MONDO:0007103 |
SOD1 |
P00441 |
1.15.1.1
|
R-HSA-3299685
R-HSA-3299685
Reactome Name: Detoxification of Reactive Oxygen Species
See in Reactome
R-HSA-8950505
R-HSA-8950505
Reactome Name: Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
See in Reactome
R-HSA-114608
|
R-HSA-8953897
R-HSA-449147
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-168256
R-HSA-2262752
R-HSA-76005
R-HSA-76005
Reactome Name: Response to elevated platelet cytosolic Ca2+
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9711123
R-HSA-9711123
Reactome Name: Cellular response to chemical stress
See in Reactome
R-HSA-9020591
R-HSA-109582
|
Cellular responses to stimuli
Immune System
Hemostasis
|
R-HSA-3299691
(
R-HSA-3299685
)
R-HSA-3299691
Reaction Name: SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)
See in Reactome
R-HSA-3299753
(
R-HSA-3299685
)
R-HSA-3299753
Reaction Name: CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1
See in Reactome
R-HSA-3697860
(
R-HSA-3299685
)
R-HSA-3697860
Reaction Name: SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+
See in Reactome
R-HSA-3777112
(
R-HSA-3299685
)
R-HSA-3777112
Reaction Name: SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)
See in Reactome
R-HSA-3780958
(
R-HSA-3299685
)
R-HSA-3780958
Reaction Name: SOD1:Zn2+ apoenzyme binds CCS:Cu1+ (mitochondrial)
See in Reactome
R-HSA-3780979
(
R-HSA-3299685
)
R-HSA-3780979
Reaction Name: CCS transfers Cu to SOD1 (mitochondrial)
See in Reactome
R-HSA-482772
(
R-HSA-114608
)
R-HSA-482772
Reaction Name: Release of platelet cytosolic components
See in Reactome
R-HSA-8950771
(
R-HSA-8950505
)
R-HSA-8951723
(
R-HSA-3299685
)
R-HSA-8951723
Reaction Name: 2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates
See in Reactome
|
MONDO:0007204 |
P4HB |
P07237 |
5.3.4.1
|
R-HSA-381426
R-HSA-381426
Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
See in Reactome
R-HSA-9020591
R-HSA-8963888
R-HSA-8964041
R-HSA-5358346
R-HSA-9020933
R-HSA-1650814
R-HSA-1650814
Reactome Name: Collagen biosynthesis and modifying enzymes
See in Reactome
R-HSA-3299685
R-HSA-3299685
Reactome Name: Detoxification of Reactive Oxygen Species
See in Reactome
R-HSA-8866423
R-HSA-8957275
R-HSA-8957275
Reactome Name: Post-translational protein phosphorylation
See in Reactome
|
R-HSA-8963899
R-HSA-174824
R-HSA-174824
Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance
See in Reactome
R-HSA-449147
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-8953897
R-HSA-168256
R-HSA-2262752
R-HSA-382551
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-1474290
R-HSA-1474244
R-HSA-1474244
Reactome Name: Extracellular matrix organization
See in Reactome
R-HSA-8963898
R-HSA-392499
R-HSA-5358351
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
R-HSA-9711123
R-HSA-9711123
Reactome Name: Cellular response to chemical stress
See in Reactome
|
Cellular responses to stimuli
Immune System
Transport of small molecules
Extracellular matrix organization
Metabolism of proteins
Signal Transduction
|
R-HSA-1650808
(
R-HSA-1650814
)
R-HSA-1650808
Reaction Name: Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines
See in Reactome
R-HSA-174741
(
R-HSA-8963888
)
R-HSA-174741
Reaction Name: ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron
See in Reactome
R-HSA-174786
(
R-HSA-8963888
)
R-HSA-174786
Reaction Name: ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex
See in Reactome
R-HSA-2002460
(
R-HSA-1650814
)
R-HSA-3341296
(
R-HSA-3299685
)
R-HSA-3341296
Reaction Name: GPX7,8 catalyze peroxidation of P4HB (PDI)
See in Reactome
R-HSA-5358336
(
R-HSA-5358346
)
R-HSA-5358336
Reaction Name: P4HB forms mixed disulphides with Hh precursors
See in Reactome
R-HSA-5358340
(
R-HSA-5358346
)
R-HSA-5358340
Reaction Name: Autoproteolytic cleavage of Hh precursors
See in Reactome
R-HSA-8866329
(
R-HSA-8866423
)
R-HSA-8866329
Reaction Name: MTTP lipidates APOB-100, forming a pre-VLDL
See in Reactome
R-HSA-8948234
(
R-HSA-1650814
)
R-HSA-8948234
Reaction Name: P4HB:4-Hyp collagen propeptides dissociates
See in Reactome
R-HSA-8950113
(
R-HSA-9020591
)
R-HSA-8950183
(
R-HSA-9020933
)
R-HSA-8950456
(
R-HSA-9020591
)
R-HSA-8952289
(
R-HSA-381426;
R-HSA-8957275
)
R-HSA-8952289
Reaction Name: FAM20C phosphorylates FAM20C substrates
See in Reactome
R-HSA-9737780
(
R-HSA-8964041
)
|
MONDO:0008146 |
P4HB |
P07237 |
5.3.4.1
|
R-HSA-381426
R-HSA-381426
Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
See in Reactome
R-HSA-9020591
R-HSA-8963888
R-HSA-8964041
R-HSA-5358346
R-HSA-9020933
R-HSA-1650814
R-HSA-1650814
Reactome Name: Collagen biosynthesis and modifying enzymes
See in Reactome
R-HSA-3299685
R-HSA-3299685
Reactome Name: Detoxification of Reactive Oxygen Species
See in Reactome
R-HSA-8866423
R-HSA-8957275
R-HSA-8957275
Reactome Name: Post-translational protein phosphorylation
See in Reactome
|
R-HSA-8963899
R-HSA-174824
R-HSA-174824
Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance
See in Reactome
R-HSA-449147
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-8953897
R-HSA-168256
R-HSA-2262752
R-HSA-382551
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-1474290
R-HSA-1474244
R-HSA-1474244
Reactome Name: Extracellular matrix organization
See in Reactome
R-HSA-8963898
R-HSA-392499
R-HSA-5358351
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-162582
R-HSA-9711123
R-HSA-9711123
Reactome Name: Cellular response to chemical stress
See in Reactome
|
Cellular responses to stimuli
Immune System
Transport of small molecules
Extracellular matrix organization
Metabolism of proteins
Signal Transduction
|
R-HSA-1650808
(
R-HSA-1650814
)
R-HSA-1650808
Reaction Name: Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines
See in Reactome
R-HSA-174741
(
R-HSA-8963888
)
R-HSA-174741
Reaction Name: ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron
See in Reactome
R-HSA-174786
(
R-HSA-8963888
)
R-HSA-174786
Reaction Name: ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex
See in Reactome
R-HSA-2002460
(
R-HSA-1650814
)
R-HSA-3341296
(
R-HSA-3299685
)
R-HSA-3341296
Reaction Name: GPX7,8 catalyze peroxidation of P4HB (PDI)
See in Reactome
R-HSA-5358336
(
R-HSA-5358346
)
R-HSA-5358336
Reaction Name: P4HB forms mixed disulphides with Hh precursors
See in Reactome
R-HSA-5358340
(
R-HSA-5358346
)
R-HSA-5358340
Reaction Name: Autoproteolytic cleavage of Hh precursors
See in Reactome
R-HSA-8866329
(
R-HSA-8866423
)
R-HSA-8866329
Reaction Name: MTTP lipidates APOB-100, forming a pre-VLDL
See in Reactome
R-HSA-8948234
(
R-HSA-1650814
)
R-HSA-8948234
Reaction Name: P4HB:4-Hyp collagen propeptides dissociates
See in Reactome
R-HSA-8950113
(
R-HSA-9020591
)
R-HSA-8950183
(
R-HSA-9020933
)
R-HSA-8950456
(
R-HSA-9020591
)
R-HSA-8952289
(
R-HSA-381426;
R-HSA-8957275
)
R-HSA-8952289
Reaction Name: FAM20C phosphorylates FAM20C substrates
See in Reactome
R-HSA-9737780
(
R-HSA-8964041
)
|
MONDO:0010184 |
PRDX1 |
Q06830 |
1.11.1.24
|
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-3299685
R-HSA-3299685
Reactome Name: Detoxification of Reactive Oxygen Species
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-8953897
R-HSA-212436
R-HSA-74160
R-HSA-2262752
R-HSA-9711123
R-HSA-9711123
Reactome Name: Cellular response to chemical stress
See in Reactome
R-HSA-73857
|
Cellular responses to stimuli
Gene expression (Transcription)
|
R-HSA-3341343
(
R-HSA-3299685;
R-HSA-5628897
)
R-HSA-3341343
Reaction Name: PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O
See in Reactome
R-HSA-5631885
(
R-HSA-5628897
)
R-HSA-5631903
(
R-HSA-5628897
)
R-HSA-5631903
Reaction Name: SESN1,2,3 bind overoxidized PRDX1
See in Reactome
R-HSA-9759189
()
R-HSA-9759189
Reaction Name: NFE2L2-dependent PRDX1 gene expression
See in Reactome
R-HSA-9760094
()
R-HSA-9760094
Reaction Name: SRXN1 reduces hyperoxidized PRDX1 dimer
See in Reactome
|
MONDO:0010338 |
ATP7A |
Q04656 |
7.2.2.8
|
R-HSA-936837
R-HSA-936837
Reactome Name: Ion transport by P-type ATPases
See in Reactome
R-HSA-3299685
R-HSA-3299685
Reactome Name: Detoxification of Reactive Oxygen Species
See in Reactome
R-HSA-6803544
R-HSA-6803544
Reactome Name: Ion influx/efflux at host-pathogen interface
See in Reactome
|
R-HSA-8953897
R-HSA-168249
R-HSA-983712
R-HSA-168256
R-HSA-2262752
R-HSA-382551
R-HSA-6803157
R-HSA-9711123
R-HSA-9711123
Reactome Name: Cellular response to chemical stress
See in Reactome
|
Cellular responses to stimuli
Immune System
Transport of small molecules
|
R-HSA-3697838
(
R-HSA-3299685
)
R-HSA-3697838
Reaction Name: ATP7A transfers Cu from ATOX1 to SOD3
See in Reactome
R-HSA-6803545
(
R-HSA-6803544
)
R-HSA-6803545
Reaction Name: ATP7A transports cytosolic Cu2+ to phagosomal lumen
See in Reactome
R-HSA-936802
(
R-HSA-936837
)
R-HSA-936802
Reaction Name: ATP7A transports cytosolic Cu2+ to extracellular region
See in Reactome
|
MONDO:0010389 |
CYBB |
P04839 |
1.-.-.-
|
R-HSA-1222556
R-HSA-1222556
Reactome Name: ROS and RNS production in phagocytes
See in Reactome
R-HSA-4420097
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-1236973
R-HSA-1236973
Reactome Name: Cross-presentation of particulate exogenous antigens (phagosomes)
See in Reactome
R-HSA-9013423
R-HSA-6798695
R-HSA-9013404
R-HSA-3299685
R-HSA-3299685
Reactome Name: Detoxification of Reactive Oxygen Species
See in Reactome
R-HSA-9013149
|
R-HSA-195258
R-HSA-8953897
R-HSA-9012999
R-HSA-194138
R-HSA-168256
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-194315
R-HSA-2262752
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-168249
R-HSA-9711123
R-HSA-9711123
Reactome Name: Cellular response to chemical stress
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-1280218
R-HSA-162582
|
Cellular responses to stimuli
Immune System
Signal Transduction
|
R-HSA-1222376
(
R-HSA-3299685
)
R-HSA-1222376
Reaction Name: NOX2 generates superoxide from oxygen
See in Reactome
R-HSA-1236967
(
R-HSA-1236973
)
R-HSA-1236967
Reaction Name: Alkalization of the phagosomal lumen by NOX2
See in Reactome
R-HSA-5218827
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218827
Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1
See in Reactome
R-HSA-5218841
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218841
Reaction Name: NADPH oxidase 2 generates superoxide from oxygen
See in Reactome
R-HSA-5668605
(
R-HSA-5668599
)
R-HSA-5668629
(
R-HSA-5668599
)
R-HSA-5668629
Reaction Name: Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP
See in Reactome
R-HSA-6789092
(
R-HSA-1222556
)
R-HSA-6789092
Reaction Name: NOX2 generates superoxide anion from oxygen
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-6799350
(
R-HSA-6798695
)
R-HSA-6799350
Reaction Name: Exocytosis of specific granule membrane proteins
See in Reactome
R-HSA-6807557
(
R-HSA-3299685
)
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014424
(
R-HSA-9013404
)
R-HSA-9014424
Reaction Name: RAC2 binds effectors at the phagocytic vesicle membrane
See in Reactome
R-HSA-9018808
(
R-HSA-9013423
)
R-HSA-9018808
Reaction Name: RAC3 binds effectors at the plasma membrane
See in Reactome
R-HSA-9626848
(
R-HSA-5668599
)
R-HSA-9626848
Reaction Name: S100A8:S100A9:AA:Ca(2+) binds NOX2 complex
See in Reactome
|
MONDO:0010572 |
ATP7A |
Q04656 |
7.2.2.8
|
R-HSA-936837
R-HSA-936837
Reactome Name: Ion transport by P-type ATPases
See in Reactome
R-HSA-3299685
R-HSA-3299685
Reactome Name: Detoxification of Reactive Oxygen Species
See in Reactome
R-HSA-6803544
R-HSA-6803544
Reactome Name: Ion influx/efflux at host-pathogen interface
See in Reactome
|
R-HSA-8953897
R-HSA-168249
R-HSA-983712
R-HSA-168256
R-HSA-2262752
R-HSA-382551
R-HSA-6803157
R-HSA-9711123
R-HSA-9711123
Reactome Name: Cellular response to chemical stress
See in Reactome
|
Cellular responses to stimuli
Immune System
Transport of small molecules
|
R-HSA-3697838
(
R-HSA-3299685
)
R-HSA-3697838
Reaction Name: ATP7A transfers Cu from ATOX1 to SOD3
See in Reactome
R-HSA-6803545
(
R-HSA-6803544
)
R-HSA-6803545
Reaction Name: ATP7A transports cytosolic Cu2+ to phagosomal lumen
See in Reactome
R-HSA-936802
(
R-HSA-936837
)
R-HSA-936802
Reaction Name: ATP7A transports cytosolic Cu2+ to extracellular region
See in Reactome
|
MONDO:0010600 |
CYBB |
P04839 |
1.-.-.-
|
R-HSA-1222556
R-HSA-1222556
Reactome Name: ROS and RNS production in phagocytes
See in Reactome
R-HSA-4420097
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-1236973
R-HSA-1236973
Reactome Name: Cross-presentation of particulate exogenous antigens (phagosomes)
See in Reactome
R-HSA-9013423
R-HSA-6798695
R-HSA-9013404
R-HSA-3299685
R-HSA-3299685
Reactome Name: Detoxification of Reactive Oxygen Species
See in Reactome
R-HSA-9013149
|
R-HSA-195258
R-HSA-8953897
R-HSA-9012999
R-HSA-194138
R-HSA-168256
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-194315
R-HSA-2262752
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-168249
R-HSA-9711123
R-HSA-9711123
Reactome Name: Cellular response to chemical stress
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-1280218
R-HSA-162582
|
Cellular responses to stimuli
Immune System
Signal Transduction
|
R-HSA-1222376
(
R-HSA-3299685
)
R-HSA-1222376
Reaction Name: NOX2 generates superoxide from oxygen
See in Reactome
R-HSA-1236967
(
R-HSA-1236973
)
R-HSA-1236967
Reaction Name: Alkalization of the phagosomal lumen by NOX2
See in Reactome
R-HSA-5218827
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218827
Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1
See in Reactome
R-HSA-5218841
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218841
Reaction Name: NADPH oxidase 2 generates superoxide from oxygen
See in Reactome
R-HSA-5668605
(
R-HSA-5668599
)
R-HSA-5668629
(
R-HSA-5668599
)
R-HSA-5668629
Reaction Name: Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP
See in Reactome
R-HSA-6789092
(
R-HSA-1222556
)
R-HSA-6789092
Reaction Name: NOX2 generates superoxide anion from oxygen
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-6799350
(
R-HSA-6798695
)
R-HSA-6799350
Reaction Name: Exocytosis of specific granule membrane proteins
See in Reactome
R-HSA-6807557
(
R-HSA-3299685
)
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014424
(
R-HSA-9013404
)
R-HSA-9014424
Reaction Name: RAC2 binds effectors at the phagocytic vesicle membrane
See in Reactome
R-HSA-9018808
(
R-HSA-9013423
)
R-HSA-9018808
Reaction Name: RAC3 binds effectors at the plasma membrane
See in Reactome
R-HSA-9626848
(
R-HSA-5668599
)
R-HSA-9626848
Reaction Name: S100A8:S100A9:AA:Ca(2+) binds NOX2 complex
See in Reactome
|
MONDO:0010651 |
ATP7A |
Q04656 |
7.2.2.8
|
R-HSA-936837
R-HSA-936837
Reactome Name: Ion transport by P-type ATPases
See in Reactome
R-HSA-3299685
R-HSA-3299685
Reactome Name: Detoxification of Reactive Oxygen Species
See in Reactome
R-HSA-6803544
R-HSA-6803544
Reactome Name: Ion influx/efflux at host-pathogen interface
See in Reactome
|
R-HSA-8953897
R-HSA-168249
R-HSA-983712
R-HSA-168256
R-HSA-2262752
R-HSA-382551
R-HSA-6803157
R-HSA-9711123
R-HSA-9711123
Reactome Name: Cellular response to chemical stress
See in Reactome
|
Cellular responses to stimuli
Immune System
Transport of small molecules
|
R-HSA-3697838
(
R-HSA-3299685
)
R-HSA-3697838
Reaction Name: ATP7A transfers Cu from ATOX1 to SOD3
See in Reactome
R-HSA-6803545
(
R-HSA-6803544
)
R-HSA-6803545
Reaction Name: ATP7A transports cytosolic Cu2+ to phagosomal lumen
See in Reactome
R-HSA-936802
(
R-HSA-936837
)
R-HSA-936802
Reaction Name: ATP7A transports cytosolic Cu2+ to extracellular region
See in Reactome
|
MONDO:0012970 |
SOD2 |
P04179 |
1.15.1.1
|
R-HSA-9615017
R-HSA-9615017
Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
See in Reactome
R-HSA-3299685
R-HSA-3299685
Reactome Name: Detoxification of Reactive Oxygen Species
See in Reactome
R-HSA-8950505
R-HSA-8950505
Reactome Name: Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
See in Reactome
R-HSA-2151201
R-HSA-2151201
Reactome Name: Transcriptional activation of mitochondrial biogenesis
See in Reactome
|
R-HSA-8953897
R-HSA-449147
R-HSA-212436
R-HSA-74160
R-HSA-1852241
R-HSA-1852241
Reactome Name: Organelle biogenesis and maintenance
See in Reactome
R-HSA-168256
R-HSA-2262752
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9614085
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-1592230
R-HSA-9711123
R-HSA-9711123
Reactome Name: Cellular response to chemical stress
See in Reactome
R-HSA-9020591
R-HSA-73857
|
Cellular responses to stimuli
Gene expression (Transcription)
Organelle biogenesis and maintenance
Immune System
|
R-HSA-3299680
(
R-HSA-3299685
)
R-HSA-3299680
Reaction Name: SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)
See in Reactome
R-HSA-5688289
(
R-HSA-2151201
)
R-HSA-5688289
Reaction Name: SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2
See in Reactome
R-HSA-9617833
(
R-HSA-9615017
)
R-HSA-9617833
Reaction Name: SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1
See in Reactome
R-HSA-9617941
(
R-HSA-8950505
)
R-HSA-9617941
Reaction Name: Expression of superoxide dismutase 2
See in Reactome
|
MONDO:0013571 |
CAT |
P04040 |
1.11.1.6
|
R-HSA-6798695
R-HSA-9615017
R-HSA-9615017
Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
See in Reactome
R-HSA-3299685
R-HSA-3299685
Reactome Name: Detoxification of Reactive Oxygen Species
See in Reactome
R-HSA-9033241
|
R-HSA-8953897
R-HSA-9609507
R-HSA-9614085
R-HSA-168256
R-HSA-168249
R-HSA-2262752
R-HSA-212436
R-HSA-9711123
R-HSA-9711123
Reactome Name: Cellular response to chemical stress
See in Reactome
R-HSA-74160
R-HSA-73857
|
Cellular responses to stimuli
Protein localization
Immune System
Gene expression (Transcription)
|
R-HSA-6798748
(
R-HSA-6798695
)
R-HSA-6798748
Reaction Name: Exocytosis of secretory granule lumen proteins
See in Reactome
R-HSA-6800434
(
R-HSA-6798695
)
R-HSA-6800434
Reaction Name: Exocytosis of ficolin-rich granule lumen proteins
See in Reactome
R-HSA-76031
(
R-HSA-3299685
)
R-HSA-9033233
(
R-HSA-9033241
)
R-HSA-9033233
(
R-HSA-9033241
)
R-HSA-9033233
Reaction Name: PEX5S,L binds cargo proteins containing PTS1
See in Reactome
R-HSA-9033235
(
R-HSA-9033241
)
R-HSA-9033235
(
R-HSA-9033241
)
R-HSA-9033235
Reaction Name: Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix
See in Reactome
R-HSA-9033236
(
R-HSA-9033241
)
R-HSA-9033236
(
R-HSA-9033241
)
R-HSA-9033236
Reaction Name: PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)
See in Reactome
R-HSA-9622738
(
R-HSA-9615017
)
R-HSA-9622738
Reaction Name: CAT gene expression is stimulated by FOXO3,FOXO6,(FOXO1)
See in Reactome
|
MONDO:0013601 |
GPX1 |
P07203 |
1.11.1.9
|
R-HSA-2142712
R-HSA-2142712
Reactome Name: Synthesis of 12-eicosatetraenoic acid derivatives
See in Reactome
R-HSA-3299685
R-HSA-3299685
Reactome Name: Detoxification of Reactive Oxygen Species
See in Reactome
R-HSA-2142770
R-HSA-2142770
Reactome Name: Synthesis of 15-eicosatetraenoic acid derivatives
See in Reactome
R-HSA-2142688
R-HSA-2142688
Reactome Name: Synthesis of 5-eicosatetraenoic acids
See in Reactome
|
R-HSA-8953897
R-HSA-2262752
R-HSA-1430728
R-HSA-8978868
R-HSA-2142753
R-HSA-556833
R-HSA-9711123
R-HSA-9711123
Reactome Name: Cellular response to chemical stress
See in Reactome
|
Cellular responses to stimuli
Metabolism
|
R-HSA-2161791
(
R-HSA-2142770
)
R-HSA-2161791
Reaction Name: 15S-HpETE is reduced to 15S-HETE by GPX1/2/4
See in Reactome
R-HSA-2161946
(
R-HSA-2142688
)
R-HSA-2161946
Reaction Name: 5S-HpETE is reduced to 5S-HETE by GPX1/2/4
See in Reactome
R-HSA-2161959
(
R-HSA-2142712
)
R-HSA-2161959
Reaction Name: 12R-HpETE is reduced to 12R-HETE by GPX1/2/4
See in Reactome
R-HSA-2161999
(
R-HSA-2142712
)
R-HSA-2161999
Reaction Name: 12S-HpETE is reduced to 12S-HETE by GPX1/2/4
See in Reactome
R-HSA-3323013
(
R-HSA-3299685
)
R-HSA-3323013
Reaction Name: GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
See in Reactome
R-HSA-71676
(
R-HSA-3299685
)
R-HSA-71676
Reaction Name: GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O
See in Reactome
|
MONDO:0013662 |
GPX7 |
Q96SL4 |
1.11.1.9
|
R-HSA-3299685
R-HSA-3299685
Reactome Name: Detoxification of Reactive Oxygen Species
See in Reactome
|
R-HSA-8953897
R-HSA-9711123
R-HSA-9711123
Reactome Name: Cellular response to chemical stress
See in Reactome
R-HSA-2262752
|
Cellular responses to stimuli
|
R-HSA-3341296
(
R-HSA-3299685
)
R-HSA-3341296
Reaction Name: GPX7,8 catalyze peroxidation of P4HB (PDI)
See in Reactome
|
MONDO:0015470 |
TXNRD2 |
Q9NNW7 |
1.8.1.9
|
R-HSA-3299685
R-HSA-3299685
Reactome Name: Detoxification of Reactive Oxygen Species
See in Reactome
|
R-HSA-8953897
R-HSA-9711123
R-HSA-9711123
Reactome Name: Cellular response to chemical stress
See in Reactome
R-HSA-2262752
|
Cellular responses to stimuli
|
R-HSA-3323050
(
R-HSA-3299685
)
R-HSA-3323050
Reaction Name: TXNRD2 catalyzes the reduction of TXN2 by NADPH
See in Reactome
|
MONDO:0015626 |
ATP7A |
Q04656 |
7.2.2.8
|
R-HSA-936837
R-HSA-936837
Reactome Name: Ion transport by P-type ATPases
See in Reactome
R-HSA-3299685
R-HSA-3299685
Reactome Name: Detoxification of Reactive Oxygen Species
See in Reactome
R-HSA-6803544
R-HSA-6803544
Reactome Name: Ion influx/efflux at host-pathogen interface
See in Reactome
|
R-HSA-8953897
R-HSA-168249
R-HSA-983712
R-HSA-168256
R-HSA-2262752
R-HSA-382551
R-HSA-6803157
R-HSA-9711123
R-HSA-9711123
Reactome Name: Cellular response to chemical stress
See in Reactome
|
Cellular responses to stimuli
Immune System
Transport of small molecules
|
R-HSA-3697838
(
R-HSA-3299685
)
R-HSA-3697838
Reaction Name: ATP7A transfers Cu from ATOX1 to SOD3
See in Reactome
R-HSA-6803545
(
R-HSA-6803544
)
R-HSA-6803545
Reaction Name: ATP7A transports cytosolic Cu2+ to phagosomal lumen
See in Reactome
R-HSA-936802
(
R-HSA-936837
)
R-HSA-936802
Reaction Name: ATP7A transports cytosolic Cu2+ to extracellular region
See in Reactome
|
MONDO:0018309 |
ATP7A |
Q04656 |
7.2.2.8
|
R-HSA-936837
R-HSA-936837
Reactome Name: Ion transport by P-type ATPases
See in Reactome
R-HSA-3299685
R-HSA-3299685
Reactome Name: Detoxification of Reactive Oxygen Species
See in Reactome
R-HSA-6803544
R-HSA-6803544
Reactome Name: Ion influx/efflux at host-pathogen interface
See in Reactome
|
R-HSA-8953897
R-HSA-168249
R-HSA-983712
R-HSA-168256
R-HSA-2262752
R-HSA-382551
R-HSA-6803157
R-HSA-9711123
R-HSA-9711123
Reactome Name: Cellular response to chemical stress
See in Reactome
|
Cellular responses to stimuli
Immune System
Transport of small molecules
|
R-HSA-3697838
(
R-HSA-3299685
)
R-HSA-3697838
Reaction Name: ATP7A transfers Cu from ATOX1 to SOD3
See in Reactome
R-HSA-6803545
(
R-HSA-6803544
)
R-HSA-6803545
Reaction Name: ATP7A transports cytosolic Cu2+ to phagosomal lumen
See in Reactome
R-HSA-936802
(
R-HSA-936837
)
R-HSA-936802
Reaction Name: ATP7A transports cytosolic Cu2+ to extracellular region
See in Reactome
|
MONDO:0019531 |
GSR |
P00390 |
1.8.1.7
|
R-HSA-499943
R-HSA-499943
Reactome Name: Interconversion of nucleotide di- and triphosphates
See in Reactome
R-HSA-3299685
R-HSA-3299685
Reactome Name: Detoxification of Reactive Oxygen Species
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-2408550
R-HSA-2408550
Reactome Name: Metabolism of ingested H2SeO4 and H2SeO3 into H2Se
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-8953897
R-HSA-212436
R-HSA-71291
R-HSA-71291
Reactome Name: Metabolism of amino acids and derivatives
See in Reactome
R-HSA-2262752
R-HSA-1430728
R-HSA-9711123
R-HSA-9711123
Reactome Name: Cellular response to chemical stress
See in Reactome
R-HSA-74160
R-HSA-15869
R-HSA-2408522
R-HSA-73857
|
Cellular responses to stimuli
Metabolism
Gene expression (Transcription)
|
R-HSA-2408542
(
R-HSA-2408550
)
R-HSA-2408542
Reaction Name: GSSeSG is reduced to GSSeH and GSH by GSR
See in Reactome
R-HSA-3323079
(
R-HSA-3299685
)
R-HSA-3323079
Reaction Name: GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+
See in Reactome
R-HSA-71682
(
R-HSA-3299685;
R-HSA-499943;
R-HSA-5628897
)
R-HSA-71682
Reaction Name: glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+
See in Reactome
R-HSA-9761843
()
R-HSA-9761843
Reaction Name: NFE2L2-dependent GSR gene expression
See in Reactome
|
MONDO:0032828 |
SOD1 |
P00441 |
1.15.1.1
|
R-HSA-3299685
R-HSA-3299685
Reactome Name: Detoxification of Reactive Oxygen Species
See in Reactome
R-HSA-8950505
R-HSA-8950505
Reactome Name: Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
See in Reactome
R-HSA-114608
|
R-HSA-8953897
R-HSA-449147
R-HSA-447115
R-HSA-447115
Reactome Name: Interleukin-12 family signaling
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-168256
R-HSA-2262752
R-HSA-76005
R-HSA-76005
Reactome Name: Response to elevated platelet cytosolic Ca2+
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9711123
R-HSA-9711123
Reactome Name: Cellular response to chemical stress
See in Reactome
R-HSA-9020591
R-HSA-109582
|
Cellular responses to stimuli
Immune System
Hemostasis
|
R-HSA-3299691
(
R-HSA-3299685
)
R-HSA-3299691
Reaction Name: SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)
See in Reactome
R-HSA-3299753
(
R-HSA-3299685
)
R-HSA-3299753
Reaction Name: CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1
See in Reactome
R-HSA-3697860
(
R-HSA-3299685
)
R-HSA-3697860
Reaction Name: SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+
See in Reactome
R-HSA-3777112
(
R-HSA-3299685
)
R-HSA-3777112
Reaction Name: SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)
See in Reactome
R-HSA-3780958
(
R-HSA-3299685
)
R-HSA-3780958
Reaction Name: SOD1:Zn2+ apoenzyme binds CCS:Cu1+ (mitochondrial)
See in Reactome
R-HSA-3780979
(
R-HSA-3299685
)
R-HSA-3780979
Reaction Name: CCS transfers Cu to SOD1 (mitochondrial)
See in Reactome
R-HSA-482772
(
R-HSA-114608
)
R-HSA-482772
Reaction Name: Release of platelet cytosolic components
See in Reactome
R-HSA-8950771
(
R-HSA-8950505
)
R-HSA-8951723
(
R-HSA-3299685
)
R-HSA-8951723
Reaction Name: 2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates
See in Reactome
|
MONDO:0040502 |
TXNRD2 |
Q9NNW7 |
1.8.1.9
|
R-HSA-3299685
R-HSA-3299685
Reactome Name: Detoxification of Reactive Oxygen Species
See in Reactome
|
R-HSA-8953897
R-HSA-9711123
R-HSA-9711123
Reactome Name: Cellular response to chemical stress
See in Reactome
R-HSA-2262752
|
Cellular responses to stimuli
|
R-HSA-3323050
(
R-HSA-3299685
)
R-HSA-3323050
Reaction Name: TXNRD2 catalyzes the reduction of TXN2 by NADPH
See in Reactome
|