DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-380994)

Number of enzymes:	3
Number of disease:	6
Number of reactomes:	10
Number of reactions:	9

Search results (Reactome ID: R-HSA-380994)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009693	DIS3	Q9Y2L1	3.1.13.- 3.1.26.-	R-HSA-429958 R-HSA-429958 Reactome Name: mRNA decay by 3' to 5' exoribonuclease See in Reactome R-HSA-450385 R-HSA-450385 Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA See in Reactome R-HSA-380994 R-HSA-380994 Reactome Name: ATF4 activates genes in response to endoplasmic reticulum stress See in Reactome R-HSA-6791226 R-HSA-6791226 Reactome Name: Major pathway of rRNA processing in the nucleolus and cytosol See in Reactome R-HSA-450513 R-HSA-450513 Reactome Name: Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA See in Reactome R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome	R-HSA-381042 R-HSA-381042 Reactome Name: PERK regulates gene expression See in Reactome R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-8868773 R-HSA-8868773 Reactome Name: rRNA processing in the nucleus and cytosol See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-429914 R-HSA-429914 Reactome Name: Deadenylation-dependent mRNA decay See in Reactome R-HSA-72312 R-HSA-72312 Reactome Name: rRNA processing See in Reactome	Cellular responses to stimuli Metabolism of RNA	R-HSA-430028 ( R-HSA-429958 ) R-HSA-430028 Reaction Name: Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion See in Reactome R-HSA-450422 ( R-HSA-450604 ) R-HSA-450422 Reaction Name: KSRP recruits RNA degradation activities See in Reactome R-HSA-450431 ( R-HSA-450513 ) R-HSA-450431 Reaction Name: ZFP36 (TTP) recruits RNA degradation activities See in Reactome R-HSA-450488 ( R-HSA-450385 ) R-HSA-450488 Reaction Name: BRF1 Complex recruits RNA degradation activities See in Reactome R-HSA-517731 ( R-HSA-380994 ) R-HSA-517731 Reaction Name: Expression of IL-8 See in Reactome R-HSA-6791218 ( R-HSA-6791226 ) R-HSA-6791218 Reaction Name: 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA See in Reactome
MONDO:0014258	ASNS	P08243	6.3.5.4	R-HSA-9633012 R-HSA-9633012 Reactome Name: Response of EIF2AK4 (GCN2) to amino acid deficiency See in Reactome R-HSA-380994 R-HSA-380994 Reactome Name: ATF4 activates genes in response to endoplasmic reticulum stress See in Reactome R-HSA-9648895 R-HSA-9648895 Reactome Name: Response of EIF2AK1 (HRI) to heme deficiency See in Reactome R-HSA-8963693 R-HSA-8963693 Reactome Name: Aspartate and asparagine metabolism See in Reactome	R-HSA-381042 R-HSA-381042 Reactome Name: PERK regulates gene expression See in Reactome R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome	Cellular responses to stimuli Metabolism	R-HSA-1791118 ( R-HSA-380994; R-HSA-9633012; R-HSA-9648895 ) R-HSA-1791118 Reaction Name: Expression of ASNS (Asparagine Synthetase) See in Reactome R-HSA-70599 ( R-HSA-8963693 ) R-HSA-70599 Reaction Name: aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] See in Reactome
MONDO:0014600	PARN	O95453	3.1.13.4	R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-380994 R-HSA-380994 Reactome Name: ATF4 activates genes in response to endoplasmic reticulum stress See in Reactome R-HSA-429947 R-HSA-429947 Reactome Name: Deadenylation of mRNA See in Reactome	R-HSA-381042 R-HSA-381042 Reactome Name: PERK regulates gene expression See in Reactome R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-429914 R-HSA-429914 Reactome Name: Deadenylation-dependent mRNA decay See in Reactome	Cellular responses to stimuli Metabolism of RNA	R-HSA-429992 ( R-HSA-429947 ) R-HSA-429992 Reaction Name: PARN deadenylates mRNA See in Reactome R-HSA-450422 ( R-HSA-450604 ) R-HSA-450422 Reaction Name: KSRP recruits RNA degradation activities See in Reactome R-HSA-517731 ( R-HSA-380994 ) R-HSA-517731 Reaction Name: Expression of IL-8 See in Reactome
MONDO:0014612	PARN	O95453	3.1.13.4	R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-380994 R-HSA-380994 Reactome Name: ATF4 activates genes in response to endoplasmic reticulum stress See in Reactome R-HSA-429947 R-HSA-429947 Reactome Name: Deadenylation of mRNA See in Reactome	R-HSA-381042 R-HSA-381042 Reactome Name: PERK regulates gene expression See in Reactome R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-429914 R-HSA-429914 Reactome Name: Deadenylation-dependent mRNA decay See in Reactome	Cellular responses to stimuli Metabolism of RNA	R-HSA-429992 ( R-HSA-429947 ) R-HSA-429992 Reaction Name: PARN deadenylates mRNA See in Reactome R-HSA-450422 ( R-HSA-450604 ) R-HSA-450422 Reaction Name: KSRP recruits RNA degradation activities See in Reactome R-HSA-517731 ( R-HSA-380994 ) R-HSA-517731 Reaction Name: Expression of IL-8 See in Reactome
MONDO:0018045	PARN	O95453	3.1.13.4	R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-380994 R-HSA-380994 Reactome Name: ATF4 activates genes in response to endoplasmic reticulum stress See in Reactome R-HSA-429947 R-HSA-429947 Reactome Name: Deadenylation of mRNA See in Reactome	R-HSA-381042 R-HSA-381042 Reactome Name: PERK regulates gene expression See in Reactome R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-429914 R-HSA-429914 Reactome Name: Deadenylation-dependent mRNA decay See in Reactome	Cellular responses to stimuli Metabolism of RNA	R-HSA-429992 ( R-HSA-429947 ) R-HSA-429992 Reaction Name: PARN deadenylates mRNA See in Reactome R-HSA-450422 ( R-HSA-450604 ) R-HSA-450422 Reaction Name: KSRP recruits RNA degradation activities See in Reactome R-HSA-517731 ( R-HSA-380994 ) R-HSA-517731 Reaction Name: Expression of IL-8 See in Reactome
MONDO:0019438	DIS3	Q9Y2L1	3.1.13.- 3.1.26.-	R-HSA-429958 R-HSA-429958 Reactome Name: mRNA decay by 3' to 5' exoribonuclease See in Reactome R-HSA-450385 R-HSA-450385 Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA See in Reactome R-HSA-380994 R-HSA-380994 Reactome Name: ATF4 activates genes in response to endoplasmic reticulum stress See in Reactome R-HSA-6791226 R-HSA-6791226 Reactome Name: Major pathway of rRNA processing in the nucleolus and cytosol See in Reactome R-HSA-450513 R-HSA-450513 Reactome Name: Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA See in Reactome R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome	R-HSA-381042 R-HSA-381042 Reactome Name: PERK regulates gene expression See in Reactome R-HSA-381119 R-HSA-381119 Reactome Name: Unfolded Protein Response (UPR) See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-8868773 R-HSA-8868773 Reactome Name: rRNA processing in the nucleus and cytosol See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-429914 R-HSA-429914 Reactome Name: Deadenylation-dependent mRNA decay See in Reactome R-HSA-72312 R-HSA-72312 Reactome Name: rRNA processing See in Reactome	Cellular responses to stimuli Metabolism of RNA	R-HSA-430028 ( R-HSA-429958 ) R-HSA-430028 Reaction Name: Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion See in Reactome R-HSA-450422 ( R-HSA-450604 ) R-HSA-450422 Reaction Name: KSRP recruits RNA degradation activities See in Reactome R-HSA-450431 ( R-HSA-450513 ) R-HSA-450431 Reaction Name: ZFP36 (TTP) recruits RNA degradation activities See in Reactome R-HSA-450488 ( R-HSA-450385 ) R-HSA-450488 Reaction Name: BRF1 Complex recruits RNA degradation activities See in Reactome R-HSA-517731 ( R-HSA-380994 ) R-HSA-517731 Reaction Name: Expression of IL-8 See in Reactome R-HSA-6791218 ( R-HSA-6791226 ) R-HSA-6791218 Reaction Name: 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA See in Reactome