DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-418457)

Number of enzymes:	4
Number of disease:	8
Number of reactomes:	4
Number of reactions:	3

Search results (Reactome ID: R-HSA-418457)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0011178	PDE2A	O00408	3.1.4.17	R-HSA-418457 R-HSA-418457 Reactome Name: cGMP effects See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome	R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-392154 R-HSA-392154 Reactome Name: Nitric oxide stimulates guanylate cyclase See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Hemostasis Signal Transduction	R-HSA-418456 ( R-HSA-418457 ) R-HSA-418456 Reaction Name: cGMP is degraded by PDEs See in Reactome R-HSA-418553 ( R-HSA-418555 ) R-HSA-418553 Reaction Name: cAMP degradation by Phosphodiesterases See in Reactome
MONDO:0012505	PDE11A	Q9HCR9	3.1.4.53 3.1.4.35	R-HSA-418457 R-HSA-418457 Reactome Name: cGMP effects See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome	R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-392154 R-HSA-392154 Reactome Name: Nitric oxide stimulates guanylate cyclase See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Hemostasis Signal Transduction	R-HSA-418456 ( R-HSA-418457 ) R-HSA-418456 Reaction Name: cGMP is degraded by PDEs See in Reactome R-HSA-418553 ( R-HSA-418555 ) R-HSA-418553 Reaction Name: cAMP degradation by Phosphodiesterases See in Reactome
MONDO:0014187	PRKG1	Q13976	2.7.11.12	R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-418457 R-HSA-418457 Reactome Name: cGMP effects See in Reactome R-HSA-392517 R-HSA-392517 Reactome Name: Rap1 signalling See in Reactome	R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-392154 R-HSA-392154 Reactome Name: Nitric oxide stimulates guanylate cyclase See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Hemostasis Signal Transduction	R-HSA-4551453 ( R-HSA-4086398 ) R-HSA-4551453 Reaction Name: PRKG is activated by binding to high levels of cGMP in the absence of WNT signaling See in Reactome
MONDO:0014834	PDE10A	Q9Y233	3.1.4.17	R-HSA-418457 R-HSA-418457 Reactome Name: cGMP effects See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome	R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-392154 R-HSA-392154 Reactome Name: Nitric oxide stimulates guanylate cyclase See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Hemostasis Signal Transduction	R-HSA-418456 ( R-HSA-418457 ) R-HSA-418456 Reaction Name: cGMP is degraded by PDEs See in Reactome R-HSA-418553 ( R-HSA-418555 ) R-HSA-418553 Reaction Name: cAMP degradation by Phosphodiesterases See in Reactome
MONDO:0014835	PDE10A	Q9Y233	3.1.4.17	R-HSA-418457 R-HSA-418457 Reactome Name: cGMP effects See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome	R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-392154 R-HSA-392154 Reactome Name: Nitric oxide stimulates guanylate cyclase See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Hemostasis Signal Transduction	R-HSA-418456 ( R-HSA-418457 ) R-HSA-418456 Reaction Name: cGMP is degraded by PDEs See in Reactome R-HSA-418553 ( R-HSA-418555 ) R-HSA-418553 Reaction Name: cAMP degradation by Phosphodiesterases See in Reactome
MONDO:0030900	PDE2A	O00408	3.1.4.17	R-HSA-418457 R-HSA-418457 Reactome Name: cGMP effects See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome	R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-392154 R-HSA-392154 Reactome Name: Nitric oxide stimulates guanylate cyclase See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Hemostasis Signal Transduction	R-HSA-418456 ( R-HSA-418457 ) R-HSA-418456 Reaction Name: cGMP is degraded by PDEs See in Reactome R-HSA-418553 ( R-HSA-418555 ) R-HSA-418553 Reaction Name: cAMP degradation by Phosphodiesterases See in Reactome
MONDO:0044332	PDE10A	Q9Y233	3.1.4.17	R-HSA-418457 R-HSA-418457 Reactome Name: cGMP effects See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome	R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-392154 R-HSA-392154 Reactome Name: Nitric oxide stimulates guanylate cyclase See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Hemostasis Signal Transduction	R-HSA-418456 ( R-HSA-418457 ) R-HSA-418456 Reaction Name: cGMP is degraded by PDEs See in Reactome R-HSA-418553 ( R-HSA-418555 ) R-HSA-418553 Reaction Name: cAMP degradation by Phosphodiesterases See in Reactome
MONDO:0044637	PDE10A	Q9Y233	3.1.4.17	R-HSA-418457 R-HSA-418457 Reactome Name: cGMP effects See in Reactome R-HSA-418555 R-HSA-418555 Reactome Name: G alpha (s) signalling events See in Reactome	R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-392154 R-HSA-392154 Reactome Name: Nitric oxide stimulates guanylate cyclase See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Hemostasis Signal Transduction	R-HSA-418456 ( R-HSA-418457 ) R-HSA-418456 Reaction Name: cGMP is degraded by PDEs See in Reactome R-HSA-418553 ( R-HSA-418555 ) R-HSA-418553 Reaction Name: cAMP degradation by Phosphodiesterases See in Reactome