DAR - Bologna Biocomputing Group

Search results (Reactome ID: R-HSA-381426)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007204	P4HB	P07237	5.3.4.1	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-8963888 R-HSA-8963888 Reactome Name: Chylomicron assembly See in Reactome R-HSA-8964041 R-HSA-8964041 Reactome Name: LDL remodeling See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-8866423 R-HSA-8866423 Reactome Name: VLDL assembly See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome	R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8963898 R-HSA-8963898 Reactome Name: Plasma lipoprotein assembly See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome	Cellular responses to stimuli Immune System Transport of small molecules Extracellular matrix organization Metabolism of proteins Signal Transduction	R-HSA-1650808 ( R-HSA-1650814 ) R-HSA-1650808 Reaction Name: Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines See in Reactome R-HSA-174741 ( R-HSA-8963888 ) R-HSA-174741 Reaction Name: ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron See in Reactome R-HSA-174786 ( R-HSA-8963888 ) R-HSA-174786 Reaction Name: ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex See in Reactome R-HSA-2002460 ( R-HSA-1650814 ) R-HSA-2002460 Reaction Name: P4HB binds Collagen chains See in Reactome R-HSA-3341296 ( R-HSA-3299685 ) R-HSA-3341296 Reaction Name: GPX7,8 catalyze peroxidation of P4HB (PDI) See in Reactome R-HSA-5358336 ( R-HSA-5358346 ) R-HSA-5358336 Reaction Name: P4HB forms mixed disulphides with Hh precursors See in Reactome R-HSA-5358340 ( R-HSA-5358346 ) R-HSA-5358340 Reaction Name: Autoproteolytic cleavage of Hh precursors See in Reactome R-HSA-8866329 ( R-HSA-8866423 ) R-HSA-8866329 Reaction Name: MTTP lipidates APOB-100, forming a pre-VLDL See in Reactome R-HSA-8948234 ( R-HSA-1650814 ) R-HSA-8948234 Reaction Name: P4HB:4-Hyp collagen propeptides dissociates See in Reactome R-HSA-8950113 ( R-HSA-9020591 ) R-HSA-8950113 Reaction Name: IL12A binds IL12B See in Reactome R-HSA-8950183 ( R-HSA-9020933 ) R-HSA-8950183 Reaction Name: IL12B binds IL23A See in Reactome R-HSA-8950456 ( R-HSA-9020591 ) R-HSA-8950456 Reaction Name: IL12B dimerizes See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome R-HSA-9737780 ( R-HSA-8964041 ) R-HSA-9737780 Reaction Name: MTTP binds lomitapide See in Reactome
MONDO:0007750	PCSK9	Q8NBP7	3.4.21.-	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome R-HSA-8866427 R-HSA-8866427 Reactome Name: VLDLR internalisation and degradation See in Reactome R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Transport of small molecules Metabolism of proteins	R-HSA-6784729 ( R-HSA-8964038 ) R-HSA-6784729 Reaction Name: PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome See in Reactome R-HSA-6784734 ( R-HSA-8964038 ) R-HSA-6784734 Reaction Name: PCSK9 binds LDLR See in Reactome R-HSA-6784735 ( R-HSA-8964038 ) R-HSA-6784735 Reaction Name: PCSK9:LDLR bind to Clathrin See in Reactome R-HSA-6784738 ( R-HSA-8964038 ) R-HSA-6784738 Reaction Name: Degradation of PCSK9:LDLR:Clathrin-coated vesicle See in Reactome R-HSA-8855111 ( R-HSA-8866427 ) R-HSA-8855111 Reaction Name: VLDLR binds PCSK9 See in Reactome R-HSA-8855130 ( R-HSA-8866427 ) R-HSA-8855130 Reaction Name: VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane See in Reactome R-HSA-8855131 ( R-HSA-8866427 ) R-HSA-8855131 Reaction Name: VLDLR:PCSK9 binds Clathrin-coated vesicles See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome
MONDO:0008146	P4HB	P07237	5.3.4.1	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-8963888 R-HSA-8963888 Reactome Name: Chylomicron assembly See in Reactome R-HSA-8964041 R-HSA-8964041 Reactome Name: LDL remodeling See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-8866423 R-HSA-8866423 Reactome Name: VLDL assembly See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome	R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8963898 R-HSA-8963898 Reactome Name: Plasma lipoprotein assembly See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome	Cellular responses to stimuli Immune System Transport of small molecules Extracellular matrix organization Metabolism of proteins Signal Transduction	R-HSA-1650808 ( R-HSA-1650814 ) R-HSA-1650808 Reaction Name: Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines See in Reactome R-HSA-174741 ( R-HSA-8963888 ) R-HSA-174741 Reaction Name: ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron See in Reactome R-HSA-174786 ( R-HSA-8963888 ) R-HSA-174786 Reaction Name: ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex See in Reactome R-HSA-2002460 ( R-HSA-1650814 ) R-HSA-2002460 Reaction Name: P4HB binds Collagen chains See in Reactome R-HSA-3341296 ( R-HSA-3299685 ) R-HSA-3341296 Reaction Name: GPX7,8 catalyze peroxidation of P4HB (PDI) See in Reactome R-HSA-5358336 ( R-HSA-5358346 ) R-HSA-5358336 Reaction Name: P4HB forms mixed disulphides with Hh precursors See in Reactome R-HSA-5358340 ( R-HSA-5358346 ) R-HSA-5358340 Reaction Name: Autoproteolytic cleavage of Hh precursors See in Reactome R-HSA-8866329 ( R-HSA-8866423 ) R-HSA-8866329 Reaction Name: MTTP lipidates APOB-100, forming a pre-VLDL See in Reactome R-HSA-8948234 ( R-HSA-1650814 ) R-HSA-8948234 Reaction Name: P4HB:4-Hyp collagen propeptides dissociates See in Reactome R-HSA-8950113 ( R-HSA-9020591 ) R-HSA-8950113 Reaction Name: IL12A binds IL12B See in Reactome R-HSA-8950183 ( R-HSA-9020933 ) R-HSA-8950183 Reaction Name: IL12B binds IL23A See in Reactome R-HSA-8950456 ( R-HSA-9020591 ) R-HSA-8950456 Reaction Name: IL12B dimerizes See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome R-HSA-9737780 ( R-HSA-8964041 ) R-HSA-9737780 Reaction Name: MTTP binds lomitapide See in Reactome
MONDO:0008316	PROC	P04070	3.4.21.69	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-140875 R-HSA-140875 Reactome Name: Common Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Metabolism of proteins Hemostasis	R-HSA-140599 ( R-HSA-140875 ) R-HSA-140599 Reaction Name: factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides See in Reactome R-HSA-140696 ( R-HSA-140875 ) R-HSA-140696 Reaction Name: factor V -> factor Va + factor V activation peptide See in Reactome R-HSA-140840 ( R-HSA-140875 ) R-HSA-140840 Reaction Name: fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B See in Reactome R-HSA-141026 ( R-HSA-140875 ) R-HSA-141026 Reaction Name: Activated protein C cleaves factor Va to factor Vi intermediate form See in Reactome R-HSA-141040 ( R-HSA-140875; R-HSA-202733 ) R-HSA-141040 Reaction Name: Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C See in Reactome R-HSA-158137 ( R-HSA-140837 ) R-HSA-158137 Reaction Name: factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer See in Reactome R-HSA-158419 ( R-HSA-140837 ) R-HSA-158419 Reaction Name: factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) See in Reactome R-HSA-159762 ( R-HSA-159763 ) R-HSA-159762 Reaction Name: Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-159771 ( R-HSA-159782 ) R-HSA-159771 Reaction Name: Furin cleaves pro-protein C to protein C See in Reactome R-HSA-159795 ( R-HSA-159740 ) R-HSA-159795 Reaction Name: GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) See in Reactome R-HSA-5591040 ( R-HSA-140875 ) R-HSA-5591040 Reaction Name: Activated protein C cleaves Factor Va intermediate form for Factor Va See in Reactome R-HSA-5591052 ( R-HSA-140875 ) R-HSA-5591052 Reaction Name: PROCR binds Protein C See in Reactome R-HSA-5591086 ( R-HSA-140875 ) R-HSA-5591086 Reaction Name: SERPINA5 binds activated protein C See in Reactome R-HSA-5603467 ( R-HSA-140875 ) R-HSA-5603467 Reaction Name: Activated protein C is released from PROCR See in Reactome R-HSA-5604929 ( R-HSA-140875 ) R-HSA-5604929 Reaction Name: Activated protein C binds Protein S See in Reactome R-HSA-5606996 ( R-HSA-140875 ) R-HSA-5606996 Reaction Name: Soluble PROCR binds activated protein C See in Reactome R-HSA-5607002 ( R-HSA-140875 ) R-HSA-5607002 Reaction Name: Activated protein C cleaves factor VIIIa See in Reactome R-HSA-5607058 ( R-HSA-140875 ) R-HSA-5607058 Reaction Name: Activated protein C:PROCR binds F2R See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome
MONDO:0008559	F2	P00734	3.4.21.5	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-375276 R-HSA-375276 Reactome Name: Peptide ligand-binding receptors See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-140875 R-HSA-140875 Reactome Name: Common Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome	R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-500792 R-HSA-500792 Reactome Name: GPCR ligand binding See in Reactome R-HSA-373076 R-HSA-373076 Reactome Name: Class A/1 (Rhodopsin-like receptors) See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114697 ( R-HSA-456926 ) R-HSA-114697 Reaction Name: Activated thrombin (factor IIa) cleaves PAR3,4, activating them See in Reactome R-HSA-140599 ( R-HSA-140875 ) R-HSA-140599 Reaction Name: factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides See in Reactome R-HSA-140664 ( R-HSA-140875 ) R-HSA-140664 Reaction Name: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) See in Reactome R-HSA-140696 ( R-HSA-140875 ) R-HSA-140696 Reaction Name: factor V -> factor Va + factor V activation peptide See in Reactome R-HSA-140700 ( R-HSA-140875 ) R-HSA-140700 Reaction Name: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) See in Reactome R-HSA-140791 ( R-HSA-140875 ) R-HSA-140791 Reaction Name: activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin See in Reactome R-HSA-140840 ( R-HSA-140875 ) R-HSA-140840 Reaction Name: fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B See in Reactome R-HSA-140870 ( R-HSA-140875 ) R-HSA-140870 Reaction Name: thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin See in Reactome R-HSA-140872 ( R-HSA-140875 ) R-HSA-140872 Reaction Name: thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators See in Reactome R-HSA-141040 ( R-HSA-140875; R-HSA-202733 ) R-HSA-141040 Reaction Name: Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C See in Reactome R-HSA-141046 ( R-HSA-140875 ) R-HSA-141046 Reaction Name: activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin See in Reactome R-HSA-158137 ( R-HSA-140837 ) R-HSA-158137 Reaction Name: factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer See in Reactome R-HSA-158419 ( R-HSA-140837 ) R-HSA-158419 Reaction Name: factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) See in Reactome R-HSA-159728 ( R-HSA-159782 ) R-HSA-159728 Reaction Name: Furin cleaves pro-prothrombin to prothrombin See in Reactome R-HSA-159826 ( R-HSA-159740 ) R-HSA-159826 Reaction Name: GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) See in Reactome R-HSA-159843 ( R-HSA-159763 ) R-HSA-159843 Reaction Name: Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-379048 ( R-HSA-416476 ) R-HSA-379048 Reaction Name: Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 See in Reactome R-HSA-381446 ( R-HSA-381426 ) R-HSA-381446 Reaction Name: Thrombin proteolyzes IGF:IGFBP3:ALS See in Reactome R-HSA-389463 ( R-HSA-375276 ) R-HSA-389463 Reaction Name: Proteinase-activated receptors can bind thrombin See in Reactome R-HSA-429529 ( R-HSA-76009 ) R-HSA-429529 Reaction Name: Thrombin binding to GP1b:IX:V See in Reactome R-HSA-5578883 ( R-HSA-140875 ) R-HSA-5578883 Reaction Name: Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) See in Reactome R-HSA-5602080 ( R-HSA-140875 ) R-HSA-5602080 Reaction Name: Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. See in Reactome R-HSA-749448 ( R-HSA-416476 ) R-HSA-749448 Reaction Name: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq See in Reactome R-HSA-749452 ( R-HSA-416476 ) R-HSA-749452 Reaction Name: The Ligand:GPCR:Gq complex dissociates See in Reactome R-HSA-8852716 ( R-HSA-977606 ) R-HSA-8852716 Reaction Name: Thrombin, ELANE cleave C5 See in Reactome R-HSA-9015379 ( R-HSA-140837 ) R-HSA-9015379 Reaction Name: Factor IIa inhibitors (compounds) binds IIa See in Reactome R-HSA-9603302 ( R-HSA-140837 ) R-HSA-9603302 Reaction Name: Factor IIa inhibitors (peptide) binds IIa See in Reactome R-HSA-9708859 ( R-HSA-456926 ) R-HSA-9708859 Reaction Name: Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it See in Reactome
MONDO:0009009	PLG	P00747	3.4.21.7	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-75205 R-HSA-75205 Reactome Name: Dissolution of Fibrin Clot See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome	R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Extracellular matrix organization Hemostasis Signal Transduction	R-HSA-1454843 ( R-HSA-1474228 ) R-HSA-1454843 Reaction Name: E-cadherin degradation by MMP3, MMP7 and plasmin. See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-158721 ( R-HSA-75205 ) R-HSA-158721 Reaction Name: histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen See in Reactome R-HSA-158722 ( R-HSA-75205 ) R-HSA-158722 Reaction Name: histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen See in Reactome R-HSA-158744 ( R-HSA-75205 ) R-HSA-158744 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin See in Reactome R-HSA-158747 ( R-HSA-75205 ) R-HSA-158747 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) See in Reactome R-HSA-158750 ( R-HSA-75205 ) R-HSA-158750 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin See in Reactome R-HSA-158756 ( R-HSA-75205 ) R-HSA-158756 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen See in Reactome R-HSA-158766 ( R-HSA-75205 ) R-HSA-158766 Reaction Name: fibrin multimer, crosslinked -> fibrin digestion products (plasmin) See in Reactome R-HSA-158784 ( R-HSA-75205 ) R-HSA-158784 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen See in Reactome R-HSA-158893 ( R-HSA-75205 ) R-HSA-158893 Reaction Name: alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin See in Reactome R-HSA-158925 ( R-HSA-75205 ) R-HSA-158925 Reaction Name: plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) See in Reactome R-HSA-158941 ( R-HSA-75205 ) R-HSA-158941 Reaction Name: plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein See in Reactome R-HSA-158942 ( R-HSA-75205 ) R-HSA-158942 Reaction Name: urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR See in Reactome R-HSA-158982 ( R-HSA-75205 ) R-HSA-158982 Reaction Name: plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) See in Reactome R-HSA-1592314 ( R-HSA-1474228 ) R-HSA-1592314 Reaction Name: HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) See in Reactome R-HSA-1592316 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592316 Reaction Name: Initial activation of proMMP1 See in Reactome R-HSA-1592371 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592371 Reaction Name: Initial activation of proMMP3 See in Reactome R-HSA-1592398 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592398 Reaction Name: Activation of proMMP8 See in Reactome R-HSA-1602458 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602458 Reaction Name: Activation of proMMP10 See in Reactome R-HSA-1602488 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602488 Reaction Name: Initial activation of proMMP13 by plasmin and trypsin See in Reactome R-HSA-1604712 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604712 Reaction Name: Initial activation of proMMP7 by trypsin See in Reactome R-HSA-381461 ( R-HSA-381426 ) R-HSA-381461 Reaction Name: Plasmin proteolyzes IGF:IGFBP-3:ALS See in Reactome R-HSA-382061 ( R-HSA-186797 ) R-HSA-382061 Reaction Name: Extracellular processing of novel PDGFs See in Reactome R-HSA-481007 ( R-HSA-114608 ) R-HSA-481007 Reaction Name: Exocytosis of platelet alpha granule contents See in Reactome
MONDO:0009809	MMP2	P08253	3.4.24.24	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Metabolism of proteins Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1454757 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454757 Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 See in Reactome R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1454791 ( R-HSA-1474228 ) R-HSA-1454791 Reaction Name: MMP2, MMP7, MMP9 bind CD44 See in Reactome R-HSA-1454822 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454822 Reaction Name: Collagen type I degradation by MMP1,2,8,13, PRSS2 See in Reactome R-HSA-1564112 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564112 Reaction Name: Collagen type VI degradation by MMP2,9,11 See in Reactome R-HSA-1564120 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564120 Reaction Name: Collagen type VII degradation by MMP1,2,3 See in Reactome R-HSA-1564142 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564142 Reaction Name: Collagen type IV degradation by MMP2,3,4,9,10,12 See in Reactome R-HSA-1564143 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564143 Reaction Name: Collagen type X degradation by MMP1,2 See in Reactome R-HSA-1564164 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564164 Reaction Name: Collagen type V degradation by MMP2,9,10 See in Reactome R-HSA-1564179 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564179 Reaction Name: Collagen type XI degradation by MMP1,2,3,9 See in Reactome R-HSA-1566962 ( R-HSA-1474228 ) R-HSA-1566962 Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-1592278 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592278 Reaction Name: Autocatalytic activation of proMMP2 See in Reactome R-HSA-1592297 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592297 Reaction Name: Full activation of MMP1 See in Reactome R-HSA-1592436 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592436 Reaction Name: Initial activation of proMMP9 by MMPs See in Reactome R-HSA-1604350 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604350 Reaction Name: MMP14:TIMP2 binds proMMP2 See in Reactome R-HSA-1604359 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604359 Reaction Name: Initial activation of proMMP2 by MMP1, 7 See in Reactome R-HSA-1604360 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604360 Reaction Name: Initial activation of proMMP2 by MMP14 See in Reactome R-HSA-1604368 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604368 Reaction Name: Autocatalytic activation of bound proMMP2 See in Reactome R-HSA-1604690 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604690 Reaction Name: Activation of MMP9 intermediate form by MMPs See in Reactome R-HSA-2485148 ( R-HSA-1474228 ) R-HSA-2485148 Reaction Name: Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 See in Reactome R-HSA-2534248 ( R-HSA-1474228 ) R-HSA-2534248 Reaction Name: DCN (decorin) degradation by MMP2, MMP3, MMP7 See in Reactome R-HSA-3791149 ( R-HSA-1474228 ) R-HSA-3791149 Reaction Name: Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 See in Reactome R-HSA-3791295 ( R-HSA-1474228 ) R-HSA-3791295 Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13 See in Reactome R-HSA-381435 ( R-HSA-381426 ) R-HSA-381435 Reaction Name: Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS See in Reactome R-HSA-3928657 ( R-HSA-3928665 ) R-HSA-3928657 Reaction Name: MMP2,9 cleave EPHB See in Reactome R-HSA-6789615 ( R-HSA-6785807 ) R-HSA-6789615 Reaction Name: Expression of STAT3-upregulated extracellular proteins See in Reactome R-HSA-8940554 ( R-HSA-1474228 ) R-HSA-8940554 Reaction Name: MMP2 cleaves OPTC See in Reactome R-HSA-8943959 ( R-HSA-1474228 ) R-HSA-8943959 Reaction Name: MMP2, MMP9 cleave SCUBE3 See in Reactome R-HSA-9624272 ( R-HSA-9009391 ) R-HSA-9624272 Reaction Name: MMPs cleave HB-EGF See in Reactome
MONDO:0009821	FAM20C	Q8IXL6	2.7.11.1	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Metabolism of proteins	R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome
MONDO:0011369	PCSK9	Q8NBP7	3.4.21.-	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome R-HSA-8866427 R-HSA-8866427 Reactome Name: VLDLR internalisation and degradation See in Reactome R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Transport of small molecules Metabolism of proteins	R-HSA-6784729 ( R-HSA-8964038 ) R-HSA-6784729 Reaction Name: PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome See in Reactome R-HSA-6784734 ( R-HSA-8964038 ) R-HSA-6784734 Reaction Name: PCSK9 binds LDLR See in Reactome R-HSA-6784735 ( R-HSA-8964038 ) R-HSA-6784735 Reaction Name: PCSK9:LDLR bind to Clathrin See in Reactome R-HSA-6784738 ( R-HSA-8964038 ) R-HSA-6784738 Reaction Name: Degradation of PCSK9:LDLR:Clathrin-coated vesicle See in Reactome R-HSA-8855111 ( R-HSA-8866427 ) R-HSA-8855111 Reaction Name: VLDLR binds PCSK9 See in Reactome R-HSA-8855130 ( R-HSA-8866427 ) R-HSA-8855130 Reaction Name: VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane See in Reactome R-HSA-8855131 ( R-HSA-8866427 ) R-HSA-8855131 Reaction Name: VLDLR:PCSK9 binds Clathrin-coated vesicles See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome
MONDO:0011426	CP	P00450	1.16.3.1	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-425410 R-HSA-425410 Reactome Name: Metal ion SLC transporters See in Reactome R-HSA-917937 R-HSA-917937 Reactome Name: Iron uptake and transport See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome	R-HSA-425407 R-HSA-425407 Reactome Name: SLC-mediated transmembrane transport See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-425366 R-HSA-425366 Reactome Name: Transport of bile salts and organic acids, metal ions and amine compounds See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Metabolism of proteins Transport of small molecules	R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome R-HSA-904830 ( R-HSA-425410; R-HSA-917937 ) R-HSA-904830 Reaction Name: SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region See in Reactome R-HSA-917891 ( R-HSA-917937 ) R-HSA-917891 Reaction Name: SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ See in Reactome
MONDO:0011751	MMP1	P03956	3.4.24.7	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-210991 R-HSA-210991 Reactome Name: Basigin interactions See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Immune System Metabolism of proteins Extracellular matrix organization Hemostasis	R-HSA-1454757 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454757 Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 See in Reactome R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1454822 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454822 Reaction Name: Collagen type I degradation by MMP1,2,8,13, PRSS2 See in Reactome R-HSA-1474197 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474197 Reaction Name: Collagen type II degradation by MMP1,3,8,13,PRSS2 See in Reactome R-HSA-1474213 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474213 Reaction Name: Collagen type III degradation by MMP1,8,9,13 See in Reactome R-HSA-1564120 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564120 Reaction Name: Collagen type VII degradation by MMP1,2,3 See in Reactome R-HSA-1564143 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564143 Reaction Name: Collagen type X degradation by MMP1,2 See in Reactome R-HSA-1564169 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564169 Reaction Name: Collagen type VIII degradation by MMP1 See in Reactome R-HSA-1564179 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564179 Reaction Name: Collagen type XI degradation by MMP1,2,3,9 See in Reactome R-HSA-1566981 ( R-HSA-1474228 ) R-HSA-1566981 Reaction Name: Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS See in Reactome R-HSA-1592270 ( R-HSA-1474228 ) R-HSA-1592270 Reaction Name: NID1 degradation by MMP1, 9, 12, ELANE See in Reactome R-HSA-1592297 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592297 Reaction Name: Full activation of MMP1 See in Reactome R-HSA-1592316 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592316 Reaction Name: Initial activation of proMMP1 See in Reactome R-HSA-1592436 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592436 Reaction Name: Initial activation of proMMP9 by MMPs See in Reactome R-HSA-1602473 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602473 Reaction Name: Autocatalytic activation of MMP1 See in Reactome R-HSA-1604359 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604359 Reaction Name: Initial activation of proMMP2 by MMP1, 7 See in Reactome R-HSA-1604690 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604690 Reaction Name: Activation of MMP9 intermediate form by MMPs See in Reactome R-HSA-375135 ( R-HSA-1474228; R-HSA-210991 ) R-HSA-375135 Reaction Name: Basigin binds Matrix metalloproteinase-1 See in Reactome R-HSA-3791149 ( R-HSA-1474228 ) R-HSA-3791149 Reaction Name: Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 See in Reactome R-HSA-3791295 ( R-HSA-1474228 ) R-HSA-3791295 Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13 See in Reactome R-HSA-381435 ( R-HSA-381426 ) R-HSA-381435 Reaction Name: Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS See in Reactome R-HSA-6789615 ( R-HSA-6785807 ) R-HSA-6789615 Reaction Name: Expression of STAT3-upregulated extracellular proteins See in Reactome
MONDO:0012545	PNPLA2	Q96AD5	3.1.1.3	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-1482883 R-HSA-1482883 Reactome Name: Acyl chain remodeling of DAG and TAG See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome	R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483206 R-HSA-1483206 Reactome Name: Glycerophospholipid biosynthesis See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Metabolism of proteins Metabolism	R-HSA-1482647 ( R-HSA-1482883 ) R-HSA-1482647 Reaction Name: 2-MAG and DAG are transacylated to TAG by PNPLA2/3 See in Reactome R-HSA-1482654 ( R-HSA-1482883 ) R-HSA-1482654 Reaction Name: 2-MAG is transacylated to DAG by PNPLA2/3 See in Reactome R-HSA-1482777 ( R-HSA-1482883 ) R-HSA-1482777 Reaction Name: TAG is hydrolyzed to DAG by PNPLA2/3 See in Reactome R-HSA-1482811 ( R-HSA-1482883 ) R-HSA-1482811 Reaction Name: DAG is hydrolyzed to 2-MAG by PNPLA2/3 See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome
MONDO:0012860	PROC	P04070	3.4.21.69	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-140875 R-HSA-140875 Reactome Name: Common Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Metabolism of proteins Hemostasis	R-HSA-140599 ( R-HSA-140875 ) R-HSA-140599 Reaction Name: factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides See in Reactome R-HSA-140696 ( R-HSA-140875 ) R-HSA-140696 Reaction Name: factor V -> factor Va + factor V activation peptide See in Reactome R-HSA-140840 ( R-HSA-140875 ) R-HSA-140840 Reaction Name: fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B See in Reactome R-HSA-141026 ( R-HSA-140875 ) R-HSA-141026 Reaction Name: Activated protein C cleaves factor Va to factor Vi intermediate form See in Reactome R-HSA-141040 ( R-HSA-140875; R-HSA-202733 ) R-HSA-141040 Reaction Name: Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C See in Reactome R-HSA-158137 ( R-HSA-140837 ) R-HSA-158137 Reaction Name: factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer See in Reactome R-HSA-158419 ( R-HSA-140837 ) R-HSA-158419 Reaction Name: factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) See in Reactome R-HSA-159762 ( R-HSA-159763 ) R-HSA-159762 Reaction Name: Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-159771 ( R-HSA-159782 ) R-HSA-159771 Reaction Name: Furin cleaves pro-protein C to protein C See in Reactome R-HSA-159795 ( R-HSA-159740 ) R-HSA-159795 Reaction Name: GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) See in Reactome R-HSA-5591040 ( R-HSA-140875 ) R-HSA-5591040 Reaction Name: Activated protein C cleaves Factor Va intermediate form for Factor Va See in Reactome R-HSA-5591052 ( R-HSA-140875 ) R-HSA-5591052 Reaction Name: PROCR binds Protein C See in Reactome R-HSA-5591086 ( R-HSA-140875 ) R-HSA-5591086 Reaction Name: SERPINA5 binds activated protein C See in Reactome R-HSA-5603467 ( R-HSA-140875 ) R-HSA-5603467 Reaction Name: Activated protein C is released from PROCR See in Reactome R-HSA-5604929 ( R-HSA-140875 ) R-HSA-5604929 Reaction Name: Activated protein C binds Protein S See in Reactome R-HSA-5606996 ( R-HSA-140875 ) R-HSA-5606996 Reaction Name: Soluble PROCR binds activated protein C See in Reactome R-HSA-5607002 ( R-HSA-140875 ) R-HSA-5607002 Reaction Name: Activated protein C cleaves factor VIIIa See in Reactome R-HSA-5607058 ( R-HSA-140875 ) R-HSA-5607058 Reaction Name: Activated protein C:PROCR binds F2R See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome
MONDO:0013361	F2	P00734	3.4.21.5	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-375276 R-HSA-375276 Reactome Name: Peptide ligand-binding receptors See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-140875 R-HSA-140875 Reactome Name: Common Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome	R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-500792 R-HSA-500792 Reactome Name: GPCR ligand binding See in Reactome R-HSA-373076 R-HSA-373076 Reactome Name: Class A/1 (Rhodopsin-like receptors) See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114697 ( R-HSA-456926 ) R-HSA-114697 Reaction Name: Activated thrombin (factor IIa) cleaves PAR3,4, activating them See in Reactome R-HSA-140599 ( R-HSA-140875 ) R-HSA-140599 Reaction Name: factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides See in Reactome R-HSA-140664 ( R-HSA-140875 ) R-HSA-140664 Reaction Name: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) See in Reactome R-HSA-140696 ( R-HSA-140875 ) R-HSA-140696 Reaction Name: factor V -> factor Va + factor V activation peptide See in Reactome R-HSA-140700 ( R-HSA-140875 ) R-HSA-140700 Reaction Name: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) See in Reactome R-HSA-140791 ( R-HSA-140875 ) R-HSA-140791 Reaction Name: activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin See in Reactome R-HSA-140840 ( R-HSA-140875 ) R-HSA-140840 Reaction Name: fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B See in Reactome R-HSA-140870 ( R-HSA-140875 ) R-HSA-140870 Reaction Name: thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin See in Reactome R-HSA-140872 ( R-HSA-140875 ) R-HSA-140872 Reaction Name: thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators See in Reactome R-HSA-141040 ( R-HSA-140875; R-HSA-202733 ) R-HSA-141040 Reaction Name: Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C See in Reactome R-HSA-141046 ( R-HSA-140875 ) R-HSA-141046 Reaction Name: activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin See in Reactome R-HSA-158137 ( R-HSA-140837 ) R-HSA-158137 Reaction Name: factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer See in Reactome R-HSA-158419 ( R-HSA-140837 ) R-HSA-158419 Reaction Name: factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) See in Reactome R-HSA-159728 ( R-HSA-159782 ) R-HSA-159728 Reaction Name: Furin cleaves pro-prothrombin to prothrombin See in Reactome R-HSA-159826 ( R-HSA-159740 ) R-HSA-159826 Reaction Name: GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) See in Reactome R-HSA-159843 ( R-HSA-159763 ) R-HSA-159843 Reaction Name: Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-379048 ( R-HSA-416476 ) R-HSA-379048 Reaction Name: Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 See in Reactome R-HSA-381446 ( R-HSA-381426 ) R-HSA-381446 Reaction Name: Thrombin proteolyzes IGF:IGFBP3:ALS See in Reactome R-HSA-389463 ( R-HSA-375276 ) R-HSA-389463 Reaction Name: Proteinase-activated receptors can bind thrombin See in Reactome R-HSA-429529 ( R-HSA-76009 ) R-HSA-429529 Reaction Name: Thrombin binding to GP1b:IX:V See in Reactome R-HSA-5578883 ( R-HSA-140875 ) R-HSA-5578883 Reaction Name: Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) See in Reactome R-HSA-5602080 ( R-HSA-140875 ) R-HSA-5602080 Reaction Name: Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. See in Reactome R-HSA-749448 ( R-HSA-416476 ) R-HSA-749448 Reaction Name: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq See in Reactome R-HSA-749452 ( R-HSA-416476 ) R-HSA-749452 Reaction Name: The Ligand:GPCR:Gq complex dissociates See in Reactome R-HSA-8852716 ( R-HSA-977606 ) R-HSA-8852716 Reaction Name: Thrombin, ELANE cleave C5 See in Reactome R-HSA-9015379 ( R-HSA-140837 ) R-HSA-9015379 Reaction Name: Factor IIa inhibitors (compounds) binds IIa See in Reactome R-HSA-9603302 ( R-HSA-140837 ) R-HSA-9603302 Reaction Name: Factor IIa inhibitors (peptide) binds IIa See in Reactome R-HSA-9708859 ( R-HSA-456926 ) R-HSA-9708859 Reaction Name: Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it See in Reactome
MONDO:0013728	F2	P00734	3.4.21.5	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-375276 R-HSA-375276 Reactome Name: Peptide ligand-binding receptors See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-140875 R-HSA-140875 Reactome Name: Common Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome	R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-500792 R-HSA-500792 Reactome Name: GPCR ligand binding See in Reactome R-HSA-373076 R-HSA-373076 Reactome Name: Class A/1 (Rhodopsin-like receptors) See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114697 ( R-HSA-456926 ) R-HSA-114697 Reaction Name: Activated thrombin (factor IIa) cleaves PAR3,4, activating them See in Reactome R-HSA-140599 ( R-HSA-140875 ) R-HSA-140599 Reaction Name: factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides See in Reactome R-HSA-140664 ( R-HSA-140875 ) R-HSA-140664 Reaction Name: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) See in Reactome R-HSA-140696 ( R-HSA-140875 ) R-HSA-140696 Reaction Name: factor V -> factor Va + factor V activation peptide See in Reactome R-HSA-140700 ( R-HSA-140875 ) R-HSA-140700 Reaction Name: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) See in Reactome R-HSA-140791 ( R-HSA-140875 ) R-HSA-140791 Reaction Name: activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin See in Reactome R-HSA-140840 ( R-HSA-140875 ) R-HSA-140840 Reaction Name: fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B See in Reactome R-HSA-140870 ( R-HSA-140875 ) R-HSA-140870 Reaction Name: thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin See in Reactome R-HSA-140872 ( R-HSA-140875 ) R-HSA-140872 Reaction Name: thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators See in Reactome R-HSA-141040 ( R-HSA-140875; R-HSA-202733 ) R-HSA-141040 Reaction Name: Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C See in Reactome R-HSA-141046 ( R-HSA-140875 ) R-HSA-141046 Reaction Name: activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin See in Reactome R-HSA-158137 ( R-HSA-140837 ) R-HSA-158137 Reaction Name: factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer See in Reactome R-HSA-158419 ( R-HSA-140837 ) R-HSA-158419 Reaction Name: factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) See in Reactome R-HSA-159728 ( R-HSA-159782 ) R-HSA-159728 Reaction Name: Furin cleaves pro-prothrombin to prothrombin See in Reactome R-HSA-159826 ( R-HSA-159740 ) R-HSA-159826 Reaction Name: GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) See in Reactome R-HSA-159843 ( R-HSA-159763 ) R-HSA-159843 Reaction Name: Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-379048 ( R-HSA-416476 ) R-HSA-379048 Reaction Name: Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 See in Reactome R-HSA-381446 ( R-HSA-381426 ) R-HSA-381446 Reaction Name: Thrombin proteolyzes IGF:IGFBP3:ALS See in Reactome R-HSA-389463 ( R-HSA-375276 ) R-HSA-389463 Reaction Name: Proteinase-activated receptors can bind thrombin See in Reactome R-HSA-429529 ( R-HSA-76009 ) R-HSA-429529 Reaction Name: Thrombin binding to GP1b:IX:V See in Reactome R-HSA-5578883 ( R-HSA-140875 ) R-HSA-5578883 Reaction Name: Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) See in Reactome R-HSA-5602080 ( R-HSA-140875 ) R-HSA-5602080 Reaction Name: Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. See in Reactome R-HSA-749448 ( R-HSA-416476 ) R-HSA-749448 Reaction Name: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq See in Reactome R-HSA-749452 ( R-HSA-416476 ) R-HSA-749452 Reaction Name: The Ligand:GPCR:Gq complex dissociates See in Reactome R-HSA-8852716 ( R-HSA-977606 ) R-HSA-8852716 Reaction Name: Thrombin, ELANE cleave C5 See in Reactome R-HSA-9015379 ( R-HSA-140837 ) R-HSA-9015379 Reaction Name: Factor IIa inhibitors (compounds) binds IIa See in Reactome R-HSA-9603302 ( R-HSA-140837 ) R-HSA-9603302 Reaction Name: Factor IIa inhibitors (peptide) binds IIa See in Reactome R-HSA-9708859 ( R-HSA-456926 ) R-HSA-9708859 Reaction Name: Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it See in Reactome
MONDO:0014234	ADAM10	O14672	3.4.24.81	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-977225 R-HSA-977225 Reactome Name: Amyloid fiber formation See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Metabolism of proteins Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-157629 ( R-HSA-2979096 ) R-HSA-157629 Reaction Name: NOTCH2-ligand complex is cleaved to produce NEXT2 See in Reactome R-HSA-157632 ( R-HSA-2122948 ) R-HSA-157632 Reaction Name: Complex of NOTCH1 with its ligand is cleaved to produce NEXT1 See in Reactome R-HSA-177946 ( R-HSA-177929 ) R-HSA-177946 Reaction Name: Pro-EGF is cleaved to form mature EGF See in Reactome R-HSA-2168960 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168960 Reaction Name: Collagen type XVII ectodomain shedding See in Reactome R-HSA-3928660 ( R-HSA-3928665 ) R-HSA-3928660 Reaction Name: ADAM10 cleaves EFNAs See in Reactome R-HSA-4224014 ( R-HSA-1474228 ) R-HSA-4224014 Reaction Name: E-cadherin degradation by ADAM10, ADAM15 See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-6799350 ( R-HSA-6798695 ) R-HSA-6799350 Reaction Name: Exocytosis of specific granule membrane proteins See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome R-HSA-9010034 ( R-HSA-977225 ) R-HSA-9010034 Reaction Name: ADAM10:Zn2+:TSPANs cleaves APP(18-770) See in Reactome R-HSA-9010074 ( R-HSA-977225 ) R-HSA-9010074 Reaction Name: ADAM10:Zn2+:TSPANs translocates from ER lumen to plasma membrane See in Reactome R-HSA-9010113 ( R-HSA-977225 ) R-HSA-9010113 Reaction Name: ADAM10:Zn2+ binds TSPANs See in Reactome R-HSA-9013284 ( R-HSA-9013507 ) R-HSA-9013284 Reaction Name: NOTCH3-ligand complex is cleaved to produce NEXT3 See in Reactome R-HSA-9604264 ( R-HSA-9013700 ) R-HSA-9604264 Reaction Name: ADAM10 cleaves NOTCH4 See in Reactome
MONDO:0014265	ADAM10	O14672	3.4.24.81	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-977225 R-HSA-977225 Reactome Name: Amyloid fiber formation See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Metabolism of proteins Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-157629 ( R-HSA-2979096 ) R-HSA-157629 Reaction Name: NOTCH2-ligand complex is cleaved to produce NEXT2 See in Reactome R-HSA-157632 ( R-HSA-2122948 ) R-HSA-157632 Reaction Name: Complex of NOTCH1 with its ligand is cleaved to produce NEXT1 See in Reactome R-HSA-177946 ( R-HSA-177929 ) R-HSA-177946 Reaction Name: Pro-EGF is cleaved to form mature EGF See in Reactome R-HSA-2168960 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168960 Reaction Name: Collagen type XVII ectodomain shedding See in Reactome R-HSA-3928660 ( R-HSA-3928665 ) R-HSA-3928660 Reaction Name: ADAM10 cleaves EFNAs See in Reactome R-HSA-4224014 ( R-HSA-1474228 ) R-HSA-4224014 Reaction Name: E-cadherin degradation by ADAM10, ADAM15 See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-6799350 ( R-HSA-6798695 ) R-HSA-6799350 Reaction Name: Exocytosis of specific granule membrane proteins See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome R-HSA-9010034 ( R-HSA-977225 ) R-HSA-9010034 Reaction Name: ADAM10:Zn2+:TSPANs cleaves APP(18-770) See in Reactome R-HSA-9010074 ( R-HSA-977225 ) R-HSA-9010074 Reaction Name: ADAM10:Zn2+:TSPANs translocates from ER lumen to plasma membrane See in Reactome R-HSA-9010113 ( R-HSA-977225 ) R-HSA-9010113 Reaction Name: ADAM10:Zn2+ binds TSPANs See in Reactome R-HSA-9013284 ( R-HSA-9013507 ) R-HSA-9013284 Reaction Name: NOTCH3-ligand complex is cleaved to produce NEXT3 See in Reactome R-HSA-9604264 ( R-HSA-9013700 ) R-HSA-9604264 Reaction Name: ADAM10 cleaves NOTCH4 See in Reactome
MONDO:0017094	FAM20C	Q8IXL6	2.7.11.1	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Metabolism of proteins	R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome
MONDO:0018298	MMP2	P08253	3.4.24.24	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Metabolism of proteins Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1454757 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454757 Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 See in Reactome R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1454791 ( R-HSA-1474228 ) R-HSA-1454791 Reaction Name: MMP2, MMP7, MMP9 bind CD44 See in Reactome R-HSA-1454822 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454822 Reaction Name: Collagen type I degradation by MMP1,2,8,13, PRSS2 See in Reactome R-HSA-1564112 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564112 Reaction Name: Collagen type VI degradation by MMP2,9,11 See in Reactome R-HSA-1564120 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564120 Reaction Name: Collagen type VII degradation by MMP1,2,3 See in Reactome R-HSA-1564142 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564142 Reaction Name: Collagen type IV degradation by MMP2,3,4,9,10,12 See in Reactome R-HSA-1564143 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564143 Reaction Name: Collagen type X degradation by MMP1,2 See in Reactome R-HSA-1564164 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564164 Reaction Name: Collagen type V degradation by MMP2,9,10 See in Reactome R-HSA-1564179 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564179 Reaction Name: Collagen type XI degradation by MMP1,2,3,9 See in Reactome R-HSA-1566962 ( R-HSA-1474228 ) R-HSA-1566962 Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-1592278 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592278 Reaction Name: Autocatalytic activation of proMMP2 See in Reactome R-HSA-1592297 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592297 Reaction Name: Full activation of MMP1 See in Reactome R-HSA-1592436 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592436 Reaction Name: Initial activation of proMMP9 by MMPs See in Reactome R-HSA-1604350 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604350 Reaction Name: MMP14:TIMP2 binds proMMP2 See in Reactome R-HSA-1604359 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604359 Reaction Name: Initial activation of proMMP2 by MMP1, 7 See in Reactome R-HSA-1604360 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604360 Reaction Name: Initial activation of proMMP2 by MMP14 See in Reactome R-HSA-1604368 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604368 Reaction Name: Autocatalytic activation of bound proMMP2 See in Reactome R-HSA-1604690 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604690 Reaction Name: Activation of MMP9 intermediate form by MMPs See in Reactome R-HSA-2485148 ( R-HSA-1474228 ) R-HSA-2485148 Reaction Name: Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 See in Reactome R-HSA-2534248 ( R-HSA-1474228 ) R-HSA-2534248 Reaction Name: DCN (decorin) degradation by MMP2, MMP3, MMP7 See in Reactome R-HSA-3791149 ( R-HSA-1474228 ) R-HSA-3791149 Reaction Name: Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 See in Reactome R-HSA-3791295 ( R-HSA-1474228 ) R-HSA-3791295 Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13 See in Reactome R-HSA-381435 ( R-HSA-381426 ) R-HSA-381435 Reaction Name: Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS See in Reactome R-HSA-3928657 ( R-HSA-3928665 ) R-HSA-3928657 Reaction Name: MMP2,9 cleave EPHB See in Reactome R-HSA-6789615 ( R-HSA-6785807 ) R-HSA-6789615 Reaction Name: Expression of STAT3-upregulated extracellular proteins See in Reactome R-HSA-8940554 ( R-HSA-1474228 ) R-HSA-8940554 Reaction Name: MMP2 cleaves OPTC See in Reactome R-HSA-8943959 ( R-HSA-1474228 ) R-HSA-8943959 Reaction Name: MMP2, MMP9 cleave SCUBE3 See in Reactome R-HSA-9624272 ( R-HSA-9009391 ) R-HSA-9624272 Reaction Name: MMPs cleave HB-EGF See in Reactome
MONDO:0018328	PCSK9	Q8NBP7	3.4.21.-	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome R-HSA-8866427 R-HSA-8866427 Reactome Name: VLDLR internalisation and degradation See in Reactome R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Transport of small molecules Metabolism of proteins	R-HSA-6784729 ( R-HSA-8964038 ) R-HSA-6784729 Reaction Name: PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome See in Reactome R-HSA-6784734 ( R-HSA-8964038 ) R-HSA-6784734 Reaction Name: PCSK9 binds LDLR See in Reactome R-HSA-6784735 ( R-HSA-8964038 ) R-HSA-6784735 Reaction Name: PCSK9:LDLR bind to Clathrin See in Reactome R-HSA-6784738 ( R-HSA-8964038 ) R-HSA-6784738 Reaction Name: Degradation of PCSK9:LDLR:Clathrin-coated vesicle See in Reactome R-HSA-8855111 ( R-HSA-8866427 ) R-HSA-8855111 Reaction Name: VLDLR binds PCSK9 See in Reactome R-HSA-8855130 ( R-HSA-8866427 ) R-HSA-8855130 Reaction Name: VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane See in Reactome R-HSA-8855131 ( R-HSA-8866427 ) R-HSA-8855131 Reaction Name: VLDLR:PCSK9 binds Clathrin-coated vesicles See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome
MONDO:0019623	PLG	P00747	3.4.21.7	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-75205 R-HSA-75205 Reactome Name: Dissolution of Fibrin Clot See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome	R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Extracellular matrix organization Hemostasis Signal Transduction	R-HSA-1454843 ( R-HSA-1474228 ) R-HSA-1454843 Reaction Name: E-cadherin degradation by MMP3, MMP7 and plasmin. See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-158721 ( R-HSA-75205 ) R-HSA-158721 Reaction Name: histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen See in Reactome R-HSA-158722 ( R-HSA-75205 ) R-HSA-158722 Reaction Name: histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen See in Reactome R-HSA-158744 ( R-HSA-75205 ) R-HSA-158744 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin See in Reactome R-HSA-158747 ( R-HSA-75205 ) R-HSA-158747 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) See in Reactome R-HSA-158750 ( R-HSA-75205 ) R-HSA-158750 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin See in Reactome R-HSA-158756 ( R-HSA-75205 ) R-HSA-158756 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen See in Reactome R-HSA-158766 ( R-HSA-75205 ) R-HSA-158766 Reaction Name: fibrin multimer, crosslinked -> fibrin digestion products (plasmin) See in Reactome R-HSA-158784 ( R-HSA-75205 ) R-HSA-158784 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen See in Reactome R-HSA-158893 ( R-HSA-75205 ) R-HSA-158893 Reaction Name: alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin See in Reactome R-HSA-158925 ( R-HSA-75205 ) R-HSA-158925 Reaction Name: plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) See in Reactome R-HSA-158941 ( R-HSA-75205 ) R-HSA-158941 Reaction Name: plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein See in Reactome R-HSA-158942 ( R-HSA-75205 ) R-HSA-158942 Reaction Name: urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR See in Reactome R-HSA-158982 ( R-HSA-75205 ) R-HSA-158982 Reaction Name: plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) See in Reactome R-HSA-1592314 ( R-HSA-1474228 ) R-HSA-1592314 Reaction Name: HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) See in Reactome R-HSA-1592316 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592316 Reaction Name: Initial activation of proMMP1 See in Reactome R-HSA-1592371 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592371 Reaction Name: Initial activation of proMMP3 See in Reactome R-HSA-1592398 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592398 Reaction Name: Activation of proMMP8 See in Reactome R-HSA-1602458 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602458 Reaction Name: Activation of proMMP10 See in Reactome R-HSA-1602488 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602488 Reaction Name: Initial activation of proMMP13 by plasmin and trypsin See in Reactome R-HSA-1604712 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604712 Reaction Name: Initial activation of proMMP7 by trypsin See in Reactome R-HSA-381461 ( R-HSA-381426 ) R-HSA-381461 Reaction Name: Plasmin proteolyzes IGF:IGFBP-3:ALS See in Reactome R-HSA-382061 ( R-HSA-186797 ) R-HSA-382061 Reaction Name: Extracellular processing of novel PDGFs See in Reactome R-HSA-481007 ( R-HSA-114608 ) R-HSA-481007 Reaction Name: Exocytosis of platelet alpha granule contents See in Reactome
MONDO:0032721	MBTPS1	Q14703	3.4.21.112	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-8874211 R-HSA-8874211 Reactome Name: CREB3 factors activate genes See in Reactome R-HSA-381033 R-HSA-381033 Reactome Name: ATF6 (ATF6-alpha) activates chaperones See in Reactome R-HSA-1655829 R-HSA-1655829 Reactome Name: Regulation of cholesterol biosynthesis by SREBP (SREBF) See in Reactome R-HSA-8963889 R-HSA-8963889 Reactome Name: Assembly of active LPL and LIPC lipase complexes See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome	R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Cellular responses to stimuli Metabolism of proteins Metabolism Transport of small molecules	R-HSA-1655842 ( R-HSA-1655829 ) R-HSA-1655842 Reaction Name: S1P hydrolyzes SREBP1A,1C,2 See in Reactome R-HSA-381135 ( R-HSA-381033 ) R-HSA-381135 Reaction Name: MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) See in Reactome R-HSA-6784620 ( R-HSA-8963889 ) R-HSA-6784620 Reaction Name: MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461) See in Reactome R-HSA-8874186 ( R-HSA-8874211 ) R-HSA-8874186 Reaction Name: MBTPS1 (S1P) cleaves CREB3L4 See in Reactome R-HSA-8874204 ( R-HSA-8874211 ) R-HSA-8874204 Reaction Name: MBTPS1 (S1P) cleaves CREB3 See in Reactome R-HSA-8874205 ( R-HSA-8874211 ) R-HSA-8874205 Reaction Name: MBTPS1 (S1P) cleaves CREB3L2 See in Reactome R-HSA-8874206 ( R-HSA-8874211 ) R-HSA-8874206 Reaction Name: MBTPS1 (S1P) cleaves CREB3L3 See in Reactome R-HSA-8874212 ( R-HSA-8874211 ) R-HSA-8874212 Reaction Name: MBTPS1 (S1P) cleaves CREB3L1 See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome

Number of enzymes:	12
Number of disease:	22
Number of reactomes:	47
Number of reactions:	149

Search summary (Reactome ID: R-HSA-381426)

Search results (Reactome ID: R-HSA-381426)

MONDO:0007204

R-HSA-381426

R-HSA-9020591

R-HSA-8963888

R-HSA-8964041

R-HSA-5358346

R-HSA-9020933

R-HSA-1650814

R-HSA-3299685

R-HSA-8866423

R-HSA-8957275

R-HSA-8963899

R-HSA-174824

R-HSA-449147

R-HSA-447115

R-HSA-8953897

R-HSA-168256

R-HSA-2262752

R-HSA-382551

R-HSA-1280215

R-HSA-1474290

R-HSA-1474244

R-HSA-8963898

R-HSA-392499

R-HSA-5358351

R-HSA-597592

R-HSA-162582

R-HSA-9711123

R-HSA-1650808

R-HSA-174741

R-HSA-174786

R-HSA-2002460

R-HSA-3341296

R-HSA-5358336

R-HSA-5358340

R-HSA-8866329

R-HSA-8948234

R-HSA-8950113

R-HSA-8950183

R-HSA-8950456

R-HSA-8952289

R-HSA-9737780

MONDO:0007750

R-HSA-381426

R-HSA-8957275

R-HSA-8866427

R-HSA-8964038

R-HSA-597592

R-HSA-382551

R-HSA-174824

R-HSA-8964043

R-HSA-392499

R-HSA-6784729

R-HSA-6784734

R-HSA-6784735

R-HSA-6784738

R-HSA-8855111

R-HSA-8855130

R-HSA-8855131

R-HSA-8952289

MONDO:0008146

R-HSA-381426

R-HSA-9020591

R-HSA-8963888

R-HSA-8964041

R-HSA-5358346

R-HSA-9020933

R-HSA-1650814

R-HSA-3299685

R-HSA-8866423

R-HSA-8957275

R-HSA-8963899

R-HSA-174824

R-HSA-449147

R-HSA-447115

R-HSA-8953897

R-HSA-168256

R-HSA-2262752