DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-392154)

Number of enzymes:	3
Number of disease:	4
Number of reactomes:	10
Number of reactions:	27

Search results (Reactome ID: R-HSA-392154)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005387	NOS3	P29474	1.14.13.39	R-HSA-1222556 R-HSA-1222556 Reactome Name: ROS and RNS production in phagocytes See in Reactome R-HSA-203754 R-HSA-203754 Reactome Name: NOSIP mediated eNOS trafficking See in Reactome R-HSA-392154 R-HSA-392154 Reactome Name: Nitric oxide stimulates guanylate cyclase See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-203641 R-HSA-203641 Reactome Name: NOSTRIN mediated eNOS trafficking See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism Hemostasis Signal Transduction	R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-202110 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202110 Reaction Name: eNOS:Caveolin-1 complex binds to CaM See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202129 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202129 Reaction Name: HSP90 binds eNOS:Caveolin-1:CaM complex See in Reactome R-HSA-202132 ( R-HSA-203615 ) R-HSA-202132 Reaction Name: depalmitoylated eNOS translocates from plasma membrane See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-202144 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202144 Reaction Name: Caveolin-1 dissociates from eNOS:CaM:HSP90 complex See in Reactome R-HSA-203553 ( R-HSA-203754 ) R-HSA-203553 Reaction Name: eNOS binds NOSIP See in Reactome R-HSA-203565 ( R-HSA-203641 ) R-HSA-203565 Reaction Name: eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP See in Reactome R-HSA-203567 ( R-HSA-203615 ) R-HSA-203567 Reaction Name: palmitoylation of eNOS See in Reactome R-HSA-203611 ( R-HSA-203615 ) R-HSA-203611 Reaction Name: N-myristoylation of eNOS See in Reactome R-HSA-203613 ( R-HSA-203615 ) R-HSA-203613 Reaction Name: depalmitoylation of eNOS See in Reactome R-HSA-203625 ( R-HSA-203641 ) R-HSA-203625 Reaction Name: NOSTRIN mediated translocation of eNOS from plasma membrane See in Reactome R-HSA-203662 ( R-HSA-203641 ) R-HSA-203662 Reaction Name: eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 See in Reactome R-HSA-203680 ( R-HSA-203754 ) R-HSA-203680 Reaction Name: eNOS:NOSIP translocation from caveolae to intracellular compartments See in Reactome R-HSA-203700 ( R-HSA-203615 ) R-HSA-203700 Reaction Name: eNOS translocation from Golgi to Caveolae See in Reactome R-HSA-203712 ( R-HSA-203615 ) R-HSA-203712 Reaction Name: eNOS associates with Caveolin-1 See in Reactome R-HSA-203716 ( R-HSA-203641 ) R-HSA-203716 Reaction Name: eNOS:Caveolin-1 complex binds to Nostrin See in Reactome R-HSA-418436 ( R-HSA-1222556; R-HSA-392154 ) R-HSA-418436 Reaction Name: Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) See in Reactome
MONDO:0009649	GUCY1A1	Q02108	4.6.1.2	R-HSA-445355 R-HSA-445355 Reactome Name: Smooth Muscle Contraction See in Reactome R-HSA-392154 R-HSA-392154 Reactome Name: Nitric oxide stimulates guanylate cyclase See in Reactome	R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome	Muscle contraction Hemostasis	R-HSA-392143 ( R-HSA-392154; R-HSA-445355 ) R-HSA-392143 Reaction Name: NO binds to Guanylate Cyclase See in Reactome R-HSA-392152 ( R-HSA-392154; R-HSA-445355 ) R-HSA-392152 Reaction Name: Soluble guanylate cyclase converts GTP to cGMP See in Reactome
MONDO:0014331	GUCY1A1	Q02108	4.6.1.2	R-HSA-445355 R-HSA-445355 Reactome Name: Smooth Muscle Contraction See in Reactome R-HSA-392154 R-HSA-392154 Reactome Name: Nitric oxide stimulates guanylate cyclase See in Reactome	R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome	Muscle contraction Hemostasis	R-HSA-392143 ( R-HSA-392154; R-HSA-445355 ) R-HSA-392143 Reaction Name: NO binds to Guanylate Cyclase See in Reactome R-HSA-392152 ( R-HSA-392154; R-HSA-445355 ) R-HSA-392152 Reaction Name: Soluble guanylate cyclase converts GTP to cGMP See in Reactome
MONDO:0019635	NOS1	P29475	1.14.13.39	R-HSA-1222556 R-HSA-1222556 Reactome Name: ROS and RNS production in phagocytes See in Reactome R-HSA-5578775 R-HSA-5578775 Reactome Name: Ion homeostasis See in Reactome R-HSA-392154 R-HSA-392154 Reactome Name: Nitric oxide stimulates guanylate cyclase See in Reactome	R-HSA-5576891 R-HSA-5576891 Reactome Name: Cardiac conduction See in Reactome R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Muscle contraction Immune System Hemostasis	R-HSA-418436 ( R-HSA-1222556; R-HSA-392154 ) R-HSA-418436 Reaction Name: Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) See in Reactome R-HSA-5617178 ( R-HSA-5578775 ) R-HSA-5617178 Reaction Name: ATP2B4 binds to NOS1, inhibiting it See in Reactome R-HSA-5617179 ( R-HSA-5578775 ) R-HSA-5617179 Reaction Name: PRKACA phosphorylates TNNI3 See in Reactome R-HSA-5617182 ( R-HSA-5578775 ) R-HSA-5617182 Reaction Name: PRKACA phosphorylates PLN See in Reactome