DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-3214842)

Number of enzymes:	8
Number of disease:	8
Number of reactomes:	12
Number of reactions:	67

Search results (Reactome ID: R-HSA-3214842)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0010286	PHF8	Q9UPP1	1.14.11.65 1.14.11.27	R-HSA-2299718 R-HSA-2299718 Reactome Name: Condensation of Prophase Chromosomes See in Reactome R-HSA-3214842 R-HSA-3214842 Reactome Name: HDMs demethylate histones See in Reactome	R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-68875 R-HSA-68875 Reactome Name: Mitotic Prophase See in Reactome	Chromatin organization Cell Cycle	R-HSA-4724284 ( R-HSA-3214842 ) R-HSA-4724284 Reaction Name: KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 See in Reactome R-HSA-5423117 ( R-HSA-3214842 ) R-HSA-5423117 Reaction Name: PHF8 demethylates MeK21-histone H4 See in Reactome R-HSA-5661115 ( R-HSA-3214842 ) R-HSA-5661115 Reaction Name: KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 See in Reactome
MONDO:0010355	KDM5C	P41229	1.14.11.67	R-HSA-3214842 R-HSA-3214842 Reactome Name: HDMs demethylate histones See in Reactome	R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome	Chromatin organization	R-HSA-4754181 ( R-HSA-3214842 ) R-HSA-4754181 Reaction Name: KDM5A-D demethylate Me2K5-histone H3 See in Reactome R-HSA-5661116 ( R-HSA-3214842 ) R-HSA-5661116 Reaction Name: KDM5A-D demethylate Me3K5-histone H3 See in Reactome
MONDO:0010465	KDM6A	O15550	1.14.11.68	R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-3214842 R-HSA-3214842 Reactome Name: HDMs demethylate histones See in Reactome	R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome	Chromatin organization Developmental Biology	R-HSA-4754187 ( R-HSA-3214842 ) R-HSA-4754187 Reaction Name: KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-5617483 ( R-HSA-5617472 ) R-HSA-5617483 Reaction Name: HOXA2 gene is transcribed See in Reactome R-HSA-5617484 ( R-HSA-5617472 ) R-HSA-5617484 Reaction Name: EGR2 (KROX20) activates HOXA2 expression See in Reactome R-HSA-5617486 ( R-HSA-5617472 ) R-HSA-5617486 Reaction Name: HOXB2 gene is transcribed See in Reactome R-HSA-5617492 ( R-HSA-5617472 ) R-HSA-5617492 Reaction Name: EGR2 (KROX20) activates HOXB2 expression See in Reactome R-HSA-5617641 ( R-HSA-5617472 ) R-HSA-5617641 Reaction Name: MAFB (KREISLER) and HOXB1:PBX1:PKNOX1 (HOXB1:PBX1:PREP1) activate HOXA3 expression See in Reactome R-HSA-5617661 ( R-HSA-5617472 ) R-HSA-5617661 Reaction Name: MAFB:JUN and EGR2 activate HOXB3 expression See in Reactome R-HSA-5617672 ( R-HSA-5617472 ) R-HSA-5617672 Reaction Name: HOXB3 gene is transcribed See in Reactome R-HSA-5617676 ( R-HSA-5617472 ) R-HSA-5617676 Reaction Name: HOXA3 gene is transcribed See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-5617866 ( R-HSA-5617472 ) R-HSA-5617866 Reaction Name: HOXC4 gene is transcribed See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-5617887 ( R-HSA-5617472 ) R-HSA-5617887 Reaction Name: HOXC4 chromatin is activated See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-5621002 ( R-HSA-5617472 ) R-HSA-5621002 Reaction Name: HOXB1 activates HOXB2 expression See in Reactome R-HSA-5621010 ( R-HSA-5617472 ) R-HSA-5621010 Reaction Name: HOXB1 activates HOXA2 expression See in Reactome R-HSA-5661121 ( R-HSA-3214842 ) R-HSA-5661121 Reaction Name: KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-6810139 ( R-HSA-5617472 ) R-HSA-6810139 Reaction Name: HOXA2 chromatin is activated See in Reactome R-HSA-6810158 ( R-HSA-5617472 ) R-HSA-6810158 Reaction Name: HOXB3 chromatin is activated See in Reactome R-HSA-6810159 ( R-HSA-5617472 ) R-HSA-6810159 Reaction Name: HOXB2 chromatin is activated See in Reactome R-HSA-6810161 ( R-HSA-5617472 ) R-HSA-6810161 Reaction Name: HOXA3 chromatin is activated See in Reactome
MONDO:0014751	KDM1A	O60341	1.14.99.66	R-HSA-5625886 R-HSA-5625886 Reactome Name: Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-3214842 R-HSA-3214842 Reactome Name: HDMs demethylate histones See in Reactome R-HSA-3214815 R-HSA-3214815 Reactome Name: HDACs deacetylate histones See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome	R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome	Signal Transduction Chromatin organization Hemostasis	R-HSA-3214912 ( R-HSA-3214842 ) R-HSA-3214912 Reaction Name: KDM1A, KDM1B demethylate MeK5-histone H3 See in Reactome R-HSA-3769447 ( R-HSA-3214815 ) R-HSA-3769447 Reaction Name: HDAC1:2-containing complex deacetylate histones See in Reactome R-HSA-5625848 ( R-HSA-5625886 ) R-HSA-5625848 Reaction Name: KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters See in Reactome R-HSA-5625849 ( R-HSA-5625886 ) R-HSA-5625849 Reaction Name: Demethylase KDM1A binds KLK2 and KLK3 promoters See in Reactome R-HSA-5625870 ( R-HSA-5625886 ) R-HSA-5625870 Reaction Name: KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters See in Reactome R-HSA-5661123 ( R-HSA-3214842 ) R-HSA-5661123 Reaction Name: KDM1A, KDM1B demethylate Me2K5-histone H3 See in Reactome R-HSA-6807077 ( R-HSA-8943724 ) R-HSA-6807077 Reaction Name: NR2E1 associated with transcription repressors binds PTEN promoter See in Reactome R-HSA-8944104 ( R-HSA-8943724 ) R-HSA-8944104 Reaction Name: PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN See in Reactome R-HSA-9011984 ( R-HSA-9018519 ) R-HSA-9011984 Reaction Name: KDM1A is recruited to MYC and BCL2 genes See in Reactome R-HSA-9011985 ( R-HSA-9018519 ) R-HSA-9011985 Reaction Name: KDM1A demethylates H3 on MYC and BCL genes in response to estrogen See in Reactome R-HSA-9024361 ( R-HSA-9029569 ) R-HSA-9024361 Reaction Name: Expression of ABCG1 regulated by NR1H2,3 See in Reactome R-HSA-9024386 ( R-HSA-9029569 ) R-HSA-9024386 Reaction Name: Oxysterol-induced binding of NR1H2,3:RXR to the ABCG1 gene See in Reactome R-HSA-9679787 ( R-HSA-3214815 ) R-HSA-9679787 Reaction Name: HDAC1:2-containing complex binds HDAC2 Inhibitors See in Reactome R-HSA-996727 ( R-HSA-983231 ) R-HSA-996727 Reaction Name: REST recruits the BHC complex See in Reactome
MONDO:0020850	KDM5B	Q9UGL1	1.14.11.67	R-HSA-8866911 R-HSA-8866911 Reactome Name: TFAP2 (AP-2) family regulates transcription of cell cycle factors See in Reactome R-HSA-3214842 R-HSA-3214842 Reactome Name: HDMs demethylate histones See in Reactome	R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome	Gene expression (Transcription) Chromatin organization	R-HSA-4754181 ( R-HSA-3214842 ) R-HSA-4754181 Reaction Name: KDM5A-D demethylate Me2K5-histone H3 See in Reactome R-HSA-5661116 ( R-HSA-3214842 ) R-HSA-5661116 Reaction Name: KDM5A-D demethylate Me3K5-histone H3 See in Reactome R-HSA-8865256 ( R-HSA-8866911 ) R-HSA-8865256 Reaction Name: CDKN1A gene expression is stimulated by TFAP2A and repressed by TFAP2C See in Reactome R-HSA-8865265 ( R-HSA-8866911 ) R-HSA-8865265 Reaction Name: TFAP2C homodimer binds MYC and KDM5B See in Reactome R-HSA-8865280 ( R-HSA-8866911 ) R-HSA-8865280 Reaction Name: TFAP2C homodimer binds the CDKN1A (p21) gene promoter See in Reactome
MONDO:0030012	KDM3B	Q7LBC6	1.14.11.65	R-HSA-3214842 R-HSA-3214842 Reactome Name: HDMs demethylate histones See in Reactome	R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome	Chromatin organization	R-HSA-4724284 ( R-HSA-3214842 ) R-HSA-4724284 Reaction Name: KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 See in Reactome R-HSA-5661115 ( R-HSA-3214842 ) R-HSA-5661115 Reaction Name: KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 See in Reactome
MONDO:0032790	KDM6B	O15054	1.14.11.68	R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-3214842 R-HSA-3214842 Reactome Name: HDMs demethylate histones See in Reactome	R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome	Chromatin organization Cellular responses to stimuli	R-HSA-3222546 ( R-HSA-2559580 ) R-HSA-3222546 Reaction Name: AP-1 complex stimulates KDM6B transcription See in Reactome R-HSA-3222593 ( R-HSA-2559580 ) R-HSA-3222593 Reaction Name: KDM6B demethylates H3K27me3 on p16INK4A promoter See in Reactome R-HSA-3223200 ( R-HSA-2559580 ) R-HSA-3223200 Reaction Name: Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription See in Reactome R-HSA-4754187 ( R-HSA-3214842 ) R-HSA-4754187 Reaction Name: KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 See in Reactome R-HSA-5661121 ( R-HSA-3214842 ) R-HSA-5661121 Reaction Name: KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 See in Reactome R-HSA-8979071 ( R-HSA-2559580 ) R-HSA-8979071 Reaction Name: KDM6B binds iron See in Reactome
MONDO:0060596	KDM4B	O94953	1.14.11.66	R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-3214842 R-HSA-3214842 Reactome Name: HDMs demethylate histones See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome	R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome	Chromatin organization DNA Repair Signal Transduction	R-HSA-4724279 ( R-HSA-3214842 ) R-HSA-4724279 Reaction Name: KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 See in Reactome R-HSA-5661120 ( R-HSA-3214842 ) R-HSA-5661120 Reaction Name: KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 See in Reactome R-HSA-5682586 ( R-HSA-5693565 ) R-HSA-5682586 Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs See in Reactome R-HSA-5682588 ( R-HSA-5693565 ) R-HSA-5682588 Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs See in Reactome R-HSA-5682598 ( R-HSA-5693565 ) R-HSA-5682598 Reaction Name: ATM phosphorylates HERC2 See in Reactome R-HSA-5682607 ( R-HSA-5693565 ) R-HSA-5682607 Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs See in Reactome R-HSA-5682629 ( R-HSA-5693565 ) R-HSA-5682629 Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 See in Reactome R-HSA-5682858 ( R-HSA-5693565 ) R-HSA-5682858 Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX See in Reactome R-HSA-5682863 ( R-HSA-5693565 ) R-HSA-5682863 Reaction Name: RNF168 binds DNA DSBs See in Reactome R-HSA-5682992 ( R-HSA-5693565 ) R-HSA-5682992 Reaction Name: KDM4A,B bind H4K20Me2 See in Reactome R-HSA-5683077 ( R-HSA-5693565 ) R-HSA-5683077 Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B See in Reactome R-HSA-9011949 ( R-HSA-9018519 ) R-HSA-9011949 Reaction Name: KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers See in Reactome R-HSA-9011952 ( R-HSA-9018519 ) R-HSA-9011952 Reaction Name: ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers See in Reactome R-HSA-9011966 ( R-HSA-9018519 ) R-HSA-9011966 Reaction Name: Estrogen-responsive KDM4B gene expression See in Reactome