DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-382556)

Number of enzymes:	12
Number of disease:	31
Number of reactomes:	83
Number of reactions:	159

Search results (Reactome ID: R-HSA-382556)

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DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007088	VCP	P55072	3.6.4.6	R-HSA-3371511 R-HSA-3371511 Reactome Name: HSF1 activation See in Reactome R-HSA-9646399 R-HSA-9646399 Reactome Name: Aggrephagy See in Reactome R-HSA-110320 R-HSA-110320 Reactome Name: Translesion Synthesis by POLH See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-532668 R-HSA-532668 Reactome Name: N-glycan trimming in the ER and Calnexin/Calreticulin cycle See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8876725 R-HSA-8876725 Reactome Name: Protein methylation See in Reactome R-HSA-8866654 R-HSA-8866654 Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins See in Reactome R-HSA-5689877 R-HSA-5689877 Reactome Name: Josephin domain DUBs See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	Immune System Transport of small molecules Cellular responses to stimuli Autophagy Metabolism of proteins DNA Repair Signal Transduction	R-HSA-5324632 ( R-HSA-3371511 ) R-HSA-5324632 Reaction Name: Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates See in Reactome R-HSA-5362412 ( R-HSA-5358346 ) R-HSA-5362412 Reaction Name: SYVN1 ubiquitinates Hh C-terminal fragments See in Reactome R-HSA-5362441 ( R-HSA-5358346 ) R-HSA-5362441 Reaction Name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane See in Reactome R-HSA-5362459 ( R-HSA-5358346 ) R-HSA-5362459 Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol See in Reactome R-HSA-5654985 ( R-HSA-110320 ) R-HSA-5654985 Reaction Name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH See in Reactome R-HSA-5654989 ( R-HSA-110320 ) R-HSA-5654989 Reaction Name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA See in Reactome R-HSA-5688834 ( R-HSA-5689877 ) R-HSA-5688834 Reaction Name: ATXN3 binds VCP See in Reactome R-HSA-6781953 ( R-HSA-5689896 ) R-HSA-6781953 Reaction Name: YOD1 binds VCP See in Reactome R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-8850594 ( R-HSA-532668 ) R-HSA-8850594 Reaction Name: Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins See in Reactome R-HSA-8866542 ( R-HSA-382556 ) R-HSA-8866542 Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol See in Reactome R-HSA-8866546 ( R-HSA-382556 ) R-HSA-8866546 Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR See in Reactome R-HSA-8866551 ( R-HSA-382556 ) R-HSA-8866551 Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation See in Reactome R-HSA-8932276 ( R-HSA-8876725 ) R-HSA-8932276 Reaction Name: VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP See in Reactome R-HSA-8943080 ( R-HSA-8866654 ) R-HSA-8943080 Reaction Name: TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11 See in Reactome R-HSA-8943083 ( R-HSA-8866654 ) R-HSA-8943083 Reaction Name: US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome R-HSA-9646347 ( R-HSA-9646399 ) R-HSA-9646347 Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1 See in Reactome R-HSA-9646354 ( R-HSA-9646399 ) R-HSA-9646354 Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex See in Reactome R-HSA-9755507 () R-HSA-9755507 Reaction Name: UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex See in Reactome R-HSA-9758088 () R-HSA-9758088 Reaction Name: UBXN7 binds VCP hexamer:UBF1:NPLOC4 See in Reactome R-HSA-9758090 () R-HSA-9758090 Reaction Name: Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation See in Reactome
MONDO:0007932	ABCA4	P78363	7.6.2.1	R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-2453902 R-HSA-2453902 Reactome Name: The canonical retinoid cycle in rods (twilight vision) See in Reactome	R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Sensory Perception Transport of small molecules	R-HSA-1467466 ( R-HSA-2453902; R-HSA-382556 ) R-HSA-1467466 Reaction Name: ABCA4 mediates atRAL transport See in Reactome R-HSA-2466749 ( R-HSA-2453902 ) R-HSA-2466749 Reaction Name: ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol See in Reactome
MONDO:0008178	VCP	P55072	3.6.4.6	R-HSA-3371511 R-HSA-3371511 Reactome Name: HSF1 activation See in Reactome R-HSA-9646399 R-HSA-9646399 Reactome Name: Aggrephagy See in Reactome R-HSA-110320 R-HSA-110320 Reactome Name: Translesion Synthesis by POLH See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-532668 R-HSA-532668 Reactome Name: N-glycan trimming in the ER and Calnexin/Calreticulin cycle See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-8876725 R-HSA-8876725 Reactome Name: Protein methylation See in Reactome R-HSA-8866654 R-HSA-8866654 Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins See in Reactome R-HSA-5689877 R-HSA-5689877 Reactome Name: Josephin domain DUBs See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	Immune System Transport of small molecules Cellular responses to stimuli Autophagy Metabolism of proteins DNA Repair Signal Transduction	R-HSA-5324632 ( R-HSA-3371511 ) R-HSA-5324632 Reaction Name: Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates See in Reactome R-HSA-5362412 ( R-HSA-5358346 ) R-HSA-5362412 Reaction Name: SYVN1 ubiquitinates Hh C-terminal fragments See in Reactome R-HSA-5362441 ( R-HSA-5358346 ) R-HSA-5362441 Reaction Name: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane See in Reactome R-HSA-5362459 ( R-HSA-5358346 ) R-HSA-5362459 Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol See in Reactome R-HSA-5654985 ( R-HSA-110320 ) R-HSA-5654985 Reaction Name: SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH See in Reactome R-HSA-5654989 ( R-HSA-110320 ) R-HSA-5654989 Reaction Name: SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA See in Reactome R-HSA-5688834 ( R-HSA-5689877 ) R-HSA-5688834 Reaction Name: ATXN3 binds VCP See in Reactome R-HSA-6781953 ( R-HSA-5689896 ) R-HSA-6781953 Reaction Name: YOD1 binds VCP See in Reactome R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-8850594 ( R-HSA-532668 ) R-HSA-8850594 Reaction Name: Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins See in Reactome R-HSA-8866542 ( R-HSA-382556 ) R-HSA-8866542 Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol See in Reactome R-HSA-8866546 ( R-HSA-382556 ) R-HSA-8866546 Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR See in Reactome R-HSA-8866551 ( R-HSA-382556 ) R-HSA-8866551 Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation See in Reactome R-HSA-8932276 ( R-HSA-8876725 ) R-HSA-8932276 Reaction Name: VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP See in Reactome R-HSA-8943080 ( R-HSA-8866654 ) R-HSA-8943080 Reaction Name: TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11 See in Reactome R-HSA-8943083 ( R-HSA-8866654 ) R-HSA-8943083 Reaction Name: US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome R-HSA-9646347 ( R-HSA-9646399 ) R-HSA-9646347 Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1 See in Reactome R-HSA-9646354 ( R-HSA-9646399 ) R-HSA-9646354 Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex See in Reactome R-HSA-9755507 () R-HSA-9755507 Reaction Name: UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex See in Reactome R-HSA-9758088 () R-HSA-9758088 Reaction Name: UBXN7 binds VCP hexamer:UBF1:NPLOC4 See in Reactome R-HSA-9758090 () R-HSA-9758090 Reaction Name: Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation See in Reactome
MONDO:0008185	CFTR	P13569	5.6.1.6	R-HSA-9613829 R-HSA-9613829 Reactome Name: Chaperone Mediated Autophagy See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-9615710 R-HSA-9615710 Reactome Name: Late endosomal microautophagy See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-5627083 R-HSA-5627083 Reactome Name: RHO GTPases regulate CFTR trafficking See in Reactome R-HSA-9646399 R-HSA-9646399 Reactome Name: Aggrephagy See in Reactome R-HSA-9013406 R-HSA-9013406 Reactome Name: RHOQ GTPase cycle See in Reactome	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Autophagy Transport of small molecules Metabolism of proteins Signal Transduction Vesicle-mediated transport	R-HSA-1454916 ( R-HSA-382556 ) R-HSA-1454916 Reaction Name: The ABCC family mediates organic anion transport See in Reactome R-HSA-383190 ( R-HSA-382556 ) R-HSA-383190 Reaction Name: HCO3- transport through ion channel See in Reactome R-HSA-5627071 ( R-HSA-5627083 ) R-HSA-5627071 Reaction Name: RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane See in Reactome R-HSA-5627072 ( R-HSA-5627083; R-HSA-9013406 ) R-HSA-5627072 Reaction Name: RHOQ binds GOPC:CFTR See in Reactome R-HSA-5627275 ( R-HSA-5627083 ) R-HSA-5627275 Reaction Name: GOPC promotes translocation of CFTR to lysosomes See in Reactome R-HSA-5678863 ( R-HSA-382556 ) R-HSA-5678863 Reaction Name: CFTR transports Cl- from cytosol to extracellular region See in Reactome R-HSA-6782106 ( R-HSA-5689880 ) R-HSA-6782106 Reaction Name: USP10 deubiquitinates SNX3, CFTR See in Reactome R-HSA-8866277 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866277 Reaction Name: AP-2 directly binds some endocytic cargo See in Reactome R-HSA-8866542 ( R-HSA-382556 ) R-HSA-8866542 Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol See in Reactome R-HSA-8866546 ( R-HSA-382556 ) R-HSA-8866546 Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR See in Reactome R-HSA-8866551 ( R-HSA-382556 ) R-HSA-8866551 Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation See in Reactome R-HSA-8866553 ( R-HSA-382556 ) R-HSA-8866553 Reaction Name: misfolded CFTR is degraded by the 26S proteasome See in Reactome R-HSA-8866851 ( R-HSA-382556 ) R-HSA-8866851 Reaction Name: CFTR transits to the plasma membrane See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-9615721 ( R-HSA-9613829; R-HSA-9615710 ) R-HSA-9615721 Reaction Name: HSPA8 binds substrate See in Reactome R-HSA-9620197 ( R-HSA-9613829 ) R-HSA-9620197 Reaction Name: HSPA8:Substrate binds LAMP2a See in Reactome R-HSA-9622831 ( R-HSA-9613829 ) R-HSA-9622831 Reaction Name: Substrate:LAMP2a binds HSP90 See in Reactome R-HSA-9622840 ( R-HSA-9613829 ) R-HSA-9622840 Reaction Name: HSPA8 dissociates from LAMP2A-bound substrate See in Reactome R-HSA-9624158 ( R-HSA-9613829 ) R-HSA-9624158 Reaction Name: Substrate:LAMP2a:HSP90 polymerizes See in Reactome R-HSA-9625188 ( R-HSA-9613829 ) R-HSA-9625188 Reaction Name: HSPA8 transports unfolded substrate to lysosomal lumen for degradation See in Reactome R-HSA-9625196 ( R-HSA-9613829 ) R-HSA-9625196 Reaction Name: Unfolded substrate in LAMP2a multimeric complex binds HSPA8 See in Reactome R-HSA-9625197 ( R-HSA-9613829 ) R-HSA-9625197 Reaction Name: GFAP binds LAMP2a multimer See in Reactome R-HSA-9626060 ( R-HSA-9613829 ) R-HSA-9626060 Reaction Name: HSPA8:Substrate dissociates from LAMP2a multimer See in Reactome R-HSA-9631065 ( R-HSA-9615710 ) R-HSA-9631065 Reaction Name: Substrate translocates into late endosomal lumen See in Reactome R-HSA-9631068 ( R-HSA-9615710 ) R-HSA-9631068 Reaction Name: HSPA8:substrate binds late endosomal phospholipids See in Reactome R-HSA-9641109 ( R-HSA-9646399 ) R-HSA-9641109 Reaction Name: PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 See in Reactome R-HSA-9641111 ( R-HSA-9646399 ) R-HSA-9641111 Reaction Name: Parkin transfers Ub to misfolded proteins See in Reactome R-HSA-9641127 ( R-HSA-9646399 ) R-HSA-9641127 Reaction Name: Ub:misfolded proteins polymerize to PolyUb:misfolded proteins See in Reactome R-HSA-9646347 ( R-HSA-9646399 ) R-HSA-9646347 Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1 See in Reactome R-HSA-9646348 ( R-HSA-9646399 ) R-HSA-9646348 Reaction Name: PolyUb-Misfolded Proteins:HDAC6 bind dynein motor See in Reactome R-HSA-9646354 ( R-HSA-9646399 ) R-HSA-9646354 Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex See in Reactome R-HSA-9646383 ( R-HSA-9646399 ) R-HSA-9646383 Reaction Name: Dynein motors transport misfolded proteins See in Reactome R-HSA-9646390 ( R-HSA-9646399 ) R-HSA-9646390 Reaction Name: Misfolded proteins:HDAC6:Dynein motor binds microtubule See in Reactome R-HSA-9646679 ( R-HSA-9646399 ) R-HSA-9646679 Reaction Name: PolyUb-Misfolded proteins bind vimentin to form aggresome See in Reactome R-HSA-9646685 ( R-HSA-9646399 ) R-HSA-9646685 Reaction Name: Aggresome dissociates from dynein and microtubule See in Reactome
MONDO:0008333	ABCC6	O95255	7.6.2.3 7.6.2.-	R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome	R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Transport of small molecules	R-HSA-1454916 ( R-HSA-382556 ) R-HSA-1454916 Reaction Name: The ABCC family mediates organic anion transport See in Reactome
MONDO:0008887	CFTR	P13569	5.6.1.6	R-HSA-9613829 R-HSA-9613829 Reactome Name: Chaperone Mediated Autophagy See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-9615710 R-HSA-9615710 Reactome Name: Late endosomal microautophagy See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-5627083 R-HSA-5627083 Reactome Name: RHO GTPases regulate CFTR trafficking See in Reactome R-HSA-9646399 R-HSA-9646399 Reactome Name: Aggrephagy See in Reactome R-HSA-9013406 R-HSA-9013406 Reactome Name: RHOQ GTPase cycle See in Reactome	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Autophagy Transport of small molecules Metabolism of proteins Signal Transduction Vesicle-mediated transport	R-HSA-1454916 ( R-HSA-382556 ) R-HSA-1454916 Reaction Name: The ABCC family mediates organic anion transport See in Reactome R-HSA-383190 ( R-HSA-382556 ) R-HSA-383190 Reaction Name: HCO3- transport through ion channel See in Reactome R-HSA-5627071 ( R-HSA-5627083 ) R-HSA-5627071 Reaction Name: RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane See in Reactome R-HSA-5627072 ( R-HSA-5627083; R-HSA-9013406 ) R-HSA-5627072 Reaction Name: RHOQ binds GOPC:CFTR See in Reactome R-HSA-5627275 ( R-HSA-5627083 ) R-HSA-5627275 Reaction Name: GOPC promotes translocation of CFTR to lysosomes See in Reactome R-HSA-5678863 ( R-HSA-382556 ) R-HSA-5678863 Reaction Name: CFTR transports Cl- from cytosol to extracellular region See in Reactome R-HSA-6782106 ( R-HSA-5689880 ) R-HSA-6782106 Reaction Name: USP10 deubiquitinates SNX3, CFTR See in Reactome R-HSA-8866277 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866277 Reaction Name: AP-2 directly binds some endocytic cargo See in Reactome R-HSA-8866542 ( R-HSA-382556 ) R-HSA-8866542 Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol See in Reactome R-HSA-8866546 ( R-HSA-382556 ) R-HSA-8866546 Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR See in Reactome R-HSA-8866551 ( R-HSA-382556 ) R-HSA-8866551 Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation See in Reactome R-HSA-8866553 ( R-HSA-382556 ) R-HSA-8866553 Reaction Name: misfolded CFTR is degraded by the 26S proteasome See in Reactome R-HSA-8866851 ( R-HSA-382556 ) R-HSA-8866851 Reaction Name: CFTR transits to the plasma membrane See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-9615721 ( R-HSA-9613829; R-HSA-9615710 ) R-HSA-9615721 Reaction Name: HSPA8 binds substrate See in Reactome R-HSA-9620197 ( R-HSA-9613829 ) R-HSA-9620197 Reaction Name: HSPA8:Substrate binds LAMP2a See in Reactome R-HSA-9622831 ( R-HSA-9613829 ) R-HSA-9622831 Reaction Name: Substrate:LAMP2a binds HSP90 See in Reactome R-HSA-9622840 ( R-HSA-9613829 ) R-HSA-9622840 Reaction Name: HSPA8 dissociates from LAMP2A-bound substrate See in Reactome R-HSA-9624158 ( R-HSA-9613829 ) R-HSA-9624158 Reaction Name: Substrate:LAMP2a:HSP90 polymerizes See in Reactome R-HSA-9625188 ( R-HSA-9613829 ) R-HSA-9625188 Reaction Name: HSPA8 transports unfolded substrate to lysosomal lumen for degradation See in Reactome R-HSA-9625196 ( R-HSA-9613829 ) R-HSA-9625196 Reaction Name: Unfolded substrate in LAMP2a multimeric complex binds HSPA8 See in Reactome R-HSA-9625197 ( R-HSA-9613829 ) R-HSA-9625197 Reaction Name: GFAP binds LAMP2a multimer See in Reactome R-HSA-9626060 ( R-HSA-9613829 ) R-HSA-9626060 Reaction Name: HSPA8:Substrate dissociates from LAMP2a multimer See in Reactome R-HSA-9631065 ( R-HSA-9615710 ) R-HSA-9631065 Reaction Name: Substrate translocates into late endosomal lumen See in Reactome R-HSA-9631068 ( R-HSA-9615710 ) R-HSA-9631068 Reaction Name: HSPA8:substrate binds late endosomal phospholipids See in Reactome R-HSA-9641109 ( R-HSA-9646399 ) R-HSA-9641109 Reaction Name: PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 See in Reactome R-HSA-9641111 ( R-HSA-9646399 ) R-HSA-9641111 Reaction Name: Parkin transfers Ub to misfolded proteins See in Reactome R-HSA-9641127 ( R-HSA-9646399 ) R-HSA-9641127 Reaction Name: Ub:misfolded proteins polymerize to PolyUb:misfolded proteins See in Reactome R-HSA-9646347 ( R-HSA-9646399 ) R-HSA-9646347 Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1 See in Reactome R-HSA-9646348 ( R-HSA-9646399 ) R-HSA-9646348 Reaction Name: PolyUb-Misfolded Proteins:HDAC6 bind dynein motor See in Reactome R-HSA-9646354 ( R-HSA-9646399 ) R-HSA-9646354 Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex See in Reactome R-HSA-9646383 ( R-HSA-9646399 ) R-HSA-9646383 Reaction Name: Dynein motors transport misfolded proteins See in Reactome R-HSA-9646390 ( R-HSA-9646399 ) R-HSA-9646390 Reaction Name: Misfolded proteins:HDAC6:Dynein motor binds microtubule See in Reactome R-HSA-9646679 ( R-HSA-9646399 ) R-HSA-9646679 Reaction Name: PolyUb-Misfolded proteins bind vimentin to form aggresome See in Reactome R-HSA-9646685 ( R-HSA-9646399 ) R-HSA-9646685 Reaction Name: Aggresome dissociates from dynein and microtubule See in Reactome
MONDO:0009061	CFTR	P13569	5.6.1.6	R-HSA-9613829 R-HSA-9613829 Reactome Name: Chaperone Mediated Autophagy See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-9615710 R-HSA-9615710 Reactome Name: Late endosomal microautophagy See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-5627083 R-HSA-5627083 Reactome Name: RHO GTPases regulate CFTR trafficking See in Reactome R-HSA-9646399 R-HSA-9646399 Reactome Name: Aggrephagy See in Reactome R-HSA-9013406 R-HSA-9013406 Reactome Name: RHOQ GTPase cycle See in Reactome	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9663891 R-HSA-9663891 Reactome Name: Selective autophagy See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Autophagy Transport of small molecules Metabolism of proteins Signal Transduction Vesicle-mediated transport	R-HSA-1454916 ( R-HSA-382556 ) R-HSA-1454916 Reaction Name: The ABCC family mediates organic anion transport See in Reactome R-HSA-383190 ( R-HSA-382556 ) R-HSA-383190 Reaction Name: HCO3- transport through ion channel See in Reactome R-HSA-5627071 ( R-HSA-5627083 ) R-HSA-5627071 Reaction Name: RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane See in Reactome R-HSA-5627072 ( R-HSA-5627083; R-HSA-9013406 ) R-HSA-5627072 Reaction Name: RHOQ binds GOPC:CFTR See in Reactome R-HSA-5627275 ( R-HSA-5627083 ) R-HSA-5627275 Reaction Name: GOPC promotes translocation of CFTR to lysosomes See in Reactome R-HSA-5678863 ( R-HSA-382556 ) R-HSA-5678863 Reaction Name: CFTR transports Cl- from cytosol to extracellular region See in Reactome R-HSA-6782106 ( R-HSA-5689880 ) R-HSA-6782106 Reaction Name: USP10 deubiquitinates SNX3, CFTR See in Reactome R-HSA-8866277 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866277 Reaction Name: AP-2 directly binds some endocytic cargo See in Reactome R-HSA-8866542 ( R-HSA-382556 ) R-HSA-8866542 Reaction Name: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol See in Reactome R-HSA-8866546 ( R-HSA-382556 ) R-HSA-8866546 Reaction Name: RNF5 and RNF185 ubiquitinate misfolded CFTR See in Reactome R-HSA-8866551 ( R-HSA-382556 ) R-HSA-8866551 Reaction Name: CFTR binds components of the ERAD machinery for ubiquitination and degradation See in Reactome R-HSA-8866553 ( R-HSA-382556 ) R-HSA-8866553 Reaction Name: misfolded CFTR is degraded by the 26S proteasome See in Reactome R-HSA-8866851 ( R-HSA-382556 ) R-HSA-8866851 Reaction Name: CFTR transits to the plasma membrane See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-9615721 ( R-HSA-9613829; R-HSA-9615710 ) R-HSA-9615721 Reaction Name: HSPA8 binds substrate See in Reactome R-HSA-9620197 ( R-HSA-9613829 ) R-HSA-9620197 Reaction Name: HSPA8:Substrate binds LAMP2a See in Reactome R-HSA-9622831 ( R-HSA-9613829 ) R-HSA-9622831 Reaction Name: Substrate:LAMP2a binds HSP90 See in Reactome R-HSA-9622840 ( R-HSA-9613829 ) R-HSA-9622840 Reaction Name: HSPA8 dissociates from LAMP2A-bound substrate See in Reactome R-HSA-9624158 ( R-HSA-9613829 ) R-HSA-9624158 Reaction Name: Substrate:LAMP2a:HSP90 polymerizes See in Reactome R-HSA-9625188 ( R-HSA-9613829 ) R-HSA-9625188 Reaction Name: HSPA8 transports unfolded substrate to lysosomal lumen for degradation See in Reactome R-HSA-9625196 ( R-HSA-9613829 ) R-HSA-9625196 Reaction Name: Unfolded substrate in LAMP2a multimeric complex binds HSPA8 See in Reactome R-HSA-9625197 ( R-HSA-9613829 ) R-HSA-9625197 Reaction Name: GFAP binds LAMP2a multimer See in Reactome R-HSA-9626060 ( R-HSA-9613829 ) R-HSA-9626060 Reaction Name: HSPA8:Substrate dissociates from LAMP2a multimer See in Reactome R-HSA-9631065 ( R-HSA-9615710 ) R-HSA-9631065 Reaction Name: Substrate translocates into late endosomal lumen See in Reactome R-HSA-9631068 ( R-HSA-9615710 ) R-HSA-9631068 Reaction Name: HSPA8:substrate binds late endosomal phospholipids See in Reactome R-HSA-9641109 ( R-HSA-9646399 ) R-HSA-9641109 Reaction Name: PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 See in Reactome R-HSA-9641111 ( R-HSA-9646399 ) R-HSA-9641111 Reaction Name: Parkin transfers Ub to misfolded proteins See in Reactome R-HSA-9641127 ( R-HSA-9646399 ) R-HSA-9641127 Reaction Name: Ub:misfolded proteins polymerize to PolyUb:misfolded proteins See in Reactome R-HSA-9646347 ( R-HSA-9646399 ) R-HSA-9646347 Reaction Name: PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1 See in Reactome R-HSA-9646348 ( R-HSA-9646399 ) R-HSA-9646348 Reaction Name: PolyUb-Misfolded Proteins:HDAC6 bind dynein motor See in Reactome R-HSA-9646354 ( R-HSA-9646399 ) R-HSA-9646354 Reaction Name: PolyUb-Misfolded Proteins:HDAC6 dissociate from complex See in Reactome R-HSA-9646383 ( R-HSA-9646399 ) R-HSA-9646383 Reaction Name: Dynein motors transport misfolded proteins See in Reactome R-HSA-9646390 ( R-HSA-9646399 ) R-HSA-9646390 Reaction Name: Misfolded proteins:HDAC6:Dynein motor binds microtubule See in Reactome R-HSA-9646679 ( R-HSA-9646399 ) R-HSA-9646679 Reaction Name: PolyUb-Misfolded proteins bind vimentin to form aggresome See in Reactome R-HSA-9646685 ( R-HSA-9646399 ) R-HSA-9646685 Reaction Name: Aggresome dissociates from dynein and microtubule See in Reactome
MONDO:0009380	ABCC2	Q92887	7.6.2.2 7.6.2.3 7.6.2.-	R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-189483 R-HSA-189483 Reactome Name: Heme degradation See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome	Metabolism Transport of small molecules	R-HSA-1454916 ( R-HSA-382556 ) R-HSA-1454916 Reaction Name: The ABCC family mediates organic anion transport See in Reactome R-HSA-5679041 ( R-HSA-189483 ) R-HSA-5679041 Reaction Name: ABCC2 transports BMG,BDG from cytosol to extracellular region See in Reactome
MONDO:0009549	ABCA4	P78363	7.6.2.1	R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-2453902 R-HSA-2453902 Reactome Name: The canonical retinoid cycle in rods (twilight vision) See in Reactome	R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Sensory Perception Transport of small molecules	R-HSA-1467466 ( R-HSA-2453902; R-HSA-382556 ) R-HSA-1467466 Reaction Name: ABCA4 mediates atRAL transport See in Reactome R-HSA-2466749 ( R-HSA-2453902 ) R-HSA-2466749 Reaction Name: ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol See in Reactome
MONDO:0009559	ABCA4	P78363	7.6.2.1	R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-2453902 R-HSA-2453902 Reactome Name: The canonical retinoid cycle in rods (twilight vision) See in Reactome	R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Sensory Perception Transport of small molecules	R-HSA-1467466 ( R-HSA-2453902; R-HSA-382556 ) R-HSA-1467466 Reaction Name: ABCA4 mediates atRAL transport See in Reactome R-HSA-2466749 ( R-HSA-2453902 ) R-HSA-2466749 Reaction Name: ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol See in Reactome

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