DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-3299685)

Number of enzymes:	11
Number of disease:	19
Number of reactomes:	31
Number of reactions:	67

Search results (Reactome ID: R-HSA-3299685)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007103	SOD1	P00441	1.15.1.1	R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-8950505 R-HSA-8950505 Reactome Name: Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Cellular responses to stimuli Immune System Hemostasis	R-HSA-3299691 ( R-HSA-3299685 ) R-HSA-3299691 Reaction Name: SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) See in Reactome R-HSA-3299753 ( R-HSA-3299685 ) R-HSA-3299753 Reaction Name: CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 See in Reactome R-HSA-3697860 ( R-HSA-3299685 ) R-HSA-3697860 Reaction Name: SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ See in Reactome R-HSA-3777112 ( R-HSA-3299685 ) R-HSA-3777112 Reaction Name: SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) See in Reactome R-HSA-3780958 ( R-HSA-3299685 ) R-HSA-3780958 Reaction Name: SOD1:Zn2+ apoenzyme binds CCS:Cu1+ (mitochondrial) See in Reactome R-HSA-3780979 ( R-HSA-3299685 ) R-HSA-3780979 Reaction Name: CCS transfers Cu to SOD1 (mitochondrial) See in Reactome R-HSA-482772 ( R-HSA-114608 ) R-HSA-482772 Reaction Name: Release of platelet cytosolic components See in Reactome R-HSA-8950771 ( R-HSA-8950505; R-HSA-9020591 ) R-HSA-8950771 Reaction Name: Expression of SOD1 See in Reactome R-HSA-8951723 ( R-HSA-3299685 ) R-HSA-8951723 Reaction Name: 2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates See in Reactome
MONDO:0007204	P4HB	P07237	5.3.4.1	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-8963888 R-HSA-8963888 Reactome Name: Chylomicron assembly See in Reactome R-HSA-8964041 R-HSA-8964041 Reactome Name: LDL remodeling See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-8866423 R-HSA-8866423 Reactome Name: VLDL assembly See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome	R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8963898 R-HSA-8963898 Reactome Name: Plasma lipoprotein assembly See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome	Cellular responses to stimuli Immune System Transport of small molecules Extracellular matrix organization Metabolism of proteins Signal Transduction	R-HSA-1650808 ( R-HSA-1650814 ) R-HSA-1650808 Reaction Name: Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines See in Reactome R-HSA-174741 ( R-HSA-8963888 ) R-HSA-174741 Reaction Name: ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron See in Reactome R-HSA-174786 ( R-HSA-8963888 ) R-HSA-174786 Reaction Name: ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex See in Reactome R-HSA-2002460 ( R-HSA-1650814 ) R-HSA-2002460 Reaction Name: P4HB binds Collagen chains See in Reactome R-HSA-3341296 ( R-HSA-3299685 ) R-HSA-3341296 Reaction Name: GPX7,8 catalyze peroxidation of P4HB (PDI) See in Reactome R-HSA-5358336 ( R-HSA-5358346 ) R-HSA-5358336 Reaction Name: P4HB forms mixed disulphides with Hh precursors See in Reactome R-HSA-5358340 ( R-HSA-5358346 ) R-HSA-5358340 Reaction Name: Autoproteolytic cleavage of Hh precursors See in Reactome R-HSA-8866329 ( R-HSA-8866423 ) R-HSA-8866329 Reaction Name: MTTP lipidates APOB-100, forming a pre-VLDL See in Reactome R-HSA-8948234 ( R-HSA-1650814 ) R-HSA-8948234 Reaction Name: P4HB:4-Hyp collagen propeptides dissociates See in Reactome R-HSA-8950113 ( R-HSA-9020591 ) R-HSA-8950113 Reaction Name: IL12A binds IL12B See in Reactome R-HSA-8950183 ( R-HSA-9020933 ) R-HSA-8950183 Reaction Name: IL12B binds IL23A See in Reactome R-HSA-8950456 ( R-HSA-9020591 ) R-HSA-8950456 Reaction Name: IL12B dimerizes See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome R-HSA-9737780 ( R-HSA-8964041 ) R-HSA-9737780 Reaction Name: MTTP binds lomitapide See in Reactome
MONDO:0008146	P4HB	P07237	5.3.4.1	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-8963888 R-HSA-8963888 Reactome Name: Chylomicron assembly See in Reactome R-HSA-8964041 R-HSA-8964041 Reactome Name: LDL remodeling See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-8866423 R-HSA-8866423 Reactome Name: VLDL assembly See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome	R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8963898 R-HSA-8963898 Reactome Name: Plasma lipoprotein assembly See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome	Cellular responses to stimuli Immune System Transport of small molecules Extracellular matrix organization Metabolism of proteins Signal Transduction	R-HSA-1650808 ( R-HSA-1650814 ) R-HSA-1650808 Reaction Name: Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines See in Reactome R-HSA-174741 ( R-HSA-8963888 ) R-HSA-174741 Reaction Name: ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron See in Reactome R-HSA-174786 ( R-HSA-8963888 ) R-HSA-174786 Reaction Name: ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex See in Reactome R-HSA-2002460 ( R-HSA-1650814 ) R-HSA-2002460 Reaction Name: P4HB binds Collagen chains See in Reactome R-HSA-3341296 ( R-HSA-3299685 ) R-HSA-3341296 Reaction Name: GPX7,8 catalyze peroxidation of P4HB (PDI) See in Reactome R-HSA-5358336 ( R-HSA-5358346 ) R-HSA-5358336 Reaction Name: P4HB forms mixed disulphides with Hh precursors See in Reactome R-HSA-5358340 ( R-HSA-5358346 ) R-HSA-5358340 Reaction Name: Autoproteolytic cleavage of Hh precursors See in Reactome R-HSA-8866329 ( R-HSA-8866423 ) R-HSA-8866329 Reaction Name: MTTP lipidates APOB-100, forming a pre-VLDL See in Reactome R-HSA-8948234 ( R-HSA-1650814 ) R-HSA-8948234 Reaction Name: P4HB:4-Hyp collagen propeptides dissociates See in Reactome R-HSA-8950113 ( R-HSA-9020591 ) R-HSA-8950113 Reaction Name: IL12A binds IL12B See in Reactome R-HSA-8950183 ( R-HSA-9020933 ) R-HSA-8950183 Reaction Name: IL12B binds IL23A See in Reactome R-HSA-8950456 ( R-HSA-9020591 ) R-HSA-8950456 Reaction Name: IL12B dimerizes See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome R-HSA-9737780 ( R-HSA-8964041 ) R-HSA-9737780 Reaction Name: MTTP binds lomitapide See in Reactome
MONDO:0010184	PRDX1	Q06830	1.11.1.24	R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Cellular responses to stimuli Gene expression (Transcription)	R-HSA-3341343 ( R-HSA-3299685; R-HSA-5628897 ) R-HSA-3341343 Reaction Name: PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O See in Reactome R-HSA-5631885 ( R-HSA-5628897 ) R-HSA-5631885 Reaction Name: PRDX1 overoxidizes See in Reactome R-HSA-5631903 ( R-HSA-5628897 ) R-HSA-5631903 Reaction Name: SESN1,2,3 bind overoxidized PRDX1 See in Reactome R-HSA-9759189 () R-HSA-9759189 Reaction Name: NFE2L2-dependent PRDX1 gene expression See in Reactome R-HSA-9760094 () R-HSA-9760094 Reaction Name: SRXN1 reduces hyperoxidized PRDX1 dimer See in Reactome
MONDO:0010338	ATP7A	Q04656	7.2.2.8	R-HSA-936837 R-HSA-936837 Reactome Name: Ion transport by P-type ATPases See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-6803544 R-HSA-6803544 Reactome Name: Ion influx/efflux at host-pathogen interface See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-983712 R-HSA-983712 Reactome Name: Ion channel transport See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-6803157 R-HSA-6803157 Reactome Name: Antimicrobial peptides See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome	Cellular responses to stimuli Immune System Transport of small molecules	R-HSA-3697838 ( R-HSA-3299685 ) R-HSA-3697838 Reaction Name: ATP7A transfers Cu from ATOX1 to SOD3 See in Reactome R-HSA-6803545 ( R-HSA-6803544 ) R-HSA-6803545 Reaction Name: ATP7A transports cytosolic Cu2+ to phagosomal lumen See in Reactome R-HSA-936802 ( R-HSA-936837 ) R-HSA-936802 Reaction Name: ATP7A transports cytosolic Cu2+ to extracellular region See in Reactome
MONDO:0010389	CYBB	P04839	1.-.-.-	R-HSA-1222556 R-HSA-1222556 Reactome Name: ROS and RNS production in phagocytes See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-1236973 R-HSA-1236973 Reactome Name: Cross-presentation of particulate exogenous antigens (phagosomes) See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome	R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cellular responses to stimuli Immune System Signal Transduction	R-HSA-1222376 ( R-HSA-3299685 ) R-HSA-1222376 Reaction Name: NOX2 generates superoxide from oxygen See in Reactome R-HSA-1236967 ( R-HSA-1236973 ) R-HSA-1236967 Reaction Name: Alkalization of the phagosomal lumen by NOX2 See in Reactome R-HSA-5218827 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218827 Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1 See in Reactome R-HSA-5218841 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218841 Reaction Name: NADPH oxidase 2 generates superoxide from oxygen See in Reactome R-HSA-5668605 ( R-HSA-5668599 ) R-HSA-5668605 Reaction Name: RAC2:GTP binds NOX2 complex See in Reactome R-HSA-5668629 ( R-HSA-5668599 ) R-HSA-5668629 Reaction Name: Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP See in Reactome R-HSA-6789092 ( R-HSA-1222556 ) R-HSA-6789092 Reaction Name: NOX2 generates superoxide anion from oxygen See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-6799350 ( R-HSA-6798695 ) R-HSA-6799350 Reaction Name: Exocytosis of specific granule membrane proteins See in Reactome R-HSA-6807557 ( R-HSA-3299685 ) R-HSA-6807557 Reaction Name: NOX4, NOX5 reduce O2 to O2.- See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014424 ( R-HSA-9013404 ) R-HSA-9014424 Reaction Name: RAC2 binds effectors at the phagocytic vesicle membrane See in Reactome R-HSA-9018808 ( R-HSA-9013423 ) R-HSA-9018808 Reaction Name: RAC3 binds effectors at the plasma membrane See in Reactome R-HSA-9626848 ( R-HSA-5668599 ) R-HSA-9626848 Reaction Name: S100A8:S100A9:AA:Ca(2+) binds NOX2 complex See in Reactome
MONDO:0010572	ATP7A	Q04656	7.2.2.8	R-HSA-936837 R-HSA-936837 Reactome Name: Ion transport by P-type ATPases See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-6803544 R-HSA-6803544 Reactome Name: Ion influx/efflux at host-pathogen interface See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-983712 R-HSA-983712 Reactome Name: Ion channel transport See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-6803157 R-HSA-6803157 Reactome Name: Antimicrobial peptides See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome	Cellular responses to stimuli Immune System Transport of small molecules	R-HSA-3697838 ( R-HSA-3299685 ) R-HSA-3697838 Reaction Name: ATP7A transfers Cu from ATOX1 to SOD3 See in Reactome R-HSA-6803545 ( R-HSA-6803544 ) R-HSA-6803545 Reaction Name: ATP7A transports cytosolic Cu2+ to phagosomal lumen See in Reactome R-HSA-936802 ( R-HSA-936837 ) R-HSA-936802 Reaction Name: ATP7A transports cytosolic Cu2+ to extracellular region See in Reactome
MONDO:0010600	CYBB	P04839	1.-.-.-	R-HSA-1222556 R-HSA-1222556 Reactome Name: ROS and RNS production in phagocytes See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-1236973 R-HSA-1236973 Reactome Name: Cross-presentation of particulate exogenous antigens (phagosomes) See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome	R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cellular responses to stimuli Immune System Signal Transduction	R-HSA-1222376 ( R-HSA-3299685 ) R-HSA-1222376 Reaction Name: NOX2 generates superoxide from oxygen See in Reactome R-HSA-1236967 ( R-HSA-1236973 ) R-HSA-1236967 Reaction Name: Alkalization of the phagosomal lumen by NOX2 See in Reactome R-HSA-5218827 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218827 Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1 See in Reactome R-HSA-5218841 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218841 Reaction Name: NADPH oxidase 2 generates superoxide from oxygen See in Reactome R-HSA-5668605 ( R-HSA-5668599 ) R-HSA-5668605 Reaction Name: RAC2:GTP binds NOX2 complex See in Reactome R-HSA-5668629 ( R-HSA-5668599 ) R-HSA-5668629 Reaction Name: Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP See in Reactome R-HSA-6789092 ( R-HSA-1222556 ) R-HSA-6789092 Reaction Name: NOX2 generates superoxide anion from oxygen See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-6799350 ( R-HSA-6798695 ) R-HSA-6799350 Reaction Name: Exocytosis of specific granule membrane proteins See in Reactome R-HSA-6807557 ( R-HSA-3299685 ) R-HSA-6807557 Reaction Name: NOX4, NOX5 reduce O2 to O2.- See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014424 ( R-HSA-9013404 ) R-HSA-9014424 Reaction Name: RAC2 binds effectors at the phagocytic vesicle membrane See in Reactome R-HSA-9018808 ( R-HSA-9013423 ) R-HSA-9018808 Reaction Name: RAC3 binds effectors at the plasma membrane See in Reactome R-HSA-9626848 ( R-HSA-5668599 ) R-HSA-9626848 Reaction Name: S100A8:S100A9:AA:Ca(2+) binds NOX2 complex See in Reactome
MONDO:0010651	ATP7A	Q04656	7.2.2.8	R-HSA-936837 R-HSA-936837 Reactome Name: Ion transport by P-type ATPases See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-6803544 R-HSA-6803544 Reactome Name: Ion influx/efflux at host-pathogen interface See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-983712 R-HSA-983712 Reactome Name: Ion channel transport See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-6803157 R-HSA-6803157 Reactome Name: Antimicrobial peptides See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome	Cellular responses to stimuli Immune System Transport of small molecules	R-HSA-3697838 ( R-HSA-3299685 ) R-HSA-3697838 Reaction Name: ATP7A transfers Cu from ATOX1 to SOD3 See in Reactome R-HSA-6803545 ( R-HSA-6803544 ) R-HSA-6803545 Reaction Name: ATP7A transports cytosolic Cu2+ to phagosomal lumen See in Reactome R-HSA-936802 ( R-HSA-936837 ) R-HSA-936802 Reaction Name: ATP7A transports cytosolic Cu2+ to extracellular region See in Reactome
MONDO:0012970	SOD2	P04179	1.15.1.1	R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-8950505 R-HSA-8950505 Reactome Name: Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation See in Reactome R-HSA-2151201 R-HSA-2151201 Reactome Name: Transcriptional activation of mitochondrial biogenesis See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-1592230 R-HSA-1592230 Reactome Name: Mitochondrial biogenesis See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Cellular responses to stimuli Gene expression (Transcription) Organelle biogenesis and maintenance Immune System	R-HSA-3299680 ( R-HSA-3299685 ) R-HSA-3299680 Reaction Name: SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) See in Reactome R-HSA-5688289 ( R-HSA-2151201 ) R-HSA-5688289 Reaction Name: SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 See in Reactome R-HSA-9617833 ( R-HSA-9615017 ) R-HSA-9617833 Reaction Name: SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1 See in Reactome R-HSA-9617941 ( R-HSA-8950505; R-HSA-9020591 ) R-HSA-9617941 Reaction Name: Expression of superoxide dismutase 2 See in Reactome
MONDO:0013571	CAT	P04040	1.11.1.6	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-9033241 R-HSA-9033241 Reactome Name: Peroxisomal protein import See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Cellular responses to stimuli Protein localization Immune System Gene expression (Transcription)	R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-76031 ( R-HSA-3299685 ) R-HSA-76031 Reaction Name: 2 H2O2 => O2 + 2 H2O See in Reactome R-HSA-9033233 ( R-HSA-9033241 ) R-HSA-9033233 Reaction Name: PEX5S See in Reactome R-HSA-9033233 ( R-HSA-9033241 ) R-HSA-9033233 Reaction Name: PEX5S,L binds cargo proteins containing PTS1 See in Reactome R-HSA-9033235 ( R-HSA-9033241 ) R-HSA-9033235 Reaction Name: Cargo of PEX5S See in Reactome R-HSA-9033235 ( R-HSA-9033241 ) R-HSA-9033235 Reaction Name: Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix See in Reactome R-HSA-9033236 ( R-HSA-9033241 ) R-HSA-9033236 Reaction Name: PEX5S See in Reactome R-HSA-9033236 ( R-HSA-9033241 ) R-HSA-9033236 Reaction Name: PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) See in Reactome R-HSA-9622738 ( R-HSA-9615017 ) R-HSA-9622738 Reaction Name: CAT gene expression is stimulated by FOXO3,FOXO6,(FOXO1) See in Reactome
MONDO:0013601	GPX1	P07203	1.11.1.9	R-HSA-2142712 R-HSA-2142712 Reactome Name: Synthesis of 12-eicosatetraenoic acid derivatives See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-2142770 R-HSA-2142770 Reactome Name: Synthesis of 15-eicosatetraenoic acid derivatives See in Reactome R-HSA-2142688 R-HSA-2142688 Reactome Name: Synthesis of 5-eicosatetraenoic acids See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome	Cellular responses to stimuli Metabolism	R-HSA-2161791 ( R-HSA-2142770 ) R-HSA-2161791 Reaction Name: 15S-HpETE is reduced to 15S-HETE by GPX1/2/4 See in Reactome R-HSA-2161946 ( R-HSA-2142688 ) R-HSA-2161946 Reaction Name: 5S-HpETE is reduced to 5S-HETE by GPX1/2/4 See in Reactome R-HSA-2161959 ( R-HSA-2142712 ) R-HSA-2161959 Reaction Name: 12R-HpETE is reduced to 12R-HETE by GPX1/2/4 See in Reactome R-HSA-2161999 ( R-HSA-2142712 ) R-HSA-2161999 Reaction Name: 12S-HpETE is reduced to 12S-HETE by GPX1/2/4 See in Reactome R-HSA-3323013 ( R-HSA-3299685 ) R-HSA-3323013 Reaction Name: GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O See in Reactome R-HSA-71676 ( R-HSA-3299685 ) R-HSA-71676 Reaction Name: GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O See in Reactome
MONDO:0013662	GPX7	Q96SL4	1.11.1.9	R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome	Cellular responses to stimuli	R-HSA-3341296 ( R-HSA-3299685 ) R-HSA-3341296 Reaction Name: GPX7,8 catalyze peroxidation of P4HB (PDI) See in Reactome
MONDO:0015470	TXNRD2	Q9NNW7	1.8.1.9	R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome	Cellular responses to stimuli	R-HSA-3323050 ( R-HSA-3299685 ) R-HSA-3323050 Reaction Name: TXNRD2 catalyzes the reduction of TXN2 by NADPH See in Reactome
MONDO:0015626	ATP7A	Q04656	7.2.2.8	R-HSA-936837 R-HSA-936837 Reactome Name: Ion transport by P-type ATPases See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-6803544 R-HSA-6803544 Reactome Name: Ion influx/efflux at host-pathogen interface See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-983712 R-HSA-983712 Reactome Name: Ion channel transport See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-6803157 R-HSA-6803157 Reactome Name: Antimicrobial peptides See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome	Cellular responses to stimuli Immune System Transport of small molecules	R-HSA-3697838 ( R-HSA-3299685 ) R-HSA-3697838 Reaction Name: ATP7A transfers Cu from ATOX1 to SOD3 See in Reactome R-HSA-6803545 ( R-HSA-6803544 ) R-HSA-6803545 Reaction Name: ATP7A transports cytosolic Cu2+ to phagosomal lumen See in Reactome R-HSA-936802 ( R-HSA-936837 ) R-HSA-936802 Reaction Name: ATP7A transports cytosolic Cu2+ to extracellular region See in Reactome
MONDO:0018309	ATP7A	Q04656	7.2.2.8	R-HSA-936837 R-HSA-936837 Reactome Name: Ion transport by P-type ATPases See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-6803544 R-HSA-6803544 Reactome Name: Ion influx/efflux at host-pathogen interface See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-983712 R-HSA-983712 Reactome Name: Ion channel transport See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-6803157 R-HSA-6803157 Reactome Name: Antimicrobial peptides See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome	Cellular responses to stimuli Immune System Transport of small molecules	R-HSA-3697838 ( R-HSA-3299685 ) R-HSA-3697838 Reaction Name: ATP7A transfers Cu from ATOX1 to SOD3 See in Reactome R-HSA-6803545 ( R-HSA-6803544 ) R-HSA-6803545 Reaction Name: ATP7A transports cytosolic Cu2+ to phagosomal lumen See in Reactome R-HSA-936802 ( R-HSA-936837 ) R-HSA-936802 Reaction Name: ATP7A transports cytosolic Cu2+ to extracellular region See in Reactome
MONDO:0019531	GSR	P00390	1.8.1.7	R-HSA-499943 R-HSA-499943 Reactome Name: Interconversion of nucleotide di- and triphosphates See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-2408550 R-HSA-2408550 Reactome Name: Metabolism of ingested H2SeO4 and H2SeO3 into H2Se See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-15869 R-HSA-15869 Reactome Name: Metabolism of nucleotides See in Reactome R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Cellular responses to stimuli Metabolism Gene expression (Transcription)	R-HSA-2408542 ( R-HSA-2408550 ) R-HSA-2408542 Reaction Name: GSSeSG is reduced to GSSeH and GSH by GSR See in Reactome R-HSA-3323079 ( R-HSA-3299685 ) R-HSA-3323079 Reaction Name: GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ See in Reactome R-HSA-71682 ( R-HSA-3299685; R-HSA-499943; R-HSA-5628897 ) R-HSA-71682 Reaction Name: glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ See in Reactome R-HSA-9761843 () R-HSA-9761843 Reaction Name: NFE2L2-dependent GSR gene expression See in Reactome
MONDO:0032828	SOD1	P00441	1.15.1.1	R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-8950505 R-HSA-8950505 Reactome Name: Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Cellular responses to stimuli Immune System Hemostasis	R-HSA-3299691 ( R-HSA-3299685 ) R-HSA-3299691 Reaction Name: SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) See in Reactome R-HSA-3299753 ( R-HSA-3299685 ) R-HSA-3299753 Reaction Name: CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 See in Reactome R-HSA-3697860 ( R-HSA-3299685 ) R-HSA-3697860 Reaction Name: SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ See in Reactome R-HSA-3777112 ( R-HSA-3299685 ) R-HSA-3777112 Reaction Name: SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) See in Reactome R-HSA-3780958 ( R-HSA-3299685 ) R-HSA-3780958 Reaction Name: SOD1:Zn2+ apoenzyme binds CCS:Cu1+ (mitochondrial) See in Reactome R-HSA-3780979 ( R-HSA-3299685 ) R-HSA-3780979 Reaction Name: CCS transfers Cu to SOD1 (mitochondrial) See in Reactome R-HSA-482772 ( R-HSA-114608 ) R-HSA-482772 Reaction Name: Release of platelet cytosolic components See in Reactome R-HSA-8950771 ( R-HSA-8950505; R-HSA-9020591 ) R-HSA-8950771 Reaction Name: Expression of SOD1 See in Reactome R-HSA-8951723 ( R-HSA-3299685 ) R-HSA-8951723 Reaction Name: 2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates See in Reactome
MONDO:0040502	TXNRD2	Q9NNW7	1.8.1.9	R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome	Cellular responses to stimuli	R-HSA-3323050 ( R-HSA-3299685 ) R-HSA-3323050 Reaction Name: TXNRD2 catalyzes the reduction of TXN2 by NADPH See in Reactome