MONDO:0005036 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-2682334;
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-2682334;
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-2682334;
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-2682334;
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-2682334;
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0005061 |
EPHA5 |
P54756 |
2.7.10.1
|
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-2682334
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
|
R-HSA-422475
R-HSA-9675108
R-HSA-1266738
|
Developmental Biology
|
R-HSA-3928578
(
R-HSA-2682334
)
R-HSA-3928578
Reaction Name: EPH receptors autophosphorylate
See in Reactome
R-HSA-3928584
(
R-HSA-2682334
)
R-HSA-3928591
(
R-HSA-2682334
)
R-HSA-3928597
(
R-HSA-2682334
)
R-HSA-3928602
(
R-HSA-2682334;
R-HSA-3928663
)
R-HSA-3928604
(
R-HSA-2682334;
R-HSA-3928665
)
R-HSA-3928607
(
R-HSA-2682334;
R-HSA-3928665
)
R-HSA-3928628
(
R-HSA-2682334;
R-HSA-3928665
)
R-HSA-3928628
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928642
(
R-HSA-2682334;
R-HSA-3928665
)
R-HSA-3928642
Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928646
(
R-HSA-2682334
)
R-HSA-3928648
(
R-HSA-2682334;
R-HSA-3928663
)
R-HSA-3928651
(
R-HSA-2682334;
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-3928660
(
R-HSA-2682334;
R-HSA-3928665
)
R-HSA-4093327
(
R-HSA-2682334;
R-HSA-3928665
)
|
MONDO:0005061 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-2682334;
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-2682334;
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-2682334;
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-2682334;
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-2682334;
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0005138 |
ROCK1 |
Q13464 |
2.7.11.1
|
R-HSA-4420097
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-111465
R-HSA-111465
Reactome Name: Apoptotic cleavage of cellular proteins
See in Reactome
R-HSA-9696264
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-9013026
R-HSA-9013407
R-HSA-6798695
R-HSA-9013422
R-HSA-8980692
|
R-HSA-162582
R-HSA-195258
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-400685
R-HSA-9012999
R-HSA-194138
R-HSA-388396
R-HSA-109581
R-HSA-168256
R-HSA-194315
R-HSA-9675108
R-HSA-75153
R-HSA-9706574
R-HSA-5357801
R-HSA-168249
R-HSA-372790
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-2682334
R-HSA-1266738
|
Signal Transduction
Immune System
Programmed Cell Death
Developmental Biology
|
R-HSA-201611
(
R-HSA-111465
)
R-HSA-201611
Reaction Name: Caspase-mediated cleavage of Rock-1
See in Reactome
R-HSA-3928576
(
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-3928662
)
R-HSA-3928616
(
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013024
(
R-HSA-9013026
)
R-HSA-9013024
Reaction Name: RHOB binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9018778
(
R-HSA-9013422
)
R-HSA-9018778
Reaction Name: RHOBTB1 binds interacting proteins at the endosome membrane
See in Reactome
R-HSA-9680443
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-9696268
(
R-HSA-9696264
)
|
MONDO:0005298 |
MONDO:0005298
Disease Name: osteoporosis
OMIM id: OMIM:166710
All associated enzymes in DAR:
SRC
. The disease is also associated to other non-enzyme proteins (not in DAR).
SRC |
P12931 |
2.7.10.2
|
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-171007
R-HSA-428542
R-HSA-428542
Reactome Name: Regulation of commissural axon pathfinding by SLIT and ROBO
See in Reactome
R-HSA-418594
R-HSA-8940973
R-HSA-8940973
Reactome Name: RUNX2 regulates osteoblast differentiation
See in Reactome
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-437239
R-HSA-418592
R-HSA-418592
Reactome Name: ADP signalling through P2Y purinoceptor 1
See in Reactome
R-HSA-430116
R-HSA-430116
Reactome Name: GP1b-IX-V activation signalling
See in Reactome
R-HSA-5663220
R-HSA-186763
R-HSA-180292
R-HSA-8941858
R-HSA-8941858
Reactome Name: Regulation of RUNX3 expression and activity
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-418555
R-HSA-5673000
R-HSA-9032500
R-HSA-9032500
Reactome Name: Activated NTRK2 signals through FYN
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-8934903
R-HSA-8853659
R-HSA-372708
R-HSA-372708
Reactome Name: p130Cas linkage to MAPK signaling for integrins
See in Reactome
R-HSA-389356
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-4420097
R-HSA-1433559
R-HSA-2029481
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-1433557
R-HSA-9620244
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-5607764
R-HSA-5674135
R-HSA-8874081
R-HSA-1253288
R-HSA-1253288
Reactome Name: Downregulation of ERBB4 signaling
See in Reactome
R-HSA-2682334
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-177929
R-HSA-1251985
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-354194
R-HSA-354194
Reactome Name: GRB2:SOS provides linkage to MAPK signaling for Integrins
See in Reactome
R-HSA-3928664
R-HSA-456926
R-HSA-456926
Reactome Name: Thrombin signalling through proteinase activated receptors (PARs)
See in Reactome
R-HSA-354192
R-HSA-201556
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-191650
R-HSA-191650
Reactome Name: Regulation of gap junction activity
See in Reactome
R-HSA-9013420
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-1227986
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-376176
R-HSA-9012999
R-HSA-8941326
R-HSA-8941326
Reactome Name: RUNX2 regulates bone development
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-195258
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-1640170
R-HSA-373760
R-HSA-5684996
R-HSA-1280218
R-HSA-1266738
R-HSA-5673001
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-9612973
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-5205647
R-HSA-388396
R-HSA-112316
R-HSA-162582
R-HSA-8875878
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-9675108
R-HSA-168249
R-HSA-9663891
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-392518
R-HSA-8939211
R-HSA-157858
R-HSA-157858
Reactome Name: Gap junction trafficking and regulation
See in Reactome
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-1236394
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-5653656
R-HSA-1632852
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-73857
R-HSA-5654736
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-9034015
R-HSA-186797
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-167044
R-HSA-373752
|
Immune System
Cell-Cell communication
Cell Cycle
Developmental Biology
Autophagy
Gene expression (Transcription)
Neuronal System
Signal Transduction
Vesicle-mediated transport
Hemostasis
|
R-HSA-1252013
(
R-HSA-1251985
)
R-HSA-1252013
Reaction Name: Translocation of ERBB4s80 to the nucleus
See in Reactome
R-HSA-177923
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-186819
(
R-HSA-186763
)
R-HSA-186819
Reaction Name: SH2 domain of Src binds to the active receptor
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-354066
(
R-HSA-354192
)
R-HSA-354066
Reaction Name: Translocation of PTK2 to Focal complexes
See in Reactome
R-HSA-354073
(
R-HSA-354192
)
R-HSA-354073
Reaction Name: Autophosphorylation of PTK2 at Y397
See in Reactome
R-HSA-354077
(
R-HSA-354192
)
R-HSA-354077
Reaction Name: Integrin alphaIIb beta3 activation
See in Reactome
R-HSA-354087
(
R-HSA-354192;
R-HSA-354194
)
R-HSA-354124
(
R-HSA-354192
)
R-HSA-354124
Reaction Name: Phosphorylation of pPTK2 by SRC
See in Reactome
R-HSA-354149
(
R-HSA-354192
)
R-HSA-354149
Reaction Name: Interaction of integrin alphaIIb beta3 with Fibrinogen
See in Reactome
R-HSA-354165
(
R-HSA-354192;
R-HSA-354194
)
R-HSA-354165
Reaction Name: Interaction of SOS with GRB2 bound to FADK1
See in Reactome
R-HSA-372693
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372693
Reaction Name: Phosphorylation of BCAR1 by SRC-PTK2 complex
See in Reactome
R-HSA-372697
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372705
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372705
Reaction Name: Recruitment of BCAR1 to PTK2 complex
See in Reactome
R-HSA-373716
(
R-HSA-418885
)
R-HSA-374701
(
R-HSA-418885
)
R-HSA-377640
(
R-HSA-354192
)
R-HSA-377641
(
R-HSA-354192
)
R-HSA-377641
Reaction Name: Clustering of Integrin alphaIIb beta3 complexes
See in Reactome
R-HSA-377643
(
R-HSA-354192
)
R-HSA-377643
Reaction Name: Dephosphorylation of inactive SRC by PTPB1
See in Reactome
R-HSA-377644
(
R-HSA-354192
)
R-HSA-380780
(
R-HSA-186763
)
R-HSA-418850
(
R-HSA-418885
)
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418858
(
R-HSA-418885
)
R-HSA-418858
Reaction Name: RhoGTPase GEF's recruited to DCC
See in Reactome
R-HSA-418859
(
R-HSA-418886
)
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-418868
(
R-HSA-418885
)
R-HSA-418868
Reaction Name: Recruitment of Src and Fyn to DCC:FADK1
See in Reactome
R-HSA-418874
(
R-HSA-418885
)
R-HSA-418874
Reaction Name: Recruitment and activation of N-WASP by Cdc42
See in Reactome
R-HSA-429415
(
R-HSA-354192
)
R-HSA-429415
Reaction Name: SYK binds to integrin alphaIIb beta3
See in Reactome
R-HSA-429441
(
R-HSA-354192
)
R-HSA-432096
(
R-HSA-354192
)
R-HSA-432096
Reaction Name: Activated integrin alphaIIb beta3 binds SHC1
See in Reactome
R-HSA-443905
(
R-HSA-354192
)
R-HSA-443905
Reaction Name: SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow
See in Reactome
R-HSA-443910
(
R-HSA-354192
)
R-HSA-443910
Reaction Name: SHC1 dissociates from integrin alphaIIb beta3
See in Reactome
R-HSA-5672969
(
R-HSA-5673000
)
R-HSA-5672972
(
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-8874080
(
R-HSA-8874081
)
R-HSA-8874082
(
R-HSA-8874081
)
R-HSA-8874083
(
R-HSA-8874081
)
R-HSA-8937682
(
R-HSA-8934593
)
R-HSA-8937728
(
R-HSA-8934593
)
R-HSA-8937792
(
R-HSA-8941858
)
R-HSA-8937807
(
R-HSA-8941858
)
R-HSA-8937814
(
R-HSA-8941858
)
R-HSA-8937814
Reaction Name: RUNX3 translocates to the nucleus
See in Reactome
R-HSA-8937820
(
R-HSA-8940973
)
R-HSA-8937844
(
R-HSA-8940973
)
R-HSA-8964242
(
R-HSA-418594
)
R-HSA-8964242
Reaction Name: G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC
See in Reactome
R-HSA-8964252
(
R-HSA-418555
)
R-HSA-8964252
Reaction Name: G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC
See in Reactome
R-HSA-8964278
(
R-HSA-418555
)
R-HSA-8964278
Reaction Name: G protein alpha (s):GTP binds SRC
See in Reactome
R-HSA-8964287
(
R-HSA-418555
)
R-HSA-8964287
Reaction Name: G alpha (s):GTP:SRC dissociates
See in Reactome
R-HSA-8964311
(
R-HSA-418594
)
R-HSA-8964329
(
R-HSA-418594
)
R-HSA-8964329
Reaction Name: G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC
See in Reactome
R-HSA-9011241
(
R-HSA-428542
)
R-HSA-9011241
Reaction Name: SRC phosphorylates ROBO3.1 in response to NTN1
See in Reactome
R-HSA-9021596
(
R-HSA-9009391
)
R-HSA-9021596
Reaction Name: Membrane estrogen receptors bind SRC
See in Reactome
R-HSA-9021609
(
R-HSA-9009391
)
R-HSA-9021609
Reaction Name: ESR-associated SRC autophosphorylates
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9037040
(
R-HSA-9032500
)
R-HSA-9603419
(
R-HSA-9603381
)
R-HSA-9603420
(
R-HSA-9603381
)
R-HSA-9603420
Reaction Name: Activated NTRK3 promotes SRC autophosphorylation
See in Reactome
R-HSA-9603437
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9612085
(
R-HSA-9620244
)
R-HSA-9612085
Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs
See in Reactome
R-HSA-9612219
(
R-HSA-1253288
)
R-HSA-9624014
(
R-HSA-418555
)
R-HSA-9624014
Reaction Name: SHC1 is phosphorylated downstream of estrogen stimulation of GPER1
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9657599
(
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9726848
(
R-HSA-9013420
)
|
MONDO:0005335 |
RHOA |
P61586 |
3.6.5.2
|
R-HSA-198203
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-6798695
R-HSA-8980692
R-HSA-5625900
R-HSA-5625740
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-2173791
R-HSA-2173791
Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
See in Reactome
R-HSA-209563
R-HSA-4420097
R-HSA-193634
R-HSA-193634
Reactome Name: Axonal growth inhibition (RHOA activation)
See in Reactome
R-HSA-5663220
R-HSA-416482
R-HSA-416482
Reactome Name: G alpha (12/13) signalling events
See in Reactome
R-HSA-5666185
R-HSA-5666185
Reactome Name: RHO GTPases Activate Rhotekin and Rhophilins
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-5627117
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-9013106
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-8985586
R-HSA-8985586
Reactome Name: SLIT2:ROBO1 increases RHOA activity
See in Reactome
R-HSA-6785631
|
R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8848021
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-73887
R-HSA-388396
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-168249
R-HSA-392499
R-HSA-373755
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-2682334
R-HSA-187037
R-HSA-195258
R-HSA-195721
R-HSA-372790
R-HSA-193697
R-HSA-5688426
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1227986
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
|
Immune System
Developmental Biology
Metabolism of proteins
Hemostasis
Signal Transduction
|
R-HSA-114544
(
R-HSA-416482
)
R-HSA-193646
(
R-HSA-209563
)
R-HSA-193646
Reaction Name: NGF binding to p75NTR inactivates RHOA
See in Reactome
R-HSA-193668
(
R-HSA-209563
)
R-HSA-193696
(
R-HSA-193634
)
R-HSA-193696
Reaction Name: The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
See in Reactome
R-HSA-194518
(
R-HSA-193634
)
R-HSA-194518
Reaction Name: RhoA is activated by nucleotide exchange and inhibits axonal growth
See in Reactome
R-HSA-202692
(
R-HSA-198203;
R-HSA-392451
)
R-HSA-202692
Reaction Name: PIP3 binds to RhoA and activates it
See in Reactome
R-HSA-2134506
(
R-HSA-2173791
)
R-HSA-2134506
Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A
See in Reactome
R-HSA-2134519
(
R-HSA-2173791
)
R-HSA-2134519
Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation
See in Reactome
R-HSA-2134532
(
R-HSA-2173791
)
R-HSA-2134532
Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A
See in Reactome
R-HSA-2160931
(
R-HSA-2173791
)
R-HSA-2160931
Reaction Name: Disassembly of tight junctions
See in Reactome
R-HSA-2160932
(
R-HSA-2173791
)
R-HSA-2160932
Reaction Name: SMURF1 binds phosphorylated PARD6A
See in Reactome
R-HSA-2160935
(
R-HSA-2173791
)
R-HSA-3858495
(
R-HSA-4086400;
R-HSA-5663220
)
R-HSA-3928576
(
R-HSA-2682334;
R-HSA-3928662
)
R-HSA-3928576
Reaction Name: RHOA:GTP binds ROCK, activating it
See in Reactome
R-HSA-3928577
(
R-HSA-2682334;
R-HSA-3928662
)
R-HSA-3928592
(
R-HSA-2682334;
R-HSA-3928662
)
R-HSA-3928592
Reaction Name: p190RhoGEF exchanges GTP for GDP on RHOA, activating it
See in Reactome
R-HSA-3928616
(
R-HSA-2682334;
R-HSA-3928663
)
R-HSA-3928616
Reaction Name: Activated ROCK phosphorylates MRLCs
See in Reactome
R-HSA-3928647
(
R-HSA-4420097
)
R-HSA-3928647
Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2
See in Reactome
R-HSA-3928651
(
R-HSA-2682334;
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-416559
(
R-HSA-416550
)
R-HSA-416559
Reaction Name: Inactivation of Rho-GTP by p190RhoGAP
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-419049
(
R-HSA-416482;
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419083
(
R-HSA-5627117
)
R-HSA-419083
Reaction Name: Myosin phosphatase inactivation by ROCK
See in Reactome
R-HSA-419087
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419087
Reaction Name: LIM kinase phosphorylation by ROCK
See in Reactome
R-HSA-419166
(
R-HSA-416482
)
R-HSA-419197
(
R-HSA-416572;
R-HSA-5627117
)
R-HSA-419197
Reaction Name: Myosin regulatory light chain phosphorylation by ROCK
See in Reactome
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-5218826
(
R-HSA-4420097
)
R-HSA-5218826
Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
See in Reactome
R-HSA-5228992
(
R-HSA-4420097
)
R-HSA-5623622
(
R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
(
R-HSA-5625740
)
R-HSA-5625901
(
R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5665982
(
R-HSA-5663220
)
R-HSA-5665982
Reaction Name: RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
See in Reactome
R-HSA-5665989
(
R-HSA-5663220
)
R-HSA-5666178
(
R-HSA-5666185
)
R-HSA-5666197
(
R-HSA-5666185
)
R-HSA-5666216
(
R-HSA-5666185
)
R-HSA-5667008
(
R-HSA-5666185
)
R-HSA-5667052
(
R-HSA-5666185
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-6785648
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8849082
(
R-HSA-8849471
)
R-HSA-8849082
Reaction Name: ARHGAP35 stimulates RHOA GTPase activity
See in Reactome
R-HSA-8849085
(
R-HSA-8849471
)
R-HSA-8980691
(
R-HSA-8980692
)
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981637
(
R-HSA-8980692
)
R-HSA-8981637
Reaction Name: RHOA GAPs stimulate RHOA GTPase activity
See in Reactome
R-HSA-8985594
(
R-HSA-8985586
)
R-HSA-9012761
(
R-HSA-193634
)
R-HSA-9012761
Reaction Name: The p75NTR:NgR:MDGI binds RHOA-GDI
See in Reactome
R-HSA-9012835
(
R-HSA-8980692
)
R-HSA-9013004
(
R-HSA-8980692
)
R-HSA-9013004
Reaction Name: RHOA binds effectors at the ER membrane
See in Reactome
R-HSA-9013006
(
R-HSA-8980692
)
R-HSA-9013006
Reaction Name: RHOA:GTP translocates to the ER membrane
See in Reactome
R-HSA-9013009
(
R-HSA-8980692
)
R-HSA-9013009
Reaction Name: RHOA binds effectors at the plasma membrane
See in Reactome
R-HSA-9013110
(
R-HSA-9013106
)
R-HSA-9013110
Reaction Name: RHOC binds effectors at the plasma membrane
See in Reactome
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
SRC |
P12931 |
2.7.10.2
|
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-171007
R-HSA-428542
R-HSA-428542
Reactome Name: Regulation of commissural axon pathfinding by SLIT and ROBO
See in Reactome
R-HSA-418594
R-HSA-8940973
R-HSA-8940973
Reactome Name: RUNX2 regulates osteoblast differentiation
See in Reactome
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-437239
R-HSA-418592
R-HSA-418592
Reactome Name: ADP signalling through P2Y purinoceptor 1
See in Reactome
R-HSA-430116
R-HSA-430116
Reactome Name: GP1b-IX-V activation signalling
See in Reactome
R-HSA-5663220
R-HSA-186763
R-HSA-180292
R-HSA-8941858
R-HSA-8941858
Reactome Name: Regulation of RUNX3 expression and activity
See in Reactome
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-418555
R-HSA-5673000
R-HSA-9032500
R-HSA-9032500
Reactome Name: Activated NTRK2 signals through FYN
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-8934903
R-HSA-8853659
R-HSA-372708
R-HSA-372708
Reactome Name: p130Cas linkage to MAPK signaling for integrins
See in Reactome
R-HSA-389356
R-HSA-69231
R-HSA-69231
Reactome Name: Cyclin D associated events in G1
See in Reactome
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-4420097
R-HSA-1433559
R-HSA-2029481
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-1433557
R-HSA-9620244
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-5607764
R-HSA-5674135
R-HSA-8874081
R-HSA-1253288
R-HSA-1253288
Reactome Name: Downregulation of ERBB4 signaling
See in Reactome
R-HSA-2682334
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-177929
R-HSA-1251985
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-354194
R-HSA-354194
Reactome Name: GRB2:SOS provides linkage to MAPK signaling for Integrins
See in Reactome
R-HSA-3928664
R-HSA-456926
R-HSA-456926
Reactome Name: Thrombin signalling through proteinase activated receptors (PARs)
See in Reactome
R-HSA-354192
R-HSA-201556
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-191650
R-HSA-191650
Reactome Name: Regulation of gap junction activity
See in Reactome
R-HSA-9013420
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-1227986
R-HSA-5218921
R-HSA-5218921
Reactome Name: VEGFR2 mediated cell proliferation
See in Reactome
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-376176
R-HSA-9012999
R-HSA-8941326
R-HSA-8941326
Reactome Name: RUNX2 regulates bone development
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-195258
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-1640170
R-HSA-373760
R-HSA-5684996
R-HSA-1280218
R-HSA-1266738
R-HSA-5673001
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-9612973
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-69236
R-HSA-69278
R-HSA-5205647
R-HSA-388396
R-HSA-112316
R-HSA-162582
R-HSA-8875878
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5654743
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-9675108
R-HSA-168249
R-HSA-9663891
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-392518
R-HSA-8939211
R-HSA-157858
R-HSA-157858
Reactome Name: Gap junction trafficking and regulation
See in Reactome
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-1236394
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-187037
R-HSA-5653656
R-HSA-1632852
R-HSA-6806834
R-HSA-187687
R-HSA-372790
R-HSA-5654738
R-HSA-73857
R-HSA-5654736
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-9034015
R-HSA-186797
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-5654741
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-167044
R-HSA-373752
|
Immune System
Cell-Cell communication
Cell Cycle
Developmental Biology
Autophagy
Gene expression (Transcription)
Neuronal System
Signal Transduction
Vesicle-mediated transport
Hemostasis
|
R-HSA-1252013
(
R-HSA-1251985
)
R-HSA-1252013
Reaction Name: Translocation of ERBB4s80 to the nucleus
See in Reactome
R-HSA-177923
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-186819
(
R-HSA-186763
)
R-HSA-186819
Reaction Name: SH2 domain of Src binds to the active receptor
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-354066
(
R-HSA-354192
)
R-HSA-354066
Reaction Name: Translocation of PTK2 to Focal complexes
See in Reactome
R-HSA-354073
(
R-HSA-354192
)
R-HSA-354073
Reaction Name: Autophosphorylation of PTK2 at Y397
See in Reactome
R-HSA-354077
(
R-HSA-354192
)
R-HSA-354077
Reaction Name: Integrin alphaIIb beta3 activation
See in Reactome
R-HSA-354087
(
R-HSA-354192;
R-HSA-354194
)
R-HSA-354124
(
R-HSA-354192
)
R-HSA-354124
Reaction Name: Phosphorylation of pPTK2 by SRC
See in Reactome
R-HSA-354149
(
R-HSA-354192
)
R-HSA-354149
Reaction Name: Interaction of integrin alphaIIb beta3 with Fibrinogen
See in Reactome
R-HSA-354165
(
R-HSA-354192;
R-HSA-354194
)
R-HSA-354165
Reaction Name: Interaction of SOS with GRB2 bound to FADK1
See in Reactome
R-HSA-372693
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372693
Reaction Name: Phosphorylation of BCAR1 by SRC-PTK2 complex
See in Reactome
R-HSA-372697
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372705
(
R-HSA-354192;
R-HSA-372708
)
R-HSA-372705
Reaction Name: Recruitment of BCAR1 to PTK2 complex
See in Reactome
R-HSA-373716
(
R-HSA-418885
)
R-HSA-374701
(
R-HSA-418885
)
R-HSA-377640
(
R-HSA-354192
)
R-HSA-377641
(
R-HSA-354192
)
R-HSA-377641
Reaction Name: Clustering of Integrin alphaIIb beta3 complexes
See in Reactome
R-HSA-377643
(
R-HSA-354192
)
R-HSA-377643
Reaction Name: Dephosphorylation of inactive SRC by PTPB1
See in Reactome
R-HSA-377644
(
R-HSA-354192
)
R-HSA-380780
(
R-HSA-186763
)
R-HSA-418850
(
R-HSA-418885
)
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418858
(
R-HSA-418885
)
R-HSA-418858
Reaction Name: RhoGTPase GEF's recruited to DCC
See in Reactome
R-HSA-418859
(
R-HSA-418886
)
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-418868
(
R-HSA-418885
)
R-HSA-418868
Reaction Name: Recruitment of Src and Fyn to DCC:FADK1
See in Reactome
R-HSA-418874
(
R-HSA-418885
)
R-HSA-418874
Reaction Name: Recruitment and activation of N-WASP by Cdc42
See in Reactome
R-HSA-429415
(
R-HSA-354192
)
R-HSA-429415
Reaction Name: SYK binds to integrin alphaIIb beta3
See in Reactome
R-HSA-429441
(
R-HSA-354192
)
R-HSA-432096
(
R-HSA-354192
)
R-HSA-432096
Reaction Name: Activated integrin alphaIIb beta3 binds SHC1
See in Reactome
R-HSA-443905
(
R-HSA-354192
)
R-HSA-443905
Reaction Name: SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow
See in Reactome
R-HSA-443910
(
R-HSA-354192
)
R-HSA-443910
Reaction Name: SHC1 dissociates from integrin alphaIIb beta3
See in Reactome
R-HSA-5672969
(
R-HSA-5673000
)
R-HSA-5672972
(
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-8874080
(
R-HSA-8874081
)
R-HSA-8874082
(
R-HSA-8874081
)
R-HSA-8874083
(
R-HSA-8874081
)
R-HSA-8937682
(
R-HSA-8934593
)
R-HSA-8937728
(
R-HSA-8934593
)
R-HSA-8937792
(
R-HSA-8941858
)
R-HSA-8937807
(
R-HSA-8941858
)
R-HSA-8937814
(
R-HSA-8941858
)
R-HSA-8937814
Reaction Name: RUNX3 translocates to the nucleus
See in Reactome
R-HSA-8937820
(
R-HSA-8940973
)
R-HSA-8937844
(
R-HSA-8940973
)
R-HSA-8964242
(
R-HSA-418594
)
R-HSA-8964242
Reaction Name: G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC
See in Reactome
R-HSA-8964252
(
R-HSA-418555
)
R-HSA-8964252
Reaction Name: G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC
See in Reactome
R-HSA-8964278
(
R-HSA-418555
)
R-HSA-8964278
Reaction Name: G protein alpha (s):GTP binds SRC
See in Reactome
R-HSA-8964287
(
R-HSA-418555
)
R-HSA-8964287
Reaction Name: G alpha (s):GTP:SRC dissociates
See in Reactome
R-HSA-8964311
(
R-HSA-418594
)
R-HSA-8964329
(
R-HSA-418594
)
R-HSA-8964329
Reaction Name: G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC
See in Reactome
R-HSA-9011241
(
R-HSA-428542
)
R-HSA-9011241
Reaction Name: SRC phosphorylates ROBO3.1 in response to NTN1
See in Reactome
R-HSA-9021596
(
R-HSA-9009391
)
R-HSA-9021596
Reaction Name: Membrane estrogen receptors bind SRC
See in Reactome
R-HSA-9021609
(
R-HSA-9009391
)
R-HSA-9021609
Reaction Name: ESR-associated SRC autophosphorylates
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9037040
(
R-HSA-9032500
)
R-HSA-9603419
(
R-HSA-9603381
)
R-HSA-9603420
(
R-HSA-9603381
)
R-HSA-9603420
Reaction Name: Activated NTRK3 promotes SRC autophosphorylation
See in Reactome
R-HSA-9603437
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9612085
(
R-HSA-9620244
)
R-HSA-9612085
Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs
See in Reactome
R-HSA-9612219
(
R-HSA-1253288
)
R-HSA-9624014
(
R-HSA-418555
)
R-HSA-9624014
Reaction Name: SHC1 is phosphorylated downstream of estrogen stimulation of GPER1
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9657599
(
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
R-HSA-9726848
(
R-HSA-9013420
)
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
EPHA3 |
P29320 |
2.7.10.1
|
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-2682334
R-HSA-3928663
R-HSA-3928663
Reactome Name: EPHA-mediated growth cone collapse
See in Reactome
|
R-HSA-422475
R-HSA-9675108
R-HSA-1266738
|
Developmental Biology
|
R-HSA-3928578
(
R-HSA-2682334
)
R-HSA-3928578
Reaction Name: EPH receptors autophosphorylate
See in Reactome
R-HSA-3928584
(
R-HSA-2682334
)
R-HSA-3928591
(
R-HSA-2682334
)
R-HSA-3928597
(
R-HSA-2682334
)
R-HSA-3928602
(
R-HSA-2682334;
R-HSA-3928663
)
R-HSA-3928604
(
R-HSA-2682334;
R-HSA-3928665
)
R-HSA-3928607
(
R-HSA-2682334;
R-HSA-3928665
)
R-HSA-3928628
(
R-HSA-2682334;
R-HSA-3928665
)
R-HSA-3928628
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928642
(
R-HSA-2682334;
R-HSA-3928665
)
R-HSA-3928642
Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928646
(
R-HSA-2682334
)
R-HSA-3928648
(
R-HSA-2682334;
R-HSA-3928663
)
R-HSA-3928651
(
R-HSA-2682334;
R-HSA-3928663
)
R-HSA-3928651
Reaction Name: NGEF exchanges GTP for GDP on RHOA
See in Reactome
R-HSA-3928660
(
R-HSA-2682334;
R-HSA-3928665
)
R-HSA-4093327
(
R-HSA-2682334;
R-HSA-3928665
)
|
MONDO:0007288 |
MONDO:0007288
Disease Name: