DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-3232142)

Number of enzymes:	3
Number of disease:	3
Number of reactomes:	38
Number of reactions:	108

Search results (Reactome ID: R-HSA-3232142)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0011953	RANBP2	P49792	2.3.2.-	R-HSA-2467813 R-HSA-2467813 Reactome Name: Separation of Sister Chromatids See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome R-HSA-1169408 R-HSA-1169408 Reactome Name: ISG15 antiviral mechanism See in Reactome R-HSA-4615885 R-HSA-4615885 Reactome Name: SUMOylation of DNA replication proteins See in Reactome R-HSA-2500257 R-HSA-2500257 Reactome Name: Resolution of Sister Chromatid Cohesion See in Reactome R-HSA-159230 R-HSA-159230 Reactome Name: Transport of the SLBP Dependant Mature mRNA See in Reactome R-HSA-159231 R-HSA-159231 Reactome Name: Transport of Mature mRNA Derived from an Intronless Transcript See in Reactome R-HSA-9648025 R-HSA-9648025 Reactome Name: EML4 and NUDC in mitotic spindle formation See in Reactome R-HSA-3232142 R-HSA-3232142 Reactome Name: SUMOylation of ubiquitinylation proteins See in Reactome R-HSA-4085377 R-HSA-4085377 Reactome Name: SUMOylation of SUMOylation proteins See in Reactome R-HSA-159236 R-HSA-159236 Reactome Name: Transport of Mature mRNA derived from an Intron-Containing Transcript See in Reactome R-HSA-4551638 R-HSA-4551638 Reactome Name: SUMOylation of chromatin organization proteins See in Reactome R-HSA-141444 R-HSA-141444 Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-191859 R-HSA-191859 Reactome Name: snRNP Assembly See in Reactome R-HSA-159227 R-HSA-159227 Reactome Name: Transport of the SLBP independent Mature mRNA See in Reactome R-HSA-6784531 R-HSA-6784531 Reactome Name: tRNA processing in the nucleus See in Reactome R-HSA-4570464 R-HSA-4570464 Reactome Name: SUMOylation of RNA binding proteins See in Reactome R-HSA-3108214 R-HSA-3108214 Reactome Name: SUMOylation of DNA damage response and repair proteins See in Reactome R-HSA-5578749 R-HSA-5578749 Reactome Name: Transcriptional regulation by small RNAs See in Reactome R-HSA-3371453 R-HSA-3371453 Reactome Name: Regulation of HSF1-mediated heat shock response See in Reactome R-HSA-68877 R-HSA-68877 Reactome Name: Mitotic Prometaphase See in Reactome R-HSA-3301854 R-HSA-3301854 Reactome Name: Nuclear Pore Complex (NPC) Disassembly See in Reactome	R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-72203 R-HSA-72203 Reactome Name: Processing of Capped Intron-Containing Pre-mRNA See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-72306 R-HSA-72306 Reactome Name: tRNA processing See in Reactome R-HSA-194441 R-HSA-194441 Reactome Name: Metabolism of non-coding RNA See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-159234 R-HSA-159234 Reactome Name: Transport of Mature mRNAs Derived from Intronless Transcripts See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-211000 R-HSA-211000 Reactome Name: Gene Silencing by RNA See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-141424 R-HSA-141424 Reactome Name: Amplification of signal from the kinetochores See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome R-HSA-1169410 R-HSA-1169410 Reactome Name: Antiviral mechanism by IFN-stimulated genes See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-2980766 R-HSA-2980766 Reactome Name: Nuclear Envelope Breakdown See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-72202 R-HSA-72202 Reactome Name: Transport of Mature Transcript to Cytoplasm See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-69618 R-HSA-69618 Reactome Name: Mitotic Spindle Checkpoint See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-68875 R-HSA-68875 Reactome Name: Mitotic Prophase See in Reactome	Immune System Metabolism Cell Cycle Gene expression (Transcription) Cellular responses to stimuli Metabolism of RNA Metabolism of proteins Signal Transduction	R-HSA-111439 ( R-HSA-159227 ) R-HSA-111439 Reaction Name: Docking of Mature Histone mRNA complex:TAP at the NPC See in Reactome R-HSA-1176059 ( R-HSA-1169408 ) R-HSA-1176059 Reaction Name: Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus See in Reactome R-HSA-141409 ( R-HSA-141444 ) R-HSA-141409 Reaction Name: Mad1 binds kinetochore See in Reactome R-HSA-141422 ( R-HSA-141444 ) R-HSA-141422 Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1 See in Reactome R-HSA-141431 ( R-HSA-141444 ) R-HSA-141431 Reaction Name: MAD2 associates with the Mad1 kinetochore complex See in Reactome R-HSA-141439 ( R-HSA-141444 ) R-HSA-141439 Reaction Name: Release of activated MAD2 from kinetochores See in Reactome R-HSA-158441 ( R-HSA-159231 ) R-HSA-158441 Reaction Name: Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC See in Reactome R-HSA-158447 ( R-HSA-159231 ) R-HSA-158447 Reaction Name: Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC See in Reactome R-HSA-158481 ( R-HSA-159227 ) R-HSA-158481 Reaction Name: Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC See in Reactome R-HSA-158484 ( R-HSA-159227 ) R-HSA-158484 Reaction Name: Release of the SLBP independent Histone mRNA from the NPC See in Reactome R-HSA-159046 ( R-HSA-159230 ) R-HSA-159046 Reaction Name: Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC See in Reactome R-HSA-159050 ( R-HSA-159230 ) R-HSA-159050 Reaction Name: Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex See in Reactome R-HSA-1638803 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-1638803 Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres See in Reactome R-HSA-1638821 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-1638821 Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin See in Reactome R-HSA-170796 ( R-HSA-170822 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-191825 ( R-HSA-191859 ) R-HSA-191825 Reaction Name: Nuclear export of snRNA transcripts See in Reactome R-HSA-191830 ( R-HSA-191859 ) R-HSA-191830 Reaction Name: snRNP nuclear import and release See in Reactome R-HSA-2467809 ( R-HSA-2467813 ) R-HSA-2467809 Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin See in Reactome R-HSA-2467811 ( R-HSA-2467813 ) R-HSA-2467811 Reaction Name: Separation of sister chromatids See in Reactome R-HSA-2468287 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-2468287 Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres See in Reactome R-HSA-2484822 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-2484822 Reaction Name: Kinetochore assembly See in Reactome R-HSA-2990880 ( R-HSA-3301854 ) R-HSA-2990880 Reaction Name: NEK6/NEK7 phosphorylates NUP98 See in Reactome R-HSA-2990882 ( R-HSA-3301854 ) R-HSA-2990882 Reaction Name: CDK1 phosphorylates NUP98 See in Reactome R-HSA-3000348 ( R-HSA-3108214 ) R-HSA-3000348 Reaction Name: RANBP2 SUMOylates SP100 with SUMO2 See in Reactome R-HSA-3000399 ( R-HSA-3108214 ) R-HSA-3000399 Reaction Name: RANBP2 SUMOylates SP100 with SUMO1 See in Reactome R-HSA-3000411 ( R-HSA-3108214 ) R-HSA-3000411 Reaction Name: RANBP2 SUMOylates PML with SUMO2 See in Reactome R-HSA-375302 ( R-HSA-68877 ) R-HSA-375302 Reaction Name: Kinetochore capture of astral microtubules See in Reactome R-HSA-4551649 ( R-HSA-4085377 ) R-HSA-4551649 Reaction Name: RANBP2 SUMOylates RANBP2 with SUMO1 See in Reactome R-HSA-4551679 ( R-HSA-4085377 ) R-HSA-4551679 Reaction Name: RANBP2 SUMOylates RANBP2 with SUMO2 See in Reactome R-HSA-4570493 ( R-HSA-4570464 ) R-HSA-4570493 Reaction Name: RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 See in Reactome R-HSA-4615872 ( R-HSA-4551638 ) R-HSA-4615872 Reaction Name: RANBP2 SUMOylates HDAC4 with SUMO1 See in Reactome R-HSA-4615987 ( R-HSA-4551638 ) R-HSA-4615987 Reaction Name: RANBP2 SUMOylates HDAC4 with SUMO2,3 See in Reactome R-HSA-4655355 ( R-HSA-4615885 ) R-HSA-4655355 Reaction Name: RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) See in Reactome R-HSA-5228508 ( R-HSA-3108214 ) R-HSA-5228508 Reaction Name: RANBP2 SUMOylates PML with SUMO1 See in Reactome R-HSA-5228523 ( R-HSA-3232142 ) R-HSA-5228523 Reaction Name: RANBP2 SUMOylates MDM2 with SUMO1 See in Reactome R-HSA-5228525 ( R-HSA-4615885 ) R-HSA-5228525 Reaction Name: RANBP2 SUMOylates TOP2A with SUMO1 See in Reactome R-HSA-5252041 ( R-HSA-3371453 ) R-HSA-5252041 Reaction Name: NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm See in Reactome R-HSA-5578744 ( R-HSA-5578749 ) R-HSA-5578744 Reaction Name: Importin-8 imports AGO2:miRNA into the nucleus See in Reactome R-HSA-5666129 ( R-HSA-5663220 ) R-HSA-5666129 Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores See in Reactome R-HSA-5666160 ( R-HSA-5663220 ) R-HSA-5666160 Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores See in Reactome R-HSA-5666169 ( R-HSA-5663220 ) R-HSA-5666169 Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 See in Reactome R-HSA-6783483 ( R-HSA-6784531 ) R-HSA-6783483 Reaction Name: tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol See in Reactome R-HSA-75096 ( R-HSA-159236 ) R-HSA-75096 Reaction Name: Docking of the TAP:EJC Complex with the NPC See in Reactome R-HSA-75097 ( R-HSA-159236 ) R-HSA-75097 Reaction Name: Transport of the export-competent mRNP complex through the NPC See in Reactome R-HSA-75098 ( R-HSA-159236 ) R-HSA-75098 Reaction Name: mRNP complex dissociates from cytosolic face of NPC See in Reactome R-HSA-77587 ( R-HSA-159230 ) R-HSA-77587 Reaction Name: Docking of Mature Replication Dependent Histone mRNA with the NPC See in Reactome R-HSA-77594 ( R-HSA-159231 ) R-HSA-77594 Reaction Name: Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC See in Reactome R-HSA-9648114 ( R-HSA-68877; R-HSA-9648025 ) R-HSA-9648114 Reaction Name: EML4 recruits NUDC to mitotic spindle See in Reactome
MONDO:0019005	PIAS1	O75925	2.3.2.-	R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-3232118 R-HSA-3232118 Reactome Name: SUMOylation of transcription factors See in Reactome R-HSA-3232142 R-HSA-3232142 Reactome Name: SUMOylation of ubiquitinylation proteins See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-4551638 R-HSA-4551638 Reactome Name: SUMOylation of chromatin organization proteins See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-3108214 R-HSA-3108214 Reactome Name: SUMOylation of DNA damage response and repair proteins See in Reactome R-HSA-4090294 R-HSA-4090294 Reactome Name: SUMOylation of intracellular receptors See in Reactome	R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome	Immune System Metabolism of proteins DNA Repair	R-HSA-2997616 ( R-HSA-3108214 ) R-HSA-2997616 Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO2,3 See in Reactome R-HSA-2997709 ( R-HSA-3108214 ) R-HSA-2997709 Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO1 See in Reactome R-HSA-3000434 ( R-HSA-3232142 ) R-HSA-3000434 Reaction Name: PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 See in Reactome R-HSA-3247493 ( R-HSA-3232118 ) R-HSA-3247493 Reaction Name: PIAS1 SUMOylates SP3 with SUMO1 See in Reactome R-HSA-3465545 ( R-HSA-3232118 ) R-HSA-3465545 Reaction Name: PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 See in Reactome R-HSA-3900194 ( R-HSA-3899300 ) R-HSA-3900194 Reaction Name: PIAS1 SUMOylates DDX5 with SUMO2 See in Reactome R-HSA-3968414 ( R-HSA-3232118 ) R-HSA-3968414 Reaction Name: UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 See in Reactome R-HSA-4085347 ( R-HSA-3899300 ) R-HSA-4085347 Reaction Name: PIAS1 SUMOylates SAFB with SUMO1 See in Reactome R-HSA-4085372 ( R-HSA-3899300 ) R-HSA-4085372 Reaction Name: PIAS1 SUMOylates SAFB with SUMO2,3 See in Reactome R-HSA-4086036 ( R-HSA-3899300 ) R-HSA-4086036 Reaction Name: PIAS1,3 SUMOylate NRIP1 with SUMO1 See in Reactome R-HSA-4090281 ( R-HSA-3232118 ) R-HSA-4090281 Reaction Name: PIAS1,2-1 SUMOylate HIC1 with SUMO1 See in Reactome R-HSA-4090288 ( R-HSA-3899300 ) R-HSA-4090288 Reaction Name: PIAS1,3 SUMOylate MBD1 with SUMO1 See in Reactome R-HSA-4090390 ( R-HSA-4090294 ) R-HSA-4090390 Reaction Name: PIAS1,2-1 SUMOylates AR with SUMO1 See in Reactome R-HSA-4090408 ( R-HSA-4090294 ) R-HSA-4090408 Reaction Name: PIAS1,3 SUMOylate ESR1 with SUMO1 See in Reactome R-HSA-4341016 ( R-HSA-4090294 ) R-HSA-4341016 Reaction Name: PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 See in Reactome R-HSA-4546385 ( R-HSA-4090294 ) R-HSA-4546385 Reaction Name: PIAS1,3 SUMOylates NR5A1 with SUMO2 See in Reactome R-HSA-4546386 ( R-HSA-4090294 ) R-HSA-4546386 Reaction Name: PIAS1,3 SUMOylates NR5A1 with SUMO1 See in Reactome R-HSA-4568848 ( R-HSA-3108214 ) R-HSA-4568848 Reaction Name: PIAS1,2-1 SUMOylates XRCC4 with SUMO1 See in Reactome R-HSA-4615839 ( R-HSA-4551638 ) R-HSA-4615839 Reaction Name: PIAS1 SUMOylates SATB1 with SUMO2,3 See in Reactome R-HSA-4615900 ( R-HSA-4551638 ) R-HSA-4615900 Reaction Name: PIAS1 SUMOylates SATB2 with SUMO3 See in Reactome R-HSA-4615905 ( R-HSA-4551638 ) R-HSA-4615905 Reaction Name: PIAS1 SUMOylates SATB1 with SUMO1 See in Reactome R-HSA-4717461 ( R-HSA-4090294 ) R-HSA-4717461 Reaction Name: PIAS1,2-2 SUMOylate PPARG with SUMO1 See in Reactome R-HSA-4717521 ( R-HSA-4090294 ) R-HSA-4717521 Reaction Name: PIAS1 SUMOylates NR2C1 (TR2) See in Reactome R-HSA-4719424 ( R-HSA-4090294 ) R-HSA-4719424 Reaction Name: PIAS1 SUMOylates THRB with SUMO1. See in Reactome R-HSA-4719448 ( R-HSA-4090294 ) R-HSA-4719448 Reaction Name: PIAS1 SUMOylates THRB with SUMO3 See in Reactome R-HSA-4755494 ( R-HSA-4090294 ) R-HSA-4755494 Reaction Name: PIAS1,2-1 SUMOylate NR5A2 with SUMO1 See in Reactome R-HSA-5228521 ( R-HSA-3899300 ) R-HSA-5228521 Reaction Name: PIAS1,4 SUMOylate CASP8AP2 with SUMO1 See in Reactome R-HSA-6790454 ( R-HSA-5696395 ) R-HSA-6790454 Reaction Name: SUMOylation of XPC See in Reactome R-HSA-6804468 ( R-HSA-3232118 ) R-HSA-6804468 Reaction Name: PIAS1 SUMOylates SP3 with SUMO2 See in Reactome R-HSA-6804485 ( R-HSA-4551638 ) R-HSA-6804485 Reaction Name: PIAS1 SUMOylates L3MBTL2 with SUMO2 See in Reactome R-HSA-877281 ( R-HSA-877312 ) R-HSA-877281 Reaction Name: PIAS1 binds p-STAT1 dimer See in Reactome
MONDO:0032868	MDM2	Q00987	2.3.2.27	R-HSA-2559585 R-HSA-2559585 Reactome Name: Oncogene Induced Senescence See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-3232118 R-HSA-3232118 Reactome Name: SUMOylation of transcription factors See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-3232142 R-HSA-3232142 Reactome Name: SUMOylation of ubiquitinylation proteins See in Reactome R-HSA-399719 R-HSA-399719 Reactome Name: Trafficking of AMPA receptors See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-69541 R-HSA-69541 Reactome Name: Stabilization of p53 See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-69563 R-HSA-69563 Reactome Name: p53-Dependent G1 DNA Damage Response See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-69580 R-HSA-69580 Reactome Name: p53-Dependent G1/S DNA damage checkpoint See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-399721 R-HSA-399721 Reactome Name: Glutamate binding, activation of AMPA receptors and synaptic plasticity See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-69615 R-HSA-69615 Reactome Name: G1/S DNA Damage Checkpoints See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Gene expression (Transcription) Neuronal System Cellular responses to stimuli Metabolism of proteins Signal Transduction	R-HSA-198599 ( R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-2997706 ( R-HSA-3232118 ) R-HSA-2997706 Reaction Name: MDM2 SUMOylates TP53 with SUMO2,3 See in Reactome R-HSA-3000434 ( R-HSA-3232142 ) R-HSA-3000434 Reaction Name: PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 See in Reactome R-HSA-3215295 ( R-HSA-6804757 ) R-HSA-3215295 Reaction Name: USP7 deubiquitinates MDM2 See in Reactome R-HSA-3222072 ( R-HSA-6804757 ) R-HSA-3222072 Reaction Name: DAXX binds Ub-MDM2 and USP7 See in Reactome R-HSA-349426 ( R-HSA-6804757; R-HSA-69541 ) R-HSA-349426 Reaction Name: Phosphorylation of MDM4 by CHEK2 See in Reactome R-HSA-349455 ( R-HSA-6804757; R-HSA-69541 ) R-HSA-349455 Reaction Name: Phosphorylation of MDM4 by ATM See in Reactome R-HSA-3700992 ( R-HSA-6804757 ) R-HSA-3700992 Reaction Name: TP53 stimulates MDM2 transcription See in Reactome R-HSA-416320 ( R-HSA-399719 ) R-HSA-416320 Reaction Name: Trafficking of GluR1-containing AMPA receptors See in Reactome R-HSA-5228523 ( R-HSA-3232142 ) R-HSA-5228523 Reaction Name: RANBP2 SUMOylates MDM2 with SUMO1 See in Reactome R-HSA-5633460 ( R-HSA-6804757; R-HSA-69541 ) R-HSA-5633460 Reaction Name: MDM2 binds TP53 See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-5689972 ( R-HSA-5689880; R-HSA-6804757 ) R-HSA-5689972 Reaction Name: USP2 deubiquitinates MDM2,MDM4 See in Reactome R-HSA-6792863 ( R-HSA-6804757 ) R-HSA-6792863 Reaction Name: PP2A-PP2R5C dephosphorylates MDM2 See in Reactome R-HSA-6792871 ( R-HSA-6804757 ) R-HSA-6792871 Reaction Name: CCNG1 recruits PP2A-PPP2R5C to MDM2 See in Reactome R-HSA-6793661 ( R-HSA-6804757 ) R-HSA-6793661 Reaction Name: (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 See in Reactome R-HSA-6793666 ( R-HSA-6804757 ) R-HSA-6793666 Reaction Name: MDM2 translocates to the nucleus See in Reactome R-HSA-6795460 ( R-HSA-6804757 ) R-HSA-6795460 Reaction Name: SGK1 phosphorylates MDM2 See in Reactome R-HSA-6795667 ( R-HSA-6804757 ) R-HSA-6795667 Reaction Name: MDM2 translocates to the cytosol See in Reactome R-HSA-6798373 ( R-HSA-6804756 ) R-HSA-6798373 Reaction Name: MDM2 ubiquitinates DYRK2 See in Reactome R-HSA-6804253 ( R-HSA-6804760 ) R-HSA-6804253 Reaction Name: MDM2 ubiquitinates JMY See in Reactome R-HSA-6804724 ( R-HSA-6804757; R-HSA-69541 ) R-HSA-6804724 Reaction Name: MDM2 ubiquitinates phosphorylated MDM4 See in Reactome R-HSA-6804741 ( R-HSA-6804757; R-HSA-69541 ) R-HSA-6804741 Reaction Name: MDM2 forms homo- or heterodimers See in Reactome R-HSA-6804879 ( R-HSA-2559580; R-HSA-2559585; R-HSA-6804757; R-HSA-69541 ) R-HSA-6804879 Reaction Name: MDM2 ubiquitinates TP53 See in Reactome R-HSA-6804942 ( R-HSA-6804757 ) R-HSA-6804942 Reaction Name: MDM2 homodimers auto-ubiquitinate See in Reactome R-HSA-6804955 ( R-HSA-6804757; R-HSA-69541 ) R-HSA-6804955 Reaction Name: ATM phosphorylates MDM2 See in Reactome R-HSA-6804996 ( R-HSA-2559580; R-HSA-2559585; R-HSA-6804757 ) R-HSA-6804996 Reaction Name: p14ARF sequesters MDM2 See in Reactome R-HSA-6804998 ( R-HSA-2559580; R-HSA-2559585; R-HSA-6804757 ) R-HSA-6804998 Reaction Name: p14ARF forms a ternary complex with MDM2 and TP53 See in Reactome R-HSA-6805022 ( R-HSA-6804757 ) R-HSA-6805022 Reaction Name: USP2 binds the heterodimer of MDM2 and MDM4 See in Reactome R-HSA-8952371 ( R-HSA-8941858 ) R-HSA-8952371 Reaction Name: MDM2 binds RUNX3 See in Reactome R-HSA-8952382 ( R-HSA-8941858 ) R-HSA-8952382 Reaction Name: MDM2 polyubiquitinates RUNX3 See in Reactome