DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-389948)

Number of enzymes:	2
Number of disease:	11
Number of reactomes:	59
Number of reactions:	145

Search results (Reactome ID: R-HSA-389948)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0002049	PTPN11	Q06124	3.1.3.48	R-HSA-389948 R-HSA-389948 Reactome Name: PD-1 signaling See in Reactome R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-432142 R-HSA-432142 Reactome Name: Platelet sensitization by LDL See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9645135 R-HSA-9645135 Reactome Name: STAT5 Activation See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Developmental Biology Gene expression (Transcription) Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1549564 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1549564 Reaction Name: PPTN11 dephosphorylates SPRY2 See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-177923 ( R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177926 ( R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177935 ( R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177944 ( R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-186778 ( R-HSA-186763 ) R-HSA-186778 Reaction Name: SHP2 binds to the active receptor See in Reactome R-HSA-204873 ( R-HSA-210993 ) R-HSA-204873 Reaction Name: Interaction of Tie2 and Shp2 See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-210294 ( R-HSA-210990; R-HSA-432142 ) R-HSA-210294 Reaction Name: Interaction of PECAM-1 and SHP-2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-388829 ( R-HSA-388841; R-HSA-389513 ) R-HSA-388829 Reaction Name: SHP2 phosphatase binds CTLA-4 See in Reactome R-HSA-389758 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389758 Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases See in Reactome R-HSA-389759 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389759 Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1 See in Reactome R-HSA-389941 ( R-HSA-388841 ) R-HSA-389941 Reaction Name: SHP-1 and SHP-2 bind pBTLA See in Reactome R-HSA-391150 ( R-HSA-391160 ) R-HSA-391150 Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 See in Reactome R-HSA-418863 ( R-HSA-418886 ) R-HSA-418863 Reaction Name: Shp2 binds pUnc5C See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5654584 ( R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654587 ( R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654594 ( R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654607 ( R-HSA-5654700 ) R-HSA-5654607 Reaction Name: Activated FGFR2 phosphorylates PPTN11 See in Reactome R-HSA-5654608 ( R-HSA-5654700 ) R-HSA-5654608 Reaction Name: Activated FGFR2:p-FRS bind to PPTN11 See in Reactome R-HSA-5654620 ( R-HSA-5654695 ) R-HSA-5654620 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654631 ( R-HSA-5654706 ) R-HSA-5654631 Reaction Name: Activated FGFR3 phosphorylates PPTN11 See in Reactome R-HSA-5654633 ( R-HSA-5654706 ) R-HSA-5654633 Reaction Name: Activated FGFR3:p-FRS bind to PPTN11 See in Reactome R-HSA-5654641 ( R-HSA-5654710 ) R-HSA-5654641 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654655 ( R-HSA-5654712 ) R-HSA-5654655 Reaction Name: Activated FGFR4 phosphorylates PPTN11 See in Reactome R-HSA-5654658 ( R-HSA-5654712 ) R-HSA-5654658 Reaction Name: Activated FGFR4:p-FRS bind to PPTN11 See in Reactome R-HSA-5654667 ( R-HSA-5654720 ) R-HSA-5654667 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654677 ( R-HSA-5654727 ) R-HSA-5654677 Reaction Name: CBL ubiquitinates FRS2 and FGFR2 See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654729 ( R-HSA-5654727 ) R-HSA-5654729 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-5684169 ( R-HSA-114604 ) R-HSA-5684169 Reaction Name: G6B binds PTPN6,PTPN11 See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-877308 ( R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-8855508 ( R-HSA-8853659 ) R-HSA-8855508 Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8937744 ( R-HSA-8934593 ) R-HSA-8937744 Reaction Name: PTPN11 binds p-7Y-RUNX1 See in Reactome R-HSA-8937767 ( R-HSA-8934593 ) R-HSA-8937767 Reaction Name: PTPN11 dephosphorylates RUNX1 See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9008894 ( R-HSA-9008059 ) R-HSA-9008894 Reaction Name: PTPNs gene transcription and translation See in Reactome R-HSA-9031981 ( R-HSA-9028731 ) R-HSA-9031981 Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11 See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-914022 ( R-HSA-512988 ) R-HSA-914022 Reaction Name: SHP2 can recruit GRB2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9604969 ( R-HSA-9607240 ) R-HSA-9604969 Reaction Name: Active FLT3 binds PTPN11 See in Reactome R-HSA-9606784 ( R-HSA-9607240 ) R-HSA-9606784 Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 See in Reactome R-HSA-9645126 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645126 Reaction Name: Activators bind STAT5 See in Reactome R-HSA-9645134 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645134 Reaction Name: p-STAT5 dissociates from activator:STAT5 complex See in Reactome R-HSA-9645137 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645137 Reaction Name: Activator phosphorylates STAT5 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome
MONDO:0005062	PTPN11	Q06124	3.1.3.48	R-HSA-389948 R-HSA-389948 Reactome Name: PD-1 signaling See in Reactome R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-432142 R-HSA-432142 Reactome Name: Platelet sensitization by LDL See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9645135 R-HSA-9645135 Reactome Name: STAT5 Activation See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Developmental Biology Gene expression (Transcription) Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1549564 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1549564 Reaction Name: PPTN11 dephosphorylates SPRY2 See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-177923 ( R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177926 ( R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177935 ( R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177944 ( R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-186778 ( R-HSA-186763 ) R-HSA-186778 Reaction Name: SHP2 binds to the active receptor See in Reactome R-HSA-204873 ( R-HSA-210993 ) R-HSA-204873 Reaction Name: Interaction of Tie2 and Shp2 See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-210294 ( R-HSA-210990; R-HSA-432142 ) R-HSA-210294 Reaction Name: Interaction of PECAM-1 and SHP-2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-388829 ( R-HSA-388841; R-HSA-389513 ) R-HSA-388829 Reaction Name: SHP2 phosphatase binds CTLA-4 See in Reactome R-HSA-389758 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389758 Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases See in Reactome R-HSA-389759 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389759 Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1 See in Reactome R-HSA-389941 ( R-HSA-388841 ) R-HSA-389941 Reaction Name: SHP-1 and SHP-2 bind pBTLA See in Reactome R-HSA-391150 ( R-HSA-391160 ) R-HSA-391150 Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 See in Reactome R-HSA-418863 ( R-HSA-418886 ) R-HSA-418863 Reaction Name: Shp2 binds pUnc5C See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5654584 ( R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654587 ( R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654594 ( R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654607 ( R-HSA-5654700 ) R-HSA-5654607 Reaction Name: Activated FGFR2 phosphorylates PPTN11 See in Reactome R-HSA-5654608 ( R-HSA-5654700 ) R-HSA-5654608 Reaction Name: Activated FGFR2:p-FRS bind to PPTN11 See in Reactome R-HSA-5654620 ( R-HSA-5654695 ) R-HSA-5654620 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654631 ( R-HSA-5654706 ) R-HSA-5654631 Reaction Name: Activated FGFR3 phosphorylates PPTN11 See in Reactome R-HSA-5654633 ( R-HSA-5654706 ) R-HSA-5654633 Reaction Name: Activated FGFR3:p-FRS bind to PPTN11 See in Reactome R-HSA-5654641 ( R-HSA-5654710 ) R-HSA-5654641 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654655 ( R-HSA-5654712 ) R-HSA-5654655 Reaction Name: Activated FGFR4 phosphorylates PPTN11 See in Reactome R-HSA-5654658 ( R-HSA-5654712 ) R-HSA-5654658 Reaction Name: Activated FGFR4:p-FRS bind to PPTN11 See in Reactome R-HSA-5654667 ( R-HSA-5654720 ) R-HSA-5654667 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654677 ( R-HSA-5654727 ) R-HSA-5654677 Reaction Name: CBL ubiquitinates FRS2 and FGFR2 See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654729 ( R-HSA-5654727 ) R-HSA-5654729 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-5684169 ( R-HSA-114604 ) R-HSA-5684169 Reaction Name: G6B binds PTPN6,PTPN11 See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-877308 ( R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-8855508 ( R-HSA-8853659 ) R-HSA-8855508 Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8937744 ( R-HSA-8934593 ) R-HSA-8937744 Reaction Name: PTPN11 binds p-7Y-RUNX1 See in Reactome R-HSA-8937767 ( R-HSA-8934593 ) R-HSA-8937767 Reaction Name: PTPN11 dephosphorylates RUNX1 See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9008894 ( R-HSA-9008059 ) R-HSA-9008894 Reaction Name: PTPNs gene transcription and translation See in Reactome R-HSA-9031981 ( R-HSA-9028731 ) R-HSA-9031981 Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11 See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-914022 ( R-HSA-512988 ) R-HSA-914022 Reaction Name: SHP2 can recruit GRB2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9604969 ( R-HSA-9607240 ) R-HSA-9604969 Reaction Name: Active FLT3 binds PTPN11 See in Reactome R-HSA-9606784 ( R-HSA-9607240 ) R-HSA-9606784 Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 See in Reactome R-HSA-9645126 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645126 Reaction Name: Activators bind STAT5 See in Reactome R-HSA-9645134 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645134 Reaction Name: p-STAT5 dissociates from activator:STAT5 complex See in Reactome R-HSA-9645137 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645137 Reaction Name: Activator phosphorylates STAT5 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome
MONDO:0005392	PTPN11	Q06124	3.1.3.48	R-HSA-389948 R-HSA-389948 Reactome Name: PD-1 signaling See in Reactome R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-432142 R-HSA-432142 Reactome Name: Platelet sensitization by LDL See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9645135 R-HSA-9645135 Reactome Name: STAT5 Activation See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Developmental Biology Gene expression (Transcription) Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1549564 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1549564 Reaction Name: PPTN11 dephosphorylates SPRY2 See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-177923 ( R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177926 ( R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177935 ( R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177944 ( R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-186778 ( R-HSA-186763 ) R-HSA-186778 Reaction Name: SHP2 binds to the active receptor See in Reactome R-HSA-204873 ( R-HSA-210993 ) R-HSA-204873 Reaction Name: Interaction of Tie2 and Shp2 See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-210294 ( R-HSA-210990; R-HSA-432142 ) R-HSA-210294 Reaction Name: Interaction of PECAM-1 and SHP-2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-388829 ( R-HSA-388841; R-HSA-389513 ) R-HSA-388829 Reaction Name: SHP2 phosphatase binds CTLA-4 See in Reactome R-HSA-389758 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389758 Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases See in Reactome R-HSA-389759 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389759 Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1 See in Reactome R-HSA-389941 ( R-HSA-388841 ) R-HSA-389941 Reaction Name: SHP-1 and SHP-2 bind pBTLA See in Reactome R-HSA-391150 ( R-HSA-391160 ) R-HSA-391150 Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 See in Reactome R-HSA-418863 ( R-HSA-418886 ) R-HSA-418863 Reaction Name: Shp2 binds pUnc5C See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5654584 ( R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654587 ( R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654594 ( R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654607 ( R-HSA-5654700 ) R-HSA-5654607 Reaction Name: Activated FGFR2 phosphorylates PPTN11 See in Reactome R-HSA-5654608 ( R-HSA-5654700 ) R-HSA-5654608 Reaction Name: Activated FGFR2:p-FRS bind to PPTN11 See in Reactome R-HSA-5654620 ( R-HSA-5654695 ) R-HSA-5654620 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654631 ( R-HSA-5654706 ) R-HSA-5654631 Reaction Name: Activated FGFR3 phosphorylates PPTN11 See in Reactome R-HSA-5654633 ( R-HSA-5654706 ) R-HSA-5654633 Reaction Name: Activated FGFR3:p-FRS bind to PPTN11 See in Reactome R-HSA-5654641 ( R-HSA-5654710 ) R-HSA-5654641 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654655 ( R-HSA-5654712 ) R-HSA-5654655 Reaction Name: Activated FGFR4 phosphorylates PPTN11 See in Reactome R-HSA-5654658 ( R-HSA-5654712 ) R-HSA-5654658 Reaction Name: Activated FGFR4:p-FRS bind to PPTN11 See in Reactome R-HSA-5654667 ( R-HSA-5654720 ) R-HSA-5654667 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654677 ( R-HSA-5654727 ) R-HSA-5654677 Reaction Name: CBL ubiquitinates FRS2 and FGFR2 See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654729 ( R-HSA-5654727 ) R-HSA-5654729 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-5684169 ( R-HSA-114604 ) R-HSA-5684169 Reaction Name: G6B binds PTPN6,PTPN11 See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-877308 ( R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-8855508 ( R-HSA-8853659 ) R-HSA-8855508 Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8937744 ( R-HSA-8934593 ) R-HSA-8937744 Reaction Name: PTPN11 binds p-7Y-RUNX1 See in Reactome R-HSA-8937767 ( R-HSA-8934593 ) R-HSA-8937767 Reaction Name: PTPN11 dephosphorylates RUNX1 See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9008894 ( R-HSA-9008059 ) R-HSA-9008894 Reaction Name: PTPNs gene transcription and translation See in Reactome R-HSA-9031981 ( R-HSA-9028731 ) R-HSA-9031981 Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11 See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-914022 ( R-HSA-512988 ) R-HSA-914022 Reaction Name: SHP2 can recruit GRB2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9604969 ( R-HSA-9607240 ) R-HSA-9604969 Reaction Name: Active FLT3 binds PTPN11 See in Reactome R-HSA-9606784 ( R-HSA-9607240 ) R-HSA-9606784 Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 See in Reactome R-HSA-9645126 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645126 Reaction Name: Activators bind STAT5 See in Reactome R-HSA-9645134 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645134 Reaction Name: p-STAT5 dissociates from activator:STAT5 complex See in Reactome R-HSA-9645137 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645137 Reaction Name: Activator phosphorylates STAT5 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome
MONDO:0007979	PTPN11	Q06124	3.1.3.48	R-HSA-389948 R-HSA-389948 Reactome Name: PD-1 signaling See in Reactome R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-432142 R-HSA-432142 Reactome Name: Platelet sensitization by LDL See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9645135 R-HSA-9645135 Reactome Name: STAT5 Activation See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Developmental Biology Gene expression (Transcription) Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1549564 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1549564 Reaction Name: PPTN11 dephosphorylates SPRY2 See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-177923 ( R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177926 ( R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177935 ( R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177944 ( R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-186778 ( R-HSA-186763 ) R-HSA-186778 Reaction Name: SHP2 binds to the active receptor See in Reactome R-HSA-204873 ( R-HSA-210993 ) R-HSA-204873 Reaction Name: Interaction of Tie2 and Shp2 See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-210294 ( R-HSA-210990; R-HSA-432142 ) R-HSA-210294 Reaction Name: Interaction of PECAM-1 and SHP-2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-388829 ( R-HSA-388841; R-HSA-389513 ) R-HSA-388829 Reaction Name: SHP2 phosphatase binds CTLA-4 See in Reactome R-HSA-389758 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389758 Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases See in Reactome R-HSA-389759 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389759 Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1 See in Reactome R-HSA-389941 ( R-HSA-388841 ) R-HSA-389941 Reaction Name: SHP-1 and SHP-2 bind pBTLA See in Reactome R-HSA-391150 ( R-HSA-391160 ) R-HSA-391150 Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 See in Reactome R-HSA-418863 ( R-HSA-418886 ) R-HSA-418863 Reaction Name: Shp2 binds pUnc5C See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5654584 ( R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654587 ( R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654594 ( R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654607 ( R-HSA-5654700 ) R-HSA-5654607 Reaction Name: Activated FGFR2 phosphorylates PPTN11 See in Reactome R-HSA-5654608 ( R-HSA-5654700 ) R-HSA-5654608 Reaction Name: Activated FGFR2:p-FRS bind to PPTN11 See in Reactome R-HSA-5654620 ( R-HSA-5654695 ) R-HSA-5654620 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654631 ( R-HSA-5654706 ) R-HSA-5654631 Reaction Name: Activated FGFR3 phosphorylates PPTN11 See in Reactome R-HSA-5654633 ( R-HSA-5654706 ) R-HSA-5654633 Reaction Name: Activated FGFR3:p-FRS bind to PPTN11 See in Reactome R-HSA-5654641 ( R-HSA-5654710 ) R-HSA-5654641 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654655 ( R-HSA-5654712 ) R-HSA-5654655 Reaction Name: Activated FGFR4 phosphorylates PPTN11 See in Reactome R-HSA-5654658 ( R-HSA-5654712 ) R-HSA-5654658 Reaction Name: Activated FGFR4:p-FRS bind to PPTN11 See in Reactome R-HSA-5654667 ( R-HSA-5654720 ) R-HSA-5654667 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654677 ( R-HSA-5654727 ) R-HSA-5654677 Reaction Name: CBL ubiquitinates FRS2 and FGFR2 See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654729 ( R-HSA-5654727 ) R-HSA-5654729 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-5684169 ( R-HSA-114604 ) R-HSA-5684169 Reaction Name: G6B binds PTPN6,PTPN11 See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-877308 ( R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-8855508 ( R-HSA-8853659 ) R-HSA-8855508 Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8937744 ( R-HSA-8934593 ) R-HSA-8937744 Reaction Name: PTPN11 binds p-7Y-RUNX1 See in Reactome R-HSA-8937767 ( R-HSA-8934593 ) R-HSA-8937767 Reaction Name: PTPN11 dephosphorylates RUNX1 See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9008894 ( R-HSA-9008059 ) R-HSA-9008894 Reaction Name: PTPNs gene transcription and translation See in Reactome R-HSA-9031981 ( R-HSA-9028731 ) R-HSA-9031981 Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11 See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-914022 ( R-HSA-512988 ) R-HSA-914022 Reaction Name: SHP2 can recruit GRB2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9604969 ( R-HSA-9607240 ) R-HSA-9604969 Reaction Name: Active FLT3 binds PTPN11 See in Reactome R-HSA-9606784 ( R-HSA-9607240 ) R-HSA-9606784 Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 See in Reactome R-HSA-9645126 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645126 Reaction Name: Activators bind STAT5 See in Reactome R-HSA-9645134 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645134 Reaction Name: p-STAT5 dissociates from activator:STAT5 complex See in Reactome R-HSA-9645137 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645137 Reaction Name: Activator phosphorylates STAT5 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome
MONDO:0008104	PTPN11	Q06124	3.1.3.48	R-HSA-389948 R-HSA-389948 Reactome Name: PD-1 signaling See in Reactome R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-432142 R-HSA-432142 Reactome Name: Platelet sensitization by LDL See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9645135 R-HSA-9645135 Reactome Name: STAT5 Activation See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Developmental Biology Gene expression (Transcription) Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1549564 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1549564 Reaction Name: PPTN11 dephosphorylates SPRY2 See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-177923 ( R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177926 ( R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177935 ( R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177944 ( R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-186778 ( R-HSA-186763 ) R-HSA-186778 Reaction Name: SHP2 binds to the active receptor See in Reactome R-HSA-204873 ( R-HSA-210993 ) R-HSA-204873 Reaction Name: Interaction of Tie2 and Shp2 See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-210294 ( R-HSA-210990; R-HSA-432142 ) R-HSA-210294 Reaction Name: Interaction of PECAM-1 and SHP-2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-388829 ( R-HSA-388841; R-HSA-389513 ) R-HSA-388829 Reaction Name: SHP2 phosphatase binds CTLA-4 See in Reactome R-HSA-389758 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389758 Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases See in Reactome R-HSA-389759 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389759 Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1 See in Reactome R-HSA-389941 ( R-HSA-388841 ) R-HSA-389941 Reaction Name: SHP-1 and SHP-2 bind pBTLA See in Reactome R-HSA-391150 ( R-HSA-391160 ) R-HSA-391150 Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 See in Reactome R-HSA-418863 ( R-HSA-418886 ) R-HSA-418863 Reaction Name: Shp2 binds pUnc5C See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5654584 ( R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654587 ( R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654594 ( R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654607 ( R-HSA-5654700 ) R-HSA-5654607 Reaction Name: Activated FGFR2 phosphorylates PPTN11 See in Reactome R-HSA-5654608 ( R-HSA-5654700 ) R-HSA-5654608 Reaction Name: Activated FGFR2:p-FRS bind to PPTN11 See in Reactome R-HSA-5654620 ( R-HSA-5654695 ) R-HSA-5654620 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654631 ( R-HSA-5654706 ) R-HSA-5654631 Reaction Name: Activated FGFR3 phosphorylates PPTN11 See in Reactome R-HSA-5654633 ( R-HSA-5654706 ) R-HSA-5654633 Reaction Name: Activated FGFR3:p-FRS bind to PPTN11 See in Reactome R-HSA-5654641 ( R-HSA-5654710 ) R-HSA-5654641 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654655 ( R-HSA-5654712 ) R-HSA-5654655 Reaction Name: Activated FGFR4 phosphorylates PPTN11 See in Reactome R-HSA-5654658 ( R-HSA-5654712 ) R-HSA-5654658 Reaction Name: Activated FGFR4:p-FRS bind to PPTN11 See in Reactome R-HSA-5654667 ( R-HSA-5654720 ) R-HSA-5654667 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654677 ( R-HSA-5654727 ) R-HSA-5654677 Reaction Name: CBL ubiquitinates FRS2 and FGFR2 See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654729 ( R-HSA-5654727 ) R-HSA-5654729 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-5684169 ( R-HSA-114604 ) R-HSA-5684169 Reaction Name: G6B binds PTPN6,PTPN11 See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-877308 ( R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-8855508 ( R-HSA-8853659 ) R-HSA-8855508 Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8937744 ( R-HSA-8934593 ) R-HSA-8937744 Reaction Name: PTPN11 binds p-7Y-RUNX1 See in Reactome R-HSA-8937767 ( R-HSA-8934593 ) R-HSA-8937767 Reaction Name: PTPN11 dephosphorylates RUNX1 See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9008894 ( R-HSA-9008059 ) R-HSA-9008894 Reaction Name: PTPNs gene transcription and translation See in Reactome R-HSA-9031981 ( R-HSA-9028731 ) R-HSA-9031981 Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11 See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-914022 ( R-HSA-512988 ) R-HSA-914022 Reaction Name: SHP2 can recruit GRB2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9604969 ( R-HSA-9607240 ) R-HSA-9604969 Reaction Name: Active FLT3 binds PTPN11 See in Reactome R-HSA-9606784 ( R-HSA-9607240 ) R-HSA-9606784 Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 See in Reactome R-HSA-9645126 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645126 Reaction Name: Activators bind STAT5 See in Reactome R-HSA-9645134 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645134 Reaction Name: p-STAT5 dissociates from activator:STAT5 complex See in Reactome R-HSA-9645137 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645137 Reaction Name: Activator phosphorylates STAT5 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome
MONDO:0011908	PTPN11	Q06124	3.1.3.48	R-HSA-389948 R-HSA-389948 Reactome Name: PD-1 signaling See in Reactome R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-432142 R-HSA-432142 Reactome Name: Platelet sensitization by LDL See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9645135 R-HSA-9645135 Reactome Name: STAT5 Activation See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Developmental Biology Gene expression (Transcription) Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1549564 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1549564 Reaction Name: PPTN11 dephosphorylates SPRY2 See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-177923 ( R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177926 ( R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177935 ( R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177944 ( R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-186778 ( R-HSA-186763 ) R-HSA-186778 Reaction Name: SHP2 binds to the active receptor See in Reactome R-HSA-204873 ( R-HSA-210993 ) R-HSA-204873 Reaction Name: Interaction of Tie2 and Shp2 See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-210294 ( R-HSA-210990; R-HSA-432142 ) R-HSA-210294 Reaction Name: Interaction of PECAM-1 and SHP-2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-388829 ( R-HSA-388841; R-HSA-389513 ) R-HSA-388829 Reaction Name: SHP2 phosphatase binds CTLA-4 See in Reactome R-HSA-389758 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389758 Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases See in Reactome R-HSA-389759 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389759 Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1 See in Reactome R-HSA-389941 ( R-HSA-388841 ) R-HSA-389941 Reaction Name: SHP-1 and SHP-2 bind pBTLA See in Reactome R-HSA-391150 ( R-HSA-391160 ) R-HSA-391150 Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 See in Reactome R-HSA-418863 ( R-HSA-418886 ) R-HSA-418863 Reaction Name: Shp2 binds pUnc5C See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5654584 ( R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654587 ( R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654594 ( R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654607 ( R-HSA-5654700 ) R-HSA-5654607 Reaction Name: Activated FGFR2 phosphorylates PPTN11 See in Reactome R-HSA-5654608 ( R-HSA-5654700 ) R-HSA-5654608 Reaction Name: Activated FGFR2:p-FRS bind to PPTN11 See in Reactome R-HSA-5654620 ( R-HSA-5654695 ) R-HSA-5654620 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654631 ( R-HSA-5654706 ) R-HSA-5654631 Reaction Name: Activated FGFR3 phosphorylates PPTN11 See in Reactome R-HSA-5654633 ( R-HSA-5654706 ) R-HSA-5654633 Reaction Name: Activated FGFR3:p-FRS bind to PPTN11 See in Reactome R-HSA-5654641 ( R-HSA-5654710 ) R-HSA-5654641 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654655 ( R-HSA-5654712 ) R-HSA-5654655 Reaction Name: Activated FGFR4 phosphorylates PPTN11 See in Reactome R-HSA-5654658 ( R-HSA-5654712 ) R-HSA-5654658 Reaction Name: Activated FGFR4:p-FRS bind to PPTN11 See in Reactome R-HSA-5654667 ( R-HSA-5654720 ) R-HSA-5654667 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654677 ( R-HSA-5654727 ) R-HSA-5654677 Reaction Name: CBL ubiquitinates FRS2 and FGFR2 See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654729 ( R-HSA-5654727 ) R-HSA-5654729 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-5684169 ( R-HSA-114604 ) R-HSA-5684169 Reaction Name: G6B binds PTPN6,PTPN11 See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-877308 ( R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-8855508 ( R-HSA-8853659 ) R-HSA-8855508 Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8937744 ( R-HSA-8934593 ) R-HSA-8937744 Reaction Name: PTPN11 binds p-7Y-RUNX1 See in Reactome R-HSA-8937767 ( R-HSA-8934593 ) R-HSA-8937767 Reaction Name: PTPN11 dephosphorylates RUNX1 See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9008894 ( R-HSA-9008059 ) R-HSA-9008894 Reaction Name: PTPNs gene transcription and translation See in Reactome R-HSA-9031981 ( R-HSA-9028731 ) R-HSA-9031981 Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11 See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-914022 ( R-HSA-512988 ) R-HSA-914022 Reaction Name: SHP2 can recruit GRB2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9604969 ( R-HSA-9607240 ) R-HSA-9604969 Reaction Name: Active FLT3 binds PTPN11 See in Reactome R-HSA-9606784 ( R-HSA-9607240 ) R-HSA-9606784 Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 See in Reactome R-HSA-9645126 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645126 Reaction Name: Activators bind STAT5 See in Reactome R-HSA-9645134 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645134 Reaction Name: p-STAT5 dissociates from activator:STAT5 complex See in Reactome R-HSA-9645137 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645137 Reaction Name: Activator phosphorylates STAT5 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome
MONDO:0012371	PTPN11	Q06124	3.1.3.48	R-HSA-389948 R-HSA-389948 Reactome Name: PD-1 signaling See in Reactome R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-432142 R-HSA-432142 Reactome Name: Platelet sensitization by LDL See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9645135 R-HSA-9645135 Reactome Name: STAT5 Activation See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Developmental Biology Gene expression (Transcription) Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1549564 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1549564 Reaction Name: PPTN11 dephosphorylates SPRY2 See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-177923 ( R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177926 ( R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177935 ( R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177944 ( R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-186778 ( R-HSA-186763 ) R-HSA-186778 Reaction Name: SHP2 binds to the active receptor See in Reactome R-HSA-204873 ( R-HSA-210993 ) R-HSA-204873 Reaction Name: Interaction of Tie2 and Shp2 See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-210294 ( R-HSA-210990; R-HSA-432142 ) R-HSA-210294 Reaction Name: Interaction of PECAM-1 and SHP-2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-388829 ( R-HSA-388841; R-HSA-389513 ) R-HSA-388829 Reaction Name: SHP2 phosphatase binds CTLA-4 See in Reactome R-HSA-389758 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389758 Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases See in Reactome R-HSA-389759 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389759 Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1 See in Reactome R-HSA-389941 ( R-HSA-388841 ) R-HSA-389941 Reaction Name: SHP-1 and SHP-2 bind pBTLA See in Reactome R-HSA-391150 ( R-HSA-391160 ) R-HSA-391150 Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 See in Reactome R-HSA-418863 ( R-HSA-418886 ) R-HSA-418863 Reaction Name: Shp2 binds pUnc5C See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5654584 ( R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654587 ( R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654594 ( R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654607 ( R-HSA-5654700 ) R-HSA-5654607 Reaction Name: Activated FGFR2 phosphorylates PPTN11 See in Reactome R-HSA-5654608 ( R-HSA-5654700 ) R-HSA-5654608 Reaction Name: Activated FGFR2:p-FRS bind to PPTN11 See in Reactome R-HSA-5654620 ( R-HSA-5654695 ) R-HSA-5654620 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654631 ( R-HSA-5654706 ) R-HSA-5654631 Reaction Name: Activated FGFR3 phosphorylates PPTN11 See in Reactome R-HSA-5654633 ( R-HSA-5654706 ) R-HSA-5654633 Reaction Name: Activated FGFR3:p-FRS bind to PPTN11 See in Reactome R-HSA-5654641 ( R-HSA-5654710 ) R-HSA-5654641 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654655 ( R-HSA-5654712 ) R-HSA-5654655 Reaction Name: Activated FGFR4 phosphorylates PPTN11 See in Reactome R-HSA-5654658 ( R-HSA-5654712 ) R-HSA-5654658 Reaction Name: Activated FGFR4:p-FRS bind to PPTN11 See in Reactome R-HSA-5654667 ( R-HSA-5654720 ) R-HSA-5654667 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654677 ( R-HSA-5654727 ) R-HSA-5654677 Reaction Name: CBL ubiquitinates FRS2 and FGFR2 See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654729 ( R-HSA-5654727 ) R-HSA-5654729 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-5684169 ( R-HSA-114604 ) R-HSA-5684169 Reaction Name: G6B binds PTPN6,PTPN11 See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-877308 ( R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-8855508 ( R-HSA-8853659 ) R-HSA-8855508 Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8937744 ( R-HSA-8934593 ) R-HSA-8937744 Reaction Name: PTPN11 binds p-7Y-RUNX1 See in Reactome R-HSA-8937767 ( R-HSA-8934593 ) R-HSA-8937767 Reaction Name: PTPN11 dephosphorylates RUNX1 See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9008894 ( R-HSA-9008059 ) R-HSA-9008894 Reaction Name: PTPNs gene transcription and translation See in Reactome R-HSA-9031981 ( R-HSA-9028731 ) R-HSA-9031981 Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11 See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-914022 ( R-HSA-512988 ) R-HSA-914022 Reaction Name: SHP2 can recruit GRB2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9604969 ( R-HSA-9607240 ) R-HSA-9604969 Reaction Name: Active FLT3 binds PTPN11 See in Reactome R-HSA-9606784 ( R-HSA-9607240 ) R-HSA-9606784 Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 See in Reactome R-HSA-9645126 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645126 Reaction Name: Activators bind STAT5 See in Reactome R-HSA-9645134 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645134 Reaction Name: p-STAT5 dissociates from activator:STAT5 complex See in Reactome R-HSA-9645137 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645137 Reaction Name: Activator phosphorylates STAT5 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome
MONDO:0013308	PTPN11	Q06124	3.1.3.48	R-HSA-389948 R-HSA-389948 Reactome Name: PD-1 signaling See in Reactome R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-432142 R-HSA-432142 Reactome Name: Platelet sensitization by LDL See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9645135 R-HSA-9645135 Reactome Name: STAT5 Activation See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Developmental Biology Gene expression (Transcription) Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1549564 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1549564 Reaction Name: PPTN11 dephosphorylates SPRY2 See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-177923 ( R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177926 ( R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177935 ( R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177944 ( R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-186778 ( R-HSA-186763 ) R-HSA-186778 Reaction Name: SHP2 binds to the active receptor See in Reactome R-HSA-204873 ( R-HSA-210993 ) R-HSA-204873 Reaction Name: Interaction of Tie2 and Shp2 See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-210294 ( R-HSA-210990; R-HSA-432142 ) R-HSA-210294 Reaction Name: Interaction of PECAM-1 and SHP-2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-388829 ( R-HSA-388841; R-HSA-389513 ) R-HSA-388829 Reaction Name: SHP2 phosphatase binds CTLA-4 See in Reactome R-HSA-389758 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389758 Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases See in Reactome R-HSA-389759 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389759 Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1 See in Reactome R-HSA-389941 ( R-HSA-388841 ) R-HSA-389941 Reaction Name: SHP-1 and SHP-2 bind pBTLA See in Reactome R-HSA-391150 ( R-HSA-391160 ) R-HSA-391150 Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 See in Reactome R-HSA-418863 ( R-HSA-418886 ) R-HSA-418863 Reaction Name: Shp2 binds pUnc5C See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5654584 ( R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654587 ( R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654594 ( R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654607 ( R-HSA-5654700 ) R-HSA-5654607 Reaction Name: Activated FGFR2 phosphorylates PPTN11 See in Reactome R-HSA-5654608 ( R-HSA-5654700 ) R-HSA-5654608 Reaction Name: Activated FGFR2:p-FRS bind to PPTN11 See in Reactome R-HSA-5654620 ( R-HSA-5654695 ) R-HSA-5654620 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654631 ( R-HSA-5654706 ) R-HSA-5654631 Reaction Name: Activated FGFR3 phosphorylates PPTN11 See in Reactome R-HSA-5654633 ( R-HSA-5654706 ) R-HSA-5654633 Reaction Name: Activated FGFR3:p-FRS bind to PPTN11 See in Reactome R-HSA-5654641 ( R-HSA-5654710 ) R-HSA-5654641 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654655 ( R-HSA-5654712 ) R-HSA-5654655 Reaction Name: Activated FGFR4 phosphorylates PPTN11 See in Reactome R-HSA-5654658 ( R-HSA-5654712 ) R-HSA-5654658 Reaction Name: Activated FGFR4:p-FRS bind to PPTN11 See in Reactome R-HSA-5654667 ( R-HSA-5654720 ) R-HSA-5654667 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654677 ( R-HSA-5654727 ) R-HSA-5654677 Reaction Name: CBL ubiquitinates FRS2 and FGFR2 See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654729 ( R-HSA-5654727 ) R-HSA-5654729 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-5684169 ( R-HSA-114604 ) R-HSA-5684169 Reaction Name: G6B binds PTPN6,PTPN11 See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-877308 ( R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-8855508 ( R-HSA-8853659 ) R-HSA-8855508 Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8937744 ( R-HSA-8934593 ) R-HSA-8937744 Reaction Name: PTPN11 binds p-7Y-RUNX1 See in Reactome R-HSA-8937767 ( R-HSA-8934593 ) R-HSA-8937767 Reaction Name: PTPN11 dephosphorylates RUNX1 See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9008894 ( R-HSA-9008059 ) R-HSA-9008894 Reaction Name: PTPNs gene transcription and translation See in Reactome R-HSA-9031981 ( R-HSA-9028731 ) R-HSA-9031981 Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11 See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-914022 ( R-HSA-512988 ) R-HSA-914022 Reaction Name: SHP2 can recruit GRB2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9604969 ( R-HSA-9607240 ) R-HSA-9604969 Reaction Name: Active FLT3 binds PTPN11 See in Reactome R-HSA-9606784 ( R-HSA-9607240 ) R-HSA-9606784 Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 See in Reactome R-HSA-9645126 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645126 Reaction Name: Activators bind STAT5 See in Reactome R-HSA-9645134 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645134 Reaction Name: p-STAT5 dissociates from activator:STAT5 complex See in Reactome R-HSA-9645137 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645137 Reaction Name: Activator phosphorylates STAT5 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome
MONDO:0014334	LCK	P06239	2.7.10.2	R-HSA-202433 R-HSA-202433 Reactome Name: Generation of second messenger molecules See in Reactome R-HSA-389948 R-HSA-389948 Reactome Name: PD-1 signaling See in Reactome R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-202427 R-HSA-202427 Reactome Name: Phosphorylation of CD3 and TCR zeta chains See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9706374 R-HSA-9706374 Reactome Name: FLT3 signaling through SRC family kinases See in Reactome R-HSA-202430 R-HSA-202430 Reactome Name: Translocation of ZAP-70 to Immunological synapse See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-389359 R-HSA-389359 Reactome Name: CD28 dependent Vav1 pathway See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome	R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome	Hemostasis Immune System Signal Transduction	R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433506 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433506 Reaction Name: Phosphorylation of APS See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1433542 ( R-HSA-1433557 ) R-HSA-1433542 Reaction Name: Phosphorylation and activation of VAV1 See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-1472121 ( R-HSA-1433557 ) R-HSA-1472121 Reaction Name: Phosphorylation of p-KIT on Y900 by Src kinases See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-202165 ( R-HSA-202427 ) R-HSA-202165 Reaction Name: Phosphorylation of ITAM motifs in CD3 complexes See in Reactome R-HSA-202168 ( R-HSA-202430 ) R-HSA-202168 Reaction Name: Phosphorylation of ZAP-70 by Lck See in Reactome R-HSA-202174 ( R-HSA-202430 ) R-HSA-202174 Reaction Name: Activation of ZAP-70 See in Reactome R-HSA-202214 ( R-HSA-202427 ) R-HSA-202214 Reaction Name: Dephosphorylation of Lck-pY505 by CD45 See in Reactome R-HSA-202216 ( R-HSA-202433 ) R-HSA-202216 Reaction Name: Phosphorylation of SLP-76 See in Reactome R-HSA-202233 ( R-HSA-202427 ) R-HSA-202233 Reaction Name: Inactivation of Lck by Csk See in Reactome R-HSA-202245 ( R-HSA-202433 ) R-HSA-202245 Reaction Name: Phosphorylation of TBSMs in LAT See in Reactome R-HSA-202248 ( R-HSA-202433 ) R-HSA-202248 Reaction Name: Phosphorylation of PLC-gamma1 See in Reactome R-HSA-202291 ( R-HSA-202427 ) R-HSA-202291 Reaction Name: Activation of Lck See in Reactome R-HSA-202307 ( R-HSA-202424 ) R-HSA-202307 Reaction Name: Change of PKC theta conformation See in Reactome R-HSA-202344 ( R-HSA-202430 ) R-HSA-202344 Reaction Name: Recruitment of ZAP-70 to phosphorylated ITAMs See in Reactome R-HSA-205205 ( R-HSA-1433557 ) R-HSA-205205 Reaction Name: Interaction of Src family kinases with p-KIT See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-205244 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205244 Reaction Name: Recruitment of CBL to KIT See in Reactome R-HSA-205319 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205319 Reaction Name: Interaction of APS and p-KIT See in Reactome R-HSA-210289 ( R-HSA-2424491 ) R-HSA-210289 Reaction Name: Recruitment of SYK to p-DAP12 See in Reactome R-HSA-210291 ( R-HSA-210990 ) R-HSA-210291 Reaction Name: Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2395412 ( R-HSA-2424491 ) R-HSA-2395412 Reaction Name: Phosphorylation of SYK See in Reactome R-HSA-2395439 ( R-HSA-2424491 ) R-HSA-2395439 Reaction Name: Phosphorylation of DAP12 See in Reactome R-HSA-2395801 ( R-HSA-2424491 ) R-HSA-2395801 Reaction Name: Phosphorylation of LAT by p-SYK See in Reactome R-HSA-2396594 ( R-HSA-2424491 ) R-HSA-2396594 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2424484 ( R-HSA-2424491 ) R-HSA-2424484 Reaction Name: Phosphorylation of BTK by p-SYK See in Reactome R-HSA-2424486 ( R-HSA-2424491 ) R-HSA-2424486 Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK See in Reactome R-HSA-2424487 ( R-HSA-2424491 ) R-HSA-2424487 Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK See in Reactome R-HSA-388814 ( R-HSA-388841; R-HSA-389356; R-HSA-389359 ) R-HSA-388814 Reaction Name: Grb2 binds CD28 See in Reactome R-HSA-388829 ( R-HSA-388841; R-HSA-389513 ) R-HSA-388829 Reaction Name: SHP2 phosphatase binds CTLA-4 See in Reactome R-HSA-388831 ( R-HSA-388841; R-HSA-389356 ) R-HSA-388831 Reaction Name: Phosphorylation of CD28 See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389356; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-388833 ( R-HSA-388841; R-HSA-389513 ) R-HSA-388833 Reaction Name: Phosphorylation of CTLA-4 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389356; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-389348 ( R-HSA-388841; R-HSA-389356; R-HSA-389359 ) R-HSA-389348 Reaction Name: Activation of Rac1 by pVav1 See in Reactome R-HSA-389350 ( R-HSA-388841; R-HSA-389356; R-HSA-389359 ) R-HSA-389350 Reaction Name: Activation of Cdc42 by pVav1 See in Reactome R-HSA-389352 ( R-HSA-388841; R-HSA-389356; R-HSA-389359 ) R-HSA-389352 Reaction Name: Translocation of Vav1 to CD28 See in Reactome R-HSA-389354 ( R-HSA-388841; R-HSA-389356; R-HSA-389359 ) R-HSA-389354 Reaction Name: Activation of Vav1 See in Reactome R-HSA-389381 ( R-HSA-388841; R-HSA-389356 ) R-HSA-389381 Reaction Name: Gads binds CD28 See in Reactome R-HSA-389758 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389758 Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases See in Reactome R-HSA-389759 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389759 Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1 See in Reactome R-HSA-389762 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389762 Reaction Name: Phosphorylation of PD-1 See in Reactome R-HSA-434836 ( R-HSA-114604 ) R-HSA-434836 Reaction Name: Syk/Lck phosphorylate LAT See in Reactome R-HSA-452100 ( R-HSA-9020558 ) R-HSA-452100 Reaction Name: SHC1 bound to IL2 receptor is phosphorylated See in Reactome R-HSA-8852200 ( R-HSA-202427 ) R-HSA-8852200 Reaction Name: Inactivation of LCK by PTPN22 See in Reactome R-HSA-8855381 ( R-HSA-202430 ) R-HSA-8855381 Reaction Name: PTPN22 dephosphorylates ZAP70 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome R-HSA-9706312 ( R-HSA-9607240; R-HSA-9706374 ) R-HSA-9706312 Reaction Name: Active FLT3 binds to LCK See in Reactome
MONDO:0016225	PTPN11	Q06124	3.1.3.48	R-HSA-389948 R-HSA-389948 Reactome Name: PD-1 signaling See in Reactome R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-432142 R-HSA-432142 Reactome Name: Platelet sensitization by LDL See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9645135 R-HSA-9645135 Reactome Name: STAT5 Activation See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Developmental Biology Gene expression (Transcription) Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1549564 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1549564 Reaction Name: PPTN11 dephosphorylates SPRY2 See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-177923 ( R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177926 ( R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177935 ( R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177944 ( R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-186778 ( R-HSA-186763 ) R-HSA-186778 Reaction Name: SHP2 binds to the active receptor See in Reactome R-HSA-204873 ( R-HSA-210993 ) R-HSA-204873 Reaction Name: Interaction of Tie2 and Shp2 See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-210294 ( R-HSA-210990; R-HSA-432142 ) R-HSA-210294 Reaction Name: Interaction of PECAM-1 and SHP-2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-388829 ( R-HSA-388841; R-HSA-389513 ) R-HSA-388829 Reaction Name: SHP2 phosphatase binds CTLA-4 See in Reactome R-HSA-389758 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389758 Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases See in Reactome R-HSA-389759 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389759 Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1 See in Reactome R-HSA-389941 ( R-HSA-388841 ) R-HSA-389941 Reaction Name: SHP-1 and SHP-2 bind pBTLA See in Reactome R-HSA-391150 ( R-HSA-391160 ) R-HSA-391150 Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 See in Reactome R-HSA-418863 ( R-HSA-418886 ) R-HSA-418863 Reaction Name: Shp2 binds pUnc5C See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5654584 ( R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654587 ( R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654594 ( R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654607 ( R-HSA-5654700 ) R-HSA-5654607 Reaction Name: Activated FGFR2 phosphorylates PPTN11 See in Reactome R-HSA-5654608 ( R-HSA-5654700 ) R-HSA-5654608 Reaction Name: Activated FGFR2:p-FRS bind to PPTN11 See in Reactome R-HSA-5654620 ( R-HSA-5654695 ) R-HSA-5654620 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654631 ( R-HSA-5654706 ) R-HSA-5654631 Reaction Name: Activated FGFR3 phosphorylates PPTN11 See in Reactome R-HSA-5654633 ( R-HSA-5654706 ) R-HSA-5654633 Reaction Name: Activated FGFR3:p-FRS bind to PPTN11 See in Reactome R-HSA-5654641 ( R-HSA-5654710 ) R-HSA-5654641 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654655 ( R-HSA-5654712 ) R-HSA-5654655 Reaction Name: Activated FGFR4 phosphorylates PPTN11 See in Reactome R-HSA-5654658 ( R-HSA-5654712 ) R-HSA-5654658 Reaction Name: Activated FGFR4:p-FRS bind to PPTN11 See in Reactome R-HSA-5654667 ( R-HSA-5654720 ) R-HSA-5654667 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654677 ( R-HSA-5654727 ) R-HSA-5654677 Reaction Name: CBL ubiquitinates FRS2 and FGFR2 See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654729 ( R-HSA-5654727 ) R-HSA-5654729 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-5684169 ( R-HSA-114604 ) R-HSA-5684169 Reaction Name: G6B binds PTPN6,PTPN11 See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-877308 ( R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-8855508 ( R-HSA-8853659 ) R-HSA-8855508 Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8937744 ( R-HSA-8934593 ) R-HSA-8937744 Reaction Name: PTPN11 binds p-7Y-RUNX1 See in Reactome R-HSA-8937767 ( R-HSA-8934593 ) R-HSA-8937767 Reaction Name: PTPN11 dephosphorylates RUNX1 See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9008894 ( R-HSA-9008059 ) R-HSA-9008894 Reaction Name: PTPNs gene transcription and translation See in Reactome R-HSA-9031981 ( R-HSA-9028731 ) R-HSA-9031981 Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11 See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-914022 ( R-HSA-512988 ) R-HSA-914022 Reaction Name: SHP2 can recruit GRB2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9604969 ( R-HSA-9607240 ) R-HSA-9604969 Reaction Name: Active FLT3 binds PTPN11 See in Reactome R-HSA-9606784 ( R-HSA-9607240 ) R-HSA-9606784 Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 See in Reactome R-HSA-9645126 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645126 Reaction Name: Activators bind STAT5 See in Reactome R-HSA-9645134 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645134 Reaction Name: p-STAT5 dissociates from activator:STAT5 complex See in Reactome R-HSA-9645137 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645137 Reaction Name: Activator phosphorylates STAT5 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome
MONDO:0100082	PTPN11	Q06124	3.1.3.48	R-HSA-389948 R-HSA-389948 Reactome Name: PD-1 signaling See in Reactome R-HSA-418886 R-HSA-418886 Reactome Name: Netrin mediated repulsion signals See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2586552 R-HSA-2586552 Reactome Name: Signaling by Leptin See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-912694 R-HSA-912694 Reactome Name: Regulation of IFNA/IFNB signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-432142 R-HSA-432142 Reactome Name: Platelet sensitization by LDL See in Reactome R-HSA-391160 R-HSA-391160 Reactome Name: Signal regulatory protein family interactions See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-8934593 R-HSA-8934593 Reactome Name: Regulation of RUNX1 Expression and Activity See in Reactome R-HSA-909733 R-HSA-909733 Reactome Name: Interferon alpha/beta signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-1059683 R-HSA-1059683 Reactome Name: Interleukin-6 signaling See in Reactome R-HSA-9645135 R-HSA-9645135 Reactome Name: STAT5 Activation See in Reactome R-HSA-8865999 R-HSA-8865999 Reactome Name: MET activates PTPN11 See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-1170546 R-HSA-1170546 Reactome Name: Prolactin receptor signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-110056 R-HSA-110056 Reactome Name: MAPK3 (ERK1) activation See in Reactome R-HSA-8854691 R-HSA-8854691 Reactome Name: Interleukin-20 family signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-6783589 R-HSA-6783589 Reactome Name: Interleukin-6 family signaling See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Cell-Cell communication Developmental Biology Gene expression (Transcription) Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-109857 ( R-HSA-110056 ) R-HSA-109857 Reaction Name: MAP2K1 binds MAPK3 See in Reactome R-HSA-109858 ( R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-1112690 ( R-HSA-1059683 ) R-HSA-1112690 Reaction Name: PTPN11 binds CBL See in Reactome R-HSA-1112703 ( R-HSA-1059683 ) R-HSA-1112703 Reaction Name: PTPN11 is phosphorylated See in Reactome R-HSA-1112708 ( R-HSA-1059683 ) R-HSA-1112708 Reaction Name: PTPN11 binds p-Y759-IL6ST See in Reactome R-HSA-1369114 ( R-HSA-1170546 ) R-HSA-1369114 Reaction Name: PRLR binds SHP2 (PTPN11) See in Reactome R-HSA-1369115 ( R-HSA-1170546 ) R-HSA-1369115 Reaction Name: SHP2 is phosphorylated See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1549564 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1549564 Reaction Name: PPTN11 dephosphorylates SPRY2 See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-177923 ( R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177926 ( R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177935 ( R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177944 ( R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-186778 ( R-HSA-186763 ) R-HSA-186778 Reaction Name: SHP2 binds to the active receptor See in Reactome R-HSA-204873 ( R-HSA-210993 ) R-HSA-204873 Reaction Name: Interaction of Tie2 and Shp2 See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-210294 ( R-HSA-210990; R-HSA-432142 ) R-HSA-210294 Reaction Name: Interaction of PECAM-1 and SHP-2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2671742 ( R-HSA-2586552 ) R-HSA-2671742 Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin See in Reactome R-HSA-2671747 ( R-HSA-2586552 ) R-HSA-2671747 Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11) See in Reactome R-HSA-388829 ( R-HSA-388841; R-HSA-389513 ) R-HSA-388829 Reaction Name: SHP2 phosphatase binds CTLA-4 See in Reactome R-HSA-389758 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389758 Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases See in Reactome R-HSA-389759 ( R-HSA-388841; R-HSA-389948 ) R-HSA-389759 Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1 See in Reactome R-HSA-389941 ( R-HSA-388841 ) R-HSA-389941 Reaction Name: SHP-1 and SHP-2 bind pBTLA See in Reactome R-HSA-391150 ( R-HSA-391160 ) R-HSA-391150 Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 See in Reactome R-HSA-418863 ( R-HSA-418886 ) R-HSA-418863 Reaction Name: Shp2 binds pUnc5C See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5654584 ( R-HSA-5654693 ) R-HSA-5654584 Reaction Name: Activated FGFR1:p-FRS bind to PPTN11 See in Reactome R-HSA-5654587 ( R-HSA-5654693 ) R-HSA-5654587 Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11 See in Reactome R-HSA-5654594 ( R-HSA-5654689 ) R-HSA-5654594 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654607 ( R-HSA-5654700 ) R-HSA-5654607 Reaction Name: Activated FGFR2 phosphorylates PPTN11 See in Reactome R-HSA-5654608 ( R-HSA-5654700 ) R-HSA-5654608 Reaction Name: Activated FGFR2:p-FRS bind to PPTN11 See in Reactome R-HSA-5654620 ( R-HSA-5654695 ) R-HSA-5654620 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654631 ( R-HSA-5654706 ) R-HSA-5654631 Reaction Name: Activated FGFR3 phosphorylates PPTN11 See in Reactome R-HSA-5654633 ( R-HSA-5654706 ) R-HSA-5654633 Reaction Name: Activated FGFR3:p-FRS bind to PPTN11 See in Reactome R-HSA-5654641 ( R-HSA-5654710 ) R-HSA-5654641 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654655 ( R-HSA-5654712 ) R-HSA-5654655 Reaction Name: Activated FGFR4 phosphorylates PPTN11 See in Reactome R-HSA-5654658 ( R-HSA-5654712 ) R-HSA-5654658 Reaction Name: Activated FGFR4:p-FRS bind to PPTN11 See in Reactome R-HSA-5654667 ( R-HSA-5654720 ) R-HSA-5654667 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654672 ( R-HSA-5654726 ) R-HSA-5654672 Reaction Name: CBL ubiquitinates FRS2 and FGFR1 See in Reactome R-HSA-5654673 ( R-HSA-5654726 ) R-HSA-5654673 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1 See in Reactome R-HSA-5654677 ( R-HSA-5654727 ) R-HSA-5654677 Reaction Name: CBL ubiquitinates FRS2 and FGFR2 See in Reactome R-HSA-5654679 ( R-HSA-5654732 ) R-HSA-5654679 Reaction Name: CBL ubiquitinates FRS2 and FGFR3 See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654729 ( R-HSA-5654727 ) R-HSA-5654729 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2 See in Reactome R-HSA-5654730 ( R-HSA-5654732 ) R-HSA-5654730 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-5684169 ( R-HSA-114604 ) R-HSA-5684169 Reaction Name: G6B binds PTPN6,PTPN11 See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-877308 ( R-HSA-877312 ) R-HSA-877308 Reaction Name: Dephosphorylation of JAKs by PTPs See in Reactome R-HSA-8855508 ( R-HSA-8853659 ) R-HSA-8855508 Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 See in Reactome R-HSA-8865994 ( R-HSA-8865999 ) R-HSA-8865994 Reaction Name: GAB1 binds PTPN11 See in Reactome R-HSA-8937744 ( R-HSA-8934593 ) R-HSA-8937744 Reaction Name: PTPN11 binds p-7Y-RUNX1 See in Reactome R-HSA-8937767 ( R-HSA-8934593 ) R-HSA-8937767 Reaction Name: PTPN11 dephosphorylates RUNX1 See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8987014 ( R-HSA-8854691 ) R-HSA-8987014 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 See in Reactome R-HSA-8987070 ( R-HSA-8854691 ) R-HSA-8987070 Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 See in Reactome R-HSA-8987132 ( R-HSA-8854691 ) R-HSA-8987132 Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 See in Reactome R-HSA-8987236 ( R-HSA-8854691 ) R-HSA-8987236 Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 See in Reactome R-HSA-9008894 ( R-HSA-9008059 ) R-HSA-9008894 Reaction Name: PTPNs gene transcription and translation See in Reactome R-HSA-9031981 ( R-HSA-9028731 ) R-HSA-9031981 Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11 See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-909726 ( R-HSA-909733 ) R-HSA-909726 Reaction Name: Phosphorylation of STAT1 See in Reactome R-HSA-909738 ( R-HSA-512988 ) R-HSA-909738 Reaction Name: SHP1 and SHP2 bind the common beta chain See in Reactome R-HSA-914022 ( R-HSA-512988 ) R-HSA-914022 Reaction Name: SHP2 can recruit GRB2 See in Reactome R-HSA-914036 ( R-HSA-512988 ) R-HSA-914036 Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB See in Reactome R-HSA-9604969 ( R-HSA-9607240 ) R-HSA-9604969 Reaction Name: Active FLT3 binds PTPN11 See in Reactome R-HSA-9606784 ( R-HSA-9607240 ) R-HSA-9606784 Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 See in Reactome R-HSA-9645126 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645126 Reaction Name: Activators bind STAT5 See in Reactome R-HSA-9645134 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645134 Reaction Name: p-STAT5 dissociates from activator:STAT5 complex See in Reactome R-HSA-9645137 ( R-HSA-9607240; R-HSA-9645135 ) R-HSA-9645137 Reaction Name: Activator phosphorylates STAT5 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-997309 ( R-HSA-909733; R-HSA-912694 ) R-HSA-997309 Reaction Name: Dephosphorylation of STAT1 by SHP2 See in Reactome