(
R-HSA-75153
)
R-HSA-351863
Reaction Name: Translocation of active caspase-8 to the mitochondrial membrane
See in Reactome
R-HSA-351894
(
R-HSA-111465;
R-HSA-75153
)
R-HSA-351894
Reaction Name: Caspase mediated cleavage of BAP31
See in Reactome
R-HSA-5213462
(
R-HSA-5213460
)
R-HSA-5357828
(
R-HSA-5213460;
R-HSA-5357905;
R-HSA-5675482;
R-HSA-75893
)
R-HSA-5634228
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5660662
(
R-HSA-5660668
)
R-HSA-5660663
(
R-HSA-5660668
)
R-HSA-5660663
Reaction Name: Caspase-8 cleaves IL1B precursor
See in Reactome
R-HSA-5660665
(
R-HSA-5660668
)
R-HSA-5675456
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5675482
)
R-HSA-5675456
Reaction Name: FLIP(L) and procaspase-8 form heterodimer
See in Reactome
R-HSA-5692550
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5692550
Reaction Name: Viral inhibitor of caspase-8 activation (UL36) binds caspase-8
See in Reactome
R-HSA-622420
(
R-HSA-168638
)
R-HSA-622420
Reaction Name: NOD1 induced apoptosis is mediated by RIP2 and CARD8
See in Reactome
R-HSA-73945
(
R-HSA-140534;
R-HSA-69416
)
R-HSA-73945
Reaction Name: FAS-mediated dimerization of procaspase-8
See in Reactome
R-HSA-75146
(
R-HSA-75158
)
R-HSA-75146
Reaction Name: TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8
See in Reactome
R-HSA-75240
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-75240
Reaction Name: TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8
See in Reactome
R-HSA-83586
(
R-HSA-75157
)
R-HSA-83586
Reaction Name: FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8
See in Reactome
R-HSA-9013889
(
R-HSA-9013957
)
R-HSA-9013889
Reaction Name: TLR3-induced ripoptosome assembly
See in Reactome
R-HSA-9013895
(
R-HSA-9013957
)
R-HSA-9013895
Reaction Name: Caspase-8 processing within TLR3 complex
See in Reactome
R-HSA-933523
(
R-HSA-933543
)
R-HSA-933523
Reaction Name: Dimerzation of procaspase-8, procaspase-10
See in Reactome
R-HSA-933526
(
R-HSA-933543
)
R-HSA-933526
Reaction Name: Recruitment of caspase-8 and -10 to FADD complex
See in Reactome
R-HSA-933532
(
R-HSA-933543
)
R-HSA-933539
(
R-HSA-933543
)
R-HSA-9686930
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9687458
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9697747
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-9697747
Reaction Name: Caspase-8 and FLIP(L) processing at TNFR signaling complex
See in Reactome
R-HSA-9697750
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-9697750
Reaction Name: RIPK1 is cleaved by CASP8:FLIP(L)
See in Reactome
|
MONDO:0020849 |
RIPK1 |
Q13546 |
2.7.11.1
|
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-3295583
R-HSA-168927
R-HSA-168927
Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment
See in Reactome
R-HSA-9686347
R-HSA-9686347
Reactome Name: Microbial modulation of RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-937041
R-HSA-937041
Reactome Name: IKK complex recruitment mediated by RIP1
See in Reactome
R-HSA-5213460
R-HSA-5213460
Reactome Name: RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5357905
R-HSA-5218900
R-HSA-140534
R-HSA-140534
Reactome Name: Caspase activation via Death Receptors in the presence of ligand
See in Reactome
R-HSA-2562578
R-HSA-2562578
Reactome Name: TRIF-mediated programmed cell death
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-1810476
R-HSA-1810476
Reactome Name: RIP-mediated NFkB activation via ZBP1
See in Reactome
R-HSA-69416
R-HSA-5675482
R-HSA-5675482
Reactome Name: Regulation of necroptotic cell death
See in Reactome
R-HSA-75893
R-HSA-3371378
R-HSA-5357786
R-HSA-5357786
Reactome Name: TNFR1-induced proapoptotic signaling
See in Reactome
R-HSA-9013957
R-HSA-9013957
Reactome Name: TLR3-mediated TICAM1-dependent programmed cell death
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-168256
R-HSA-382551
R-HSA-5357801
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168898
R-HSA-166166
R-HSA-1606322
R-HSA-1606322
Reactome Name: ZBP1(DAI) mediated induction of type I IFNs
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-983712
R-HSA-5357769
R-HSA-5357769
Reactome Name: Caspase activation via extrinsic apoptotic signalling pathway
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-5218859
R-HSA-73887
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
R-HSA-5688426
R-HSA-109581
R-HSA-2672351
R-HSA-162582
|
Immune System
Transport of small molecules
Programmed Cell Death
Metabolism of proteins
Signal Transduction
|
R-HSA-139952
(
R-HSA-140534
)
R-HSA-139952
Reaction Name: Caspase-8 processing in the DISC
See in Reactome
R-HSA-140978
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-140978
Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD
See in Reactome
R-HSA-141159
(
R-HSA-140534;
R-HSA-69416
)
R-HSA-141159
Reaction Name: TNF-mediated dimerization of procaspase-8
See in Reactome
R-HSA-168910
(
R-HSA-1810476
)
R-HSA-168910
Reaction Name: RIP1 facilitates IKK complex phosphorylation
See in Reactome
R-HSA-168915
(
R-HSA-937041
)
R-HSA-168915
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-168921
(
R-HSA-937041
)
R-HSA-168921
Reaction Name: TRIF:activated TLR3/TLR4 complex recruits RIP1
See in Reactome
R-HSA-168930
(
R-HSA-168927
)
R-HSA-168930
Reaction Name: Viral dsRNA:TLR3:TRIF complex recruits RIP1
See in Reactome
R-HSA-168934
(
R-HSA-933543
)
R-HSA-168934
Reaction Name: MAVS interacts with RIPK1 and FADD
See in Reactome
R-HSA-1810457
(
R-HSA-1810476
)
R-HSA-1810457
Reaction Name: ZBP1(DAI) recruits RIP1 and RIP3
See in Reactome
R-HSA-2562541
(
R-HSA-2562578
)
R-HSA-2562541
Reaction Name: TLR4-induced ripoptosome assembly
See in Reactome
R-HSA-2562564
(
R-HSA-140534;
R-HSA-2562578
)
R-HSA-2562564
Reaction Name: Caspase-8 processing within TLR4 complex
See in Reactome
R-HSA-2569057
(
R-HSA-2562578
)
R-HSA-2569057
Reaction Name: RIP3 binds TRIF to mediate necroptosis
See in Reactome
R-HSA-3295579
(
R-HSA-3295583
)
R-HSA-3295579
Reaction Name: TRPs transport extracellular Ca2+ to cytosol
See in Reactome
R-HSA-3371360
(
R-HSA-140534;
R-HSA-3371378;
R-HSA-5357905;
R-HSA-75893
)
R-HSA-3371360
Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling
See in Reactome
R-HSA-3465429
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5675482
)
R-HSA-3465429
Reaction Name: FLIP(S) and procaspase-8 form heterodimer
See in Reactome
R-HSA-3465448
(
R-HSA-140534;
R-HSA-3371378
)
R-HSA-3465448
Reaction Name: Caspase-8 and FLIP(L) processing at DISC
See in Reactome
R-HSA-5213462
(
R-HSA-5213460
)
R-HSA-5213464
(
R-HSA-5213460
)
R-HSA-5213466
(
R-HSA-5213460
)
R-HSA-5218891
(
R-HSA-5213460
)
R-HSA-5218891
Reaction Name: RIPK1:RIPK3 oligomer binds MLKL
See in Reactome
R-HSA-5218905
(
R-HSA-5213460
)
R-HSA-5218905
Reaction Name: RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils
See in Reactome
R-HSA-5218906
(
R-HSA-5213460
)
R-HSA-5357757
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357757
Reaction Name: BIRC(cIAP1/2) ubiquitinates RIPK1
See in Reactome
R-HSA-5357776
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357780
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357780
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2)
See in Reactome
R-HSA-5357828
(
R-HSA-5213460;
R-HSA-5357905;
R-HSA-5675482;
R-HSA-75893
)
R-HSA-5357845
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357860
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5357904
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357904
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
See in Reactome
R-HSA-5357927
(
R-HSA-5213460
)
R-HSA-5357928
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357928
Reaction Name: CLIP3 and CYLD bind TNF signaling complex
See in Reactome
R-HSA-5620975
(
R-HSA-5213460
)
R-HSA-5634221
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5634221
Reaction Name: TRAF1 binds TRAF2 within TNFR1 signaling complex
See in Reactome
R-HSA-5675456
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5675482
)
R-HSA-5675456
Reaction Name: FLIP(L) and procaspase-8 form heterodimer
See in Reactome
R-HSA-5690159
(
R-HSA-5689880
)
R-HSA-5690159
Reaction Name: USP21 deubiquitinates RIPK1,DDX58
See in Reactome
R-HSA-5690827
(
R-HSA-5689896
)
R-HSA-5690827
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1
See in Reactome
R-HSA-5690856
(
R-HSA-5689896
)
R-HSA-5690856
Reaction Name: TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1
See in Reactome
R-HSA-5693055
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5693055
Reaction Name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes
See in Reactome
R-HSA-5693108
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5693108
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains
See in Reactome
R-HSA-5696627
(
R-HSA-5689880
)
R-HSA-5696627
Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
See in Reactome
R-HSA-75240
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-75240
Reaction Name: TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8
See in Reactome
R-HSA-83582
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-83582
Reaction Name: TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex.
See in Reactome
R-HSA-83656
(
R-HSA-75893
)
R-HSA-83656
Reaction Name: TNF:TNFR1 binds TRADD, TRAF2 and RIPK1
See in Reactome
R-HSA-9013889
(
R-HSA-9013957
)
R-HSA-9013889
Reaction Name: TLR3-induced ripoptosome assembly
See in Reactome
R-HSA-9013895
(
R-HSA-9013957
)
R-HSA-9013895
Reaction Name: Caspase-8 processing within TLR3 complex
See in Reactome
R-HSA-9013963
(
R-HSA-9013957
)
R-HSA-9013963
Reaction Name: RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis
See in Reactome
R-HSA-9014342
(
R-HSA-168927
)
R-HSA-9014342
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-9014343
(
R-HSA-168927
)
R-HSA-9014343
Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex
See in Reactome
R-HSA-933523
(
R-HSA-933543
)
R-HSA-933523
Reaction Name: Dimerzation of procaspase-8, procaspase-10
See in Reactome
R-HSA-933526
(
R-HSA-933543
)
R-HSA-933526
Reaction Name: Recruitment of caspase-8 and -10 to FADD complex
See in Reactome
R-HSA-933532
(
R-HSA-933543
)
R-HSA-933539
(
R-HSA-933543
)
R-HSA-937029
(
R-HSA-937041
)
R-HSA-937029
Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1
See in Reactome
R-HSA-9686336
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686338
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686338
Reaction Name: SARS-CoV-1 3a binds the lysosomal membrane
See in Reactome
R-HSA-9686345
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686345
Reaction Name: SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer
See in Reactome
R-HSA-9686920
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9686920
Reaction Name: PELI1 ubiquitinates RIPK3 at K363
See in Reactome
R-HSA-9686922
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9686922
Reaction Name: PELI1 binds activated RIPK1:RIPK3
See in Reactome
R-HSA-9687465
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9687625
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9687638
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9688456
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9688832
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9693978
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9693978
Reaction Name: Small molecule inhibitor binds RIPK1, RIPK3
See in Reactome
R-HSA-9697747
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-9697747
Reaction Name: Caspase-8 and FLIP(L) processing at TNFR signaling complex
See in Reactome
R-HSA-9697750
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-9697750
Reaction Name: RIPK1 is cleaved by CASP8:FLIP(L)
See in Reactome
R-HSA-9701055
(
R-HSA-3295583
)
R-HSA-9701055
Reaction Name: TRPA1 tetramer transports Ca2+ from extracellular region to cytosol
See in Reactome
R-HSA-9701141
(
R-HSA-3295583
)
R-HSA-9701141
Reaction Name: TRPV1 transports Ca2+ from extracellular region to cytosol
See in Reactome
|
MONDO:0030018 |
RIPK1 |
Q13546 |
2.7.11.1
|
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-3295583
R-HSA-168927
R-HSA-168927
Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment
See in Reactome
R-HSA-9686347
R-HSA-9686347
Reactome Name: Microbial modulation of RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-937041
R-HSA-937041
Reactome Name: IKK complex recruitment mediated by RIP1
See in Reactome
R-HSA-5213460
R-HSA-5213460
Reactome Name: RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5357905
R-HSA-5218900
R-HSA-140534
R-HSA-140534
Reactome Name: Caspase activation via Death Receptors in the presence of ligand
See in Reactome
R-HSA-2562578
R-HSA-2562578
Reactome Name: TRIF-mediated programmed cell death
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-1810476
R-HSA-1810476
Reactome Name: RIP-mediated NFkB activation via ZBP1
See in Reactome
R-HSA-69416
R-HSA-5675482
R-HSA-5675482
Reactome Name: Regulation of necroptotic cell death
See in Reactome
R-HSA-75893
R-HSA-3371378
R-HSA-5357786
R-HSA-5357786
Reactome Name: TNFR1-induced proapoptotic signaling
See in Reactome
R-HSA-9013957
R-HSA-9013957
Reactome Name: TLR3-mediated TICAM1-dependent programmed cell death
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-168256
R-HSA-382551
R-HSA-5357801
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168898
R-HSA-166166
R-HSA-1606322
R-HSA-1606322
Reactome Name: ZBP1(DAI) mediated induction of type I IFNs
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-983712
R-HSA-5357769
R-HSA-5357769
Reactome Name: Caspase activation via extrinsic apoptotic signalling pathway
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-5218859
R-HSA-73887
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
R-HSA-5688426
R-HSA-109581
R-HSA-2672351
R-HSA-162582
|
Immune System
Transport of small molecules
Programmed Cell Death
Metabolism of proteins
Signal Transduction
|
R-HSA-139952
(
R-HSA-140534
)
R-HSA-139952
Reaction Name: Caspase-8 processing in the DISC
See in Reactome
R-HSA-140978
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-140978
Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD
See in Reactome
R-HSA-141159
(
R-HSA-140534;
R-HSA-69416
)
R-HSA-141159
Reaction Name: TNF-mediated dimerization of procaspase-8
See in Reactome
R-HSA-168910
(
R-HSA-1810476
)
R-HSA-168910
Reaction Name: RIP1 facilitates IKK complex phosphorylation
See in Reactome
R-HSA-168915
(
R-HSA-937041
)
R-HSA-168915
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-168921
(
R-HSA-937041
)
R-HSA-168921
Reaction Name: TRIF:activated TLR3/TLR4 complex recruits RIP1
See in Reactome
R-HSA-168930
(
R-HSA-168927
)
R-HSA-168930
Reaction Name: Viral dsRNA:TLR3:TRIF complex recruits RIP1
See in Reactome
R-HSA-168934
(
R-HSA-933543
)
R-HSA-168934
Reaction Name: MAVS interacts with RIPK1 and FADD
See in Reactome
R-HSA-1810457
(
R-HSA-1810476
)
R-HSA-1810457
Reaction Name: ZBP1(DAI) recruits RIP1 and RIP3
See in Reactome
R-HSA-2562541
(
R-HSA-2562578
)
R-HSA-2562541
Reaction Name: TLR4-induced ripoptosome assembly
See in Reactome
R-HSA-2562564
(
R-HSA-140534;
R-HSA-2562578
)
R-HSA-2562564
Reaction Name: Caspase-8 processing within TLR4 complex
See in Reactome
R-HSA-2569057
(
R-HSA-2562578
)
R-HSA-2569057
Reaction Name: RIP3 binds TRIF to mediate necroptosis
See in Reactome
R-HSA-3295579
(
R-HSA-3295583
)
R-HSA-3295579
Reaction Name: TRPs transport extracellular Ca2+ to cytosol
See in Reactome
R-HSA-3371360
(
R-HSA-140534;
R-HSA-3371378;
R-HSA-5357905;
R-HSA-75893
)
R-HSA-3371360
Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling
See in Reactome
R-HSA-3465429
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5675482
)
R-HSA-3465429
Reaction Name: FLIP(S) and procaspase-8 form heterodimer
See in Reactome
R-HSA-3465448
(
R-HSA-140534;
R-HSA-3371378
)
R-HSA-3465448
Reaction Name: Caspase-8 and FLIP(L) processing at DISC
See in Reactome
R-HSA-5213462
(
R-HSA-5213460
)
R-HSA-5213464
(
R-HSA-5213460
)
R-HSA-5213466
(
R-HSA-5213460
)
R-HSA-5218891
(
R-HSA-5213460
)
R-HSA-5218891
Reaction Name: RIPK1:RIPK3 oligomer binds MLKL
See in Reactome
R-HSA-5218905
(
R-HSA-5213460
)
R-HSA-5218905
Reaction Name: RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils
See in Reactome
R-HSA-5218906
(
R-HSA-5213460
)
R-HSA-5357757
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357757
Reaction Name: BIRC(cIAP1/2) ubiquitinates RIPK1
See in Reactome
R-HSA-5357776
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357780
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357780
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2)
See in Reactome
R-HSA-5357828
(
R-HSA-5213460;
R-HSA-5357905;
R-HSA-5675482;
R-HSA-75893
)
R-HSA-5357845
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357860
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5357904
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357904
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
See in Reactome
R-HSA-5357927
(
R-HSA-5213460
)
R-HSA-5357928
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357928
Reaction Name: CLIP3 and CYLD bind TNF signaling complex
See in Reactome
R-HSA-5620975
(
R-HSA-5213460
)
R-HSA-5634221
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5634221
Reaction Name: TRAF1 binds TRAF2 within TNFR1 signaling complex
See in Reactome
R-HSA-5675456
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5675482
)
R-HSA-5675456
Reaction Name: FLIP(L) and procaspase-8 form heterodimer
See in Reactome
R-HSA-5690159
(
R-HSA-5689880
)
R-HSA-5690159
Reaction Name: USP21 deubiquitinates RIPK1,DDX58
See in Reactome
R-HSA-5690827
(
R-HSA-5689896
)
R-HSA-5690827
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1
See in Reactome
R-HSA-5690856
(
R-HSA-5689896
)
R-HSA-5690856
Reaction Name: TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1
See in Reactome
R-HSA-5693055
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5693055
Reaction Name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes
See in Reactome
R-HSA-5693108
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5693108
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains
See in Reactome
R-HSA-5696627
(
R-HSA-5689880
)
R-HSA-5696627
Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
See in Reactome
R-HSA-75240
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-75240
Reaction Name: TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8
See in Reactome
R-HSA-83582
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-83582
Reaction Name: TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex.
See in Reactome
R-HSA-83656
(
R-HSA-75893
)
R-HSA-83656
Reaction Name: TNF:TNFR1 binds TRADD, TRAF2 and RIPK1
See in Reactome
R-HSA-9013889
(
R-HSA-9013957
)
R-HSA-9013889
Reaction Name: TLR3-induced ripoptosome assembly
See in Reactome
R-HSA-9013895
(
R-HSA-9013957
)
R-HSA-9013895
Reaction Name: Caspase-8 processing within TLR3 complex
See in Reactome
R-HSA-9013963
(
R-HSA-9013957
)
R-HSA-9013963
Reaction Name: RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis
See in Reactome
R-HSA-9014342
(
R-HSA-168927
)
R-HSA-9014342
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-9014343
(
R-HSA-168927
)
R-HSA-9014343
Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex
See in Reactome
R-HSA-933523
(
R-HSA-933543
)
R-HSA-933523
Reaction Name: Dimerzation of procaspase-8, procaspase-10
See in Reactome
R-HSA-933526
(
R-HSA-933543
)
R-HSA-933526
Reaction Name: Recruitment of caspase-8 and -10 to FADD complex
See in Reactome
R-HSA-933532
(
R-HSA-933543
)
R-HSA-933539
(
R-HSA-933543
)
R-HSA-937029
(
R-HSA-937041
)
R-HSA-937029
Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1
See in Reactome
R-HSA-9686336
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686338
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686338
Reaction Name: SARS-CoV-1 3a binds the lysosomal membrane
See in Reactome
R-HSA-9686345
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686345
Reaction Name: SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer
See in Reactome
R-HSA-9686920
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9686920
Reaction Name: PELI1 ubiquitinates RIPK3 at K363
See in Reactome
R-HSA-9686922
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9686922
Reaction Name: PELI1 binds activated RIPK1:RIPK3
See in Reactome
R-HSA-9687465
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9687625
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9687638
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9688456
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9688832
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9693978
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9693978
Reaction Name: Small molecule inhibitor binds RIPK1, RIPK3
See in Reactome
R-HSA-9697747
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-9697747
Reaction Name: Caspase-8 and FLIP(L) processing at TNFR signaling complex
See in Reactome
R-HSA-9697750
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-9697750
Reaction Name: RIPK1 is cleaved by CASP8:FLIP(L)
See in Reactome
R-HSA-9701055
(
R-HSA-3295583
)
R-HSA-9701055
Reaction Name: TRPA1 tetramer transports Ca2+ from extracellular region to cytosol
See in Reactome
R-HSA-9701141
(
R-HSA-3295583
)
R-HSA-9701141
Reaction Name: TRPV1 transports Ca2+ from extracellular region to cytosol
See in Reactome
|
MONDO:0030872 |
CYLD |
Q9NQC7 |
3.4.19.12
|
R-HSA-5357786
R-HSA-5357786
Reactome Name: TNFR1-induced proapoptotic signaling
See in Reactome
R-HSA-168638
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-936440
R-HSA-936440
Reactome Name: Negative regulators of DDX58/IFIH1 signaling
See in Reactome
R-HSA-5357905
|
R-HSA-5688426
R-HSA-168256
R-HSA-392499
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-73887
R-HSA-75893
R-HSA-168249
R-HSA-162582
|
Immune System
Metabolism of proteins
Signal Transduction
|
R-HSA-140978
(
R-HSA-5357786
)
R-HSA-140978
Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD
See in Reactome
R-HSA-5357776
(
R-HSA-5357956
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357831
(
R-HSA-5357905
)
R-HSA-5357845
(
R-HSA-5357905
)
R-HSA-5357860
(
R-HSA-5357956
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5357928
(
R-HSA-5357905
)
R-HSA-5357928
Reaction Name: CLIP3 and CYLD bind TNF signaling complex
See in Reactome
R-HSA-5696627
(
R-HSA-5689880
)
R-HSA-5696627
Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
See in Reactome
R-HSA-741411
(
R-HSA-168638
)
R-HSA-936390
(
R-HSA-5689880;
R-HSA-936440
)
R-HSA-936390
Reaction Name: CYLD mediated deubiquitination of DDX58 (RIG-I)
See in Reactome
|
MONDO:0033968 |
RIPK1 |
Q13546 |
2.7.11.1
|
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-3295583
R-HSA-168927
R-HSA-168927
Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment
See in Reactome
R-HSA-9686347
R-HSA-9686347
Reactome Name: Microbial modulation of RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-937041
R-HSA-937041
Reactome Name: IKK complex recruitment mediated by RIP1
See in Reactome
R-HSA-5213460
R-HSA-5213460
Reactome Name: RIPK1-mediated regulated necrosis
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-5357905
R-HSA-5218900
R-HSA-140534
R-HSA-140534
Reactome Name: Caspase activation via Death Receptors in the presence of ligand
See in Reactome
R-HSA-2562578
R-HSA-2562578
Reactome Name: TRIF-mediated programmed cell death
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-1810476
R-HSA-1810476
Reactome Name: RIP-mediated NFkB activation via ZBP1
See in Reactome
R-HSA-69416
R-HSA-5675482
R-HSA-5675482
Reactome Name: Regulation of necroptotic cell death
See in Reactome
R-HSA-75893
R-HSA-3371378
R-HSA-5357786
R-HSA-5357786
Reactome Name: TNFR1-induced proapoptotic signaling
See in Reactome
R-HSA-9013957
R-HSA-9013957
Reactome Name: TLR3-mediated TICAM1-dependent programmed cell death
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-168256
R-HSA-382551
R-HSA-5357801
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168898
R-HSA-166166
R-HSA-1606322
R-HSA-1606322
Reactome Name: ZBP1(DAI) mediated induction of type I IFNs
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-983712
R-HSA-5357769
R-HSA-5357769
Reactome Name: Caspase activation via extrinsic apoptotic signalling pathway
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-5218859
R-HSA-73887
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
R-HSA-5688426
R-HSA-109581
R-HSA-2672351
R-HSA-162582
|
Immune System
Transport of small molecules
Programmed Cell Death
Metabolism of proteins
Signal Transduction
|
R-HSA-139952
(
R-HSA-140534
)
R-HSA-139952
Reaction Name: Caspase-8 processing in the DISC
See in Reactome
R-HSA-140978
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-140978
Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD
See in Reactome
R-HSA-141159
(
R-HSA-140534;
R-HSA-69416
)
R-HSA-141159
Reaction Name: TNF-mediated dimerization of procaspase-8
See in Reactome
R-HSA-168910
(
R-HSA-1810476
)
R-HSA-168910
Reaction Name: RIP1 facilitates IKK complex phosphorylation
See in Reactome
R-HSA-168915
(
R-HSA-937041
)
R-HSA-168915
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-168921
(
R-HSA-937041
)
R-HSA-168921
Reaction Name: TRIF:activated TLR3/TLR4 complex recruits RIP1
See in Reactome
R-HSA-168930
(
R-HSA-168927
)
R-HSA-168930
Reaction Name: Viral dsRNA:TLR3:TRIF complex recruits RIP1
See in Reactome
R-HSA-168934
(
R-HSA-933543
)
R-HSA-168934
Reaction Name: MAVS interacts with RIPK1 and FADD
See in Reactome
R-HSA-1810457
(
R-HSA-1810476
)
R-HSA-1810457
Reaction Name: ZBP1(DAI) recruits RIP1 and RIP3
See in Reactome
R-HSA-2562541
(
R-HSA-2562578
)
R-HSA-2562541
Reaction Name: TLR4-induced ripoptosome assembly
See in Reactome
R-HSA-2562564
(
R-HSA-140534;
R-HSA-2562578
)
R-HSA-2562564
Reaction Name: Caspase-8 processing within TLR4 complex
See in Reactome
R-HSA-2569057
(
R-HSA-2562578
)
R-HSA-2569057
Reaction Name: RIP3 binds TRIF to mediate necroptosis
See in Reactome
R-HSA-3295579
(
R-HSA-3295583
)
R-HSA-3295579
Reaction Name: TRPs transport extracellular Ca2+ to cytosol
See in Reactome
R-HSA-3371360
(
R-HSA-140534;
R-HSA-3371378;
R-HSA-5357905;
R-HSA-75893
)
R-HSA-3371360
Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling
See in Reactome
R-HSA-3465429
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5675482
)
R-HSA-3465429
Reaction Name: FLIP(S) and procaspase-8 form heterodimer
See in Reactome
R-HSA-3465448
(
R-HSA-140534;
R-HSA-3371378
)
R-HSA-3465448
Reaction Name: Caspase-8 and FLIP(L) processing at DISC
See in Reactome
R-HSA-5213462
(
R-HSA-5213460
)
R-HSA-5213464
(
R-HSA-5213460
)
R-HSA-5213466
(
R-HSA-5213460
)
R-HSA-5218891
(
R-HSA-5213460
)
R-HSA-5218891
Reaction Name: RIPK1:RIPK3 oligomer binds MLKL
See in Reactome
R-HSA-5218905
(
R-HSA-5213460
)
R-HSA-5218905
Reaction Name: RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils
See in Reactome
R-HSA-5218906
(
R-HSA-5213460
)
R-HSA-5357757
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357757
Reaction Name: BIRC(cIAP1/2) ubiquitinates RIPK1
See in Reactome
R-HSA-5357776
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357780
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357780
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2)
See in Reactome
R-HSA-5357828
(
R-HSA-5213460;
R-HSA-5357905;
R-HSA-5675482;
R-HSA-75893
)
R-HSA-5357845
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357860
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5357904
(
R-HSA-5357956;
R-HSA-75893
)
R-HSA-5357904
Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC
See in Reactome
R-HSA-5357927
(
R-HSA-5213460
)
R-HSA-5357928
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5357928
Reaction Name: CLIP3 and CYLD bind TNF signaling complex
See in Reactome
R-HSA-5620975
(
R-HSA-5213460
)
R-HSA-5634221
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5634221
Reaction Name: TRAF1 binds TRAF2 within TNFR1 signaling complex
See in Reactome
R-HSA-5675456
(
R-HSA-5213460;
R-HSA-5218900;
R-HSA-5675482
)
R-HSA-5675456
Reaction Name: FLIP(L) and procaspase-8 form heterodimer
See in Reactome
R-HSA-5690159
(
R-HSA-5689880
)
R-HSA-5690159
Reaction Name: USP21 deubiquitinates RIPK1,DDX58
See in Reactome
R-HSA-5690827
(
R-HSA-5689896
)
R-HSA-5690827
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1
See in Reactome
R-HSA-5690856
(
R-HSA-5689896
)
R-HSA-5690856
Reaction Name: TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1
See in Reactome
R-HSA-5693055
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5693055
Reaction Name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes
See in Reactome
R-HSA-5693108
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-5693108
Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains
See in Reactome
R-HSA-5696627
(
R-HSA-5689880
)
R-HSA-5696627
Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
See in Reactome
R-HSA-75240
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-75240
Reaction Name: TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8
See in Reactome
R-HSA-83582
(
R-HSA-5357786;
R-HSA-75893
)
R-HSA-83582
Reaction Name: TRADD:TRAF2:RIP1 complex dissociates from the TNF-alpha:TNF-R1 complex.
See in Reactome
R-HSA-83656
(
R-HSA-75893
)
R-HSA-83656
Reaction Name: TNF:TNFR1 binds TRADD, TRAF2 and RIPK1
See in Reactome
R-HSA-9013889
(
R-HSA-9013957
)
R-HSA-9013889
Reaction Name: TLR3-induced ripoptosome assembly
See in Reactome
R-HSA-9013895
(
R-HSA-9013957
)
R-HSA-9013895
Reaction Name: Caspase-8 processing within TLR3 complex
See in Reactome
R-HSA-9013963
(
R-HSA-9013957
)
R-HSA-9013963
Reaction Name: RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis
See in Reactome
R-HSA-9014342
(
R-HSA-168927
)
R-HSA-9014342
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-9014343
(
R-HSA-168927
)
R-HSA-9014343
Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex
See in Reactome
R-HSA-933523
(
R-HSA-933543
)
R-HSA-933523
Reaction Name: Dimerzation of procaspase-8, procaspase-10
See in Reactome
R-HSA-933526
(
R-HSA-933543
)
R-HSA-933526
Reaction Name: Recruitment of caspase-8 and -10 to FADD complex
See in Reactome
R-HSA-933532
(
R-HSA-933543
)
R-HSA-933539
(
R-HSA-933543
)
R-HSA-937029
(
R-HSA-937041
)
R-HSA-937029
Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1
See in Reactome
R-HSA-9686336
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686338
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686338
Reaction Name: SARS-CoV-1 3a binds the lysosomal membrane
See in Reactome
R-HSA-9686345
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9686345
Reaction Name: SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer
See in Reactome
R-HSA-9686920
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9686920
Reaction Name: PELI1 ubiquitinates RIPK3 at K363
See in Reactome
R-HSA-9686922
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9686922
Reaction Name: PELI1 binds activated RIPK1:RIPK3
See in Reactome
R-HSA-9687465
(
R-HSA-5213460;
R-HSA-9686347
)
R-HSA-9687625
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9687638
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9688456
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9688832
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9693978
(
R-HSA-5213460;
R-HSA-5675482
)
R-HSA-9693978
Reaction Name: Small molecule inhibitor binds RIPK1, RIPK3
See in Reactome
R-HSA-9697747
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-9697747
Reaction Name: Caspase-8 and FLIP(L) processing at TNFR signaling complex
See in Reactome
R-HSA-9697750
(
R-HSA-5357905;
R-HSA-75893
)
R-HSA-9697750
Reaction Name: RIPK1 is cleaved by CASP8:FLIP(L)
See in Reactome
R-HSA-9701055
(
R-HSA-3295583
)
R-HSA-9701055
Reaction Name: TRPA1 tetramer transports Ca2+ from extracellular region to cytosol
See in Reactome
R-HSA-9701141
(
R-HSA-3295583
)
R-HSA-9701141
Reaction Name: TRPV1 transports Ca2+ from extracellular region to cytosol
See in Reactome
|
MONDO:0042977 |
CYLD |
Q9NQC7 |
3.4.19.12
|
R-HSA-5357786
R-HSA-5357786
Reactome Name: TNFR1-induced proapoptotic signaling
See in Reactome
R-HSA-168638
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-936440
R-HSA-936440
Reactome Name: Negative regulators of DDX58/IFIH1 signaling
See in Reactome
R-HSA-5357905
|
R-HSA-5688426
R-HSA-168256
R-HSA-392499
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-73887
R-HSA-75893
R-HSA-168249
R-HSA-162582
|
Immune System
Metabolism of proteins
Signal Transduction
|
R-HSA-140978
(
R-HSA-5357786
)
R-HSA-140978
Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD
See in Reactome
R-HSA-5357776
(
R-HSA-5357956
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357831
(
R-HSA-5357905
)
R-HSA-5357845
(
R-HSA-5357905
)
R-HSA-5357860
(
R-HSA-5357956
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5357928
(
R-HSA-5357905
)
R-HSA-5357928
Reaction Name: CLIP3 and CYLD bind TNF signaling complex
See in Reactome
R-HSA-5696627
(
R-HSA-5689880
)
R-HSA-5696627
Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
See in Reactome
R-HSA-741411
(
R-HSA-168638
)
R-HSA-936390
(
R-HSA-5689880;
R-HSA-936440
)
R-HSA-936390
Reaction Name: CYLD mediated deubiquitination of DDX58 (RIG-I)
See in Reactome
|