DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-4090294)

Number of enzymes:	2
Number of disease:	2
Number of reactomes:	12
Number of reactions:	40

Search results (Reactome ID: R-HSA-4090294)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0010886	HDAC4	P56524	3.5.1.98	R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-4551638 R-HSA-4551638 Reactome Name: SUMOylation of chromatin organization proteins See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-8941284 R-HSA-8941284 Reactome Name: RUNX2 regulates chondrocyte maturation See in Reactome R-HSA-4090294 R-HSA-4090294 Reactome Name: SUMOylation of intracellular receptors See in Reactome R-HSA-350054 R-HSA-350054 Reactome Name: Notch-HLH transcription pathway See in Reactome	R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome	Gene expression (Transcription) Metabolism of proteins Signal Transduction	R-HSA-1912388 ( R-HSA-2122947 ) R-HSA-1912388 Reaction Name: NICD1 displaces co-repressor complex from RBPJ (CSL) See in Reactome R-HSA-350058 ( R-HSA-350054 ) R-HSA-350058 Reaction Name: Formation of CSL NCOR corepressor complex See in Reactome R-HSA-4615872 ( R-HSA-4551638 ) R-HSA-4615872 Reaction Name: RANBP2 SUMOylates HDAC4 with SUMO1 See in Reactome R-HSA-4615987 ( R-HSA-4551638 ) R-HSA-4615987 Reaction Name: RANBP2 SUMOylates HDAC4 with SUMO2,3 See in Reactome R-HSA-4720432 ( R-HSA-4090294 ) R-HSA-4720432 Reaction Name: HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 See in Reactome R-HSA-4720446 ( R-HSA-4090294 ) R-HSA-4720446 Reaction Name: HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 See in Reactome R-HSA-8952062 ( R-HSA-8951936 ) R-HSA-8952062 Reaction Name: CCND1 recruits HDAC4 to RUNX3 See in Reactome R-HSA-8952069 ( R-HSA-8951936 ) R-HSA-8952069 Reaction Name: HDAC4 deacetylates RUNX3 See in Reactome R-HSA-9008326 ( R-HSA-8941284 ) R-HSA-9008326 Reaction Name: RUNX2 binds HDAC4 See in Reactome
MONDO:0019005	PIAS1	O75925	2.3.2.-	R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-3232118 R-HSA-3232118 Reactome Name: SUMOylation of transcription factors See in Reactome R-HSA-3232142 R-HSA-3232142 Reactome Name: SUMOylation of ubiquitinylation proteins See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-4551638 R-HSA-4551638 Reactome Name: SUMOylation of chromatin organization proteins See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-3108214 R-HSA-3108214 Reactome Name: SUMOylation of DNA damage response and repair proteins See in Reactome R-HSA-4090294 R-HSA-4090294 Reactome Name: SUMOylation of intracellular receptors See in Reactome	R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome	Immune System Metabolism of proteins DNA Repair	R-HSA-2997616 ( R-HSA-3108214 ) R-HSA-2997616 Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO2,3 See in Reactome R-HSA-2997709 ( R-HSA-3108214 ) R-HSA-2997709 Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO1 See in Reactome R-HSA-3000434 ( R-HSA-3232142 ) R-HSA-3000434 Reaction Name: PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 See in Reactome R-HSA-3247493 ( R-HSA-3232118 ) R-HSA-3247493 Reaction Name: PIAS1 SUMOylates SP3 with SUMO1 See in Reactome R-HSA-3465545 ( R-HSA-3232118 ) R-HSA-3465545 Reaction Name: PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 See in Reactome R-HSA-3900194 ( R-HSA-3899300 ) R-HSA-3900194 Reaction Name: PIAS1 SUMOylates DDX5 with SUMO2 See in Reactome R-HSA-3968414 ( R-HSA-3232118 ) R-HSA-3968414 Reaction Name: UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 See in Reactome R-HSA-4085347 ( R-HSA-3899300 ) R-HSA-4085347 Reaction Name: PIAS1 SUMOylates SAFB with SUMO1 See in Reactome R-HSA-4085372 ( R-HSA-3899300 ) R-HSA-4085372 Reaction Name: PIAS1 SUMOylates SAFB with SUMO2,3 See in Reactome R-HSA-4086036 ( R-HSA-3899300 ) R-HSA-4086036 Reaction Name: PIAS1,3 SUMOylate NRIP1 with SUMO1 See in Reactome R-HSA-4090281 ( R-HSA-3232118 ) R-HSA-4090281 Reaction Name: PIAS1,2-1 SUMOylate HIC1 with SUMO1 See in Reactome R-HSA-4090288 ( R-HSA-3899300 ) R-HSA-4090288 Reaction Name: PIAS1,3 SUMOylate MBD1 with SUMO1 See in Reactome R-HSA-4090390 ( R-HSA-4090294 ) R-HSA-4090390 Reaction Name: PIAS1,2-1 SUMOylates AR with SUMO1 See in Reactome R-HSA-4090408 ( R-HSA-4090294 ) R-HSA-4090408 Reaction Name: PIAS1,3 SUMOylate ESR1 with SUMO1 See in Reactome R-HSA-4341016 ( R-HSA-4090294 ) R-HSA-4341016 Reaction Name: PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 See in Reactome R-HSA-4546385 ( R-HSA-4090294 ) R-HSA-4546385 Reaction Name: PIAS1,3 SUMOylates NR5A1 with SUMO2 See in Reactome R-HSA-4546386 ( R-HSA-4090294 ) R-HSA-4546386 Reaction Name: PIAS1,3 SUMOylates NR5A1 with SUMO1 See in Reactome R-HSA-4568848 ( R-HSA-3108214 ) R-HSA-4568848 Reaction Name: PIAS1,2-1 SUMOylates XRCC4 with SUMO1 See in Reactome R-HSA-4615839 ( R-HSA-4551638 ) R-HSA-4615839 Reaction Name: PIAS1 SUMOylates SATB1 with SUMO2,3 See in Reactome R-HSA-4615900 ( R-HSA-4551638 ) R-HSA-4615900 Reaction Name: PIAS1 SUMOylates SATB2 with SUMO3 See in Reactome R-HSA-4615905 ( R-HSA-4551638 ) R-HSA-4615905 Reaction Name: PIAS1 SUMOylates SATB1 with SUMO1 See in Reactome R-HSA-4717461 ( R-HSA-4090294 ) R-HSA-4717461 Reaction Name: PIAS1,2-2 SUMOylate PPARG with SUMO1 See in Reactome R-HSA-4717521 ( R-HSA-4090294 ) R-HSA-4717521 Reaction Name: PIAS1 SUMOylates NR2C1 (TR2) See in Reactome R-HSA-4719424 ( R-HSA-4090294 ) R-HSA-4719424 Reaction Name: PIAS1 SUMOylates THRB with SUMO1. See in Reactome R-HSA-4719448 ( R-HSA-4090294 ) R-HSA-4719448 Reaction Name: PIAS1 SUMOylates THRB with SUMO3 See in Reactome R-HSA-4755494 ( R-HSA-4090294 ) R-HSA-4755494 Reaction Name: PIAS1,2-1 SUMOylate NR5A2 with SUMO1 See in Reactome R-HSA-5228521 ( R-HSA-3899300 ) R-HSA-5228521 Reaction Name: PIAS1,4 SUMOylate CASP8AP2 with SUMO1 See in Reactome R-HSA-6790454 ( R-HSA-5696395 ) R-HSA-6790454 Reaction Name: SUMOylation of XPC See in Reactome R-HSA-6804468 ( R-HSA-3232118 ) R-HSA-6804468 Reaction Name: PIAS1 SUMOylates SP3 with SUMO2 See in Reactome R-HSA-6804485 ( R-HSA-4551638 ) R-HSA-6804485 Reaction Name: PIAS1 SUMOylates L3MBTL2 with SUMO2 See in Reactome R-HSA-877281 ( R-HSA-877312 ) R-HSA-877281 Reaction Name: PIAS1 binds p-STAT1 dimer See in Reactome