DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-429947)

Number of enzymes:	2
Number of disease:	4
Number of reactomes:	10
Number of reactions:	25

Search results (Reactome ID: R-HSA-429947)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009998	EIF4A3	P38919	3.6.4.13	R-HSA-72163 R-HSA-72163 Reactome Name: mRNA Splicing - Major Pathway See in Reactome R-HSA-975957 R-HSA-975957 Reactome Name: Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) See in Reactome R-HSA-429947 R-HSA-429947 Reactome Name: Deadenylation of mRNA See in Reactome R-HSA-159236 R-HSA-159236 Reactome Name: Transport of Mature mRNA derived from an Intron-Containing Transcript See in Reactome R-HSA-1169408 R-HSA-1169408 Reactome Name: ISG15 antiviral mechanism See in Reactome R-HSA-72187 R-HSA-72187 Reactome Name: mRNA 3'-end processing See in Reactome R-HSA-9010553 R-HSA-9010553 Reactome Name: Regulation of expression of SLITs and ROBOs See in Reactome R-HSA-73856 R-HSA-73856 Reactome Name: RNA Polymerase II Transcription Termination See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-72172 R-HSA-72172 Reactome Name: mRNA Splicing See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-72202 R-HSA-72202 Reactome Name: Transport of Mature Transcript to Cytoplasm See in Reactome R-HSA-72203 R-HSA-72203 Reactome Name: Processing of Capped Intron-Containing Pre-mRNA See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-1169410 R-HSA-1169410 Reactome Name: Antiviral mechanism by IFN-stimulated genes See in Reactome R-HSA-927802 R-HSA-927802 Reactome Name: Nonsense-Mediated Decay (NMD) See in Reactome R-HSA-429914 R-HSA-429914 Reactome Name: Deadenylation-dependent mRNA decay See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of RNA Immune System Developmental Biology	R-HSA-156661 ( R-HSA-72163 ) R-HSA-156661 Reaction Name: Formation of Exon Junction Complex See in Reactome R-HSA-159101 ( R-HSA-159236 ) R-HSA-159101 Reaction Name: NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) See in Reactome R-HSA-1678842 ( R-HSA-1169408 ) R-HSA-1678842 Reaction Name: Competitive inhibition of translation initiation by ISGylated 4EHP See in Reactome R-HSA-429955 ( R-HSA-429947 ) R-HSA-429955 Reaction Name: CCR4-NOT complex deadenylates mRNA See in Reactome R-HSA-429992 ( R-HSA-429947 ) R-HSA-429992 Reaction Name: PARN deadenylates mRNA See in Reactome R-HSA-430021 ( R-HSA-429947 ) R-HSA-430021 Reaction Name: PAN2-PAN3 complex partially deadenylates mRNA See in Reactome R-HSA-72130 ( R-HSA-72163 ) R-HSA-72130 Reaction Name: Formation of an intermediate Spliceosomal C complex See in Reactome R-HSA-72139 ( R-HSA-72163 ) R-HSA-72139 Reaction Name: Formation of the active Spliceosomal C complex See in Reactome R-HSA-72143 ( R-HSA-72163 ) R-HSA-72143 Reaction Name: Lariat Formation and 5'-Splice Site Cleavage See in Reactome R-HSA-72160 ( R-HSA-72163 ) R-HSA-72160 Reaction Name: Cleavage at the 3'-Splice Site and Exon Ligation See in Reactome R-HSA-72180 ( R-HSA-72187; R-HSA-73856 ) R-HSA-72180 Reaction Name: Cleavage of mRNA at the 3'-end See in Reactome R-HSA-72185 ( R-HSA-72187 ) R-HSA-72185 Reaction Name: mRNA polyadenylation See in Reactome R-HSA-75096 ( R-HSA-159236 ) R-HSA-75096 Reaction Name: Docking of the TAP:EJC Complex with the NPC See in Reactome R-HSA-75097 ( R-HSA-159236 ) R-HSA-75097 Reaction Name: Transport of the export-competent mRNP complex through the NPC See in Reactome R-HSA-75098 ( R-HSA-159236 ) R-HSA-75098 Reaction Name: mRNP complex dissociates from cytosolic face of NPC See in Reactome R-HSA-8849157 ( R-HSA-72187 ) R-HSA-8849157 Reaction Name: TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally See in Reactome R-HSA-8941312 ( R-HSA-429947 ) R-HSA-8941312 Reaction Name: ZCCHC6, ZCCHC11 are mRNA uridyltransferases See in Reactome R-HSA-9014610 ( R-HSA-9010553 ) R-HSA-9014610 Reaction Name: Translation of ROBO3.2 mRNA initiates NMD See in Reactome R-HSA-9014652 ( R-HSA-9010553 ) R-HSA-9014652 Reaction Name: Translation of ROBO3.2 mRNA is negatively regulated by NMD See in Reactome R-HSA-927813 ( R-HSA-975957 ) R-HSA-927813 Reaction Name: p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A See in Reactome R-HSA-927832 ( R-HSA-975957 ) R-HSA-927832 Reaction Name: UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex See in Reactome R-HSA-927836 ( R-HSA-975957 ) R-HSA-927836 Reaction Name: SMG6 hydrolyzes mRNA with premature termination codon See in Reactome R-HSA-927889 ( R-HSA-975957 ) R-HSA-927889 Reaction Name: SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) See in Reactome
MONDO:0014600	PARN	O95453	3.1.13.4	R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-380994 R-HSA-380994 Reactome Name: ATF4 activates genes in response to endoplasmic reticulum stress See in Reactome R-HSA-429947 R-HSA-429947 Reactome Name: Deadenylation of mRNA See in Reactome	R-HSA-381042 R-HSA-381042 Reactome Name: PERK regulates gene expression See in Reactome R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-429914 R-HSA-429914 Reactome Name: Deadenylation-dependent mRNA decay See in Reactome	Cellular responses to stimuli Metabolism of RNA	R-HSA-429992 ( R-HSA-429947 ) R-HSA-429992 Reaction Name: PARN deadenylates mRNA See in Reactome R-HSA-450422 ( R-HSA-450604 ) R-HSA-450422 Reaction Name: KSRP recruits RNA degradation activities See in Reactome R-HSA-517731 ( R-HSA-380994 ) R-HSA-517731 Reaction Name: Expression of IL-8 See in Reactome
MONDO:0014612	PARN	O95453	3.1.13.4	R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-380994 R-HSA-380994 Reactome Name: ATF4 activates genes in response to endoplasmic reticulum stress See in Reactome R-HSA-429947 R-HSA-429947 Reactome Name: Deadenylation of mRNA See in Reactome	R-HSA-381042 R-HSA-381042 Reactome Name: PERK regulates gene expression See in Reactome R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-429914 R-HSA-429914 Reactome Name: Deadenylation-dependent mRNA decay See in Reactome	Cellular responses to stimuli Metabolism of RNA	R-HSA-429992 ( R-HSA-429947 ) R-HSA-429992 Reaction Name: PARN deadenylates mRNA See in Reactome R-HSA-450422 ( R-HSA-450604 ) R-HSA-450422 Reaction Name: KSRP recruits RNA degradation activities See in Reactome R-HSA-517731 ( R-HSA-380994 ) R-HSA-517731 Reaction Name: Expression of IL-8 See in Reactome
MONDO:0018045	PARN	O95453	3.1.13.4	R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-380994 R-HSA-380994 Reactome Name: ATF4 activates genes in response to endoplasmic reticulum stress See in Reactome R-HSA-429947 R-HSA-429947 Reactome Name: Deadenylation of mRNA See in Reactome	R-HSA-381042 R-HSA-381042 Reactome Name: PERK regulates gene expression See in Reactome R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-429914 R-HSA-429914 Reactome Name: Deadenylation-dependent mRNA decay See in Reactome	Cellular responses to stimuli Metabolism of RNA	R-HSA-429992 ( R-HSA-429947 ) R-HSA-429992 Reaction Name: PARN deadenylates mRNA See in Reactome R-HSA-450422 ( R-HSA-450604 ) R-HSA-450422 Reaction Name: KSRP recruits RNA degradation activities See in Reactome R-HSA-517731 ( R-HSA-380994 ) R-HSA-517731 Reaction Name: Expression of IL-8 See in Reactome