DAR - Bologna Biocomputing Group

Search results (Reactome ID: R-HSA-442982)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0001187	HRAS	P01112	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-4093331 ( R-HSA-3928662 ) R-HSA-4093331 Reaction Name: Ras:GTP binds p120-RasGAP See in Reactome R-HSA-4093339 ( R-HSA-3928662 ) R-HSA-4093339 Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9660557 ( R-HSA-5673001 ) R-HSA-9660557 Reaction Name: RAS:GTP binds RAL GDS proteins See in Reactome
MONDO:0001187	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0005012	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0005233	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0005335	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0005575	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0007154	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0007256	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0007265	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0007648	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0008093	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0008097	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0008097	HRAS	P01112	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-4093331 ( R-HSA-3928662 ) R-HSA-4093331 Reaction Name: Ras:GTP binds p120-RasGAP See in Reactome R-HSA-4093339 ( R-HSA-3928662 ) R-HSA-4093339 Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9660557 ( R-HSA-5673001 ) R-HSA-9660557 Reaction Name: RAS:GTP binds RAL GDS proteins See in Reactome
MONDO:0008097	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0008566	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0008566	HRAS	P01112	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-4093331 ( R-HSA-3928662 ) R-HSA-4093331 Reaction Name: Ras:GTP binds p120-RasGAP See in Reactome R-HSA-4093339 ( R-HSA-3928662 ) R-HSA-4093339 Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9660557 ( R-HSA-5673001 ) R-HSA-9660557 Reaction Name: RAS:GTP binds RAL GDS proteins See in Reactome
MONDO:0009026	HRAS	P01112	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-4093331 ( R-HSA-3928662 ) R-HSA-4093331 Reaction Name: Ras:GTP binds p120-RasGAP See in Reactome R-HSA-4093339 ( R-HSA-3928662 ) R-HSA-4093339 Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9660557 ( R-HSA-5673001 ) R-HSA-9660557 Reaction Name: RAS:GTP binds RAL GDS proteins See in Reactome
MONDO:0009578	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0009693	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0010854	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0011908	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0011908	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0012371	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0013186	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0013767	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0013767	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0014112	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0015278	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0015447	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0016419	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0016692	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0016982	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0017317	HRAS	P01112	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-4093331 ( R-HSA-3928662 ) R-HSA-4093331 Reaction Name: Ras:GTP binds p120-RasGAP See in Reactome R-HSA-4093339 ( R-HSA-3928662 ) R-HSA-4093339 Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9660557 ( R-HSA-5673001 ) R-HSA-9660557 Reaction Name: RAS:GTP binds RAL GDS proteins See in Reactome
MONDO:0018874	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0019086	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0019311	HRAS	P01112	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-4093331 ( R-HSA-3928662 ) R-HSA-4093331 Reaction Name: Ras:GTP binds p120-RasGAP See in Reactome R-HSA-4093339 ( R-HSA-3928662 ) R-HSA-4093339 Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9660557 ( R-HSA-5673001 ) R-HSA-9660557 Reaction Name: RAS:GTP binds RAL GDS proteins See in Reactome
MONDO:0019438	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0030919	CAMK2A	Q9UQM7	2.7.11.17	R-HSA-111932 R-HSA-111932 Reactome Name: CaMK IV-mediated phosphorylation of CREB See in Reactome R-HSA-9617324 R-HSA-9617324 Reactome Name: Negative regulation of NMDA receptor-mediated neuronal transmission See in Reactome R-HSA-5576892 R-HSA-5576892 Reactome Name: Phase 0 - rapid depolarisation See in Reactome R-HSA-9620244 R-HSA-9620244 Reactome Name: Long-term potentiation See in Reactome R-HSA-5578775 R-HSA-5578775 Reactome Name: Ion homeostasis See in Reactome R-HSA-9022692 R-HSA-9022692 Reactome Name: Regulation of MECP2 expression and activity See in Reactome R-HSA-399719 R-HSA-399719 Reactome Name: Trafficking of AMPA receptors See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-438066 R-HSA-438066 Reactome Name: Unblocking of NMDA receptors, glutamate binding and activation See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-936837 R-HSA-936837 Reactome Name: Ion transport by P-type ATPases See in Reactome R-HSA-9609736 R-HSA-9609736 Reactome Name: Assembly and cell surface presentation of NMDA receptors See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-983712 R-HSA-983712 Reactome Name: Ion channel transport See in Reactome R-HSA-5576891 R-HSA-5576891 Reactome Name: Cardiac conduction See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-399721 R-HSA-399721 Reactome Name: Glutamate binding, activation of AMPA receptors and synaptic plasticity See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Muscle contraction Immune System Transport of small molecules Gene expression (Transcription) Neuronal System Cellular responses to stimuli Signal Transduction	R-HSA-416320 ( R-HSA-399719 ) R-HSA-416320 Reaction Name: Trafficking of GluR1-containing AMPA receptors See in Reactome R-HSA-427910 ( R-HSA-5578775; R-HSA-936837 ) R-HSA-427910 Reaction Name: ATP2A1-3 transport Ca2+ from cytosol to ER lumen See in Reactome R-HSA-432162 ( R-HSA-438066 ) R-HSA-432162 Reaction Name: Unblocking of GRIN1:GRIN2 NMDA receptors See in Reactome R-HSA-432164 ( R-HSA-438066 ) R-HSA-432164 Reaction Name: Ca2+ influx into the post-synaptic cell See in Reactome R-HSA-432172 ( R-HSA-438066 ) R-HSA-432172 Reaction Name: Glycine and glutamate ligands bind GRIN1:GRIN2 NMDA receptor See in Reactome R-HSA-4332356 ( R-HSA-4086398 ) R-HSA-4332356 Reaction Name: CAMK2 binds MAP3K7 See in Reactome R-HSA-4332358 ( R-HSA-4086398 ) R-HSA-4332358 Reaction Name: Dissociation of CaM and CAMK2 autophosphorylation See in Reactome R-HSA-4332359 ( R-HSA-4086398 ) R-HSA-4332359 Reaction Name: Active calmodulin binds CAMK2 See in Reactome R-HSA-4332363 ( R-HSA-4086398 ) R-HSA-4332363 Reaction Name: Autophosphorylation and activation of CAMK2 See in Reactome R-HSA-4332388 ( R-HSA-4086398 ) R-HSA-4332388 Reaction Name: Activation of MAP3K7 in response to WNT See in Reactome R-HSA-438037 ( R-HSA-438066 ) R-HSA-438037 Reaction Name: Membrane depolarization upon activation of Ca impermeable AMPA receptors See in Reactome R-HSA-442725 ( R-HSA-111932; R-HSA-9620244 ) R-HSA-442725 Reaction Name: CaMKII binds activated calmodulin See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-442760 ( R-HSA-442982 ) R-HSA-442760 Reaction Name: Activation of RasGRF See in Reactome R-HSA-445367 ( R-HSA-9620244 ) R-HSA-445367 Reaction Name: CaMKII binds activated NMDA receptor See in Reactome R-HSA-5082387 ( R-HSA-3371571 ) R-HSA-5082387 Reaction Name: Phosphorylation of HSF1 at Ser230 induces transactivation See in Reactome R-HSA-5576895 ( R-HSA-5576892 ) R-HSA-5576895 Reaction Name: SCNAs:SNCBs transport Na+ from extracellular region to cytosol See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-9006992 ( R-HSA-9022692 ) R-HSA-9006992 Reaction Name: MECP2 is phosphorylated at S423 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-9611368 ( R-HSA-9609736 ) R-HSA-9611368 Reaction Name: CaMKII and LRRC7 bind to NMDA receptors at postsynaptic density See in Reactome R-HSA-9612085 ( R-HSA-9620244 ) R-HSA-9612085 Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs See in Reactome R-HSA-9614185 ( R-HSA-438066 ) R-HSA-9614185 Reaction Name: Mg2+ binds GRIN1:GRIN2 NMDA receptors See in Reactome R-HSA-9617326 ( R-HSA-9617324 ) R-HSA-9617326 Reaction Name: CALM1:4xCa2+ binds GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors and displaces ACTN2 See in Reactome R-HSA-9617583 ( R-HSA-111932; R-HSA-9620244 ) R-HSA-9617583 Reaction Name: CaMKII autophosphorylates See in Reactome R-HSA-9618750 ( R-HSA-9620244 ) R-HSA-9618750 Reaction Name: CaMKII phosphorylates AMPA receptor See in Reactome R-HSA-9619449 ( R-HSA-9617324 ) R-HSA-9619449 Reaction Name: PPM1F dephosphorylates p-T286-CaMKII See in Reactome
MONDO:0030920	CAMK2B	Q13554	2.7.11.17	R-HSA-442729 R-HSA-442729 Reactome Name: CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde See in Reactome R-HSA-111932 R-HSA-111932 Reactome Name: CaMK IV-mediated phosphorylation of CREB See in Reactome R-HSA-9617324 R-HSA-9617324 Reactome Name: Negative regulation of NMDA receptor-mediated neuronal transmission See in Reactome R-HSA-5576892 R-HSA-5576892 Reactome Name: Phase 0 - rapid depolarisation See in Reactome R-HSA-9620244 R-HSA-9620244 Reactome Name: Long-term potentiation See in Reactome R-HSA-5578775 R-HSA-5578775 Reactome Name: Ion homeostasis See in Reactome R-HSA-9022692 R-HSA-9022692 Reactome Name: Regulation of MECP2 expression and activity See in Reactome R-HSA-399719 R-HSA-399719 Reactome Name: Trafficking of AMPA receptors See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-438066 R-HSA-438066 Reactome Name: Unblocking of NMDA receptors, glutamate binding and activation See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-936837 R-HSA-936837 Reactome Name: Ion transport by P-type ATPases See in Reactome R-HSA-9609736 R-HSA-9609736 Reactome Name: Assembly and cell surface presentation of NMDA receptors See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5576891 R-HSA-5576891 Reactome Name: Cardiac conduction See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-983712 R-HSA-983712 Reactome Name: Ion channel transport See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-399721 R-HSA-399721 Reactome Name: Glutamate binding, activation of AMPA receptors and synaptic plasticity See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Muscle contraction Immune System Transport of small molecules Gene expression (Transcription) Neuronal System Cellular responses to stimuli Signal Transduction	R-HSA-416320 ( R-HSA-399719 ) R-HSA-416320 Reaction Name: Trafficking of GluR1-containing AMPA receptors See in Reactome R-HSA-427910 ( R-HSA-5578775; R-HSA-936837 ) R-HSA-427910 Reaction Name: ATP2A1-3 transport Ca2+ from cytosol to ER lumen See in Reactome R-HSA-432162 ( R-HSA-438066 ) R-HSA-432162 Reaction Name: Unblocking of GRIN1:GRIN2 NMDA receptors See in Reactome R-HSA-432164 ( R-HSA-438066 ) R-HSA-432164 Reaction Name: Ca2+ influx into the post-synaptic cell See in Reactome R-HSA-432172 ( R-HSA-438066 ) R-HSA-432172 Reaction Name: Glycine and glutamate ligands bind GRIN1:GRIN2 NMDA receptor See in Reactome R-HSA-438037 ( R-HSA-438066 ) R-HSA-438037 Reaction Name: Membrane depolarization upon activation of Ca impermeable AMPA receptors See in Reactome R-HSA-442725 ( R-HSA-111932; R-HSA-9620244 ) R-HSA-442725 Reaction Name: CaMKII binds activated calmodulin See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-442760 ( R-HSA-442982 ) R-HSA-442760 Reaction Name: Activation of RasGRF See in Reactome R-HSA-444792 ( R-HSA-111932; R-HSA-442729 ) R-HSA-444792 Reaction Name: Calmodulin-bound CaMKII-gamma enters the nucleus See in Reactome R-HSA-445367 ( R-HSA-9620244 ) R-HSA-445367 Reaction Name: CaMKII binds activated NMDA receptor See in Reactome R-HSA-5082387 ( R-HSA-3371571 ) R-HSA-5082387 Reaction Name: Phosphorylation of HSF1 at Ser230 induces transactivation See in Reactome R-HSA-5576895 ( R-HSA-5576892 ) R-HSA-5576895 Reaction Name: SCNAs:SNCBs transport Na+ from extracellular region to cytosol See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-9006992 ( R-HSA-9022692 ) R-HSA-9006992 Reaction Name: MECP2 is phosphorylated at S423 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-9611368 ( R-HSA-9609736 ) R-HSA-9611368 Reaction Name: CaMKII and LRRC7 bind to NMDA receptors at postsynaptic density See in Reactome R-HSA-9612085 ( R-HSA-9620244 ) R-HSA-9612085 Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs See in Reactome R-HSA-9614185 ( R-HSA-438066 ) R-HSA-9614185 Reaction Name: Mg2+ binds GRIN1:GRIN2 NMDA receptors See in Reactome R-HSA-9617326 ( R-HSA-9617324 ) R-HSA-9617326 Reaction Name: CALM1:4xCa2+ binds GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors and displaces ACTN2 See in Reactome R-HSA-9617583 ( R-HSA-111932; R-HSA-9620244 ) R-HSA-9617583 Reaction Name: CaMKII autophosphorylates See in Reactome R-HSA-9618750 ( R-HSA-9620244 ) R-HSA-9618750 Reaction Name: CaMKII phosphorylates AMPA receptor See in Reactome R-HSA-9619449 ( R-HSA-9617324 ) R-HSA-9619449 Reaction Name: PPM1F dephosphorylates p-T286-CaMKII See in Reactome
MONDO:0032795	CAMK2G	Q13555	2.7.11.17	R-HSA-442729 R-HSA-442729 Reactome Name: CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde See in Reactome R-HSA-111932 R-HSA-111932 Reactome Name: CaMK IV-mediated phosphorylation of CREB See in Reactome R-HSA-9617324 R-HSA-9617324 Reactome Name: Negative regulation of NMDA receptor-mediated neuronal transmission See in Reactome R-HSA-5576892 R-HSA-5576892 Reactome Name: Phase 0 - rapid depolarisation See in Reactome R-HSA-9620244 R-HSA-9620244 Reactome Name: Long-term potentiation See in Reactome R-HSA-5578775 R-HSA-5578775 Reactome Name: Ion homeostasis See in Reactome R-HSA-9022692 R-HSA-9022692 Reactome Name: Regulation of MECP2 expression and activity See in Reactome R-HSA-399719 R-HSA-399719 Reactome Name: Trafficking of AMPA receptors See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-438066 R-HSA-438066 Reactome Name: Unblocking of NMDA receptors, glutamate binding and activation See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-936837 R-HSA-936837 Reactome Name: Ion transport by P-type ATPases See in Reactome R-HSA-9609736 R-HSA-9609736 Reactome Name: Assembly and cell surface presentation of NMDA receptors See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5576891 R-HSA-5576891 Reactome Name: Cardiac conduction See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-983712 R-HSA-983712 Reactome Name: Ion channel transport See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-399721 R-HSA-399721 Reactome Name: Glutamate binding, activation of AMPA receptors and synaptic plasticity See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Muscle contraction Immune System Transport of small molecules Gene expression (Transcription) Neuronal System Cellular responses to stimuli Signal Transduction	R-HSA-416320 ( R-HSA-399719 ) R-HSA-416320 Reaction Name: Trafficking of GluR1-containing AMPA receptors See in Reactome R-HSA-427910 ( R-HSA-5578775; R-HSA-936837 ) R-HSA-427910 Reaction Name: ATP2A1-3 transport Ca2+ from cytosol to ER lumen See in Reactome R-HSA-432162 ( R-HSA-438066 ) R-HSA-432162 Reaction Name: Unblocking of GRIN1:GRIN2 NMDA receptors See in Reactome R-HSA-432164 ( R-HSA-438066 ) R-HSA-432164 Reaction Name: Ca2+ influx into the post-synaptic cell See in Reactome R-HSA-432172 ( R-HSA-438066 ) R-HSA-432172 Reaction Name: Glycine and glutamate ligands bind GRIN1:GRIN2 NMDA receptor See in Reactome R-HSA-438037 ( R-HSA-438066 ) R-HSA-438037 Reaction Name: Membrane depolarization upon activation of Ca impermeable AMPA receptors See in Reactome R-HSA-442725 ( R-HSA-111932; R-HSA-9620244 ) R-HSA-442725 Reaction Name: CaMKII binds activated calmodulin See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-442760 ( R-HSA-442982 ) R-HSA-442760 Reaction Name: Activation of RasGRF See in Reactome R-HSA-444792 ( R-HSA-111932; R-HSA-442729 ) R-HSA-444792 Reaction Name: Calmodulin-bound CaMKII-gamma enters the nucleus See in Reactome R-HSA-445367 ( R-HSA-9620244 ) R-HSA-445367 Reaction Name: CaMKII binds activated NMDA receptor See in Reactome R-HSA-5082387 ( R-HSA-3371571 ) R-HSA-5082387 Reaction Name: Phosphorylation of HSF1 at Ser230 induces transactivation See in Reactome R-HSA-5576895 ( R-HSA-5576892 ) R-HSA-5576895 Reaction Name: SCNAs:SNCBs transport Na+ from extracellular region to cytosol See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-9006992 ( R-HSA-9022692 ) R-HSA-9006992 Reaction Name: MECP2 is phosphorylated at S423 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-9611368 ( R-HSA-9609736 ) R-HSA-9611368 Reaction Name: CaMKII and LRRC7 bind to NMDA receptors at postsynaptic density See in Reactome R-HSA-9612085 ( R-HSA-9620244 ) R-HSA-9612085 Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs See in Reactome R-HSA-9614185 ( R-HSA-438066 ) R-HSA-9614185 Reaction Name: Mg2+ binds GRIN1:GRIN2 NMDA receptors See in Reactome R-HSA-9617326 ( R-HSA-9617324 ) R-HSA-9617326 Reaction Name: CALM1:4xCa2+ binds GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors and displaces ACTN2 See in Reactome R-HSA-9617583 ( R-HSA-111932; R-HSA-9620244 ) R-HSA-9617583 Reaction Name: CaMKII autophosphorylates See in Reactome R-HSA-9618750 ( R-HSA-9620244 ) R-HSA-9618750 Reaction Name: CaMKII phosphorylates AMPA receptor See in Reactome R-HSA-9618834 ( R-HSA-111932; R-HSA-442729 ) R-HSA-9618834 Reaction Name: Activated calmodulin dissociates from CaMKII-gamma See in Reactome R-HSA-9619449 ( R-HSA-9617324 ) R-HSA-9619449 Reaction Name: PPM1F dephosphorylates p-T286-CaMKII See in Reactome
MONDO:0044792	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0044792	HRAS	P01112	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-4093331 ( R-HSA-3928662 ) R-HSA-4093331 Reaction Name: Ras:GTP binds p120-RasGAP See in Reactome R-HSA-4093339 ( R-HSA-3928662 ) R-HSA-4093339 Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9660557 ( R-HSA-5673001 ) R-HSA-9660557 Reaction Name: RAS:GTP binds RAL GDS proteins See in Reactome
MONDO:0054861	CAMK2A	Q9UQM7	2.7.11.17	R-HSA-111932 R-HSA-111932 Reactome Name: CaMK IV-mediated phosphorylation of CREB See in Reactome R-HSA-9617324 R-HSA-9617324 Reactome Name: Negative regulation of NMDA receptor-mediated neuronal transmission See in Reactome R-HSA-5576892 R-HSA-5576892 Reactome Name: Phase 0 - rapid depolarisation See in Reactome R-HSA-9620244 R-HSA-9620244 Reactome Name: Long-term potentiation See in Reactome R-HSA-5578775 R-HSA-5578775 Reactome Name: Ion homeostasis See in Reactome R-HSA-9022692 R-HSA-9022692 Reactome Name: Regulation of MECP2 expression and activity See in Reactome R-HSA-399719 R-HSA-399719 Reactome Name: Trafficking of AMPA receptors See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-438066 R-HSA-438066 Reactome Name: Unblocking of NMDA receptors, glutamate binding and activation See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-936837 R-HSA-936837 Reactome Name: Ion transport by P-type ATPases See in Reactome R-HSA-9609736 R-HSA-9609736 Reactome Name: Assembly and cell surface presentation of NMDA receptors See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-983712 R-HSA-983712 Reactome Name: Ion channel transport See in Reactome R-HSA-5576891 R-HSA-5576891 Reactome Name: Cardiac conduction See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-399721 R-HSA-399721 Reactome Name: Glutamate binding, activation of AMPA receptors and synaptic plasticity See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Muscle contraction Immune System Transport of small molecules Gene expression (Transcription) Neuronal System Cellular responses to stimuli Signal Transduction	R-HSA-416320 ( R-HSA-399719 ) R-HSA-416320 Reaction Name: Trafficking of GluR1-containing AMPA receptors See in Reactome R-HSA-427910 ( R-HSA-5578775; R-HSA-936837 ) R-HSA-427910 Reaction Name: ATP2A1-3 transport Ca2+ from cytosol to ER lumen See in Reactome R-HSA-432162 ( R-HSA-438066 ) R-HSA-432162 Reaction Name: Unblocking of GRIN1:GRIN2 NMDA receptors See in Reactome R-HSA-432164 ( R-HSA-438066 ) R-HSA-432164 Reaction Name: Ca2+ influx into the post-synaptic cell See in Reactome R-HSA-432172 ( R-HSA-438066 ) R-HSA-432172 Reaction Name: Glycine and glutamate ligands bind GRIN1:GRIN2 NMDA receptor See in Reactome R-HSA-4332356 ( R-HSA-4086398 ) R-HSA-4332356 Reaction Name: CAMK2 binds MAP3K7 See in Reactome R-HSA-4332358 ( R-HSA-4086398 ) R-HSA-4332358 Reaction Name: Dissociation of CaM and CAMK2 autophosphorylation See in Reactome R-HSA-4332359 ( R-HSA-4086398 ) R-HSA-4332359 Reaction Name: Active calmodulin binds CAMK2 See in Reactome R-HSA-4332363 ( R-HSA-4086398 ) R-HSA-4332363 Reaction Name: Autophosphorylation and activation of CAMK2 See in Reactome R-HSA-4332388 ( R-HSA-4086398 ) R-HSA-4332388 Reaction Name: Activation of MAP3K7 in response to WNT See in Reactome R-HSA-438037 ( R-HSA-438066 ) R-HSA-438037 Reaction Name: Membrane depolarization upon activation of Ca impermeable AMPA receptors See in Reactome R-HSA-442725 ( R-HSA-111932; R-HSA-9620244 ) R-HSA-442725 Reaction Name: CaMKII binds activated calmodulin See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-442760 ( R-HSA-442982 ) R-HSA-442760 Reaction Name: Activation of RasGRF See in Reactome R-HSA-445367 ( R-HSA-9620244 ) R-HSA-445367 Reaction Name: CaMKII binds activated NMDA receptor See in Reactome R-HSA-5082387 ( R-HSA-3371571 ) R-HSA-5082387 Reaction Name: Phosphorylation of HSF1 at Ser230 induces transactivation See in Reactome R-HSA-5576895 ( R-HSA-5576892 ) R-HSA-5576895 Reaction Name: SCNAs:SNCBs transport Na+ from extracellular region to cytosol See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-9006992 ( R-HSA-9022692 ) R-HSA-9006992 Reaction Name: MECP2 is phosphorylated at S423 See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-9611368 ( R-HSA-9609736 ) R-HSA-9611368 Reaction Name: CaMKII and LRRC7 bind to NMDA receptors at postsynaptic density See in Reactome R-HSA-9612085 ( R-HSA-9620244 ) R-HSA-9612085 Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs See in Reactome R-HSA-9614185 ( R-HSA-438066 ) R-HSA-9614185 Reaction Name: Mg2+ binds GRIN1:GRIN2 NMDA receptors See in Reactome R-HSA-9617326 ( R-HSA-9617324 ) R-HSA-9617326 Reaction Name: CALM1:4xCa2+ binds GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors and displaces ACTN2 See in Reactome R-HSA-9617583 ( R-HSA-111932; R-HSA-9620244 ) R-HSA-9617583 Reaction Name: CaMKII autophosphorylates See in Reactome R-HSA-9618750 ( R-HSA-9620244 ) R-HSA-9618750 Reaction Name: CaMKII phosphorylates AMPA receptor See in Reactome R-HSA-9619449 ( R-HSA-9617324 ) R-HSA-9619449 Reaction Name: PPM1F dephosphorylates p-T286-CaMKII See in Reactome

Number of enzymes:	6
Number of disease:	36
Number of reactomes:	61
Number of reactions:	113

Search summary (Reactome ID: R-HSA-442982)

Search results (Reactome ID: R-HSA-442982)

MONDO:0001187

R-HSA-171007

R-HSA-2871796

R-HSA-9634635

R-HSA-1963640

R-HSA-5674135

R-HSA-9027284

R-HSA-9607240

R-HSA-8849471

R-HSA-186763

R-HSA-442982

R-HSA-5673000

R-HSA-5673001

R-HSA-9648002

R-HSA-9026519

R-HSA-5654688

R-HSA-9028731

R-HSA-5654700

R-HSA-5654712

R-HSA-5654706

R-HSA-5654704

R-HSA-1169092

R-HSA-74751

R-HSA-9034864

R-HSA-1433557

R-HSA-375165

R-HSA-167044

R-HSA-2428933

R-HSA-2424491

R-HSA-180336

R-HSA-5654693

R-HSA-5675221

R-HSA-5658442

R-HSA-179812

R-HSA-1250347

R-HSA-8851805

R-HSA-3928662

R-HSA-5621575

R-HSA-112412

R-HSA-210993

R-HSA-1250196

R-HSA-2179392

R-HSA-5654719

R-HSA-5218921

R-HSA-5654699

R-HSA-186797

R-HSA-8848021

R-HSA-2404192

R-HSA-168256

R-HSA-983705

R-HSA-202733

R-HSA-9006927

R-HSA-2428924

R-HSA-438064

R-HSA-2428928

R-HSA-1236394

R-HSA-112399

R-HSA-74752

R-HSA-442742

R-HSA-1266738

R-HSA-5654687

R-HSA-5683057

R-HSA-166520

R-HSA-194138

R-HSA-5684996

R-HSA-881907

R-HSA-9675108

R-HSA-177929

R-HSA-1168372

R-HSA-112316

R-HSA-5654708

R-HSA-112315

R-HSA-5654743

R-HSA-5654741

R-HSA-5621481

R-HSA-4420097

R-HSA-9006335

R-HSA-190236