DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-3270619)

Number of enzymes:	5
Number of disease:	12
Number of reactomes:	30
Number of reactions:	137

Search results (Reactome ID: R-HSA-3270619)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007915	TREX1	Q9NSU2	3.1.11.2	R-HSA-3270619 R-HSA-3270619 Reactome Name: IRF3-mediated induction of type I IFN See in Reactome R-HSA-3248023 R-HSA-3248023 Reactome Name: Regulation by TREX1 See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1834941 R-HSA-1834941 Reactome Name: STING mediated induction of host immune responses See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-3134975 R-HSA-3134975 Reactome Name: Regulation of innate immune responses to cytosolic DNA See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome	Immune System	R-HSA-1834939 ( R-HSA-1834949; R-HSA-3270619 ) R-HSA-1834939 Reaction Name: STING recruits TBK1 and IRF3 See in Reactome R-HSA-3244605 ( R-HSA-1834949; R-HSA-3248023 ) R-HSA-3244605 Reaction Name: TREX1 binds retroviral-derived DNA See in Reactome R-HSA-3245943 ( R-HSA-1834949; R-HSA-3248023 ) R-HSA-3245943 Reaction Name: Viral DNA cleavage by TREX1 See in Reactome
MONDO:0008328	TBK1	Q9UHD2	2.7.11.1	R-HSA-3270619 R-HSA-3270619 Reactome Name: IRF3-mediated induction of type I IFN See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-3134975 R-HSA-3134975 Reactome Name: Regulation of innate immune responses to cytosolic DNA See in Reactome R-HSA-9013973 R-HSA-9013973 Reactome Name: TICAM1-dependent activation of IRF3/IRF7 See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-1606341 R-HSA-1606341 Reactome Name: IRF3 mediated activation of type 1 IFN See in Reactome R-HSA-3249367 R-HSA-3249367 Reactome Name: STAT6-mediated induction of chemokines See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-1606322 R-HSA-1606322 Reactome Name: ZBP1(DAI) mediated induction of type I IFNs See in Reactome R-HSA-1834941 R-HSA-1834941 Reactome Name: STING mediated induction of host immune responses See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome	Immune System	R-HSA-1606324 ( R-HSA-1606341; R-HSA-1834949 ) R-HSA-1606324 Reaction Name: Recruitment TBK1 to dsDNA:ZBP1 followed by its activation See in Reactome R-HSA-1606327 ( R-HSA-1606341; R-HSA-1834949 ) R-HSA-1606327 Reaction Name: Phosphorylation and release of IRF3 See in Reactome R-HSA-1606345 ( R-HSA-1606341; R-HSA-1834949 ) R-HSA-1606345 Reaction Name: Recruitment of IRF3 to activated ZBP1:TBK1 See in Reactome R-HSA-166245 ( R-HSA-936964 ) R-HSA-166245 Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-1834939 ( R-HSA-1834949; R-HSA-3270619 ) R-HSA-1834939 Reaction Name: STING recruits TBK1 and IRF3 See in Reactome R-HSA-2396002 ( R-HSA-1834949; R-HSA-3270619 ) R-HSA-2396002 Reaction Name: TBK1 is phosphorylated within STING:TBK1:IRF3 complex See in Reactome R-HSA-2396007 ( R-HSA-1834949; R-HSA-3270619 ) R-HSA-2396007 Reaction Name: IRF3 is phosphorylated by TBK1 See in Reactome R-HSA-3249371 ( R-HSA-1834949; R-HSA-3249367 ) R-HSA-3249371 Reaction Name: TBK1 phosphorylates STAT6 at Ser407 See in Reactome R-HSA-3249378 ( R-HSA-1834949; R-HSA-3249367 ) R-HSA-3249378 Reaction Name: STING recruits TBK1 and STAT6 See in Reactome R-HSA-3249386 ( R-HSA-1834949; R-HSA-3134975 ) R-HSA-3249386 Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 See in Reactome R-HSA-3249390 ( R-HSA-1834949; R-HSA-3249367 ) R-HSA-3249390 Reaction Name: TBK1 is phosphorylated within STING:TBK1:STAT6 complex See in Reactome R-HSA-3249392 ( R-HSA-1834949; R-HSA-3134975 ) R-HSA-3249392 Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 See in Reactome R-HSA-8948703 ( R-HSA-1834949; R-HSA-3134975 ) R-HSA-8948703 Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 See in Reactome R-HSA-8948709 ( R-HSA-1834949; R-HSA-3134975 ) R-HSA-8948709 Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 See in Reactome R-HSA-9008684 ( R-HSA-9008059 ) R-HSA-9008684 Reaction Name: TBK1 phosphorylation See in Reactome R-HSA-9013978 ( R-HSA-9013973 ) R-HSA-9013978 Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex See in Reactome R-HSA-9013979 ( R-HSA-9013973 ) R-HSA-9013979 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 See in Reactome R-HSA-9013986 ( R-HSA-9013973 ) R-HSA-9013986 Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-936941 ( R-HSA-936964 ) R-HSA-936941 Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation See in Reactome R-HSA-937337 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937337 Reaction Name: TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination See in Reactome R-HSA-9679819 ( R-HSA-1606341; R-HSA-1834949 ) R-HSA-9679819 Reaction Name: TBK1 binds amlexanox See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-9709831 ( R-HSA-168928 ) R-HSA-9709831 Reaction Name: HSP90 binds TBK1 and IRF3 See in Reactome R-HSA-9709852 ( R-HSA-168928 ) R-HSA-9709852 Reaction Name: MAVS:TOMM70 recruits HSP90:TBK1:IRF3 See in Reactome
MONDO:0008641	TREX1	Q9NSU2	3.1.11.2	R-HSA-3270619 R-HSA-3270619 Reactome Name: IRF3-mediated induction of type I IFN See in Reactome R-HSA-3248023 R-HSA-3248023 Reactome Name: Regulation by TREX1 See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1834941 R-HSA-1834941 Reactome Name: STING mediated induction of host immune responses See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-3134975 R-HSA-3134975 Reactome Name: Regulation of innate immune responses to cytosolic DNA See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome	Immune System	R-HSA-1834939 ( R-HSA-1834949; R-HSA-3270619 ) R-HSA-1834939 Reaction Name: STING recruits TBK1 and IRF3 See in Reactome R-HSA-3244605 ( R-HSA-1834949; R-HSA-3248023 ) R-HSA-3244605 Reaction Name: TREX1 binds retroviral-derived DNA See in Reactome R-HSA-3245943 ( R-HSA-1834949; R-HSA-3248023 ) R-HSA-3245943 Reaction Name: Viral DNA cleavage by TREX1 See in Reactome
MONDO:0009165	TREX1	Q9NSU2	3.1.11.2	R-HSA-3270619 R-HSA-3270619 Reactome Name: IRF3-mediated induction of type I IFN See in Reactome R-HSA-3248023 R-HSA-3248023 Reactome Name: Regulation by TREX1 See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1834941 R-HSA-1834941 Reactome Name: STING mediated induction of host immune responses See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-3134975 R-HSA-3134975 Reactome Name: Regulation of innate immune responses to cytosolic DNA See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome	Immune System	R-HSA-1834939 ( R-HSA-1834949; R-HSA-3270619 ) R-HSA-1834939 Reaction Name: STING recruits TBK1 and IRF3 See in Reactome R-HSA-3244605 ( R-HSA-1834949; R-HSA-3248023 ) R-HSA-3244605 Reaction Name: TREX1 binds retroviral-derived DNA See in Reactome R-HSA-3245943 ( R-HSA-1834949; R-HSA-3248023 ) R-HSA-3245943 Reaction Name: Viral DNA cleavage by TREX1 See in Reactome
MONDO:0012500	TREX1	Q9NSU2	3.1.11.2	R-HSA-3270619 R-HSA-3270619 Reactome Name: IRF3-mediated induction of type I IFN See in Reactome R-HSA-3248023 R-HSA-3248023 Reactome Name: Regulation by TREX1 See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1834941 R-HSA-1834941 Reactome Name: STING mediated induction of host immune responses See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-3134975 R-HSA-3134975 Reactome Name: Regulation of innate immune responses to cytosolic DNA See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome	Immune System	R-HSA-1834939 ( R-HSA-1834949; R-HSA-3270619 ) R-HSA-1834939 Reaction Name: STING recruits TBK1 and IRF3 See in Reactome R-HSA-3244605 ( R-HSA-1834949; R-HSA-3248023 ) R-HSA-3244605 Reaction Name: TREX1 binds retroviral-derived DNA See in Reactome R-HSA-3245943 ( R-HSA-1834949; R-HSA-3248023 ) R-HSA-3245943 Reaction Name: Viral DNA cleavage by TREX1 See in Reactome
MONDO:0013118	MRE11	P49959	3.1.-.-	R-HSA-3270619 R-HSA-3270619 Reactome Name: IRF3-mediated induction of type I IFN See in Reactome R-HSA-2559586 R-HSA-2559586 Reactome Name: DNA Damage/Telomere Stress Induced Senescence See in Reactome R-HSA-5693548 R-HSA-5693548 Reactome Name: Sensing of DNA Double Strand Breaks See in Reactome R-HSA-5693554 R-HSA-5693554 Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-912446 R-HSA-912446 Reactome Name: Meiotic recombination See in Reactome R-HSA-5693568 R-HSA-5693568 Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-5693579 R-HSA-5693579 Reactome Name: Homologous DNA Pairing and Strand Exchange See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5685939 R-HSA-5685939 Reactome Name: HDR through MMEJ (alt-NHEJ) See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-5693607 R-HSA-5693607 Reactome Name: Processing of DNA double-strand break ends See in Reactome R-HSA-5693616 R-HSA-5693616 Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome R-HSA-5693571 R-HSA-5693571 Reactome Name: Nonhomologous End-Joining (NHEJ) See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-1474165 R-HSA-1474165 Reactome Name: Reproduction See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1834941 R-HSA-1834941 Reactome Name: STING mediated induction of host immune responses See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-1500620 R-HSA-1500620 Reactome Name: Meiosis See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-5693537 R-HSA-5693537 Reactome Name: Resolution of D-Loop Structures See in Reactome	Immune System Cell Cycle Gene expression (Transcription) Reproduction Cellular responses to stimuli DNA Repair	R-HSA-1834939 ( R-HSA-1834949; R-HSA-3270619 ) R-HSA-1834939 Reaction Name: STING recruits TBK1 and IRF3 See in Reactome R-HSA-3204303 ( R-HSA-1834949 ) R-HSA-3204303 Reaction Name: MRE11 binds cytosolic DNA See in Reactome R-HSA-3785768 ( R-HSA-2559586; R-HSA-5693548 ) R-HSA-3785768 Reaction Name: MRN complex binds DNA double strand breaks See in Reactome R-HSA-5682018 ( R-HSA-2559586 ) R-HSA-5682018 Reaction Name: MRN complex bound to shortened telomeres recruits ATM See in Reactome R-HSA-5682020 ( R-HSA-2559586 ) R-HSA-5682020 Reaction Name: MRN complex binds shortened telomeres See in Reactome R-HSA-5682026 ( R-HSA-2559586 ) R-HSA-5682026 Reaction Name: MRN bound to shortened telomeres activates ATM See in Reactome R-HSA-5682044 ( R-HSA-2559586; R-HSA-5693548 ) R-HSA-5682044 Reaction Name: KAT5 acetylates ATM at DNA DSBs See in Reactome R-HSA-5682586 ( R-HSA-5693565 ) R-HSA-5682586 Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs See in Reactome R-HSA-5682588 ( R-HSA-5693565 ) R-HSA-5682588 Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs See in Reactome R-HSA-5682598 ( R-HSA-5693565 ) R-HSA-5682598 Reaction Name: ATM phosphorylates HERC2 See in Reactome R-HSA-5682607 ( R-HSA-5693565 ) R-HSA-5682607 Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs See in Reactome R-HSA-5682629 ( R-HSA-5693565 ) R-HSA-5682629 Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 See in Reactome R-HSA-5682858 ( R-HSA-5693565 ) R-HSA-5682858 Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX See in Reactome R-HSA-5682863 ( R-HSA-5693565 ) R-HSA-5682863 Reaction Name: RNF168 binds DNA DSBs See in Reactome R-HSA-5682965 ( R-HSA-5693565 ) R-HSA-5682965 Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs See in Reactome R-HSA-5682967 ( R-HSA-5693565 ) R-HSA-5682967 Reaction Name: WHSC1 binds DNA DSBs See in Reactome R-HSA-5682983 ( R-HSA-5693565 ) R-HSA-5682983 Reaction Name: ATM phosphorylates WHSC1 See in Reactome R-HSA-5682992 ( R-HSA-5693565 ) R-HSA-5682992 Reaction Name: KDM4A,B bind H4K20Me2 See in Reactome R-HSA-5683077 ( R-HSA-5693565 ) R-HSA-5683077 Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B See in Reactome R-HSA-5683384 ( R-HSA-5693565 ) R-HSA-5683384 Reaction Name: UIMC1 and FAM175A bind DNA DSBs See in Reactome R-HSA-5683385 ( R-HSA-5693565 ) R-HSA-5683385 Reaction Name: Formation of BRCA1-A complex at DNA DSBs See in Reactome R-HSA-5683405 ( R-HSA-5693565 ) R-HSA-5683405 Reaction Name: PPP5C dephosphorylates TP53BP1 See in Reactome R-HSA-5683425 ( R-HSA-5693565 ) R-HSA-5683425 Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs See in Reactome R-HSA-5683735 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683735 Reaction Name: CHEK2 is recruited to DNA DSBs See in Reactome R-HSA-5683801 ( R-HSA-5693565 ) R-HSA-5683801 Reaction Name: CHEK2 phosphorylates BRCA1 See in Reactome R-HSA-5683964 ( R-HSA-5693565 ) R-HSA-5683964 Reaction Name: ATM phosphorylates EYA1-4 See in Reactome R-HSA-5683967 ( R-HSA-5693565 ) R-HSA-5683967 Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX See in Reactome R-HSA-5683986 ( R-HSA-5693565 ) R-HSA-5683986 Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX See in Reactome R-HSA-5684052 ( R-HSA-5693607 ) R-HSA-5684052 Reaction Name: PIAS4 SUMOylates MDC1 See in Reactome R-HSA-5684071 ( R-HSA-5693607 ) R-HSA-5684071 Reaction Name: RNF4 ubiquitinates MDC1 See in Reactome R-HSA-5684081 ( R-HSA-5693607 ) R-HSA-5684081 Reaction Name: MRN complex binds CDK2 and RBBP8 See in Reactome R-HSA-5684096 ( R-HSA-5693607 ) R-HSA-5684096 Reaction Name: CDK2 phosphorylates RBBP8 See in Reactome R-HSA-5684108 ( R-HSA-5693607 ) R-HSA-5684108 Reaction Name: BRCA1 binds phosphorylated RBBP8 See in Reactome R-HSA-5684140 ( R-HSA-5693607 ) R-HSA-5684140 Reaction Name: ATM phosphorylates RBBP8 See in Reactome R-HSA-5684875 ( R-HSA-5693607 ) R-HSA-5684875 Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs See in Reactome R-HSA-5684882 ( R-HSA-5693607 ) R-HSA-5684882 Reaction Name: CHEK1 is recruited to resected DNA DSBs See in Reactome R-HSA-5684887 ( R-HSA-5693607 ) R-HSA-5684887 Reaction Name: Activation of CHEK1 at resected DNA DSBs See in Reactome R-HSA-5685011 ( R-HSA-5693607 ) R-HSA-5685011 Reaction Name: ATR activation at DNA DSBs See in Reactome R-HSA-5685156 ( R-HSA-5693607 ) R-HSA-5685156 Reaction Name: ATR phosphorylates RPA2 See in Reactome R-HSA-5685341 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5685341 Reaction Name: BCDX2 complex stabilizes RAD51 filament See in Reactome R-HSA-5685838 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5685838 Reaction Name: CX3 complex binds D-loop structures See in Reactome R-HSA-5685985 ( R-HSA-5693607 ) R-HSA-5685985 Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment See in Reactome R-HSA-5685994 ( R-HSA-5693607 ) R-HSA-5685994 Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2 See in Reactome R-HSA-5686410 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686410 Reaction Name: BLM mediates dissolution of double Holliday junction See in Reactome R-HSA-5686440 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686440 Reaction Name: MUS81:EME1,EME2 cleaves D-loop See in Reactome R-HSA-5686469 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686469 Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 See in Reactome R-HSA-5686483 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686483 Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5686642 ( R-HSA-5685938 ) R-HSA-5686642 Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5686685 ( R-HSA-5693571 ) R-HSA-5686685 Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs See in Reactome R-HSA-5686704 ( R-HSA-5693571 ) R-HSA-5686704 Reaction Name: Activated ATM phosphorylates DCLRE1C See in Reactome R-HSA-5686900 ( R-HSA-5693571 ) R-HSA-5686900 Reaction Name: TP53BP1 recruits DCLRE1C to ATM See in Reactome R-HSA-5687464 ( R-HSA-5685939 ) R-HSA-5687464 Reaction Name: MRN and RBBP8 resect DNA DSBs in MMEJ See in Reactome R-HSA-5687465 ( R-HSA-5685939 ) R-HSA-5687465 Reaction Name: MRN complex binds RBBP8 See in Reactome R-HSA-5687484 ( R-HSA-5685939 ) R-HSA-5687484 Reaction Name: PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site See in Reactome R-HSA-5687640 ( R-HSA-5685939 ) R-HSA-5687640 Reaction Name: POLQ extends annealed 3'-ssDNA overhangs in MMEJ See in Reactome R-HSA-5687653 ( R-HSA-5685939 ) R-HSA-5687653 Reaction Name: PARP1,PARP2 dimers bound to MMEJ sites autoPARylate See in Reactome R-HSA-5687664 ( R-HSA-5685939 ) R-HSA-5687664 Reaction Name: FEN1 cleaves displaced ssDNA flaps during MMEJ See in Reactome R-HSA-5687673 ( R-HSA-5685939 ) R-HSA-5687673 Reaction Name: MRN recruits LIG3:XRCC1 to MMEJ sites See in Reactome R-HSA-5687675 ( R-HSA-5685939 ) R-HSA-5687675 Reaction Name: LIG3 ligates remaining SSBs in MMEJ See in Reactome R-HSA-5693536 ( R-HSA-5693565 ) R-HSA-5693536 Reaction Name: ATM phosphorylates MDC1 See in Reactome R-HSA-5693539 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693539 Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis See in Reactome R-HSA-5693540 ( R-HSA-2559586; R-HSA-5693548 ) R-HSA-5693540 Reaction Name: MRN activates ATM See in Reactome R-HSA-5693542 ( R-HSA-5693607 ) R-HSA-5693542 Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs See in Reactome R-HSA-5693549 ( R-HSA-5693565 ) R-HSA-5693549 Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs See in Reactome R-HSA-5693551 ( R-HSA-5693565 ) R-HSA-5693551 Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM See in Reactome R-HSA-5693561 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5693561 Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs See in Reactome R-HSA-5693564 ( R-HSA-5685938 ) R-HSA-5693564 Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends See in Reactome R-HSA-5693566 ( R-HSA-5693565 ) R-HSA-5693566 Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs See in Reactome R-HSA-5693580 ( R-HSA-5685938 ) R-HSA-5693580 Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs See in Reactome R-HSA-5693583 ( R-HSA-5693565 ) R-HSA-5693583 Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci See in Reactome R-HSA-5693584 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693584 Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5693589 ( R-HSA-5685942; R-HSA-5693554 ) R-HSA-5693589 Reaction Name: D-loop dissociation and strand annealing See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-5693598 ( R-HSA-5693565 ) R-HSA-5693598 Reaction Name: ATM phosphorylates NBN See in Reactome R-HSA-5693599 ( R-HSA-5693571 ) R-HSA-5693599 Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break See in Reactome R-HSA-5693602 ( R-HSA-5693565 ) R-HSA-5693602 Reaction Name: ATM recognizes H2AFX-Nucleosomes See in Reactome R-HSA-5693608 ( R-HSA-5693607 ) R-HSA-5693608 Reaction Name: Initial resection of double-strand break ends See in Reactome R-HSA-5693612 ( R-HSA-2559586; R-HSA-5693548 ) R-HSA-5693612 Reaction Name: MRN complex bound to DNA ends recruits ATM See in Reactome R-HSA-5693620 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5693620 Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51 See in Reactome R-HSA-6792712 ( R-HSA-2559586 ) R-HSA-6792712 Reaction Name: KAT5 acetylates ATM at shortened telomeres See in Reactome R-HSA-6799332 ( R-HSA-6804756; R-HSA-69473 ) R-HSA-6799332 Reaction Name: ATR phosphorylates TP53 See in Reactome R-HSA-69891 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-69891 Reaction Name: Phosphorylation and activation of CHEK2 by ATM See in Reactome R-HSA-75172 ( R-HSA-5693548 ) R-HSA-75172 Reaction Name: Formation of RAD50:MRE11 complex See in Reactome R-HSA-75174 ( R-HSA-5693548 ) R-HSA-75174 Reaction Name: Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction See in Reactome R-HSA-9023941 ( R-HSA-912446 ) R-HSA-9023941 Reaction Name: MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11 See in Reactome R-HSA-9023943 ( R-HSA-912446 ) R-HSA-9023943 Reaction Name: MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end See in Reactome
MONDO:0014423	PRKDC	P78527	2.7.11.1	R-HSA-3270619 R-HSA-3270619 Reactome Name: IRF3-mediated induction of type I IFN See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-8866654 R-HSA-8866654 Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins See in Reactome R-HSA-5693571 R-HSA-5693571 Reactome Name: Nonhomologous End-Joining (NHEJ) See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-1834941 R-HSA-1834941 Reactome Name: STING mediated induction of host immune responses See in Reactome	Immune System Metabolism of proteins DNA Repair	R-HSA-1834939 ( R-HSA-1834949; R-HSA-3270619 ) R-HSA-1834939 Reaction Name: STING recruits TBK1 and IRF3 See in Reactome R-HSA-3134821 ( R-HSA-1834949 ) R-HSA-3134821 Reaction Name: DNA-PK binds microbial dsDNA See in Reactome R-HSA-5686924 ( R-HSA-5693571 ) R-HSA-5686924 Reaction Name: DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs See in Reactome R-HSA-5687183 ( R-HSA-5693571 ) R-HSA-5687183 Reaction Name: PRKDC phosphorylates DCLRE1C at DNA DSBs See in Reactome R-HSA-5687360 ( R-HSA-5693571 ) R-HSA-5687360 Reaction Name: POLL or POLM extends aligned DNA DSB ends to fill gaps See in Reactome R-HSA-5693533 ( R-HSA-5693571 ) R-HSA-5693533 Reaction Name: DCLRE1C (ARTEMIS) processes DNA DSB ends See in Reactome R-HSA-5693574 ( R-HSA-5693571 ) R-HSA-5693574 Reaction Name: XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ See in Reactome R-HSA-5693575 ( R-HSA-5693571 ) R-HSA-5693575 Reaction Name: DNA-PKcs autophosphorylates See in Reactome R-HSA-5693578 ( R-HSA-5693571 ) R-HSA-5693578 Reaction Name: TDP1 and TDP2 process unligatable DSB ends See in Reactome R-HSA-5693604 ( R-HSA-5693571 ) R-HSA-5693604 Reaction Name: XRCC4:LIG4 ligates DNA DSB ends during NHEJ See in Reactome R-HSA-5693615 ( R-HSA-5693571 ) R-HSA-5693615 Reaction Name: Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis See in Reactome R-HSA-8938770 ( R-HSA-8866654 ) R-HSA-8938770 Reaction Name: RNF144A binds PRKDC and Ubiquitin:UBE2L3 See in Reactome R-HSA-8938773 ( R-HSA-8866654 ) R-HSA-8938773 Reaction Name: RNF144A polyubiquitinates PRKDC See in Reactome
MONDO:0014641	TBK1	Q9UHD2	2.7.11.1	R-HSA-3270619 R-HSA-3270619 Reactome Name: IRF3-mediated induction of type I IFN See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-3134975 R-HSA-3134975 Reactome Name: Regulation of innate immune responses to cytosolic DNA See in Reactome R-HSA-9013973 R-HSA-9013973 Reactome Name: TICAM1-dependent activation of IRF3/IRF7 See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-1606341 R-HSA-1606341 Reactome Name: IRF3 mediated activation of type 1 IFN See in Reactome R-HSA-3249367 R-HSA-3249367 Reactome Name: STAT6-mediated induction of chemokines See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-1606322 R-HSA-1606322 Reactome Name: ZBP1(DAI) mediated induction of type I IFNs See in Reactome R-HSA-1834941 R-HSA-1834941 Reactome Name: STING mediated induction of host immune responses See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome	Immune System	R-HSA-1606324 ( R-HSA-1606341; R-HSA-1834949 ) R-HSA-1606324 Reaction Name: Recruitment TBK1 to dsDNA:ZBP1 followed by its activation See in Reactome R-HSA-1606327 ( R-HSA-1606341; R-HSA-1834949 ) R-HSA-1606327 Reaction Name: Phosphorylation and release of IRF3 See in Reactome R-HSA-1606345 ( R-HSA-1606341; R-HSA-1834949 ) R-HSA-1606345 Reaction Name: Recruitment of IRF3 to activated ZBP1:TBK1 See in Reactome R-HSA-166245 ( R-HSA-936964 ) R-HSA-166245 Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-1834939 ( R-HSA-1834949; R-HSA-3270619 ) R-HSA-1834939 Reaction Name: STING recruits TBK1 and IRF3 See in Reactome R-HSA-2396002 ( R-HSA-1834949; R-HSA-3270619 ) R-HSA-2396002 Reaction Name: TBK1 is phosphorylated within STING:TBK1:IRF3 complex See in Reactome R-HSA-2396007 ( R-HSA-1834949; R-HSA-3270619 ) R-HSA-2396007 Reaction Name: IRF3 is phosphorylated by TBK1 See in Reactome R-HSA-3249371 ( R-HSA-1834949; R-HSA-3249367 ) R-HSA-3249371 Reaction Name: TBK1 phosphorylates STAT6 at Ser407 See in Reactome R-HSA-3249378 ( R-HSA-1834949; R-HSA-3249367 ) R-HSA-3249378 Reaction Name: STING recruits TBK1 and STAT6 See in Reactome R-HSA-3249386 ( R-HSA-1834949; R-HSA-3134975 ) R-HSA-3249386 Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 See in Reactome R-HSA-3249390 ( R-HSA-1834949; R-HSA-3249367 ) R-HSA-3249390 Reaction Name: TBK1 is phosphorylated within STING:TBK1:STAT6 complex See in Reactome R-HSA-3249392 ( R-HSA-1834949; R-HSA-3134975 ) R-HSA-3249392 Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 See in Reactome R-HSA-8948703 ( R-HSA-1834949; R-HSA-3134975 ) R-HSA-8948703 Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 See in Reactome R-HSA-8948709 ( R-HSA-1834949; R-HSA-3134975 ) R-HSA-8948709 Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 See in Reactome R-HSA-9008684 ( R-HSA-9008059 ) R-HSA-9008684 Reaction Name: TBK1 phosphorylation See in Reactome R-HSA-9013978 ( R-HSA-9013973 ) R-HSA-9013978 Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex See in Reactome R-HSA-9013979 ( R-HSA-9013973 ) R-HSA-9013979 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 See in Reactome R-HSA-9013986 ( R-HSA-9013973 ) R-HSA-9013986 Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-936941 ( R-HSA-936964 ) R-HSA-936941 Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation See in Reactome R-HSA-937337 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937337 Reaction Name: TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination See in Reactome R-HSA-9679819 ( R-HSA-1606341; R-HSA-1834949 ) R-HSA-9679819 Reaction Name: TBK1 binds amlexanox See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-9709831 ( R-HSA-168928 ) R-HSA-9709831 Reaction Name: HSP90 binds TBK1 and IRF3 See in Reactome R-HSA-9709852 ( R-HSA-168928 ) R-HSA-9709852 Reaction Name: MAVS:TOMM70 recruits HSP90:TBK1:IRF3 See in Reactome
MONDO:0014809	DDX41	Q9UJV9	3.6.4.13	R-HSA-3270619 R-HSA-3270619 Reactome Name: IRF3-mediated induction of type I IFN See in Reactome R-HSA-1834941 R-HSA-1834941 Reactome Name: STING mediated induction of host immune responses See in Reactome R-HSA-3134975 R-HSA-3134975 Reactome Name: Regulation of innate immune responses to cytosolic DNA See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome	Immune System	R-HSA-1834939 ( R-HSA-1834941; R-HSA-1834949; R-HSA-3270619 ) R-HSA-1834939 Reaction Name: STING recruits TBK1 and IRF3 See in Reactome R-HSA-3134822 ( R-HSA-1834941; R-HSA-1834949 ) R-HSA-3134822 Reaction Name: DDX41 binds viral dsDNA See in Reactome R-HSA-3134946 ( R-HSA-1834949; R-HSA-3134975 ) R-HSA-3134946 Reaction Name: DDX41 ubiquitination by TRIM21 See in Reactome R-HSA-9013869 ( R-HSA-1834941; R-HSA-1834949 ) R-HSA-9013869 Reaction Name: DDX41 binds bacterial c-di-AMP, c-di-GMP See in Reactome
MONDO:0015356	MRE11	P49959	3.1.-.-	R-HSA-3270619 R-HSA-3270619 Reactome Name: IRF3-mediated induction of type I IFN See in Reactome R-HSA-2559586 R-HSA-2559586 Reactome Name: DNA Damage/Telomere Stress Induced Senescence See in Reactome R-HSA-5693548 R-HSA-5693548 Reactome Name: Sensing of DNA Double Strand Breaks See in Reactome R-HSA-5693554 R-HSA-5693554 Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-912446 R-HSA-912446 Reactome Name: Meiotic recombination See in Reactome R-HSA-5693568 R-HSA-5693568 Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-5693579 R-HSA-5693579 Reactome Name: Homologous DNA Pairing and Strand Exchange See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5685939 R-HSA-5685939 Reactome Name: HDR through MMEJ (alt-NHEJ) See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-5693607 R-HSA-5693607 Reactome Name: Processing of DNA double-strand break ends See in Reactome R-HSA-5693616 R-HSA-5693616 Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome R-HSA-5693571 R-HSA-5693571 Reactome Name: Nonhomologous End-Joining (NHEJ) See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-1474165 R-HSA-1474165 Reactome Name: Reproduction See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1834941 R-HSA-1834941 Reactome Name: STING mediated induction of host immune responses See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-1500620 R-HSA-1500620 Reactome Name: Meiosis See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-5693537 R-HSA-5693537 Reactome Name: Resolution of D-Loop Structures See in Reactome	Immune System Cell Cycle Gene expression (Transcription) Reproduction Cellular responses to stimuli DNA Repair	R-HSA-1834939 ( R-HSA-1834949; R-HSA-3270619 ) R-HSA-1834939 Reaction Name: STING recruits TBK1 and IRF3 See in Reactome R-HSA-3204303 ( R-HSA-1834949 ) R-HSA-3204303 Reaction Name: MRE11 binds cytosolic DNA See in Reactome R-HSA-3785768 ( R-HSA-2559586; R-HSA-5693548 ) R-HSA-3785768 Reaction Name: MRN complex binds DNA double strand breaks See in Reactome R-HSA-5682018 ( R-HSA-2559586 ) R-HSA-5682018 Reaction Name: MRN complex bound to shortened telomeres recruits ATM See in Reactome R-HSA-5682020 ( R-HSA-2559586 ) R-HSA-5682020 Reaction Name: MRN complex binds shortened telomeres See in Reactome R-HSA-5682026 ( R-HSA-2559586 ) R-HSA-5682026 Reaction Name: MRN bound to shortened telomeres activates ATM See in Reactome R-HSA-5682044 ( R-HSA-2559586; R-HSA-5693548 ) R-HSA-5682044 Reaction Name: KAT5 acetylates ATM at DNA DSBs See in Reactome R-HSA-5682586 ( R-HSA-5693565 ) R-HSA-5682586 Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs See in Reactome R-HSA-5682588 ( R-HSA-5693565 ) R-HSA-5682588 Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs See in Reactome R-HSA-5682598 ( R-HSA-5693565 ) R-HSA-5682598 Reaction Name: ATM phosphorylates HERC2 See in Reactome R-HSA-5682607 ( R-HSA-5693565 ) R-HSA-5682607 Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs See in Reactome R-HSA-5682629 ( R-HSA-5693565 ) R-HSA-5682629 Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 See in Reactome R-HSA-5682858 ( R-HSA-5693565 ) R-HSA-5682858 Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX See in Reactome R-HSA-5682863 ( R-HSA-5693565 ) R-HSA-5682863 Reaction Name: RNF168 binds DNA DSBs See in Reactome R-HSA-5682965 ( R-HSA-5693565 ) R-HSA-5682965 Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs See in Reactome R-HSA-5682967 ( R-HSA-5693565 ) R-HSA-5682967 Reaction Name: WHSC1 binds DNA DSBs See in Reactome R-HSA-5682983 ( R-HSA-5693565 ) R-HSA-5682983 Reaction Name: ATM phosphorylates WHSC1 See in Reactome R-HSA-5682992 ( R-HSA-5693565 ) R-HSA-5682992 Reaction Name: KDM4A,B bind H4K20Me2 See in Reactome R-HSA-5683077 ( R-HSA-5693565 ) R-HSA-5683077 Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B See in Reactome R-HSA-5683384 ( R-HSA-5693565 ) R-HSA-5683384 Reaction Name: UIMC1 and FAM175A bind DNA DSBs See in Reactome R-HSA-5683385 ( R-HSA-5693565 ) R-HSA-5683385 Reaction Name: Formation of BRCA1-A complex at DNA DSBs See in Reactome R-HSA-5683405 ( R-HSA-5693565 ) R-HSA-5683405 Reaction Name: PPP5C dephosphorylates TP53BP1 See in Reactome R-HSA-5683425 ( R-HSA-5693565 ) R-HSA-5683425 Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs See in Reactome R-HSA-5683735 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683735 Reaction Name: CHEK2 is recruited to DNA DSBs See in Reactome R-HSA-5683801 ( R-HSA-5693565 ) R-HSA-5683801 Reaction Name: CHEK2 phosphorylates BRCA1 See in Reactome R-HSA-5683964 ( R-HSA-5693565 ) R-HSA-5683964 Reaction Name: ATM phosphorylates EYA1-4 See in Reactome R-HSA-5683967 ( R-HSA-5693565 ) R-HSA-5683967 Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX See in Reactome R-HSA-5683986 ( R-HSA-5693565 ) R-HSA-5683986 Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX See in Reactome R-HSA-5684052 ( R-HSA-5693607 ) R-HSA-5684052 Reaction Name: PIAS4 SUMOylates MDC1 See in Reactome R-HSA-5684071 ( R-HSA-5693607 ) R-HSA-5684071 Reaction Name: RNF4 ubiquitinates MDC1 See in Reactome R-HSA-5684081 ( R-HSA-5693607 ) R-HSA-5684081 Reaction Name: MRN complex binds CDK2 and RBBP8 See in Reactome R-HSA-5684096 ( R-HSA-5693607 ) R-HSA-5684096 Reaction Name: CDK2 phosphorylates RBBP8 See in Reactome R-HSA-5684108 ( R-HSA-5693607 ) R-HSA-5684108 Reaction Name: BRCA1 binds phosphorylated RBBP8 See in Reactome R-HSA-5684140 ( R-HSA-5693607 ) R-HSA-5684140 Reaction Name: ATM phosphorylates RBBP8 See in Reactome R-HSA-5684875 ( R-HSA-5693607 ) R-HSA-5684875 Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs See in Reactome R-HSA-5684882 ( R-HSA-5693607 ) R-HSA-5684882 Reaction Name: CHEK1 is recruited to resected DNA DSBs See in Reactome R-HSA-5684887 ( R-HSA-5693607 ) R-HSA-5684887 Reaction Name: Activation of CHEK1 at resected DNA DSBs See in Reactome R-HSA-5685011 ( R-HSA-5693607 ) R-HSA-5685011 Reaction Name: ATR activation at DNA DSBs See in Reactome R-HSA-5685156 ( R-HSA-5693607 ) R-HSA-5685156 Reaction Name: ATR phosphorylates RPA2 See in Reactome R-HSA-5685341 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5685341 Reaction Name: BCDX2 complex stabilizes RAD51 filament See in Reactome R-HSA-5685838 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5685838 Reaction Name: CX3 complex binds D-loop structures See in Reactome R-HSA-5685985 ( R-HSA-5693607 ) R-HSA-5685985 Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment See in Reactome R-HSA-5685994 ( R-HSA-5693607 ) R-HSA-5685994 Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2 See in Reactome R-HSA-5686410 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686410 Reaction Name: BLM mediates dissolution of double Holliday junction See in Reactome R-HSA-5686440 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686440 Reaction Name: MUS81:EME1,EME2 cleaves D-loop See in Reactome R-HSA-5686469 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686469 Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 See in Reactome R-HSA-5686483 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686483 Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5686642 ( R-HSA-5685938 ) R-HSA-5686642 Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5686685 ( R-HSA-5693571 ) R-HSA-5686685 Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs See in Reactome R-HSA-5686704 ( R-HSA-5693571 ) R-HSA-5686704 Reaction Name: Activated ATM phosphorylates DCLRE1C See in Reactome R-HSA-5686900 ( R-HSA-5693571 ) R-HSA-5686900 Reaction Name: TP53BP1 recruits DCLRE1C to ATM See in Reactome R-HSA-5687464 ( R-HSA-5685939 ) R-HSA-5687464 Reaction Name: MRN and RBBP8 resect DNA DSBs in MMEJ See in Reactome R-HSA-5687465 ( R-HSA-5685939 ) R-HSA-5687465 Reaction Name: MRN complex binds RBBP8 See in Reactome R-HSA-5687484 ( R-HSA-5685939 ) R-HSA-5687484 Reaction Name: PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site See in Reactome R-HSA-5687640 ( R-HSA-5685939 ) R-HSA-5687640 Reaction Name: POLQ extends annealed 3'-ssDNA overhangs in MMEJ See in Reactome R-HSA-5687653 ( R-HSA-5685939 ) R-HSA-5687653 Reaction Name: PARP1,PARP2 dimers bound to MMEJ sites autoPARylate See in Reactome R-HSA-5687664 ( R-HSA-5685939 ) R-HSA-5687664 Reaction Name: FEN1 cleaves displaced ssDNA flaps during MMEJ See in Reactome R-HSA-5687673 ( R-HSA-5685939 ) R-HSA-5687673 Reaction Name: MRN recruits LIG3:XRCC1 to MMEJ sites See in Reactome R-HSA-5687675 ( R-HSA-5685939 ) R-HSA-5687675 Reaction Name: LIG3 ligates remaining SSBs in MMEJ See in Reactome R-HSA-5693536 ( R-HSA-5693565 ) R-HSA-5693536 Reaction Name: ATM phosphorylates MDC1 See in Reactome R-HSA-5693539 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693539 Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis See in Reactome R-HSA-5693540 ( R-HSA-2559586; R-HSA-5693548 ) R-HSA-5693540 Reaction Name: MRN activates ATM See in Reactome R-HSA-5693542 ( R-HSA-5693607 ) R-HSA-5693542 Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs See in Reactome R-HSA-5693549 ( R-HSA-5693565 ) R-HSA-5693549 Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs See in Reactome R-HSA-5693551 ( R-HSA-5693565 ) R-HSA-5693551 Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM See in Reactome R-HSA-5693561 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5693561 Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs See in Reactome R-HSA-5693564 ( R-HSA-5685938 ) R-HSA-5693564 Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends See in Reactome R-HSA-5693566 ( R-HSA-5693565 ) R-HSA-5693566 Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs See in Reactome R-HSA-5693580 ( R-HSA-5685938 ) R-HSA-5693580 Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs See in Reactome R-HSA-5693583 ( R-HSA-5693565 ) R-HSA-5693583 Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci See in Reactome R-HSA-5693584 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693584 Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5693589 ( R-HSA-5685942; R-HSA-5693554 ) R-HSA-5693589 Reaction Name: D-loop dissociation and strand annealing See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-5693598 ( R-HSA-5693565 ) R-HSA-5693598 Reaction Name: ATM phosphorylates NBN See in Reactome R-HSA-5693599 ( R-HSA-5693571 ) R-HSA-5693599 Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break See in Reactome R-HSA-5693602 ( R-HSA-5693565 ) R-HSA-5693602 Reaction Name: ATM recognizes H2AFX-Nucleosomes See in Reactome R-HSA-5693608 ( R-HSA-5693607 ) R-HSA-5693608 Reaction Name: Initial resection of double-strand break ends See in Reactome R-HSA-5693612 ( R-HSA-2559586; R-HSA-5693548 ) R-HSA-5693612 Reaction Name: MRN complex bound to DNA ends recruits ATM See in Reactome R-HSA-5693620 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5693620 Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51 See in Reactome R-HSA-6792712 ( R-HSA-2559586 ) R-HSA-6792712 Reaction Name: KAT5 acetylates ATM at shortened telomeres See in Reactome R-HSA-6799332 ( R-HSA-6804756; R-HSA-69473 ) R-HSA-6799332 Reaction Name: ATR phosphorylates TP53 See in Reactome R-HSA-69891 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-69891 Reaction Name: Phosphorylation and activation of CHEK2 by ATM See in Reactome R-HSA-75172 ( R-HSA-5693548 ) R-HSA-75172 Reaction Name: Formation of RAD50:MRE11 complex See in Reactome R-HSA-75174 ( R-HSA-5693548 ) R-HSA-75174 Reaction Name: Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction See in Reactome R-HSA-9023941 ( R-HSA-912446 ) R-HSA-9023941 Reaction Name: MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11 See in Reactome R-HSA-9023943 ( R-HSA-912446 ) R-HSA-9023943 Reaction Name: MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end See in Reactome
MONDO:0024557	MRE11	P49959	3.1.-.-	R-HSA-3270619 R-HSA-3270619 Reactome Name: IRF3-mediated induction of type I IFN See in Reactome R-HSA-2559586 R-HSA-2559586 Reactome Name: DNA Damage/Telomere Stress Induced Senescence See in Reactome R-HSA-5693548 R-HSA-5693548 Reactome Name: Sensing of DNA Double Strand Breaks See in Reactome R-HSA-5693554 R-HSA-5693554 Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-912446 R-HSA-912446 Reactome Name: Meiotic recombination See in Reactome R-HSA-5693568 R-HSA-5693568 Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-5693579 R-HSA-5693579 Reactome Name: Homologous DNA Pairing and Strand Exchange See in Reactome R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5685939 R-HSA-5685939 Reactome Name: HDR through MMEJ (alt-NHEJ) See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-5693607 R-HSA-5693607 Reactome Name: Processing of DNA double-strand break ends See in Reactome R-HSA-5693616 R-HSA-5693616 Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome R-HSA-5693571 R-HSA-5693571 Reactome Name: Nonhomologous End-Joining (NHEJ) See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-1474165 R-HSA-1474165 Reactome Name: Reproduction See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1834941 R-HSA-1834941 Reactome Name: STING mediated induction of host immune responses See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-1500620 R-HSA-1500620 Reactome Name: Meiosis See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-5693537 R-HSA-5693537 Reactome Name: Resolution of D-Loop Structures See in Reactome	Immune System Cell Cycle Gene expression (Transcription) Reproduction Cellular responses to stimuli DNA Repair	R-HSA-1834939 ( R-HSA-1834949; R-HSA-3270619 ) R-HSA-1834939 Reaction Name: STING recruits TBK1 and IRF3 See in Reactome R-HSA-3204303 ( R-HSA-1834949 ) R-HSA-3204303 Reaction Name: MRE11 binds cytosolic DNA See in Reactome R-HSA-3785768 ( R-HSA-2559586; R-HSA-5693548 ) R-HSA-3785768 Reaction Name: MRN complex binds DNA double strand breaks See in Reactome R-HSA-5682018 ( R-HSA-2559586 ) R-HSA-5682018 Reaction Name: MRN complex bound to shortened telomeres recruits ATM See in Reactome R-HSA-5682020 ( R-HSA-2559586 ) R-HSA-5682020 Reaction Name: MRN complex binds shortened telomeres See in Reactome R-HSA-5682026 ( R-HSA-2559586 ) R-HSA-5682026 Reaction Name: MRN bound to shortened telomeres activates ATM See in Reactome R-HSA-5682044 ( R-HSA-2559586; R-HSA-5693548 ) R-HSA-5682044 Reaction Name: KAT5 acetylates ATM at DNA DSBs See in Reactome R-HSA-5682586 ( R-HSA-5693565 ) R-HSA-5682586 Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs See in Reactome R-HSA-5682588 ( R-HSA-5693565 ) R-HSA-5682588 Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs See in Reactome R-HSA-5682598 ( R-HSA-5693565 ) R-HSA-5682598 Reaction Name: ATM phosphorylates HERC2 See in Reactome R-HSA-5682607 ( R-HSA-5693565 ) R-HSA-5682607 Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs See in Reactome R-HSA-5682629 ( R-HSA-5693565 ) R-HSA-5682629 Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 See in Reactome R-HSA-5682858 ( R-HSA-5693565 ) R-HSA-5682858 Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX See in Reactome R-HSA-5682863 ( R-HSA-5693565 ) R-HSA-5682863 Reaction Name: RNF168 binds DNA DSBs See in Reactome R-HSA-5682965 ( R-HSA-5693565 ) R-HSA-5682965 Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs See in Reactome R-HSA-5682967 ( R-HSA-5693565 ) R-HSA-5682967 Reaction Name: WHSC1 binds DNA DSBs See in Reactome R-HSA-5682983 ( R-HSA-5693565 ) R-HSA-5682983 Reaction Name: ATM phosphorylates WHSC1 See in Reactome R-HSA-5682992 ( R-HSA-5693565 ) R-HSA-5682992 Reaction Name: KDM4A,B bind H4K20Me2 See in Reactome R-HSA-5683077 ( R-HSA-5693565 ) R-HSA-5683077 Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B See in Reactome R-HSA-5683384 ( R-HSA-5693565 ) R-HSA-5683384 Reaction Name: UIMC1 and FAM175A bind DNA DSBs See in Reactome R-HSA-5683385 ( R-HSA-5693565 ) R-HSA-5683385 Reaction Name: Formation of BRCA1-A complex at DNA DSBs See in Reactome R-HSA-5683405 ( R-HSA-5693565 ) R-HSA-5683405 Reaction Name: PPP5C dephosphorylates TP53BP1 See in Reactome R-HSA-5683425 ( R-HSA-5693565 ) R-HSA-5683425 Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs See in Reactome R-HSA-5683735 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683735 Reaction Name: CHEK2 is recruited to DNA DSBs See in Reactome R-HSA-5683801 ( R-HSA-5693565 ) R-HSA-5683801 Reaction Name: CHEK2 phosphorylates BRCA1 See in Reactome R-HSA-5683964 ( R-HSA-5693565 ) R-HSA-5683964 Reaction Name: ATM phosphorylates EYA1-4 See in Reactome R-HSA-5683967 ( R-HSA-5693565 ) R-HSA-5683967 Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX See in Reactome R-HSA-5683986 ( R-HSA-5693565 ) R-HSA-5683986 Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX See in Reactome R-HSA-5684052 ( R-HSA-5693607 ) R-HSA-5684052 Reaction Name: PIAS4 SUMOylates MDC1 See in Reactome R-HSA-5684071 ( R-HSA-5693607 ) R-HSA-5684071 Reaction Name: RNF4 ubiquitinates MDC1 See in Reactome R-HSA-5684081 ( R-HSA-5693607 ) R-HSA-5684081 Reaction Name: MRN complex binds CDK2 and RBBP8 See in Reactome R-HSA-5684096 ( R-HSA-5693607 ) R-HSA-5684096 Reaction Name: CDK2 phosphorylates RBBP8 See in Reactome R-HSA-5684108 ( R-HSA-5693607 ) R-HSA-5684108 Reaction Name: BRCA1 binds phosphorylated RBBP8 See in Reactome R-HSA-5684140 ( R-HSA-5693607 ) R-HSA-5684140 Reaction Name: ATM phosphorylates RBBP8 See in Reactome R-HSA-5684875 ( R-HSA-5693607 ) R-HSA-5684875 Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs See in Reactome R-HSA-5684882 ( R-HSA-5693607 ) R-HSA-5684882 Reaction Name: CHEK1 is recruited to resected DNA DSBs See in Reactome R-HSA-5684887 ( R-HSA-5693607 ) R-HSA-5684887 Reaction Name: Activation of CHEK1 at resected DNA DSBs See in Reactome R-HSA-5685011 ( R-HSA-5693607 ) R-HSA-5685011 Reaction Name: ATR activation at DNA DSBs See in Reactome R-HSA-5685156 ( R-HSA-5693607 ) R-HSA-5685156 Reaction Name: ATR phosphorylates RPA2 See in Reactome R-HSA-5685341 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5685341 Reaction Name: BCDX2 complex stabilizes RAD51 filament See in Reactome R-HSA-5685838 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5685838 Reaction Name: CX3 complex binds D-loop structures See in Reactome R-HSA-5685985 ( R-HSA-5693607 ) R-HSA-5685985 Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment See in Reactome R-HSA-5685994 ( R-HSA-5693607 ) R-HSA-5685994 Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2 See in Reactome R-HSA-5686410 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686410 Reaction Name: BLM mediates dissolution of double Holliday junction See in Reactome R-HSA-5686440 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686440 Reaction Name: MUS81:EME1,EME2 cleaves D-loop See in Reactome R-HSA-5686469 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686469 Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 See in Reactome R-HSA-5686483 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686483 Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5686642 ( R-HSA-5685938 ) R-HSA-5686642 Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5686685 ( R-HSA-5693571 ) R-HSA-5686685 Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs See in Reactome R-HSA-5686704 ( R-HSA-5693571 ) R-HSA-5686704 Reaction Name: Activated ATM phosphorylates DCLRE1C See in Reactome R-HSA-5686900 ( R-HSA-5693571 ) R-HSA-5686900 Reaction Name: TP53BP1 recruits DCLRE1C to ATM See in Reactome R-HSA-5687464 ( R-HSA-5685939 ) R-HSA-5687464 Reaction Name: MRN and RBBP8 resect DNA DSBs in MMEJ See in Reactome R-HSA-5687465 ( R-HSA-5685939 ) R-HSA-5687465 Reaction Name: MRN complex binds RBBP8 See in Reactome R-HSA-5687484 ( R-HSA-5685939 ) R-HSA-5687484 Reaction Name: PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site See in Reactome R-HSA-5687640 ( R-HSA-5685939 ) R-HSA-5687640 Reaction Name: POLQ extends annealed 3'-ssDNA overhangs in MMEJ See in Reactome R-HSA-5687653 ( R-HSA-5685939 ) R-HSA-5687653 Reaction Name: PARP1,PARP2 dimers bound to MMEJ sites autoPARylate See in Reactome R-HSA-5687664 ( R-HSA-5685939 ) R-HSA-5687664 Reaction Name: FEN1 cleaves displaced ssDNA flaps during MMEJ See in Reactome R-HSA-5687673 ( R-HSA-5685939 ) R-HSA-5687673 Reaction Name: MRN recruits LIG3:XRCC1 to MMEJ sites See in Reactome R-HSA-5687675 ( R-HSA-5685939 ) R-HSA-5687675 Reaction Name: LIG3 ligates remaining SSBs in MMEJ See in Reactome R-HSA-5693536 ( R-HSA-5693565 ) R-HSA-5693536 Reaction Name: ATM phosphorylates MDC1 See in Reactome R-HSA-5693539 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693539 Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis See in Reactome R-HSA-5693540 ( R-HSA-2559586; R-HSA-5693548 ) R-HSA-5693540 Reaction Name: MRN activates ATM See in Reactome R-HSA-5693542 ( R-HSA-5693607 ) R-HSA-5693542 Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs See in Reactome R-HSA-5693549 ( R-HSA-5693565 ) R-HSA-5693549 Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs See in Reactome R-HSA-5693551 ( R-HSA-5693565 ) R-HSA-5693551 Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM See in Reactome R-HSA-5693561 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5693561 Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs See in Reactome R-HSA-5693564 ( R-HSA-5685938 ) R-HSA-5693564 Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends See in Reactome R-HSA-5693566 ( R-HSA-5693565 ) R-HSA-5693566 Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs See in Reactome R-HSA-5693580 ( R-HSA-5685938 ) R-HSA-5693580 Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs See in Reactome R-HSA-5693583 ( R-HSA-5693565 ) R-HSA-5693583 Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci See in Reactome R-HSA-5693584 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693584 Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5693589 ( R-HSA-5685942; R-HSA-5693554 ) R-HSA-5693589 Reaction Name: D-loop dissociation and strand annealing See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-5693598 ( R-HSA-5693565 ) R-HSA-5693598 Reaction Name: ATM phosphorylates NBN See in Reactome R-HSA-5693599 ( R-HSA-5693571 ) R-HSA-5693599 Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break See in Reactome R-HSA-5693602 ( R-HSA-5693565 ) R-HSA-5693602 Reaction Name: ATM recognizes H2AFX-Nucleosomes See in Reactome R-HSA-5693608 ( R-HSA-5693607 ) R-HSA-5693608 Reaction Name: Initial resection of double-strand break ends See in Reactome R-HSA-5693612 ( R-HSA-2559586; R-HSA-5693548 ) R-HSA-5693612 Reaction Name: MRN complex bound to DNA ends recruits ATM See in Reactome R-HSA-5693620 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5693620 Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51 See in Reactome R-HSA-6792712 ( R-HSA-2559586 ) R-HSA-6792712 Reaction Name: KAT5 acetylates ATM at shortened telomeres See in Reactome R-HSA-6799332 ( R-HSA-6804756; R-HSA-69473 ) R-HSA-6799332 Reaction Name: ATR phosphorylates TP53 See in Reactome R-HSA-69891 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-69891 Reaction Name: Phosphorylation and activation of CHEK2 by ATM See in Reactome R-HSA-75172 ( R-HSA-5693548 ) R-HSA-75172 Reaction Name: Formation of RAD50:MRE11 complex See in Reactome R-HSA-75174 ( R-HSA-5693548 ) R-HSA-75174 Reaction Name: Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction See in Reactome R-HSA-9023941 ( R-HSA-912446 ) R-HSA-9023941 Reaction Name: MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11 See in Reactome R-HSA-9023943 ( R-HSA-912446 ) R-HSA-9023943 Reaction Name: MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end See in Reactome
MONDO:0054754	TBK1	Q9UHD2	2.7.11.1	R-HSA-3270619 R-HSA-3270619 Reactome Name: IRF3-mediated induction of type I IFN See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-3134975 R-HSA-3134975 Reactome Name: Regulation of innate immune responses to cytosolic DNA See in Reactome R-HSA-9013973 R-HSA-9013973 Reactome Name: TICAM1-dependent activation of IRF3/IRF7 See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-1606341 R-HSA-1606341 Reactome Name: IRF3 mediated activation of type 1 IFN See in Reactome R-HSA-3249367 R-HSA-3249367 Reactome Name: STAT6-mediated induction of chemokines See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-1606322 R-HSA-1606322 Reactome Name: ZBP1(DAI) mediated induction of type I IFNs See in Reactome R-HSA-1834941 R-HSA-1834941 Reactome Name: STING mediated induction of host immune responses See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome	Immune System	R-HSA-1606324 ( R-HSA-1606341; R-HSA-1834949 ) R-HSA-1606324 Reaction Name: Recruitment TBK1 to dsDNA:ZBP1 followed by its activation See in Reactome R-HSA-1606327 ( R-HSA-1606341; R-HSA-1834949 ) R-HSA-1606327 Reaction Name: Phosphorylation and release of IRF3 See in Reactome R-HSA-1606345 ( R-HSA-1606341; R-HSA-1834949 ) R-HSA-1606345 Reaction Name: Recruitment of IRF3 to activated ZBP1:TBK1 See in Reactome R-HSA-166245 ( R-HSA-936964 ) R-HSA-166245 Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-1834939 ( R-HSA-1834949; R-HSA-3270619 ) R-HSA-1834939 Reaction Name: STING recruits TBK1 and IRF3 See in Reactome R-HSA-2396002 ( R-HSA-1834949; R-HSA-3270619 ) R-HSA-2396002 Reaction Name: TBK1 is phosphorylated within STING:TBK1:IRF3 complex See in Reactome R-HSA-2396007 ( R-HSA-1834949; R-HSA-3270619 ) R-HSA-2396007 Reaction Name: IRF3 is phosphorylated by TBK1 See in Reactome R-HSA-3249371 ( R-HSA-1834949; R-HSA-3249367 ) R-HSA-3249371 Reaction Name: TBK1 phosphorylates STAT6 at Ser407 See in Reactome R-HSA-3249378 ( R-HSA-1834949; R-HSA-3249367 ) R-HSA-3249378 Reaction Name: STING recruits TBK1 and STAT6 See in Reactome R-HSA-3249386 ( R-HSA-1834949; R-HSA-3134975 ) R-HSA-3249386 Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 See in Reactome R-HSA-3249390 ( R-HSA-1834949; R-HSA-3249367 ) R-HSA-3249390 Reaction Name: TBK1 is phosphorylated within STING:TBK1:STAT6 complex See in Reactome R-HSA-3249392 ( R-HSA-1834949; R-HSA-3134975 ) R-HSA-3249392 Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 See in Reactome R-HSA-8948703 ( R-HSA-1834949; R-HSA-3134975 ) R-HSA-8948703 Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 See in Reactome R-HSA-8948709 ( R-HSA-1834949; R-HSA-3134975 ) R-HSA-8948709 Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 See in Reactome R-HSA-9008684 ( R-HSA-9008059 ) R-HSA-9008684 Reaction Name: TBK1 phosphorylation See in Reactome R-HSA-9013978 ( R-HSA-9013973 ) R-HSA-9013978 Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex See in Reactome R-HSA-9013979 ( R-HSA-9013973 ) R-HSA-9013979 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 See in Reactome R-HSA-9013986 ( R-HSA-9013973 ) R-HSA-9013986 Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-936941 ( R-HSA-936964 ) R-HSA-936941 Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation See in Reactome R-HSA-937337 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937337 Reaction Name: TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination See in Reactome R-HSA-9679819 ( R-HSA-1606341; R-HSA-1834949 ) R-HSA-9679819 Reaction Name: TBK1 binds amlexanox See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-9709831 ( R-HSA-168928 ) R-HSA-9709831 Reaction Name: HSP90 binds TBK1 and IRF3 See in Reactome R-HSA-9709852 ( R-HSA-168928 ) R-HSA-9709852 Reaction Name: MAVS:TOMM70 recruits HSP90:TBK1:IRF3 See in Reactome