MONDO:0001071 |
MONDO:0001071
Disease Name: intellectual disability
Orphanet id: Orphanet:319658
All associated enzymes in DAR:
CYP2U1
DHX16
CBS
POLG
UFSP2
P4HTM
PDIA3
DHX30
TET3
ALG3
NAGLU
CHD3
SMPD1
DHX34
GCH1
CARNMT1
CYP27A1
ABCD1
CHD2
DDX54
INO80
PTPN4
DHX37
CHD3 |
Q12873 |
3.6.4.12
|
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-427389
R-HSA-427389
Reactome Name: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
See in Reactome
R-HSA-4551638
R-HSA-4551638
Reactome Name: SUMOylation of chromatin organization proteins
See in Reactome
R-HSA-73762
R-HSA-73762
Reactome Name: RNA Polymerase I Transcription Initiation
See in Reactome
R-HSA-3214815
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-6807070
R-HSA-5633007
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-3108232
R-HSA-3108232
Reactome Name: SUMO E3 ligases SUMOylate target proteins
See in Reactome
R-HSA-392499
R-HSA-5250913
R-HSA-5250913
Reactome Name: Positive epigenetic regulation of rRNA expression
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-73864
R-HSA-4839726
R-HSA-2990846
R-HSA-212165
R-HSA-212165
Reactome Name: Epigenetic regulation of gene expression
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-3247509
R-HSA-73854
R-HSA-73854
Reactome Name: RNA Polymerase I Promoter Clearance
See in Reactome
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Metabolism of proteins
Chromatin organization
Signal Transduction
|
R-HSA-3769447
(
R-HSA-3214815
)
R-HSA-3769447
Reaction Name: HDAC1:2-containing complex deacetylate histones
See in Reactome
R-HSA-427336
(
R-HSA-427389
)
R-HSA-427336
Reaction Name: TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9.
See in Reactome
R-HSA-427404
(
R-HSA-427389
)
R-HSA-427404
Reaction Name: Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene
See in Reactome
R-HSA-6805650
(
R-HSA-6804758
)
R-HSA-6805650
Reaction Name: MTA2-NuRD complex deacetylates TP53
See in Reactome
R-HSA-73739
(
R-HSA-73762
)
R-HSA-73739
Reaction Name: Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter
See in Reactome
R-HSA-8943780
(
R-HSA-8943724
)
R-HSA-8943780
Reaction Name: SALL4 recruits NuRD to PTEN gene
See in Reactome
R-HSA-8944104
(
R-HSA-8943724
)
R-HSA-8944104
Reaction Name: PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN
See in Reactome
R-HSA-8956365
(
R-HSA-4551638
)
R-HSA-8956365
Reaction Name: ZBED1 (DREF) SUMOylates CHD3 with SUMO1
See in Reactome
R-HSA-9679787
(
R-HSA-3214815
)
R-HSA-9679787
Reaction Name: HDAC1:2-containing complex binds HDAC2 Inhibitors
See in Reactome
|
MONDO:0008955 |
ERCC6 |
Q03468 |
3.6.4.-
|
R-HSA-6781827
R-HSA-6781827
Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER)
See in Reactome
R-HSA-427389
R-HSA-427389
Reactome Name: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
See in Reactome
R-HSA-6781823
R-HSA-6781823
Reactome Name: Formation of TC-NER Pre-Incision Complex
See in Reactome
R-HSA-6782135
R-HSA-5250924
R-HSA-5250924
Reactome Name: B-WICH complex positively regulates rRNA expression
See in Reactome
R-HSA-6782210
R-HSA-6782210
Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER
See in Reactome
R-HSA-73762
R-HSA-73762
Reactome Name: RNA Polymerase I Transcription Initiation
See in Reactome
|
R-HSA-74160
R-HSA-5696398
R-HSA-5250913
R-HSA-5250913
Reactome Name: Positive epigenetic regulation of rRNA expression
See in Reactome
R-HSA-212165
R-HSA-212165
Reactome Name: Epigenetic regulation of gene expression
See in Reactome
R-HSA-73894
R-HSA-73864
R-HSA-73854
R-HSA-73854
Reactome Name: RNA Polymerase I Promoter Clearance
See in Reactome
|
Gene expression (Transcription)
DNA Repair
|
R-HSA-427336
(
R-HSA-427389
)
R-HSA-427336
Reaction Name: TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9.
See in Reactome
R-HSA-427404
(
R-HSA-427389
)
R-HSA-427404
Reaction Name: Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene
See in Reactome
R-HSA-5250930
(
R-HSA-5250924
)
R-HSA-5250930
Reaction Name: B-WICH recruits histone acetyltransferases
See in Reactome
R-HSA-5250938
(
R-HSA-5250924
)
R-HSA-5250938
Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9
See in Reactome
R-HSA-5250947
(
R-HSA-5250924
)
R-HSA-5250947
Reaction Name: B-WICH complex binds rDNA promoter
See in Reactome
R-HSA-6781833
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781833
Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II
See in Reactome
R-HSA-6781840
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781840
Reaction Name: ERCC6 binds stalled RNA Pol II
See in Reactome
R-HSA-6781867
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781867
Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II
See in Reactome
R-HSA-6782004
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6782004
Reaction Name: Assembly of the pre-incision complex in TC-NER
See in Reactome
R-HSA-6782069
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6782069
Reaction Name: UVSSA:USP7 deubiquitinates ERCC6
See in Reactome
R-HSA-6782131
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782131
Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER
See in Reactome
R-HSA-6782138
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782138
Reaction Name: ERCC5 and RPA bind TC-NER site
See in Reactome
R-HSA-6782141
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782141
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
See in Reactome
R-HSA-6782204
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782204
Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
See in Reactome
R-HSA-6782208
(
R-HSA-6781827;
R-HSA-6782210
)
R-HSA-6782208
Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER
See in Reactome
R-HSA-6782211
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782211
Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site
See in Reactome
R-HSA-6782224
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782224
Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER
See in Reactome
R-HSA-6782227
(
R-HSA-6781827;
R-HSA-6782210
)
R-HSA-6782227
Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER
See in Reactome
R-HSA-6782234
(
R-HSA-6781827
)
R-HSA-6782234
Reaction Name: Recovery of RNA synthesis after TC-NER
See in Reactome
R-HSA-73739
(
R-HSA-73762
)
R-HSA-73739
Reaction Name: Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter
See in Reactome
R-HSA-9684118
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-9684118
Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER
See in Reactome
|
MONDO:0008998 |
ERCC6 |
Q03468 |
3.6.4.-
|
R-HSA-6781827
R-HSA-6781827
Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER)
See in Reactome
R-HSA-427389
R-HSA-427389
Reactome Name: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
See in Reactome
R-HSA-6781823
R-HSA-6781823
Reactome Name: Formation of TC-NER Pre-Incision Complex
See in Reactome
R-HSA-6782135
R-HSA-5250924
R-HSA-5250924
Reactome Name: B-WICH complex positively regulates rRNA expression
See in Reactome
R-HSA-6782210
R-HSA-6782210
Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER
See in Reactome
R-HSA-73762
R-HSA-73762
Reactome Name: RNA Polymerase I Transcription Initiation
See in Reactome
|
R-HSA-74160
R-HSA-5696398
R-HSA-5250913
R-HSA-5250913
Reactome Name: Positive epigenetic regulation of rRNA expression
See in Reactome
R-HSA-212165
R-HSA-212165
Reactome Name: Epigenetic regulation of gene expression
See in Reactome
R-HSA-73894
R-HSA-73864
R-HSA-73854
R-HSA-73854
Reactome Name: RNA Polymerase I Promoter Clearance
See in Reactome
|
Gene expression (Transcription)
DNA Repair
|
R-HSA-427336
(
R-HSA-427389
)
R-HSA-427336
Reaction Name: TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9.
See in Reactome
R-HSA-427404
(
R-HSA-427389
)
R-HSA-427404
Reaction Name: Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene
See in Reactome
R-HSA-5250930
(
R-HSA-5250924
)
R-HSA-5250930
Reaction Name: B-WICH recruits histone acetyltransferases
See in Reactome
R-HSA-5250938
(
R-HSA-5250924
)
R-HSA-5250938
Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9
See in Reactome
R-HSA-5250947
(
R-HSA-5250924
)
R-HSA-5250947
Reaction Name: B-WICH complex binds rDNA promoter
See in Reactome
R-HSA-6781833
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781833
Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II
See in Reactome
R-HSA-6781840
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781840
Reaction Name: ERCC6 binds stalled RNA Pol II
See in Reactome
R-HSA-6781867
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781867
Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II
See in Reactome
R-HSA-6782004
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6782004
Reaction Name: Assembly of the pre-incision complex in TC-NER
See in Reactome
R-HSA-6782069
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6782069
Reaction Name: UVSSA:USP7 deubiquitinates ERCC6
See in Reactome
R-HSA-6782131
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782131
Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER
See in Reactome
R-HSA-6782138
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782138
Reaction Name: ERCC5 and RPA bind TC-NER site
See in Reactome
R-HSA-6782141
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782141
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
See in Reactome
R-HSA-6782204
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782204
Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
See in Reactome
R-HSA-6782208
(
R-HSA-6781827;
R-HSA-6782210
)
R-HSA-6782208
Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER
See in Reactome
R-HSA-6782211
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782211
Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site
See in Reactome
R-HSA-6782224
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782224
Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER
See in Reactome
R-HSA-6782227
(
R-HSA-6781827;
R-HSA-6782210
)
R-HSA-6782227
Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER
See in Reactome
R-HSA-6782234
(
R-HSA-6781827
)
R-HSA-6782234
Reaction Name: Recovery of RNA synthesis after TC-NER
See in Reactome
R-HSA-73739
(
R-HSA-73762
)
R-HSA-73739
Reaction Name: Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter
See in Reactome
R-HSA-9684118
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-9684118
Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER
See in Reactome
|
MONDO:0010217 |
ERCC6 |
Q03468 |
3.6.4.-
|
R-HSA-6781827
R-HSA-6781827
Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER)
See in Reactome
R-HSA-427389
R-HSA-427389
Reactome Name: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
See in Reactome
R-HSA-6781823
R-HSA-6781823
Reactome Name: Formation of TC-NER Pre-Incision Complex
See in Reactome
R-HSA-6782135
R-HSA-5250924
R-HSA-5250924
Reactome Name: B-WICH complex positively regulates rRNA expression
See in Reactome
R-HSA-6782210
R-HSA-6782210
Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER
See in Reactome
R-HSA-73762
R-HSA-73762
Reactome Name: RNA Polymerase I Transcription Initiation
See in Reactome
|
R-HSA-74160
R-HSA-5696398
R-HSA-5250913
R-HSA-5250913
Reactome Name: Positive epigenetic regulation of rRNA expression
See in Reactome
R-HSA-212165
R-HSA-212165
Reactome Name: Epigenetic regulation of gene expression
See in Reactome
R-HSA-73894
R-HSA-73864
R-HSA-73854
R-HSA-73854
Reactome Name: RNA Polymerase I Promoter Clearance
See in Reactome
|
Gene expression (Transcription)
DNA Repair
|
R-HSA-427336
(
R-HSA-427389
)
R-HSA-427336
Reaction Name: TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9.
See in Reactome
R-HSA-427404
(
R-HSA-427389
)
R-HSA-427404
Reaction Name: Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene
See in Reactome
R-HSA-5250930
(
R-HSA-5250924
)
R-HSA-5250930
Reaction Name: B-WICH recruits histone acetyltransferases
See in Reactome
R-HSA-5250938
(
R-HSA-5250924
)
R-HSA-5250938
Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9
See in Reactome
R-HSA-5250947
(
R-HSA-5250924
)
R-HSA-5250947
Reaction Name: B-WICH complex binds rDNA promoter
See in Reactome
R-HSA-6781833
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781833
Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II
See in Reactome
R-HSA-6781840
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781840
Reaction Name: ERCC6 binds stalled RNA Pol II
See in Reactome
R-HSA-6781867
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781867
Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II
See in Reactome
R-HSA-6782004
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6782004
Reaction Name: Assembly of the pre-incision complex in TC-NER
See in Reactome
R-HSA-6782069
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6782069
Reaction Name: UVSSA:USP7 deubiquitinates ERCC6
See in Reactome
R-HSA-6782131
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782131
Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER
See in Reactome
R-HSA-6782138
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782138
Reaction Name: ERCC5 and RPA bind TC-NER site
See in Reactome
R-HSA-6782141
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782141
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
See in Reactome
R-HSA-6782204
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782204
Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
See in Reactome
R-HSA-6782208
(
R-HSA-6781827;
R-HSA-6782210
)
R-HSA-6782208
Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER
See in Reactome
R-HSA-6782211
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782211
Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site
See in Reactome
R-HSA-6782224
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782224
Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER
See in Reactome
R-HSA-6782227
(
R-HSA-6781827;
R-HSA-6782210
)
R-HSA-6782227
Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER
See in Reactome
R-HSA-6782234
(
R-HSA-6781827
)
R-HSA-6782234
Reaction Name: Recovery of RNA synthesis after TC-NER
See in Reactome
R-HSA-73739
(
R-HSA-73762
)
R-HSA-73739
Reaction Name: Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter
See in Reactome
R-HSA-9684118
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-9684118
Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER
See in Reactome
|
MONDO:0010909 |
ERCC6 |
Q03468 |
3.6.4.-
|
R-HSA-6781827
R-HSA-6781827
Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER)
See in Reactome
R-HSA-427389
R-HSA-427389
Reactome Name: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
See in Reactome
R-HSA-6781823
R-HSA-6781823
Reactome Name: Formation of TC-NER Pre-Incision Complex
See in Reactome
R-HSA-6782135
R-HSA-5250924
R-HSA-5250924
Reactome Name: B-WICH complex positively regulates rRNA expression
See in Reactome
R-HSA-6782210
R-HSA-6782210
Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER
See in Reactome
R-HSA-73762
R-HSA-73762
Reactome Name: RNA Polymerase I Transcription Initiation
See in Reactome
|
R-HSA-74160
R-HSA-5696398
R-HSA-5250913
R-HSA-5250913
Reactome Name: Positive epigenetic regulation of rRNA expression
See in Reactome
R-HSA-212165
R-HSA-212165
Reactome Name: Epigenetic regulation of gene expression
See in Reactome
R-HSA-73894
R-HSA-73864
R-HSA-73854
R-HSA-73854
Reactome Name: RNA Polymerase I Promoter Clearance
See in Reactome
|
Gene expression (Transcription)
DNA Repair
|
R-HSA-427336
(
R-HSA-427389
)
R-HSA-427336
Reaction Name: TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9.
See in Reactome
R-HSA-427404
(
R-HSA-427389
)
R-HSA-427404
Reaction Name: Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene
See in Reactome
R-HSA-5250930
(
R-HSA-5250924
)
R-HSA-5250930
Reaction Name: B-WICH recruits histone acetyltransferases
See in Reactome
R-HSA-5250938
(
R-HSA-5250924
)
R-HSA-5250938
Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9
See in Reactome
R-HSA-5250947
(
R-HSA-5250924
)
R-HSA-5250947
Reaction Name: B-WICH complex binds rDNA promoter
See in Reactome
R-HSA-6781833
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781833
Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II
See in Reactome
R-HSA-6781840
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781840
Reaction Name: ERCC6 binds stalled RNA Pol II
See in Reactome
R-HSA-6781867
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781867
Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II
See in Reactome
R-HSA-6782004
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6782004
Reaction Name: Assembly of the pre-incision complex in TC-NER
See in Reactome
R-HSA-6782069
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6782069
Reaction Name: UVSSA:USP7 deubiquitinates ERCC6
See in Reactome
R-HSA-6782131
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782131
Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER
See in Reactome
R-HSA-6782138
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782138
Reaction Name: ERCC5 and RPA bind TC-NER site
See in Reactome
R-HSA-6782141
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782141
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
See in Reactome
R-HSA-6782204
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782204
Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
See in Reactome
R-HSA-6782208
(
R-HSA-6781827;
R-HSA-6782210
)
R-HSA-6782208
Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER
See in Reactome
R-HSA-6782211
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782211
Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site
See in Reactome
R-HSA-6782224
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782224
Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER
See in Reactome
R-HSA-6782227
(
R-HSA-6781827;
R-HSA-6782210
)
R-HSA-6782227
Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER
See in Reactome
R-HSA-6782234
(
R-HSA-6781827
)
R-HSA-6782234
Reaction Name: Recovery of RNA synthesis after TC-NER
See in Reactome
R-HSA-73739
(
R-HSA-73762
)
R-HSA-73739
Reaction Name: Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter
See in Reactome
R-HSA-9684118
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-9684118
Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER
See in Reactome
|
MONDO:0013409 |
ERCC6 |
Q03468 |
3.6.4.-
|
R-HSA-6781827
R-HSA-6781827
Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER)
See in Reactome
R-HSA-427389
R-HSA-427389
Reactome Name: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
See in Reactome
R-HSA-6781823
R-HSA-6781823
Reactome Name: Formation of TC-NER Pre-Incision Complex
See in Reactome
R-HSA-6782135
R-HSA-5250924
R-HSA-5250924
Reactome Name: B-WICH complex positively regulates rRNA expression
See in Reactome
R-HSA-6782210
R-HSA-6782210
Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER
See in Reactome
R-HSA-73762
R-HSA-73762
Reactome Name: RNA Polymerase I Transcription Initiation
See in Reactome
|
R-HSA-74160
R-HSA-5696398
R-HSA-5250913
R-HSA-5250913
Reactome Name: Positive epigenetic regulation of rRNA expression
See in Reactome
R-HSA-212165
R-HSA-212165
Reactome Name: Epigenetic regulation of gene expression
See in Reactome
R-HSA-73894
R-HSA-73864
R-HSA-73854
R-HSA-73854
Reactome Name: RNA Polymerase I Promoter Clearance
See in Reactome
|
Gene expression (Transcription)
DNA Repair
|
R-HSA-427336
(
R-HSA-427389
)
R-HSA-427336
Reaction Name: TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9.
See in Reactome
R-HSA-427404
(
R-HSA-427389
)
R-HSA-427404
Reaction Name: Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene
See in Reactome
R-HSA-5250930
(
R-HSA-5250924
)
R-HSA-5250930
Reaction Name: B-WICH recruits histone acetyltransferases
See in Reactome
R-HSA-5250938
(
R-HSA-5250924
)
R-HSA-5250938
Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9
See in Reactome
R-HSA-5250947
(
R-HSA-5250924
)
R-HSA-5250947
Reaction Name: B-WICH complex binds rDNA promoter
See in Reactome
R-HSA-6781833
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781833
Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II
See in Reactome
R-HSA-6781840
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781840
Reaction Name: ERCC6 binds stalled RNA Pol II
See in Reactome
R-HSA-6781867
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781867
Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II
See in Reactome
R-HSA-6782004
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6782004
Reaction Name: Assembly of the pre-incision complex in TC-NER
See in Reactome
R-HSA-6782069
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6782069
Reaction Name: UVSSA:USP7 deubiquitinates ERCC6
See in Reactome
R-HSA-6782131
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782131
Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER
See in Reactome
R-HSA-6782138
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782138
Reaction Name: ERCC5 and RPA bind TC-NER site
See in Reactome
R-HSA-6782141
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782141
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
See in Reactome
R-HSA-6782204
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782204
Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
See in Reactome
R-HSA-6782208
(
R-HSA-6781827;
R-HSA-6782210
)
R-HSA-6782208
Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER
See in Reactome
R-HSA-6782211
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782211
Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site
See in Reactome
R-HSA-6782224
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782224
Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER
See in Reactome
R-HSA-6782227
(
R-HSA-6781827;
R-HSA-6782210
)
R-HSA-6782227
Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER
See in Reactome
R-HSA-6782234
(
R-HSA-6781827
)
R-HSA-6782234
Reaction Name: Recovery of RNA synthesis after TC-NER
See in Reactome
R-HSA-73739
(
R-HSA-73762
)
R-HSA-73739
Reaction Name: Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter
See in Reactome
R-HSA-9684118
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-9684118
Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER
See in Reactome
|
MONDO:0014843 |
ERCC6 |
Q03468 |
3.6.4.-
|
R-HSA-6781827
R-HSA-6781827
Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER)
See in Reactome
R-HSA-427389
R-HSA-427389
Reactome Name: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
See in Reactome
R-HSA-6781823
R-HSA-6781823
Reactome Name: Formation of TC-NER Pre-Incision Complex
See in Reactome
R-HSA-6782135
R-HSA-5250924
R-HSA-5250924
Reactome Name: B-WICH complex positively regulates rRNA expression
See in Reactome
R-HSA-6782210
R-HSA-6782210
Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER
See in Reactome
R-HSA-73762
R-HSA-73762
Reactome Name: RNA Polymerase I Transcription Initiation
See in Reactome
|
R-HSA-74160
R-HSA-5696398
R-HSA-5250913
R-HSA-5250913
Reactome Name: Positive epigenetic regulation of rRNA expression
See in Reactome
R-HSA-212165
R-HSA-212165
Reactome Name: Epigenetic regulation of gene expression
See in Reactome
R-HSA-73894
R-HSA-73864
R-HSA-73854
R-HSA-73854
Reactome Name: RNA Polymerase I Promoter Clearance
See in Reactome
|
Gene expression (Transcription)
DNA Repair
|
R-HSA-427336
(
R-HSA-427389
)
R-HSA-427336
Reaction Name: TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9.
See in Reactome
R-HSA-427404
(
R-HSA-427389
)
R-HSA-427404
Reaction Name: Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene
See in Reactome
R-HSA-5250930
(
R-HSA-5250924
)
R-HSA-5250930
Reaction Name: B-WICH recruits histone acetyltransferases
See in Reactome
R-HSA-5250938
(
R-HSA-5250924
)
R-HSA-5250938
Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9
See in Reactome
R-HSA-5250947
(
R-HSA-5250924
)
R-HSA-5250947
Reaction Name: B-WICH complex binds rDNA promoter
See in Reactome
R-HSA-6781833
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781833
Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II
See in Reactome
R-HSA-6781840
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781840
Reaction Name: ERCC6 binds stalled RNA Pol II
See in Reactome
R-HSA-6781867
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781867
Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II
See in Reactome
R-HSA-6782004
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6782004
Reaction Name: Assembly of the pre-incision complex in TC-NER
See in Reactome
R-HSA-6782069
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6782069
Reaction Name: UVSSA:USP7 deubiquitinates ERCC6
See in Reactome
R-HSA-6782131
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782131
Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER
See in Reactome
R-HSA-6782138
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782138
Reaction Name: ERCC5 and RPA bind TC-NER site
See in Reactome
R-HSA-6782141
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782141
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
See in Reactome
R-HSA-6782204
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782204
Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
See in Reactome
R-HSA-6782208
(
R-HSA-6781827;
R-HSA-6782210
)
R-HSA-6782208
Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER
See in Reactome
R-HSA-6782211
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782211
Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site
See in Reactome
R-HSA-6782224
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782224
Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER
See in Reactome
R-HSA-6782227
(
R-HSA-6781827;
R-HSA-6782210
)
R-HSA-6782227
Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER
See in Reactome
R-HSA-6782234
(
R-HSA-6781827
)
R-HSA-6782234
Reaction Name: Recovery of RNA synthesis after TC-NER
See in Reactome
R-HSA-73739
(
R-HSA-73762
)
R-HSA-73739
Reaction Name: Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter
See in Reactome
R-HSA-9684118
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-9684118
Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER
See in Reactome
|
MONDO:0014946 |
CHD4 |
Q14839 |
3.6.4.12
|
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-427389
R-HSA-427389
Reactome Name: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
See in Reactome
R-HSA-9031628
R-HSA-73762
R-HSA-73762
Reactome Name: RNA Polymerase I Transcription Initiation
See in Reactome
R-HSA-3214815
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-6807070
R-HSA-5633007
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-1257604
R-HSA-5250913
R-HSA-5250913
Reactome Name: Positive epigenetic regulation of rRNA expression
See in Reactome
R-HSA-4839726
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-73864
R-HSA-198725
R-HSA-198725
Reactome Name: Nuclear Events (kinase and transcription factor activation)
See in Reactome
R-HSA-162582
R-HSA-212165
R-HSA-212165
Reactome Name: Epigenetic regulation of gene expression
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-3247509
R-HSA-73854
R-HSA-73854
Reactome Name: RNA Polymerase I Promoter Clearance
See in Reactome
R-HSA-187037
R-HSA-73857
|
Gene expression (Transcription)
Chromatin organization
Signal Transduction
|
R-HSA-3769447
(
R-HSA-3214815
)
R-HSA-3769447
Reaction Name: HDAC1:2-containing complex deacetylate histones
See in Reactome
R-HSA-427336
(
R-HSA-427389
)
R-HSA-427336
Reaction Name: TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9.
See in Reactome
R-HSA-427404
(
R-HSA-427389
)
R-HSA-427404
Reaction Name: Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene
See in Reactome
R-HSA-6805650
(
R-HSA-6804758
)
R-HSA-6805650
Reaction Name: MTA2-NuRD complex deacetylates TP53
See in Reactome
R-HSA-73739
(
R-HSA-73762
)
R-HSA-73739
Reaction Name: Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter
See in Reactome
R-HSA-8943780
(
R-HSA-8943724
)
R-HSA-8943780
Reaction Name: SALL4 recruits NuRD to PTEN gene
See in Reactome
R-HSA-8944104
(
R-HSA-8943724
)
R-HSA-8944104
Reaction Name: PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN
See in Reactome
R-HSA-9612534
(
R-HSA-9031628
)
R-HSA-9612534
Reaction Name: Expression of ID2 and ID4 is repressed by EGR2:NAB
See in Reactome
R-HSA-9613213
(
R-HSA-9031628
)
R-HSA-9613213
Reaction Name: NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression
See in Reactome
R-HSA-9613219
(
R-HSA-9031628
)
R-HSA-9613476
(
R-HSA-9031628
)
R-HSA-9613476
Reaction Name: EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions
See in Reactome
R-HSA-9679787
(
R-HSA-3214815
)
R-HSA-9679787
Reaction Name: HDAC1:2-containing complex binds HDAC2 Inhibitors
See in Reactome
|
MONDO:0019569 |
ERCC6 |
Q03468 |
3.6.4.-
|
R-HSA-6781827
R-HSA-6781827
Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER)
See in Reactome
R-HSA-427389
R-HSA-427389
Reactome Name: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
See in Reactome
R-HSA-6781823
R-HSA-6781823
Reactome Name: Formation of TC-NER Pre-Incision Complex
See in Reactome
R-HSA-6782135
R-HSA-5250924
R-HSA-5250924
Reactome Name: B-WICH complex positively regulates rRNA expression
See in Reactome
R-HSA-6782210
R-HSA-6782210
Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER
See in Reactome
R-HSA-73762
R-HSA-73762
Reactome Name: RNA Polymerase I Transcription Initiation
See in Reactome
|
R-HSA-74160
R-HSA-5696398
R-HSA-5250913
R-HSA-5250913
Reactome Name: Positive epigenetic regulation of rRNA expression
See in Reactome
R-HSA-212165
R-HSA-212165
Reactome Name: Epigenetic regulation of gene expression
See in Reactome
R-HSA-73894
R-HSA-73864
R-HSA-73854
R-HSA-73854
Reactome Name: RNA Polymerase I Promoter Clearance
See in Reactome
|
Gene expression (Transcription)
DNA Repair
|
R-HSA-427336
(
R-HSA-427389
)
R-HSA-427336
Reaction Name: TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9.
See in Reactome
R-HSA-427404
(
R-HSA-427389
)
R-HSA-427404
Reaction Name: Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene
See in Reactome
R-HSA-5250930
(
R-HSA-5250924
)
R-HSA-5250930
Reaction Name: B-WICH recruits histone acetyltransferases
See in Reactome
R-HSA-5250938
(
R-HSA-5250924
)
R-HSA-5250938
Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9
See in Reactome
R-HSA-5250947
(
R-HSA-5250924
)
R-HSA-5250947
Reaction Name: B-WICH complex binds rDNA promoter
See in Reactome
R-HSA-6781833
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781833
Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II
See in Reactome
R-HSA-6781840
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781840
Reaction Name: ERCC6 binds stalled RNA Pol II
See in Reactome
R-HSA-6781867
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781867
Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II
See in Reactome
R-HSA-6782004
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6782004
Reaction Name: Assembly of the pre-incision complex in TC-NER
See in Reactome
R-HSA-6782069
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6782069
Reaction Name: UVSSA:USP7 deubiquitinates ERCC6
See in Reactome
R-HSA-6782131
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782131
Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER
See in Reactome
R-HSA-6782138
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782138
Reaction Name: ERCC5 and RPA bind TC-NER site
See in Reactome
R-HSA-6782141
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782141
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
See in Reactome
R-HSA-6782204
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782204
Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
See in Reactome
R-HSA-6782208
(
R-HSA-6781827;
R-HSA-6782210
)
R-HSA-6782208
Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER
See in Reactome
R-HSA-6782211
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782211
Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site
See in Reactome
R-HSA-6782224
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782224
Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER
See in Reactome
R-HSA-6782227
(
R-HSA-6781827;
R-HSA-6782210
)
R-HSA-6782227
Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER
See in Reactome
R-HSA-6782234
(
R-HSA-6781827
)
R-HSA-6782234
Reaction Name: Recovery of RNA synthesis after TC-NER
See in Reactome
R-HSA-73739
(
R-HSA-73762
)
R-HSA-73739
Reaction Name: Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter
See in Reactome
R-HSA-9684118
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-9684118
Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER
See in Reactome
|
MONDO:0019570 |
ERCC6 |
Q03468 |
3.6.4.-
|
R-HSA-6781827
R-HSA-6781827
Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER)
See in Reactome
R-HSA-427389
R-HSA-427389
Reactome Name: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
See in Reactome
R-HSA-6781823
R-HSA-6781823
Reactome Name: Formation of TC-NER Pre-Incision Complex
See in Reactome
R-HSA-6782135
R-HSA-5250924
R-HSA-5250924
Reactome Name: B-WICH complex positively regulates rRNA expression
See in Reactome
R-HSA-6782210
R-HSA-6782210
Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER
See in Reactome
R-HSA-73762
R-HSA-73762
Reactome Name: RNA Polymerase I Transcription Initiation
See in Reactome
|
R-HSA-74160
R-HSA-5696398
R-HSA-5250913
R-HSA-5250913
Reactome Name: Positive epigenetic regulation of rRNA expression
See in Reactome
R-HSA-212165
R-HSA-212165
Reactome Name: Epigenetic regulation of gene expression
See in Reactome
R-HSA-73894
R-HSA-73864
R-HSA-73854
R-HSA-73854
Reactome Name: RNA Polymerase I Promoter Clearance
See in Reactome
|
Gene expression (Transcription)
DNA Repair
|
R-HSA-427336
(
R-HSA-427389
)
R-HSA-427336
Reaction Name: TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9.
See in Reactome
R-HSA-427404
(
R-HSA-427389
)
R-HSA-427404
Reaction Name: Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene
See in Reactome
R-HSA-5250930
(
R-HSA-5250924
)
R-HSA-5250930
Reaction Name: B-WICH recruits histone acetyltransferases
See in Reactome
R-HSA-5250938
(
R-HSA-5250924
)
R-HSA-5250938
Reaction Name: B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9
See in Reactome
R-HSA-5250947
(
R-HSA-5250924
)
R-HSA-5250947
Reaction Name: B-WICH complex binds rDNA promoter
See in Reactome
R-HSA-6781833
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781833
Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II
See in Reactome
R-HSA-6781840
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781840
Reaction Name: ERCC6 binds stalled RNA Pol II
See in Reactome
R-HSA-6781867
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6781867
Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II
See in Reactome
R-HSA-6782004
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6782004
Reaction Name: Assembly of the pre-incision complex in TC-NER
See in Reactome
R-HSA-6782069
(
R-HSA-6781823;
R-HSA-6781827
)
R-HSA-6782069
Reaction Name: UVSSA:USP7 deubiquitinates ERCC6
See in Reactome
R-HSA-6782131
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782131
Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER
See in Reactome
R-HSA-6782138
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782138
Reaction Name: ERCC5 and RPA bind TC-NER site
See in Reactome
R-HSA-6782141
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782141
Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
See in Reactome
R-HSA-6782204
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782204
Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
See in Reactome
R-HSA-6782208
(
R-HSA-6781827;
R-HSA-6782210
)
R-HSA-6782208
Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER
See in Reactome
R-HSA-6782211
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782211
Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site
See in Reactome
R-HSA-6782224
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-6782224
Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER
See in Reactome
R-HSA-6782227
(
R-HSA-6781827;
R-HSA-6782210
)
R-HSA-6782227
Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER
See in Reactome
R-HSA-6782234
(
R-HSA-6781827
)
R-HSA-6782234
Reaction Name: Recovery of RNA synthesis after TC-NER
See in Reactome
R-HSA-73739
(
R-HSA-73762
)
R-HSA-73739
Reaction Name: Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter
See in Reactome
R-HSA-9684118
(
R-HSA-6781827;
R-HSA-6782135
)
R-HSA-9684118
Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER
See in Reactome
|
MONDO:0032600 |
CHD3 |
Q12873 |
3.6.4.12
|
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-427389
R-HSA-427389
Reactome Name: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
See in Reactome
R-HSA-4551638
R-HSA-4551638
Reactome Name: SUMOylation of chromatin organization proteins
See in Reactome
R-HSA-73762
R-HSA-73762
Reactome Name: RNA Polymerase I Transcription Initiation
See in Reactome
R-HSA-3214815
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-6807070
R-HSA-5633007
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-3108232
R-HSA-3108232
Reactome Name: SUMO E3 ligases SUMOylate target proteins
See in Reactome
R-HSA-392499
R-HSA-5250913
R-HSA-5250913
Reactome Name: Positive epigenetic regulation of rRNA expression
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-73864
R-HSA-4839726
R-HSA-2990846
R-HSA-212165
R-HSA-212165
Reactome Name: Epigenetic regulation of gene expression
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-3247509
R-HSA-73854
R-HSA-73854
Reactome Name: RNA Polymerase I Promoter Clearance
See in Reactome
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Metabolism of proteins
Chromatin organization
Signal Transduction
|
R-HSA-3769447
(
R-HSA-3214815
)
R-HSA-3769447
Reaction Name: HDAC1:2-containing complex deacetylate histones
See in Reactome
R-HSA-427336
(
R-HSA-427389
)
R-HSA-427336
Reaction Name: TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9.
See in Reactome
R-HSA-427404
(
R-HSA-427389
)
R-HSA-427404
Reaction Name: Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene
See in Reactome
R-HSA-6805650
(
R-HSA-6804758
)
R-HSA-6805650
Reaction Name: MTA2-NuRD complex deacetylates TP53
See in Reactome
R-HSA-73739
(
R-HSA-73762
)
R-HSA-73739
Reaction Name: Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter
See in Reactome
R-HSA-8943780
(
R-HSA-8943724
)
R-HSA-8943780
Reaction Name: SALL4 recruits NuRD to PTEN gene
See in Reactome
R-HSA-8944104
(
R-HSA-8943724
)
R-HSA-8944104
Reaction Name: PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN
See in Reactome
R-HSA-8956365
(
R-HSA-4551638
)
R-HSA-8956365
Reaction Name: ZBED1 (DREF) SUMOylates CHD3 with SUMO1
See in Reactome
R-HSA-9679787
(
R-HSA-3214815
)
R-HSA-9679787
Reaction Name: HDAC1:2-containing complex binds HDAC2 Inhibitors
See in Reactome
|