MONDO:0004948 |
ATM |
Q13315 |
2.7.11.1
|
R-HSA-2559586
R-HSA-2559586
Reactome Name: DNA Damage/Telomere Stress Induced Senescence
See in Reactome
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-9664873
R-HSA-69473
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-69541
R-HSA-6803207
R-HSA-6803207
Reactome Name: TP53 Regulates Transcription of Caspase Activators and Caspases
See in Reactome
R-HSA-6803204
R-HSA-6803204
Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5693548
R-HSA-5693548
Reactome Name: Sensing of DNA Double Strand Breaks
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-912446
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-2559583
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-1640170
R-HSA-8953897
R-HSA-73857
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-5633007
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-5633008
R-HSA-5633008
Reactome Name: TP53 Regulates Transcription of Cell Death Genes
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-5693538
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-1474165
R-HSA-9612973
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-9663891
R-HSA-1632852
R-HSA-69481
R-HSA-69615
R-HSA-1500620
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
|
Cell Cycle
Cellular responses to stimuli
Gene expression (Transcription)
Reproduction
Autophagy
DNA Repair
|
R-HSA-3371567
(
R-HSA-3371453
)
R-HSA-3371567
Reaction Name: DBC1 is phosphorylated by ATM/ART
See in Reactome
R-HSA-349444
(
R-HSA-349425;
R-HSA-69541
)
R-HSA-349444
Reaction Name: Phosphorylation of COP1 at Ser-387 by ATM
See in Reactome
R-HSA-349455
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-5682018
(
R-HSA-2559586
)
R-HSA-5682018
Reaction Name: MRN complex bound to shortened telomeres recruits ATM
See in Reactome
R-HSA-5682026
(
R-HSA-2559586
)
R-HSA-5682026
Reaction Name: MRN bound to shortened telomeres activates ATM
See in Reactome
R-HSA-5682044
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5682044
Reaction Name: KAT5 acetylates ATM at DNA DSBs
See in Reactome
R-HSA-5682586
(
R-HSA-5693565
)
R-HSA-5682586
Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs
See in Reactome
R-HSA-5682588
(
R-HSA-5693565
)
R-HSA-5682588
Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs
See in Reactome
R-HSA-5682598
(
R-HSA-5693565
)
R-HSA-5682607
(
R-HSA-5693565
)
R-HSA-5682607
Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
See in Reactome
R-HSA-5682629
(
R-HSA-5693565
)
R-HSA-5682629
Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
See in Reactome
R-HSA-5682858
(
R-HSA-5693565
)
R-HSA-5682858
Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX
See in Reactome
R-HSA-5682863
(
R-HSA-5693565
)
R-HSA-5682965
(
R-HSA-5693565
)
R-HSA-5682965
Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs
See in Reactome
R-HSA-5682967
(
R-HSA-5693565
)
R-HSA-5682983
(
R-HSA-5693565
)
R-HSA-5682992
(
R-HSA-5693565
)
R-HSA-5683077
(
R-HSA-5693565
)
R-HSA-5683077
Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B
See in Reactome
R-HSA-5683384
(
R-HSA-5693565
)
R-HSA-5683384
Reaction Name: UIMC1 and FAM175A bind DNA DSBs
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683405
(
R-HSA-5693565
)
R-HSA-5683405
Reaction Name: PPP5C dephosphorylates TP53BP1
See in Reactome
R-HSA-5683425
(
R-HSA-5693565
)
R-HSA-5683425
Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
R-HSA-5683986
(
R-HSA-5693565
)
R-HSA-5683986
Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX
See in Reactome
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684081
(
R-HSA-5693607
)
R-HSA-5684081
Reaction Name: MRN complex binds CDK2 and RBBP8
See in Reactome
R-HSA-5684096
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684140
(
R-HSA-5693607
)
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686578
(
R-HSA-5693565
)
R-HSA-5686578
Reaction Name: Activated ATM phosphorylates ABL1
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5686704
(
R-HSA-5693571
)
R-HSA-5686704
Reaction Name: Activated ATM phosphorylates DCLRE1C
See in Reactome
R-HSA-5686900
(
R-HSA-5693571
)
R-HSA-5686900
Reaction Name: TP53BP1 recruits DCLRE1C to ATM
See in Reactome
R-HSA-5693536
(
R-HSA-5693565
)
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693540
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693549
(
R-HSA-5693565
)
R-HSA-5693549
Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693566
(
R-HSA-5693565
)
R-HSA-5693566
Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693583
(
R-HSA-5693565
)
R-HSA-5693583
Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693598
(
R-HSA-5693565
)
R-HSA-5693599
(
R-HSA-5693571
)
R-HSA-5693599
Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break
See in Reactome
R-HSA-5693602
(
R-HSA-5693565
)
R-HSA-5693602
Reaction Name: ATM recognizes H2AFX-Nucleosomes
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693609
(
R-HSA-2559586;
R-HSA-5693565;
R-HSA-6804756;
R-HSA-69541
)
R-HSA-5693609
Reaction Name: ATM phosphorylates TP53 at S15
See in Reactome
R-HSA-5693612
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693612
Reaction Name: MRN complex bound to DNA ends recruits ATM
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6792712
(
R-HSA-2559586
)
R-HSA-6792712
Reaction Name: KAT5 acetylates ATM at shortened telomeres
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6798372
(
R-HSA-6804756
)
R-HSA-6799097
(
R-HSA-6803204
)
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-6800490
(
R-HSA-6803207
)
R-HSA-6804276
(
R-HSA-6804760
)
R-HSA-6804741
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-6804741
Reaction Name: MDM2 forms homo- or heterodimers
See in Reactome
R-HSA-6804955
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-912429
(
R-HSA-912446
)
R-HSA-912429
Reaction Name: Resolution of meiotic holliday junction
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912496
(
R-HSA-912446
)
R-HSA-912496
Reaction Name: Formation of meiotic holliday junction
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9664850
(
R-HSA-9664873
)
R-HSA-9664855
(
R-HSA-9664873
)
R-HSA-9664855
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664862
(
R-HSA-9664873
)
R-HSA-9664862
Reaction Name: ATM dimer:PEX5 phosphorylates PEX5
See in Reactome
R-HSA-9664879
(
R-HSA-9664873
)
R-HSA-9664880
(
R-HSA-9664873
)
R-HSA-9664880
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1
See in Reactome
R-HSA-9664881
(
R-HSA-9664873
)
R-HSA-9664881
Reaction Name: NBR1 binds ATM:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664883
(
R-HSA-9664873
)
R-HSA-9664883
Reaction Name: ATM:PEX5 translocates from cytosol to peroxisomal membrane
See in Reactome
R-HSA-9664888
(
R-HSA-9664873
)
R-HSA-9664888
Reaction Name: ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9664892
(
R-HSA-9664873
)
R-HSA-9664892
Reaction Name: SQSTM1 binds ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674127
(
R-HSA-9664873
)
R-HSA-9674127
Reaction Name: USP30 deubiquitinates ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674131
(
R-HSA-9664873
)
R-HSA-9674131
Reaction Name: USP30 binds ATM dimer:Ub-p-PEX5
See in Reactome
|
MONDO:0008840 |
ATM |
Q13315 |
2.7.11.1
|
R-HSA-2559586
R-HSA-2559586
Reactome Name: DNA Damage/Telomere Stress Induced Senescence
See in Reactome
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-9664873
R-HSA-69473
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-69541
R-HSA-6803207
R-HSA-6803207
Reactome Name: TP53 Regulates Transcription of Caspase Activators and Caspases
See in Reactome
R-HSA-6803204
R-HSA-6803204
Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5693548
R-HSA-5693548
Reactome Name: Sensing of DNA Double Strand Breaks
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-912446
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-2559583
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-1640170
R-HSA-8953897
R-HSA-73857
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-5633007
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-5633008
R-HSA-5633008
Reactome Name: TP53 Regulates Transcription of Cell Death Genes
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-5693538
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-1474165
R-HSA-9612973
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-9663891
R-HSA-1632852
R-HSA-69481
R-HSA-69615
R-HSA-1500620
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
|
Cell Cycle
Cellular responses to stimuli
Gene expression (Transcription)
Reproduction
Autophagy
DNA Repair
|
R-HSA-3371567
(
R-HSA-3371453
)
R-HSA-3371567
Reaction Name: DBC1 is phosphorylated by ATM/ART
See in Reactome
R-HSA-349444
(
R-HSA-349425;
R-HSA-69541
)
R-HSA-349444
Reaction Name: Phosphorylation of COP1 at Ser-387 by ATM
See in Reactome
R-HSA-349455
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-5682018
(
R-HSA-2559586
)
R-HSA-5682018
Reaction Name: MRN complex bound to shortened telomeres recruits ATM
See in Reactome
R-HSA-5682026
(
R-HSA-2559586
)
R-HSA-5682026
Reaction Name: MRN bound to shortened telomeres activates ATM
See in Reactome
R-HSA-5682044
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5682044
Reaction Name: KAT5 acetylates ATM at DNA DSBs
See in Reactome
R-HSA-5682586
(
R-HSA-5693565
)
R-HSA-5682586
Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs
See in Reactome
R-HSA-5682588
(
R-HSA-5693565
)
R-HSA-5682588
Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs
See in Reactome
R-HSA-5682598
(
R-HSA-5693565
)
R-HSA-5682607
(
R-HSA-5693565
)
R-HSA-5682607
Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
See in Reactome
R-HSA-5682629
(
R-HSA-5693565
)
R-HSA-5682629
Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
See in Reactome
R-HSA-5682858
(
R-HSA-5693565
)
R-HSA-5682858
Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX
See in Reactome
R-HSA-5682863
(
R-HSA-5693565
)
R-HSA-5682965
(
R-HSA-5693565
)
R-HSA-5682965
Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs
See in Reactome
R-HSA-5682967
(
R-HSA-5693565
)
R-HSA-5682983
(
R-HSA-5693565
)
R-HSA-5682992
(
R-HSA-5693565
)
R-HSA-5683077
(
R-HSA-5693565
)
R-HSA-5683077
Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B
See in Reactome
R-HSA-5683384
(
R-HSA-5693565
)
R-HSA-5683384
Reaction Name: UIMC1 and FAM175A bind DNA DSBs
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683405
(
R-HSA-5693565
)
R-HSA-5683405
Reaction Name: PPP5C dephosphorylates TP53BP1
See in Reactome
R-HSA-5683425
(
R-HSA-5693565
)
R-HSA-5683425
Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
R-HSA-5683986
(
R-HSA-5693565
)
R-HSA-5683986
Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX
See in Reactome
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684081
(
R-HSA-5693607
)
R-HSA-5684081
Reaction Name: MRN complex binds CDK2 and RBBP8
See in Reactome
R-HSA-5684096
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684140
(
R-HSA-5693607
)
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686578
(
R-HSA-5693565
)
R-HSA-5686578
Reaction Name: Activated ATM phosphorylates ABL1
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5686704
(
R-HSA-5693571
)
R-HSA-5686704
Reaction Name: Activated ATM phosphorylates DCLRE1C
See in Reactome
R-HSA-5686900
(
R-HSA-5693571
)
R-HSA-5686900
Reaction Name: TP53BP1 recruits DCLRE1C to ATM
See in Reactome
R-HSA-5693536
(
R-HSA-5693565
)
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693540
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693549
(
R-HSA-5693565
)
R-HSA-5693549
Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693566
(
R-HSA-5693565
)
R-HSA-5693566
Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693583
(
R-HSA-5693565
)
R-HSA-5693583
Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693598
(
R-HSA-5693565
)
R-HSA-5693599
(
R-HSA-5693571
)
R-HSA-5693599
Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break
See in Reactome
R-HSA-5693602
(
R-HSA-5693565
)
R-HSA-5693602
Reaction Name: ATM recognizes H2AFX-Nucleosomes
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693609
(
R-HSA-2559586;
R-HSA-5693565;
R-HSA-6804756;
R-HSA-69541
)
R-HSA-5693609
Reaction Name: ATM phosphorylates TP53 at S15
See in Reactome
R-HSA-5693612
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693612
Reaction Name: MRN complex bound to DNA ends recruits ATM
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6792712
(
R-HSA-2559586
)
R-HSA-6792712
Reaction Name: KAT5 acetylates ATM at shortened telomeres
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6798372
(
R-HSA-6804756
)
R-HSA-6799097
(
R-HSA-6803204
)
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-6800490
(
R-HSA-6803207
)
R-HSA-6804276
(
R-HSA-6804760
)
R-HSA-6804741
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-6804741
Reaction Name: MDM2 forms homo- or heterodimers
See in Reactome
R-HSA-6804955
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-912429
(
R-HSA-912446
)
R-HSA-912429
Reaction Name: Resolution of meiotic holliday junction
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912496
(
R-HSA-912446
)
R-HSA-912496
Reaction Name: Formation of meiotic holliday junction
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9664850
(
R-HSA-9664873
)
R-HSA-9664855
(
R-HSA-9664873
)
R-HSA-9664855
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664862
(
R-HSA-9664873
)
R-HSA-9664862
Reaction Name: ATM dimer:PEX5 phosphorylates PEX5
See in Reactome
R-HSA-9664879
(
R-HSA-9664873
)
R-HSA-9664880
(
R-HSA-9664873
)
R-HSA-9664880
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1
See in Reactome
R-HSA-9664881
(
R-HSA-9664873
)
R-HSA-9664881
Reaction Name: NBR1 binds ATM:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664883
(
R-HSA-9664873
)
R-HSA-9664883
Reaction Name: ATM:PEX5 translocates from cytosol to peroxisomal membrane
See in Reactome
R-HSA-9664888
(
R-HSA-9664873
)
R-HSA-9664888
Reaction Name: ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9664892
(
R-HSA-9664873
)
R-HSA-9664892
Reaction Name: SQSTM1 binds ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674127
(
R-HSA-9664873
)
R-HSA-9674127
Reaction Name: USP30 deubiquitinates ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674131
(
R-HSA-9664873
)
R-HSA-9674131
Reaction Name: USP30 binds ATM dimer:Ub-p-PEX5
See in Reactome
|
MONDO:0008869 |
ATR |
Q13535 |
2.7.11.1
|
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-69473
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-1221632
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
R-HSA-6783310
R-HSA-176187
R-HSA-176187
Reactome Name: Activation of ATR in response to replication stress
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-8953897
R-HSA-5633007
R-HSA-69481
R-HSA-69620
R-HSA-212436
R-HSA-74160
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-2262752
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-1500620
R-HSA-5693538
R-HSA-1640170
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-1474165
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-73857
|
Cellular responses to stimuli
Gene expression (Transcription)
Cell Cycle
DNA Repair
Reproduction
|
R-HSA-176116
(
R-HSA-176187;
R-HSA-69473
)
R-HSA-176116
Reaction Name: Recruitment and activation of Chk1
See in Reactome
R-HSA-176250
(
R-HSA-176187
)
R-HSA-176250
Reaction Name: Binding of ATR-ATRIP to the RPA-ssDNA complex
See in Reactome
R-HSA-176298
(
R-HSA-176187
)
R-HSA-3371567
(
R-HSA-3371453
)
R-HSA-3371567
Reaction Name: DBC1 is phosphorylated by ATM/ART
See in Reactome
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5693561
(
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-6788385
(
R-HSA-6783310
)
R-HSA-6788385
Reaction Name: The complex of ATR and ATRIP is recruited to ICL-DNA
See in Reactome
R-HSA-6788392
(
R-HSA-6783310
)
R-HSA-6788392
Reaction Name: ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-912450
(
R-HSA-1221632
)
R-HSA-912450
Reaction Name: ATR Kinase is recruited to unsynapsed regions
See in Reactome
R-HSA-912470
(
R-HSA-1221632
)
R-HSA-912470
Reaction Name: ATR phosphorylates Histone H2A.X at unsynapsed regions
See in Reactome
|
MONDO:0009327 |
MAPK1 |
P28482 |
2.7.11.24
|
R-HSA-2559585
R-HSA-445144
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-111995
R-HSA-2559580
R-HSA-2559580
Reactome Name: Oxidative Stress Induced Senescence
See in Reactome
R-HSA-198753
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-8940973
R-HSA-8940973
Reactome Name: RUNX2 regulates osteoblast differentiation
See in Reactome
R-HSA-170968
R-HSA-437239
R-HSA-444257
R-HSA-6798695
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-1181150
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-982772
R-HSA-982772
Reactome Name: Growth hormone receptor signaling
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-2559582
R-HSA-2559582
Reactome Name: Senescence-Associated Secretory Phenotype (SASP)
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-5673001
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-2173796
R-HSA-2173796
Reactome Name: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
See in Reactome
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
R-HSA-1502540
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-450341
R-HSA-450341
Reactome Name: Activation of the AP-1 family of transcription factors
See in Reactome
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-74749
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-8939211
R-HSA-5674135
R-HSA-202670
R-HSA-879415
R-HSA-879415
Reactome Name: Advanced glycosylation endproduct receptor signaling
See in Reactome
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-162658
R-HSA-162658
Reactome Name: Golgi Cisternae Pericentriolar Stack Reorganization
See in Reactome
R-HSA-456926
R-HSA-456926
Reactome Name: Thrombin signalling through proteinase activated receptors (PARs)
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-112411
R-HSA-9627069
R-HSA-9627069
Reactome Name: Regulation of the apoptosome activity
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-111996
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-1640170
R-HSA-1266738
R-HSA-73857
R-HSA-212436
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-2262752
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-112316
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-373760
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-450294
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-416476
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-111471
R-HSA-111471
Reactome Name: Apoptotic factor-mediated response
See in Reactome
R-HSA-168256
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-450282
R-HSA-450282
Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases
See in Reactome
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-111461
R-HSA-111461
Reactome Name: Cytochrome c-mediated apoptotic response
See in Reactome
R-HSA-69278
R-HSA-198725
R-HSA-198725
Reactome Name: Nuclear Events (kinase and transcription factor activation)
See in Reactome
R-HSA-166166
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-168249
R-HSA-68886
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-187037
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-112043
R-HSA-112040
R-HSA-5654738
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-422475
R-HSA-68875
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-2559583
R-HSA-8941326
R-HSA-8941326
Reactome Name: RUNX2 regulates bone development
See in Reactome
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-5357801
R-HSA-74752
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-74160
R-HSA-168898
R-HSA-2173793
R-HSA-2173793
Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-8953897
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-111885
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-187687
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
R-HSA-449147
R-HSA-418594
R-HSA-194315
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-5684996
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-5654743
R-HSA-5654741
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-190236
R-HSA-388396
R-HSA-5654736
R-HSA-195258
R-HSA-1257604
R-HSA-372790
R-HSA-6807070
R-HSA-448424
R-HSA-109581
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-111458
R-HSA-109582
R-HSA-162582
|
Cell Cycle
Developmental Biology
Neuronal System
Immune System
Programmed Cell Death
Gene expression (Transcription)
Cellular responses to stimuli
Hemostasis
Signal Transduction
|
R-HSA-109822
(
R-HSA-74749
)
R-HSA-109822
Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1
See in Reactome
R-HSA-109823
(
R-HSA-74749
)
R-HSA-109823
Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2
See in Reactome
R-HSA-109858
(
R-HSA-112409;
R-HSA-112411
)
R-HSA-109862
(
R-HSA-112409;
R-HSA-112411;
R-HSA-445144
)
R-HSA-109864
(
R-HSA-112409;
R-HSA-112411
)
R-HSA-109864
Reaction Name: Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2
See in Reactome
R-HSA-111898
(
R-HSA-111995
)
R-HSA-111898
Reaction Name: Phosphorylation of cPLA2 by ERK-2
See in Reactome
R-HSA-1168459
(
R-HSA-982772
)
R-HSA-1295634
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-168053
(
R-HSA-450341
)
R-HSA-168053
Reaction Name: Phosphorylated MAPKs phosphorylate ATF-2
See in Reactome
R-HSA-173488
(
R-HSA-1181150;
R-HSA-1502540;
R-HSA-2173796
)
R-HSA-173488
Reaction Name: The SMAD2/3:SMAD4 complex transfers to the nucleus
See in Reactome
R-HSA-198731
(
R-HSA-198753;
R-HSA-8939211;
R-HSA-9634638
)
R-HSA-198746
(
R-HSA-198753;
R-HSA-2559582;
R-HSA-881907
)
R-HSA-198756
(
R-HSA-198753;
R-HSA-375165
)
R-HSA-199959
(
R-HSA-198753;
R-HSA-202670
)
R-HSA-199959
Reaction Name: ERKs are inactivated by protein phosphatase 2A
See in Reactome
R-HSA-2029469
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029469
Reaction Name: p-ERK phosphorylates WAVEs and ABI
See in Reactome
R-HSA-203797
(
R-HSA-198753;
R-HSA-202670
)
R-HSA-203797
Reaction Name: ERKs are inactivated by dual-specific phosphatases (DUSPs)
See in Reactome
R-HSA-2422927
(
R-HSA-162658
)
R-HSA-2422927
Reaction Name: MAPK3-3 or MAPK1 phosphorylate GORASP2
See in Reactome
R-HSA-3132737
(
R-HSA-2559585
)
R-HSA-3132737
Reaction Name: MAPKs phosphorylate ETS1 and ETS2
See in Reactome
R-HSA-3209160
(
R-HSA-2559585
)
R-HSA-3209160
Reaction Name: Activated ERKs phosphorylate ERF
See in Reactome
R-HSA-3209177
(
R-HSA-2559585
)
R-HSA-3223236
(
R-HSA-2559580
)
R-HSA-3223236
Reaction Name: RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS)
See in Reactome
R-HSA-3371531
(
R-HSA-3371453
)
R-HSA-3371531
Reaction Name: Constitutive phosphorylation by pERK1/2
See in Reactome
R-HSA-3857329
(
R-HSA-2559582
)
R-HSA-3857329
Reaction Name: MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB
See in Reactome
R-HSA-418158
(
R-HSA-456926
)
R-HSA-418158
Reaction Name: SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1)
See in Reactome
R-HSA-418163
(
R-HSA-456926
)
R-HSA-418163
Reaction Name: Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)
See in Reactome
R-HSA-418170
(
R-HSA-456926
)
R-HSA-418176
(
R-HSA-456926
)
R-HSA-418200
(
R-HSA-456926
)
R-HSA-418200
Reaction Name: SRC-1 bound to ARRB2 is not activated
See in Reactome
R-HSA-445079
(
R-HSA-437239
)
R-HSA-450325
(
R-HSA-2559580;
R-HSA-2871796;
R-HSA-450341
)
R-HSA-450325
Reaction Name: c-FOS activation by phospho ERK1/2
See in Reactome
R-HSA-5654560
(
R-HSA-5654726
)
R-HSA-5654560
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2.
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654565
(
R-HSA-5654732
)
R-HSA-5654565
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2.
See in Reactome
R-HSA-5654566
(
R-HSA-5654733
)
R-HSA-5654566
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2.
See in Reactome
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674366
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674366
Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs
See in Reactome
R-HSA-5674373
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674373
Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane
See in Reactome
R-HSA-5674385
(
R-HSA-112409;
R-HSA-170968;
R-HSA-5673001
)
R-HSA-5674387
(
R-HSA-112409;
R-HSA-5673001
)
R-HSA-5674387
Reaction Name: Phosphorylated MAPKs translocate into the nucleus
See in Reactome
R-HSA-5674496
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5674496
Reaction Name: Activated MAPKs phosphorylate MAP2K1
See in Reactome
R-HSA-5675194
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675194
Reaction Name: Activated MAPK phosphorylates RAF1
See in Reactome
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675206
(
R-HSA-112409;
R-HSA-5673001
)
R-HSA-5675206
Reaction Name: PEA15 binds MAPK monomers and dimers
See in Reactome
R-HSA-5675373
(
R-HSA-112409;
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675373
Reaction Name: Nuclear DUSPs dephosphorylate MAPKs
See in Reactome
R-HSA-5675376
(
R-HSA-112409;
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675376
Reaction Name: Cytosolic DUSPs dephosphorylate MAPKs
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-6811454
(
R-HSA-6811558
)
R-HSA-6811472
(
R-HSA-6811558
)
R-HSA-6811472
Reaction Name: IER3 recruits MAPKs to PP2A-B56-beta,gamma
See in Reactome
R-HSA-879362
(
R-HSA-879415
)
R-HSA-8944047
(
R-HSA-8943724
)
R-HSA-8944047
Reaction Name: JUN binds the PTEN gene promoter
See in Reactome
R-HSA-9009208
(
R-HSA-8940973
)
R-HSA-9009208
Reaction Name: Activated ERKs phosphorylate RUNX2
See in Reactome
R-HSA-9032751
(
R-HSA-8939211
)
R-HSA-9032751
Reaction Name: Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610166
(
R-HSA-170968
)
R-HSA-9610166
Reaction Name: p-T,Y MAPK dimers translocate to nucleus
See in Reactome
R-HSA-9619843
(
R-HSA-444257
)
R-HSA-9626832
(
R-HSA-5668599
)
R-HSA-9626832
Reaction Name: MAPK1 or MAPK3 phosphorylates NCF1 at Ser345
See in Reactome
R-HSA-9627089
(
R-HSA-9627069
)
R-HSA-9627089
Reaction Name: CASP9 is phosphorylated at T125
See in Reactome
R-HSA-9632873
(
R-HSA-8939211;
R-HSA-9634638
)
R-HSA-9632873
Reaction Name: p-S10 CDKN1B translocates to the cytosol
See in Reactome
R-HSA-9632910
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9635739
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-9635739
Reaction Name: PTPN7 dephosphorylates p-T,Y-MAPKs
See in Reactome
R-HSA-9635743
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
|
MONDO:0011953 |
RANBP2 |
P49792 |
2.3.2.-
|
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-170822
R-HSA-170822
Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein
See in Reactome
R-HSA-1169408
R-HSA-4615885
R-HSA-4615885
Reactome Name: SUMOylation of DNA replication proteins
See in Reactome
R-HSA-2500257
R-HSA-2500257
Reactome Name: Resolution of Sister Chromatid Cohesion
See in Reactome
R-HSA-159230
R-HSA-159230
Reactome Name: Transport of the SLBP Dependant Mature mRNA
See in Reactome
R-HSA-159231
R-HSA-159231
Reactome Name: Transport of Mature mRNA Derived from an Intronless Transcript
See in Reactome
R-HSA-9648025
R-HSA-9648025
Reactome Name: EML4 and NUDC in mitotic spindle formation
See in Reactome
R-HSA-3232142
R-HSA-3232142
Reactome Name: SUMOylation of ubiquitinylation proteins
See in Reactome
R-HSA-4085377
R-HSA-4085377
Reactome Name: SUMOylation of SUMOylation proteins
See in Reactome
R-HSA-159236
R-HSA-159236
Reactome Name: Transport of Mature mRNA derived from an Intron-Containing Transcript
See in Reactome
R-HSA-4551638
R-HSA-4551638
Reactome Name: SUMOylation of chromatin organization proteins
See in Reactome
R-HSA-141444
R-HSA-141444
Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
See in Reactome
R-HSA-5663220
R-HSA-191859
R-HSA-159227
R-HSA-159227
Reactome Name: Transport of the SLBP independent Mature mRNA
See in Reactome
R-HSA-6784531
R-HSA-6784531
Reactome Name: tRNA processing in the nucleus
See in Reactome
R-HSA-4570464
R-HSA-4570464
Reactome Name: SUMOylation of RNA binding proteins
See in Reactome
R-HSA-3108214
R-HSA-3108214
Reactome Name: SUMOylation of DNA damage response and repair proteins
See in Reactome
R-HSA-5578749
R-HSA-5578749
Reactome Name: Transcriptional regulation by small RNAs
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
R-HSA-68877
R-HSA-3301854
R-HSA-3301854
Reactome Name: Nuclear Pore Complex (NPC) Disassembly
See in Reactome
|
R-HSA-70326
R-HSA-168256
R-HSA-194315
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-1430728
R-HSA-72203
R-HSA-72203
Reactome Name: Processing of Capped Intron-Containing Pre-mRNA
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1640170
R-HSA-72306
R-HSA-194441
R-HSA-71387
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-74160
R-HSA-159234
R-HSA-159234
Reactome Name: Transport of Mature mRNAs Derived from Intronless Transcripts
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-69278
R-HSA-2990846
R-HSA-913531
R-HSA-211000
R-HSA-8953897
R-HSA-141424
R-HSA-141424
Reactome Name: Amplification of signal from the kinetochores
See in Reactome
R-HSA-8953854
R-HSA-392499
R-HSA-68886
R-HSA-70171
R-HSA-68882
R-HSA-1169410
R-HSA-1169410
Reactome Name: Antiviral mechanism by IFN-stimulated genes
See in Reactome
R-HSA-195258
R-HSA-3108232
R-HSA-3108232
Reactome Name: SUMO E3 ligases SUMOylate target proteins
See in Reactome
R-HSA-2980766
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-72202
R-HSA-72202
Reactome Name: Transport of Mature Transcript to Cytoplasm
See in Reactome
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-69618
R-HSA-162582
R-HSA-68875
|
Immune System
Metabolism
Cell Cycle
Gene expression (Transcription)
Cellular responses to stimuli
Metabolism of RNA
Metabolism of proteins
Signal Transduction
|
R-HSA-111439
(
R-HSA-159227
)
R-HSA-111439
Reaction Name: Docking of Mature Histone mRNA complex:TAP at the NPC
See in Reactome
R-HSA-1176059
(
R-HSA-1169408
)
R-HSA-1176059
Reaction Name: Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus
See in Reactome
R-HSA-141409
(
R-HSA-141444
)
R-HSA-141422
(
R-HSA-141444
)
R-HSA-141422
Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1
See in Reactome
R-HSA-141431
(
R-HSA-141444
)
R-HSA-141431
Reaction Name: MAD2 associates with the Mad1 kinetochore complex
See in Reactome
R-HSA-141439
(
R-HSA-141444
)
R-HSA-141439
Reaction Name: Release of activated MAD2 from kinetochores
See in Reactome
R-HSA-158441
(
R-HSA-159231
)
R-HSA-158441
Reaction Name: Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC
See in Reactome
R-HSA-158447
(
R-HSA-159231
)
R-HSA-158447
Reaction Name: Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC
See in Reactome
R-HSA-158481
(
R-HSA-159227
)
R-HSA-158481
Reaction Name: Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC
See in Reactome
R-HSA-158484
(
R-HSA-159227
)
R-HSA-158484
Reaction Name: Release of the SLBP independent Histone mRNA from the NPC
See in Reactome
R-HSA-159046
(
R-HSA-159230
)
R-HSA-159046
Reaction Name: Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC
See in Reactome
R-HSA-159050
(
R-HSA-159230
)
R-HSA-159050
Reaction Name: Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex
See in Reactome
R-HSA-1638803
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638803
Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres
See in Reactome
R-HSA-1638821
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-1638821
Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin
See in Reactome
R-HSA-170796
(
R-HSA-170822
)
R-HSA-170796
Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm
See in Reactome
R-HSA-191825
(
R-HSA-191859
)
R-HSA-191825
Reaction Name: Nuclear export of snRNA transcripts
See in Reactome
R-HSA-191830
(
R-HSA-191859
)
R-HSA-191830
Reaction Name: snRNP nuclear import and release
See in Reactome
R-HSA-2467809
(
R-HSA-2467813
)
R-HSA-2467809
Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin
See in Reactome
R-HSA-2467811
(
R-HSA-2467813
)
R-HSA-2467811
Reaction Name: Separation of sister chromatids
See in Reactome
R-HSA-2468287
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-2468287
Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres
See in Reactome
R-HSA-2484822
(
R-HSA-2500257;
R-HSA-68877
)
R-HSA-2990880
(
R-HSA-3301854
)
R-HSA-2990880
Reaction Name: NEK6/NEK7 phosphorylates NUP98
See in Reactome
R-HSA-2990882
(
R-HSA-3301854
)
R-HSA-3000348
(
R-HSA-3108214
)
R-HSA-3000348
Reaction Name: RANBP2 SUMOylates SP100 with SUMO2
See in Reactome
R-HSA-3000399
(
R-HSA-3108214
)
R-HSA-3000399
Reaction Name: RANBP2 SUMOylates SP100 with SUMO1
See in Reactome
R-HSA-3000411
(
R-HSA-3108214
)
R-HSA-3000411
Reaction Name: RANBP2 SUMOylates PML with SUMO2
See in Reactome
R-HSA-375302
(
R-HSA-68877
)
R-HSA-375302
Reaction Name: Kinetochore capture of astral microtubules
See in Reactome
R-HSA-4551649
(
R-HSA-4085377
)
R-HSA-4551649
Reaction Name: RANBP2 SUMOylates RANBP2 with SUMO1
See in Reactome
R-HSA-4551679
(
R-HSA-4085377
)
R-HSA-4551679
Reaction Name: RANBP2 SUMOylates RANBP2 with SUMO2
See in Reactome
R-HSA-4570493
(
R-HSA-4570464
)
R-HSA-4570493
Reaction Name: RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1
See in Reactome
R-HSA-4615872
(
R-HSA-4551638
)
R-HSA-4615872
Reaction Name: RANBP2 SUMOylates HDAC4 with SUMO1
See in Reactome
R-HSA-4615987
(
R-HSA-4551638
)
R-HSA-4615987
Reaction Name: RANBP2 SUMOylates HDAC4 with SUMO2,3
See in Reactome
R-HSA-4655355
(
R-HSA-4615885
)
R-HSA-4655355
Reaction Name: RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)
See in Reactome
R-HSA-5228508
(
R-HSA-3108214
)
R-HSA-5228508
Reaction Name: RANBP2 SUMOylates PML with SUMO1
See in Reactome
R-HSA-5228523
(
R-HSA-3232142
)
R-HSA-5228523
Reaction Name: RANBP2 SUMOylates MDM2 with SUMO1
See in Reactome
R-HSA-5228525
(
R-HSA-4615885
)
R-HSA-5228525
Reaction Name: RANBP2 SUMOylates TOP2A with SUMO1
See in Reactome
R-HSA-5252041
(
R-HSA-3371453
)
R-HSA-5252041
Reaction Name: NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm
See in Reactome
R-HSA-5578744
(
R-HSA-5578749
)
R-HSA-5578744
Reaction Name: Importin-8 imports AGO2:miRNA into the nucleus
See in Reactome
R-HSA-5666129
(
R-HSA-5663220
)
R-HSA-5666129
Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores
See in Reactome
R-HSA-5666160
(
R-HSA-5663220
)
R-HSA-5666160
Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores
See in Reactome
R-HSA-5666169
(
R-HSA-5663220
)
R-HSA-5666169
Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
See in Reactome
R-HSA-6783483
(
R-HSA-6784531
)
R-HSA-6783483
Reaction Name: tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol
See in Reactome
R-HSA-75096
(
R-HSA-159236
)
R-HSA-75096
Reaction Name: Docking of the TAP:EJC Complex with the NPC
See in Reactome
R-HSA-75097
(
R-HSA-159236
)
R-HSA-75097
Reaction Name: Transport of the export-competent mRNP complex through the NPC
See in Reactome
R-HSA-75098
(
R-HSA-159236
)
R-HSA-75098
Reaction Name: mRNP complex dissociates from cytosolic face of NPC
See in Reactome
R-HSA-77587
(
R-HSA-159230
)
R-HSA-77587
Reaction Name: Docking of Mature Replication Dependent Histone mRNA with the NPC
See in Reactome
R-HSA-77594
(
R-HSA-159231
)
R-HSA-77594
Reaction Name: Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC
See in Reactome
R-HSA-9648114
(
R-HSA-68877;
R-HSA-9648025
)
R-HSA-9648114
Reaction Name: EML4 recruits NUDC to mitotic spindle
See in Reactome
|
MONDO:0013806 |
ATR |
Q13535 |
2.7.11.1
|
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-69473
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-1221632
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
R-HSA-6783310
R-HSA-176187
R-HSA-176187
Reactome Name: Activation of ATR in response to replication stress
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-8953897
R-HSA-5633007
R-HSA-69481
R-HSA-69620
R-HSA-212436
R-HSA-74160
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-2262752
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-1500620
R-HSA-5693538
R-HSA-1640170
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-1474165
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-73857
|
Cellular responses to stimuli
Gene expression (Transcription)
Cell Cycle
DNA Repair
Reproduction
|
R-HSA-176116
(
R-HSA-176187;
R-HSA-69473
)
R-HSA-176116
Reaction Name: Recruitment and activation of Chk1
See in Reactome
R-HSA-176250
(
R-HSA-176187
)
R-HSA-176250
Reaction Name: Binding of ATR-ATRIP to the RPA-ssDNA complex
See in Reactome
R-HSA-176298
(
R-HSA-176187
)
R-HSA-3371567
(
R-HSA-3371453
)
R-HSA-3371567
Reaction Name: DBC1 is phosphorylated by ATM/ART
See in Reactome
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5693561
(
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-6788385
(
R-HSA-6783310
)
R-HSA-6788385
Reaction Name: The complex of ATR and ATRIP is recruited to ICL-DNA
See in Reactome
R-HSA-6788392
(
R-HSA-6783310
)
R-HSA-6788392
Reaction Name: ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-912450
(
R-HSA-1221632
)
R-HSA-912450
Reaction Name: ATR Kinase is recruited to unsynapsed regions
See in Reactome
R-HSA-912470
(
R-HSA-1221632
)
R-HSA-912470
Reaction Name: ATR phosphorylates Histone H2A.X at unsynapsed regions
See in Reactome
|
MONDO:0015356 |
ATM |
Q13315 |
2.7.11.1
|
R-HSA-2559586
R-HSA-2559586
Reactome Name: DNA Damage/Telomere Stress Induced Senescence
See in Reactome
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-9664873
R-HSA-69473
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-69541
R-HSA-6803207
R-HSA-6803207
Reactome Name: TP53 Regulates Transcription of Caspase Activators and Caspases
See in Reactome
R-HSA-6803204
R-HSA-6803204
Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5693548
R-HSA-5693548
Reactome Name: Sensing of DNA Double Strand Breaks
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-912446
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-2559583
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-1640170
R-HSA-8953897
R-HSA-73857
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-5633007
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-5633008
R-HSA-5633008
Reactome Name: TP53 Regulates Transcription of Cell Death Genes
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-5693538
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-1474165
R-HSA-9612973
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-9663891
R-HSA-1632852
R-HSA-69481
R-HSA-69615
R-HSA-1500620
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
|
Cell Cycle
Cellular responses to stimuli
Gene expression (Transcription)
Reproduction
Autophagy
DNA Repair
|
R-HSA-3371567
(
R-HSA-3371453
)
R-HSA-3371567
Reaction Name: DBC1 is phosphorylated by ATM/ART
See in Reactome
R-HSA-349444
(
R-HSA-349425;
R-HSA-69541
)
R-HSA-349444
Reaction Name: Phosphorylation of COP1 at Ser-387 by ATM
See in Reactome
R-HSA-349455
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-5682018
(
R-HSA-2559586
)
R-HSA-5682018
Reaction Name: MRN complex bound to shortened telomeres recruits ATM
See in Reactome
R-HSA-5682026
(
R-HSA-2559586
)
R-HSA-5682026
Reaction Name: MRN bound to shortened telomeres activates ATM
See in Reactome
R-HSA-5682044
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5682044
Reaction Name: KAT5 acetylates ATM at DNA DSBs
See in Reactome
R-HSA-5682586
(
R-HSA-5693565
)
R-HSA-5682586
Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs
See in Reactome
R-HSA-5682588
(
R-HSA-5693565
)
R-HSA-5682588
Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs
See in Reactome
R-HSA-5682598
(
R-HSA-5693565
)
R-HSA-5682607
(
R-HSA-5693565
)
R-HSA-5682607
Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
See in Reactome
R-HSA-5682629
(
R-HSA-5693565
)
R-HSA-5682629
Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
See in Reactome
R-HSA-5682858
(
R-HSA-5693565
)
R-HSA-5682858
Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX
See in Reactome
R-HSA-5682863
(
R-HSA-5693565
)
R-HSA-5682965
(
R-HSA-5693565
)
R-HSA-5682965
Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs
See in Reactome
R-HSA-5682967
(
R-HSA-5693565
)
R-HSA-5682983
(
R-HSA-5693565
)
R-HSA-5682992
(
R-HSA-5693565
)
R-HSA-5683077
(
R-HSA-5693565
)
R-HSA-5683077
Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B
See in Reactome
R-HSA-5683384
(
R-HSA-5693565
)
R-HSA-5683384
Reaction Name: UIMC1 and FAM175A bind DNA DSBs
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683405
(
R-HSA-5693565
)
R-HSA-5683405
Reaction Name: PPP5C dephosphorylates TP53BP1
See in Reactome
R-HSA-5683425
(
R-HSA-5693565
)
R-HSA-5683425
Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
R-HSA-5683986
(
R-HSA-5693565
)
R-HSA-5683986
Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX
See in Reactome
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684081
(
R-HSA-5693607
)
R-HSA-5684081
Reaction Name: MRN complex binds CDK2 and RBBP8
See in Reactome
R-HSA-5684096
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684140
(
R-HSA-5693607
)
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686578
(
R-HSA-5693565
)
R-HSA-5686578
Reaction Name: Activated ATM phosphorylates ABL1
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5686704
(
R-HSA-5693571
)
R-HSA-5686704
Reaction Name: Activated ATM phosphorylates DCLRE1C
See in Reactome
R-HSA-5686900
(
R-HSA-5693571
)
R-HSA-5686900
Reaction Name: TP53BP1 recruits DCLRE1C to ATM
See in Reactome
R-HSA-5693536
(
R-HSA-5693565
)
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693540
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693549
(
R-HSA-5693565
)
R-HSA-5693549
Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693566
(
R-HSA-5693565
)
R-HSA-5693566
Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693583
(
R-HSA-5693565
)
R-HSA-5693583
Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693598
(
R-HSA-5693565
)
R-HSA-5693599
(
R-HSA-5693571
)
R-HSA-5693599
Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break
See in Reactome
R-HSA-5693602
(
R-HSA-5693565
)
R-HSA-5693602
Reaction Name: ATM recognizes H2AFX-Nucleosomes
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693609
(
R-HSA-2559586;
R-HSA-5693565;
R-HSA-6804756;
R-HSA-69541
)
R-HSA-5693609
Reaction Name: ATM phosphorylates TP53 at S15
See in Reactome
R-HSA-5693612
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693612
Reaction Name: MRN complex bound to DNA ends recruits ATM
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6792712
(
R-HSA-2559586
)
R-HSA-6792712
Reaction Name: KAT5 acetylates ATM at shortened telomeres
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6798372
(
R-HSA-6804756
)
R-HSA-6799097
(
R-HSA-6803204
)
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-6800490
(
R-HSA-6803207
)
R-HSA-6804276
(
R-HSA-6804760
)
R-HSA-6804741
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-6804741
Reaction Name: MDM2 forms homo- or heterodimers
See in Reactome
R-HSA-6804955
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-912429
(
R-HSA-912446
)
R-HSA-912429
Reaction Name: Resolution of meiotic holliday junction
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912496
(
R-HSA-912446
)
R-HSA-912496
Reaction Name: Formation of meiotic holliday junction
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9664850
(
R-HSA-9664873
)
R-HSA-9664855
(
R-HSA-9664873
)
R-HSA-9664855
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664862
(
R-HSA-9664873
)
R-HSA-9664862
Reaction Name: ATM dimer:PEX5 phosphorylates PEX5
See in Reactome
R-HSA-9664879
(
R-HSA-9664873
)
R-HSA-9664880
(
R-HSA-9664873
)
R-HSA-9664880
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1
See in Reactome
R-HSA-9664881
(
R-HSA-9664873
)
R-HSA-9664881
Reaction Name: NBR1 binds ATM:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664883
(
R-HSA-9664873
)
R-HSA-9664883
Reaction Name: ATM:PEX5 translocates from cytosol to peroxisomal membrane
See in Reactome
R-HSA-9664888
(
R-HSA-9664873
)
R-HSA-9664888
Reaction Name: ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9664892
(
R-HSA-9664873
)
R-HSA-9664892
Reaction Name: SQSTM1 binds ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674127
(
R-HSA-9664873
)
R-HSA-9674127
Reaction Name: USP30 deubiquitinates ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674131
(
R-HSA-9664873
)
R-HSA-9674131
Reaction Name: USP30 binds ATM dimer:Ub-p-PEX5
See in Reactome
|
MONDO:0016225 |
MAPK1 |
P28482 |
2.7.11.24
|
R-HSA-2559585
R-HSA-445144
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-111995
R-HSA-2559580
R-HSA-2559580
Reactome Name: Oxidative Stress Induced Senescence
See in Reactome
R-HSA-198753
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-8940973
R-HSA-8940973
Reactome Name: RUNX2 regulates osteoblast differentiation
See in Reactome
R-HSA-170968
R-HSA-437239
R-HSA-444257
R-HSA-6798695
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-1181150
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-982772
R-HSA-982772
Reactome Name: Growth hormone receptor signaling
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-2559582
R-HSA-2559582
Reactome Name: Senescence-Associated Secretory Phenotype (SASP)
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-5673001
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-2173796
R-HSA-2173796
Reactome Name: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
See in Reactome
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
R-HSA-1502540
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-450341
R-HSA-450341
Reactome Name: Activation of the AP-1 family of transcription factors
See in Reactome
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-74749
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-8939211
R-HSA-5674135
R-HSA-202670
R-HSA-879415
R-HSA-879415
Reactome Name: Advanced glycosylation endproduct receptor signaling
See in Reactome
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-162658
R-HSA-162658
Reactome Name: Golgi Cisternae Pericentriolar Stack Reorganization
See in Reactome
R-HSA-456926
R-HSA-456926
Reactome Name: Thrombin signalling through proteinase activated receptors (PARs)
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-112411
R-HSA-9627069
R-HSA-9627069
Reactome Name: Regulation of the apoptosome activity
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-111996
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-1640170
R-HSA-1266738
R-HSA-73857
R-HSA-212436
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-2262752
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-112316
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-373760
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-450294
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-416476
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-111471
R-HSA-111471
Reactome Name: Apoptotic factor-mediated response
See in Reactome
R-HSA-168256
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-450282
R-HSA-450282
Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases
See in Reactome
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-111461
R-HSA-111461
Reactome Name: Cytochrome c-mediated apoptotic response
See in Reactome
R-HSA-69278
R-HSA-198725
R-HSA-198725
Reactome Name: Nuclear Events (kinase and transcription factor activation)
See in Reactome
R-HSA-166166
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-168249
R-HSA-68886
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-187037
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-112043
R-HSA-112040
R-HSA-5654738
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-422475
R-HSA-68875
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-2559583
R-HSA-8941326
R-HSA-8941326
Reactome Name: RUNX2 regulates bone development
See in Reactome
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-5357801
R-HSA-74752
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-74160
R-HSA-168898
R-HSA-2173793
R-HSA-2173793
Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-8953897
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-111885
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-187687
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
R-HSA-449147
R-HSA-418594
R-HSA-194315
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-5684996
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-5654743
R-HSA-5654741
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-190236
R-HSA-388396
R-HSA-5654736
R-HSA-195258
R-HSA-1257604
R-HSA-372790
R-HSA-6807070
R-HSA-448424
R-HSA-109581
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-111458
R-HSA-109582
R-HSA-162582
|
Cell Cycle
Developmental Biology
Neuronal System
Immune System
Programmed Cell Death
Gene expression (Transcription)
Cellular responses to stimuli
Hemostasis
Signal Transduction
|
R-HSA-109822
(
R-HSA-74749
)
R-HSA-109822
Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1
See in Reactome
R-HSA-109823
(
R-HSA-74749
)
R-HSA-109823
Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2
See in Reactome
R-HSA-109858
(
R-HSA-112409;
R-HSA-112411
)
R-HSA-109862
(
R-HSA-112409;
R-HSA-112411;
R-HSA-445144
)
R-HSA-109864
(
R-HSA-112409;
R-HSA-112411
)
R-HSA-109864
Reaction Name: Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2
See in Reactome
R-HSA-111898
(
R-HSA-111995
)
R-HSA-111898
Reaction Name: Phosphorylation of cPLA2 by ERK-2
See in Reactome
R-HSA-1168459
(
R-HSA-982772
)
R-HSA-1295634
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-168053
(
R-HSA-450341
)
R-HSA-168053
Reaction Name: Phosphorylated MAPKs phosphorylate ATF-2
See in Reactome
R-HSA-173488
(
R-HSA-1181150;
R-HSA-1502540;
R-HSA-2173796
)
R-HSA-173488
Reaction Name: The SMAD2/3:SMAD4 complex transfers to the nucleus
See in Reactome
R-HSA-198731
(
R-HSA-198753;
R-HSA-8939211;
R-HSA-9634638
)
R-HSA-198746
(
R-HSA-198753;
R-HSA-2559582;
R-HSA-881907
)
R-HSA-198756
(
R-HSA-198753;
R-HSA-375165
)
R-HSA-199959
(
R-HSA-198753;
R-HSA-202670
)
R-HSA-199959
Reaction Name: ERKs are inactivated by protein phosphatase 2A
See in Reactome
R-HSA-2029469
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029469
Reaction Name: p-ERK phosphorylates WAVEs and ABI
See in Reactome
R-HSA-203797
(
R-HSA-198753;
R-HSA-202670
)
R-HSA-203797
Reaction Name: ERKs are inactivated by dual-specific phosphatases (DUSPs)
See in Reactome
R-HSA-2422927
(
R-HSA-162658
)
R-HSA-2422927
Reaction Name: MAPK3-3 or MAPK1 phosphorylate GORASP2
See in Reactome
R-HSA-3132737
(
R-HSA-2559585
)
R-HSA-3132737
Reaction Name: MAPKs phosphorylate ETS1 and ETS2
See in Reactome
R-HSA-3209160
(
R-HSA-2559585
)
R-HSA-3209160
Reaction Name: Activated ERKs phosphorylate ERF
See in Reactome
R-HSA-3209177
(
R-HSA-2559585
)
R-HSA-3223236
(
R-HSA-2559580
)
R-HSA-3223236
Reaction Name: RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS)
See in Reactome
R-HSA-3371531
(
R-HSA-3371453
)
R-HSA-3371531
Reaction Name: Constitutive phosphorylation by pERK1/2
See in Reactome
R-HSA-3857329
(
R-HSA-2559582
)
R-HSA-3857329
Reaction Name: MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB
See in Reactome
R-HSA-418158
(
R-HSA-456926
)
R-HSA-418158
Reaction Name: SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1)
See in Reactome
R-HSA-418163
(
R-HSA-456926
)
R-HSA-418163
Reaction Name: Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)
See in Reactome
R-HSA-418170
(
R-HSA-456926
)
R-HSA-418176
(
R-HSA-456926
)
R-HSA-418200
(
R-HSA-456926
)
R-HSA-418200
Reaction Name: SRC-1 bound to ARRB2 is not activated
See in Reactome
R-HSA-445079
(
R-HSA-437239
)
R-HSA-450325
(
R-HSA-2559580;
R-HSA-2871796;
R-HSA-450341
)
R-HSA-450325
Reaction Name: c-FOS activation by phospho ERK1/2
See in Reactome
R-HSA-5654560
(
R-HSA-5654726
)
R-HSA-5654560
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2.
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654565
(
R-HSA-5654732
)
R-HSA-5654565
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2.
See in Reactome
R-HSA-5654566
(
R-HSA-5654733
)
R-HSA-5654566
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2.
See in Reactome
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674366
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674366
Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs
See in Reactome
R-HSA-5674373
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674373
Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane
See in Reactome
R-HSA-5674385
(
R-HSA-112409;
R-HSA-170968;
R-HSA-5673001
)
R-HSA-5674387
(
R-HSA-112409;
R-HSA-5673001
)
R-HSA-5674387
Reaction Name: Phosphorylated MAPKs translocate into the nucleus
See in Reactome
R-HSA-5674496
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5674496
Reaction Name: Activated MAPKs phosphorylate MAP2K1
See in Reactome
R-HSA-5675194
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675194
Reaction Name: Activated MAPK phosphorylates RAF1
See in Reactome
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675206
(
R-HSA-112409;
R-HSA-5673001
)
R-HSA-5675206
Reaction Name: PEA15 binds MAPK monomers and dimers
See in Reactome
R-HSA-5675373
(
R-HSA-112409;
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675373
Reaction Name: Nuclear DUSPs dephosphorylate MAPKs
See in Reactome
R-HSA-5675376
(
R-HSA-112409;
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675376
Reaction Name: Cytosolic DUSPs dephosphorylate MAPKs
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-6811454
(
R-HSA-6811558
)
R-HSA-6811472
(
R-HSA-6811558
)
R-HSA-6811472
Reaction Name: IER3 recruits MAPKs to PP2A-B56-beta,gamma
See in Reactome
R-HSA-879362
(
R-HSA-879415
)
R-HSA-8944047
(
R-HSA-8943724
)
R-HSA-8944047
Reaction Name: JUN binds the PTEN gene promoter
See in Reactome
R-HSA-9009208
(
R-HSA-8940973
)
R-HSA-9009208
Reaction Name: Activated ERKs phosphorylate RUNX2
See in Reactome
R-HSA-9032751
(
R-HSA-8939211
)
R-HSA-9032751
Reaction Name: Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610166
(
R-HSA-170968
)
R-HSA-9610166
Reaction Name: p-T,Y MAPK dimers translocate to nucleus
See in Reactome
R-HSA-9619843
(
R-HSA-444257
)
R-HSA-9626832
(
R-HSA-5668599
)
R-HSA-9626832
Reaction Name: MAPK1 or MAPK3 phosphorylates NCF1 at Ser345
See in Reactome
R-HSA-9627089
(
R-HSA-9627069
)
R-HSA-9627089
Reaction Name: CASP9 is phosphorylated at T125
See in Reactome
R-HSA-9632873
(
R-HSA-8939211;
R-HSA-9634638
)
R-HSA-9632873
Reaction Name: p-S10 CDKN1B translocates to the cytosol
See in Reactome
R-HSA-9632910
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9635739
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-9635739
Reaction Name: PTPN7 dephosphorylates p-T,Y-MAPKs
See in Reactome
R-HSA-9635743
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
|
MONDO:0016419 |
ATM |
Q13315 |
2.7.11.1
|
R-HSA-2559586
R-HSA-2559586
Reactome Name: DNA Damage/Telomere Stress Induced Senescence
See in Reactome
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-9664873
R-HSA-69473
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-69541
R-HSA-6803207
R-HSA-6803207
Reactome Name: TP53 Regulates Transcription of Caspase Activators and Caspases
See in Reactome
R-HSA-6803204
R-HSA-6803204
Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5693548
R-HSA-5693548
Reactome Name: Sensing of DNA Double Strand Breaks
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-912446
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-2559583
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-1640170
R-HSA-8953897
R-HSA-73857
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-5633007
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-5633008
R-HSA-5633008
Reactome Name: TP53 Regulates Transcription of Cell Death Genes
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-5693538
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-1474165
R-HSA-9612973
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-9663891
R-HSA-1632852
R-HSA-69481
R-HSA-69615
R-HSA-1500620
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
|
Cell Cycle
Cellular responses to stimuli
Gene expression (Transcription)
Reproduction
Autophagy
DNA Repair
|
R-HSA-3371567
(
R-HSA-3371453
)
R-HSA-3371567
Reaction Name: DBC1 is phosphorylated by ATM/ART
See in Reactome
R-HSA-349444
(
R-HSA-349425;
R-HSA-69541
)
R-HSA-349444
Reaction Name: Phosphorylation of COP1 at Ser-387 by ATM
See in Reactome
R-HSA-349455
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-5682018
(
R-HSA-2559586
)
R-HSA-5682018
Reaction Name: MRN complex bound to shortened telomeres recruits ATM
See in Reactome
R-HSA-5682026
(
R-HSA-2559586
)
R-HSA-5682026
Reaction Name: MRN bound to shortened telomeres activates ATM
See in Reactome
R-HSA-5682044
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5682044
Reaction Name: KAT5 acetylates ATM at DNA DSBs
See in Reactome
R-HSA-5682586
(
R-HSA-5693565
)
R-HSA-5682586
Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs
See in Reactome
R-HSA-5682588
(
R-HSA-5693565
)
R-HSA-5682588
Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs
See in Reactome
R-HSA-5682598
(
R-HSA-5693565
)
R-HSA-5682607
(
R-HSA-5693565
)
R-HSA-5682607
Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
See in Reactome
R-HSA-5682629
(
R-HSA-5693565
)
R-HSA-5682629
Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
See in Reactome
R-HSA-5682858
(
R-HSA-5693565
)
R-HSA-5682858
Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX
See in Reactome
R-HSA-5682863
(
R-HSA-5693565
)
R-HSA-5682965
(
R-HSA-5693565
)
R-HSA-5682965
Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs
See in Reactome
R-HSA-5682967
(
R-HSA-5693565
)
R-HSA-5682983
(
R-HSA-5693565
)
R-HSA-5682992
(
R-HSA-5693565
)
R-HSA-5683077
(
R-HSA-5693565
)
R-HSA-5683077
Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B
See in Reactome
R-HSA-5683384
(
R-HSA-5693565
)
R-HSA-5683384
Reaction Name: UIMC1 and FAM175A bind DNA DSBs
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683405
(
R-HSA-5693565
)
R-HSA-5683405
Reaction Name: PPP5C dephosphorylates TP53BP1
See in Reactome
R-HSA-5683425
(
R-HSA-5693565
)
R-HSA-5683425
Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
R-HSA-5683986
(
R-HSA-5693565
)
R-HSA-5683986
Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX
See in Reactome
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684081
(
R-HSA-5693607
)
R-HSA-5684081
Reaction Name: MRN complex binds CDK2 and RBBP8
See in Reactome
R-HSA-5684096
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684140
(
R-HSA-5693607
)
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686578
(
R-HSA-5693565
)
R-HSA-5686578
Reaction Name: Activated ATM phosphorylates ABL1
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5686704
(
R-HSA-5693571
)
R-HSA-5686704
Reaction Name: Activated ATM phosphorylates DCLRE1C
See in Reactome
R-HSA-5686900
(
R-HSA-5693571
)
R-HSA-5686900
Reaction Name: TP53BP1 recruits DCLRE1C to ATM
See in Reactome
R-HSA-5693536
(
R-HSA-5693565
)
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693540
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693549
(
R-HSA-5693565
)
R-HSA-5693549
Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693566
(
R-HSA-5693565
)
R-HSA-5693566
Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693583
(
R-HSA-5693565
)
R-HSA-5693583
Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693598
(
R-HSA-5693565
)
R-HSA-5693599
(
R-HSA-5693571
)
R-HSA-5693599
Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break
See in Reactome
R-HSA-5693602
(
R-HSA-5693565
)
R-HSA-5693602
Reaction Name: ATM recognizes H2AFX-Nucleosomes
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693609
(
R-HSA-2559586;
R-HSA-5693565;
R-HSA-6804756;
R-HSA-69541
)
R-HSA-5693609
Reaction Name: ATM phosphorylates TP53 at S15
See in Reactome
R-HSA-5693612
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693612
Reaction Name: MRN complex bound to DNA ends recruits ATM
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6792712
(
R-HSA-2559586
)
R-HSA-6792712
Reaction Name: KAT5 acetylates ATM at shortened telomeres
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6798372
(
R-HSA-6804756
)
R-HSA-6799097
(
R-HSA-6803204
)
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-6800490
(
R-HSA-6803207
)
R-HSA-6804276
(
R-HSA-6804760
)
R-HSA-6804741
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-6804741
Reaction Name: MDM2 forms homo- or heterodimers
See in Reactome
R-HSA-6804955
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-912429
(
R-HSA-912446
)
R-HSA-912429
Reaction Name: Resolution of meiotic holliday junction
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912496
(
R-HSA-912446
)
R-HSA-912496
Reaction Name: Formation of meiotic holliday junction
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9664850
(
R-HSA-9664873
)
R-HSA-9664855
(
R-HSA-9664873
)
R-HSA-9664855
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664862
(
R-HSA-9664873
)
R-HSA-9664862
Reaction Name: ATM dimer:PEX5 phosphorylates PEX5
See in Reactome
R-HSA-9664879
(
R-HSA-9664873
)
R-HSA-9664880
(
R-HSA-9664873
)
R-HSA-9664880
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1
See in Reactome
R-HSA-9664881
(
R-HSA-9664873
)
R-HSA-9664881
Reaction Name: NBR1 binds ATM:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664883
(
R-HSA-9664873
)
R-HSA-9664883
Reaction Name: ATM:PEX5 translocates from cytosol to peroxisomal membrane
See in Reactome
R-HSA-9664888
(
R-HSA-9664873
)
R-HSA-9664888
Reaction Name: ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9664892
(
R-HSA-9664873
)
R-HSA-9664892
Reaction Name: SQSTM1 binds ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674127
(
R-HSA-9664873
)
R-HSA-9674127
Reaction Name: USP30 deubiquitinates ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674131
(
R-HSA-9664873
)
R-HSA-9674131
Reaction Name: USP30 binds ATM dimer:Ub-p-PEX5
See in Reactome
|
MONDO:0018266 |
ATM |
Q13315 |
2.7.11.1
|
R-HSA-2559586
R-HSA-2559586
Reactome Name: DNA Damage/Telomere Stress Induced Senescence
See in Reactome
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-9664873
R-HSA-69473
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-69541
R-HSA-6803207
R-HSA-6803207
Reactome Name: TP53 Regulates Transcription of Caspase Activators and Caspases
See in Reactome
R-HSA-6803204
R-HSA-6803204
Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5693548
R-HSA-5693548
Reactome Name: Sensing of DNA Double Strand Breaks
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-912446
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-2559583
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-1640170
R-HSA-8953897
R-HSA-73857
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-5633007
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-5633008
R-HSA-5633008
Reactome Name: TP53 Regulates Transcription of Cell Death Genes
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-5693538
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-1474165
R-HSA-9612973
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-9663891
R-HSA-1632852
R-HSA-69481
R-HSA-69615
R-HSA-1500620
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
|
Cell Cycle
Cellular responses to stimuli
Gene expression (Transcription)
Reproduction
Autophagy
DNA Repair
|
R-HSA-3371567
(
R-HSA-3371453
)
R-HSA-3371567
Reaction Name: DBC1 is phosphorylated by ATM/ART
See in Reactome
R-HSA-349444
(
R-HSA-349425;
R-HSA-69541
)
R-HSA-349444
Reaction Name: Phosphorylation of COP1 at Ser-387 by ATM
See in Reactome
R-HSA-349455
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-5682018
(
R-HSA-2559586
)
R-HSA-5682018
Reaction Name: MRN complex bound to shortened telomeres recruits ATM
See in Reactome
R-HSA-5682026
(
R-HSA-2559586
)
R-HSA-5682026
Reaction Name: MRN bound to shortened telomeres activates ATM
See in Reactome
R-HSA-5682044
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5682044
Reaction Name: KAT5 acetylates ATM at DNA DSBs
See in Reactome
R-HSA-5682586
(
R-HSA-5693565
)
R-HSA-5682586
Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs
See in Reactome
R-HSA-5682588
(
R-HSA-5693565
)
R-HSA-5682588
Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs
See in Reactome
R-HSA-5682598
(
R-HSA-5693565
)
R-HSA-5682607
(
R-HSA-5693565
)
R-HSA-5682607
Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
See in Reactome
R-HSA-5682629
(
R-HSA-5693565
)
R-HSA-5682629
Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
See in Reactome
R-HSA-5682858
(
R-HSA-5693565
)
R-HSA-5682858
Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX
See in Reactome
R-HSA-5682863
(
R-HSA-5693565
)
R-HSA-5682965
(
R-HSA-5693565
)
R-HSA-5682965
Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs
See in Reactome
R-HSA-5682967
(
R-HSA-5693565
)
R-HSA-5682983
(
R-HSA-5693565
)
R-HSA-5682992
(
R-HSA-5693565
)
R-HSA-5683077
(
R-HSA-5693565
)
R-HSA-5683077
Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B
See in Reactome
R-HSA-5683384
(
R-HSA-5693565
)
R-HSA-5683384
Reaction Name: UIMC1 and FAM175A bind DNA DSBs
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683405
(
R-HSA-5693565
)
R-HSA-5683405
Reaction Name: PPP5C dephosphorylates TP53BP1
See in Reactome
R-HSA-5683425
(
R-HSA-5693565
)
R-HSA-5683425
Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
R-HSA-5683986
(
R-HSA-5693565
)
R-HSA-5683986
Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX
See in Reactome
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684081
(
R-HSA-5693607
)
R-HSA-5684081
Reaction Name: MRN complex binds CDK2 and RBBP8
See in Reactome
R-HSA-5684096
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684140
(
R-HSA-5693607
)
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686578
(
R-HSA-5693565
)
R-HSA-5686578
Reaction Name: Activated ATM phosphorylates ABL1
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5686704
(
R-HSA-5693571
)
R-HSA-5686704
Reaction Name: Activated ATM phosphorylates DCLRE1C
See in Reactome
R-HSA-5686900
(
R-HSA-5693571
)
R-HSA-5686900
Reaction Name: TP53BP1 recruits DCLRE1C to ATM
See in Reactome
R-HSA-5693536
(
R-HSA-5693565
)
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693540
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693549
(
R-HSA-5693565
)
R-HSA-5693549
Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693566
(
R-HSA-5693565
)
R-HSA-5693566
Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693583
(
R-HSA-5693565
)
R-HSA-5693583
Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693598
(
R-HSA-5693565
)
R-HSA-5693599
(
R-HSA-5693571
)
R-HSA-5693599
Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break
See in Reactome
R-HSA-5693602
(
R-HSA-5693565
)
R-HSA-5693602
Reaction Name: ATM recognizes H2AFX-Nucleosomes
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693609
(
R-HSA-2559586;
R-HSA-5693565;
R-HSA-6804756;
R-HSA-69541
)
R-HSA-5693609
Reaction Name: ATM phosphorylates TP53 at S15
See in Reactome
R-HSA-5693612
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693612
Reaction Name: MRN complex bound to DNA ends recruits ATM
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6792712
(
R-HSA-2559586
)
R-HSA-6792712
Reaction Name: KAT5 acetylates ATM at shortened telomeres
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6798372
(
R-HSA-6804756
)
R-HSA-6799097
(
R-HSA-6803204
)
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-6800490
(
R-HSA-6803207
)
R-HSA-6804276
(
R-HSA-6804760
)
R-HSA-6804741
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-6804741
Reaction Name: MDM2 forms homo- or heterodimers
See in Reactome
R-HSA-6804955
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-912429
(
R-HSA-912446
)
R-HSA-912429
Reaction Name: Resolution of meiotic holliday junction
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912496
(
R-HSA-912446
)
R-HSA-912496
Reaction Name: Formation of meiotic holliday junction
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9664850
(
R-HSA-9664873
)
R-HSA-9664855
(
R-HSA-9664873
)
R-HSA-9664855
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664862
(
R-HSA-9664873
)
R-HSA-9664862
Reaction Name: ATM dimer:PEX5 phosphorylates PEX5
See in Reactome
R-HSA-9664879
(
R-HSA-9664873
)
R-HSA-9664880
(
R-HSA-9664873
)
R-HSA-9664880
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1
See in Reactome
R-HSA-9664881
(
R-HSA-9664873
)
R-HSA-9664881
Reaction Name: NBR1 binds ATM:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664883
(
R-HSA-9664873
)
R-HSA-9664883
Reaction Name: ATM:PEX5 translocates from cytosol to peroxisomal membrane
See in Reactome
R-HSA-9664888
(
R-HSA-9664873
)
R-HSA-9664888
Reaction Name: ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9664892
(
R-HSA-9664873
)
R-HSA-9664892
Reaction Name: SQSTM1 binds ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674127
(
R-HSA-9664873
)
R-HSA-9674127
Reaction Name: USP30 deubiquitinates ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674131
(
R-HSA-9664873
)
R-HSA-9674131
Reaction Name: USP30 binds ATM dimer:Ub-p-PEX5
See in Reactome
|
MONDO:0018876 |
MONDO:0018876
Disease Name: mantle cell lymphoma
Orphanet id: Orphanet:52416
All associated enzymes in DAR:
ATM
. The disease is also associated to other non-enzyme proteins (not in DAR).
ATM |
Q13315 |
2.7.11.1
|
R-HSA-2559586
R-HSA-2559586
Reactome Name: DNA Damage/Telomere Stress Induced Senescence
See in Reactome
R-HSA-6804760
R-HSA-6804760
Reactome Name: Regulation of TP53 Activity through Methylation
See in Reactome
R-HSA-6796648
R-HSA-6796648
Reactome Name: TP53 Regulates Transcription of DNA Repair Genes
See in Reactome
R-HSA-5693554
R-HSA-5693554
Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
See in Reactome
R-HSA-5693579
R-HSA-5693579
Reactome Name: Homologous DNA Pairing and Strand Exchange
See in Reactome
R-HSA-5693571
R-HSA-5693571
Reactome Name: Nonhomologous End-Joining (NHEJ)
See in Reactome
R-HSA-9664873
R-HSA-69473
R-HSA-5693607
R-HSA-5693607
Reactome Name: Processing of DNA double-strand break ends
See in Reactome
R-HSA-5685942
R-HSA-5685942
Reactome Name: HDR through Homologous Recombination (HRR)
See in Reactome
R-HSA-69541
R-HSA-6803207
R-HSA-6803207
Reactome Name: TP53 Regulates Transcription of Caspase Activators and Caspases
See in Reactome
R-HSA-6803204
R-HSA-6803204
Reactome Name: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
See in Reactome
R-HSA-5693568
R-HSA-5693568
Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates
See in Reactome
R-HSA-5693548
R-HSA-5693548
Reactome Name: Sensing of DNA Double Strand Breaks
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-6804756
R-HSA-6804756
Reactome Name: Regulation of TP53 Activity through Phosphorylation
See in Reactome
R-HSA-5693565
R-HSA-5693565
Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-912446
R-HSA-5693616
R-HSA-5693616
Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange
See in Reactome
R-HSA-5685938
R-HSA-5685938
Reactome Name: HDR through Single Strand Annealing (SSA)
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-2559583
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-1640170
R-HSA-8953897
R-HSA-73857
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-5633007
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-5633008
R-HSA-5633008
Reactome Name: TP53 Regulates Transcription of Cell Death Genes
See in Reactome
R-HSA-5693606
R-HSA-5693606
Reactome Name: DNA Double Strand Break Response
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-5693538
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-1474165
R-HSA-9612973
R-HSA-5693567
R-HSA-5693567
Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
See in Reactome
R-HSA-9663891
R-HSA-1632852
R-HSA-69481
R-HSA-69615
R-HSA-1500620
R-HSA-73894
R-HSA-5693532
R-HSA-5693532
Reactome Name: DNA Double-Strand Break Repair
See in Reactome
R-HSA-5693537
R-HSA-5693537
Reactome Name: Resolution of D-Loop Structures
See in Reactome
|
Cell Cycle
Cellular responses to stimuli
Gene expression (Transcription)
Reproduction
Autophagy
DNA Repair
|
R-HSA-3371567
(
R-HSA-3371453
)
R-HSA-3371567
Reaction Name: DBC1 is phosphorylated by ATM/ART
See in Reactome
R-HSA-349444
(
R-HSA-349425;
R-HSA-69541
)
R-HSA-349444
Reaction Name: Phosphorylation of COP1 at Ser-387 by ATM
See in Reactome
R-HSA-349455
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-5682018
(
R-HSA-2559586
)
R-HSA-5682018
Reaction Name: MRN complex bound to shortened telomeres recruits ATM
See in Reactome
R-HSA-5682026
(
R-HSA-2559586
)
R-HSA-5682026
Reaction Name: MRN bound to shortened telomeres activates ATM
See in Reactome
R-HSA-5682044
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5682044
Reaction Name: KAT5 acetylates ATM at DNA DSBs
See in Reactome
R-HSA-5682586
(
R-HSA-5693565
)
R-HSA-5682586
Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs
See in Reactome
R-HSA-5682588
(
R-HSA-5693565
)
R-HSA-5682588
Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs
See in Reactome
R-HSA-5682598
(
R-HSA-5693565
)
R-HSA-5682607
(
R-HSA-5693565
)
R-HSA-5682607
Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
See in Reactome
R-HSA-5682629
(
R-HSA-5693565
)
R-HSA-5682629
Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
See in Reactome
R-HSA-5682858
(
R-HSA-5693565
)
R-HSA-5682858
Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX
See in Reactome
R-HSA-5682863
(
R-HSA-5693565
)
R-HSA-5682965
(
R-HSA-5693565
)
R-HSA-5682965
Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs
See in Reactome
R-HSA-5682967
(
R-HSA-5693565
)
R-HSA-5682983
(
R-HSA-5693565
)
R-HSA-5682992
(
R-HSA-5693565
)
R-HSA-5683077
(
R-HSA-5693565
)
R-HSA-5683077
Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B
See in Reactome
R-HSA-5683384
(
R-HSA-5693565
)
R-HSA-5683384
Reaction Name: UIMC1 and FAM175A bind DNA DSBs
See in Reactome
R-HSA-5683385
(
R-HSA-5693565
)
R-HSA-5683385
Reaction Name: Formation of BRCA1-A complex at DNA DSBs
See in Reactome
R-HSA-5683405
(
R-HSA-5693565
)
R-HSA-5683405
Reaction Name: PPP5C dephosphorylates TP53BP1
See in Reactome
R-HSA-5683425
(
R-HSA-5693565
)
R-HSA-5683425
Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5683735
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-5683735
Reaction Name: CHEK2 is recruited to DNA DSBs
See in Reactome
R-HSA-5683801
(
R-HSA-5693565
)
R-HSA-5683964
(
R-HSA-5693565
)
R-HSA-5683967
(
R-HSA-5693565
)
R-HSA-5683967
Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
See in Reactome
R-HSA-5683986
(
R-HSA-5693565
)
R-HSA-5683986
Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX
See in Reactome
R-HSA-5684052
(
R-HSA-5693607
)
R-HSA-5684071
(
R-HSA-5693607
)
R-HSA-5684081
(
R-HSA-5693607
)
R-HSA-5684081
Reaction Name: MRN complex binds CDK2 and RBBP8
See in Reactome
R-HSA-5684096
(
R-HSA-5693607
)
R-HSA-5684108
(
R-HSA-5693607
)
R-HSA-5684108
Reaction Name: BRCA1 binds phosphorylated RBBP8
See in Reactome
R-HSA-5684140
(
R-HSA-5693607
)
R-HSA-5684875
(
R-HSA-5693607
)
R-HSA-5684875
Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs
See in Reactome
R-HSA-5684882
(
R-HSA-5693607
)
R-HSA-5684882
Reaction Name: CHEK1 is recruited to resected DNA DSBs
See in Reactome
R-HSA-5684887
(
R-HSA-5693607
)
R-HSA-5684887
Reaction Name: Activation of CHEK1 at resected DNA DSBs
See in Reactome
R-HSA-5685011
(
R-HSA-5693607
)
R-HSA-5685156
(
R-HSA-5693607
)
R-HSA-5685341
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5685341
Reaction Name: BCDX2 complex stabilizes RAD51 filament
See in Reactome
R-HSA-5685838
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5685838
Reaction Name: CX3 complex binds D-loop structures
See in Reactome
R-HSA-5685985
(
R-HSA-5693607
)
R-HSA-5685985
Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment
See in Reactome
R-HSA-5685994
(
R-HSA-5693607
)
R-HSA-5685994
Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2
See in Reactome
R-HSA-5686410
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686410
Reaction Name: BLM mediates dissolution of double Holliday junction
See in Reactome
R-HSA-5686440
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686440
Reaction Name: MUS81:EME1,EME2 cleaves D-loop
See in Reactome
R-HSA-5686469
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686469
Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
See in Reactome
R-HSA-5686483
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5686483
Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5686578
(
R-HSA-5693565
)
R-HSA-5686578
Reaction Name: Activated ATM phosphorylates ABL1
See in Reactome
R-HSA-5686642
(
R-HSA-5685938
)
R-HSA-5686642
Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs
See in Reactome
R-HSA-5686657
(
R-HSA-5685938
)
R-HSA-5686657
Reaction Name: ERCC1:XPF cleaves flaps generated by SSA
See in Reactome
R-HSA-5686685
(
R-HSA-5693571
)
R-HSA-5686685
Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
See in Reactome
R-HSA-5686704
(
R-HSA-5693571
)
R-HSA-5686704
Reaction Name: Activated ATM phosphorylates DCLRE1C
See in Reactome
R-HSA-5686900
(
R-HSA-5693571
)
R-HSA-5686900
Reaction Name: TP53BP1 recruits DCLRE1C to ATM
See in Reactome
R-HSA-5693536
(
R-HSA-5693565
)
R-HSA-5693539
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693539
Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis
See in Reactome
R-HSA-5693540
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693542
(
R-HSA-5693607
)
R-HSA-5693542
Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs
See in Reactome
R-HSA-5693549
(
R-HSA-5693565
)
R-HSA-5693549
Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs
See in Reactome
R-HSA-5693551
(
R-HSA-5693565
)
R-HSA-5693551
Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM
See in Reactome
R-HSA-5693561
(
R-HSA-5685942;
R-HSA-5693579;
R-HSA-5693616
)
R-HSA-5693561
Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs
See in Reactome
R-HSA-5693564
(
R-HSA-5685938
)
R-HSA-5693564
Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends
See in Reactome
R-HSA-5693566
(
R-HSA-5693565
)
R-HSA-5693566
Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs
See in Reactome
R-HSA-5693580
(
R-HSA-5685938
)
R-HSA-5693580
Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs
See in Reactome
R-HSA-5693583
(
R-HSA-5693565
)
R-HSA-5693583
Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci
See in Reactome
R-HSA-5693584
(
R-HSA-5685942;
R-HSA-5693568
)
R-HSA-5693584
Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
See in Reactome
R-HSA-5693589
(
R-HSA-5685942;
R-HSA-5693554
)
R-HSA-5693589
Reaction Name: D-loop dissociation and strand annealing
See in Reactome
R-HSA-5693593
(
R-HSA-5685942
)
R-HSA-5693593
Reaction Name: D-loop extension by DNA polymerases
See in Reactome
R-HSA-5693598
(
R-HSA-5693565
)
R-HSA-5693599
(
R-HSA-5693571
)
R-HSA-5693599
Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break
See in Reactome
R-HSA-5693602
(
R-HSA-5693565
)
R-HSA-5693602
Reaction Name: ATM recognizes H2AFX-Nucleosomes
See in Reactome
R-HSA-5693608
(
R-HSA-5693607
)
R-HSA-5693608
Reaction Name: Initial resection of double-strand break ends
See in Reactome
R-HSA-5693609
(
R-HSA-2559586;
R-HSA-5693565;
R-HSA-6804756;
R-HSA-69541
)
R-HSA-5693609
Reaction Name: ATM phosphorylates TP53 at S15
See in Reactome
R-HSA-5693612
(
R-HSA-2559586;
R-HSA-5693548
)
R-HSA-5693612
Reaction Name: MRN complex bound to DNA ends recruits ATM
See in Reactome
R-HSA-5693620
(
R-HSA-5685942;
R-HSA-5693579
)
R-HSA-5693620
Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51
See in Reactome
R-HSA-6792712
(
R-HSA-2559586
)
R-HSA-6792712
Reaction Name: KAT5 acetylates ATM at shortened telomeres
See in Reactome
R-HSA-6797712
(
R-HSA-6796648
)
R-HSA-6797712
Reaction Name: CDK12 stimulates expression of DNA repair genes
See in Reactome
R-HSA-6798372
(
R-HSA-6804756
)
R-HSA-6799097
(
R-HSA-6803204
)
R-HSA-6799332
(
R-HSA-6804756;
R-HSA-69473
)
R-HSA-6800490
(
R-HSA-6803207
)
R-HSA-6804276
(
R-HSA-6804760
)
R-HSA-6804741
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-6804741
Reaction Name: MDM2 forms homo- or heterodimers
See in Reactome
R-HSA-6804955
(
R-HSA-6804757;
R-HSA-69541
)
R-HSA-69891
(
R-HSA-5693565;
R-HSA-69473
)
R-HSA-69891
Reaction Name: Phosphorylation and activation of CHEK2 by ATM
See in Reactome
R-HSA-912429
(
R-HSA-912446
)
R-HSA-912429
Reaction Name: Resolution of meiotic holliday junction
See in Reactome
R-HSA-912458
(
R-HSA-912446
)
R-HSA-912458
Reaction Name: Formation of meiotic heteroduplex
See in Reactome
R-HSA-912496
(
R-HSA-912446
)
R-HSA-912496
Reaction Name: Formation of meiotic holliday junction
See in Reactome
R-HSA-912503
(
R-HSA-912446
)
R-HSA-912503
Reaction Name: Formation of meiotic single-stranded DNA invasion complex
See in Reactome
R-HSA-9664850
(
R-HSA-9664873
)
R-HSA-9664855
(
R-HSA-9664873
)
R-HSA-9664855
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664862
(
R-HSA-9664873
)
R-HSA-9664862
Reaction Name: ATM dimer:PEX5 phosphorylates PEX5
See in Reactome
R-HSA-9664879
(
R-HSA-9664873
)
R-HSA-9664880
(
R-HSA-9664873
)
R-HSA-9664880
Reaction Name: MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1
See in Reactome
R-HSA-9664881
(
R-HSA-9664873
)
R-HSA-9664881
Reaction Name: NBR1 binds ATM:Ub-p-PEX5:SQSTM1
See in Reactome
R-HSA-9664883
(
R-HSA-9664873
)
R-HSA-9664883
Reaction Name: ATM:PEX5 translocates from cytosol to peroxisomal membrane
See in Reactome
R-HSA-9664888
(
R-HSA-9664873
)
R-HSA-9664888
Reaction Name: ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9664892
(
R-HSA-9664873
)
R-HSA-9664892
Reaction Name: SQSTM1 binds ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674127
(
R-HSA-9664873
)
R-HSA-9674127
Reaction Name: USP30 deubiquitinates ATM dimer:Ub-p-PEX5
See in Reactome
R-HSA-9674131
(
R-HSA-9664873
)
R-HSA-9674131
Reaction Name: USP30 binds ATM dimer:Ub-p-PEX5
See in Reactome
|
MONDO:0033669 |
MAPK1 |
P28482 |
2.7.11.24
|
R-HSA-2559585
R-HSA-445144
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-111995
R-HSA-2559580
R-HSA-2559580
Reactome Name: Oxidative Stress Induced Senescence
See in Reactome
R-HSA-198753
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-8940973
R-HSA-8940973
Reactome Name: RUNX2 regulates osteoblast differentiation
See in Reactome
R-HSA-170968
R-HSA-437239
R-HSA-444257
R-HSA-6798695
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-1181150
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-982772
R-HSA-982772
Reactome Name: Growth hormone receptor signaling
See in Reactome
R-HSA-9634635
R-HSA-9634635
Reactome Name: Estrogen-stimulated signaling through PRKCZ
See in Reactome
R-HSA-2559582
R-HSA-2559582
Reactome Name: Senescence-Associated Secretory Phenotype (SASP)
See in Reactome
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-881907
R-HSA-881907
Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK
See in Reactome
R-HSA-5673001
R-HSA-8943724
R-HSA-8943724
Reactome Name: Regulation of PTEN gene transcription
See in Reactome
R-HSA-2173796
R-HSA-2173796
Reactome Name: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
See in Reactome
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
R-HSA-1502540
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5675221
R-HSA-5675221
Reactome Name: Negative regulation of MAPK pathway
See in Reactome
R-HSA-450341
R-HSA-450341
Reactome Name: Activation of the AP-1 family of transcription factors
See in Reactome
R-HSA-5674499
R-HSA-5674499
Reactome Name: Negative feedback regulation of MAPK pathway
See in Reactome
R-HSA-74749
R-HSA-375165
R-HSA-375165
Reactome Name: NCAM signaling for neurite out-growth
See in Reactome
R-HSA-8939211
R-HSA-5674135
R-HSA-202670
R-HSA-879415
R-HSA-879415
Reactome Name: Advanced glycosylation endproduct receptor signaling
See in Reactome
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-162658
R-HSA-162658
Reactome Name: Golgi Cisternae Pericentriolar Stack Reorganization
See in Reactome
R-HSA-456926
R-HSA-456926
Reactome Name: Thrombin signalling through proteinase activated receptors (PARs)
See in Reactome
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-112411
R-HSA-9627069
R-HSA-9627069
Reactome Name: Regulation of the apoptosome activity
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-3371453
R-HSA-3371453
Reactome Name: Regulation of HSF1-mediated heat shock response
See in Reactome
|
R-HSA-111996
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-1640170
R-HSA-1266738
R-HSA-73857
R-HSA-212436
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-2262752
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-112316
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-373760
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-450294
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-416476
R-HSA-3371556
R-HSA-3371556
Reactome Name: Cellular response to heat stress
See in Reactome
R-HSA-111471
R-HSA-111471
Reactome Name: Apoptotic factor-mediated response
See in Reactome
R-HSA-168256
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-442742
R-HSA-442742
Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
See in Reactome
R-HSA-450282
R-HSA-450282
Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases
See in Reactome
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-111461
R-HSA-111461
Reactome Name: Cytochrome c-mediated apoptotic response
See in Reactome
R-HSA-69278
R-HSA-198725
R-HSA-198725
Reactome Name: Nuclear Events (kinase and transcription factor activation)
See in Reactome
R-HSA-166166
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-168249
R-HSA-68886
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-187037
R-HSA-169893
R-HSA-169893
Reactome Name: Prolonged ERK activation events
See in Reactome
R-HSA-112043
R-HSA-112040
R-HSA-5654738
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-422475
R-HSA-68875
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-2559583
R-HSA-8941326
R-HSA-8941326
Reactome Name: RUNX2 regulates bone development
See in Reactome
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-5357801
R-HSA-74752
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-74160
R-HSA-168898
R-HSA-2173793
R-HSA-2173793
Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-8953897
R-HSA-170834
R-HSA-170834
Reactome Name: Signaling by TGF-beta Receptor Complex
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006936
R-HSA-9006936
Reactome Name: Signaling by TGFB family members
See in Reactome
R-HSA-111885
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-187687
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
R-HSA-449147
R-HSA-418594
R-HSA-194315
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-5684996
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-5654743
R-HSA-5654741
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-190236
R-HSA-388396
R-HSA-5654736
R-HSA-195258
R-HSA-1257604
R-HSA-372790
R-HSA-6807070
R-HSA-448424
R-HSA-109581
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-111458
R-HSA-109582
R-HSA-162582
|
Cell Cycle
Developmental Biology
Neuronal System
Immune System
Programmed Cell Death
Gene expression (Transcription)
Cellular responses to stimuli
Hemostasis
Signal Transduction
|
R-HSA-109822
(
R-HSA-74749
)
R-HSA-109822
Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1
See in Reactome
R-HSA-109823
(
R-HSA-74749
)
R-HSA-109823
Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2
See in Reactome
R-HSA-109858
(
R-HSA-112409;
R-HSA-112411
)
R-HSA-109862
(
R-HSA-112409;
R-HSA-112411;
R-HSA-445144
)
R-HSA-109864
(
R-HSA-112409;
R-HSA-112411
)
R-HSA-109864
Reaction Name: Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2
See in Reactome
R-HSA-111898
(
R-HSA-111995
)
R-HSA-111898
Reaction Name: Phosphorylation of cPLA2 by ERK-2
See in Reactome
R-HSA-1168459
(
R-HSA-982772
)
R-HSA-1295634
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1295634
Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation
See in Reactome
R-HSA-168053
(
R-HSA-450341
)
R-HSA-168053
Reaction Name: Phosphorylated MAPKs phosphorylate ATF-2
See in Reactome
R-HSA-173488
(
R-HSA-1181150;
R-HSA-1502540;
R-HSA-2173796
)
R-HSA-173488
Reaction Name: The SMAD2/3:SMAD4 complex transfers to the nucleus
See in Reactome
R-HSA-198731
(
R-HSA-198753;
R-HSA-8939211;
R-HSA-9634638
)
R-HSA-198746
(
R-HSA-198753;
R-HSA-2559582;
R-HSA-881907
)
R-HSA-198756
(
R-HSA-198753;
R-HSA-375165
)
R-HSA-199959
(
R-HSA-198753;
R-HSA-202670
)
R-HSA-199959
Reaction Name: ERKs are inactivated by protein phosphatase 2A
See in Reactome
R-HSA-2029469
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029469
Reaction Name: p-ERK phosphorylates WAVEs and ABI
See in Reactome
R-HSA-203797
(
R-HSA-198753;
R-HSA-202670
)
R-HSA-203797
Reaction Name: ERKs are inactivated by dual-specific phosphatases (DUSPs)
See in Reactome
R-HSA-2422927
(
R-HSA-162658
)
R-HSA-2422927
Reaction Name: MAPK3-3 or MAPK1 phosphorylate GORASP2
See in Reactome
R-HSA-3132737
(
R-HSA-2559585
)
R-HSA-3132737
Reaction Name: MAPKs phosphorylate ETS1 and ETS2
See in Reactome
R-HSA-3209160
(
R-HSA-2559585
)
R-HSA-3209160
Reaction Name: Activated ERKs phosphorylate ERF
See in Reactome
R-HSA-3209177
(
R-HSA-2559585
)
R-HSA-3223236
(
R-HSA-2559580
)
R-HSA-3223236
Reaction Name: RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS)
See in Reactome
R-HSA-3371531
(
R-HSA-3371453
)
R-HSA-3371531
Reaction Name: Constitutive phosphorylation by pERK1/2
See in Reactome
R-HSA-3857329
(
R-HSA-2559582
)
R-HSA-3857329
Reaction Name: MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB
See in Reactome
R-HSA-418158
(
R-HSA-456926
)
R-HSA-418158
Reaction Name: SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1)
See in Reactome
R-HSA-418163
(
R-HSA-456926
)
R-HSA-418163
Reaction Name: Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)
See in Reactome
R-HSA-418170
(
R-HSA-456926
)
R-HSA-418176
(
R-HSA-456926
)
R-HSA-418200
(
R-HSA-456926
)
R-HSA-418200
Reaction Name: SRC-1 bound to ARRB2 is not activated
See in Reactome
R-HSA-445079
(
R-HSA-437239
)
R-HSA-450325
(
R-HSA-2559580;
R-HSA-2871796;
R-HSA-450341
)
R-HSA-450325
Reaction Name: c-FOS activation by phospho ERK1/2
See in Reactome
R-HSA-5654560
(
R-HSA-5654726
)
R-HSA-5654560
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2.
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654565
(
R-HSA-5654732
)
R-HSA-5654565
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2.
See in Reactome
R-HSA-5654566
(
R-HSA-5654733
)
R-HSA-5654566
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2.
See in Reactome
R-HSA-5672972
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672972
Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex
See in Reactome
R-HSA-5672973
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672978
Reaction Name: RAF phosphorylates MAP2K dimer
See in Reactome
R-HSA-5672980
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5672980
Reaction Name: Dissociation of RAS:RAF complex
See in Reactome
R-HSA-5674130
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674130
Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane
See in Reactome
R-HSA-5674132
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674132
Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components
See in Reactome
R-HSA-5674366
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674366
Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs
See in Reactome
R-HSA-5674373
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-5674373
Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane
See in Reactome
R-HSA-5674385
(
R-HSA-112409;
R-HSA-170968;
R-HSA-5673001
)
R-HSA-5674387
(
R-HSA-112409;
R-HSA-5673001
)
R-HSA-5674387
Reaction Name: Phosphorylated MAPKs translocate into the nucleus
See in Reactome
R-HSA-5674496
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5674496
Reaction Name: Activated MAPKs phosphorylate MAP2K1
See in Reactome
R-HSA-5675194
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675194
Reaction Name: Activated MAPK phosphorylates RAF1
See in Reactome
R-HSA-5675198
(
R-HSA-5673001;
R-HSA-5674499;
R-HSA-5675221
)
R-HSA-5675198
Reaction Name: Activated MAPKs phosphorylate BRAF
See in Reactome
R-HSA-5675206
(
R-HSA-112409;
R-HSA-5673001
)
R-HSA-5675206
Reaction Name: PEA15 binds MAPK monomers and dimers
See in Reactome
R-HSA-5675373
(
R-HSA-112409;
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675373
Reaction Name: Nuclear DUSPs dephosphorylate MAPKs
See in Reactome
R-HSA-5675376
(
R-HSA-112409;
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-5675376
Reaction Name: Cytosolic DUSPs dephosphorylate MAPKs
See in Reactome
R-HSA-6798751
(
R-HSA-6798695
)
R-HSA-6798751
Reaction Name: Exocytosis of azurophil granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-6811454
(
R-HSA-6811558
)
R-HSA-6811472
(
R-HSA-6811558
)
R-HSA-6811472
Reaction Name: IER3 recruits MAPKs to PP2A-B56-beta,gamma
See in Reactome
R-HSA-879362
(
R-HSA-879415
)
R-HSA-8944047
(
R-HSA-8943724
)
R-HSA-8944047
Reaction Name: JUN binds the PTEN gene promoter
See in Reactome
R-HSA-9009208
(
R-HSA-8940973
)
R-HSA-9009208
Reaction Name: Activated ERKs phosphorylate RUNX2
See in Reactome
R-HSA-9032751
(
R-HSA-8939211
)
R-HSA-9032751
Reaction Name: Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3
See in Reactome
R-HSA-9610152
(
R-HSA-170968
)
R-HSA-9610152
Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome
See in Reactome
R-HSA-9610153
(
R-HSA-170968
)
R-HSA-9610153
Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
See in Reactome
R-HSA-9610154
(
R-HSA-170968
)
R-HSA-9610154
Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs
See in Reactome
R-HSA-9610156
(
R-HSA-170968
)
R-HSA-9610156
Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
See in Reactome
R-HSA-9610166
(
R-HSA-170968
)
R-HSA-9610166
Reaction Name: p-T,Y MAPK dimers translocate to nucleus
See in Reactome
R-HSA-9619843
(
R-HSA-444257
)
R-HSA-9626832
(
R-HSA-5668599
)
R-HSA-9626832
Reaction Name: MAPK1 or MAPK3 phosphorylates NCF1 at Ser345
See in Reactome
R-HSA-9627089
(
R-HSA-9627069
)
R-HSA-9627089
Reaction Name: CASP9 is phosphorylated at T125
See in Reactome
R-HSA-9632873
(
R-HSA-8939211;
R-HSA-9634638
)
R-HSA-9632873
Reaction Name: p-S10 CDKN1B translocates to the cytosol
See in Reactome
R-HSA-9632910
(
R-HSA-8939211;
R-HSA-9634635
)
R-HSA-9632910
Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus
See in Reactome
R-HSA-9635739
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-9635739
Reaction Name: PTPN7 dephosphorylates p-T,Y-MAPKs
See in Reactome
R-HSA-9635743
(
R-HSA-5673001;
R-HSA-5675221
)
R-HSA-9657599
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657599
Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks
See in Reactome
R-HSA-9657603
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657603
Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs
See in Reactome
R-HSA-9657606
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657606
Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
See in Reactome
R-HSA-9657608
(
R-HSA-5673001;
R-HSA-5674135
)
R-HSA-9657608
Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK
See in Reactome
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