DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-3134975)

Number of enzymes:	3
Number of disease:	6
Number of reactomes:	13
Number of reactions:	43

Search results (Reactome ID: R-HSA-3134975)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0008328	TBK1	Q9UHD2	2.7.11.1	R-HSA-3270619 R-HSA-3270619 Reactome Name: IRF3-mediated induction of type I IFN See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-3134975 R-HSA-3134975 Reactome Name: Regulation of innate immune responses to cytosolic DNA See in Reactome R-HSA-9013973 R-HSA-9013973 Reactome Name: TICAM1-dependent activation of IRF3/IRF7 See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-1606341 R-HSA-1606341 Reactome Name: IRF3 mediated activation of type 1 IFN See in Reactome R-HSA-3249367 R-HSA-3249367 Reactome Name: STAT6-mediated induction of chemokines See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-1606322 R-HSA-1606322 Reactome Name: ZBP1(DAI) mediated induction of type I IFNs See in Reactome R-HSA-1834941 R-HSA-1834941 Reactome Name: STING mediated induction of host immune responses See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome	Immune System	R-HSA-1606324 ( R-HSA-1606341 ) R-HSA-1606324 Reaction Name: Recruitment TBK1 to dsDNA:ZBP1 followed by its activation See in Reactome R-HSA-1606327 ( R-HSA-1606341 ) R-HSA-1606327 Reaction Name: Phosphorylation and release of IRF3 See in Reactome R-HSA-1606345 ( R-HSA-1606341 ) R-HSA-1606345 Reaction Name: Recruitment of IRF3 to activated ZBP1:TBK1 See in Reactome R-HSA-166245 ( R-HSA-936964 ) R-HSA-166245 Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-1834939 ( R-HSA-1834941; R-HSA-3270619 ) R-HSA-1834939 Reaction Name: STING recruits TBK1 and IRF3 See in Reactome R-HSA-2396002 ( R-HSA-1834941; R-HSA-3270619 ) R-HSA-2396002 Reaction Name: TBK1 is phosphorylated within STING:TBK1:IRF3 complex See in Reactome R-HSA-2396007 ( R-HSA-1834941; R-HSA-3270619 ) R-HSA-2396007 Reaction Name: IRF3 is phosphorylated by TBK1 See in Reactome R-HSA-3249371 ( R-HSA-1834941; R-HSA-3249367 ) R-HSA-3249371 Reaction Name: TBK1 phosphorylates STAT6 at Ser407 See in Reactome R-HSA-3249378 ( R-HSA-1834941; R-HSA-3249367 ) R-HSA-3249378 Reaction Name: STING recruits TBK1 and STAT6 See in Reactome R-HSA-3249386 ( R-HSA-3134975 ) R-HSA-3249386 Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 See in Reactome R-HSA-3249390 ( R-HSA-1834941; R-HSA-3249367 ) R-HSA-3249390 Reaction Name: TBK1 is phosphorylated within STING:TBK1:STAT6 complex See in Reactome R-HSA-3249392 ( R-HSA-3134975 ) R-HSA-3249392 Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 See in Reactome R-HSA-8948703 ( R-HSA-3134975 ) R-HSA-8948703 Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 See in Reactome R-HSA-8948709 ( R-HSA-3134975 ) R-HSA-8948709 Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 See in Reactome R-HSA-9008684 ( R-HSA-9008059 ) R-HSA-9008684 Reaction Name: TBK1 phosphorylation See in Reactome R-HSA-9013978 ( R-HSA-9013973 ) R-HSA-9013978 Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex See in Reactome R-HSA-9013979 ( R-HSA-9013973 ) R-HSA-9013979 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 See in Reactome R-HSA-9013986 ( R-HSA-9013973 ) R-HSA-9013986 Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-936941 ( R-HSA-936964 ) R-HSA-936941 Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation See in Reactome R-HSA-937337 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937337 Reaction Name: TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination See in Reactome R-HSA-9679819 ( R-HSA-1606341 ) R-HSA-9679819 Reaction Name: TBK1 binds amlexanox See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-9709831 ( R-HSA-168928 ) R-HSA-9709831 Reaction Name: HSP90 binds TBK1 and IRF3 See in Reactome R-HSA-9709852 ( R-HSA-168928 ) R-HSA-9709852 Reaction Name: MAVS:TOMM70 recruits HSP90:TBK1:IRF3 See in Reactome
MONDO:0009683	TRIM32	Q13049	2.3.2.27	R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-3134975 R-HSA-3134975 Reactome Name: Regulation of innate immune responses to cytosolic DNA See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome	Immune System	R-HSA-1964496 ( R-HSA-3134975 ) R-HSA-1964496 Reaction Name: STING binds TRIM32 or TRIM56 See in Reactome R-HSA-3134804 ( R-HSA-3134975 ) R-HSA-3134804 Reaction Name: STING ubiquitination by TRIM32 or TRIM56 See in Reactome R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome
MONDO:0014439	TRIM32	Q13049	2.3.2.27	R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-3134975 R-HSA-3134975 Reactome Name: Regulation of innate immune responses to cytosolic DNA See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome	Immune System	R-HSA-1964496 ( R-HSA-3134975 ) R-HSA-1964496 Reaction Name: STING binds TRIM32 or TRIM56 See in Reactome R-HSA-3134804 ( R-HSA-3134975 ) R-HSA-3134804 Reaction Name: STING ubiquitination by TRIM32 or TRIM56 See in Reactome R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome
MONDO:0014641	TBK1	Q9UHD2	2.7.11.1	R-HSA-3270619 R-HSA-3270619 Reactome Name: IRF3-mediated induction of type I IFN See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-3134975 R-HSA-3134975 Reactome Name: Regulation of innate immune responses to cytosolic DNA See in Reactome R-HSA-9013973 R-HSA-9013973 Reactome Name: TICAM1-dependent activation of IRF3/IRF7 See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-1606341 R-HSA-1606341 Reactome Name: IRF3 mediated activation of type 1 IFN See in Reactome R-HSA-3249367 R-HSA-3249367 Reactome Name: STAT6-mediated induction of chemokines See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-1606322 R-HSA-1606322 Reactome Name: ZBP1(DAI) mediated induction of type I IFNs See in Reactome R-HSA-1834941 R-HSA-1834941 Reactome Name: STING mediated induction of host immune responses See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome	Immune System	R-HSA-1606324 ( R-HSA-1606341 ) R-HSA-1606324 Reaction Name: Recruitment TBK1 to dsDNA:ZBP1 followed by its activation See in Reactome R-HSA-1606327 ( R-HSA-1606341 ) R-HSA-1606327 Reaction Name: Phosphorylation and release of IRF3 See in Reactome R-HSA-1606345 ( R-HSA-1606341 ) R-HSA-1606345 Reaction Name: Recruitment of IRF3 to activated ZBP1:TBK1 See in Reactome R-HSA-166245 ( R-HSA-936964 ) R-HSA-166245 Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-1834939 ( R-HSA-1834941; R-HSA-3270619 ) R-HSA-1834939 Reaction Name: STING recruits TBK1 and IRF3 See in Reactome R-HSA-2396002 ( R-HSA-1834941; R-HSA-3270619 ) R-HSA-2396002 Reaction Name: TBK1 is phosphorylated within STING:TBK1:IRF3 complex See in Reactome R-HSA-2396007 ( R-HSA-1834941; R-HSA-3270619 ) R-HSA-2396007 Reaction Name: IRF3 is phosphorylated by TBK1 See in Reactome R-HSA-3249371 ( R-HSA-1834941; R-HSA-3249367 ) R-HSA-3249371 Reaction Name: TBK1 phosphorylates STAT6 at Ser407 See in Reactome R-HSA-3249378 ( R-HSA-1834941; R-HSA-3249367 ) R-HSA-3249378 Reaction Name: STING recruits TBK1 and STAT6 See in Reactome R-HSA-3249386 ( R-HSA-3134975 ) R-HSA-3249386 Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 See in Reactome R-HSA-3249390 ( R-HSA-1834941; R-HSA-3249367 ) R-HSA-3249390 Reaction Name: TBK1 is phosphorylated within STING:TBK1:STAT6 complex See in Reactome R-HSA-3249392 ( R-HSA-3134975 ) R-HSA-3249392 Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 See in Reactome R-HSA-8948703 ( R-HSA-3134975 ) R-HSA-8948703 Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 See in Reactome R-HSA-8948709 ( R-HSA-3134975 ) R-HSA-8948709 Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 See in Reactome R-HSA-9008684 ( R-HSA-9008059 ) R-HSA-9008684 Reaction Name: TBK1 phosphorylation See in Reactome R-HSA-9013978 ( R-HSA-9013973 ) R-HSA-9013978 Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex See in Reactome R-HSA-9013979 ( R-HSA-9013973 ) R-HSA-9013979 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 See in Reactome R-HSA-9013986 ( R-HSA-9013973 ) R-HSA-9013986 Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-936941 ( R-HSA-936964 ) R-HSA-936941 Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation See in Reactome R-HSA-937337 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937337 Reaction Name: TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination See in Reactome R-HSA-9679819 ( R-HSA-1606341 ) R-HSA-9679819 Reaction Name: TBK1 binds amlexanox See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-9709831 ( R-HSA-168928 ) R-HSA-9709831 Reaction Name: HSP90 binds TBK1 and IRF3 See in Reactome R-HSA-9709852 ( R-HSA-168928 ) R-HSA-9709852 Reaction Name: MAVS:TOMM70 recruits HSP90:TBK1:IRF3 See in Reactome
MONDO:0014809	DDX41	Q9UJV9	3.6.4.13	R-HSA-3270619 R-HSA-3270619 Reactome Name: IRF3-mediated induction of type I IFN See in Reactome R-HSA-1834941 R-HSA-1834941 Reactome Name: STING mediated induction of host immune responses See in Reactome R-HSA-3134975 R-HSA-3134975 Reactome Name: Regulation of innate immune responses to cytosolic DNA See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome	Immune System	R-HSA-1834939 ( R-HSA-1834941; R-HSA-3270619 ) R-HSA-1834939 Reaction Name: STING recruits TBK1 and IRF3 See in Reactome R-HSA-3134822 ( R-HSA-1834941 ) R-HSA-3134822 Reaction Name: DDX41 binds viral dsDNA See in Reactome R-HSA-3134946 ( R-HSA-3134975 ) R-HSA-3134946 Reaction Name: DDX41 ubiquitination by TRIM21 See in Reactome R-HSA-9013869 ( R-HSA-1834941 ) R-HSA-9013869 Reaction Name: DDX41 binds bacterial c-di-AMP, c-di-GMP See in Reactome
MONDO:0054754	TBK1	Q9UHD2	2.7.11.1	R-HSA-3270619 R-HSA-3270619 Reactome Name: IRF3-mediated induction of type I IFN See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-3134975 R-HSA-3134975 Reactome Name: Regulation of innate immune responses to cytosolic DNA See in Reactome R-HSA-9013973 R-HSA-9013973 Reactome Name: TICAM1-dependent activation of IRF3/IRF7 See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-1606341 R-HSA-1606341 Reactome Name: IRF3 mediated activation of type 1 IFN See in Reactome R-HSA-3249367 R-HSA-3249367 Reactome Name: STAT6-mediated induction of chemokines See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-1606322 R-HSA-1606322 Reactome Name: ZBP1(DAI) mediated induction of type I IFNs See in Reactome R-HSA-1834941 R-HSA-1834941 Reactome Name: STING mediated induction of host immune responses See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome	Immune System	R-HSA-1606324 ( R-HSA-1606341 ) R-HSA-1606324 Reaction Name: Recruitment TBK1 to dsDNA:ZBP1 followed by its activation See in Reactome R-HSA-1606327 ( R-HSA-1606341 ) R-HSA-1606327 Reaction Name: Phosphorylation and release of IRF3 See in Reactome R-HSA-1606345 ( R-HSA-1606341 ) R-HSA-1606345 Reaction Name: Recruitment of IRF3 to activated ZBP1:TBK1 See in Reactome R-HSA-166245 ( R-HSA-936964 ) R-HSA-166245 Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-1834939 ( R-HSA-1834941; R-HSA-3270619 ) R-HSA-1834939 Reaction Name: STING recruits TBK1 and IRF3 See in Reactome R-HSA-2396002 ( R-HSA-1834941; R-HSA-3270619 ) R-HSA-2396002 Reaction Name: TBK1 is phosphorylated within STING:TBK1:IRF3 complex See in Reactome R-HSA-2396007 ( R-HSA-1834941; R-HSA-3270619 ) R-HSA-2396007 Reaction Name: IRF3 is phosphorylated by TBK1 See in Reactome R-HSA-3249371 ( R-HSA-1834941; R-HSA-3249367 ) R-HSA-3249371 Reaction Name: TBK1 phosphorylates STAT6 at Ser407 See in Reactome R-HSA-3249378 ( R-HSA-1834941; R-HSA-3249367 ) R-HSA-3249378 Reaction Name: STING recruits TBK1 and STAT6 See in Reactome R-HSA-3249386 ( R-HSA-3134975 ) R-HSA-3249386 Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 See in Reactome R-HSA-3249390 ( R-HSA-1834941; R-HSA-3249367 ) R-HSA-3249390 Reaction Name: TBK1 is phosphorylated within STING:TBK1:STAT6 complex See in Reactome R-HSA-3249392 ( R-HSA-3134975 ) R-HSA-3249392 Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 See in Reactome R-HSA-8948703 ( R-HSA-3134975 ) R-HSA-8948703 Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 See in Reactome R-HSA-8948709 ( R-HSA-3134975 ) R-HSA-8948709 Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 See in Reactome R-HSA-9008684 ( R-HSA-9008059 ) R-HSA-9008684 Reaction Name: TBK1 phosphorylation See in Reactome R-HSA-9013978 ( R-HSA-9013973 ) R-HSA-9013978 Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex See in Reactome R-HSA-9013979 ( R-HSA-9013973 ) R-HSA-9013979 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 See in Reactome R-HSA-9013986 ( R-HSA-9013973 ) R-HSA-9013986 Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-936941 ( R-HSA-936964 ) R-HSA-936941 Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation See in Reactome R-HSA-937337 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937337 Reaction Name: TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination See in Reactome R-HSA-9679819 ( R-HSA-1606341 ) R-HSA-9679819 Reaction Name: TBK1 binds amlexanox See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-9709831 ( R-HSA-168928 ) R-HSA-9709831 Reaction Name: HSP90 binds TBK1 and IRF3 See in Reactome R-HSA-9709852 ( R-HSA-168928 ) R-HSA-9709852 Reaction Name: MAVS:TOMM70 recruits HSP90:TBK1:IRF3 See in Reactome