DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-418597)

Number of enzymes:	6
Number of disease:	10
Number of reactomes:	30
Number of reactions:	49

Search results (Reactome ID: R-HSA-418597)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0001595	ADCY5	O95622	4.6.1.1	R-HSA-170670 R-HSA-170670 Reactome Name: Adenylate cyclase inhibitory pathway See in Reactome R-HSA-163615 R-HSA-163615 Reactome Name: PKA activation See in Reactome R-HSA-170660 R-HSA-170660 Reactome Name: Adenylate cyclase activating pathway See in Reactome R-HSA-400042 R-HSA-400042 Reactome Name: Adrenaline,noradrenaline inhibits insulin secretion See in Reactome R-HSA-164378 R-HSA-164378 Reactome Name: PKA activation in glucagon signalling See in Reactome R-HSA-418597 R-HSA-418597 Reactome Name: G alpha (z) signalling events See in Reactome R-HSA-381676 R-HSA-381676 Reactome Name: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-432040 R-HSA-432040 Reactome Name: Vasopressin regulates renal water homeostasis via Aquaporins See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome R-HSA-163359 R-HSA-163359 Reactome Name: Glucagon signaling in metabolic regulation See in Reactome	R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-111931 R-HSA-111931 Reactome Name: PKA-mediated phosphorylation of CREB See in Reactome R-HSA-977443 R-HSA-977443 Reactome Name: GABA receptor activation See in Reactome R-HSA-977444 R-HSA-977444 Reactome Name: GABA B receptor activation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-445717 R-HSA-445717 Reactome Name: Aquaporin-mediated transport See in Reactome R-HSA-991365 R-HSA-991365 Reactome Name: Activation of GABAB receptors See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Transport of small molecules Metabolism Neuronal System Signal Transduction	R-HSA-111930 ( R-HSA-163615; R-HSA-418594 ) R-HSA-111930 Reaction Name: Adenylate cyclase produces cAMP See in Reactome R-HSA-163617 ( R-HSA-163359; R-HSA-418555; R-HSA-432040 ) R-HSA-163617 Reaction Name: G alpha (s) activates adenylate cyclase See in Reactome R-HSA-164377 ( R-HSA-163359; R-HSA-164378; R-HSA-432040 ) R-HSA-164377 Reaction Name: Activated Adenylate cyclase catalyses cAMP synthesis See in Reactome R-HSA-170666 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170666 Reaction Name: Adenylate cyclase increases the GTPase activity of G alpha-olf See in Reactome R-HSA-170671 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170671 Reaction Name: G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex See in Reactome R-HSA-170672 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170672 Reaction Name: Galpha-olf:GTP binds to adenylate cyclase and activates it See in Reactome R-HSA-170674 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170674 Reaction Name: Dissociation of the Gi alpha:G olf complex See in Reactome R-HSA-170676 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170676 Reaction Name: Adenylate cyclase converts ATP into cyclic AMP See in Reactome R-HSA-170677 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170677 Reaction Name: The G alpha-olf:GDP:Adenylate cyclase complex dissociates See in Reactome R-HSA-170685 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170685 Reaction Name: Adenylaye cyclase increases the GTPase activity of G alpha-olf See in Reactome R-HSA-170686 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170686 Reaction Name: Adenylate cyclase increases the GTPase activity of Gi alpha See in Reactome R-HSA-381607 ( R-HSA-381676 ) R-HSA-381607 Reaction Name: Activated Adenylyl cyclase synthesizes cyclic AMP See in Reactome R-HSA-381704 ( R-HSA-163359; R-HSA-381676 ) R-HSA-381704 Reaction Name: G(s):GTP activates Adenylyl cyclase See in Reactome R-HSA-392064 ( R-HSA-418597 ) R-HSA-392064 Reaction Name: G alpha (z) inhibits adenylate cyclase See in Reactome R-HSA-392129 ( R-HSA-418555; R-HSA-418594; R-HSA-418597 ) R-HSA-392129 Reaction Name: Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate See in Reactome R-HSA-392206 ( R-HSA-170670; R-HSA-418594 ) R-HSA-392206 Reaction Name: G alpha (i) inhibits adenylate cyclase See in Reactome R-HSA-400097 ( R-HSA-400042 ) R-HSA-400097 Reaction Name: G-beta:G-gamma inhibits Adenylate cyclase See in Reactome R-HSA-5610727 ( R-HSA-5610787 ) R-HSA-5610727 Reaction Name: GPR161 promotes cAMP production in a G alpha(s)-dependent manner See in Reactome
MONDO:0011540	PRKCG	P05129	2.7.11.13	R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-418597 R-HSA-418597 Reactome Name: G alpha (z) signalling events See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-416993 R-HSA-416993 Reactome Name: Trafficking of GluR2-containing AMPA receptors See in Reactome R-HSA-5099900 R-HSA-5099900 Reactome Name: WNT5A-dependent internalization of FZD4 See in Reactome R-HSA-114516 R-HSA-114516 Reactome Name: Disinhibition of SNARE formation See in Reactome	R-HSA-399721 R-HSA-399721 Reactome Name: Glutamate binding, activation of AMPA receptors and synaptic plasticity See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-399719 R-HSA-399719 Reactome Name: Trafficking of AMPA receptors See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome	Hemostasis Neuronal System Signal Transduction	R-HSA-111966 ( R-HSA-111933; R-HSA-1489509; R-HSA-418594 ) R-HSA-111966 Reaction Name: GRK2 binds CALM1:4Ca2+ See in Reactome R-HSA-111970 ( R-HSA-111933; R-HSA-1489509; R-HSA-418594 ) R-HSA-111970 Reaction Name: PKC phosphorylates GRK2 See in Reactome R-HSA-114553 ( R-HSA-76005 ) R-HSA-114553 Reaction Name: Activation of conventional Protein Kinase C See in Reactome R-HSA-114683 ( R-HSA-114516; R-HSA-76005 ) R-HSA-114683 Reaction Name: Phosphorylation of Platelet Sec-1 See in Reactome R-HSA-114684 ( R-HSA-114516; R-HSA-76005 ) R-HSA-114684 Reaction Name: Phosphorylation of Syntaxin-4 See in Reactome R-HSA-416639 ( R-HSA-416993 ) R-HSA-416639 Reaction Name: Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites See in Reactome R-HSA-421007 ( R-HSA-416993 ) R-HSA-421007 Reaction Name: Endocytosis of Ca impermeable AMPA receptors See in Reactome R-HSA-5138432 ( R-HSA-5099900 ) R-HSA-5138432 Reaction Name: DVL2 is phosphorylated by PKC See in Reactome R-HSA-751040 ( R-HSA-418597 ) R-HSA-751040 Reaction Name: PKC phosphorylates G alpha (z) See in Reactome R-HSA-8982703 ( R-HSA-418597 ) R-HSA-8982703 Reaction Name: PKC binds active G alpha (z) See in Reactome R-HSA-8982709 ( R-HSA-418597 ) R-HSA-8982709 Reaction Name: G-alpha(z):PKC dissociates to give phosphorylated G alpha (z) See in Reactome
MONDO:0011707	ADCY5	O95622	4.6.1.1	R-HSA-170670 R-HSA-170670 Reactome Name: Adenylate cyclase inhibitory pathway See in Reactome R-HSA-163615 R-HSA-163615 Reactome Name: PKA activation See in Reactome R-HSA-170660 R-HSA-170660 Reactome Name: Adenylate cyclase activating pathway See in Reactome R-HSA-400042 R-HSA-400042 Reactome Name: Adrenaline,noradrenaline inhibits insulin secretion See in Reactome R-HSA-164378 R-HSA-164378 Reactome Name: PKA activation in glucagon signalling See in Reactome R-HSA-418597 R-HSA-418597 Reactome Name: G alpha (z) signalling events See in Reactome R-HSA-381676 R-HSA-381676 Reactome Name: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-432040 R-HSA-432040 Reactome Name: Vasopressin regulates renal water homeostasis via Aquaporins See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome R-HSA-163359 R-HSA-163359 Reactome Name: Glucagon signaling in metabolic regulation See in Reactome	R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-111931 R-HSA-111931 Reactome Name: PKA-mediated phosphorylation of CREB See in Reactome R-HSA-977443 R-HSA-977443 Reactome Name: GABA receptor activation See in Reactome R-HSA-977444 R-HSA-977444 Reactome Name: GABA B receptor activation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-445717 R-HSA-445717 Reactome Name: Aquaporin-mediated transport See in Reactome R-HSA-991365 R-HSA-991365 Reactome Name: Activation of GABAB receptors See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Transport of small molecules Metabolism Neuronal System Signal Transduction	R-HSA-111930 ( R-HSA-163615; R-HSA-418594 ) R-HSA-111930 Reaction Name: Adenylate cyclase produces cAMP See in Reactome R-HSA-163617 ( R-HSA-163359; R-HSA-418555; R-HSA-432040 ) R-HSA-163617 Reaction Name: G alpha (s) activates adenylate cyclase See in Reactome R-HSA-164377 ( R-HSA-163359; R-HSA-164378; R-HSA-432040 ) R-HSA-164377 Reaction Name: Activated Adenylate cyclase catalyses cAMP synthesis See in Reactome R-HSA-170666 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170666 Reaction Name: Adenylate cyclase increases the GTPase activity of G alpha-olf See in Reactome R-HSA-170671 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170671 Reaction Name: G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex See in Reactome R-HSA-170672 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170672 Reaction Name: Galpha-olf:GTP binds to adenylate cyclase and activates it See in Reactome R-HSA-170674 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170674 Reaction Name: Dissociation of the Gi alpha:G olf complex See in Reactome R-HSA-170676 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170676 Reaction Name: Adenylate cyclase converts ATP into cyclic AMP See in Reactome R-HSA-170677 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170677 Reaction Name: The G alpha-olf:GDP:Adenylate cyclase complex dissociates See in Reactome R-HSA-170685 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170685 Reaction Name: Adenylaye cyclase increases the GTPase activity of G alpha-olf See in Reactome R-HSA-170686 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170686 Reaction Name: Adenylate cyclase increases the GTPase activity of Gi alpha See in Reactome R-HSA-381607 ( R-HSA-381676 ) R-HSA-381607 Reaction Name: Activated Adenylyl cyclase synthesizes cyclic AMP See in Reactome R-HSA-381704 ( R-HSA-163359; R-HSA-381676 ) R-HSA-381704 Reaction Name: G(s):GTP activates Adenylyl cyclase See in Reactome R-HSA-392064 ( R-HSA-418597 ) R-HSA-392064 Reaction Name: G alpha (z) inhibits adenylate cyclase See in Reactome R-HSA-392129 ( R-HSA-418555; R-HSA-418594; R-HSA-418597 ) R-HSA-392129 Reaction Name: Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate See in Reactome R-HSA-392206 ( R-HSA-170670; R-HSA-418594 ) R-HSA-392206 Reaction Name: G alpha (i) inhibits adenylate cyclase See in Reactome R-HSA-400097 ( R-HSA-400042 ) R-HSA-400097 Reaction Name: G-beta:G-gamma inhibits Adenylate cyclase See in Reactome R-HSA-5610727 ( R-HSA-5610787 ) R-HSA-5610727 Reaction Name: GPR161 promotes cAMP production in a G alpha(s)-dependent manner See in Reactome
MONDO:0012421	ADCY1	Q08828	4.6.1.1	R-HSA-170670 R-HSA-170670 Reactome Name: Adenylate cyclase inhibitory pathway See in Reactome R-HSA-442720 R-HSA-442720 Reactome Name: CREB1 phosphorylation through the activation of Adenylate Cyclase See in Reactome R-HSA-163615 R-HSA-163615 Reactome Name: PKA activation See in Reactome R-HSA-170660 R-HSA-170660 Reactome Name: Adenylate cyclase activating pathway See in Reactome R-HSA-164378 R-HSA-164378 Reactome Name: PKA activation in glucagon signalling See in Reactome R-HSA-418597 R-HSA-418597 Reactome Name: G alpha (z) signalling events See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-432040 R-HSA-432040 Reactome Name: Vasopressin regulates renal water homeostasis via Aquaporins See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome R-HSA-163359 R-HSA-163359 Reactome Name: Glucagon signaling in metabolic regulation See in Reactome	R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-111931 R-HSA-111931 Reactome Name: PKA-mediated phosphorylation of CREB See in Reactome R-HSA-977443 R-HSA-977443 Reactome Name: GABA receptor activation See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-977444 R-HSA-977444 Reactome Name: GABA B receptor activation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-445717 R-HSA-445717 Reactome Name: Aquaporin-mediated transport See in Reactome R-HSA-991365 R-HSA-991365 Reactome Name: Activation of GABAB receptors See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Transport of small molecules Metabolism Neuronal System Signal Transduction	R-HSA-111930 ( R-HSA-111933; R-HSA-1489509; R-HSA-163615; R-HSA-418594 ) R-HSA-111930 Reaction Name: Adenylate cyclase produces cAMP See in Reactome R-HSA-163617 ( R-HSA-163359; R-HSA-418555; R-HSA-432040 ) R-HSA-163617 Reaction Name: G alpha (s) activates adenylate cyclase See in Reactome R-HSA-164377 ( R-HSA-163359; R-HSA-164378; R-HSA-432040 ) R-HSA-164377 Reaction Name: Activated Adenylate cyclase catalyses cAMP synthesis See in Reactome R-HSA-170666 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170666 Reaction Name: Adenylate cyclase increases the GTPase activity of G alpha-olf See in Reactome R-HSA-170671 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170671 Reaction Name: G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex See in Reactome R-HSA-170672 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170672 Reaction Name: Galpha-olf:GTP binds to adenylate cyclase and activates it See in Reactome R-HSA-170674 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170674 Reaction Name: Dissociation of the Gi alpha:G olf complex See in Reactome R-HSA-170676 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170676 Reaction Name: Adenylate cyclase converts ATP into cyclic AMP See in Reactome R-HSA-170677 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170677 Reaction Name: The G alpha-olf:GDP:Adenylate cyclase complex dissociates See in Reactome R-HSA-170685 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170685 Reaction Name: Adenylaye cyclase increases the GTPase activity of G alpha-olf See in Reactome R-HSA-170686 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170686 Reaction Name: Adenylate cyclase increases the GTPase activity of Gi alpha See in Reactome R-HSA-392064 ( R-HSA-418597 ) R-HSA-392064 Reaction Name: G alpha (z) inhibits adenylate cyclase See in Reactome R-HSA-392129 ( R-HSA-418555; R-HSA-418594; R-HSA-418597 ) R-HSA-392129 Reaction Name: Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate See in Reactome R-HSA-392206 ( R-HSA-170670; R-HSA-418594 ) R-HSA-392206 Reaction Name: G alpha (i) inhibits adenylate cyclase See in Reactome R-HSA-442715 ( R-HSA-442720 ) R-HSA-442715 Reaction Name: Calmodulin-activated adenylate cyclases ADCY1 and ADCY8 generate cAMP See in Reactome R-HSA-5610727 ( R-HSA-5610787 ) R-HSA-5610727 Reaction Name: GPR161 promotes cAMP production in a G alpha(s)-dependent manner See in Reactome R-HSA-9617535 ( R-HSA-442720 ) R-HSA-9617535 Reaction Name: Activated calmodulin binds ADCY1,ADCY8 See in Reactome
MONDO:0013743	PRKCD	Q05655	2.7.11.13 2.7.10.2	R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-111465 R-HSA-111465 Reactome Name: Apoptotic cleavage of cellular proteins See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-418597 R-HSA-418597 Reactome Name: G alpha (z) signalling events See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-450520 R-HSA-450520 Reactome Name: HuR (ELAVL1) binds and stabilizes mRNA See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-114508 R-HSA-114508 Reactome Name: Effects of PIP2 hydrolysis See in Reactome	R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-75153 R-HSA-75153 Reactome Name: Apoptotic execution phase See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Metabolism of RNA Programmed Cell Death Signal Transduction Hemostasis	R-HSA-111966 ( R-HSA-111933; R-HSA-1489509; R-HSA-418594 ) R-HSA-111966 Reaction Name: GRK2 binds CALM1:4Ca2+ See in Reactome R-HSA-111970 ( R-HSA-111933; R-HSA-1489509; R-HSA-418594 ) R-HSA-111970 Reaction Name: PKC phosphorylates GRK2 See in Reactome R-HSA-198314 ( R-HSA-1489509; R-HSA-2029485 ) R-HSA-198314 Reaction Name: DAG stimulates protein kinase C-delta See in Reactome R-HSA-212552 ( R-HSA-111465 ) R-HSA-212552 Reaction Name: Caspase 3-mediated cleavage of PKC delta See in Reactome R-HSA-425861 ( R-HSA-114508 ) R-HSA-425861 Reaction Name: Activation of Protein Kinase C novel isoforms See in Reactome R-HSA-450533 ( R-HSA-450520 ) R-HSA-450533 Reaction Name: PKCdelta phosphorylates HuR See in Reactome R-HSA-5218805 ( R-HSA-5218921 ) R-HSA-5218805 Reaction Name: PKC autophosphorylates See in Reactome R-HSA-5218813 ( R-HSA-5218921 ) R-HSA-5218813 Reaction Name: DAG and Ca+2 bind to PKC and tether it to membrane See in Reactome R-HSA-5218821 ( R-HSA-5218921 ) R-HSA-5218821 Reaction Name: PDK1 phosphorylates PKC See in Reactome R-HSA-5218823 ( R-HSA-5218921 ) R-HSA-5218823 Reaction Name: PKC phosphorylates sphingosine kinase 1 See in Reactome R-HSA-5607734 ( R-HSA-5607764 ) R-HSA-5607734 Reaction Name: PKC-delta translocates to plasma membrane See in Reactome R-HSA-5607740 ( R-HSA-5607764 ) R-HSA-5607740 Reaction Name: PKC-delta phosphorylates CARD9 See in Reactome R-HSA-5607746 ( R-HSA-5607764 ) R-HSA-5607746 Reaction Name: PKC-delta is activated See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-751040 ( R-HSA-418597 ) R-HSA-751040 Reaction Name: PKC phosphorylates G alpha (z) See in Reactome R-HSA-8932284 () R-HSA-8932284 Reaction Name: PKC phosphorylates NFE2L2 See in Reactome R-HSA-8934446 ( R-HSA-1250196 ) R-HSA-8934446 Reaction Name: Activated PKC phosphorylates SHC1 See in Reactome R-HSA-8982703 ( R-HSA-418597 ) R-HSA-8982703 Reaction Name: PKC binds active G alpha (z) See in Reactome R-HSA-8982709 ( R-HSA-418597 ) R-HSA-8982709 Reaction Name: G-alpha(z):PKC dissociates to give phosphorylated G alpha (z) See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-9626817 ( R-HSA-5668599 ) R-HSA-9626817 Reaction Name: PKC phosphorylates NCF1 See in Reactome
MONDO:0014253	PRKCD	Q05655	2.7.11.13 2.7.10.2	R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-111465 R-HSA-111465 Reactome Name: Apoptotic cleavage of cellular proteins See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-418597 R-HSA-418597 Reactome Name: G alpha (z) signalling events See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-450520 R-HSA-450520 Reactome Name: HuR (ELAVL1) binds and stabilizes mRNA See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-114508 R-HSA-114508 Reactome Name: Effects of PIP2 hydrolysis See in Reactome	R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-75153 R-HSA-75153 Reactome Name: Apoptotic execution phase See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Metabolism of RNA Programmed Cell Death Signal Transduction Hemostasis	R-HSA-111966 ( R-HSA-111933; R-HSA-1489509; R-HSA-418594 ) R-HSA-111966 Reaction Name: GRK2 binds CALM1:4Ca2+ See in Reactome R-HSA-111970 ( R-HSA-111933; R-HSA-1489509; R-HSA-418594 ) R-HSA-111970 Reaction Name: PKC phosphorylates GRK2 See in Reactome R-HSA-198314 ( R-HSA-1489509; R-HSA-2029485 ) R-HSA-198314 Reaction Name: DAG stimulates protein kinase C-delta See in Reactome R-HSA-212552 ( R-HSA-111465 ) R-HSA-212552 Reaction Name: Caspase 3-mediated cleavage of PKC delta See in Reactome R-HSA-425861 ( R-HSA-114508 ) R-HSA-425861 Reaction Name: Activation of Protein Kinase C novel isoforms See in Reactome R-HSA-450533 ( R-HSA-450520 ) R-HSA-450533 Reaction Name: PKCdelta phosphorylates HuR See in Reactome R-HSA-5218805 ( R-HSA-5218921 ) R-HSA-5218805 Reaction Name: PKC autophosphorylates See in Reactome R-HSA-5218813 ( R-HSA-5218921 ) R-HSA-5218813 Reaction Name: DAG and Ca+2 bind to PKC and tether it to membrane See in Reactome R-HSA-5218821 ( R-HSA-5218921 ) R-HSA-5218821 Reaction Name: PDK1 phosphorylates PKC See in Reactome R-HSA-5218823 ( R-HSA-5218921 ) R-HSA-5218823 Reaction Name: PKC phosphorylates sphingosine kinase 1 See in Reactome R-HSA-5607734 ( R-HSA-5607764 ) R-HSA-5607734 Reaction Name: PKC-delta translocates to plasma membrane See in Reactome R-HSA-5607740 ( R-HSA-5607764 ) R-HSA-5607740 Reaction Name: PKC-delta phosphorylates CARD9 See in Reactome R-HSA-5607746 ( R-HSA-5607764 ) R-HSA-5607746 Reaction Name: PKC-delta is activated See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-751040 ( R-HSA-418597 ) R-HSA-751040 Reaction Name: PKC phosphorylates G alpha (z) See in Reactome R-HSA-8932284 () R-HSA-8932284 Reaction Name: PKC phosphorylates NFE2L2 See in Reactome R-HSA-8934446 ( R-HSA-1250196 ) R-HSA-8934446 Reaction Name: Activated PKC phosphorylates SHC1 See in Reactome R-HSA-8982703 ( R-HSA-418597 ) R-HSA-8982703 Reaction Name: PKC binds active G alpha (z) See in Reactome R-HSA-8982709 ( R-HSA-418597 ) R-HSA-8982709 Reaction Name: G-alpha(z):PKC dissociates to give phosphorylated G alpha (z) See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-9626817 ( R-HSA-5668599 ) R-HSA-9626817 Reaction Name: PKC phosphorylates NCF1 See in Reactome
MONDO:0014570	ADCY6	O43306	4.6.1.1	R-HSA-170670 R-HSA-170670 Reactome Name: Adenylate cyclase inhibitory pathway See in Reactome R-HSA-163615 R-HSA-163615 Reactome Name: PKA activation See in Reactome R-HSA-170660 R-HSA-170660 Reactome Name: Adenylate cyclase activating pathway See in Reactome R-HSA-400042 R-HSA-400042 Reactome Name: Adrenaline,noradrenaline inhibits insulin secretion See in Reactome R-HSA-164378 R-HSA-164378 Reactome Name: PKA activation in glucagon signalling See in Reactome R-HSA-418597 R-HSA-418597 Reactome Name: G alpha (z) signalling events See in Reactome R-HSA-381676 R-HSA-381676 Reactome Name: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-432040 R-HSA-432040 Reactome Name: Vasopressin regulates renal water homeostasis via Aquaporins See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome R-HSA-163359 R-HSA-163359 Reactome Name: Glucagon signaling in metabolic regulation See in Reactome	R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-111931 R-HSA-111931 Reactome Name: PKA-mediated phosphorylation of CREB See in Reactome R-HSA-977443 R-HSA-977443 Reactome Name: GABA receptor activation See in Reactome R-HSA-977444 R-HSA-977444 Reactome Name: GABA B receptor activation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-445717 R-HSA-445717 Reactome Name: Aquaporin-mediated transport See in Reactome R-HSA-991365 R-HSA-991365 Reactome Name: Activation of GABAB receptors See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Transport of small molecules Metabolism Neuronal System Signal Transduction	R-HSA-111930 ( R-HSA-163615; R-HSA-418594 ) R-HSA-111930 Reaction Name: Adenylate cyclase produces cAMP See in Reactome R-HSA-163617 ( R-HSA-163359; R-HSA-418555; R-HSA-432040 ) R-HSA-163617 Reaction Name: G alpha (s) activates adenylate cyclase See in Reactome R-HSA-164377 ( R-HSA-163359; R-HSA-164378; R-HSA-432040 ) R-HSA-164377 Reaction Name: Activated Adenylate cyclase catalyses cAMP synthesis See in Reactome R-HSA-170666 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170666 Reaction Name: Adenylate cyclase increases the GTPase activity of G alpha-olf See in Reactome R-HSA-170671 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170671 Reaction Name: G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex See in Reactome R-HSA-170672 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170672 Reaction Name: Galpha-olf:GTP binds to adenylate cyclase and activates it See in Reactome R-HSA-170674 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170674 Reaction Name: Dissociation of the Gi alpha:G olf complex See in Reactome R-HSA-170676 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170676 Reaction Name: Adenylate cyclase converts ATP into cyclic AMP See in Reactome R-HSA-170677 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170677 Reaction Name: The G alpha-olf:GDP:Adenylate cyclase complex dissociates See in Reactome R-HSA-170685 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170685 Reaction Name: Adenylaye cyclase increases the GTPase activity of G alpha-olf See in Reactome R-HSA-170686 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170686 Reaction Name: Adenylate cyclase increases the GTPase activity of Gi alpha See in Reactome R-HSA-381607 ( R-HSA-381676 ) R-HSA-381607 Reaction Name: Activated Adenylyl cyclase synthesizes cyclic AMP See in Reactome R-HSA-381704 ( R-HSA-163359; R-HSA-381676 ) R-HSA-381704 Reaction Name: G(s):GTP activates Adenylyl cyclase See in Reactome R-HSA-392064 ( R-HSA-418597 ) R-HSA-392064 Reaction Name: G alpha (z) inhibits adenylate cyclase See in Reactome R-HSA-392129 ( R-HSA-418555; R-HSA-418594; R-HSA-418597 ) R-HSA-392129 Reaction Name: Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate See in Reactome R-HSA-392206 ( R-HSA-170670; R-HSA-418594 ) R-HSA-392206 Reaction Name: G alpha (i) inhibits adenylate cyclase See in Reactome R-HSA-400097 ( R-HSA-400042 ) R-HSA-400097 Reaction Name: G-beta:G-gamma inhibits Adenylate cyclase See in Reactome R-HSA-5610727 ( R-HSA-5610787 ) R-HSA-5610727 Reaction Name: GPR161 promotes cAMP production in a G alpha(s)-dependent manner See in Reactome
MONDO:0015517	PRKCD	Q05655	2.7.11.13 2.7.10.2	R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-111465 R-HSA-111465 Reactome Name: Apoptotic cleavage of cellular proteins See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-418597 R-HSA-418597 Reactome Name: G alpha (z) signalling events See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-450520 R-HSA-450520 Reactome Name: HuR (ELAVL1) binds and stabilizes mRNA See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-114508 R-HSA-114508 Reactome Name: Effects of PIP2 hydrolysis See in Reactome	R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-75153 R-HSA-75153 Reactome Name: Apoptotic execution phase See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Metabolism of RNA Programmed Cell Death Signal Transduction Hemostasis	R-HSA-111966 ( R-HSA-111933; R-HSA-1489509; R-HSA-418594 ) R-HSA-111966 Reaction Name: GRK2 binds CALM1:4Ca2+ See in Reactome R-HSA-111970 ( R-HSA-111933; R-HSA-1489509; R-HSA-418594 ) R-HSA-111970 Reaction Name: PKC phosphorylates GRK2 See in Reactome R-HSA-198314 ( R-HSA-1489509; R-HSA-2029485 ) R-HSA-198314 Reaction Name: DAG stimulates protein kinase C-delta See in Reactome R-HSA-212552 ( R-HSA-111465 ) R-HSA-212552 Reaction Name: Caspase 3-mediated cleavage of PKC delta See in Reactome R-HSA-425861 ( R-HSA-114508 ) R-HSA-425861 Reaction Name: Activation of Protein Kinase C novel isoforms See in Reactome R-HSA-450533 ( R-HSA-450520 ) R-HSA-450533 Reaction Name: PKCdelta phosphorylates HuR See in Reactome R-HSA-5218805 ( R-HSA-5218921 ) R-HSA-5218805 Reaction Name: PKC autophosphorylates See in Reactome R-HSA-5218813 ( R-HSA-5218921 ) R-HSA-5218813 Reaction Name: DAG and Ca+2 bind to PKC and tether it to membrane See in Reactome R-HSA-5218821 ( R-HSA-5218921 ) R-HSA-5218821 Reaction Name: PDK1 phosphorylates PKC See in Reactome R-HSA-5218823 ( R-HSA-5218921 ) R-HSA-5218823 Reaction Name: PKC phosphorylates sphingosine kinase 1 See in Reactome R-HSA-5607734 ( R-HSA-5607764 ) R-HSA-5607734 Reaction Name: PKC-delta translocates to plasma membrane See in Reactome R-HSA-5607740 ( R-HSA-5607764 ) R-HSA-5607740 Reaction Name: PKC-delta phosphorylates CARD9 See in Reactome R-HSA-5607746 ( R-HSA-5607764 ) R-HSA-5607746 Reaction Name: PKC-delta is activated See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-751040 ( R-HSA-418597 ) R-HSA-751040 Reaction Name: PKC phosphorylates G alpha (z) See in Reactome R-HSA-8932284 () R-HSA-8932284 Reaction Name: PKC phosphorylates NFE2L2 See in Reactome R-HSA-8934446 ( R-HSA-1250196 ) R-HSA-8934446 Reaction Name: Activated PKC phosphorylates SHC1 See in Reactome R-HSA-8982703 ( R-HSA-418597 ) R-HSA-8982703 Reaction Name: PKC binds active G alpha (z) See in Reactome R-HSA-8982709 ( R-HSA-418597 ) R-HSA-8982709 Reaction Name: G-alpha(z):PKC dissociates to give phosphorylated G alpha (z) See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-9626817 ( R-HSA-5668599 ) R-HSA-9626817 Reaction Name: PKC phosphorylates NCF1 See in Reactome
MONDO:0019182	ADCY3	O60266	4.6.1.1	R-HSA-170670 R-HSA-170670 Reactome Name: Adenylate cyclase inhibitory pathway See in Reactome R-HSA-432040 R-HSA-432040 Reactome Name: Vasopressin regulates renal water homeostasis via Aquaporins See in Reactome R-HSA-163615 R-HSA-163615 Reactome Name: PKA activation See in Reactome R-HSA-170660 R-HSA-170660 Reactome Name: Adenylate cyclase activating pathway See in Reactome R-HSA-164378 R-HSA-164378 Reactome Name: PKA activation in glucagon signalling See in Reactome R-HSA-418597 R-HSA-418597 Reactome Name: G alpha (z) signalling events See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-163359 R-HSA-163359 Reactome Name: Glucagon signaling in metabolic regulation See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome R-HSA-381753 R-HSA-381753 Reactome Name: Olfactory Signaling Pathway See in Reactome	R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-111931 R-HSA-111931 Reactome Name: PKA-mediated phosphorylation of CREB See in Reactome R-HSA-977443 R-HSA-977443 Reactome Name: GABA receptor activation See in Reactome R-HSA-977444 R-HSA-977444 Reactome Name: GABA B receptor activation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-445717 R-HSA-445717 Reactome Name: Aquaporin-mediated transport See in Reactome R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome R-HSA-991365 R-HSA-991365 Reactome Name: Activation of GABAB receptors See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Transport of small molecules Metabolism Neuronal System Sensory Perception Signal Transduction	R-HSA-111930 ( R-HSA-163615; R-HSA-418594 ) R-HSA-111930 Reaction Name: Adenylate cyclase produces cAMP See in Reactome R-HSA-163617 ( R-HSA-163359; R-HSA-418555; R-HSA-432040 ) R-HSA-163617 Reaction Name: G alpha (s) activates adenylate cyclase See in Reactome R-HSA-164377 ( R-HSA-163359; R-HSA-164378; R-HSA-432040 ) R-HSA-164377 Reaction Name: Activated Adenylate cyclase catalyses cAMP synthesis See in Reactome R-HSA-170666 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170666 Reaction Name: Adenylate cyclase increases the GTPase activity of G alpha-olf See in Reactome R-HSA-170671 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170671 Reaction Name: G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex See in Reactome R-HSA-170672 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170672 Reaction Name: Galpha-olf:GTP binds to adenylate cyclase and activates it See in Reactome R-HSA-170674 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170674 Reaction Name: Dissociation of the Gi alpha:G olf complex See in Reactome R-HSA-170676 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170676 Reaction Name: Adenylate cyclase converts ATP into cyclic AMP See in Reactome R-HSA-170677 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170677 Reaction Name: The G alpha-olf:GDP:Adenylate cyclase complex dissociates See in Reactome R-HSA-170685 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170685 Reaction Name: Adenylaye cyclase increases the GTPase activity of G alpha-olf See in Reactome R-HSA-170686 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170686 Reaction Name: Adenylate cyclase increases the GTPase activity of Gi alpha See in Reactome R-HSA-392064 ( R-HSA-418597 ) R-HSA-392064 Reaction Name: G alpha (z) inhibits adenylate cyclase See in Reactome R-HSA-392129 ( R-HSA-418555; R-HSA-418594; R-HSA-418597 ) R-HSA-392129 Reaction Name: Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate See in Reactome R-HSA-392206 ( R-HSA-170670; R-HSA-418594 ) R-HSA-392206 Reaction Name: G alpha (i) inhibits adenylate cyclase See in Reactome R-HSA-5610727 ( R-HSA-5610787 ) R-HSA-5610727 Reaction Name: GPR161 promotes cAMP production in a G alpha(s)-dependent manner See in Reactome R-HSA-9712183 ( R-HSA-381753 ) R-HSA-9712183 Reaction Name: ADCY3:GNAL:GTP converts ATP to cAMP See in Reactome R-HSA-9712187 ( R-HSA-381753 ) R-HSA-9712187 Reaction Name: GNAL:GTP (G alpha-olf) binds ADCY3 See in Reactome
OMIM:619647	ADCY5	O95622	4.6.1.1	R-HSA-170670 R-HSA-170670 Reactome Name: Adenylate cyclase inhibitory pathway See in Reactome R-HSA-163615 R-HSA-163615 Reactome Name: PKA activation See in Reactome R-HSA-170660 R-HSA-170660 Reactome Name: Adenylate cyclase activating pathway See in Reactome R-HSA-400042 R-HSA-400042 Reactome Name: Adrenaline,noradrenaline inhibits insulin secretion See in Reactome R-HSA-164378 R-HSA-164378 Reactome Name: PKA activation in glucagon signalling See in Reactome R-HSA-418597 R-HSA-418597 Reactome Name: G alpha (z) signalling events See in Reactome R-HSA-381676 R-HSA-381676 Reactome Name: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-432040 R-HSA-432040 Reactome Name: Vasopressin regulates renal water homeostasis via Aquaporins See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome R-HSA-163359 R-HSA-163359 Reactome Name: Glucagon signaling in metabolic regulation See in Reactome	R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-111931 R-HSA-111931 Reactome Name: PKA-mediated phosphorylation of CREB See in Reactome R-HSA-977443 R-HSA-977443 Reactome Name: GABA receptor activation See in Reactome R-HSA-977444 R-HSA-977444 Reactome Name: GABA B receptor activation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-445717 R-HSA-445717 Reactome Name: Aquaporin-mediated transport See in Reactome R-HSA-991365 R-HSA-991365 Reactome Name: Activation of GABAB receptors See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Transport of small molecules Metabolism Neuronal System Signal Transduction	R-HSA-111930 ( R-HSA-163615; R-HSA-418594 ) R-HSA-111930 Reaction Name: Adenylate cyclase produces cAMP See in Reactome R-HSA-163617 ( R-HSA-163359; R-HSA-418555; R-HSA-432040 ) R-HSA-163617 Reaction Name: G alpha (s) activates adenylate cyclase See in Reactome R-HSA-164377 ( R-HSA-163359; R-HSA-164378; R-HSA-432040 ) R-HSA-164377 Reaction Name: Activated Adenylate cyclase catalyses cAMP synthesis See in Reactome R-HSA-170666 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170666 Reaction Name: Adenylate cyclase increases the GTPase activity of G alpha-olf See in Reactome R-HSA-170671 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170671 Reaction Name: G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex See in Reactome R-HSA-170672 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170672 Reaction Name: Galpha-olf:GTP binds to adenylate cyclase and activates it See in Reactome R-HSA-170674 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170674 Reaction Name: Dissociation of the Gi alpha:G olf complex See in Reactome R-HSA-170676 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170676 Reaction Name: Adenylate cyclase converts ATP into cyclic AMP See in Reactome R-HSA-170677 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170677 Reaction Name: The G alpha-olf:GDP:Adenylate cyclase complex dissociates See in Reactome R-HSA-170685 ( R-HSA-170660; R-HSA-418594 ) R-HSA-170685 Reaction Name: Adenylaye cyclase increases the GTPase activity of G alpha-olf See in Reactome R-HSA-170686 ( R-HSA-170670; R-HSA-418594 ) R-HSA-170686 Reaction Name: Adenylate cyclase increases the GTPase activity of Gi alpha See in Reactome R-HSA-381607 ( R-HSA-381676 ) R-HSA-381607 Reaction Name: Activated Adenylyl cyclase synthesizes cyclic AMP See in Reactome R-HSA-381704 ( R-HSA-163359; R-HSA-381676 ) R-HSA-381704 Reaction Name: G(s):GTP activates Adenylyl cyclase See in Reactome R-HSA-392064 ( R-HSA-418597 ) R-HSA-392064 Reaction Name: G alpha (z) inhibits adenylate cyclase See in Reactome R-HSA-392129 ( R-HSA-418555; R-HSA-418594; R-HSA-418597 ) R-HSA-392129 Reaction Name: Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate See in Reactome R-HSA-392206 ( R-HSA-170670; R-HSA-418594 ) R-HSA-392206 Reaction Name: G alpha (i) inhibits adenylate cyclase See in Reactome R-HSA-400097 ( R-HSA-400042 ) R-HSA-400097 Reaction Name: G-beta:G-gamma inhibits Adenylate cyclase See in Reactome R-HSA-5610727 ( R-HSA-5610787 ) R-HSA-5610727 Reaction Name: GPR161 promotes cAMP production in a G alpha(s)-dependent manner See in Reactome