DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-4085001)

Number of enzymes:	7
Number of disease:	15
Number of reactomes:	10
Number of reactions:	22

Search results (Reactome ID: R-HSA-4085001)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009260	GLB1	P16278	3.2.1.23	R-HSA-2022857 R-HSA-2022857 Reactome Name: Keratan sulfate degradation See in Reactome R-HSA-2024096 R-HSA-2024096 Reactome Name: HS-GAG degradation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-4085001 R-HSA-4085001 Reactome Name: Sialic acid metabolism See in Reactome	R-HSA-446219 R-HSA-446219 Reactome Name: Synthesis of substrates in N-glycan biosythesis See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1638091 R-HSA-1638091 Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome	Immune System Metabolism of proteins Metabolism	R-HSA-1605624 ( R-HSA-1660662 ) R-HSA-1605624 Reaction Name: Beta-galactosidase hydrolyses GM1 to GM2 See in Reactome R-HSA-1605724 ( R-HSA-1660662 ) R-HSA-1605724 Reaction Name: Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) See in Reactome R-HSA-1606312 ( R-HSA-1660662 ) R-HSA-1606312 Reaction Name: Beta-galactosidase can also hydrolyse globosides to form cerebrosides See in Reactome R-HSA-1630306 ( R-HSA-2022857 ) R-HSA-1630306 Reaction Name: GLB1 hydrolyses a glycosaminoglycan See in Reactome R-HSA-2090079 ( R-HSA-2024096 ) R-HSA-2090079 Reaction Name: GLB1 hydrolyses linker chain(2) See in Reactome R-HSA-4084999 ( R-HSA-4085001 ) R-HSA-4084999 Reaction Name: NEU1 hydrolyses Neu5Ac from glycoconjugates See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-9638120 ( R-HSA-4085001 ) R-HSA-9638120 Reaction Name: NEU4 hydrolyses Neu5Ac from glycoconjugates See in Reactome
MONDO:0009261	GLB1	P16278	3.2.1.23	R-HSA-2022857 R-HSA-2022857 Reactome Name: Keratan sulfate degradation See in Reactome R-HSA-2024096 R-HSA-2024096 Reactome Name: HS-GAG degradation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-4085001 R-HSA-4085001 Reactome Name: Sialic acid metabolism See in Reactome	R-HSA-446219 R-HSA-446219 Reactome Name: Synthesis of substrates in N-glycan biosythesis See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1638091 R-HSA-1638091 Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome	Immune System Metabolism of proteins Metabolism	R-HSA-1605624 ( R-HSA-1660662 ) R-HSA-1605624 Reaction Name: Beta-galactosidase hydrolyses GM1 to GM2 See in Reactome R-HSA-1605724 ( R-HSA-1660662 ) R-HSA-1605724 Reaction Name: Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) See in Reactome R-HSA-1606312 ( R-HSA-1660662 ) R-HSA-1606312 Reaction Name: Beta-galactosidase can also hydrolyse globosides to form cerebrosides See in Reactome R-HSA-1630306 ( R-HSA-2022857 ) R-HSA-1630306 Reaction Name: GLB1 hydrolyses a glycosaminoglycan See in Reactome R-HSA-2090079 ( R-HSA-2024096 ) R-HSA-2090079 Reaction Name: GLB1 hydrolyses linker chain(2) See in Reactome R-HSA-4084999 ( R-HSA-4085001 ) R-HSA-4084999 Reaction Name: NEU1 hydrolyses Neu5Ac from glycoconjugates See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-9638120 ( R-HSA-4085001 ) R-HSA-9638120 Reaction Name: NEU4 hydrolyses Neu5Ac from glycoconjugates See in Reactome
MONDO:0009262	GLB1	P16278	3.2.1.23	R-HSA-2022857 R-HSA-2022857 Reactome Name: Keratan sulfate degradation See in Reactome R-HSA-2024096 R-HSA-2024096 Reactome Name: HS-GAG degradation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-4085001 R-HSA-4085001 Reactome Name: Sialic acid metabolism See in Reactome	R-HSA-446219 R-HSA-446219 Reactome Name: Synthesis of substrates in N-glycan biosythesis See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1638091 R-HSA-1638091 Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome	Immune System Metabolism of proteins Metabolism	R-HSA-1605624 ( R-HSA-1660662 ) R-HSA-1605624 Reaction Name: Beta-galactosidase hydrolyses GM1 to GM2 See in Reactome R-HSA-1605724 ( R-HSA-1660662 ) R-HSA-1605724 Reaction Name: Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) See in Reactome R-HSA-1606312 ( R-HSA-1660662 ) R-HSA-1606312 Reaction Name: Beta-galactosidase can also hydrolyse globosides to form cerebrosides See in Reactome R-HSA-1630306 ( R-HSA-2022857 ) R-HSA-1630306 Reaction Name: GLB1 hydrolyses a glycosaminoglycan See in Reactome R-HSA-2090079 ( R-HSA-2024096 ) R-HSA-2090079 Reaction Name: GLB1 hydrolyses linker chain(2) See in Reactome R-HSA-4084999 ( R-HSA-4085001 ) R-HSA-4084999 Reaction Name: NEU1 hydrolyses Neu5Ac from glycoconjugates See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-9638120 ( R-HSA-4085001 ) R-HSA-9638120 Reaction Name: NEU4 hydrolyses Neu5Ac from glycoconjugates See in Reactome
MONDO:0009660	GLB1	P16278	3.2.1.23	R-HSA-2022857 R-HSA-2022857 Reactome Name: Keratan sulfate degradation See in Reactome R-HSA-2024096 R-HSA-2024096 Reactome Name: HS-GAG degradation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-4085001 R-HSA-4085001 Reactome Name: Sialic acid metabolism See in Reactome	R-HSA-446219 R-HSA-446219 Reactome Name: Synthesis of substrates in N-glycan biosythesis See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1638091 R-HSA-1638091 Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome	Immune System Metabolism of proteins Metabolism	R-HSA-1605624 ( R-HSA-1660662 ) R-HSA-1605624 Reaction Name: Beta-galactosidase hydrolyses GM1 to GM2 See in Reactome R-HSA-1605724 ( R-HSA-1660662 ) R-HSA-1605724 Reaction Name: Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) See in Reactome R-HSA-1606312 ( R-HSA-1660662 ) R-HSA-1606312 Reaction Name: Beta-galactosidase can also hydrolyse globosides to form cerebrosides See in Reactome R-HSA-1630306 ( R-HSA-2022857 ) R-HSA-1630306 Reaction Name: GLB1 hydrolyses a glycosaminoglycan See in Reactome R-HSA-2090079 ( R-HSA-2024096 ) R-HSA-2090079 Reaction Name: GLB1 hydrolyses linker chain(2) See in Reactome R-HSA-4084999 ( R-HSA-4085001 ) R-HSA-4084999 Reaction Name: NEU1 hydrolyses Neu5Ac from glycoconjugates See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-9638120 ( R-HSA-4085001 ) R-HSA-9638120 Reaction Name: NEU4 hydrolyses Neu5Ac from glycoconjugates See in Reactome
MONDO:0009737	CTSA	P10619	3.4.16.5	R-HSA-4085001 R-HSA-4085001 Reactome Name: Sialic acid metabolism See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2132295 R-HSA-2132295 Reactome Name: MHC class II antigen presentation See in Reactome	R-HSA-446219 R-HSA-446219 Reactome Name: Synthesis of substrates in N-glycan biosythesis See in Reactome R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome	Immune System Metabolism of proteins Metabolism	R-HSA-1605724 ( R-HSA-1660662 ) R-HSA-1605724 Reaction Name: Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) See in Reactome R-HSA-2130349 ( R-HSA-2132295 ) R-HSA-2130349 Reaction Name: Generation of CLIP from lip10 See in Reactome R-HSA-2130504 ( R-HSA-2132295 ) R-HSA-2130504 Reaction Name: Cleavage of lip22 to lip10 See in Reactome R-HSA-2130706 ( R-HSA-2132295 ) R-HSA-2130706 Reaction Name: MHC class II antigen processing See in Reactome R-HSA-4084999 ( R-HSA-4085001 ) R-HSA-4084999 Reaction Name: NEU1 hydrolyses Neu5Ac from glycoconjugates See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-9638120 ( R-HSA-4085001 ) R-HSA-9638120 Reaction Name: NEU4 hydrolyses Neu5Ac from glycoconjugates See in Reactome
MONDO:0010028	GNE	Q9Y223	3.2.1.183 2.7.1.60	R-HSA-4085001 R-HSA-4085001 Reactome Name: Sialic acid metabolism See in Reactome	R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-446219 R-HSA-446219 Reactome Name: Synthesis of substrates in N-glycan biosythesis See in Reactome R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Metabolism of proteins	R-HSA-4085021 ( R-HSA-4085001 ) R-HSA-4085021 Reaction Name: GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP See in Reactome R-HSA-4085028 ( R-HSA-4085001 ) R-HSA-4085028 Reaction Name: GNE phosphorylates ManNAc to ManNAc-6-P See in Reactome
MONDO:0011603	GNE	Q9Y223	3.2.1.183 2.7.1.60	R-HSA-4085001 R-HSA-4085001 Reactome Name: Sialic acid metabolism See in Reactome	R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-446219 R-HSA-446219 Reactome Name: Synthesis of substrates in N-glycan biosythesis See in Reactome R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Metabolism of proteins	R-HSA-4085021 ( R-HSA-4085001 ) R-HSA-4085021 Reaction Name: GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP See in Reactome R-HSA-4085028 ( R-HSA-4085001 ) R-HSA-4085028 Reaction Name: GNE phosphorylates ManNAc to ManNAc-6-P See in Reactome
MONDO:0012495	NANS	Q9NR45	2.5.1.57 2.5.1.56	R-HSA-4085001 R-HSA-4085001 Reactome Name: Sialic acid metabolism See in Reactome	R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-446219 R-HSA-446219 Reactome Name: Synthesis of substrates in N-glycan biosythesis See in Reactome R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Metabolism of proteins	R-HSA-4084976 ( R-HSA-4085001 ) R-HSA-4084976 Reaction Name: NANS converts ManNAc-6-P to Neu5Ac-9-P See in Reactome
MONDO:0012612	ST3GAL3	Q11203	2.4.99.6	R-HSA-1912420 R-HSA-1912420 Reactome Name: Pre-NOTCH Processing in Golgi See in Reactome R-HSA-4085001 R-HSA-4085001 Reactome Name: Sialic acid metabolism See in Reactome R-HSA-2022854 R-HSA-2022854 Reactome Name: Keratan sulfate biosynthesis See in Reactome R-HSA-9037629 R-HSA-9037629 Reactome Name: Lewis blood group biosynthesis See in Reactome R-HSA-977068 R-HSA-977068 Reactome Name: Termination of O-glycan biosynthesis See in Reactome	R-HSA-446219 R-HSA-446219 Reactome Name: Synthesis of substrates in N-glycan biosythesis See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-9033658 R-HSA-9033658 Reactome Name: Blood group systems biosynthesis See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5173105 R-HSA-5173105 Reactome Name: O-linked glycosylation See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-913709 R-HSA-913709 Reactome Name: O-linked glycosylation of mucins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome	Metabolism of proteins Metabolism Signal Transduction	R-HSA-1912378 ( R-HSA-1912420 ) R-HSA-1912378 Reaction Name: Sialylation of Pre-NOTCH See in Reactome R-HSA-2046285 ( R-HSA-2022854 ) R-HSA-2046285 Reaction Name: The keratan chain can be capped by N-acetylneuraminic acid See in Reactome R-HSA-4084984 ( R-HSA-4085001 ) R-HSA-4084984 Reaction Name: ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) See in Reactome R-HSA-9603987 ( R-HSA-9037629 ) R-HSA-9603987 Reaction Name: ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG See in Reactome R-HSA-9605600 ( R-HSA-9037629 ) R-HSA-9605600 Reaction Name: ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG See in Reactome R-HSA-981497 ( R-HSA-977068 ) R-HSA-981497 Reaction Name: ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position See in Reactome
MONDO:0014003	ST3GAL3	Q11203	2.4.99.6	R-HSA-1912420 R-HSA-1912420 Reactome Name: Pre-NOTCH Processing in Golgi See in Reactome R-HSA-4085001 R-HSA-4085001 Reactome Name: Sialic acid metabolism See in Reactome R-HSA-2022854 R-HSA-2022854 Reactome Name: Keratan sulfate biosynthesis See in Reactome R-HSA-9037629 R-HSA-9037629 Reactome Name: Lewis blood group biosynthesis See in Reactome R-HSA-977068 R-HSA-977068 Reactome Name: Termination of O-glycan biosynthesis See in Reactome	R-HSA-446219 R-HSA-446219 Reactome Name: Synthesis of substrates in N-glycan biosythesis See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-9033658 R-HSA-9033658 Reactome Name: Blood group systems biosynthesis See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5173105 R-HSA-5173105 Reactome Name: O-linked glycosylation See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-913709 R-HSA-913709 Reactome Name: O-linked glycosylation of mucins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome	Metabolism of proteins Metabolism Signal Transduction	R-HSA-1912378 ( R-HSA-1912420 ) R-HSA-1912378 Reaction Name: Sialylation of Pre-NOTCH See in Reactome R-HSA-2046285 ( R-HSA-2022854 ) R-HSA-2046285 Reaction Name: The keratan chain can be capped by N-acetylneuraminic acid See in Reactome R-HSA-4084984 ( R-HSA-4085001 ) R-HSA-4084984 Reaction Name: ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) See in Reactome R-HSA-9603987 ( R-HSA-9037629 ) R-HSA-9603987 Reaction Name: ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG See in Reactome R-HSA-9605600 ( R-HSA-9037629 ) R-HSA-9605600 Reaction Name: ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG See in Reactome R-HSA-981497 ( R-HSA-977068 ) R-HSA-981497 Reaction Name: ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position See in Reactome
MONDO:0014518	GNE	Q9Y223	3.2.1.183 2.7.1.60	R-HSA-4085001 R-HSA-4085001 Reactome Name: Sialic acid metabolism See in Reactome	R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-446219 R-HSA-446219 Reactome Name: Synthesis of substrates in N-glycan biosythesis See in Reactome R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Metabolism of proteins	R-HSA-4085021 ( R-HSA-4085001 ) R-HSA-4085021 Reaction Name: GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP See in Reactome R-HSA-4085028 ( R-HSA-4085001 ) R-HSA-4085028 Reaction Name: GNE phosphorylates ManNAc to ManNAc-6-P See in Reactome
MONDO:0018274	ST3GAL5	Q9UNP4	2.4.99.9	R-HSA-4085001 R-HSA-4085001 Reactome Name: Sialic acid metabolism See in Reactome	R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-446219 R-HSA-446219 Reactome Name: Synthesis of substrates in N-glycan biosythesis See in Reactome R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Metabolism of proteins	R-HSA-4084984 ( R-HSA-4085001 ) R-HSA-4084984 Reaction Name: ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) See in Reactome
MONDO:0019346	NEU1	Q99519	3.2.1.18	R-HSA-4085001 R-HSA-4085001 Reactome Name: Sialic acid metabolism See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome	R-HSA-446219 R-HSA-446219 Reactome Name: Synthesis of substrates in N-glycan biosythesis See in Reactome R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Immune System Metabolism of proteins Metabolism	R-HSA-1605724 ( R-HSA-1660662 ) R-HSA-1605724 Reaction Name: Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) See in Reactome R-HSA-4084999 ( R-HSA-4085001 ) R-HSA-4084999 Reaction Name: NEU1 hydrolyses Neu5Ac from glycoconjugates See in Reactome R-HSA-6798749 ( R-HSA-6798695 ) R-HSA-6798749 Reaction Name: Exocytosis of specific granule lumen proteins See in Reactome
MONDO:0019681	NEU1	Q99519	3.2.1.18	R-HSA-4085001 R-HSA-4085001 Reactome Name: Sialic acid metabolism See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome	R-HSA-446219 R-HSA-446219 Reactome Name: Synthesis of substrates in N-glycan biosythesis See in Reactome R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Immune System Metabolism of proteins Metabolism	R-HSA-1605724 ( R-HSA-1660662 ) R-HSA-1605724 Reaction Name: Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) See in Reactome R-HSA-4084999 ( R-HSA-4085001 ) R-HSA-4084999 Reaction Name: NEU1 hydrolyses Neu5Ac from glycoconjugates See in Reactome R-HSA-6798749 ( R-HSA-6798695 ) R-HSA-6798749 Reaction Name: Exocytosis of specific granule lumen proteins See in Reactome
MONDO:0019682	NEU1	Q99519	3.2.1.18	R-HSA-4085001 R-HSA-4085001 Reactome Name: Sialic acid metabolism See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome	R-HSA-446219 R-HSA-446219 Reactome Name: Synthesis of substrates in N-glycan biosythesis See in Reactome R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Immune System Metabolism of proteins Metabolism	R-HSA-1605724 ( R-HSA-1660662 ) R-HSA-1605724 Reaction Name: Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) See in Reactome R-HSA-4084999 ( R-HSA-4085001 ) R-HSA-4084999 Reaction Name: NEU1 hydrolyses Neu5Ac from glycoconjugates See in Reactome R-HSA-6798749 ( R-HSA-6798695 ) R-HSA-6798749 Reaction Name: Exocytosis of specific granule lumen proteins See in Reactome