DAR - Bologna Biocomputing Group

Search results (Reactome ID: R-HSA-445144)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0002529	RAC1	P63000	3.6.5.2	R-HSA-376172 R-HSA-376172 Reactome Name: DSCAM interactions See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-9619229 R-HSA-9619229 Reactome Name: Activation of RAC1 downstream of NMDARs See in Reactome R-HSA-428540 R-HSA-428540 Reactome Name: Activation of RAC1 See in Reactome R-HSA-428543 R-HSA-428543 Reactome Name: Inactivation of CDC42 and RAC1 See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-399954 R-HSA-399954 Reactome Name: Sema3A PAK dependent Axon repulsion See in Reactome R-HSA-9032845 R-HSA-9032845 Reactome Name: Activated NTRK2 signals through CDK5 See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-193648 R-HSA-193648 Reactome Name: NRAGE signals death through JNK See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-9032759 R-HSA-9032759 Reactome Name: NTRK2 activates RAC1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-389359 R-HSA-389359 Reactome Name: CD28 dependent Vav1 pathway See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome R-HSA-399955 R-HSA-399955 Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion See in Reactome R-HSA-5626467 R-HSA-5626467 Reactome Name: RHO GTPases activate IQGAPs See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Developmental Biology Neuronal System Vesicle-mediated transport Hemostasis Signal Transduction	R-HSA-1011598 ( R-HSA-983231 ) R-HSA-1011598 Reaction Name: DOCKs bind to RhoGEFs See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1433415 ( R-HSA-1433557 ) R-HSA-1433415 Reaction Name: Activation of RAC1 See in Reactome R-HSA-2029451 ( R-HSA-2029482 ) R-HSA-2029451 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2029454 ( R-HSA-2029482 ) R-HSA-2029454 Reaction Name: Autophosphorylation of PAK1 See in Reactome R-HSA-2029456 ( R-HSA-2029482; R-HSA-5627123 ) R-HSA-2029456 Reaction Name: RAC1 and CDC42 activate PAK1 See in Reactome R-HSA-2029465 ( R-HSA-2029482; R-HSA-4420097; R-HSA-5663213 ) R-HSA-2029465 Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) See in Reactome R-HSA-2029466 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029466 Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin See in Reactome R-HSA-2029467 ( R-HSA-2029482 ) R-HSA-2029467 Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO See in Reactome R-HSA-2029469 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029469 Reaction Name: p-ERK phosphorylates WAVEs and ABI See in Reactome R-HSA-205039 ( R-HSA-193648 ) R-HSA-205039 Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor See in Reactome R-HSA-205136 ( R-HSA-193648 ) R-HSA-205136 Reaction Name: GTP-bound RAC contributes to JNK activation See in Reactome R-HSA-2130194 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2130194 Reaction Name: ABL phosphorylates WAVEs See in Reactome R-HSA-2197690 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2197690 Reaction Name: Detachment of WASP/WAVE See in Reactome R-HSA-2316352 ( R-HSA-1445148 ) R-HSA-2316352 Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424476 ( R-HSA-2424491 ) R-HSA-2424476 Reaction Name: Activation of RAC1 by VAV2/3 See in Reactome R-HSA-2730840 ( R-HSA-2871796 ) R-HSA-2730840 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2730856 ( R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730889 ( R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-376123 ( R-HSA-376172 ) R-HSA-376123 Reaction Name: DSCAM associates with Rac1-GTP:pPAK1 See in Reactome R-HSA-3858475 ( R-HSA-4086400 ) R-HSA-3858475 Reaction Name: ppDVL recruits RAC See in Reactome R-HSA-389348 ( R-HSA-389359 ) R-HSA-389348 Reaction Name: Activation of Rac1 by pVav1 See in Reactome R-HSA-389788 ( R-HSA-389359; R-HSA-5687128 ) R-HSA-389788 Reaction Name: Activation of PAKs by RAC1 and CDC42 See in Reactome R-HSA-3928612 ( R-HSA-3928662 ) R-HSA-3928612 Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928619 ( R-HSA-3928662 ) R-HSA-3928619 Reaction Name: PAK1 binds RAC1:GTP See in Reactome R-HSA-3928620 ( R-HSA-3928662 ) R-HSA-3928620 Reaction Name: PAK1 autophosphorylates See in Reactome R-HSA-3928625 ( R-HSA-3928664 ) R-HSA-3928625 Reaction Name: PAKs autophosphorylate See in Reactome R-HSA-3928628 ( R-HSA-3928665 ) R-HSA-3928628 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928633 ( R-HSA-3928664 ) R-HSA-3928633 Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it See in Reactome R-HSA-3928640 ( R-HSA-3928664 ) R-HSA-3928640 Reaction Name: PAKs phosphorylate MLC See in Reactome R-HSA-3928641 ( R-HSA-3928664 ) R-HSA-3928641 Reaction Name: PAK binds RAC and bPIX See in Reactome R-HSA-3928642 ( R-HSA-3928665 ) R-HSA-3928642 Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-399928 ( R-HSA-399955 ) R-HSA-399928 Reaction Name: Recruitment of Rnd1 to Plexin A See in Reactome R-HSA-399930 ( R-HSA-399954 ) R-HSA-399930 Reaction Name: Activation of PAK by Rac1 See in Reactome R-HSA-399935 ( R-HSA-399955 ) R-HSA-399935 Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity See in Reactome R-HSA-399938 ( R-HSA-399955 ) R-HSA-399938 Reaction Name: Activation of Rac1 by FARP2 See in Reactome R-HSA-399939 ( R-HSA-399954 ) R-HSA-399939 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-399941 ( R-HSA-399955 ) R-HSA-399941 Reaction Name: Rac1 binds PlexinA See in Reactome R-HSA-399952 ( R-HSA-399954 ) R-HSA-399952 Reaction Name: Phosphorylation of LIMK-1 by PAK See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-4093336 ( R-HSA-3928662 ) R-HSA-4093336 Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-418856 ( R-HSA-418885 ) R-HSA-418856 Reaction Name: Activation of Rac1 See in Reactome R-HSA-418865 ( R-HSA-418885 ) R-HSA-418865 Reaction Name: Recruitment of ABLIM to the plasma membrane See in Reactome R-HSA-428522 ( R-HSA-428543 ) R-HSA-428522 Reaction Name: Inactivation of RAC1 See in Reactome R-HSA-428535 ( R-HSA-428540 ) R-HSA-428535 Reaction Name: Activation of RAC1 by SOS See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442592 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-442592 Reaction Name: WASPs or WAVEs activate the ARP2/3 complex See in Reactome R-HSA-445064 ( R-HSA-445144 ) R-HSA-445064 Reaction Name: Activation of Rac1 by VAV2 See in Reactome R-HSA-445072 ( R-HSA-445144 ) R-HSA-445072 Reaction Name: Interaction of PAK1 with Rac1-GTP See in Reactome R-HSA-451347 ( R-HSA-376172 ) R-HSA-451347 Reaction Name: Activation of JNK by DSCAM See in Reactome R-HSA-451366 ( R-HSA-376172 ) R-HSA-451366 Reaction Name: Activation of p38MAPK by DSCAM See in Reactome R-HSA-5218827 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218827 Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1 See in Reactome R-HSA-5218839 ( R-HSA-4420097 ) R-HSA-5218839 Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1 See in Reactome R-HSA-5218841 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218841 Reaction Name: NADPH oxidase 2 generates superoxide from oxygen See in Reactome R-HSA-5218850 ( R-HSA-4420097 ) R-HSA-5218850 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-5357445 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357445 Reaction Name: PAK1-3 dimer disassociates See in Reactome R-HSA-5357472 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357472 Reaction Name: PAK1-3 autophosphorylates See in Reactome R-HSA-5357483 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357483 Reaction Name: RAC1 binds PAK1-3 See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5626469 ( R-HSA-5626467 ) R-HSA-5626469 Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs See in Reactome R-HSA-5626507 ( R-HSA-5626467 ) R-HSA-5626507 Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin See in Reactome R-HSA-5626549 ( R-HSA-5626467 ) R-HSA-5626549 Reaction Name: IQGAPs bind CALM1 See in Reactome R-HSA-5627775 ( R-HSA-5627123; R-HSA-5687128 ) R-HSA-5627775 Reaction Name: Autophosphorylation of PAK1,2,3 See in Reactome R-HSA-5663232 ( R-HSA-5663220 ) R-HSA-5663232 Reaction Name: FMNL1 binds RAC1:GTP See in Reactome R-HSA-5665659 ( R-HSA-5663220 ) R-HSA-5665659 Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin See in Reactome R-HSA-5665802 ( R-HSA-5663220 ) R-HSA-5665802 Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin See in Reactome R-HSA-5665809 ( R-HSA-5663220 ) R-HSA-5665809 Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments See in Reactome R-HSA-5668714 ( R-HSA-5668599 ) R-HSA-5668714 Reaction Name: RAC1:GTP binds NOX1 complex See in Reactome R-HSA-5668718 ( R-HSA-5668599 ) R-HSA-5668718 Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668731 ( R-HSA-5668599 ) R-HSA-5668731 Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668735 ( R-HSA-5668599 ) R-HSA-5668735 Reaction Name: RAC1:GTP binds NOX3 complex See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5672304 ( R-HSA-5626467 ) R-HSA-5672304 Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 See in Reactome R-HSA-5672329 ( R-HSA-5626467 ) R-HSA-5672329 Reaction Name: IQGAP1 binds CLIP1 and microtubules See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8848618 ( R-HSA-8849471 ) R-HSA-8848618 Reaction Name: Activation of RAC1 by the PXN:CRK complex See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8951586 ( R-HSA-4420097 ) R-HSA-8951586 Reaction Name: p-VAV family:PIP3 binds RAC1:GDP See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981926 ( R-HSA-5627123 ) R-HSA-8981926 Reaction Name: RAC1 and CDC42 activate PAK3 See in Reactome R-HSA-8981931 ( R-HSA-5627123 ) R-HSA-8981931 Reaction Name: RAC1 and CDC42 activate PAK2 See in Reactome R-HSA-9013143 ( R-HSA-9013149 ) R-HSA-9013143 Reaction Name: RAC1 GEFs activate RAC1 See in Reactome R-HSA-9013144 ( R-HSA-9013149 ) R-HSA-9013144 Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9013147 ( R-HSA-9013149 ) R-HSA-9013147 Reaction Name: RAC1 GDIs block activation of RAC1 See in Reactome R-HSA-9032798 ( R-HSA-9032759 ) R-HSA-9032798 Reaction Name: DOCK3 activates RAC1 See in Reactome R-HSA-9033292 ( R-HSA-9032845 ) R-HSA-9033292 Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1 See in Reactome R-HSA-9619803 ( R-HSA-9619229 ) R-HSA-9619803 Reaction Name: p-S516-ARHGEF7 activates RAC1 See in Reactome R-HSA-9691168 ( R-HSA-9013149 ) R-HSA-9691168 Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane See in Reactome R-HSA-9691174 ( R-HSA-9013149 ) R-HSA-9691174 Reaction Name: RAC1 binds effectors at the ER membrane See in Reactome
MONDO:0002911	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-8939211; R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-8939211; R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-8939211; R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0005012	RAC1	P63000	3.6.5.2	R-HSA-376172 R-HSA-376172 Reactome Name: DSCAM interactions See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-9619229 R-HSA-9619229 Reactome Name: Activation of RAC1 downstream of NMDARs See in Reactome R-HSA-428540 R-HSA-428540 Reactome Name: Activation of RAC1 See in Reactome R-HSA-428543 R-HSA-428543 Reactome Name: Inactivation of CDC42 and RAC1 See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-399954 R-HSA-399954 Reactome Name: Sema3A PAK dependent Axon repulsion See in Reactome R-HSA-9032845 R-HSA-9032845 Reactome Name: Activated NTRK2 signals through CDK5 See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-193648 R-HSA-193648 Reactome Name: NRAGE signals death through JNK See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-9032759 R-HSA-9032759 Reactome Name: NTRK2 activates RAC1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-389359 R-HSA-389359 Reactome Name: CD28 dependent Vav1 pathway See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome R-HSA-399955 R-HSA-399955 Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion See in Reactome R-HSA-5626467 R-HSA-5626467 Reactome Name: RHO GTPases activate IQGAPs See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Developmental Biology Neuronal System Vesicle-mediated transport Hemostasis Signal Transduction	R-HSA-1011598 ( R-HSA-983231 ) R-HSA-1011598 Reaction Name: DOCKs bind to RhoGEFs See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1433415 ( R-HSA-1433557 ) R-HSA-1433415 Reaction Name: Activation of RAC1 See in Reactome R-HSA-2029451 ( R-HSA-2029482 ) R-HSA-2029451 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2029454 ( R-HSA-2029482 ) R-HSA-2029454 Reaction Name: Autophosphorylation of PAK1 See in Reactome R-HSA-2029456 ( R-HSA-2029482; R-HSA-5627123 ) R-HSA-2029456 Reaction Name: RAC1 and CDC42 activate PAK1 See in Reactome R-HSA-2029465 ( R-HSA-2029482; R-HSA-4420097; R-HSA-5663213 ) R-HSA-2029465 Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) See in Reactome R-HSA-2029466 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029466 Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin See in Reactome R-HSA-2029467 ( R-HSA-2029482 ) R-HSA-2029467 Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO See in Reactome R-HSA-2029469 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029469 Reaction Name: p-ERK phosphorylates WAVEs and ABI See in Reactome R-HSA-205039 ( R-HSA-193648 ) R-HSA-205039 Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor See in Reactome R-HSA-205136 ( R-HSA-193648 ) R-HSA-205136 Reaction Name: GTP-bound RAC contributes to JNK activation See in Reactome R-HSA-2130194 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2130194 Reaction Name: ABL phosphorylates WAVEs See in Reactome R-HSA-2197690 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2197690 Reaction Name: Detachment of WASP/WAVE See in Reactome R-HSA-2316352 ( R-HSA-1445148 ) R-HSA-2316352 Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424476 ( R-HSA-2424491 ) R-HSA-2424476 Reaction Name: Activation of RAC1 by VAV2/3 See in Reactome R-HSA-2730840 ( R-HSA-2871796 ) R-HSA-2730840 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2730856 ( R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730889 ( R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-376123 ( R-HSA-376172 ) R-HSA-376123 Reaction Name: DSCAM associates with Rac1-GTP:pPAK1 See in Reactome R-HSA-3858475 ( R-HSA-4086400 ) R-HSA-3858475 Reaction Name: ppDVL recruits RAC See in Reactome R-HSA-389348 ( R-HSA-389359 ) R-HSA-389348 Reaction Name: Activation of Rac1 by pVav1 See in Reactome R-HSA-389788 ( R-HSA-389359; R-HSA-5687128 ) R-HSA-389788 Reaction Name: Activation of PAKs by RAC1 and CDC42 See in Reactome R-HSA-3928612 ( R-HSA-3928662 ) R-HSA-3928612 Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928619 ( R-HSA-3928662 ) R-HSA-3928619 Reaction Name: PAK1 binds RAC1:GTP See in Reactome R-HSA-3928620 ( R-HSA-3928662 ) R-HSA-3928620 Reaction Name: PAK1 autophosphorylates See in Reactome R-HSA-3928625 ( R-HSA-3928664 ) R-HSA-3928625 Reaction Name: PAKs autophosphorylate See in Reactome R-HSA-3928628 ( R-HSA-3928665 ) R-HSA-3928628 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928633 ( R-HSA-3928664 ) R-HSA-3928633 Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it See in Reactome R-HSA-3928640 ( R-HSA-3928664 ) R-HSA-3928640 Reaction Name: PAKs phosphorylate MLC See in Reactome R-HSA-3928641 ( R-HSA-3928664 ) R-HSA-3928641 Reaction Name: PAK binds RAC and bPIX See in Reactome R-HSA-3928642 ( R-HSA-3928665 ) R-HSA-3928642 Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-399928 ( R-HSA-399955 ) R-HSA-399928 Reaction Name: Recruitment of Rnd1 to Plexin A See in Reactome R-HSA-399930 ( R-HSA-399954 ) R-HSA-399930 Reaction Name: Activation of PAK by Rac1 See in Reactome R-HSA-399935 ( R-HSA-399955 ) R-HSA-399935 Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity See in Reactome R-HSA-399938 ( R-HSA-399955 ) R-HSA-399938 Reaction Name: Activation of Rac1 by FARP2 See in Reactome R-HSA-399939 ( R-HSA-399954 ) R-HSA-399939 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-399941 ( R-HSA-399955 ) R-HSA-399941 Reaction Name: Rac1 binds PlexinA See in Reactome R-HSA-399952 ( R-HSA-399954 ) R-HSA-399952 Reaction Name: Phosphorylation of LIMK-1 by PAK See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-4093336 ( R-HSA-3928662 ) R-HSA-4093336 Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-418856 ( R-HSA-418885 ) R-HSA-418856 Reaction Name: Activation of Rac1 See in Reactome R-HSA-418865 ( R-HSA-418885 ) R-HSA-418865 Reaction Name: Recruitment of ABLIM to the plasma membrane See in Reactome R-HSA-428522 ( R-HSA-428543 ) R-HSA-428522 Reaction Name: Inactivation of RAC1 See in Reactome R-HSA-428535 ( R-HSA-428540 ) R-HSA-428535 Reaction Name: Activation of RAC1 by SOS See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442592 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-442592 Reaction Name: WASPs or WAVEs activate the ARP2/3 complex See in Reactome R-HSA-445064 ( R-HSA-445144 ) R-HSA-445064 Reaction Name: Activation of Rac1 by VAV2 See in Reactome R-HSA-445072 ( R-HSA-445144 ) R-HSA-445072 Reaction Name: Interaction of PAK1 with Rac1-GTP See in Reactome R-HSA-451347 ( R-HSA-376172 ) R-HSA-451347 Reaction Name: Activation of JNK by DSCAM See in Reactome R-HSA-451366 ( R-HSA-376172 ) R-HSA-451366 Reaction Name: Activation of p38MAPK by DSCAM See in Reactome R-HSA-5218827 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218827 Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1 See in Reactome R-HSA-5218839 ( R-HSA-4420097 ) R-HSA-5218839 Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1 See in Reactome R-HSA-5218841 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218841 Reaction Name: NADPH oxidase 2 generates superoxide from oxygen See in Reactome R-HSA-5218850 ( R-HSA-4420097 ) R-HSA-5218850 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-5357445 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357445 Reaction Name: PAK1-3 dimer disassociates See in Reactome R-HSA-5357472 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357472 Reaction Name: PAK1-3 autophosphorylates See in Reactome R-HSA-5357483 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357483 Reaction Name: RAC1 binds PAK1-3 See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5626469 ( R-HSA-5626467 ) R-HSA-5626469 Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs See in Reactome R-HSA-5626507 ( R-HSA-5626467 ) R-HSA-5626507 Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin See in Reactome R-HSA-5626549 ( R-HSA-5626467 ) R-HSA-5626549 Reaction Name: IQGAPs bind CALM1 See in Reactome R-HSA-5627775 ( R-HSA-5627123; R-HSA-5687128 ) R-HSA-5627775 Reaction Name: Autophosphorylation of PAK1,2,3 See in Reactome R-HSA-5663232 ( R-HSA-5663220 ) R-HSA-5663232 Reaction Name: FMNL1 binds RAC1:GTP See in Reactome R-HSA-5665659 ( R-HSA-5663220 ) R-HSA-5665659 Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin See in Reactome R-HSA-5665802 ( R-HSA-5663220 ) R-HSA-5665802 Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin See in Reactome R-HSA-5665809 ( R-HSA-5663220 ) R-HSA-5665809 Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments See in Reactome R-HSA-5668714 ( R-HSA-5668599 ) R-HSA-5668714 Reaction Name: RAC1:GTP binds NOX1 complex See in Reactome R-HSA-5668718 ( R-HSA-5668599 ) R-HSA-5668718 Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668731 ( R-HSA-5668599 ) R-HSA-5668731 Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668735 ( R-HSA-5668599 ) R-HSA-5668735 Reaction Name: RAC1:GTP binds NOX3 complex See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5672304 ( R-HSA-5626467 ) R-HSA-5672304 Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 See in Reactome R-HSA-5672329 ( R-HSA-5626467 ) R-HSA-5672329 Reaction Name: IQGAP1 binds CLIP1 and microtubules See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8848618 ( R-HSA-8849471 ) R-HSA-8848618 Reaction Name: Activation of RAC1 by the PXN:CRK complex See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8951586 ( R-HSA-4420097 ) R-HSA-8951586 Reaction Name: p-VAV family:PIP3 binds RAC1:GDP See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981926 ( R-HSA-5627123 ) R-HSA-8981926 Reaction Name: RAC1 and CDC42 activate PAK3 See in Reactome R-HSA-8981931 ( R-HSA-5627123 ) R-HSA-8981931 Reaction Name: RAC1 and CDC42 activate PAK2 See in Reactome R-HSA-9013143 ( R-HSA-9013149 ) R-HSA-9013143 Reaction Name: RAC1 GEFs activate RAC1 See in Reactome R-HSA-9013144 ( R-HSA-9013149 ) R-HSA-9013144 Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9013147 ( R-HSA-9013149 ) R-HSA-9013147 Reaction Name: RAC1 GDIs block activation of RAC1 See in Reactome R-HSA-9032798 ( R-HSA-9032759 ) R-HSA-9032798 Reaction Name: DOCK3 activates RAC1 See in Reactome R-HSA-9033292 ( R-HSA-9032845 ) R-HSA-9033292 Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1 See in Reactome R-HSA-9619803 ( R-HSA-9619229 ) R-HSA-9619803 Reaction Name: p-S516-ARHGEF7 activates RAC1 See in Reactome R-HSA-9691168 ( R-HSA-9013149 ) R-HSA-9691168 Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane See in Reactome R-HSA-9691174 ( R-HSA-9013149 ) R-HSA-9691174 Reaction Name: RAC1 binds effectors at the ER membrane See in Reactome
MONDO:0005097	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-8939211; R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-8939211; R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-8939211; R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0005233	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-8939211; R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-8939211; R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-8939211; R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0005335	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-8939211; R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-8939211; R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-8939211; R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0005486	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0005580	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-8939211; R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-8939211; R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-8939211; R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0007265	MAP2K2	P36507	2.7.12.2	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Signal Transduction Developmental Biology	R-HSA-109858 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-109862 ( R-HSA-112409; R-HSA-112411; R-HSA-445144 ) R-HSA-109862 Reaction Name: MAP2K2 phosphorylates MAPK1 See in Reactome R-HSA-109864 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109864 Reaction Name: Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674366 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674366 Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs See in Reactome R-HSA-5674373 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674373 Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane See in Reactome R-HSA-5674496 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5674496 Reaction Name: Activated MAPKs phosphorylate MAP2K1 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome
MONDO:0007400	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0007794	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0007844	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0007893	MAP2K2	P36507	2.7.12.2	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Signal Transduction Developmental Biology	R-HSA-109858 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-109862 ( R-HSA-112409; R-HSA-112411; R-HSA-445144 ) R-HSA-109862 Reaction Name: MAP2K2 phosphorylates MAPK1 See in Reactome R-HSA-109864 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109864 Reaction Name: Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674366 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674366 Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs See in Reactome R-HSA-5674373 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674373 Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane See in Reactome R-HSA-5674496 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5674496 Reaction Name: Activated MAPKs phosphorylate MAP2K1 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome
MONDO:0007970	MAP2K1	Q02750	2.7.12.2	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-5684264 R-HSA-5684264 Reactome Name: MAP3K8 (TPL2)-dependent MAPK1/3 activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome	Developmental Biology Immune System Signal Transduction	R-HSA-109857 ( R-HSA-110056; R-HSA-112409 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109860 ( R-HSA-110056; R-HSA-112409; R-HSA-445144 ) R-HSA-109860 Reaction Name: MAP2K1 phosphorylates MAPK3 See in Reactome R-HSA-109863 ( R-HSA-110056; R-HSA-112409 ) R-HSA-109863 Reaction Name: Dissociation of p-T,Y-MAPK3:MAP2K1 See in Reactome R-HSA-112342 ( R-HSA-110056; R-HSA-112409 ) R-HSA-112342 Reaction Name: Inactivation of MAP2K1 by CDK1 See in Reactome R-HSA-451649 ( R-HSA-5684264 ) R-HSA-451649 Reaction Name: TPL2 phosphorylates MEK1, SEK1 See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674366 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674366 Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs See in Reactome R-HSA-5674373 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674373 Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane See in Reactome R-HSA-5674496 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5674496 Reaction Name: Activated MAPKs phosphorylate MAP2K1 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome
MONDO:0008021	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-8939211; R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-8939211; R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-8939211; R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0008104	MAP2K1	Q02750	2.7.12.2	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-5684264 R-HSA-5684264 Reactome Name: MAP3K8 (TPL2)-dependent MAPK1/3 activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome	Developmental Biology Immune System Signal Transduction	R-HSA-109857 ( R-HSA-110056; R-HSA-112409 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109860 ( R-HSA-110056; R-HSA-112409; R-HSA-445144 ) R-HSA-109860 Reaction Name: MAP2K1 phosphorylates MAPK3 See in Reactome R-HSA-109863 ( R-HSA-110056; R-HSA-112409 ) R-HSA-109863 Reaction Name: Dissociation of p-T,Y-MAPK3:MAP2K1 See in Reactome R-HSA-112342 ( R-HSA-110056; R-HSA-112409 ) R-HSA-112342 Reaction Name: Inactivation of MAP2K1 by CDK1 See in Reactome R-HSA-451649 ( R-HSA-5684264 ) R-HSA-451649 Reaction Name: TPL2 phosphorylates MEK1, SEK1 See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674366 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674366 Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs See in Reactome R-HSA-5674373 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674373 Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane See in Reactome R-HSA-5674496 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5674496 Reaction Name: Activated MAPKs phosphorylate MAP2K1 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome
MONDO:0008150	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0008315	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-8939211; R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-8939211; R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-8939211; R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0008428	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0008603	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0009327	MAPK1	P28482	2.7.11.24	R-HSA-2559585 R-HSA-2559585 Reactome Name: Oncogene Induced Senescence See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-111995 R-HSA-111995 Reactome Name: phospho-PLA2 pathway See in Reactome R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-198753 R-HSA-198753 Reactome Name: ERK/MAPK targets See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-444257 R-HSA-444257 Reactome Name: RSK activation See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-1181150 R-HSA-1181150 Reactome Name: Signaling by NODAL See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-2173796 R-HSA-2173796 Reactome Name: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-1502540 R-HSA-1502540 Reactome Name: Signaling by Activin See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-450341 R-HSA-450341 Reactome Name: Activation of the AP-1 family of transcription factors See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-74749 R-HSA-74749 Reactome Name: Signal attenuation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-202670 R-HSA-202670 Reactome Name: ERKs are inactivated See in Reactome R-HSA-879415 R-HSA-879415 Reactome Name: Advanced glycosylation endproduct receptor signaling See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-162658 R-HSA-162658 Reactome Name: Golgi Cisternae Pericentriolar Stack Reorganization See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-9627069 R-HSA-9627069 Reactome Name: Regulation of the apoptosome activity See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-3371453 R-HSA-3371453 Reactome Name: Regulation of HSF1-mediated heat shock response See in Reactome	R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-111471 R-HSA-111471 Reactome Name: Apoptotic factor-mediated response See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-450282 R-HSA-450282 Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-111461 R-HSA-111461 Reactome Name: Cytochrome c-mediated apoptotic response See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-68875 R-HSA-68875 Reactome Name: Mitotic Prophase See in Reactome R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-2173793 R-HSA-2173793 Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-111458 R-HSA-111458 Reactome Name: Formation of apoptosome See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Developmental Biology Neuronal System Immune System Programmed Cell Death Gene expression (Transcription) Cellular responses to stimuli Hemostasis Signal Transduction	R-HSA-109822 ( R-HSA-74749 ) R-HSA-109822 Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 See in Reactome R-HSA-109823 ( R-HSA-74749 ) R-HSA-109823 Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 See in Reactome R-HSA-109858 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-109862 ( R-HSA-112409; R-HSA-112411; R-HSA-445144 ) R-HSA-109862 Reaction Name: MAP2K2 phosphorylates MAPK1 See in Reactome R-HSA-109864 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109864 Reaction Name: Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 See in Reactome R-HSA-111898 ( R-HSA-111995 ) R-HSA-111898 Reaction Name: Phosphorylation of cPLA2 by ERK-2 See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-1295634 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-168053 ( R-HSA-450341 ) R-HSA-168053 Reaction Name: Phosphorylated MAPKs phosphorylate ATF-2 See in Reactome R-HSA-173488 ( R-HSA-1181150; R-HSA-1502540; R-HSA-2173796 ) R-HSA-173488 Reaction Name: The SMAD2/3:SMAD4 complex transfers to the nucleus See in Reactome R-HSA-198731 ( R-HSA-198753; R-HSA-8939211; R-HSA-9634638 ) R-HSA-198731 Reaction Name: ERK1/2 activates ELK1 See in Reactome R-HSA-198746 ( R-HSA-198753; R-HSA-2559582; R-HSA-881907 ) R-HSA-198746 Reaction Name: ERK1/2/5 activate RSK1/2/3 See in Reactome R-HSA-198756 ( R-HSA-198753; R-HSA-375165 ) R-HSA-198756 Reaction Name: ERK1/2 phosphorylates MSK1 See in Reactome R-HSA-199959 ( R-HSA-198753; R-HSA-202670 ) R-HSA-199959 Reaction Name: ERKs are inactivated by protein phosphatase 2A See in Reactome R-HSA-2029469 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029469 Reaction Name: p-ERK phosphorylates WAVEs and ABI See in Reactome R-HSA-203797 ( R-HSA-198753; R-HSA-202670 ) R-HSA-203797 Reaction Name: ERKs are inactivated by dual-specific phosphatases (DUSPs) See in Reactome R-HSA-2422927 ( R-HSA-162658 ) R-HSA-2422927 Reaction Name: MAPK3-3 or MAPK1 phosphorylate GORASP2 See in Reactome R-HSA-3132737 ( R-HSA-2559585 ) R-HSA-3132737 Reaction Name: MAPKs phosphorylate ETS1 and ETS2 See in Reactome R-HSA-3209160 ( R-HSA-2559585 ) R-HSA-3209160 Reaction Name: Activated ERKs phosphorylate ERF See in Reactome R-HSA-3209177 ( R-HSA-2559585 ) R-HSA-3209177 Reaction Name: ERF binds ETS2 promoter See in Reactome R-HSA-3223236 ( R-HSA-2559580 ) R-HSA-3223236 Reaction Name: RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS) See in Reactome R-HSA-3371531 ( R-HSA-3371453 ) R-HSA-3371531 Reaction Name: Constitutive phosphorylation by pERK1/2 See in Reactome R-HSA-3857329 ( R-HSA-2559582 ) R-HSA-3857329 Reaction Name: MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB See in Reactome R-HSA-418158 ( R-HSA-456926 ) R-HSA-418158 Reaction Name: SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) See in Reactome R-HSA-418163 ( R-HSA-456926 ) R-HSA-418163 Reaction Name: Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) See in Reactome R-HSA-418170 ( R-HSA-456926 ) R-HSA-418170 Reaction Name: F2R:ARRB1 binds MAPKs, SRC-1 See in Reactome R-HSA-418176 ( R-HSA-456926 ) R-HSA-418176 Reaction Name: F2R:ARRB2 binds MAPKs, SRC-1 See in Reactome R-HSA-418200 ( R-HSA-456926 ) R-HSA-418200 Reaction Name: SRC-1 bound to ARRB2 is not activated See in Reactome R-HSA-445079 ( R-HSA-437239 ) R-HSA-445079 Reaction Name: Phosphorylation of L1 by ERK See in Reactome R-HSA-450325 ( R-HSA-2559580; R-HSA-2871796; R-HSA-450341 ) R-HSA-450325 Reaction Name: c-FOS activation by phospho ERK1/2 See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654562 ( R-HSA-5654727 ) R-HSA-5654562 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 See in Reactome R-HSA-5654565 ( R-HSA-5654732 ) R-HSA-5654565 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. See in Reactome R-HSA-5654566 ( R-HSA-5654733 ) R-HSA-5654566 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674366 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674366 Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs See in Reactome R-HSA-5674373 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674373 Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane See in Reactome R-HSA-5674385 ( R-HSA-112409; R-HSA-170968; R-HSA-5673001 ) R-HSA-5674385 Reaction Name: p-T,Y MAPKs dimerize See in Reactome R-HSA-5674387 ( R-HSA-112409; R-HSA-5673001 ) R-HSA-5674387 Reaction Name: Phosphorylated MAPKs translocate into the nucleus See in Reactome R-HSA-5674496 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5674496 Reaction Name: Activated MAPKs phosphorylate MAP2K1 See in Reactome R-HSA-5675194 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675194 Reaction Name: Activated MAPK phosphorylates RAF1 See in Reactome R-HSA-5675198 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675206 ( R-HSA-112409; R-HSA-5673001 ) R-HSA-5675206 Reaction Name: PEA15 binds MAPK monomers and dimers See in Reactome R-HSA-5675373 ( R-HSA-112409; R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675373 Reaction Name: Nuclear DUSPs dephosphorylate MAPKs See in Reactome R-HSA-5675376 ( R-HSA-112409; R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675376 Reaction Name: Cytosolic DUSPs dephosphorylate MAPKs See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-6811454 ( R-HSA-6811558 ) R-HSA-6811454 Reaction Name: MAPKs phosphorylate PP2A See in Reactome R-HSA-6811472 ( R-HSA-6811558 ) R-HSA-6811472 Reaction Name: IER3 recruits MAPKs to PP2A-B56-beta,gamma See in Reactome R-HSA-879362 ( R-HSA-879415 ) R-HSA-879362 Reaction Name: AGER binds ERK1/2 See in Reactome R-HSA-8944047 ( R-HSA-8943724 ) R-HSA-8944047 Reaction Name: JUN binds the PTEN gene promoter See in Reactome R-HSA-9009208 ( R-HSA-8940973 ) R-HSA-9009208 Reaction Name: Activated ERKs phosphorylate RUNX2 See in Reactome R-HSA-9032751 ( R-HSA-8939211 ) R-HSA-9032751 Reaction Name: Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610166 ( R-HSA-170968 ) R-HSA-9610166 Reaction Name: p-T,Y MAPK dimers translocate to nucleus See in Reactome R-HSA-9619843 ( R-HSA-444257 ) R-HSA-9619843 Reaction Name: ERKs phosphorylate RSKs See in Reactome R-HSA-9626832 ( R-HSA-5668599 ) R-HSA-9626832 Reaction Name: MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 See in Reactome R-HSA-9627089 ( R-HSA-9627069 ) R-HSA-9627089 Reaction Name: CASP9 is phosphorylated at T125 See in Reactome R-HSA-9632873 ( R-HSA-8939211; R-HSA-9634638 ) R-HSA-9632873 Reaction Name: p-S10 CDKN1B translocates to the cytosol See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9635739 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-9635739 Reaction Name: PTPN7 dephosphorylates p-T,Y-MAPKs See in Reactome R-HSA-9635743 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-9635743 Reaction Name: PTPN7 binds p-T,Y-MAPK See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome
MONDO:0010150	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-8939211; R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-8939211; R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-8939211; R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0010150	RAC1	P63000	3.6.5.2	R-HSA-376172 R-HSA-376172 Reactome Name: DSCAM interactions See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-9619229 R-HSA-9619229 Reactome Name: Activation of RAC1 downstream of NMDARs See in Reactome R-HSA-428540 R-HSA-428540 Reactome Name: Activation of RAC1 See in Reactome R-HSA-428543 R-HSA-428543 Reactome Name: Inactivation of CDC42 and RAC1 See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-399954 R-HSA-399954 Reactome Name: Sema3A PAK dependent Axon repulsion See in Reactome R-HSA-9032845 R-HSA-9032845 Reactome Name: Activated NTRK2 signals through CDK5 See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-193648 R-HSA-193648 Reactome Name: NRAGE signals death through JNK See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-9032759 R-HSA-9032759 Reactome Name: NTRK2 activates RAC1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-389359 R-HSA-389359 Reactome Name: CD28 dependent Vav1 pathway See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome R-HSA-399955 R-HSA-399955 Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion See in Reactome R-HSA-5626467 R-HSA-5626467 Reactome Name: RHO GTPases activate IQGAPs See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Developmental Biology Neuronal System Vesicle-mediated transport Hemostasis Signal Transduction	R-HSA-1011598 ( R-HSA-983231 ) R-HSA-1011598 Reaction Name: DOCKs bind to RhoGEFs See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1433415 ( R-HSA-1433557 ) R-HSA-1433415 Reaction Name: Activation of RAC1 See in Reactome R-HSA-2029451 ( R-HSA-2029482 ) R-HSA-2029451 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2029454 ( R-HSA-2029482 ) R-HSA-2029454 Reaction Name: Autophosphorylation of PAK1 See in Reactome R-HSA-2029456 ( R-HSA-2029482; R-HSA-5627123 ) R-HSA-2029456 Reaction Name: RAC1 and CDC42 activate PAK1 See in Reactome R-HSA-2029465 ( R-HSA-2029482; R-HSA-4420097; R-HSA-5663213 ) R-HSA-2029465 Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) See in Reactome R-HSA-2029466 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029466 Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin See in Reactome R-HSA-2029467 ( R-HSA-2029482 ) R-HSA-2029467 Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO See in Reactome R-HSA-2029469 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029469 Reaction Name: p-ERK phosphorylates WAVEs and ABI See in Reactome R-HSA-205039 ( R-HSA-193648 ) R-HSA-205039 Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor See in Reactome R-HSA-205136 ( R-HSA-193648 ) R-HSA-205136 Reaction Name: GTP-bound RAC contributes to JNK activation See in Reactome R-HSA-2130194 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2130194 Reaction Name: ABL phosphorylates WAVEs See in Reactome R-HSA-2197690 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2197690 Reaction Name: Detachment of WASP/WAVE See in Reactome R-HSA-2316352 ( R-HSA-1445148 ) R-HSA-2316352 Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424476 ( R-HSA-2424491 ) R-HSA-2424476 Reaction Name: Activation of RAC1 by VAV2/3 See in Reactome R-HSA-2730840 ( R-HSA-2871796 ) R-HSA-2730840 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2730856 ( R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730889 ( R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-376123 ( R-HSA-376172 ) R-HSA-376123 Reaction Name: DSCAM associates with Rac1-GTP:pPAK1 See in Reactome R-HSA-3858475 ( R-HSA-4086400 ) R-HSA-3858475 Reaction Name: ppDVL recruits RAC See in Reactome R-HSA-389348 ( R-HSA-389359 ) R-HSA-389348 Reaction Name: Activation of Rac1 by pVav1 See in Reactome R-HSA-389788 ( R-HSA-389359; R-HSA-5687128 ) R-HSA-389788 Reaction Name: Activation of PAKs by RAC1 and CDC42 See in Reactome R-HSA-3928612 ( R-HSA-3928662 ) R-HSA-3928612 Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928619 ( R-HSA-3928662 ) R-HSA-3928619 Reaction Name: PAK1 binds RAC1:GTP See in Reactome R-HSA-3928620 ( R-HSA-3928662 ) R-HSA-3928620 Reaction Name: PAK1 autophosphorylates See in Reactome R-HSA-3928625 ( R-HSA-3928664 ) R-HSA-3928625 Reaction Name: PAKs autophosphorylate See in Reactome R-HSA-3928628 ( R-HSA-3928665 ) R-HSA-3928628 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928633 ( R-HSA-3928664 ) R-HSA-3928633 Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it See in Reactome R-HSA-3928640 ( R-HSA-3928664 ) R-HSA-3928640 Reaction Name: PAKs phosphorylate MLC See in Reactome R-HSA-3928641 ( R-HSA-3928664 ) R-HSA-3928641 Reaction Name: PAK binds RAC and bPIX See in Reactome R-HSA-3928642 ( R-HSA-3928665 ) R-HSA-3928642 Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-399928 ( R-HSA-399955 ) R-HSA-399928 Reaction Name: Recruitment of Rnd1 to Plexin A See in Reactome R-HSA-399930 ( R-HSA-399954 ) R-HSA-399930 Reaction Name: Activation of PAK by Rac1 See in Reactome R-HSA-399935 ( R-HSA-399955 ) R-HSA-399935 Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity See in Reactome R-HSA-399938 ( R-HSA-399955 ) R-HSA-399938 Reaction Name: Activation of Rac1 by FARP2 See in Reactome R-HSA-399939 ( R-HSA-399954 ) R-HSA-399939 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-399941 ( R-HSA-399955 ) R-HSA-399941 Reaction Name: Rac1 binds PlexinA See in Reactome R-HSA-399952 ( R-HSA-399954 ) R-HSA-399952 Reaction Name: Phosphorylation of LIMK-1 by PAK See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-4093336 ( R-HSA-3928662 ) R-HSA-4093336 Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-418856 ( R-HSA-418885 ) R-HSA-418856 Reaction Name: Activation of Rac1 See in Reactome R-HSA-418865 ( R-HSA-418885 ) R-HSA-418865 Reaction Name: Recruitment of ABLIM to the plasma membrane See in Reactome R-HSA-428522 ( R-HSA-428543 ) R-HSA-428522 Reaction Name: Inactivation of RAC1 See in Reactome R-HSA-428535 ( R-HSA-428540 ) R-HSA-428535 Reaction Name: Activation of RAC1 by SOS See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442592 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-442592 Reaction Name: WASPs or WAVEs activate the ARP2/3 complex See in Reactome R-HSA-445064 ( R-HSA-445144 ) R-HSA-445064 Reaction Name: Activation of Rac1 by VAV2 See in Reactome R-HSA-445072 ( R-HSA-445144 ) R-HSA-445072 Reaction Name: Interaction of PAK1 with Rac1-GTP See in Reactome R-HSA-451347 ( R-HSA-376172 ) R-HSA-451347 Reaction Name: Activation of JNK by DSCAM See in Reactome R-HSA-451366 ( R-HSA-376172 ) R-HSA-451366 Reaction Name: Activation of p38MAPK by DSCAM See in Reactome R-HSA-5218827 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218827 Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1 See in Reactome R-HSA-5218839 ( R-HSA-4420097 ) R-HSA-5218839 Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1 See in Reactome R-HSA-5218841 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218841 Reaction Name: NADPH oxidase 2 generates superoxide from oxygen See in Reactome R-HSA-5218850 ( R-HSA-4420097 ) R-HSA-5218850 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-5357445 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357445 Reaction Name: PAK1-3 dimer disassociates See in Reactome R-HSA-5357472 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357472 Reaction Name: PAK1-3 autophosphorylates See in Reactome R-HSA-5357483 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357483 Reaction Name: RAC1 binds PAK1-3 See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5626469 ( R-HSA-5626467 ) R-HSA-5626469 Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs See in Reactome R-HSA-5626507 ( R-HSA-5626467 ) R-HSA-5626507 Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin See in Reactome R-HSA-5626549 ( R-HSA-5626467 ) R-HSA-5626549 Reaction Name: IQGAPs bind CALM1 See in Reactome R-HSA-5627775 ( R-HSA-5627123; R-HSA-5687128 ) R-HSA-5627775 Reaction Name: Autophosphorylation of PAK1,2,3 See in Reactome R-HSA-5663232 ( R-HSA-5663220 ) R-HSA-5663232 Reaction Name: FMNL1 binds RAC1:GTP See in Reactome R-HSA-5665659 ( R-HSA-5663220 ) R-HSA-5665659 Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin See in Reactome R-HSA-5665802 ( R-HSA-5663220 ) R-HSA-5665802 Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin See in Reactome R-HSA-5665809 ( R-HSA-5663220 ) R-HSA-5665809 Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments See in Reactome R-HSA-5668714 ( R-HSA-5668599 ) R-HSA-5668714 Reaction Name: RAC1:GTP binds NOX1 complex See in Reactome R-HSA-5668718 ( R-HSA-5668599 ) R-HSA-5668718 Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668731 ( R-HSA-5668599 ) R-HSA-5668731 Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668735 ( R-HSA-5668599 ) R-HSA-5668735 Reaction Name: RAC1:GTP binds NOX3 complex See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5672304 ( R-HSA-5626467 ) R-HSA-5672304 Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 See in Reactome R-HSA-5672329 ( R-HSA-5626467 ) R-HSA-5672329 Reaction Name: IQGAP1 binds CLIP1 and microtubules See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8848618 ( R-HSA-8849471 ) R-HSA-8848618 Reaction Name: Activation of RAC1 by the PXN:CRK complex See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8951586 ( R-HSA-4420097 ) R-HSA-8951586 Reaction Name: p-VAV family:PIP3 binds RAC1:GDP See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981926 ( R-HSA-5627123 ) R-HSA-8981926 Reaction Name: RAC1 and CDC42 activate PAK3 See in Reactome R-HSA-8981931 ( R-HSA-5627123 ) R-HSA-8981931 Reaction Name: RAC1 and CDC42 activate PAK2 See in Reactome R-HSA-9013143 ( R-HSA-9013149 ) R-HSA-9013143 Reaction Name: RAC1 GEFs activate RAC1 See in Reactome R-HSA-9013144 ( R-HSA-9013149 ) R-HSA-9013144 Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9013147 ( R-HSA-9013149 ) R-HSA-9013147 Reaction Name: RAC1 GDIs block activation of RAC1 See in Reactome R-HSA-9032798 ( R-HSA-9032759 ) R-HSA-9032798 Reaction Name: DOCK3 activates RAC1 See in Reactome R-HSA-9033292 ( R-HSA-9032845 ) R-HSA-9033292 Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1 See in Reactome R-HSA-9619803 ( R-HSA-9619229 ) R-HSA-9619803 Reaction Name: p-S516-ARHGEF7 activates RAC1 See in Reactome R-HSA-9691168 ( R-HSA-9013149 ) R-HSA-9691168 Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane See in Reactome R-HSA-9691174 ( R-HSA-9013149 ) R-HSA-9691174 Reaction Name: RAC1 binds effectors at the ER membrane See in Reactome
MONDO:0011035	MAP2K2	P36507	2.7.12.2	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Signal Transduction Developmental Biology	R-HSA-109858 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-109862 ( R-HSA-112409; R-HSA-112411; R-HSA-445144 ) R-HSA-109862 Reaction Name: MAP2K2 phosphorylates MAPK1 See in Reactome R-HSA-109864 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109864 Reaction Name: Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674366 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674366 Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs See in Reactome R-HSA-5674373 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674373 Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane See in Reactome R-HSA-5674496 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5674496 Reaction Name: Activated MAPKs phosphorylate MAP2K1 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome
MONDO:0013074	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0014113	MAP2K1	Q02750	2.7.12.2	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-5684264 R-HSA-5684264 Reactome Name: MAP3K8 (TPL2)-dependent MAPK1/3 activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome	Developmental Biology Immune System Signal Transduction	R-HSA-109857 ( R-HSA-110056; R-HSA-112409 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109860 ( R-HSA-110056; R-HSA-112409; R-HSA-445144 ) R-HSA-109860 Reaction Name: MAP2K1 phosphorylates MAPK3 See in Reactome R-HSA-109863 ( R-HSA-110056; R-HSA-112409 ) R-HSA-109863 Reaction Name: Dissociation of p-T,Y-MAPK3:MAP2K1 See in Reactome R-HSA-112342 ( R-HSA-110056; R-HSA-112409 ) R-HSA-112342 Reaction Name: Inactivation of MAP2K1 by CDK1 See in Reactome R-HSA-451649 ( R-HSA-5684264 ) R-HSA-451649 Reaction Name: TPL2 phosphorylates MEK1, SEK1 See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674366 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674366 Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs See in Reactome R-HSA-5674373 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674373 Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane See in Reactome R-HSA-5674496 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5674496 Reaction Name: Activated MAPKs phosphorylate MAP2K1 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome
MONDO:0014114	MAP2K2	P36507	2.7.12.2	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Signal Transduction Developmental Biology	R-HSA-109858 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-109862 ( R-HSA-112409; R-HSA-112411; R-HSA-445144 ) R-HSA-109862 Reaction Name: MAP2K2 phosphorylates MAPK1 See in Reactome R-HSA-109864 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109864 Reaction Name: Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674366 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674366 Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs See in Reactome R-HSA-5674373 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674373 Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane See in Reactome R-HSA-5674496 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5674496 Reaction Name: Activated MAPKs phosphorylate MAP2K1 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome
MONDO:0014196	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0014481	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-8939211; R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-8939211; R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-8939211; R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0014893	CSNK2A1	P68400	2.7.11.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1483191 R-HSA-1483191 Reactome Name: Synthesis of PC See in Reactome R-HSA-6814122 R-HSA-6814122 Reactome Name: Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding See in Reactome R-HSA-8939243 R-HSA-8939243 Reactome Name: RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-201688 R-HSA-201688 Reactome Name: WNT mediated activation of DVL See in Reactome R-HSA-2514853 R-HSA-2514853 Reactome Name: Condensation of Prometaphase Chromosomes See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-8934903 R-HSA-8934903 Reactome Name: Receptor Mediated Mitophagy See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-390466 R-HSA-390466 Reactome Name: Chaperonin-mediated protein folding See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-5205647 R-HSA-5205647 Reactome Name: Mitophagy See in Reactome R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-391251 R-HSA-391251 Reactome Name: Protein folding See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-1483206 R-HSA-1483206 Reactome Name: Glycerophospholipid biosynthesis See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-68877 R-HSA-68877 Reactome Name: Mitotic Prometaphase See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Autophagy Metabolism of proteins Signal Transduction	R-HSA-201717 ( R-HSA-201688 ) R-HSA-201717 Reaction Name: CSNK2-mediated phosphorylation of DVL See in Reactome R-HSA-2529020 ( R-HSA-2514853 ) R-HSA-2529020 Reaction Name: CK2 phosphorylates condensin I subunits See in Reactome R-HSA-392752 ( R-HSA-445144 ) R-HSA-392752 Reaction Name: Phosphorylation of L1 by CK-II See in Reactome R-HSA-6805059 ( R-HSA-6804756 ) R-HSA-6805059 Reaction Name: CK2:FACT phosphorylates TP53 See in Reactome R-HSA-6805061 ( R-HSA-6804756 ) R-HSA-6805061 Reaction Name: CK2 binds FACT See in Reactome R-HSA-6814409 ( R-HSA-6814122 ) R-HSA-6814409 Reaction Name: CK2 phosphorylates PDCL See in Reactome R-HSA-8850945 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8873929 ( R-HSA-1483191 ) R-HSA-8873929 Reaction Name: Casein kinase II phosphorylates STARD10 See in Reactome R-HSA-8932322 () R-HSA-8932322 Reaction Name: CK2 phosphorylates NFE2L2 See in Reactome R-HSA-8937989 ( R-HSA-8939243 ) R-HSA-8937989 Reaction Name: RUNX1 binds PRC1 complexes See in Reactome R-HSA-8948039 ( R-HSA-8934903 ) R-HSA-8948039 Reaction Name: FUNDC1 is phosphorylated by CK2 See in Reactome
MONDO:0016225	MAPK1	P28482	2.7.11.24	R-HSA-2559585 R-HSA-2559585 Reactome Name: Oncogene Induced Senescence See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-111995 R-HSA-111995 Reactome Name: phospho-PLA2 pathway See in Reactome R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-198753 R-HSA-198753 Reactome Name: ERK/MAPK targets See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-444257 R-HSA-444257 Reactome Name: RSK activation See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-1181150 R-HSA-1181150 Reactome Name: Signaling by NODAL See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-2173796 R-HSA-2173796 Reactome Name: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-1502540 R-HSA-1502540 Reactome Name: Signaling by Activin See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-450341 R-HSA-450341 Reactome Name: Activation of the AP-1 family of transcription factors See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-74749 R-HSA-74749 Reactome Name: Signal attenuation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-202670 R-HSA-202670 Reactome Name: ERKs are inactivated See in Reactome R-HSA-879415 R-HSA-879415 Reactome Name: Advanced glycosylation endproduct receptor signaling See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-162658 R-HSA-162658 Reactome Name: Golgi Cisternae Pericentriolar Stack Reorganization See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-9627069 R-HSA-9627069 Reactome Name: Regulation of the apoptosome activity See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-3371453 R-HSA-3371453 Reactome Name: Regulation of HSF1-mediated heat shock response See in Reactome	R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-111471 R-HSA-111471 Reactome Name: Apoptotic factor-mediated response See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-450282 R-HSA-450282 Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-111461 R-HSA-111461 Reactome Name: Cytochrome c-mediated apoptotic response See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-68875 R-HSA-68875 Reactome Name: Mitotic Prophase See in Reactome R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-2173793 R-HSA-2173793 Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-111458 R-HSA-111458 Reactome Name: Formation of apoptosome See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Developmental Biology Neuronal System Immune System Programmed Cell Death Gene expression (Transcription) Cellular responses to stimuli Hemostasis Signal Transduction	R-HSA-109822 ( R-HSA-74749 ) R-HSA-109822 Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 See in Reactome R-HSA-109823 ( R-HSA-74749 ) R-HSA-109823 Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 See in Reactome R-HSA-109858 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-109862 ( R-HSA-112409; R-HSA-112411; R-HSA-445144 ) R-HSA-109862 Reaction Name: MAP2K2 phosphorylates MAPK1 See in Reactome R-HSA-109864 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109864 Reaction Name: Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 See in Reactome R-HSA-111898 ( R-HSA-111995 ) R-HSA-111898 Reaction Name: Phosphorylation of cPLA2 by ERK-2 See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-1295634 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-168053 ( R-HSA-450341 ) R-HSA-168053 Reaction Name: Phosphorylated MAPKs phosphorylate ATF-2 See in Reactome R-HSA-173488 ( R-HSA-1181150; R-HSA-1502540; R-HSA-2173796 ) R-HSA-173488 Reaction Name: The SMAD2/3:SMAD4 complex transfers to the nucleus See in Reactome R-HSA-198731 ( R-HSA-198753; R-HSA-8939211; R-HSA-9634638 ) R-HSA-198731 Reaction Name: ERK1/2 activates ELK1 See in Reactome R-HSA-198746 ( R-HSA-198753; R-HSA-2559582; R-HSA-881907 ) R-HSA-198746 Reaction Name: ERK1/2/5 activate RSK1/2/3 See in Reactome R-HSA-198756 ( R-HSA-198753; R-HSA-375165 ) R-HSA-198756 Reaction Name: ERK1/2 phosphorylates MSK1 See in Reactome R-HSA-199959 ( R-HSA-198753; R-HSA-202670 ) R-HSA-199959 Reaction Name: ERKs are inactivated by protein phosphatase 2A See in Reactome R-HSA-2029469 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029469 Reaction Name: p-ERK phosphorylates WAVEs and ABI See in Reactome R-HSA-203797 ( R-HSA-198753; R-HSA-202670 ) R-HSA-203797 Reaction Name: ERKs are inactivated by dual-specific phosphatases (DUSPs) See in Reactome R-HSA-2422927 ( R-HSA-162658 ) R-HSA-2422927 Reaction Name: MAPK3-3 or MAPK1 phosphorylate GORASP2 See in Reactome R-HSA-3132737 ( R-HSA-2559585 ) R-HSA-3132737 Reaction Name: MAPKs phosphorylate ETS1 and ETS2 See in Reactome R-HSA-3209160 ( R-HSA-2559585 ) R-HSA-3209160 Reaction Name: Activated ERKs phosphorylate ERF See in Reactome R-HSA-3209177 ( R-HSA-2559585 ) R-HSA-3209177 Reaction Name: ERF binds ETS2 promoter See in Reactome R-HSA-3223236 ( R-HSA-2559580 ) R-HSA-3223236 Reaction Name: RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS) See in Reactome R-HSA-3371531 ( R-HSA-3371453 ) R-HSA-3371531 Reaction Name: Constitutive phosphorylation by pERK1/2 See in Reactome R-HSA-3857329 ( R-HSA-2559582 ) R-HSA-3857329 Reaction Name: MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB See in Reactome R-HSA-418158 ( R-HSA-456926 ) R-HSA-418158 Reaction Name: SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) See in Reactome R-HSA-418163 ( R-HSA-456926 ) R-HSA-418163 Reaction Name: Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) See in Reactome R-HSA-418170 ( R-HSA-456926 ) R-HSA-418170 Reaction Name: F2R:ARRB1 binds MAPKs, SRC-1 See in Reactome R-HSA-418176 ( R-HSA-456926 ) R-HSA-418176 Reaction Name: F2R:ARRB2 binds MAPKs, SRC-1 See in Reactome R-HSA-418200 ( R-HSA-456926 ) R-HSA-418200 Reaction Name: SRC-1 bound to ARRB2 is not activated See in Reactome R-HSA-445079 ( R-HSA-437239 ) R-HSA-445079 Reaction Name: Phosphorylation of L1 by ERK See in Reactome R-HSA-450325 ( R-HSA-2559580; R-HSA-2871796; R-HSA-450341 ) R-HSA-450325 Reaction Name: c-FOS activation by phospho ERK1/2 See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654562 ( R-HSA-5654727 ) R-HSA-5654562 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 See in Reactome R-HSA-5654565 ( R-HSA-5654732 ) R-HSA-5654565 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. See in Reactome R-HSA-5654566 ( R-HSA-5654733 ) R-HSA-5654566 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674366 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674366 Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs See in Reactome R-HSA-5674373 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674373 Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane See in Reactome R-HSA-5674385 ( R-HSA-112409; R-HSA-170968; R-HSA-5673001 ) R-HSA-5674385 Reaction Name: p-T,Y MAPKs dimerize See in Reactome R-HSA-5674387 ( R-HSA-112409; R-HSA-5673001 ) R-HSA-5674387 Reaction Name: Phosphorylated MAPKs translocate into the nucleus See in Reactome R-HSA-5674496 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5674496 Reaction Name: Activated MAPKs phosphorylate MAP2K1 See in Reactome R-HSA-5675194 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675194 Reaction Name: Activated MAPK phosphorylates RAF1 See in Reactome R-HSA-5675198 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675206 ( R-HSA-112409; R-HSA-5673001 ) R-HSA-5675206 Reaction Name: PEA15 binds MAPK monomers and dimers See in Reactome R-HSA-5675373 ( R-HSA-112409; R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675373 Reaction Name: Nuclear DUSPs dephosphorylate MAPKs See in Reactome R-HSA-5675376 ( R-HSA-112409; R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675376 Reaction Name: Cytosolic DUSPs dephosphorylate MAPKs See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-6811454 ( R-HSA-6811558 ) R-HSA-6811454 Reaction Name: MAPKs phosphorylate PP2A See in Reactome R-HSA-6811472 ( R-HSA-6811558 ) R-HSA-6811472 Reaction Name: IER3 recruits MAPKs to PP2A-B56-beta,gamma See in Reactome R-HSA-879362 ( R-HSA-879415 ) R-HSA-879362 Reaction Name: AGER binds ERK1/2 See in Reactome R-HSA-8944047 ( R-HSA-8943724 ) R-HSA-8944047 Reaction Name: JUN binds the PTEN gene promoter See in Reactome R-HSA-9009208 ( R-HSA-8940973 ) R-HSA-9009208 Reaction Name: Activated ERKs phosphorylate RUNX2 See in Reactome R-HSA-9032751 ( R-HSA-8939211 ) R-HSA-9032751 Reaction Name: Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610166 ( R-HSA-170968 ) R-HSA-9610166 Reaction Name: p-T,Y MAPK dimers translocate to nucleus See in Reactome R-HSA-9619843 ( R-HSA-444257 ) R-HSA-9619843 Reaction Name: ERKs phosphorylate RSKs See in Reactome R-HSA-9626832 ( R-HSA-5668599 ) R-HSA-9626832 Reaction Name: MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 See in Reactome R-HSA-9627089 ( R-HSA-9627069 ) R-HSA-9627089 Reaction Name: CASP9 is phosphorylated at T125 See in Reactome R-HSA-9632873 ( R-HSA-8939211; R-HSA-9634638 ) R-HSA-9632873 Reaction Name: p-S10 CDKN1B translocates to the cytosol See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9635739 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-9635739 Reaction Name: PTPN7 dephosphorylates p-T,Y-MAPKs See in Reactome R-HSA-9635743 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-9635743 Reaction Name: PTPN7 binds p-T,Y-MAPK See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome
MONDO:0016355	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0016692	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0017219	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0018177	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-8939211; R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-8939211; R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-8939211; R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0018997	MAP2K2	P36507	2.7.12.2	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	Signal Transduction Developmental Biology	R-HSA-109858 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-109862 ( R-HSA-112409; R-HSA-112411; R-HSA-445144 ) R-HSA-109862 Reaction Name: MAP2K2 phosphorylates MAPK1 See in Reactome R-HSA-109864 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109864 Reaction Name: Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674366 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674366 Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs See in Reactome R-HSA-5674373 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674373 Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane See in Reactome R-HSA-5674496 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5674496 Reaction Name: Activated MAPKs phosphorylate MAP2K1 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome
MONDO:0019659	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0019756	FGFR1	P11362	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-190374 R-HSA-190374 Reactome Name: FGFR1c and Klotho ligand binding and activation See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-190370 R-HSA-190370 Reactome Name: FGFR1b ligand binding and activation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5654219 R-HSA-5654219 Reactome Name: Phospholipase C-mediated cascade: FGFR1 See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-190373 R-HSA-190373 Reactome Name: FGFR1c ligand binding and activation See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-190242 R-HSA-190242 Reactome Name: FGFR1 ligand binding and activation See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction Developmental Biology	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-190245 ( R-HSA-190370 ) R-HSA-190245 Reaction Name: FGFR1b binds to FGF See in Reactome R-HSA-190256 ( R-HSA-190373 ) R-HSA-190256 Reaction Name: FGFR1c binds to FGF See in Reactome R-HSA-190268 ( R-HSA-190374 ) R-HSA-190268 Reaction Name: FGFR1c binds to Klotho-bound FGF23 See in Reactome R-HSA-190427 ( R-HSA-190370 ) R-HSA-190427 Reaction Name: Autocatalytic phosphorylation of FGFR1b See in Reactome R-HSA-190429 ( R-HSA-190373 ) R-HSA-190429 Reaction Name: Autocatalytic phosphorylation of FGFR1c See in Reactome R-HSA-191062 ( R-HSA-190374 ) R-HSA-191062 Reaction Name: Autocatalytic phosphorylation of Klotho-bound FGFR1c See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-419033 ( R-HSA-375165 ) R-HSA-419033 Reaction Name: NCAM1 binds FGFR-1 See in Reactome R-HSA-437230 ( R-HSA-445144 ) R-HSA-437230 Reaction Name: L1-FGFR cis-heterodimerization See in Reactome R-HSA-5654149 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654149 Reaction Name: Activated FGFR1 phosphorylates PLCG1 See in Reactome R-HSA-5654165 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654165 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR1 See in Reactome R-HSA-5654167 ( R-HSA-5654219; R-HSA-5654687 ) R-HSA-5654167 Reaction Name: Activated FGFR1 binds PLCG1 See in Reactome R-HSA-5654392 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654514 ( R-HSA-5654726 ) R-HSA-5654514 Reaction Name: KAL1 binds FGFR1c See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654569 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654569 Reaction Name: Activated FGFR1 binds FRS2 See in Reactome R-HSA-5654571 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654571 Reaction Name: Activated FGFR1 binds FRS3 See in Reactome R-HSA-5654573 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654573 Reaction Name: Activated FGFR1 binds SHC1 See in Reactome R-HSA-5654575 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654575 Reaction Name: Activated FGFR1 phosphorylates FRS2 See in Reactome R-HSA-5654578 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654578 Reaction Name: Activated FGFR1 phosphorylates FRS3 See in Reactome R-HSA-5654582 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654582 Reaction Name: Activated FGFR1 phosphorylates SHC1 See in Reactome R-HSA-5654584 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654586 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654586 Reaction Name: Activated FGFR1:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654587 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654591 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654592 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654592 Reaction Name: Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654594 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654597 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654597 Reaction Name: Activated FGFR1:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654600 ( R-HSA-5654687; R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654690 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654687; R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5656064 ( R-HSA-5654687 ) R-HSA-5656064 Reaction Name: Activated FGFR1 binds FLRT1 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654687; R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0030913	RAC1	P63000	3.6.5.2	R-HSA-376172 R-HSA-376172 Reactome Name: DSCAM interactions See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-9619229 R-HSA-9619229 Reactome Name: Activation of RAC1 downstream of NMDARs See in Reactome R-HSA-428540 R-HSA-428540 Reactome Name: Activation of RAC1 See in Reactome R-HSA-428543 R-HSA-428543 Reactome Name: Inactivation of CDC42 and RAC1 See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-399954 R-HSA-399954 Reactome Name: Sema3A PAK dependent Axon repulsion See in Reactome R-HSA-9032845 R-HSA-9032845 Reactome Name: Activated NTRK2 signals through CDK5 See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-193648 R-HSA-193648 Reactome Name: NRAGE signals death through JNK See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-9032759 R-HSA-9032759 Reactome Name: NTRK2 activates RAC1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-389359 R-HSA-389359 Reactome Name: CD28 dependent Vav1 pathway See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome R-HSA-399955 R-HSA-399955 Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion See in Reactome R-HSA-5626467 R-HSA-5626467 Reactome Name: RHO GTPases activate IQGAPs See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Developmental Biology Neuronal System Vesicle-mediated transport Hemostasis Signal Transduction	R-HSA-1011598 ( R-HSA-983231 ) R-HSA-1011598 Reaction Name: DOCKs bind to RhoGEFs See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1433415 ( R-HSA-1433557 ) R-HSA-1433415 Reaction Name: Activation of RAC1 See in Reactome R-HSA-2029451 ( R-HSA-2029482 ) R-HSA-2029451 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2029454 ( R-HSA-2029482 ) R-HSA-2029454 Reaction Name: Autophosphorylation of PAK1 See in Reactome R-HSA-2029456 ( R-HSA-2029482; R-HSA-5627123 ) R-HSA-2029456 Reaction Name: RAC1 and CDC42 activate PAK1 See in Reactome R-HSA-2029465 ( R-HSA-2029482; R-HSA-4420097; R-HSA-5663213 ) R-HSA-2029465 Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) See in Reactome R-HSA-2029466 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029466 Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin See in Reactome R-HSA-2029467 ( R-HSA-2029482 ) R-HSA-2029467 Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO See in Reactome R-HSA-2029469 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029469 Reaction Name: p-ERK phosphorylates WAVEs and ABI See in Reactome R-HSA-205039 ( R-HSA-193648 ) R-HSA-205039 Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor See in Reactome R-HSA-205136 ( R-HSA-193648 ) R-HSA-205136 Reaction Name: GTP-bound RAC contributes to JNK activation See in Reactome R-HSA-2130194 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2130194 Reaction Name: ABL phosphorylates WAVEs See in Reactome R-HSA-2197690 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2197690 Reaction Name: Detachment of WASP/WAVE See in Reactome R-HSA-2316352 ( R-HSA-1445148 ) R-HSA-2316352 Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424476 ( R-HSA-2424491 ) R-HSA-2424476 Reaction Name: Activation of RAC1 by VAV2/3 See in Reactome R-HSA-2730840 ( R-HSA-2871796 ) R-HSA-2730840 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2730856 ( R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730889 ( R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-376123 ( R-HSA-376172 ) R-HSA-376123 Reaction Name: DSCAM associates with Rac1-GTP:pPAK1 See in Reactome R-HSA-3858475 ( R-HSA-4086400 ) R-HSA-3858475 Reaction Name: ppDVL recruits RAC See in Reactome R-HSA-389348 ( R-HSA-389359 ) R-HSA-389348 Reaction Name: Activation of Rac1 by pVav1 See in Reactome R-HSA-389788 ( R-HSA-389359; R-HSA-5687128 ) R-HSA-389788 Reaction Name: Activation of PAKs by RAC1 and CDC42 See in Reactome R-HSA-3928612 ( R-HSA-3928662 ) R-HSA-3928612 Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928619 ( R-HSA-3928662 ) R-HSA-3928619 Reaction Name: PAK1 binds RAC1:GTP See in Reactome R-HSA-3928620 ( R-HSA-3928662 ) R-HSA-3928620 Reaction Name: PAK1 autophosphorylates See in Reactome R-HSA-3928625 ( R-HSA-3928664 ) R-HSA-3928625 Reaction Name: PAKs autophosphorylate See in Reactome R-HSA-3928628 ( R-HSA-3928665 ) R-HSA-3928628 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928633 ( R-HSA-3928664 ) R-HSA-3928633 Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it See in Reactome R-HSA-3928640 ( R-HSA-3928664 ) R-HSA-3928640 Reaction Name: PAKs phosphorylate MLC See in Reactome R-HSA-3928641 ( R-HSA-3928664 ) R-HSA-3928641 Reaction Name: PAK binds RAC and bPIX See in Reactome R-HSA-3928642 ( R-HSA-3928665 ) R-HSA-3928642 Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-399928 ( R-HSA-399955 ) R-HSA-399928 Reaction Name: Recruitment of Rnd1 to Plexin A See in Reactome R-HSA-399930 ( R-HSA-399954 ) R-HSA-399930 Reaction Name: Activation of PAK by Rac1 See in Reactome R-HSA-399935 ( R-HSA-399955 ) R-HSA-399935 Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity See in Reactome R-HSA-399938 ( R-HSA-399955 ) R-HSA-399938 Reaction Name: Activation of Rac1 by FARP2 See in Reactome R-HSA-399939 ( R-HSA-399954 ) R-HSA-399939 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-399941 ( R-HSA-399955 ) R-HSA-399941 Reaction Name: Rac1 binds PlexinA See in Reactome R-HSA-399952 ( R-HSA-399954 ) R-HSA-399952 Reaction Name: Phosphorylation of LIMK-1 by PAK See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-4093336 ( R-HSA-3928662 ) R-HSA-4093336 Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-418856 ( R-HSA-418885 ) R-HSA-418856 Reaction Name: Activation of Rac1 See in Reactome R-HSA-418865 ( R-HSA-418885 ) R-HSA-418865 Reaction Name: Recruitment of ABLIM to the plasma membrane See in Reactome R-HSA-428522 ( R-HSA-428543 ) R-HSA-428522 Reaction Name: Inactivation of RAC1 See in Reactome R-HSA-428535 ( R-HSA-428540 ) R-HSA-428535 Reaction Name: Activation of RAC1 by SOS See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442592 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-442592 Reaction Name: WASPs or WAVEs activate the ARP2/3 complex See in Reactome R-HSA-445064 ( R-HSA-445144 ) R-HSA-445064 Reaction Name: Activation of Rac1 by VAV2 See in Reactome R-HSA-445072 ( R-HSA-445144 ) R-HSA-445072 Reaction Name: Interaction of PAK1 with Rac1-GTP See in Reactome R-HSA-451347 ( R-HSA-376172 ) R-HSA-451347 Reaction Name: Activation of JNK by DSCAM See in Reactome R-HSA-451366 ( R-HSA-376172 ) R-HSA-451366 Reaction Name: Activation of p38MAPK by DSCAM See in Reactome R-HSA-5218827 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218827 Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1 See in Reactome R-HSA-5218839 ( R-HSA-4420097 ) R-HSA-5218839 Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1 See in Reactome R-HSA-5218841 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218841 Reaction Name: NADPH oxidase 2 generates superoxide from oxygen See in Reactome R-HSA-5218850 ( R-HSA-4420097 ) R-HSA-5218850 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-5357445 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357445 Reaction Name: PAK1-3 dimer disassociates See in Reactome R-HSA-5357472 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357472 Reaction Name: PAK1-3 autophosphorylates See in Reactome R-HSA-5357483 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357483 Reaction Name: RAC1 binds PAK1-3 See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5626469 ( R-HSA-5626467 ) R-HSA-5626469 Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs See in Reactome R-HSA-5626507 ( R-HSA-5626467 ) R-HSA-5626507 Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin See in Reactome R-HSA-5626549 ( R-HSA-5626467 ) R-HSA-5626549 Reaction Name: IQGAPs bind CALM1 See in Reactome R-HSA-5627775 ( R-HSA-5627123; R-HSA-5687128 ) R-HSA-5627775 Reaction Name: Autophosphorylation of PAK1,2,3 See in Reactome R-HSA-5663232 ( R-HSA-5663220 ) R-HSA-5663232 Reaction Name: FMNL1 binds RAC1:GTP See in Reactome R-HSA-5665659 ( R-HSA-5663220 ) R-HSA-5665659 Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin See in Reactome R-HSA-5665802 ( R-HSA-5663220 ) R-HSA-5665802 Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin See in Reactome R-HSA-5665809 ( R-HSA-5663220 ) R-HSA-5665809 Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments See in Reactome R-HSA-5668714 ( R-HSA-5668599 ) R-HSA-5668714 Reaction Name: RAC1:GTP binds NOX1 complex See in Reactome R-HSA-5668718 ( R-HSA-5668599 ) R-HSA-5668718 Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668731 ( R-HSA-5668599 ) R-HSA-5668731 Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668735 ( R-HSA-5668599 ) R-HSA-5668735 Reaction Name: RAC1:GTP binds NOX3 complex See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5672304 ( R-HSA-5626467 ) R-HSA-5672304 Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 See in Reactome R-HSA-5672329 ( R-HSA-5626467 ) R-HSA-5672329 Reaction Name: IQGAP1 binds CLIP1 and microtubules See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8848618 ( R-HSA-8849471 ) R-HSA-8848618 Reaction Name: Activation of RAC1 by the PXN:CRK complex See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8951586 ( R-HSA-4420097 ) R-HSA-8951586 Reaction Name: p-VAV family:PIP3 binds RAC1:GDP See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981926 ( R-HSA-5627123 ) R-HSA-8981926 Reaction Name: RAC1 and CDC42 activate PAK3 See in Reactome R-HSA-8981931 ( R-HSA-5627123 ) R-HSA-8981931 Reaction Name: RAC1 and CDC42 activate PAK2 See in Reactome R-HSA-9013143 ( R-HSA-9013149 ) R-HSA-9013143 Reaction Name: RAC1 GEFs activate RAC1 See in Reactome R-HSA-9013144 ( R-HSA-9013149 ) R-HSA-9013144 Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9013147 ( R-HSA-9013149 ) R-HSA-9013147 Reaction Name: RAC1 GDIs block activation of RAC1 See in Reactome R-HSA-9032798 ( R-HSA-9032759 ) R-HSA-9032798 Reaction Name: DOCK3 activates RAC1 See in Reactome R-HSA-9033292 ( R-HSA-9032845 ) R-HSA-9033292 Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1 See in Reactome R-HSA-9619803 ( R-HSA-9619229 ) R-HSA-9619803 Reaction Name: p-S516-ARHGEF7 activates RAC1 See in Reactome R-HSA-9691168 ( R-HSA-9013149 ) R-HSA-9691168 Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane See in Reactome R-HSA-9691174 ( R-HSA-9013149 ) R-HSA-9691174 Reaction Name: RAC1 binds effectors at the ER membrane See in Reactome
MONDO:0032568	PAK1	Q13153	2.7.11.1	R-HSA-202433 R-HSA-202433 Reactome Name: Generation of second messenger molecules See in Reactome R-HSA-376172 R-HSA-376172 Reactome Name: DSCAM interactions See in Reactome R-HSA-428540 R-HSA-428540 Reactome Name: Activation of RAC1 See in Reactome R-HSA-399954 R-HSA-399954 Reactome Name: Sema3A PAK dependent Axon repulsion See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome R-HSA-9013424 R-HSA-9013424 Reactome Name: RHOV GTPase cycle See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-389359 R-HSA-389359 Reactome Name: CD28 dependent Vav1 pathway See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-9013148 R-HSA-9013148 Reactome Name: CDC42 GTPase cycle See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-9013409 R-HSA-9013409 Reactome Name: RHOJ GTPase cycle See in Reactome R-HSA-9013406 R-HSA-9013406 Reactome Name: RHOQ GTPase cycle See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-445355 R-HSA-445355 Reactome Name: Smooth Muscle Contraction See in Reactome R-HSA-8964616 R-HSA-8964616 Reactome Name: G beta:gamma signalling through CDC42 See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Muscle contraction Immune System Developmental Biology Signal Transduction	R-HSA-2029454 ( R-HSA-2029482 ) R-HSA-2029454 Reaction Name: Autophosphorylation of PAK1 See in Reactome R-HSA-2029456 ( R-HSA-2029482; R-HSA-5627123 ) R-HSA-2029456 Reaction Name: RAC1 and CDC42 activate PAK1 See in Reactome R-HSA-2029460 ( R-HSA-2029482; R-HSA-5627123 ) R-HSA-2029460 Reaction Name: PAK1 phosphorylates LIMK1 See in Reactome R-HSA-2730856 ( R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730887 ( R-HSA-2871796 ) R-HSA-2730887 Reaction Name: Autophosphorylation and activation of MEKK1 See in Reactome R-HSA-2730889 ( R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-376123 ( R-HSA-376172 ) R-HSA-376123 Reaction Name: DSCAM associates with Rac1-GTP:pPAK1 See in Reactome R-HSA-389788 ( R-HSA-389359; R-HSA-5687128 ) R-HSA-389788 Reaction Name: Activation of PAKs by RAC1 and CDC42 See in Reactome R-HSA-3928619 ( R-HSA-3928662 ) R-HSA-3928619 Reaction Name: PAK1 binds RAC1:GTP See in Reactome R-HSA-3928620 ( R-HSA-3928662 ) R-HSA-3928620 Reaction Name: PAK1 autophosphorylates See in Reactome R-HSA-3928625 ( R-HSA-3928664 ) R-HSA-3928625 Reaction Name: PAKs autophosphorylate See in Reactome R-HSA-3928640 ( R-HSA-3928664 ) R-HSA-3928640 Reaction Name: PAKs phosphorylate MLC See in Reactome R-HSA-3928641 ( R-HSA-3928664 ) R-HSA-3928641 Reaction Name: PAK binds RAC and bPIX See in Reactome R-HSA-399930 ( R-HSA-399954 ) R-HSA-399930 Reaction Name: Activation of PAK by Rac1 See in Reactome R-HSA-399939 ( R-HSA-399954 ) R-HSA-399939 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-399952 ( R-HSA-399954 ) R-HSA-399952 Reaction Name: Phosphorylation of LIMK-1 by PAK See in Reactome R-HSA-419232 ( R-HSA-5625740; R-HSA-5627117; R-HSA-5627123 ) R-HSA-419232 Reaction Name: Myosin phosphatase dephosphorylates myosin regulatory light chain See in Reactome R-HSA-428531 ( R-HSA-428540 ) R-HSA-428531 Reaction Name: Recruitment of PAK to NCK See in Reactome R-HSA-430183 ( R-HSA-202433 ) R-HSA-430183 Reaction Name: NCK binds PAK See in Reactome R-HSA-442832 ( R-HSA-5627123 ) R-HSA-442832 Reaction Name: PAK phosphorylates cortactin See in Reactome R-HSA-445072 ( R-HSA-445144 ) R-HSA-445072 Reaction Name: Interaction of PAK1 with Rac1-GTP See in Reactome R-HSA-445797 ( R-HSA-445355; R-HSA-5627123 ) R-HSA-445797 Reaction Name: MYLK (MLCK) Active Calmodulin Binding See in Reactome R-HSA-451347 ( R-HSA-376172 ) R-HSA-451347 Reaction Name: Activation of JNK by DSCAM See in Reactome R-HSA-451366 ( R-HSA-376172 ) R-HSA-451366 Reaction Name: Activation of p38MAPK by DSCAM See in Reactome R-HSA-5357445 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357445 Reaction Name: PAK1-3 dimer disassociates See in Reactome R-HSA-5357472 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357472 Reaction Name: PAK1-3 autophosphorylates See in Reactome R-HSA-5357477 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357477 Reaction Name: PAK1-3 phosphorylates VE-cadherin See in Reactome R-HSA-5357483 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357483 Reaction Name: RAC1 binds PAK1-3 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5627775 ( R-HSA-5627123; R-HSA-5687128 ) R-HSA-5627775 Reaction Name: Autophosphorylation of PAK1,2,3 See in Reactome R-HSA-5668947 ( R-HSA-5627123 ) R-HSA-5668947 Reaction Name: PAK1 phosphorylates myosin phosphatase See in Reactome R-HSA-5668984 ( R-HSA-5627123 ) R-HSA-5668984 Reaction Name: PAK1 or PAK2 phosphorylates MYLK See in Reactome R-HSA-5669158 ( R-HSA-5627123 ) R-HSA-5669158 Reaction Name: NF2 binds PAK1 See in Reactome R-HSA-5669240 ( R-HSA-5627123 ) R-HSA-5669240 Reaction Name: FLNA binds PAK1 See in Reactome R-HSA-5669250 ( R-HSA-5627123 ) R-HSA-5669250 Reaction Name: PAK1 phosphorylates FLNA See in Reactome R-HSA-5687086 ( R-HSA-5687128 ) R-HSA-5687086 Reaction Name: PAK1,2,3 phosphorylates MAPK6,4 See in Reactome R-HSA-8964599 ( R-HSA-8964616 ) R-HSA-8964599 Reaction Name: Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex See in Reactome R-HSA-8964604 ( R-HSA-8964616 ) R-HSA-8964604 Reaction Name: CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated See in Reactome R-HSA-8964605 ( R-HSA-8964616 ) R-HSA-8964605 Reaction Name: PAK1:ARHGEF6 complex binds G-protein beta-gamma complex See in Reactome R-HSA-8964614 ( R-HSA-8964616 ) R-HSA-8964614 Reaction Name: PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated See in Reactome R-HSA-8964619 ( R-HSA-8964616 ) R-HSA-8964619 Reaction Name: PAK1 binds ARHGEF6 See in Reactome R-HSA-8964634 ( R-HSA-8964616 ) R-HSA-8964634 Reaction Name: CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9013157 ( R-HSA-9013148 ) R-HSA-9013157 Reaction Name: CDC42 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9017507 ( R-HSA-9013409 ) R-HSA-9017507 Reaction Name: RHOJ binds effectors at the plasma membrane See in Reactome R-HSA-9018746 ( R-HSA-9013406 ) R-HSA-9018746 Reaction Name: RHOQ binds effectors at the plasma membrane See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome R-HSA-9018766 ( R-HSA-9013420 ) R-HSA-9018766 Reaction Name: RHOU binds effectors at the plasma membrane See in Reactome R-HSA-9018794 ( R-HSA-9013424 ) R-HSA-9018794 Reaction Name: RHOV binds effectors at the plasma membrane See in Reactome R-HSA-9018808 ( R-HSA-9013423 ) R-HSA-9018808 Reaction Name: RAC3 binds effectors at the plasma membrane See in Reactome
MONDO:0033669	MAPK1	P28482	2.7.11.24	R-HSA-2559585 R-HSA-2559585 Reactome Name: Oncogene Induced Senescence See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-111995 R-HSA-111995 Reactome Name: phospho-PLA2 pathway See in Reactome R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-198753 R-HSA-198753 Reactome Name: ERK/MAPK targets See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-444257 R-HSA-444257 Reactome Name: RSK activation See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-1181150 R-HSA-1181150 Reactome Name: Signaling by NODAL See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-2173796 R-HSA-2173796 Reactome Name: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-1502540 R-HSA-1502540 Reactome Name: Signaling by Activin See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-450341 R-HSA-450341 Reactome Name: Activation of the AP-1 family of transcription factors See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-74749 R-HSA-74749 Reactome Name: Signal attenuation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-202670 R-HSA-202670 Reactome Name: ERKs are inactivated See in Reactome R-HSA-879415 R-HSA-879415 Reactome Name: Advanced glycosylation endproduct receptor signaling See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-162658 R-HSA-162658 Reactome Name: Golgi Cisternae Pericentriolar Stack Reorganization See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-9627069 R-HSA-9627069 Reactome Name: Regulation of the apoptosome activity See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-3371453 R-HSA-3371453 Reactome Name: Regulation of HSF1-mediated heat shock response See in Reactome	R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-111471 R-HSA-111471 Reactome Name: Apoptotic factor-mediated response See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-450282 R-HSA-450282 Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-111461 R-HSA-111461 Reactome Name: Cytochrome c-mediated apoptotic response See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-68875 R-HSA-68875 Reactome Name: Mitotic Prophase See in Reactome R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-2173793 R-HSA-2173793 Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-111458 R-HSA-111458 Reactome Name: Formation of apoptosome See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Developmental Biology Neuronal System Immune System Programmed Cell Death Gene expression (Transcription) Cellular responses to stimuli Hemostasis Signal Transduction	R-HSA-109822 ( R-HSA-74749 ) R-HSA-109822 Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 See in Reactome R-HSA-109823 ( R-HSA-74749 ) R-HSA-109823 Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 See in Reactome R-HSA-109858 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-109862 ( R-HSA-112409; R-HSA-112411; R-HSA-445144 ) R-HSA-109862 Reaction Name: MAP2K2 phosphorylates MAPK1 See in Reactome R-HSA-109864 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109864 Reaction Name: Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 See in Reactome R-HSA-111898 ( R-HSA-111995 ) R-HSA-111898 Reaction Name: Phosphorylation of cPLA2 by ERK-2 See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-1295634 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-168053 ( R-HSA-450341 ) R-HSA-168053 Reaction Name: Phosphorylated MAPKs phosphorylate ATF-2 See in Reactome R-HSA-173488 ( R-HSA-1181150; R-HSA-1502540; R-HSA-2173796 ) R-HSA-173488 Reaction Name: The SMAD2/3:SMAD4 complex transfers to the nucleus See in Reactome R-HSA-198731 ( R-HSA-198753; R-HSA-8939211; R-HSA-9634638 ) R-HSA-198731 Reaction Name: ERK1/2 activates ELK1 See in Reactome R-HSA-198746 ( R-HSA-198753; R-HSA-2559582; R-HSA-881907 ) R-HSA-198746 Reaction Name: ERK1/2/5 activate RSK1/2/3 See in Reactome R-HSA-198756 ( R-HSA-198753; R-HSA-375165 ) R-HSA-198756 Reaction Name: ERK1/2 phosphorylates MSK1 See in Reactome R-HSA-199959 ( R-HSA-198753; R-HSA-202670 ) R-HSA-199959 Reaction Name: ERKs are inactivated by protein phosphatase 2A See in Reactome R-HSA-2029469 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029469 Reaction Name: p-ERK phosphorylates WAVEs and ABI See in Reactome R-HSA-203797 ( R-HSA-198753; R-HSA-202670 ) R-HSA-203797 Reaction Name: ERKs are inactivated by dual-specific phosphatases (DUSPs) See in Reactome R-HSA-2422927 ( R-HSA-162658 ) R-HSA-2422927 Reaction Name: MAPK3-3 or MAPK1 phosphorylate GORASP2 See in Reactome R-HSA-3132737 ( R-HSA-2559585 ) R-HSA-3132737 Reaction Name: MAPKs phosphorylate ETS1 and ETS2 See in Reactome R-HSA-3209160 ( R-HSA-2559585 ) R-HSA-3209160 Reaction Name: Activated ERKs phosphorylate ERF See in Reactome R-HSA-3209177 ( R-HSA-2559585 ) R-HSA-3209177 Reaction Name: ERF binds ETS2 promoter See in Reactome R-HSA-3223236 ( R-HSA-2559580 ) R-HSA-3223236 Reaction Name: RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS) See in Reactome R-HSA-3371531 ( R-HSA-3371453 ) R-HSA-3371531 Reaction Name: Constitutive phosphorylation by pERK1/2 See in Reactome R-HSA-3857329 ( R-HSA-2559582 ) R-HSA-3857329 Reaction Name: MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB See in Reactome R-HSA-418158 ( R-HSA-456926 ) R-HSA-418158 Reaction Name: SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) See in Reactome R-HSA-418163 ( R-HSA-456926 ) R-HSA-418163 Reaction Name: Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) See in Reactome R-HSA-418170 ( R-HSA-456926 ) R-HSA-418170 Reaction Name: F2R:ARRB1 binds MAPKs, SRC-1 See in Reactome R-HSA-418176 ( R-HSA-456926 ) R-HSA-418176 Reaction Name: F2R:ARRB2 binds MAPKs, SRC-1 See in Reactome R-HSA-418200 ( R-HSA-456926 ) R-HSA-418200 Reaction Name: SRC-1 bound to ARRB2 is not activated See in Reactome R-HSA-445079 ( R-HSA-437239 ) R-HSA-445079 Reaction Name: Phosphorylation of L1 by ERK See in Reactome R-HSA-450325 ( R-HSA-2559580; R-HSA-2871796; R-HSA-450341 ) R-HSA-450325 Reaction Name: c-FOS activation by phospho ERK1/2 See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654562 ( R-HSA-5654727 ) R-HSA-5654562 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 See in Reactome R-HSA-5654565 ( R-HSA-5654732 ) R-HSA-5654565 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. See in Reactome R-HSA-5654566 ( R-HSA-5654733 ) R-HSA-5654566 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674366 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674366 Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs See in Reactome R-HSA-5674373 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674373 Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane See in Reactome R-HSA-5674385 ( R-HSA-112409; R-HSA-170968; R-HSA-5673001 ) R-HSA-5674385 Reaction Name: p-T,Y MAPKs dimerize See in Reactome R-HSA-5674387 ( R-HSA-112409; R-HSA-5673001 ) R-HSA-5674387 Reaction Name: Phosphorylated MAPKs translocate into the nucleus See in Reactome R-HSA-5674496 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5674496 Reaction Name: Activated MAPKs phosphorylate MAP2K1 See in Reactome R-HSA-5675194 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675194 Reaction Name: Activated MAPK phosphorylates RAF1 See in Reactome R-HSA-5675198 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675206 ( R-HSA-112409; R-HSA-5673001 ) R-HSA-5675206 Reaction Name: PEA15 binds MAPK monomers and dimers See in Reactome R-HSA-5675373 ( R-HSA-112409; R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675373 Reaction Name: Nuclear DUSPs dephosphorylate MAPKs See in Reactome R-HSA-5675376 ( R-HSA-112409; R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675376 Reaction Name: Cytosolic DUSPs dephosphorylate MAPKs See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-6811454 ( R-HSA-6811558 ) R-HSA-6811454 Reaction Name: MAPKs phosphorylate PP2A See in Reactome R-HSA-6811472 ( R-HSA-6811558 ) R-HSA-6811472 Reaction Name: IER3 recruits MAPKs to PP2A-B56-beta,gamma See in Reactome R-HSA-879362 ( R-HSA-879415 ) R-HSA-879362 Reaction Name: AGER binds ERK1/2 See in Reactome R-HSA-8944047 ( R-HSA-8943724 ) R-HSA-8944047 Reaction Name: JUN binds the PTEN gene promoter See in Reactome R-HSA-9009208 ( R-HSA-8940973 ) R-HSA-9009208 Reaction Name: Activated ERKs phosphorylate RUNX2 See in Reactome R-HSA-9032751 ( R-HSA-8939211 ) R-HSA-9032751 Reaction Name: Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610166 ( R-HSA-170968 ) R-HSA-9610166 Reaction Name: p-T,Y MAPK dimers translocate to nucleus See in Reactome R-HSA-9619843 ( R-HSA-444257 ) R-HSA-9619843 Reaction Name: ERKs phosphorylate RSKs See in Reactome R-HSA-9626832 ( R-HSA-5668599 ) R-HSA-9626832 Reaction Name: MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 See in Reactome R-HSA-9627089 ( R-HSA-9627069 ) R-HSA-9627089 Reaction Name: CASP9 is phosphorylated at T125 See in Reactome R-HSA-9632873 ( R-HSA-8939211; R-HSA-9634638 ) R-HSA-9632873 Reaction Name: p-S10 CDKN1B translocates to the cytosol See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9635739 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-9635739 Reaction Name: PTPN7 dephosphorylates p-T,Y-MAPKs See in Reactome R-HSA-9635743 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-9635743 Reaction Name: PTPN7 binds p-T,Y-MAPK See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome

Number of enzymes:	8
Number of disease:	40
Number of reactomes:	134
Number of reactions:	355

Search summary (Reactome ID: R-HSA-445144)

Search results (Reactome ID: R-HSA-445144)

MONDO:0002529

R-HSA-376172

R-HSA-445144

R-HSA-418885

R-HSA-9619229

R-HSA-428540

R-HSA-428543

R-HSA-114604

R-HSA-399954

R-HSA-9032845

R-HSA-8849471

R-HSA-5663213

R-HSA-6798695

R-HSA-983231

R-HSA-193648

R-HSA-5625900

R-HSA-5625740

R-HSA-9032759

R-HSA-1257604

R-HSA-2871796

R-HSA-389359

R-HSA-5627123

R-HSA-399955

R-HSA-5626467

R-HSA-4420097

R-HSA-5663220

R-HSA-2029482

R-HSA-5687128

R-HSA-6811558

R-HSA-1433557

R-HSA-1445148

R-HSA-2424491

R-HSA-9013149

R-HSA-5668599

R-HSA-8875555

R-HSA-3928665

R-HSA-3928664

R-HSA-416550

R-HSA-4086400

R-HSA-3928662

R-HSA-5625970

R-HSA-5218920

R-HSA-376176

R-HSA-9012999

R-HSA-168256

R-HSA-194315

R-HSA-9006927

R-HSA-9006925

R-HSA-193704

R-HSA-438064

R-HSA-8848021

R-HSA-1280218

R-HSA-1266738

R-HSA-400685

R-HSA-166520

R-HSA-194138

R-HSA-76002

R-HSA-388841

R-HSA-9675108

R-HSA-199418

R-HSA-389356

R-HSA-112316

R-HSA-8875878

R-HSA-112315

R-HSA-373760

R-HSA-9032500

R-HSA-2454202

R-HSA-3858494

R-HSA-2029480

R-HSA-168249

R-HSA-195258

R-HSA-199991

R-HSA-73887

R-HSA-9006934

R-HSA-9006115

R-HSA-442755

R-HSA-2682334

R-HSA-112314