DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-499943)

Number of enzymes:	7
Number of disease:	12
Number of reactomes:	4
Number of reactions:	16

Search results (Reactome ID: R-HSA-499943)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009973	AK2	P54819	2.7.4.3	R-HSA-499943 R-HSA-499943 Reactome Name: Interconversion of nucleotide di- and triphosphates See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-15869 R-HSA-15869 Reactome Name: Metabolism of nucleotides See in Reactome	Metabolism	R-HSA-110144 ( R-HSA-499943 ) R-HSA-110144 Reaction Name: ADP + ADP <=> AMP + ATP [AK2] See in Reactome R-HSA-110145 ( R-HSA-499943 ) R-HSA-110145 Reaction Name: AMP + ATP <=> ADP + ADP [AK2] See in Reactome
MONDO:0010787	RRM2B	Q7LG56	1.17.4.1	R-HSA-499943 R-HSA-499943 Reactome Name: Interconversion of nucleotide di- and triphosphates See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-15869 R-HSA-15869 Reactome Name: Metabolism of nucleotides See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism	R-HSA-111804 ( R-HSA-499943 ) R-HSA-111804 Reaction Name: RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) See in Reactome R-HSA-5632892 ( R-HSA-5628897 ) R-HSA-5632892 Reaction Name: TP53 stimulates transcription of RRM2B gene See in Reactome R-HSA-8866405 ( R-HSA-499943 ) R-HSA-8866405 Reaction Name: RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) See in Reactome
MONDO:0012792	RRM2B	Q7LG56	1.17.4.1	R-HSA-499943 R-HSA-499943 Reactome Name: Interconversion of nucleotide di- and triphosphates See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-15869 R-HSA-15869 Reactome Name: Metabolism of nucleotides See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism	R-HSA-111804 ( R-HSA-499943 ) R-HSA-111804 Reaction Name: RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) See in Reactome R-HSA-5632892 ( R-HSA-5628897 ) R-HSA-5632892 Reaction Name: TP53 stimulates transcription of RRM2B gene See in Reactome R-HSA-8866405 ( R-HSA-499943 ) R-HSA-8866405 Reaction Name: RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) See in Reactome
MONDO:0012967	AK1	P00568	2.7.4.6 2.7.4.3	R-HSA-499943 R-HSA-499943 Reactome Name: Interconversion of nucleotide di- and triphosphates See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-15869 R-HSA-15869 Reactome Name: Metabolism of nucleotides See in Reactome	Metabolism	R-HSA-110141 ( R-HSA-499943 ) R-HSA-110141 Reaction Name: (d)ADP + ADP <=> (d)AMP + ATP (AK1) See in Reactome R-HSA-73548 ( R-HSA-499943 ) R-HSA-73548 Reaction Name: (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) See in Reactome R-HSA-74220 ( R-HSA-499943 ) R-HSA-74220 Reaction Name: (d)AMP + ATP <=> (d)ADP + ADP (AK1) See in Reactome R-HSA-75125 ( R-HSA-499943 ) R-HSA-75125 Reaction Name: (d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) See in Reactome
MONDO:0013117	RRM2B	Q7LG56	1.17.4.1	R-HSA-499943 R-HSA-499943 Reactome Name: Interconversion of nucleotide di- and triphosphates See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-15869 R-HSA-15869 Reactome Name: Metabolism of nucleotides See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism	R-HSA-111804 ( R-HSA-499943 ) R-HSA-111804 Reaction Name: RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) See in Reactome R-HSA-5632892 ( R-HSA-5628897 ) R-HSA-5632892 Reaction Name: TP53 stimulates transcription of RRM2B gene See in Reactome R-HSA-8866405 ( R-HSA-499943 ) R-HSA-8866405 Reaction Name: RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) See in Reactome
MONDO:0014391	CTPS1	P17812	6.3.4.2	R-HSA-499943 R-HSA-499943 Reactome Name: Interconversion of nucleotide di- and triphosphates See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-15869 R-HSA-15869 Reactome Name: Metabolism of nucleotides See in Reactome	Metabolism	R-HSA-73647 ( R-HSA-499943 ) R-HSA-73647 Reaction Name: UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] See in Reactome
MONDO:0017173	AK7	Q96M32	2.7.4.6 2.7.4.3	R-HSA-499943 R-HSA-499943 Reactome Name: Interconversion of nucleotide di- and triphosphates See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-15869 R-HSA-15869 Reactome Name: Metabolism of nucleotides See in Reactome	Metabolism	R-HSA-110137 ( R-HSA-499943 ) R-HSA-110137 Reaction Name: (d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP See in Reactome R-HSA-110138 ( R-HSA-499943 ) R-HSA-110138 Reaction Name: AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs See in Reactome
MONDO:0017575	RRM2B	Q7LG56	1.17.4.1	R-HSA-499943 R-HSA-499943 Reactome Name: Interconversion of nucleotide di- and triphosphates See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-15869 R-HSA-15869 Reactome Name: Metabolism of nucleotides See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism	R-HSA-111804 ( R-HSA-499943 ) R-HSA-111804 Reaction Name: RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) See in Reactome R-HSA-5632892 ( R-HSA-5628897 ) R-HSA-5632892 Reaction Name: TP53 stimulates transcription of RRM2B gene See in Reactome R-HSA-8866405 ( R-HSA-499943 ) R-HSA-8866405 Reaction Name: RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) See in Reactome
MONDO:0018002	RRM2B	Q7LG56	1.17.4.1	R-HSA-499943 R-HSA-499943 Reactome Name: Interconversion of nucleotide di- and triphosphates See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-15869 R-HSA-15869 Reactome Name: Metabolism of nucleotides See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism	R-HSA-111804 ( R-HSA-499943 ) R-HSA-111804 Reaction Name: RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) See in Reactome R-HSA-5632892 ( R-HSA-5628897 ) R-HSA-5632892 Reaction Name: TP53 stimulates transcription of RRM2B gene See in Reactome R-HSA-8866405 ( R-HSA-499943 ) R-HSA-8866405 Reaction Name: RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) See in Reactome
MONDO:0019531	GSR	P00390	1.8.1.7	R-HSA-499943 R-HSA-499943 Reactome Name: Interconversion of nucleotide di- and triphosphates See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-2408550 R-HSA-2408550 Reactome Name: Metabolism of ingested H2SeO4 and H2SeO3 into H2Se See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-15869 R-HSA-15869 Reactome Name: Metabolism of nucleotides See in Reactome R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Cellular responses to stimuli Metabolism Gene expression (Transcription)	R-HSA-2408542 ( R-HSA-2408550 ) R-HSA-2408542 Reaction Name: GSSeSG is reduced to GSSeH and GSH by GSR See in Reactome R-HSA-3323079 ( R-HSA-3299685 ) R-HSA-3323079 Reaction Name: GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ See in Reactome R-HSA-71682 ( R-HSA-3299685; R-HSA-499943; R-HSA-5628897 ) R-HSA-71682 Reaction Name: glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ See in Reactome R-HSA-9761843 () R-HSA-9761843 Reaction Name: NFE2L2-dependent GSR gene expression See in Reactome
MONDO:0020344	AK9	Q5TCS8	2.7.4.4 2.7.4.6	R-HSA-499943 R-HSA-499943 Reactome Name: Interconversion of nucleotide di- and triphosphates See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-15869 R-HSA-15869 Reactome Name: Metabolism of nucleotides See in Reactome	Metabolism	R-HSA-110137 ( R-HSA-499943 ) R-HSA-110137 Reaction Name: (d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP See in Reactome R-HSA-110138 ( R-HSA-499943 ) R-HSA-110138 Reaction Name: AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs See in Reactome
MONDO:0054731	AK7	Q96M32	2.7.4.6 2.7.4.3	R-HSA-499943 R-HSA-499943 Reactome Name: Interconversion of nucleotide di- and triphosphates See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-15869 R-HSA-15869 Reactome Name: Metabolism of nucleotides See in Reactome	Metabolism	R-HSA-110137 ( R-HSA-499943 ) R-HSA-110137 Reaction Name: (d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP See in Reactome R-HSA-110138 ( R-HSA-499943 ) R-HSA-110138 Reaction Name: AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs See in Reactome