MONDO:0000087 |
MONDO:0000087
Disease Name: polymicrogyria
Orphanet id: Orphanet:35981
All associated enzymes in DAR:
AKT3
. The disease is also associated to other non-enzyme proteins (not in DAR).
AKT3 |
Q9Y243 |
2.7.11.1
|
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1640170
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-5633007
R-HSA-194138
R-HSA-74160
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-162582
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-69242
R-HSA-212436
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109581
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Vesicle-mediated transport
Programmed Cell Death
|
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0001056 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0002407 |
AKT3 |
Q9Y243 |
2.7.11.1
|
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1640170
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-5633007
R-HSA-194138
R-HSA-74160
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-162582
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-69242
R-HSA-212436
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109581
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Vesicle-mediated transport
Programmed Cell Death
|
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0005012 |
MTOR |
P42345 |
2.7.11.1
|
R-HSA-1632852
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-1257604
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-165159
R-HSA-9639288
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-166208
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9612973
R-HSA-5633007
R-HSA-4420097
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-168256
R-HSA-2262752
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-389356
R-HSA-6807070
R-HSA-194138
R-HSA-8953897
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
Immune System
Cellular responses to stimuli
Signal Transduction
|
R-HSA-165680
(
R-HSA-165159
)
R-HSA-165680
Reaction Name: Formation of active mTORC1 complex
See in Reactome
R-HSA-165692
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165692
Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1
See in Reactome
R-HSA-165718
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165718
Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K)
See in Reactome
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-380979
(
R-HSA-165159;
R-HSA-380972;
R-HSA-5628897
)
R-HSA-380979
Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP
See in Reactome
R-HSA-447074
(
R-HSA-165159;
R-HSA-380972
)
R-HSA-447074
Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex
See in Reactome
R-HSA-5082405
(
R-HSA-3371571
)
R-HSA-5082405
Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation
See in Reactome
R-HSA-5653968
(
R-HSA-165159
)
R-HSA-5653968
Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1
See in Reactome
R-HSA-5672010
(
R-HSA-1632852
)
R-HSA-5672010
Reaction Name: Active MTORC1 phosphorylates ULK1
See in Reactome
R-HSA-5672017
(
R-HSA-1632852
)
R-HSA-5672017
Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP
See in Reactome
R-HSA-5672817
(
R-HSA-1632852
)
R-HSA-5672817
Reaction Name: Active MTORC1 binds the ULK1 complex
See in Reactome
R-HSA-5672824
(
R-HSA-165159
)
R-HSA-5672824
Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB
See in Reactome
R-HSA-5672828
(
R-HSA-165159
)
R-HSA-5672843
(
R-HSA-165159
)
R-HSA-5673768
(
R-HSA-1632852
)
R-HSA-5673768
Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
See in Reactome
R-HSA-5675790
(
R-HSA-1632852
)
R-HSA-5675790
Reaction Name: MTORC1 dissociates from ULK complex
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-8944454
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
Reaction Name: MAF1 translocates to the nucleus
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0005036 |
MTOR |
P42345 |
2.7.11.1
|
R-HSA-1632852
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-1257604
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-165159
R-HSA-9639288
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-166208
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9612973
R-HSA-5633007
R-HSA-4420097
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-168256
R-HSA-2262752
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-389356
R-HSA-6807070
R-HSA-194138
R-HSA-8953897
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
Immune System
Cellular responses to stimuli
Signal Transduction
|
R-HSA-165680
(
R-HSA-165159
)
R-HSA-165680
Reaction Name: Formation of active mTORC1 complex
See in Reactome
R-HSA-165692
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165692
Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1
See in Reactome
R-HSA-165718
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165718
Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K)
See in Reactome
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-380979
(
R-HSA-165159;
R-HSA-380972;
R-HSA-5628897
)
R-HSA-380979
Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP
See in Reactome
R-HSA-447074
(
R-HSA-165159;
R-HSA-380972
)
R-HSA-447074
Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex
See in Reactome
R-HSA-5082405
(
R-HSA-3371571
)
R-HSA-5082405
Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation
See in Reactome
R-HSA-5653968
(
R-HSA-165159
)
R-HSA-5653968
Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1
See in Reactome
R-HSA-5672010
(
R-HSA-1632852
)
R-HSA-5672010
Reaction Name: Active MTORC1 phosphorylates ULK1
See in Reactome
R-HSA-5672017
(
R-HSA-1632852
)
R-HSA-5672017
Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP
See in Reactome
R-HSA-5672817
(
R-HSA-1632852
)
R-HSA-5672817
Reaction Name: Active MTORC1 binds the ULK1 complex
See in Reactome
R-HSA-5672824
(
R-HSA-165159
)
R-HSA-5672824
Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB
See in Reactome
R-HSA-5672828
(
R-HSA-165159
)
R-HSA-5672843
(
R-HSA-165159
)
R-HSA-5673768
(
R-HSA-1632852
)
R-HSA-5673768
Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
See in Reactome
R-HSA-5675790
(
R-HSA-1632852
)
R-HSA-5675790
Reaction Name: MTORC1 dissociates from ULK complex
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-8944454
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
Reaction Name: MAF1 translocates to the nucleus
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0005148 |
AKT2 |
P31751 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-165160
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-165181
R-HSA-165181
Reactome Name: Inhibition of TSC complex formation by PKB
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-165158
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-1640170
R-HSA-74752
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5633007
R-HSA-109704
R-HSA-212436
R-HSA-74160
R-HSA-112399
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-1280218
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-73857
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109581
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-165159
R-HSA-69242
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-109703
R-HSA-9007101
R-HSA-1227986
R-HSA-8939211
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-162582
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Vesicle-mediated transport
Programmed Cell Death
Signal Transduction
|
R-HSA-109700
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165158
)
R-HSA-109702
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165158
)
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1449597
(
R-HSA-1445148
)
R-HSA-1449597
Reaction Name: p-AKT2 phosphorylates Myosin 5A
See in Reactome
R-HSA-1458463
(
R-HSA-1445148
)
R-HSA-162363
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165160
)
R-HSA-162363
Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B
See in Reactome
R-HSA-165162
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
Reaction Name: Phosphorylation of complexed TSC2 by PKB
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-389756
(
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-5260201
(
R-HSA-1445148
)
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0005233 |
AKT2 |
P31751 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-165160
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-165181
R-HSA-165181
Reactome Name: Inhibition of TSC complex formation by PKB
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-165158
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-1640170
R-HSA-74752
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5633007
R-HSA-109704
R-HSA-212436
R-HSA-74160
R-HSA-112399
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-1280218
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-73857
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109581
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-165159
R-HSA-69242
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-109703
R-HSA-9007101
R-HSA-1227986
R-HSA-8939211
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-162582
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Vesicle-mediated transport
Programmed Cell Death
Signal Transduction
|
R-HSA-109700
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165158
)
R-HSA-109702
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165158
)
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1449597
(
R-HSA-1445148
)
R-HSA-1449597
Reaction Name: p-AKT2 phosphorylates Myosin 5A
See in Reactome
R-HSA-1458463
(
R-HSA-1445148
)
R-HSA-162363
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165160
)
R-HSA-162363
Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B
See in Reactome
R-HSA-165162
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
Reaction Name: Phosphorylation of complexed TSC2 by PKB
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-389756
(
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-5260201
(
R-HSA-1445148
)
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0005335 |
AKT2 |
P31751 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-165160
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-165181
R-HSA-165181
Reactome Name: Inhibition of TSC complex formation by PKB
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-165158
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-1640170
R-HSA-74752
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5633007
R-HSA-109704
R-HSA-212436
R-HSA-74160
R-HSA-112399
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-1280218
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-73857
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109581
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-165159
R-HSA-69242
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-109703
R-HSA-9007101
R-HSA-1227986
R-HSA-8939211
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-162582
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Vesicle-mediated transport
Programmed Cell Death
Signal Transduction
|
R-HSA-109700
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165158
)
R-HSA-109702
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165158
)
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1449597
(
R-HSA-1445148
)
R-HSA-1449597
Reaction Name: p-AKT2 phosphorylates Myosin 5A
See in Reactome
R-HSA-1458463
(
R-HSA-1445148
)
R-HSA-162363
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165160
)
R-HSA-162363
Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B
See in Reactome
R-HSA-165162
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
Reaction Name: Phosphorylation of complexed TSC2 by PKB
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-389756
(
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-5260201
(
R-HSA-1445148
)
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0005335 |
MTOR |
P42345 |
2.7.11.1
|
R-HSA-1632852
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-1257604
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-165159
R-HSA-9639288
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-166208
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9612973
R-HSA-5633007
R-HSA-4420097
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-168256
R-HSA-2262752
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-389356
R-HSA-6807070
R-HSA-194138
R-HSA-8953897
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
Immune System
Cellular responses to stimuli
Signal Transduction
|
R-HSA-165680
(
R-HSA-165159
)
R-HSA-165680
Reaction Name: Formation of active mTORC1 complex
See in Reactome
R-HSA-165692
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165692
Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1
See in Reactome
R-HSA-165718
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165718
Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K)
See in Reactome
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-380979
(
R-HSA-165159;
R-HSA-380972;
R-HSA-5628897
)
R-HSA-380979
Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP
See in Reactome
R-HSA-447074
(
R-HSA-165159;
R-HSA-380972
)
R-HSA-447074
Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex
See in Reactome
R-HSA-5082405
(
R-HSA-3371571
)
R-HSA-5082405
Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation
See in Reactome
R-HSA-5653968
(
R-HSA-165159
)
R-HSA-5653968
Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1
See in Reactome
R-HSA-5672010
(
R-HSA-1632852
)
R-HSA-5672010
Reaction Name: Active MTORC1 phosphorylates ULK1
See in Reactome
R-HSA-5672017
(
R-HSA-1632852
)
R-HSA-5672017
Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP
See in Reactome
R-HSA-5672817
(
R-HSA-1632852
)
R-HSA-5672817
Reaction Name: Active MTORC1 binds the ULK1 complex
See in Reactome
R-HSA-5672824
(
R-HSA-165159
)
R-HSA-5672824
Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB
See in Reactome
R-HSA-5672828
(
R-HSA-165159
)
R-HSA-5672843
(
R-HSA-165159
)
R-HSA-5673768
(
R-HSA-1632852
)
R-HSA-5673768
Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
See in Reactome
R-HSA-5675790
(
R-HSA-1632852
)
R-HSA-5675790
Reaction Name: MTORC1 dissociates from ULK complex
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-8944454
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
Reaction Name: MAF1 translocates to the nucleus
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
AKT1 |
P31749 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-203615
R-HSA-389513
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-1257604
R-HSA-450385
R-HSA-450385
Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8849469
R-HSA-8849469
Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-354192
R-HSA-165159
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-450604
R-HSA-450604
Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA
See in Reactome
R-HSA-1474151
R-HSA-1474151
Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-8848021
R-HSA-449147
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-157118
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1640170
R-HSA-202131
R-HSA-202131
Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-5633007
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-1280218
R-HSA-69278
R-HSA-389356
R-HSA-388396
R-HSA-162582
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-194138
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-8953854
R-HSA-199991
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-8939211
R-HSA-9013694
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5653656
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-8978934
R-HSA-69206
R-HSA-6807070
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-69242
R-HSA-9614085
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109582
R-HSA-109581
|
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Metabolism of RNA
Vesicle-mediated transport
Hemostasis
|
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1497784
(
R-HSA-1474151;
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-1497784
Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
See in Reactome
R-HSA-1497796
(
R-HSA-1474151;
R-HSA-203615
)
R-HSA-1497796
Reaction Name: BH2 binding can lead to eNOS uncoupling
See in Reactome
R-HSA-1497810
(
R-HSA-203615
)
R-HSA-1497810
Reaction Name: Uncoupled eNOS favours the formation of superoxide
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-202111
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-202127
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920;
R-HSA-9009391
)
R-HSA-202137
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-202137
Reaction Name: AKT1 binds eNOS complex via HSP90
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-389756
(
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-432110
(
R-HSA-354192
)
R-HSA-432110
Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
See in Reactome
R-HSA-450490
(
R-HSA-450385
)
R-HSA-450490
Reaction Name: Protein Kinase B/Akt phosphorylates BRF1
See in Reactome
R-HSA-450499
(
R-HSA-450604
)
R-HSA-450499
Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP
See in Reactome
R-HSA-6790041
(
R-HSA-6785807
)
R-HSA-6790041
Reaction Name: Expression of STAT3-upregulated cytosolic proteins
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-6811504
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-6811504
Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma
See in Reactome
R-HSA-8848751
(
R-HSA-8849469
)
R-HSA-8848758
(
R-HSA-8849469
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9604328
(
R-HSA-9604323
)
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0005611 |
MTOR |
P42345 |
2.7.11.1
|
R-HSA-1632852
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-1257604
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-165159
R-HSA-9639288
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-166208
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9612973
R-HSA-5633007
R-HSA-4420097
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-168256
R-HSA-2262752
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-389356
R-HSA-6807070
R-HSA-194138
R-HSA-8953897
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
Immune System
Cellular responses to stimuli
Signal Transduction
|
R-HSA-165680
(
R-HSA-165159
)
R-HSA-165680
Reaction Name: Formation of active mTORC1 complex
See in Reactome
R-HSA-165692
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165692
Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1
See in Reactome
R-HSA-165718
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165718
Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K)
See in Reactome
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-380979
(
R-HSA-165159;
R-HSA-380972;
R-HSA-5628897
)
R-HSA-380979
Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP
See in Reactome
R-HSA-447074
(
R-HSA-165159;
R-HSA-380972
)
R-HSA-447074
Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex
See in Reactome
R-HSA-5082405
(
R-HSA-3371571
)
R-HSA-5082405
Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation
See in Reactome
R-HSA-5653968
(
R-HSA-165159
)
R-HSA-5653968
Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1
See in Reactome
R-HSA-5672010
(
R-HSA-1632852
)
R-HSA-5672010
Reaction Name: Active MTORC1 phosphorylates ULK1
See in Reactome
R-HSA-5672017
(
R-HSA-1632852
)
R-HSA-5672017
Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP
See in Reactome
R-HSA-5672817
(
R-HSA-1632852
)
R-HSA-5672817
Reaction Name: Active MTORC1 binds the ULK1 complex
See in Reactome
R-HSA-5672824
(
R-HSA-165159
)
R-HSA-5672824
Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB
See in Reactome
R-HSA-5672828
(
R-HSA-165159
)
R-HSA-5672843
(
R-HSA-165159
)
R-HSA-5673768
(
R-HSA-1632852
)
R-HSA-5673768
Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
See in Reactome
R-HSA-5675790
(
R-HSA-1632852
)
R-HSA-5675790
Reaction Name: MTORC1 dissociates from ULK complex
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-8944454
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
Reaction Name: MAF1 translocates to the nucleus
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0007962 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0008093 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0008170 |
AKT1 |
P31749 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-203615
R-HSA-389513
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-1257604
R-HSA-450385
R-HSA-450385
Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8849469
R-HSA-8849469
Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-354192
R-HSA-165159
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-450604
R-HSA-450604
Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA
See in Reactome
R-HSA-1474151
R-HSA-1474151
Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-8848021
R-HSA-449147
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-157118
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1640170
R-HSA-202131
R-HSA-202131
Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-5633007
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-1280218
R-HSA-69278
R-HSA-389356
R-HSA-388396
R-HSA-162582
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-194138
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-8953854
R-HSA-199991
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-8939211
R-HSA-9013694
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5653656
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-8978934
R-HSA-69206
R-HSA-6807070
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-69242
R-HSA-9614085
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109582
R-HSA-109581
|
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Metabolism of RNA
Vesicle-mediated transport
Hemostasis
|
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1497784
(
R-HSA-1474151;
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-1497784
Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
See in Reactome
R-HSA-1497796
(
R-HSA-1474151;
R-HSA-203615
)
R-HSA-1497796
Reaction Name: BH2 binding can lead to eNOS uncoupling
See in Reactome
R-HSA-1497810
(
R-HSA-203615
)
R-HSA-1497810
Reaction Name: Uncoupled eNOS favours the formation of superoxide
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-202111
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-202127
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920;
R-HSA-9009391
)
R-HSA-202137
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-202137
Reaction Name: AKT1 binds eNOS complex via HSP90
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-389756
(
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-432110
(
R-HSA-354192
)
R-HSA-432110
Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
See in Reactome
R-HSA-450490
(
R-HSA-450385
)
R-HSA-450490
Reaction Name: Protein Kinase B/Akt phosphorylates BRF1
See in Reactome
R-HSA-450499
(
R-HSA-450604
)
R-HSA-450499
Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP
See in Reactome
R-HSA-6790041
(
R-HSA-6785807
)
R-HSA-6790041
Reaction Name: Expression of STAT3-upregulated cytosolic proteins
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-6811504
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-6811504
Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma
See in Reactome
R-HSA-8848751
(
R-HSA-8849469
)
R-HSA-8848758
(
R-HSA-8849469
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9604328
(
R-HSA-9604323
)
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0008170 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0008318 |
AKT1 |
P31749 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-203615
R-HSA-389513
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-1257604
R-HSA-450385
R-HSA-450385
Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8849469
R-HSA-8849469
Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-354192
R-HSA-165159
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-450604
R-HSA-450604
Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA
See in Reactome
R-HSA-1474151
R-HSA-1474151
Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-8848021
R-HSA-449147
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-157118
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1640170
R-HSA-202131
R-HSA-202131
Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-5633007
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-1280218
R-HSA-69278
R-HSA-389356
R-HSA-388396
R-HSA-162582
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-194138
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-8953854
R-HSA-199991
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-8939211
R-HSA-9013694
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5653656
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-8978934
R-HSA-69206
R-HSA-6807070
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-69242
R-HSA-9614085
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109582
R-HSA-109581
|
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Metabolism of RNA
Vesicle-mediated transport
Hemostasis
|
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1497784
(
R-HSA-1474151;
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-1497784
Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
See in Reactome
R-HSA-1497796
(
R-HSA-1474151;
R-HSA-203615
)
R-HSA-1497796
Reaction Name: BH2 binding can lead to eNOS uncoupling
See in Reactome
R-HSA-1497810
(
R-HSA-203615
)
R-HSA-1497810
Reaction Name: Uncoupled eNOS favours the formation of superoxide
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-202111
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-202127
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920;
R-HSA-9009391
)
R-HSA-202137
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-202137
Reaction Name: AKT1 binds eNOS complex via HSP90
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-389756
(
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-432110
(
R-HSA-354192
)
R-HSA-432110
Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
See in Reactome
R-HSA-450490
(
R-HSA-450385
)
R-HSA-450490
Reaction Name: Protein Kinase B/Akt phosphorylates BRF1
See in Reactome
R-HSA-450499
(
R-HSA-450604
)
R-HSA-450499
Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP
See in Reactome
R-HSA-6790041
(
R-HSA-6785807
)
R-HSA-6790041
Reaction Name: Expression of STAT3-upregulated cytosolic proteins
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-6811504
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-6811504
Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma
See in Reactome
R-HSA-8848751
(
R-HSA-8849469
)
R-HSA-8848758
(
R-HSA-8849469
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9604328
(
R-HSA-9604323
)
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0008420 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0008903 |
MONDO:0008903
Disease Name: lung cancer
OMIM id: OMIM:614210
All associated enzymes in DAR:
ERBB2
MAP3K8
PIK3CA
MAP3K8 |
P41279 |
2.7.11.25
|
R-HSA-5684264
R-HSA-5684264
Reactome Name: MAP3K8 (TPL2)-dependent MAPK1/3 activation
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-449147
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-168256
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-1280218
R-HSA-9020702
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168898
R-HSA-389356
R-HSA-166166
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-446652
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-450294
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-448424
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
|
Immune System
|
R-HSA-389756
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-392530
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-451634
(
R-HSA-5684264
)
R-HSA-451634
Reaction Name: NFKB p105, TPL2 (COT) and ABIN2 form a stable complex
See in Reactome
R-HSA-451649
(
R-HSA-5684264
)
R-HSA-5684248
(
R-HSA-5684264
)
R-HSA-5684248
Reaction Name: SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2
See in Reactome
R-HSA-5684250
(
R-HSA-5684264
)
R-HSA-5684250
Reaction Name: SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2
See in Reactome
R-HSA-5684261
(
R-HSA-5684264
)
R-HSA-5684267
(
R-HSA-5684264
)
R-HSA-5684267
Reaction Name: IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex
See in Reactome
R-HSA-5684273
(
R-HSA-5684264
)
R-HSA-5684273
Reaction Name: 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105
See in Reactome
R-HSA-5684275
(
R-HSA-5684264
)
R-HSA-5684275
Reaction Name: IKBKB phosphorylates TPL2 (MAP3K8) at Ser400
See in Reactome
|
MONDO:0008903 |
MONDO:0008903
Disease Name: lung cancer
OMIM id: OMIM:614210
All associated enzymes in DAR:
ERBB2
MAP3K8
PIK3CA
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0009416 |
AKT2 |
P31751 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-165160
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-165181
R-HSA-165181
Reactome Name: Inhibition of TSC complex formation by PKB
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-165158
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-1640170
R-HSA-74752
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5633007
R-HSA-109704
R-HSA-212436
R-HSA-74160
R-HSA-112399
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-1280218
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-73857
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109581
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-165159
R-HSA-69242
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-109703
R-HSA-9007101
R-HSA-1227986
R-HSA-8939211
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-162582
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Vesicle-mediated transport
Programmed Cell Death
Signal Transduction
|
R-HSA-109700
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165158
)
R-HSA-109702
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165158
)
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1449597
(
R-HSA-1445148
)
R-HSA-1449597
Reaction Name: p-AKT2 phosphorylates Myosin 5A
See in Reactome
R-HSA-1458463
(
R-HSA-1445148
)
R-HSA-162363
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165160
)
R-HSA-162363
Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B
See in Reactome
R-HSA-165162
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
Reaction Name: Phosphorylation of complexed TSC2 by PKB
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-389756
(
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-5260201
(
R-HSA-1445148
)
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0011240 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0011240 |
AKT3 |
Q9Y243 |
2.7.11.1
|
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1640170
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-5633007
R-HSA-194138
R-HSA-74160
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-162582
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-69242
R-HSA-212436
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109581
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Vesicle-mediated transport
Programmed Cell Death
|
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0013038 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0013125 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0014047 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0014048 |
AKT1 |
P31749 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-203615
R-HSA-389513
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-1257604
R-HSA-450385
R-HSA-450385
Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8849469
R-HSA-8849469
Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-354192
R-HSA-165159
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-450604
R-HSA-450604
Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA
See in Reactome
R-HSA-1474151
R-HSA-1474151
Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-8848021
R-HSA-449147
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-157118
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1640170
R-HSA-202131
R-HSA-202131
Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-5633007
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-1280218
R-HSA-69278
R-HSA-389356
R-HSA-388396
R-HSA-162582
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-194138
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-8953854
R-HSA-199991
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-8939211
R-HSA-9013694
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5653656
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-8978934
R-HSA-69206
R-HSA-6807070
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-69242
R-HSA-9614085
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109582
R-HSA-109581
|
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Metabolism of RNA
Vesicle-mediated transport
Hemostasis
|
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1497784
(
R-HSA-1474151;
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-1497784
Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
See in Reactome
R-HSA-1497796
(
R-HSA-1474151;
R-HSA-203615
)
R-HSA-1497796
Reaction Name: BH2 binding can lead to eNOS uncoupling
See in Reactome
R-HSA-1497810
(
R-HSA-203615
)
R-HSA-1497810
Reaction Name: Uncoupled eNOS favours the formation of superoxide
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-202111
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-202127
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920;
R-HSA-9009391
)
R-HSA-202137
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-202137
Reaction Name: AKT1 binds eNOS complex via HSP90
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-389756
(
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-432110
(
R-HSA-354192
)
R-HSA-432110
Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
See in Reactome
R-HSA-450490
(
R-HSA-450385
)
R-HSA-450490
Reaction Name: Protein Kinase B/Akt phosphorylates BRF1
See in Reactome
R-HSA-450499
(
R-HSA-450604
)
R-HSA-450499
Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP
See in Reactome
R-HSA-6790041
(
R-HSA-6785807
)
R-HSA-6790041
Reaction Name: Expression of STAT3-upregulated cytosolic proteins
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-6811504
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-6811504
Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma
See in Reactome
R-HSA-8848751
(
R-HSA-8849469
)
R-HSA-8848758
(
R-HSA-8849469
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9604328
(
R-HSA-9604323
)
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0014334 |
LCK |
P06239 |
2.7.10.2
|
R-HSA-202433
R-HSA-202433
Reactome Name: Generation of second messenger molecules
See in Reactome
R-HSA-389948
R-HSA-1433559
R-HSA-202424
R-HSA-9020558
R-HSA-1257604
R-HSA-202427
R-HSA-202427
Reactome Name: Phosphorylation of CD3 and TCR zeta chains
See in Reactome
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-1433557
R-HSA-389513
R-HSA-9706374
R-HSA-9706374
Reactome Name: FLT3 signaling through SRC family kinases
See in Reactome
R-HSA-202430
R-HSA-202430
Reactome Name: Translocation of ZAP-70 to Immunological synapse
See in Reactome
R-HSA-2424491
R-HSA-389356
R-HSA-210990
R-HSA-389359
R-HSA-9013407
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
|
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-109582
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-9012999
R-HSA-449147
R-HSA-168256
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-451927
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9607240
R-HSA-168249
R-HSA-162582
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-2172127
R-HSA-1280218
R-HSA-202403
|
Hemostasis
Immune System
Signal Transduction
|
R-HSA-1433418
(
R-HSA-1433557
)
R-HSA-1433428
(
R-HSA-1433557
)
R-HSA-1433428
Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2
See in Reactome
R-HSA-1433451
(
R-HSA-1433557
)
R-HSA-1433454
(
R-HSA-1433557
)
R-HSA-1433454
Reaction Name: Phosphorylation of GAB2 by SFKs
See in Reactome
R-HSA-1433456
(
R-HSA-1433557
)
R-HSA-1433488
(
R-HSA-1433557
)
R-HSA-1433488
Reaction Name: Phosphorylation of SHP2 by SFKs
See in Reactome
R-HSA-1433506
(
R-HSA-1433557;
R-HSA-1433559
)
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1433542
(
R-HSA-1433557
)
R-HSA-1433542
Reaction Name: Phosphorylation and activation of VAV1
See in Reactome
R-HSA-1470009
(
R-HSA-1433557
)
R-HSA-1470010
(
R-HSA-1433557
)
R-HSA-1470012
(
R-HSA-1433557
)
R-HSA-1470012
Reaction Name: Disassociation and translocation of STATs to the nucleus
See in Reactome
R-HSA-1472121
(
R-HSA-1433557
)
R-HSA-1472121
Reaction Name: Phosphorylation of p-KIT on Y900 by Src kinases
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-202165
(
R-HSA-202427
)
R-HSA-202165
Reaction Name: Phosphorylation of ITAM motifs in CD3 complexes
See in Reactome
R-HSA-202168
(
R-HSA-202430
)
R-HSA-202168
Reaction Name: Phosphorylation of ZAP-70 by Lck
See in Reactome
R-HSA-202174
(
R-HSA-202430
)
R-HSA-202214
(
R-HSA-202427
)
R-HSA-202214
Reaction Name: Dephosphorylation of Lck-pY505 by CD45
See in Reactome
R-HSA-202216
(
R-HSA-202433
)
R-HSA-202233
(
R-HSA-202427
)
R-HSA-202245
(
R-HSA-202433
)
R-HSA-202245
Reaction Name: Phosphorylation of TBSMs in LAT
See in Reactome
R-HSA-202248
(
R-HSA-202433
)
R-HSA-202291
(
R-HSA-202427
)
R-HSA-202307
(
R-HSA-202424
)
R-HSA-202307
Reaction Name: Change of PKC theta conformation
See in Reactome
R-HSA-202344
(
R-HSA-202430
)
R-HSA-202344
Reaction Name: Recruitment of ZAP-70 to phosphorylated ITAMs
See in Reactome
R-HSA-205205
(
R-HSA-1433557
)
R-HSA-205205
Reaction Name: Interaction of Src family kinases with p-KIT
See in Reactome
R-HSA-205234
(
R-HSA-1433557
)
R-HSA-205234
Reaction Name: Indirect recruitment of GAB2 to p-KIT
See in Reactome
R-HSA-205238
(
R-HSA-1433557
)
R-HSA-205244
(
R-HSA-1433557;
R-HSA-1433559
)
R-HSA-205319
(
R-HSA-1433557;
R-HSA-1433559
)
R-HSA-210289
(
R-HSA-2424491
)
R-HSA-210291
(
R-HSA-210990
)
R-HSA-210291
Reaction Name: Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2395412
(
R-HSA-2424491
)
R-HSA-2395439
(
R-HSA-2424491
)
R-HSA-2395801
(
R-HSA-2424491
)
R-HSA-2395801
Reaction Name: Phosphorylation of LAT by p-SYK
See in Reactome
R-HSA-2396594
(
R-HSA-2424491
)
R-HSA-2396594
Reaction Name: Phosphorylation of SLP-76 by p-SYK
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2424484
(
R-HSA-2424491
)
R-HSA-2424484
Reaction Name: Phosphorylation of BTK by p-SYK
See in Reactome
R-HSA-2424486
(
R-HSA-2424491
)
R-HSA-2424486
Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK
See in Reactome
R-HSA-2424487
(
R-HSA-2424491
)
R-HSA-2424487
Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK
See in Reactome
R-HSA-388814
(
R-HSA-388841;
R-HSA-389356;
R-HSA-389359
)
R-HSA-388829
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-388831
(
R-HSA-388841;
R-HSA-389356
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-388833
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-389348
(
R-HSA-388841;
R-HSA-389356;
R-HSA-389359
)
R-HSA-389350
(
R-HSA-388841;
R-HSA-389356;
R-HSA-389359
)
R-HSA-389352
(
R-HSA-388841;
R-HSA-389356;
R-HSA-389359
)
R-HSA-389354
(
R-HSA-388841;
R-HSA-389356;
R-HSA-389359
)
R-HSA-389381
(
R-HSA-388841;
R-HSA-389356
)
R-HSA-389758
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389758
Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
See in Reactome
R-HSA-389759
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389759
Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1
See in Reactome
R-HSA-389762
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-434836
(
R-HSA-114604
)
R-HSA-452100
(
R-HSA-9020558
)
R-HSA-452100
Reaction Name: SHC1 bound to IL2 receptor is phosphorylated
See in Reactome
R-HSA-8852200
(
R-HSA-202427
)
R-HSA-8855381
(
R-HSA-202430
)
R-HSA-8857925
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-8857925
Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9706312
(
R-HSA-9607240;
R-HSA-9706374
)
|
MONDO:0014407 |
AKT3 |
Q9Y243 |
2.7.11.1
|
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1640170
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-5633007
R-HSA-194138
R-HSA-74160
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-162582
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-69242
R-HSA-212436
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109581
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Vesicle-mediated transport
Programmed Cell Death
|
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0014716 |
MTOR |
P42345 |
2.7.11.1
|
R-HSA-1632852
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-1257604
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-165159
R-HSA-9639288
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-166208
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9612973
R-HSA-5633007
R-HSA-4420097
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-168256
R-HSA-2262752
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-389356
R-HSA-6807070
R-HSA-194138
R-HSA-8953897
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
Immune System
Cellular responses to stimuli
Signal Transduction
|
R-HSA-165680
(
R-HSA-165159
)
R-HSA-165680
Reaction Name: Formation of active mTORC1 complex
See in Reactome
R-HSA-165692
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165692
Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1
See in Reactome
R-HSA-165718
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165718
Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K)
See in Reactome
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-380979
(
R-HSA-165159;
R-HSA-380972;
R-HSA-5628897
)
R-HSA-380979
Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP
See in Reactome
R-HSA-447074
(
R-HSA-165159;
R-HSA-380972
)
R-HSA-447074
Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex
See in Reactome
R-HSA-5082405
(
R-HSA-3371571
)
R-HSA-5082405
Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation
See in Reactome
R-HSA-5653968
(
R-HSA-165159
)
R-HSA-5653968
Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1
See in Reactome
R-HSA-5672010
(
R-HSA-1632852
)
R-HSA-5672010
Reaction Name: Active MTORC1 phosphorylates ULK1
See in Reactome
R-HSA-5672017
(
R-HSA-1632852
)
R-HSA-5672017
Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP
See in Reactome
R-HSA-5672817
(
R-HSA-1632852
)
R-HSA-5672817
Reaction Name: Active MTORC1 binds the ULK1 complex
See in Reactome
R-HSA-5672824
(
R-HSA-165159
)
R-HSA-5672824
Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB
See in Reactome
R-HSA-5672828
(
R-HSA-165159
)
R-HSA-5672843
(
R-HSA-165159
)
R-HSA-5673768
(
R-HSA-1632852
)
R-HSA-5673768
Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
See in Reactome
R-HSA-5675790
(
R-HSA-1632852
)
R-HSA-5675790
Reaction Name: MTORC1 dissociates from ULK complex
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-8944454
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
Reaction Name: MAF1 translocates to the nucleus
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0016216 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0016419 |
AKT1 |
P31749 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-203615
R-HSA-389513
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-1257604
R-HSA-450385
R-HSA-450385
Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8849469
R-HSA-8849469
Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-354192
R-HSA-165159
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-450604
R-HSA-450604
Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA
See in Reactome
R-HSA-1474151
R-HSA-1474151
Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-8848021
R-HSA-449147
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-157118
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1640170
R-HSA-202131
R-HSA-202131
Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-5633007
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-1280218
R-HSA-69278
R-HSA-389356
R-HSA-388396
R-HSA-162582
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-194138
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-8953854
R-HSA-199991
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-8939211
R-HSA-9013694
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5653656
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-8978934
R-HSA-69206
R-HSA-6807070
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-69242
R-HSA-9614085
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109582
R-HSA-109581
|
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Metabolism of RNA
Vesicle-mediated transport
Hemostasis
|
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1497784
(
R-HSA-1474151;
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-1497784
Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
See in Reactome
R-HSA-1497796
(
R-HSA-1474151;
R-HSA-203615
)
R-HSA-1497796
Reaction Name: BH2 binding can lead to eNOS uncoupling
See in Reactome
R-HSA-1497810
(
R-HSA-203615
)
R-HSA-1497810
Reaction Name: Uncoupled eNOS favours the formation of superoxide
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-202111
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-202127
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920;
R-HSA-9009391
)
R-HSA-202137
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-202137
Reaction Name: AKT1 binds eNOS complex via HSP90
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-389756
(
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-432110
(
R-HSA-354192
)
R-HSA-432110
Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
See in Reactome
R-HSA-450490
(
R-HSA-450385
)
R-HSA-450490
Reaction Name: Protein Kinase B/Akt phosphorylates BRF1
See in Reactome
R-HSA-450499
(
R-HSA-450604
)
R-HSA-450499
Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP
See in Reactome
R-HSA-6790041
(
R-HSA-6785807
)
R-HSA-6790041
Reaction Name: Expression of STAT3-upregulated cytosolic proteins
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-6811504
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-6811504
Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma
See in Reactome
R-HSA-8848751
(
R-HSA-8849469
)
R-HSA-8848758
(
R-HSA-8849469
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9604328
(
R-HSA-9604323
)
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0016419 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0016642 |
AKT1 |
P31749 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-203615
R-HSA-389513
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-1257604
R-HSA-450385
R-HSA-450385
Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8849469
R-HSA-8849469
Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-354192
R-HSA-165159
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-450604
R-HSA-450604
Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA
See in Reactome
R-HSA-1474151
R-HSA-1474151
Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-8848021
R-HSA-449147
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-157118
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1640170
R-HSA-202131
R-HSA-202131
Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-5633007
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-1280218
R-HSA-69278
R-HSA-389356
R-HSA-388396
R-HSA-162582
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-194138
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-8953854
R-HSA-199991
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-8939211
R-HSA-9013694
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5653656
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-8978934
R-HSA-69206
R-HSA-6807070
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-69242
R-HSA-9614085
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109582
R-HSA-109581
|
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Metabolism of RNA
Vesicle-mediated transport
Hemostasis
|
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1497784
(
R-HSA-1474151;
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-1497784
Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
See in Reactome
R-HSA-1497796
(
R-HSA-1474151;
R-HSA-203615
)
R-HSA-1497796
Reaction Name: BH2 binding can lead to eNOS uncoupling
See in Reactome
R-HSA-1497810
(
R-HSA-203615
)
R-HSA-1497810
Reaction Name: Uncoupled eNOS favours the formation of superoxide
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-202111
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-202127
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920;
R-HSA-9009391
)
R-HSA-202137
(
R-HSA-203615;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-202137
Reaction Name: AKT1 binds eNOS complex via HSP90
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-389756
(
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-432110
(
R-HSA-354192
)
R-HSA-432110
Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
See in Reactome
R-HSA-450490
(
R-HSA-450385
)
R-HSA-450490
Reaction Name: Protein Kinase B/Akt phosphorylates BRF1
See in Reactome
R-HSA-450499
(
R-HSA-450604
)
R-HSA-450499
Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP
See in Reactome
R-HSA-6790041
(
R-HSA-6785807
)
R-HSA-6790041
Reaction Name: Expression of STAT3-upregulated cytosolic proteins
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-6811504
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-6811504
Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma
See in Reactome
R-HSA-8848751
(
R-HSA-8849469
)
R-HSA-8848758
(
R-HSA-8849469
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9604328
(
R-HSA-9604323
)
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0016642 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0017101 |
MTOR |
P42345 |
2.7.11.1
|
R-HSA-1632852
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-1257604
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-165159
R-HSA-9639288
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-166208
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9612973
R-HSA-5633007
R-HSA-4420097
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-168256
R-HSA-2262752
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-389356
R-HSA-6807070
R-HSA-194138
R-HSA-8953897
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
Immune System
Cellular responses to stimuli
Signal Transduction
|
R-HSA-165680
(
R-HSA-165159
)
R-HSA-165680
Reaction Name: Formation of active mTORC1 complex
See in Reactome
R-HSA-165692
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165692
Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1
See in Reactome
R-HSA-165718
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165718
Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K)
See in Reactome
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-380979
(
R-HSA-165159;
R-HSA-380972;
R-HSA-5628897
)
R-HSA-380979
Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP
See in Reactome
R-HSA-447074
(
R-HSA-165159;
R-HSA-380972
)
R-HSA-447074
Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex
See in Reactome
R-HSA-5082405
(
R-HSA-3371571
)
R-HSA-5082405
Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation
See in Reactome
R-HSA-5653968
(
R-HSA-165159
)
R-HSA-5653968
Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1
See in Reactome
R-HSA-5672010
(
R-HSA-1632852
)
R-HSA-5672010
Reaction Name: Active MTORC1 phosphorylates ULK1
See in Reactome
R-HSA-5672017
(
R-HSA-1632852
)
R-HSA-5672017
Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP
See in Reactome
R-HSA-5672817
(
R-HSA-1632852
)
R-HSA-5672817
Reaction Name: Active MTORC1 binds the ULK1 complex
See in Reactome
R-HSA-5672824
(
R-HSA-165159
)
R-HSA-5672824
Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB
See in Reactome
R-HSA-5672828
(
R-HSA-165159
)
R-HSA-5672843
(
R-HSA-165159
)
R-HSA-5673768
(
R-HSA-1632852
)
R-HSA-5673768
Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
See in Reactome
R-HSA-5675790
(
R-HSA-1632852
)
R-HSA-5675790
Reaction Name: MTORC1 dissociates from ULK complex
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-8944454
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
Reaction Name: MAF1 translocates to the nucleus
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0017102 |
MTOR |
P42345 |
2.7.11.1
|
R-HSA-1632852
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-1257604
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-165159
R-HSA-9639288
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-166208
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9612973
R-HSA-5633007
R-HSA-4420097
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-168256
R-HSA-2262752
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-389356
R-HSA-6807070
R-HSA-194138
R-HSA-8953897
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
Immune System
Cellular responses to stimuli
Signal Transduction
|
R-HSA-165680
(
R-HSA-165159
)
R-HSA-165680
Reaction Name: Formation of active mTORC1 complex
See in Reactome
R-HSA-165692
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165692
Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1
See in Reactome
R-HSA-165718
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165718
Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K)
See in Reactome
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-380979
(
R-HSA-165159;
R-HSA-380972;
R-HSA-5628897
)
R-HSA-380979
Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP
See in Reactome
R-HSA-447074
(
R-HSA-165159;
R-HSA-380972
)
R-HSA-447074
Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex
See in Reactome
R-HSA-5082405
(
R-HSA-3371571
)
R-HSA-5082405
Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation
See in Reactome
R-HSA-5653968
(
R-HSA-165159
)
R-HSA-5653968
Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1
See in Reactome
R-HSA-5672010
(
R-HSA-1632852
)
R-HSA-5672010
Reaction Name: Active MTORC1 phosphorylates ULK1
See in Reactome
R-HSA-5672017
(
R-HSA-1632852
)
R-HSA-5672017
Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP
See in Reactome
R-HSA-5672817
(
R-HSA-1632852
)
R-HSA-5672817
Reaction Name: Active MTORC1 binds the ULK1 complex
See in Reactome
R-HSA-5672824
(
R-HSA-165159
)
R-HSA-5672824
Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB
See in Reactome
R-HSA-5672828
(
R-HSA-165159
)
R-HSA-5672843
(
R-HSA-165159
)
R-HSA-5673768
(
R-HSA-1632852
)
R-HSA-5673768
Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
See in Reactome
R-HSA-5675790
(
R-HSA-1632852
)
R-HSA-5675790
Reaction Name: MTORC1 dissociates from ULK complex
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-8944454
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
Reaction Name: MAF1 translocates to the nucleus
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0017177 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0017564 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0017566 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0017812 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0017884 |
MTOR |
P42345 |
2.7.11.1
|
R-HSA-1632852
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-1257604
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-165159
R-HSA-9639288
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-166208
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9612973
R-HSA-5633007
R-HSA-4420097
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-168256
R-HSA-2262752
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-389356
R-HSA-6807070
R-HSA-194138
R-HSA-8953897
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
Immune System
Cellular responses to stimuli
Signal Transduction
|
R-HSA-165680
(
R-HSA-165159
)
R-HSA-165680
Reaction Name: Formation of active mTORC1 complex
See in Reactome
R-HSA-165692
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165692
Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1
See in Reactome
R-HSA-165718
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165718
Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K)
See in Reactome
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-380979
(
R-HSA-165159;
R-HSA-380972;
R-HSA-5628897
)
R-HSA-380979
Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP
See in Reactome
R-HSA-447074
(
R-HSA-165159;
R-HSA-380972
)
R-HSA-447074
Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex
See in Reactome
R-HSA-5082405
(
R-HSA-3371571
)
R-HSA-5082405
Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation
See in Reactome
R-HSA-5653968
(
R-HSA-165159
)
R-HSA-5653968
Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1
See in Reactome
R-HSA-5672010
(
R-HSA-1632852
)
R-HSA-5672010
Reaction Name: Active MTORC1 phosphorylates ULK1
See in Reactome
R-HSA-5672017
(
R-HSA-1632852
)
R-HSA-5672017
Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP
See in Reactome
R-HSA-5672817
(
R-HSA-1632852
)
R-HSA-5672817
Reaction Name: Active MTORC1 binds the ULK1 complex
See in Reactome
R-HSA-5672824
(
R-HSA-165159
)
R-HSA-5672824
Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB
See in Reactome
R-HSA-5672828
(
R-HSA-165159
)
R-HSA-5672843
(
R-HSA-165159
)
R-HSA-5673768
(
R-HSA-1632852
)
R-HSA-5673768
Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
See in Reactome
R-HSA-5675790
(
R-HSA-1632852
)
R-HSA-5675790
Reaction Name: MTORC1 dissociates from ULK complex
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-8944454
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
Reaction Name: MAF1 translocates to the nucleus
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0018177 |
MTOR |
P42345 |
2.7.11.1
|
R-HSA-1632852
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-1257604
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-165159
R-HSA-9639288
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-166208
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9612973
R-HSA-5633007
R-HSA-4420097
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-168256
R-HSA-2262752
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-389356
R-HSA-6807070
R-HSA-194138
R-HSA-8953897
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
Immune System
Cellular responses to stimuli
Signal Transduction
|
R-HSA-165680
(
R-HSA-165159
)
R-HSA-165680
Reaction Name: Formation of active mTORC1 complex
See in Reactome
R-HSA-165692
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165692
Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1
See in Reactome
R-HSA-165718
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165718
Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K)
See in Reactome
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-380979
(
R-HSA-165159;
R-HSA-380972;
R-HSA-5628897
)
R-HSA-380979
Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP
See in Reactome
R-HSA-447074
(
R-HSA-165159;
R-HSA-380972
)
R-HSA-447074
Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex
See in Reactome
R-HSA-5082405
(
R-HSA-3371571
)
R-HSA-5082405
Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation
See in Reactome
R-HSA-5653968
(
R-HSA-165159
)
R-HSA-5653968
Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1
See in Reactome
R-HSA-5672010
(
R-HSA-1632852
)
R-HSA-5672010
Reaction Name: Active MTORC1 phosphorylates ULK1
See in Reactome
R-HSA-5672017
(
R-HSA-1632852
)
R-HSA-5672017
Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP
See in Reactome
R-HSA-5672817
(
R-HSA-1632852
)
R-HSA-5672817
Reaction Name: Active MTORC1 binds the ULK1 complex
See in Reactome
R-HSA-5672824
(
R-HSA-165159
)
R-HSA-5672824
Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB
See in Reactome
R-HSA-5672828
(
R-HSA-165159
)
R-HSA-5672843
(
R-HSA-165159
)
R-HSA-5673768
(
R-HSA-1632852
)
R-HSA-5673768
Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
See in Reactome
R-HSA-5675790
(
R-HSA-1632852
)
R-HSA-5675790
Reaction Name: MTORC1 dissociates from ULK complex
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-8944454
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
Reaction Name: MAF1 translocates to the nucleus
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0018642 |
MAP3K14 |
Q99558 |
2.7.11.25
|
R-HSA-5607761
R-HSA-5607761
Reactome Name: Dectin-1 mediated noncanonical NF-kB signaling
See in Reactome
R-HSA-5668541
R-HSA-5668541
Reactome Name: TNFR2 non-canonical NF-kB pathway
See in Reactome
R-HSA-5676590
R-HSA-5676590
Reactome Name: NIK-->noncanonical NF-kB signaling
See in Reactome
R-HSA-5676594
R-HSA-5676594
Reactome Name: TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-168256
R-HSA-168249
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-5607764
R-HSA-389356
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
|
Immune System
|
R-HSA-392530
(
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-5607720
(
R-HSA-5607761;
R-HSA-5668541;
R-HSA-5676590
)
R-HSA-5607720
Reaction Name: p100:RELB binds active NIK:p-IKKA dimer
See in Reactome
R-HSA-5607721
(
R-HSA-5607761;
R-HSA-5668541;
R-HSA-5676590
)
R-HSA-5607722
(
R-HSA-5607761;
R-HSA-5668541;
R-HSA-5676590
)
R-HSA-5607722
Reaction Name: Active NIK phosphorylates IKKA dimer
See in Reactome
R-HSA-5607723
(
R-HSA-5607761;
R-HSA-5668541;
R-HSA-5676590
)
R-HSA-5607723
Reaction Name: SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB
See in Reactome
R-HSA-5607725
(
R-HSA-5607761;
R-HSA-5668541;
R-HSA-5676590
)
R-HSA-5607725
Reaction Name: SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP
See in Reactome
R-HSA-5607726
(
R-HSA-5607761;
R-HSA-5668541;
R-HSA-5676590
)
R-HSA-5607726
Reaction Name: Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB
See in Reactome
R-HSA-5668414
(
R-HSA-5668541
)
R-HSA-5668414
Reaction Name: TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK
See in Reactome
R-HSA-5668417
(
R-HSA-5668541
)
R-HSA-5668417
Reaction Name: cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer
See in Reactome
R-HSA-5668454
(
R-HSA-5668541
)
R-HSA-5668454
Reaction Name: K63polyUb-cIAP1,2 ubiquitinates TRAF3
See in Reactome
R-HSA-5668481
(
R-HSA-5668541
)
R-HSA-5668481
Reaction Name: Protesomal degradation of K48polyUb-TRAF3
See in Reactome
R-HSA-5668520
(
R-HSA-5668541
)
R-HSA-5668520
Reaction Name: 26Sproteasome degrades K48polyUb-NIK
See in Reactome
R-HSA-5668534
(
R-HSA-5668541
)
R-HSA-5668534
Reaction Name: cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK
See in Reactome
R-HSA-5668543
(
R-HSA-5668541
)
R-HSA-5668545
(
R-HSA-5668541;
R-HSA-5676590
)
R-HSA-5668545
Reaction Name: NIK autophosphorylates on T559
See in Reactome
R-HSA-5676593
(
R-HSA-5668541;
R-HSA-5676594
)
R-HSA-5676593
Reaction Name: TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR
See in Reactome
R-HSA-5676595
(
R-HSA-5668541;
R-HSA-5676594
)
R-HSA-5676596
(
R-HSA-5668541;
R-HSA-5676594
)
R-HSA-5676597
(
R-HSA-5668541;
R-HSA-5676594
)
R-HSA-5676597
Reaction Name: TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40
See in Reactome
R-HSA-5676598
(
R-HSA-5668541;
R-HSA-5676594
)
R-HSA-5676598
Reaction Name: TRAF2:cIAP1/2 complex binds FN14:TWEAK
See in Reactome
|
MONDO:0019192 |
AKT2 |
P31751 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-165160
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-165181
R-HSA-165181
Reactome Name: Inhibition of TSC complex formation by PKB
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-165158
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-1640170
R-HSA-74752
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5633007
R-HSA-109704
R-HSA-212436
R-HSA-74160
R-HSA-112399
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-1280218
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-73857
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109581
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-165159
R-HSA-69242
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-109703
R-HSA-9007101
R-HSA-1227986
R-HSA-8939211
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-162582
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Vesicle-mediated transport
Programmed Cell Death
Signal Transduction
|
R-HSA-109700
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165158
)
R-HSA-109702
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165158
)
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1449597
(
R-HSA-1445148
)
R-HSA-1449597
Reaction Name: p-AKT2 phosphorylates Myosin 5A
See in Reactome
R-HSA-1458463
(
R-HSA-1445148
)
R-HSA-162363
(
R-HSA-109704;
R-HSA-112399;
R-HSA-165160
)
R-HSA-162363
Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B
See in Reactome
R-HSA-165162
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
Reaction Name: Phosphorylation of complexed TSC2 by PKB
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-389756
(
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-5260201
(
R-HSA-1445148
)
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0020492 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0020492 |
MTOR |
P42345 |
2.7.11.1
|
R-HSA-1632852
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-1257604
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-165159
R-HSA-9639288
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-166208
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9612973
R-HSA-5633007
R-HSA-4420097
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-168256
R-HSA-2262752
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-389356
R-HSA-6807070
R-HSA-194138
R-HSA-8953897
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
Immune System
Cellular responses to stimuli
Signal Transduction
|
R-HSA-165680
(
R-HSA-165159
)
R-HSA-165680
Reaction Name: Formation of active mTORC1 complex
See in Reactome
R-HSA-165692
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165692
Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1
See in Reactome
R-HSA-165718
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165718
Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K)
See in Reactome
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-380979
(
R-HSA-165159;
R-HSA-380972;
R-HSA-5628897
)
R-HSA-380979
Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP
See in Reactome
R-HSA-447074
(
R-HSA-165159;
R-HSA-380972
)
R-HSA-447074
Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex
See in Reactome
R-HSA-5082405
(
R-HSA-3371571
)
R-HSA-5082405
Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation
See in Reactome
R-HSA-5653968
(
R-HSA-165159
)
R-HSA-5653968
Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1
See in Reactome
R-HSA-5672010
(
R-HSA-1632852
)
R-HSA-5672010
Reaction Name: Active MTORC1 phosphorylates ULK1
See in Reactome
R-HSA-5672017
(
R-HSA-1632852
)
R-HSA-5672017
Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP
See in Reactome
R-HSA-5672817
(
R-HSA-1632852
)
R-HSA-5672817
Reaction Name: Active MTORC1 binds the ULK1 complex
See in Reactome
R-HSA-5672824
(
R-HSA-165159
)
R-HSA-5672824
Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB
See in Reactome
R-HSA-5672828
(
R-HSA-165159
)
R-HSA-5672843
(
R-HSA-165159
)
R-HSA-5673768
(
R-HSA-1632852
)
R-HSA-5673768
Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
See in Reactome
R-HSA-5675790
(
R-HSA-1632852
)
R-HSA-5675790
Reaction Name: MTORC1 dissociates from ULK complex
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-8944454
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
Reaction Name: MAF1 translocates to the nucleus
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0020492 |
AKT3 |
Q9Y243 |
2.7.11.1
|
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1640170
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-5633007
R-HSA-194138
R-HSA-74160
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-162582
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-69242
R-HSA-212436
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109581
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Vesicle-mediated transport
Programmed Cell Death
|
R-HSA-1358791
(
R-HSA-1358803
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0021100 |
MONDO:0021100
Disease Name: breast neoplasm
All associated enzymes in DAR:
FGFR2
MTOR
FGFR4
ROCK1
RHOA
MTOR |
P42345 |
2.7.11.1
|
R-HSA-1632852
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-1257604
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-165159
R-HSA-9639288
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-166208
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9612973
R-HSA-5633007
R-HSA-4420097
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-168256
R-HSA-2262752
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-389356
R-HSA-6807070
R-HSA-194138
R-HSA-8953897
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
Immune System
Cellular responses to stimuli
Signal Transduction
|
R-HSA-165680
(
R-HSA-165159
)
R-HSA-165680
Reaction Name: Formation of active mTORC1 complex
See in Reactome
R-HSA-165692
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165692
Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1
See in Reactome
R-HSA-165718
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165718
Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K)
See in Reactome
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-380979
(
R-HSA-165159;
R-HSA-380972;
R-HSA-5628897
)
R-HSA-380979
Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP
See in Reactome
R-HSA-447074
(
R-HSA-165159;
R-HSA-380972
)
R-HSA-447074
Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex
See in Reactome
R-HSA-5082405
(
R-HSA-3371571
)
R-HSA-5082405
Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation
See in Reactome
R-HSA-5653968
(
R-HSA-165159
)
R-HSA-5653968
Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1
See in Reactome
R-HSA-5672010
(
R-HSA-1632852
)
R-HSA-5672010
Reaction Name: Active MTORC1 phosphorylates ULK1
See in Reactome
R-HSA-5672017
(
R-HSA-1632852
)
R-HSA-5672017
Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP
See in Reactome
R-HSA-5672817
(
R-HSA-1632852
)
R-HSA-5672817
Reaction Name: Active MTORC1 binds the ULK1 complex
See in Reactome
R-HSA-5672824
(
R-HSA-165159
)
R-HSA-5672824
Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB
See in Reactome
R-HSA-5672828
(
R-HSA-165159
)
R-HSA-5672843
(
R-HSA-165159
)
R-HSA-5673768
(
R-HSA-1632852
)
R-HSA-5673768
Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
See in Reactome
R-HSA-5675790
(
R-HSA-1632852
)
R-HSA-5675790
Reaction Name: MTORC1 dissociates from ULK complex
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-8944454
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
Reaction Name: MAF1 translocates to the nucleus
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0021230 |
MTOR |
P42345 |
2.7.11.1
|
R-HSA-1632852
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-1257604
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-165159
R-HSA-9639288
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-166208
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9612973
R-HSA-5633007
R-HSA-4420097
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-168256
R-HSA-2262752
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-389356
R-HSA-6807070
R-HSA-194138
R-HSA-8953897
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
Immune System
Cellular responses to stimuli
Signal Transduction
|
R-HSA-165680
(
R-HSA-165159
)
R-HSA-165680
Reaction Name: Formation of active mTORC1 complex
See in Reactome
R-HSA-165692
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165692
Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1
See in Reactome
R-HSA-165718
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165718
Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K)
See in Reactome
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-380979
(
R-HSA-165159;
R-HSA-380972;
R-HSA-5628897
)
R-HSA-380979
Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP
See in Reactome
R-HSA-447074
(
R-HSA-165159;
R-HSA-380972
)
R-HSA-447074
Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex
See in Reactome
R-HSA-5082405
(
R-HSA-3371571
)
R-HSA-5082405
Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation
See in Reactome
R-HSA-5653968
(
R-HSA-165159
)
R-HSA-5653968
Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1
See in Reactome
R-HSA-5672010
(
R-HSA-1632852
)
R-HSA-5672010
Reaction Name: Active MTORC1 phosphorylates ULK1
See in Reactome
R-HSA-5672017
(
R-HSA-1632852
)
R-HSA-5672017
Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP
See in Reactome
R-HSA-5672817
(
R-HSA-1632852
)
R-HSA-5672817
Reaction Name: Active MTORC1 binds the ULK1 complex
See in Reactome
R-HSA-5672824
(
R-HSA-165159
)
R-HSA-5672824
Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB
See in Reactome
R-HSA-5672828
(
R-HSA-165159
)
R-HSA-5672843
(
R-HSA-165159
)
R-HSA-5673768
(
R-HSA-1632852
)
R-HSA-5673768
Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
See in Reactome
R-HSA-5675790
(
R-HSA-1632852
)
R-HSA-5675790
Reaction Name: MTORC1 dissociates from ULK complex
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-8944454
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
Reaction Name: MAF1 translocates to the nucleus
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0032908 |
MONDO:0032908
Disease Name: CEBALID syndrome
OMIM id: OMIM:618774
All associated enzymes in DAR:
MTOR
. The disease is also associated to other non-enzyme proteins (not in DAR).
MTOR |
P42345 |
2.7.11.1
|
R-HSA-1632852
R-HSA-380972
R-HSA-380972
Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK
See in Reactome
R-HSA-1257604
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-165159
R-HSA-9639288
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-3371571
R-HSA-3371571
Reactome Name: HSF1-dependent transactivation
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-166208
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-9612973
R-HSA-5633007
R-HSA-4420097
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-74160
R-HSA-168256
R-HSA-2262752
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-389356
R-HSA-6807070
R-HSA-194138
R-HSA-8953897
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Autophagy
Gene expression (Transcription)
Immune System
Cellular responses to stimuli
Signal Transduction
|
R-HSA-165680
(
R-HSA-165159
)
R-HSA-165680
Reaction Name: Formation of active mTORC1 complex
See in Reactome
R-HSA-165692
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165692
Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1
See in Reactome
R-HSA-165718
(
R-HSA-165159;
R-HSA-166208
)
R-HSA-165718
Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K)
See in Reactome
R-HSA-198640
(
R-HSA-1257604;
R-HSA-388841;
R-HSA-389356;
R-HSA-389357;
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-380979
(
R-HSA-165159;
R-HSA-380972;
R-HSA-5628897
)
R-HSA-380979
Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP
See in Reactome
R-HSA-447074
(
R-HSA-165159;
R-HSA-380972
)
R-HSA-447074
Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex
See in Reactome
R-HSA-5082405
(
R-HSA-3371571
)
R-HSA-5082405
Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation
See in Reactome
R-HSA-5653968
(
R-HSA-165159
)
R-HSA-5653968
Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1
See in Reactome
R-HSA-5672010
(
R-HSA-1632852
)
R-HSA-5672010
Reaction Name: Active MTORC1 phosphorylates ULK1
See in Reactome
R-HSA-5672017
(
R-HSA-1632852
)
R-HSA-5672017
Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP
See in Reactome
R-HSA-5672817
(
R-HSA-1632852
)
R-HSA-5672817
Reaction Name: Active MTORC1 binds the ULK1 complex
See in Reactome
R-HSA-5672824
(
R-HSA-165159
)
R-HSA-5672824
Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB
See in Reactome
R-HSA-5672828
(
R-HSA-165159
)
R-HSA-5672843
(
R-HSA-165159
)
R-HSA-5673768
(
R-HSA-1632852
)
R-HSA-5673768
Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
See in Reactome
R-HSA-5675790
(
R-HSA-1632852
)
R-HSA-5675790
Reaction Name: MTORC1 dissociates from ULK complex
See in Reactome
R-HSA-6795290
(
R-HSA-6804757
)
R-HSA-6795290
Reaction Name: TORC2 complex phosphorylates SGK1
See in Reactome
R-HSA-8944454
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
(
R-HSA-1257604;
R-HSA-8943724
)
R-HSA-8944457
Reaction Name: MAF1 translocates to the nucleus
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|