DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-3232118)

Number of enzymes:	2
Number of disease:	2
Number of reactomes:	18
Number of reactions:	61

Search results (Reactome ID: R-HSA-3232118)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0019005	PIAS1	O75925	2.3.2.-	R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-3232118 R-HSA-3232118 Reactome Name: SUMOylation of transcription factors See in Reactome R-HSA-3232142 R-HSA-3232142 Reactome Name: SUMOylation of ubiquitinylation proteins See in Reactome R-HSA-3899300 R-HSA-3899300 Reactome Name: SUMOylation of transcription cofactors See in Reactome R-HSA-4551638 R-HSA-4551638 Reactome Name: SUMOylation of chromatin organization proteins See in Reactome R-HSA-877312 R-HSA-877312 Reactome Name: Regulation of IFNG signaling See in Reactome R-HSA-3108214 R-HSA-3108214 Reactome Name: SUMOylation of DNA damage response and repair proteins See in Reactome R-HSA-4090294 R-HSA-4090294 Reactome Name: SUMOylation of intracellular receptors See in Reactome	R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome	Immune System Metabolism of proteins DNA Repair	R-HSA-2997616 ( R-HSA-3108214 ) R-HSA-2997616 Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO2,3 See in Reactome R-HSA-2997709 ( R-HSA-3108214 ) R-HSA-2997709 Reaction Name: PIAS1,4 SUMOylates BRCA1 with SUMO1 See in Reactome R-HSA-3000434 ( R-HSA-3232142 ) R-HSA-3000434 Reaction Name: PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 See in Reactome R-HSA-3247493 ( R-HSA-3232118 ) R-HSA-3247493 Reaction Name: PIAS1 SUMOylates SP3 with SUMO1 See in Reactome R-HSA-3465545 ( R-HSA-3232118 ) R-HSA-3465545 Reaction Name: PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 See in Reactome R-HSA-3900194 ( R-HSA-3899300 ) R-HSA-3900194 Reaction Name: PIAS1 SUMOylates DDX5 with SUMO2 See in Reactome R-HSA-3968414 ( R-HSA-3232118 ) R-HSA-3968414 Reaction Name: UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 See in Reactome R-HSA-4085347 ( R-HSA-3899300 ) R-HSA-4085347 Reaction Name: PIAS1 SUMOylates SAFB with SUMO1 See in Reactome R-HSA-4085372 ( R-HSA-3899300 ) R-HSA-4085372 Reaction Name: PIAS1 SUMOylates SAFB with SUMO2,3 See in Reactome R-HSA-4086036 ( R-HSA-3899300 ) R-HSA-4086036 Reaction Name: PIAS1,3 SUMOylate NRIP1 with SUMO1 See in Reactome R-HSA-4090281 ( R-HSA-3232118 ) R-HSA-4090281 Reaction Name: PIAS1,2-1 SUMOylate HIC1 with SUMO1 See in Reactome R-HSA-4090288 ( R-HSA-3899300 ) R-HSA-4090288 Reaction Name: PIAS1,3 SUMOylate MBD1 with SUMO1 See in Reactome R-HSA-4090390 ( R-HSA-4090294 ) R-HSA-4090390 Reaction Name: PIAS1,2-1 SUMOylates AR with SUMO1 See in Reactome R-HSA-4090408 ( R-HSA-4090294 ) R-HSA-4090408 Reaction Name: PIAS1,3 SUMOylate ESR1 with SUMO1 See in Reactome R-HSA-4341016 ( R-HSA-4090294 ) R-HSA-4341016 Reaction Name: PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 See in Reactome R-HSA-4546385 ( R-HSA-4090294 ) R-HSA-4546385 Reaction Name: PIAS1,3 SUMOylates NR5A1 with SUMO2 See in Reactome R-HSA-4546386 ( R-HSA-4090294 ) R-HSA-4546386 Reaction Name: PIAS1,3 SUMOylates NR5A1 with SUMO1 See in Reactome R-HSA-4568848 ( R-HSA-3108214 ) R-HSA-4568848 Reaction Name: PIAS1,2-1 SUMOylates XRCC4 with SUMO1 See in Reactome R-HSA-4615839 ( R-HSA-4551638 ) R-HSA-4615839 Reaction Name: PIAS1 SUMOylates SATB1 with SUMO2,3 See in Reactome R-HSA-4615900 ( R-HSA-4551638 ) R-HSA-4615900 Reaction Name: PIAS1 SUMOylates SATB2 with SUMO3 See in Reactome R-HSA-4615905 ( R-HSA-4551638 ) R-HSA-4615905 Reaction Name: PIAS1 SUMOylates SATB1 with SUMO1 See in Reactome R-HSA-4717461 ( R-HSA-4090294 ) R-HSA-4717461 Reaction Name: PIAS1,2-2 SUMOylate PPARG with SUMO1 See in Reactome R-HSA-4717521 ( R-HSA-4090294 ) R-HSA-4717521 Reaction Name: PIAS1 SUMOylates NR2C1 (TR2) See in Reactome R-HSA-4719424 ( R-HSA-4090294 ) R-HSA-4719424 Reaction Name: PIAS1 SUMOylates THRB with SUMO1. See in Reactome R-HSA-4719448 ( R-HSA-4090294 ) R-HSA-4719448 Reaction Name: PIAS1 SUMOylates THRB with SUMO3 See in Reactome R-HSA-4755494 ( R-HSA-4090294 ) R-HSA-4755494 Reaction Name: PIAS1,2-1 SUMOylate NR5A2 with SUMO1 See in Reactome R-HSA-5228521 ( R-HSA-3899300 ) R-HSA-5228521 Reaction Name: PIAS1,4 SUMOylate CASP8AP2 with SUMO1 See in Reactome R-HSA-6790454 ( R-HSA-5696395 ) R-HSA-6790454 Reaction Name: SUMOylation of XPC See in Reactome R-HSA-6804468 ( R-HSA-3232118 ) R-HSA-6804468 Reaction Name: PIAS1 SUMOylates SP3 with SUMO2 See in Reactome R-HSA-6804485 ( R-HSA-4551638 ) R-HSA-6804485 Reaction Name: PIAS1 SUMOylates L3MBTL2 with SUMO2 See in Reactome R-HSA-877281 ( R-HSA-877312 ) R-HSA-877281 Reaction Name: PIAS1 binds p-STAT1 dimer See in Reactome
MONDO:0032868	MDM2	Q00987	2.3.2.27	R-HSA-2559585 R-HSA-2559585 Reactome Name: Oncogene Induced Senescence See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-3232118 R-HSA-3232118 Reactome Name: SUMOylation of transcription factors See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-3232142 R-HSA-3232142 Reactome Name: SUMOylation of ubiquitinylation proteins See in Reactome R-HSA-399719 R-HSA-399719 Reactome Name: Trafficking of AMPA receptors See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-69541 R-HSA-69541 Reactome Name: Stabilization of p53 See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-69563 R-HSA-69563 Reactome Name: p53-Dependent G1 DNA Damage Response See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-69580 R-HSA-69580 Reactome Name: p53-Dependent G1/S DNA damage checkpoint See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-399721 R-HSA-399721 Reactome Name: Glutamate binding, activation of AMPA receptors and synaptic plasticity See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-69615 R-HSA-69615 Reactome Name: G1/S DNA Damage Checkpoints See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Gene expression (Transcription) Neuronal System Cellular responses to stimuli Metabolism of proteins Signal Transduction	R-HSA-198599 ( R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-2997706 ( R-HSA-3232118 ) R-HSA-2997706 Reaction Name: MDM2 SUMOylates TP53 with SUMO2,3 See in Reactome R-HSA-3000434 ( R-HSA-3232142 ) R-HSA-3000434 Reaction Name: PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 See in Reactome R-HSA-3215295 ( R-HSA-6804757 ) R-HSA-3215295 Reaction Name: USP7 deubiquitinates MDM2 See in Reactome R-HSA-3222072 ( R-HSA-6804757 ) R-HSA-3222072 Reaction Name: DAXX binds Ub-MDM2 and USP7 See in Reactome R-HSA-349426 ( R-HSA-6804757; R-HSA-69541 ) R-HSA-349426 Reaction Name: Phosphorylation of MDM4 by CHEK2 See in Reactome R-HSA-349455 ( R-HSA-6804757; R-HSA-69541 ) R-HSA-349455 Reaction Name: Phosphorylation of MDM4 by ATM See in Reactome R-HSA-3700992 ( R-HSA-6804757 ) R-HSA-3700992 Reaction Name: TP53 stimulates MDM2 transcription See in Reactome R-HSA-416320 ( R-HSA-399719 ) R-HSA-416320 Reaction Name: Trafficking of GluR1-containing AMPA receptors See in Reactome R-HSA-5228523 ( R-HSA-3232142 ) R-HSA-5228523 Reaction Name: RANBP2 SUMOylates MDM2 with SUMO1 See in Reactome R-HSA-5633460 ( R-HSA-6804757; R-HSA-69541 ) R-HSA-5633460 Reaction Name: MDM2 binds TP53 See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-5689972 ( R-HSA-5689880; R-HSA-6804757 ) R-HSA-5689972 Reaction Name: USP2 deubiquitinates MDM2,MDM4 See in Reactome R-HSA-6792863 ( R-HSA-6804757 ) R-HSA-6792863 Reaction Name: PP2A-PP2R5C dephosphorylates MDM2 See in Reactome R-HSA-6792871 ( R-HSA-6804757 ) R-HSA-6792871 Reaction Name: CCNG1 recruits PP2A-PPP2R5C to MDM2 See in Reactome R-HSA-6793661 ( R-HSA-6804757 ) R-HSA-6793661 Reaction Name: (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 See in Reactome R-HSA-6793666 ( R-HSA-6804757 ) R-HSA-6793666 Reaction Name: MDM2 translocates to the nucleus See in Reactome R-HSA-6795460 ( R-HSA-6804757 ) R-HSA-6795460 Reaction Name: SGK1 phosphorylates MDM2 See in Reactome R-HSA-6795667 ( R-HSA-6804757 ) R-HSA-6795667 Reaction Name: MDM2 translocates to the cytosol See in Reactome R-HSA-6798373 ( R-HSA-6804756 ) R-HSA-6798373 Reaction Name: MDM2 ubiquitinates DYRK2 See in Reactome R-HSA-6804253 ( R-HSA-6804760 ) R-HSA-6804253 Reaction Name: MDM2 ubiquitinates JMY See in Reactome R-HSA-6804724 ( R-HSA-6804757; R-HSA-69541 ) R-HSA-6804724 Reaction Name: MDM2 ubiquitinates phosphorylated MDM4 See in Reactome R-HSA-6804741 ( R-HSA-6804757; R-HSA-69541 ) R-HSA-6804741 Reaction Name: MDM2 forms homo- or heterodimers See in Reactome R-HSA-6804879 ( R-HSA-2559580; R-HSA-2559585; R-HSA-6804757; R-HSA-69541 ) R-HSA-6804879 Reaction Name: MDM2 ubiquitinates TP53 See in Reactome R-HSA-6804942 ( R-HSA-6804757 ) R-HSA-6804942 Reaction Name: MDM2 homodimers auto-ubiquitinate See in Reactome R-HSA-6804955 ( R-HSA-6804757; R-HSA-69541 ) R-HSA-6804955 Reaction Name: ATM phosphorylates MDM2 See in Reactome R-HSA-6804996 ( R-HSA-2559580; R-HSA-2559585; R-HSA-6804757 ) R-HSA-6804996 Reaction Name: p14ARF sequesters MDM2 See in Reactome R-HSA-6804998 ( R-HSA-2559580; R-HSA-2559585; R-HSA-6804757 ) R-HSA-6804998 Reaction Name: p14ARF forms a ternary complex with MDM2 and TP53 See in Reactome R-HSA-6805022 ( R-HSA-6804757 ) R-HSA-6805022 Reaction Name: USP2 binds the heterodimer of MDM2 and MDM4 See in Reactome R-HSA-8952371 ( R-HSA-8941858 ) R-HSA-8952371 Reaction Name: MDM2 binds RUNX3 See in Reactome R-HSA-8952382 ( R-HSA-8941858 ) R-HSA-8952382 Reaction Name: MDM2 polyubiquitinates RUNX3 See in Reactome