DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-434313)

Number of enzymes:	2
Number of disease:	4
Number of reactomes:	13
Number of reactions:	31

Search results (Reactome ID: R-HSA-434313)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0010263	ACSL4	O60488	6.2.1.15 6.2.1.3	R-HSA-75876 R-HSA-75876 Reactome Name: Synthesis of very long-chain fatty acyl-CoAs See in Reactome R-HSA-434313 R-HSA-434313 Reactome Name: Intracellular metabolism of fatty acids regulates insulin secretion See in Reactome	R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome R-HSA-400451 R-HSA-400451 Reactome Name: Free fatty acids regulate insulin secretion See in Reactome R-HSA-75105 R-HSA-75105 Reactome Name: Fatty acyl-CoA biosynthesis See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome	Metabolism	R-HSA-434382 ( R-HSA-434313 ) R-HSA-434382 Reaction Name: ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell See in Reactome R-HSA-548843 ( R-HSA-75876 ) R-HSA-548843 Reaction Name: ACSL3,4 ligate CoA to AA to form AA-CoA See in Reactome
MONDO:0010313	ACSL4	O60488	6.2.1.15 6.2.1.3	R-HSA-75876 R-HSA-75876 Reactome Name: Synthesis of very long-chain fatty acyl-CoAs See in Reactome R-HSA-434313 R-HSA-434313 Reactome Name: Intracellular metabolism of fatty acids regulates insulin secretion See in Reactome	R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome R-HSA-400451 R-HSA-400451 Reactome Name: Free fatty acids regulate insulin secretion See in Reactome R-HSA-75105 R-HSA-75105 Reactome Name: Fatty acyl-CoA biosynthesis See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome	Metabolism	R-HSA-434382 ( R-HSA-434313 ) R-HSA-434382 Reaction Name: ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell See in Reactome R-HSA-548843 ( R-HSA-75876 ) R-HSA-548843 Reaction Name: ACSL3,4 ligate CoA to AA to form AA-CoA See in Reactome
MONDO:0012031	CD36	P16671	-	R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-434313 R-HSA-434313 Reactome Name: Intracellular metabolism of fatty acids regulates insulin secretion See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome R-HSA-1236973 R-HSA-1236973 Reactome Name: Cross-presentation of particulate exogenous antigens (phagosomes) See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-1236974 R-HSA-1236974 Reactome Name: ER-Phagosome pathway See in Reactome R-HSA-3000471 R-HSA-3000471 Reactome Name: Scavenging by Class B Receptors See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5686938 R-HSA-5686938 Reactome Name: Regulation of TLR by endogenous ligand See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-400451 R-HSA-400451 Reactome Name: Free fatty acids regulate insulin secretion See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-2173782 R-HSA-2173782 Reactome Name: Binding and Uptake of Ligands by Scavenger Receptors See in Reactome	Immune System Metabolism Developmental Biology Vesicle-mediated transport Hemostasis	R-HSA-1236956 ( R-HSA-1236973 ) R-HSA-1236956 Reaction Name: Engulfment of particulate antigen into phagocytic vesicle See in Reactome R-HSA-1236958 ( R-HSA-1236973 ) R-HSA-1236958 Reaction Name: Interaction of particulate antigens with dendritic cell receptors See in Reactome R-HSA-166072 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166072 Reaction Name: MyD88 forms a complex with TIRAP:activated TLR2/4 See in Reactome R-HSA-166082 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166082 Reaction Name: IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex See in Reactome R-HSA-166091 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166091 Reaction Name: IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex See in Reactome R-HSA-166119 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166119 Reaction Name: First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal See in Reactome R-HSA-166284 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166284 Reaction Name: Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP See in Reactome R-HSA-166286 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166286 Reaction Name: Multiple IRAK1 autophosphorylation steps See in Reactome R-HSA-166362 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166362 Reaction Name: Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-166363 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166363 Reaction Name: TRAF6 binds to hp- IRAK1 See in Reactome R-HSA-168950 ( R-HSA-168188 ) R-HSA-168950 Reaction Name: TLR6:TLR2 is recruited to ligand:CD14:CD36 See in Reactome R-HSA-2187264 ( R-HSA-3000471 ) R-HSA-2187264 Reaction Name: Platelet glycoprotein IV (CD36) binds ligands See in Reactome R-HSA-2201316 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2201316 Reaction Name: Activated TLR2/4 interacts with MAL (TIRAP) See in Reactome R-HSA-2201322 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2201322 Reaction Name: TIRAP is phosphorylated by BTK See in Reactome R-HSA-2247512 ( R-HSA-3000471 ) R-HSA-2247512 Reaction Name: Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed See in Reactome R-HSA-2262775 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2262775 Reaction Name: Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-2262777 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2262777 Reaction Name: TRAF6 binds to p-IRAK2 See in Reactome R-HSA-2559414 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2559414 Reaction Name: Activated TLR2/4:TIRAP interacts with BTK See in Reactome R-HSA-2559464 ( R-HSA-168188 ) R-HSA-2559464 Reaction Name: TLR6/2 ligand associates with CD14 and CD36 within lipid rafts See in Reactome R-HSA-434381 ( R-HSA-434313 ) R-HSA-434381 Reaction Name: CD36 (FAT) translocates palmitate from the extracellular region to the cytosol See in Reactome R-HSA-481044 ( R-HSA-114608 ) R-HSA-481044 Reaction Name: Surface deployment of platelet alpha granule membrane components See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-6797267 ( R-HSA-6785807 ) R-HSA-6797267 Reaction Name: Expression of CD36 See in Reactome R-HSA-6799350 ( R-HSA-6798695 ) R-HSA-6799350 Reaction Name: Exocytosis of specific granule membrane proteins See in Reactome R-HSA-8863895 ( R-HSA-1236974 ) R-HSA-8863895 Reaction Name: IKKB phosphorylates SNAP23 See in Reactome R-HSA-8869667 ( R-HSA-5686938 ) R-HSA-8869667 Reaction Name: oxLDL:CD36 binds TLR4:TLR6 See in Reactome R-HSA-937022 ( R-HSA-166058; R-HSA-168188 ) R-HSA-937022 Reaction Name: IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP See in Reactome R-HSA-937059 ( R-HSA-166058; R-HSA-168188 ) R-HSA-937059 Reaction Name: Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex See in Reactome R-HSA-937079 ( R-HSA-166058; R-HSA-168188 ) R-HSA-937079 Reaction Name: MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 See in Reactome
MONDO:0012585	CD36	P16671	-	R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-434313 R-HSA-434313 Reactome Name: Intracellular metabolism of fatty acids regulates insulin secretion See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome R-HSA-1236973 R-HSA-1236973 Reactome Name: Cross-presentation of particulate exogenous antigens (phagosomes) See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-1236974 R-HSA-1236974 Reactome Name: ER-Phagosome pathway See in Reactome R-HSA-3000471 R-HSA-3000471 Reactome Name: Scavenging by Class B Receptors See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5686938 R-HSA-5686938 Reactome Name: Regulation of TLR by endogenous ligand See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-400451 R-HSA-400451 Reactome Name: Free fatty acids regulate insulin secretion See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-2173782 R-HSA-2173782 Reactome Name: Binding and Uptake of Ligands by Scavenger Receptors See in Reactome	Immune System Metabolism Developmental Biology Vesicle-mediated transport Hemostasis	R-HSA-1236956 ( R-HSA-1236973 ) R-HSA-1236956 Reaction Name: Engulfment of particulate antigen into phagocytic vesicle See in Reactome R-HSA-1236958 ( R-HSA-1236973 ) R-HSA-1236958 Reaction Name: Interaction of particulate antigens with dendritic cell receptors See in Reactome R-HSA-166072 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166072 Reaction Name: MyD88 forms a complex with TIRAP:activated TLR2/4 See in Reactome R-HSA-166082 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166082 Reaction Name: IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex See in Reactome R-HSA-166091 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166091 Reaction Name: IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex See in Reactome R-HSA-166119 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166119 Reaction Name: First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal See in Reactome R-HSA-166284 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166284 Reaction Name: Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP See in Reactome R-HSA-166286 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166286 Reaction Name: Multiple IRAK1 autophosphorylation steps See in Reactome R-HSA-166362 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166362 Reaction Name: Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-166363 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166363 Reaction Name: TRAF6 binds to hp- IRAK1 See in Reactome R-HSA-168950 ( R-HSA-168188 ) R-HSA-168950 Reaction Name: TLR6:TLR2 is recruited to ligand:CD14:CD36 See in Reactome R-HSA-2187264 ( R-HSA-3000471 ) R-HSA-2187264 Reaction Name: Platelet glycoprotein IV (CD36) binds ligands See in Reactome R-HSA-2201316 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2201316 Reaction Name: Activated TLR2/4 interacts with MAL (TIRAP) See in Reactome R-HSA-2201322 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2201322 Reaction Name: TIRAP is phosphorylated by BTK See in Reactome R-HSA-2247512 ( R-HSA-3000471 ) R-HSA-2247512 Reaction Name: Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed See in Reactome R-HSA-2262775 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2262775 Reaction Name: Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-2262777 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2262777 Reaction Name: TRAF6 binds to p-IRAK2 See in Reactome R-HSA-2559414 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2559414 Reaction Name: Activated TLR2/4:TIRAP interacts with BTK See in Reactome R-HSA-2559464 ( R-HSA-168188 ) R-HSA-2559464 Reaction Name: TLR6/2 ligand associates with CD14 and CD36 within lipid rafts See in Reactome R-HSA-434381 ( R-HSA-434313 ) R-HSA-434381 Reaction Name: CD36 (FAT) translocates palmitate from the extracellular region to the cytosol See in Reactome R-HSA-481044 ( R-HSA-114608 ) R-HSA-481044 Reaction Name: Surface deployment of platelet alpha granule membrane components See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-6797267 ( R-HSA-6785807 ) R-HSA-6797267 Reaction Name: Expression of CD36 See in Reactome R-HSA-6799350 ( R-HSA-6798695 ) R-HSA-6799350 Reaction Name: Exocytosis of specific granule membrane proteins See in Reactome R-HSA-8863895 ( R-HSA-1236974 ) R-HSA-8863895 Reaction Name: IKKB phosphorylates SNAP23 See in Reactome R-HSA-8869667 ( R-HSA-5686938 ) R-HSA-8869667 Reaction Name: oxLDL:CD36 binds TLR4:TLR6 See in Reactome R-HSA-937022 ( R-HSA-166058; R-HSA-168188 ) R-HSA-937022 Reaction Name: IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP See in Reactome R-HSA-937059 ( R-HSA-166058; R-HSA-168188 ) R-HSA-937059 Reaction Name: Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex See in Reactome R-HSA-937079 ( R-HSA-166058; R-HSA-168188 ) R-HSA-937079 Reaction Name: MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 See in Reactome