DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-2871837)

Number of enzymes:	8
Number of disease:	10
Number of reactomes:	87
Number of reactions:	214

Search results (Reactome ID: R-HSA-2871837)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0008005	MAP3K7	O43318	2.7.11.25	R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-450302 R-HSA-450302 Reactome Name: activated TAK1 mediates p38 MAPK activation See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-937042 R-HSA-937042 Reactome Name: IRAK2 mediated activation of TAK1 complex See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-9645460 R-HSA-9645460 Reactome Name: Alpha-protein kinase 1 signaling pathway See in Reactome R-HSA-445989 R-HSA-445989 Reactome Name: TAK1-dependent IKK and NF-kappa-B activation See in Reactome R-HSA-5357956 R-HSA-5357956 Reactome Name: TNFR1-induced NFkappaB signaling pathway See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-9014325 R-HSA-9014325 Reactome Name: TICAM1,TRAF6-dependent induction of TAK1 complex See in Reactome R-HSA-937072 R-HSA-937072 Reactome Name: TRAF6-mediated induction of TAK1 complex within TLR4 complex See in Reactome R-HSA-1169091 R-HSA-1169091 Reactome Name: Activation of NF-kappaB in B cells See in Reactome R-HSA-450321 R-HSA-450321 Reactome Name: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 See in Reactome R-HSA-975163 R-HSA-975163 Reactome Name: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation See in Reactome R-HSA-2871837 R-HSA-2871837 Reactome Name: FCERI mediated NF-kB activation See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome	Immune System Metabolism of proteins Signal Transduction	R-HSA-1168637 ( R-HSA-1169091 ) R-HSA-1168637 Reaction Name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK See in Reactome R-HSA-1168641 ( R-HSA-1169091 ) R-HSA-1168641 Reaction Name: TAK1 associated with the CBM complex phosphorylates IKKbeta See in Reactome R-HSA-168184 ( R-HSA-166058; R-HSA-168638; R-HSA-445989; R-HSA-9020702; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-168184 Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex See in Reactome R-HSA-177690 ( R-HSA-9014325 ) R-HSA-177690 Reaction Name: Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex See in Reactome R-HSA-177692 ( R-HSA-9014325 ) R-HSA-177692 Reaction Name: Activation of recruited TAK1 within the activated TLR3 complex See in Reactome R-HSA-202500 ( R-HSA-202424 ) R-HSA-202500 Reaction Name: Activation of IKK complex See in Reactome R-HSA-202510 ( R-HSA-202424 ) R-HSA-202510 Reaction Name: Activation of TAK1-TAB2 complex See in Reactome R-HSA-2730861 ( R-HSA-2871837 ) R-HSA-2730861 Reaction Name: Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 See in Reactome R-HSA-2730876 ( R-HSA-2871837 ) R-HSA-2730876 Reaction Name: Phosphorylation of IKK-beta by TAK1 See in Reactome R-HSA-2730900 ( R-HSA-2871837 ) R-HSA-2730900 Reaction Name: Activation of TAK1 complex bound to pUb-TRAF6 See in Reactome R-HSA-4332356 ( R-HSA-4086398 ) R-HSA-4332356 Reaction Name: CAMK2 binds MAP3K7 See in Reactome R-HSA-4332388 ( R-HSA-4086398 ) R-HSA-4332388 Reaction Name: Activation of MAP3K7 in response to WNT See in Reactome R-HSA-4411402 ( R-HSA-4086398 ) R-HSA-4411402 Reaction Name: Activation of NLK See in Reactome R-HSA-446870 ( R-HSA-9020702 ) R-HSA-446870 Reaction Name: Polyubiquitinated TRAF6 binds the TAK1 complex See in Reactome R-HSA-450187 ( R-HSA-9020702 ) R-HSA-450187 Reaction Name: TAK1 is activated within the TAK1 complex See in Reactome R-HSA-450337 ( R-HSA-166058; R-HSA-450321; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-450337 Reaction Name: Activated TAK1 phosphorylates MKK4/MKK7 See in Reactome R-HSA-450346 ( R-HSA-166058; R-HSA-450302; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-450346 Reaction Name: activated human TAK1 phosphorylates MKK3/MKK6 See in Reactome R-HSA-5357860 ( R-HSA-5357956 ) R-HSA-5357860 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex See in Reactome R-HSA-5607732 ( R-HSA-5607764 ) R-HSA-5607732 Reaction Name: K63polyUb-TAK1 autophosphorylates See in Reactome R-HSA-5607742 ( R-HSA-5607764 ) R-HSA-5607742 Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta See in Reactome R-HSA-5607757 ( R-HSA-5607764 ) R-HSA-5607757 Reaction Name: K63polyUb-TRAF6 ubiquitinates TAK1 See in Reactome R-HSA-5607759 ( R-HSA-5607764 ) R-HSA-5607759 Reaction Name: TRIKA2 binds K63polyUb-TRAF6 oligomer See in Reactome R-HSA-5696534 ( R-HSA-5689880 ) R-HSA-5696534 Reaction Name: USP18 deubiquitinates TAK1:TAB1 See in Reactome R-HSA-688985 ( R-HSA-168638 ) R-HSA-688985 Reaction Name: K63 polyubiquitinated RIP2 associates with the TAK1 complex See in Reactome R-HSA-706479 ( R-HSA-168638 ) R-HSA-706479 Reaction Name: TAK1 is activated See in Reactome R-HSA-727819 ( R-HSA-168638; R-HSA-9020702 ) R-HSA-727819 Reaction Name: TAK1 phosphorylates MKK6 See in Reactome R-HSA-847070 ( R-HSA-9014325 ) R-HSA-847070 Reaction Name: Phosphorylated TAK1 dissociates from the TLR3 receptor complex See in Reactome R-HSA-936947 ( R-HSA-937072 ) R-HSA-936947 Reaction Name: Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex See in Reactome R-HSA-936951 ( R-HSA-937072 ) R-HSA-936951 Reaction Name: Activation of TAK1 complex bound to activated TLR4 complex See in Reactome R-HSA-936960 ( R-HSA-166058; R-HSA-937042; R-HSA-975871 ) R-HSA-936960 Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex See in Reactome R-HSA-936991 ( R-HSA-166058; R-HSA-937042; R-HSA-975871 ) R-HSA-936991 Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 See in Reactome R-HSA-937075 ( R-HSA-937072 ) R-HSA-937075 Reaction Name: Phosphorylated TAK1 leaves activated TLR receptor complex See in Reactome R-HSA-9645406 ( R-HSA-9645460 ) R-HSA-9645406 Reaction Name: ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) See in Reactome R-HSA-9645442 ( R-HSA-9645460 ) R-HSA-9645442 Reaction Name: Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex See in Reactome R-HSA-975097 ( R-HSA-975138; R-HSA-975155; R-HSA-975163 ) R-HSA-975097 Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation See in Reactome R-HSA-975103 ( R-HSA-975138; R-HSA-975155; R-HSA-975163 ) R-HSA-975103 Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation See in Reactome
MONDO:0013334	CHUK	O15111	2.7.11.10	R-HSA-5684264 R-HSA-5684264 Reactome Name: MAP3K8 (TPL2)-dependent MAPK1/3 activation See in Reactome R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-937039 R-HSA-937039 Reactome Name: IRAK1 recruits IKK complex See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-5607761 R-HSA-5607761 Reactome Name: Dectin-1 mediated noncanonical NF-kB signaling See in Reactome R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-937041 R-HSA-937041 Reactome Name: IKK complex recruitment mediated by RIP1 See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-1236974 R-HSA-1236974 Reactome Name: ER-Phagosome pathway See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome R-HSA-975144 R-HSA-975144 Reactome Name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation See in Reactome R-HSA-445989 R-HSA-445989 Reactome Name: TAK1-dependent IKK and NF-kappa-B activation See in Reactome R-HSA-5357956 R-HSA-5357956 Reactome Name: TNFR1-induced NFkappaB signaling pathway See in Reactome R-HSA-1810476 R-HSA-1810476 Reactome Name: RIP-mediated NFkB activation via ZBP1 See in Reactome R-HSA-5676590 R-HSA-5676590 Reactome Name: NIK-->noncanonical NF-kB signaling See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-1169091 R-HSA-1169091 Reactome Name: Activation of NF-kappaB in B cells See in Reactome R-HSA-168927 R-HSA-168927 Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment See in Reactome R-HSA-2871837 R-HSA-2871837 Reactome Name: FCERI mediated NF-kB activation See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-5668541 R-HSA-5668541 Reactome Name: TNFR2 non-canonical NF-kB pathway See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1606322 R-HSA-1606322 Reactome Name: ZBP1(DAI) mediated induction of type I IFNs See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome	Immune System Signal Transduction	R-HSA-1168637 ( R-HSA-1169091 ) R-HSA-1168637 Reaction Name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK See in Reactome R-HSA-1168638 ( R-HSA-1169091 ) R-HSA-1168638 Reaction Name: Activated IKK phosphorylates I-kappaB See in Reactome R-HSA-1168641 ( R-HSA-1169091 ) R-HSA-1168641 Reaction Name: TAK1 associated with the CBM complex phosphorylates IKKbeta See in Reactome R-HSA-168140 ( R-HSA-166058; R-HSA-1810476; R-HSA-445989; R-HSA-9020702; R-HSA-933542; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-168140 Reaction Name: Active IKK Complex phosphorylates NF-kappa-B inhibitor See in Reactome R-HSA-168184 ( R-HSA-166058; R-HSA-168638; R-HSA-445989; R-HSA-9020702; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-168184 Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex See in Reactome R-HSA-168910 ( R-HSA-1810476 ) R-HSA-168910 Reaction Name: RIP1 facilitates IKK complex phosphorylation See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-202500 ( R-HSA-202424 ) R-HSA-202500 Reaction Name: Activation of IKK complex See in Reactome R-HSA-202534 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-202534 Reaction Name: Ubiquitination of NEMO by TRAF6 See in Reactome R-HSA-202541 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-202541 Reaction Name: p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB See in Reactome R-HSA-2730876 ( R-HSA-2871837 ) R-HSA-2730876 Reaction Name: Phosphorylation of IKK-beta by TAK1 See in Reactome R-HSA-451561 ( R-HSA-9020702 ) R-HSA-451561 Reaction Name: NEMO binds polyubiquitinated IRAK1 See in Reactome R-HSA-5357776 ( R-HSA-5357956 ) R-HSA-5357776 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG See in Reactome R-HSA-5357831 ( R-HSA-5357905 ) R-HSA-5357831 Reaction Name: CYLD is phosphorylated by IKK See in Reactome R-HSA-5607720 ( R-HSA-5607761; R-HSA-5607764; R-HSA-5668541; R-HSA-5676590 ) R-HSA-5607720 Reaction Name: p100:RELB binds active NIK:p-IKKA dimer See in Reactome R-HSA-5607722 ( R-HSA-5607761; R-HSA-5607764; R-HSA-5668541; R-HSA-5676590 ) R-HSA-5607722 Reaction Name: Active NIK phosphorylates IKKA dimer See in Reactome R-HSA-5607723 ( R-HSA-5607761; R-HSA-5607764; R-HSA-5668541; R-HSA-5676590 ) R-HSA-5607723 Reaction Name: SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB See in Reactome R-HSA-5607725 ( R-HSA-5607761; R-HSA-5607764; R-HSA-5668541; R-HSA-5676590 ) R-HSA-5607725 Reaction Name: SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP See in Reactome R-HSA-5607726 ( R-HSA-5607761; R-HSA-5607764; R-HSA-5668541; R-HSA-5676590 ) R-HSA-5607726 Reaction Name: Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB See in Reactome R-HSA-5607742 ( R-HSA-5607764 ) R-HSA-5607742 Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta See in Reactome R-HSA-5609665 ( R-HSA-166058; R-HSA-445989; R-HSA-9020702; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-5609665 Reaction Name: CHUK, IKBKB and IKBKG form IKK complex See in Reactome R-HSA-5626962 ( R-HSA-5357905 ) R-HSA-5626962 Reaction Name: GNB2L1 binds IKKA:IKKB:NEMO See in Reactome R-HSA-5684267 ( R-HSA-166058; R-HSA-5684264; R-HSA-9020702; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-5684267 Reaction Name: IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex See in Reactome R-HSA-5684275 ( R-HSA-166058; R-HSA-5684264; R-HSA-9020702; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-5684275 Reaction Name: IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 See in Reactome R-HSA-8863895 ( R-HSA-1236974 ) R-HSA-8863895 Reaction Name: IKKB phosphorylates SNAP23 See in Reactome R-HSA-9014343 ( R-HSA-168927 ) R-HSA-9014343 Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex See in Reactome R-HSA-933530 ( R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933539 ( R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-937029 ( R-HSA-937041 ) R-HSA-937029 Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1 See in Reactome R-HSA-937032 ( R-HSA-166058; R-HSA-937039; R-HSA-975871 ) R-HSA-937032 Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 See in Reactome R-HSA-975119 ( R-HSA-975138; R-HSA-975144; R-HSA-975155 ) R-HSA-975119 Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. See in Reactome
MONDO:0014197	MALT1	Q9UDY8	3.4.22.-	R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-1169091 R-HSA-1169091 Reactome Name: Activation of NF-kappaB in B cells See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-5660668 R-HSA-5660668 Reactome Name: CLEC7A/inflammasome pathway See in Reactome R-HSA-2871837 R-HSA-2871837 Reactome Name: FCERI mediated NF-kB activation See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome	Immune System	R-HSA-1168637 ( R-HSA-1169091 ) R-HSA-1168637 Reaction Name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK See in Reactome R-HSA-1168641 ( R-HSA-1169091 ) R-HSA-1168641 Reaction Name: TAK1 associated with the CBM complex phosphorylates IKKbeta See in Reactome R-HSA-1168644 ( R-HSA-1169091 ) R-HSA-1168644 Reaction Name: CARMA1 recruits MALT1 and BCL10 forming CBM Complex See in Reactome R-HSA-202453 ( R-HSA-202424 ) R-HSA-202453 Reaction Name: Auto-ubiquitination of TRAF6 See in Reactome R-HSA-202472 ( R-HSA-202424 ) R-HSA-202472 Reaction Name: Translocation of TRAF6 to CBM complex See in Reactome R-HSA-202478 ( R-HSA-202424 ) R-HSA-202478 Reaction Name: Interaction and oligomerization of MALT1 to Bcl10 See in Reactome R-HSA-202500 ( R-HSA-202424 ) R-HSA-202500 Reaction Name: Activation of IKK complex See in Reactome R-HSA-202510 ( R-HSA-202424 ) R-HSA-202510 Reaction Name: Activation of TAK1-TAB2 complex See in Reactome R-HSA-202534 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-202534 Reaction Name: Ubiquitination of NEMO by TRAF6 See in Reactome R-HSA-2730836 ( R-HSA-2871837 ) R-HSA-2730836 Reaction Name: Interaction of BCL10:MALT1 with CARMA1 to form CBM complex See in Reactome R-HSA-2730861 ( R-HSA-2871837 ) R-HSA-2730861 Reaction Name: Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 See in Reactome R-HSA-2730864 ( R-HSA-2871837 ) R-HSA-2730864 Reaction Name: Recruitment of TRAF6 to CBM complex by binding to MALT1 See in Reactome R-HSA-2730876 ( R-HSA-2871837 ) R-HSA-2730876 Reaction Name: Phosphorylation of IKK-beta by TAK1 See in Reactome R-HSA-2730899 ( R-HSA-2871837 ) R-HSA-2730899 Reaction Name: Oligomerization of BCL10 and MALT1 See in Reactome R-HSA-2730900 ( R-HSA-2871837 ) R-HSA-2730900 Reaction Name: Activation of TAK1 complex bound to pUb-TRAF6 See in Reactome R-HSA-2730903 ( R-HSA-2871837 ) R-HSA-2730903 Reaction Name: Oligomerization of TRAF6 See in Reactome R-HSA-2730904 ( R-HSA-2871837 ) R-HSA-2730904 Reaction Name: Auto-ubiquitination of TRAF6 See in Reactome R-HSA-5607732 ( R-HSA-5607764 ) R-HSA-5607732 Reaction Name: K63polyUb-TAK1 autophosphorylates See in Reactome R-HSA-5607736 ( R-HSA-5607764 ) R-HSA-5607736 Reaction Name: MALT1 oligomerizes See in Reactome R-HSA-5607742 ( R-HSA-5607764 ) R-HSA-5607742 Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta See in Reactome R-HSA-5607744 ( R-HSA-5607764 ) R-HSA-5607744 Reaction Name: MALT1 binds BCL10 See in Reactome R-HSA-5607747 ( R-HSA-5607764 ) R-HSA-5607747 Reaction Name: TRAF6 binds MALT1 oligomers See in Reactome R-HSA-5607751 ( R-HSA-5607764 ) R-HSA-5607751 Reaction Name: TRAF6 oligomerizes See in Reactome R-HSA-5607756 ( R-HSA-5607764 ) R-HSA-5607756 Reaction Name: TRAF6 oligomer autoubiquitinates See in Reactome R-HSA-5607757 ( R-HSA-5607764 ) R-HSA-5607757 Reaction Name: K63polyUb-TRAF6 ubiquitinates TAK1 See in Reactome R-HSA-5607759 ( R-HSA-5607764 ) R-HSA-5607759 Reaction Name: TRIKA2 binds K63polyUb-TRAF6 oligomer See in Reactome R-HSA-5660662 ( R-HSA-5607764; R-HSA-5660668 ) R-HSA-5660662 Reaction Name: ASC binds Caspase-8 complex See in Reactome R-HSA-5660663 ( R-HSA-5607764; R-HSA-5660668 ) R-HSA-5660663 Reaction Name: Caspase-8 cleaves IL1B precursor See in Reactome R-HSA-5660665 ( R-HSA-5607764; R-HSA-5660668 ) R-HSA-5660665 Reaction Name: Caspase-8 binds MALT See in Reactome
MONDO:0014267	IKBKB	O14920	2.7.11.10 2.7.11.1	R-HSA-5684264 R-HSA-5684264 Reactome Name: MAP3K8 (TPL2)-dependent MAPK1/3 activation See in Reactome R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-937039 R-HSA-937039 Reactome Name: IRAK1 recruits IKK complex See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-937041 R-HSA-937041 Reactome Name: IKK complex recruitment mediated by RIP1 See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-1236974 R-HSA-1236974 Reactome Name: ER-Phagosome pathway See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome R-HSA-975144 R-HSA-975144 Reactome Name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation See in Reactome R-HSA-445989 R-HSA-445989 Reactome Name: TAK1-dependent IKK and NF-kappa-B activation See in Reactome R-HSA-5357956 R-HSA-5357956 Reactome Name: TNFR1-induced NFkappaB signaling pathway See in Reactome R-HSA-1810476 R-HSA-1810476 Reactome Name: RIP-mediated NFkB activation via ZBP1 See in Reactome R-HSA-209543 R-HSA-209543 Reactome Name: p75NTR recruits signalling complexes See in Reactome R-HSA-209560 R-HSA-209560 Reactome Name: NF-kB is activated and signals survival See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-1169091 R-HSA-1169091 Reactome Name: Activation of NF-kappaB in B cells See in Reactome R-HSA-168927 R-HSA-168927 Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment See in Reactome R-HSA-2871837 R-HSA-2871837 Reactome Name: FCERI mediated NF-kB activation See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1606322 R-HSA-1606322 Reactome Name: ZBP1(DAI) mediated induction of type I IFNs See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-193639 R-HSA-193639 Reactome Name: p75NTR signals via NF-kB See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome	Immune System Signal Transduction	R-HSA-1168637 ( R-HSA-1169091 ) R-HSA-1168637 Reaction Name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK See in Reactome R-HSA-1168638 ( R-HSA-1169091 ) R-HSA-1168638 Reaction Name: Activated IKK phosphorylates I-kappaB See in Reactome R-HSA-1168641 ( R-HSA-1169091 ) R-HSA-1168641 Reaction Name: TAK1 associated with the CBM complex phosphorylates IKKbeta See in Reactome R-HSA-168140 ( R-HSA-166058; R-HSA-1810476; R-HSA-445989; R-HSA-9020702; R-HSA-933542; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-168140 Reaction Name: Active IKK Complex phosphorylates NF-kappa-B inhibitor See in Reactome R-HSA-168184 ( R-HSA-166058; R-HSA-168638; R-HSA-445989; R-HSA-9020702; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-168184 Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex See in Reactome R-HSA-168910 ( R-HSA-1810476 ) R-HSA-168910 Reaction Name: RIP1 facilitates IKK complex phosphorylation See in Reactome R-HSA-193641 ( R-HSA-209543 ) R-HSA-193641 Reaction Name: IKK-beta is recruited See in Reactome R-HSA-193703 ( R-HSA-209560 ) R-HSA-193703 Reaction Name: IKKbeta is activated See in Reactome R-HSA-193705 ( R-HSA-209560 ) R-HSA-193705 Reaction Name: IKKbeta phosphorylates IkB causing NF-kB to dissociate See in Reactome R-HSA-202500 ( R-HSA-202424 ) R-HSA-202500 Reaction Name: Activation of IKK complex See in Reactome R-HSA-202534 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-202534 Reaction Name: Ubiquitination of NEMO by TRAF6 See in Reactome R-HSA-202541 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-202541 Reaction Name: p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB See in Reactome R-HSA-209087 ( R-HSA-9020702 ) R-HSA-209087 Reaction Name: IKBA is phosphorylated by Phospho IKKB kinase See in Reactome R-HSA-2730876 ( R-HSA-2871837 ) R-HSA-2730876 Reaction Name: Phosphorylation of IKK-beta by TAK1 See in Reactome R-HSA-451561 ( R-HSA-9020702 ) R-HSA-451561 Reaction Name: NEMO binds polyubiquitinated IRAK1 See in Reactome R-HSA-5357776 ( R-HSA-5357956 ) R-HSA-5357776 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG See in Reactome R-HSA-5357831 ( R-HSA-5357905 ) R-HSA-5357831 Reaction Name: CYLD is phosphorylated by IKK See in Reactome R-HSA-5607742 ( R-HSA-5607764 ) R-HSA-5607742 Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta See in Reactome R-HSA-5609665 ( R-HSA-166058; R-HSA-445989; R-HSA-9020702; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-5609665 Reaction Name: CHUK, IKBKB and IKBKG form IKK complex See in Reactome R-HSA-5626962 ( R-HSA-5357905 ) R-HSA-5626962 Reaction Name: GNB2L1 binds IKKA:IKKB:NEMO See in Reactome R-HSA-5684267 ( R-HSA-166058; R-HSA-5684264; R-HSA-9020702; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-5684267 Reaction Name: IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex See in Reactome R-HSA-5684275 ( R-HSA-166058; R-HSA-5684264; R-HSA-9020702; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-5684275 Reaction Name: IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 See in Reactome R-HSA-8863895 ( R-HSA-1236974 ) R-HSA-8863895 Reaction Name: IKKB phosphorylates SNAP23 See in Reactome R-HSA-9014343 ( R-HSA-168927 ) R-HSA-9014343 Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex See in Reactome R-HSA-933530 ( R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933539 ( R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-937029 ( R-HSA-937041 ) R-HSA-937029 Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1 See in Reactome R-HSA-937032 ( R-HSA-166058; R-HSA-937039; R-HSA-975871 ) R-HSA-937032 Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 See in Reactome R-HSA-975119 ( R-HSA-975138; R-HSA-975144; R-HSA-975155 ) R-HSA-975119 Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. See in Reactome
MONDO:0014935	MAP3K7	O43318	2.7.11.25	R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-450302 R-HSA-450302 Reactome Name: activated TAK1 mediates p38 MAPK activation See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-937042 R-HSA-937042 Reactome Name: IRAK2 mediated activation of TAK1 complex See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-9645460 R-HSA-9645460 Reactome Name: Alpha-protein kinase 1 signaling pathway See in Reactome R-HSA-445989 R-HSA-445989 Reactome Name: TAK1-dependent IKK and NF-kappa-B activation See in Reactome R-HSA-5357956 R-HSA-5357956 Reactome Name: TNFR1-induced NFkappaB signaling pathway See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-9014325 R-HSA-9014325 Reactome Name: TICAM1,TRAF6-dependent induction of TAK1 complex See in Reactome R-HSA-937072 R-HSA-937072 Reactome Name: TRAF6-mediated induction of TAK1 complex within TLR4 complex See in Reactome R-HSA-1169091 R-HSA-1169091 Reactome Name: Activation of NF-kappaB in B cells See in Reactome R-HSA-450321 R-HSA-450321 Reactome Name: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 See in Reactome R-HSA-975163 R-HSA-975163 Reactome Name: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation See in Reactome R-HSA-2871837 R-HSA-2871837 Reactome Name: FCERI mediated NF-kB activation See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome	Immune System Metabolism of proteins Signal Transduction	R-HSA-1168637 ( R-HSA-1169091 ) R-HSA-1168637 Reaction Name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK See in Reactome R-HSA-1168641 ( R-HSA-1169091 ) R-HSA-1168641 Reaction Name: TAK1 associated with the CBM complex phosphorylates IKKbeta See in Reactome R-HSA-168184 ( R-HSA-166058; R-HSA-168638; R-HSA-445989; R-HSA-9020702; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-168184 Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex See in Reactome R-HSA-177690 ( R-HSA-9014325 ) R-HSA-177690 Reaction Name: Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex See in Reactome R-HSA-177692 ( R-HSA-9014325 ) R-HSA-177692 Reaction Name: Activation of recruited TAK1 within the activated TLR3 complex See in Reactome R-HSA-202500 ( R-HSA-202424 ) R-HSA-202500 Reaction Name: Activation of IKK complex See in Reactome R-HSA-202510 ( R-HSA-202424 ) R-HSA-202510 Reaction Name: Activation of TAK1-TAB2 complex See in Reactome R-HSA-2730861 ( R-HSA-2871837 ) R-HSA-2730861 Reaction Name: Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 See in Reactome R-HSA-2730876 ( R-HSA-2871837 ) R-HSA-2730876 Reaction Name: Phosphorylation of IKK-beta by TAK1 See in Reactome R-HSA-2730900 ( R-HSA-2871837 ) R-HSA-2730900 Reaction Name: Activation of TAK1 complex bound to pUb-TRAF6 See in Reactome R-HSA-4332356 ( R-HSA-4086398 ) R-HSA-4332356 Reaction Name: CAMK2 binds MAP3K7 See in Reactome R-HSA-4332388 ( R-HSA-4086398 ) R-HSA-4332388 Reaction Name: Activation of MAP3K7 in response to WNT See in Reactome R-HSA-4411402 ( R-HSA-4086398 ) R-HSA-4411402 Reaction Name: Activation of NLK See in Reactome R-HSA-446870 ( R-HSA-9020702 ) R-HSA-446870 Reaction Name: Polyubiquitinated TRAF6 binds the TAK1 complex See in Reactome R-HSA-450187 ( R-HSA-9020702 ) R-HSA-450187 Reaction Name: TAK1 is activated within the TAK1 complex See in Reactome R-HSA-450337 ( R-HSA-166058; R-HSA-450321; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-450337 Reaction Name: Activated TAK1 phosphorylates MKK4/MKK7 See in Reactome R-HSA-450346 ( R-HSA-166058; R-HSA-450302; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-450346 Reaction Name: activated human TAK1 phosphorylates MKK3/MKK6 See in Reactome R-HSA-5357860 ( R-HSA-5357956 ) R-HSA-5357860 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex See in Reactome R-HSA-5607732 ( R-HSA-5607764 ) R-HSA-5607732 Reaction Name: K63polyUb-TAK1 autophosphorylates See in Reactome R-HSA-5607742 ( R-HSA-5607764 ) R-HSA-5607742 Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta See in Reactome R-HSA-5607757 ( R-HSA-5607764 ) R-HSA-5607757 Reaction Name: K63polyUb-TRAF6 ubiquitinates TAK1 See in Reactome R-HSA-5607759 ( R-HSA-5607764 ) R-HSA-5607759 Reaction Name: TRIKA2 binds K63polyUb-TRAF6 oligomer See in Reactome R-HSA-5696534 ( R-HSA-5689880 ) R-HSA-5696534 Reaction Name: USP18 deubiquitinates TAK1:TAB1 See in Reactome R-HSA-688985 ( R-HSA-168638 ) R-HSA-688985 Reaction Name: K63 polyubiquitinated RIP2 associates with the TAK1 complex See in Reactome R-HSA-706479 ( R-HSA-168638 ) R-HSA-706479 Reaction Name: TAK1 is activated See in Reactome R-HSA-727819 ( R-HSA-168638; R-HSA-9020702 ) R-HSA-727819 Reaction Name: TAK1 phosphorylates MKK6 See in Reactome R-HSA-847070 ( R-HSA-9014325 ) R-HSA-847070 Reaction Name: Phosphorylated TAK1 dissociates from the TLR3 receptor complex See in Reactome R-HSA-936947 ( R-HSA-937072 ) R-HSA-936947 Reaction Name: Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex See in Reactome R-HSA-936951 ( R-HSA-937072 ) R-HSA-936951 Reaction Name: Activation of TAK1 complex bound to activated TLR4 complex See in Reactome R-HSA-936960 ( R-HSA-166058; R-HSA-937042; R-HSA-975871 ) R-HSA-936960 Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex See in Reactome R-HSA-936991 ( R-HSA-166058; R-HSA-937042; R-HSA-975871 ) R-HSA-936991 Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 See in Reactome R-HSA-937075 ( R-HSA-937072 ) R-HSA-937075 Reaction Name: Phosphorylated TAK1 leaves activated TLR receptor complex See in Reactome R-HSA-9645406 ( R-HSA-9645460 ) R-HSA-9645406 Reaction Name: ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) See in Reactome R-HSA-9645442 ( R-HSA-9645460 ) R-HSA-9645442 Reaction Name: Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex See in Reactome R-HSA-975097 ( R-HSA-975138; R-HSA-975155; R-HSA-975163 ) R-HSA-975097 Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation See in Reactome R-HSA-975103 ( R-HSA-975138; R-HSA-975155; R-HSA-975163 ) R-HSA-975103 Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation See in Reactome
MONDO:0015884	TRAF6	Q9Y4K3	2.3.2.27	R-HSA-937042 R-HSA-937042 Reactome Name: IRAK2 mediated activation of TAK1 complex See in Reactome R-HSA-937041 R-HSA-937041 Reactome Name: IKK complex recruitment mediated by RIP1 See in Reactome R-HSA-937072 R-HSA-937072 Reactome Name: TRAF6-mediated induction of TAK1 complex within TLR4 complex See in Reactome R-HSA-168927 R-HSA-168927 Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment See in Reactome R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-975144 R-HSA-975144 Reactome Name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation See in Reactome R-HSA-975163 R-HSA-975163 Reactome Name: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation See in Reactome R-HSA-209543 R-HSA-209543 Reactome Name: p75NTR recruits signalling complexes See in Reactome R-HSA-209560 R-HSA-209560 Reactome Name: NF-kB is activated and signals survival See in Reactome R-HSA-450321 R-HSA-450321 Reactome Name: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 See in Reactome R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-450302 R-HSA-450302 Reactome Name: activated TAK1 mediates p38 MAPK activation See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-9645460 R-HSA-9645460 Reactome Name: Alpha-protein kinase 1 signaling pathway See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-445989 R-HSA-445989 Reactome Name: TAK1-dependent IKK and NF-kappa-B activation See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-937039 R-HSA-937039 Reactome Name: IRAK1 recruits IKK complex See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-975110 R-HSA-975110 Reactome Name: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-9014325 R-HSA-9014325 Reactome Name: TICAM1,TRAF6-dependent induction of TAK1 complex See in Reactome R-HSA-2871837 R-HSA-2871837 Reactome Name: FCERI mediated NF-kB activation See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-193639 R-HSA-193639 Reactome Name: p75NTR signals via NF-kB See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome	Immune System Metabolism of proteins Signal Transduction	R-HSA-166362 ( R-HSA-166058 ) R-HSA-166362 Reaction Name: Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-166363 ( R-HSA-166058 ) R-HSA-166363 Reaction Name: TRAF6 binds to hp- IRAK1 See in Reactome R-HSA-166869 ( R-HSA-166058; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-166869 Reaction Name: TRAF6 binds MEKK1 See in Reactome R-HSA-168184 ( R-HSA-166058; R-HSA-168638; R-HSA-445989; R-HSA-9020702; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-168184 Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex See in Reactome R-HSA-168915 ( R-HSA-937041 ) R-HSA-168915 Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex See in Reactome R-HSA-177690 ( R-HSA-9014325 ) R-HSA-177690 Reaction Name: Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex See in Reactome R-HSA-177692 ( R-HSA-9014325 ) R-HSA-177692 Reaction Name: Activation of recruited TAK1 within the activated TLR3 complex See in Reactome R-HSA-177694 ( R-HSA-9014325 ) R-HSA-177694 Reaction Name: Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6 See in Reactome R-HSA-193641 ( R-HSA-209543 ) R-HSA-193641 Reaction Name: IKK-beta is recruited See in Reactome R-HSA-193665 ( R-HSA-209543 ) R-HSA-193665 Reaction Name: MYD88 dissociates See in Reactome R-HSA-193669 ( R-HSA-205043 ) R-HSA-193669 Reaction Name: TRAF6 binds to p75NTR:NRIF See in Reactome R-HSA-193684 ( R-HSA-209543 ) R-HSA-193684 Reaction Name: p62 recruits an atypical PKC See in Reactome R-HSA-193694 ( R-HSA-209543 ) R-HSA-193694 Reaction Name: p62 is recruited and forms a complex with TRAF6 See in Reactome R-HSA-193695 ( R-HSA-209543 ) R-HSA-193695 Reaction Name: IRAK interacts with TRAF6 See in Reactome R-HSA-193700 ( R-HSA-193692 ) R-HSA-193700 Reaction Name: p75NTR ICD signals to NF-kB See in Reactome R-HSA-193703 ( R-HSA-209560 ) R-HSA-193703 Reaction Name: IKKbeta is activated See in Reactome R-HSA-193705 ( R-HSA-209560 ) R-HSA-193705 Reaction Name: IKKbeta phosphorylates IkB causing NF-kB to dissociate See in Reactome R-HSA-202453 ( R-HSA-202424 ) R-HSA-202453 Reaction Name: Auto-ubiquitination of TRAF6 See in Reactome R-HSA-202472 ( R-HSA-202424 ) R-HSA-202472 Reaction Name: Translocation of TRAF6 to CBM complex See in Reactome R-HSA-202500 ( R-HSA-202424 ) R-HSA-202500 Reaction Name: Activation of IKK complex See in Reactome R-HSA-202510 ( R-HSA-202424 ) R-HSA-202510 Reaction Name: Activation of TAK1-TAB2 complex See in Reactome R-HSA-202534 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-202534 Reaction Name: Ubiquitination of NEMO by TRAF6 See in Reactome R-HSA-204949 ( R-HSA-205043 ) R-HSA-204949 Reaction Name: NRIF and TRAF6 may activate JNK See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-205118 ( R-HSA-205043 ) R-HSA-205118 Reaction Name: TRAF6 polyubiquitinates NRIF See in Reactome R-HSA-209566 ( R-HSA-209543 ) R-HSA-209566 Reaction Name: TRAF6 is auto-ubiquitinated See in Reactome R-HSA-2262775 ( R-HSA-166058 ) R-HSA-2262775 Reaction Name: Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-2262777 ( R-HSA-166058 ) R-HSA-2262777 Reaction Name: TRAF6 binds to p-IRAK2 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2730861 ( R-HSA-2871837 ) R-HSA-2730861 Reaction Name: Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 See in Reactome R-HSA-2730864 ( R-HSA-2871837 ) R-HSA-2730864 Reaction Name: Recruitment of TRAF6 to CBM complex by binding to MALT1 See in Reactome R-HSA-2730876 ( R-HSA-2871837 ) R-HSA-2730876 Reaction Name: Phosphorylation of IKK-beta by TAK1 See in Reactome R-HSA-2730900 ( R-HSA-2871837 ) R-HSA-2730900 Reaction Name: Activation of TAK1 complex bound to pUb-TRAF6 See in Reactome R-HSA-2730903 ( R-HSA-2871837 ) R-HSA-2730903 Reaction Name: Oligomerization of TRAF6 See in Reactome R-HSA-2730904 ( R-HSA-2871837 ) R-HSA-2730904 Reaction Name: Auto-ubiquitination of TRAF6 See in Reactome R-HSA-446862 ( R-HSA-9020702 ) R-HSA-446862 Reaction Name: Hyperphosphorylated IRAK1 associates with TRAF6 See in Reactome R-HSA-446870 ( R-HSA-9020702 ) R-HSA-446870 Reaction Name: Polyubiquitinated TRAF6 binds the TAK1 complex See in Reactome R-HSA-446877 ( R-HSA-9020702 ) R-HSA-446877 Reaction Name: TRAF6 is K63 poly-ubiquitinated See in Reactome R-HSA-446894 ( R-HSA-9020702 ) R-HSA-446894 Reaction Name: TRAF6 binding leads to IRAK1:TRAF6 release See in Reactome R-HSA-450173 ( R-HSA-9020702 ) R-HSA-450173 Reaction Name: IRAK1 induces oligomerisation of TRAF6 See in Reactome R-HSA-450187 ( R-HSA-9020702 ) R-HSA-450187 Reaction Name: TAK1 is activated within the TAK1 complex See in Reactome R-HSA-450259 ( R-HSA-9014325 ) R-HSA-450259 Reaction Name: Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex See in Reactome R-HSA-450337 ( R-HSA-166058; R-HSA-450321; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-450337 Reaction Name: Activated TAK1 phosphorylates MKK4/MKK7 See in Reactome R-HSA-450346 ( R-HSA-166058; R-HSA-450302; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-450346 Reaction Name: activated human TAK1 phosphorylates MKK3/MKK6 See in Reactome R-HSA-450358 ( R-HSA-937072; R-HSA-975138; R-HSA-975155; R-HSA-975163 ) R-HSA-450358 Reaction Name: Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation See in Reactome R-HSA-507719 ( R-HSA-9020702 ) R-HSA-507719 Reaction Name: p62:MEKK3 binds to TRAF6 See in Reactome R-HSA-5607732 ( R-HSA-5607764 ) R-HSA-5607732 Reaction Name: K63polyUb-TAK1 autophosphorylates See in Reactome R-HSA-5607742 ( R-HSA-5607764 ) R-HSA-5607742 Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta See in Reactome R-HSA-5607747 ( R-HSA-5607764 ) R-HSA-5607747 Reaction Name: TRAF6 binds MALT1 oligomers See in Reactome R-HSA-5607751 ( R-HSA-5607764 ) R-HSA-5607751 Reaction Name: TRAF6 oligomerizes See in Reactome R-HSA-5607756 ( R-HSA-5607764 ) R-HSA-5607756 Reaction Name: TRAF6 oligomer autoubiquitinates See in Reactome R-HSA-5607757 ( R-HSA-5607764 ) R-HSA-5607757 Reaction Name: K63polyUb-TRAF6 ubiquitinates TAK1 See in Reactome R-HSA-5607759 ( R-HSA-5607764 ) R-HSA-5607759 Reaction Name: TRIKA2 binds K63polyUb-TRAF6 oligomer See in Reactome R-HSA-5690843 ( R-HSA-5689896 ) R-HSA-5690843 Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA See in Reactome R-HSA-5690870 ( R-HSA-5689896 ) R-HSA-5690870 Reaction Name: OTUD7B,TNFAIP3 deubiquitinate TRAF6 See in Reactome R-HSA-5696627 ( R-HSA-5689880 ) R-HSA-5696627 Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG See in Reactome R-HSA-688137 ( R-HSA-168638 ) R-HSA-688137 Reaction Name: RIP2 is K63 polyubiquitinated See in Reactome R-HSA-741386 ( R-HSA-168638 ) R-HSA-741386 Reaction Name: RIP2 induces K63-linked ubiquitination of NEMO See in Reactome R-HSA-847070 ( R-HSA-9014325 ) R-HSA-847070 Reaction Name: Phosphorylated TAK1 dissociates from the TLR3 receptor complex See in Reactome R-HSA-8869456 ( R-HSA-5689880 ) R-HSA-8869456 Reaction Name: USP4 deubiquitinate TRAF2,TRAF6 See in Reactome R-HSA-8869506 ( R-HSA-5689896 ) R-HSA-8869506 Reaction Name: TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 See in Reactome R-HSA-8948015 ( R-HSA-9020702 ) R-HSA-8948015 Reaction Name: hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb See in Reactome R-HSA-8948018 ( R-HSA-9020702 ) R-HSA-8948018 Reaction Name: UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 See in Reactome R-HSA-9014342 ( R-HSA-168927 ) R-HSA-9014342 Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex See in Reactome R-HSA-918230 ( R-HSA-933541 ) R-HSA-918230 Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1 See in Reactome R-HSA-933525 ( R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933527 ( R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933528 ( R-HSA-933542 ) R-HSA-933528 Reaction Name: Interaction of MEKK1 with TRAF6 See in Reactome R-HSA-933530 ( R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933537 ( R-HSA-933541 ) R-HSA-933537 Reaction Name: Recruitment of TANK to TRAF6 See in Reactome R-HSA-933538 ( R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-936942 ( R-HSA-166058; R-HSA-937042; R-HSA-975871 ) R-HSA-936942 Reaction Name: Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 See in Reactome R-HSA-936947 ( R-HSA-937072 ) R-HSA-936947 Reaction Name: Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex See in Reactome R-HSA-936951 ( R-HSA-937072 ) R-HSA-936951 Reaction Name: Activation of TAK1 complex bound to activated TLR4 complex See in Reactome R-HSA-936952 ( R-HSA-937072 ) R-HSA-936952 Reaction Name: Auto ubiquitination of TRAF6 bound to the activated TLR4 complex See in Reactome R-HSA-936960 ( R-HSA-166058; R-HSA-937042; R-HSA-975871 ) R-HSA-936960 Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex See in Reactome R-HSA-936963 ( R-HSA-166058; R-HSA-937042; R-HSA-975871 ) R-HSA-936963 Reaction Name: IRAK2 induces TRAF6 oligomerization See in Reactome R-HSA-936985 ( R-HSA-937072 ) R-HSA-936985 Reaction Name: Activated TLR4:TICAM1 recruits TRAF6 See in Reactome R-HSA-936986 ( R-HSA-166058; R-HSA-937042; R-HSA-975871 ) R-HSA-936986 Reaction Name: Activated TRAF6 synthesizes unanchored polyubiquitin chains See in Reactome R-HSA-936991 ( R-HSA-166058; R-HSA-937042; R-HSA-975871 ) R-HSA-936991 Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 See in Reactome R-HSA-937032 ( R-HSA-166058; R-HSA-937039; R-HSA-975871 ) R-HSA-937032 Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 See in Reactome R-HSA-937034 ( R-HSA-166058; R-HSA-937039; R-HSA-975871 ) R-HSA-937034 Reaction Name: IRAK1 phosphorylates Pellino See in Reactome R-HSA-937044 ( R-HSA-166058; R-HSA-937039; R-HSA-975871 ) R-HSA-937044 Reaction Name: Pellino binds hp-IRAK1:TRAF6 See in Reactome R-HSA-937050 ( R-HSA-166058; R-HSA-937039; R-HSA-975871 ) R-HSA-937050 Reaction Name: Pellino ubiquitinates hp-IRAK1 See in Reactome R-HSA-937075 ( R-HSA-937072 ) R-HSA-937075 Reaction Name: Phosphorylated TAK1 leaves activated TLR receptor complex See in Reactome R-HSA-9628444 ( R-HSA-9014325 ) R-HSA-9628444 Reaction Name: Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation See in Reactome R-HSA-9645394 ( R-HSA-9645460 ) R-HSA-9645394 Reaction Name: Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation See in Reactome R-HSA-9645406 ( R-HSA-9645460 ) R-HSA-9645406 Reaction Name: ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) See in Reactome R-HSA-9645414 ( R-HSA-9645460 ) R-HSA-9645414 Reaction Name: Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer See in Reactome R-HSA-9645442 ( R-HSA-9645460 ) R-HSA-9645442 Reaction Name: Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex See in Reactome R-HSA-9645501 ( R-HSA-9645460 ) R-HSA-9645501 Reaction Name: TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex See in Reactome R-HSA-9645520 ( R-HSA-9645460 ) R-HSA-9645520 Reaction Name: ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 See in Reactome R-HSA-9705145 ( R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705323 ( R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-975097 ( R-HSA-975138; R-HSA-975155; R-HSA-975163 ) R-HSA-975097 Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation See in Reactome R-HSA-975100 ( R-HSA-975138; R-HSA-975155 ) R-HSA-975100 Reaction Name: Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex See in Reactome R-HSA-975103 ( R-HSA-975138; R-HSA-975155; R-HSA-975163 ) R-HSA-975103 Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation See in Reactome R-HSA-975106 ( R-HSA-975110; R-HSA-975155 ) R-HSA-975106 Reaction Name: Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation See in Reactome R-HSA-975111 ( R-HSA-975155 ) R-HSA-975111 Reaction Name: TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 See in Reactome R-HSA-975118 ( R-HSA-975110; R-HSA-975155 ) R-HSA-975118 Reaction Name: TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex See in Reactome R-HSA-975119 ( R-HSA-975138; R-HSA-975144; R-HSA-975155 ) R-HSA-975119 Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. See in Reactome R-HSA-975122 ( R-HSA-975138; R-HSA-975144; R-HSA-975155 ) R-HSA-975122 Reaction Name: Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> See in Reactome R-HSA-975139 ( R-HSA-975138; R-HSA-975144; R-HSA-975155 ) R-HSA-975139 Reaction Name: IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation See in Reactome R-HSA-975142 ( R-HSA-975138; R-HSA-975144; R-HSA-975155 ) R-HSA-975142 Reaction Name: Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation See in Reactome R-HSA-975147 ( R-HSA-975138; R-HSA-975155; R-HSA-975163 ) R-HSA-975147 Reaction Name: Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane See in Reactome R-HSA-975185 ( R-HSA-975138; R-HSA-975155; R-HSA-975163 ) R-HSA-975185 Reaction Name: IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments See in Reactome R-HSA-975188 ( R-HSA-975110; R-HSA-975155 ) R-HSA-975188 Reaction Name: TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation See in Reactome R-HSA-975857 ( R-HSA-975871 ) R-HSA-975857 Reaction Name: TRAF6 binds to hp- IRAK1 or p-IRAK2 See in Reactome R-HSA-975879 ( R-HSA-975871 ) R-HSA-975879 Reaction Name: Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex See in Reactome
MONDO:0030924	PSMB10	P40306	3.4.25.1	R-HSA-8951664 R-HSA-8951664 Reactome Name: Neddylation See in Reactome R-HSA-4608870 R-HSA-4608870 Reactome Name: Asymmetric localization of PCP proteins See in Reactome R-HSA-2467813 R-HSA-2467813 Reactome Name: Separation of Sister Chromatids See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-8852276 R-HSA-8852276 Reactome Name: The role of GTSE1 in G2/M progression after G2 checkpoint See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome R-HSA-174184 R-HSA-174184 Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A See in Reactome R-HSA-69017 R-HSA-69017 Reactome Name: CDK-mediated phosphorylation and removal of Cdc6 See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-187577 R-HSA-187577 Reactome Name: SCF(Skp2)-mediated degradation of p27/p21 See in Reactome R-HSA-1236978 R-HSA-1236978 Reactome Name: Cross-presentation of soluble exogenous antigens (endosomes) See in Reactome R-HSA-5610780 R-HSA-5610780 Reactome Name: Degradation of GLI1 by the proteasome See in Reactome R-HSA-5610785 R-HSA-5610785 Reactome Name: GLI3 is processed to GLI3R by the proteasome See in Reactome R-HSA-8854050 R-HSA-8854050 Reactome Name: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis See in Reactome R-HSA-69601 R-HSA-69601 Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A See in Reactome R-HSA-1236974 R-HSA-1236974 Reactome Name: ER-Phagosome pathway See in Reactome R-HSA-5610783 R-HSA-5610783 Reactome Name: Degradation of GLI2 by the proteasome See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-5668541 R-HSA-5668541 Reactome Name: TNFR2 non-canonical NF-kB pathway See in Reactome R-HSA-1169091 R-HSA-1169091 Reactome Name: Activation of NF-kappaB in B cells See in Reactome R-HSA-4641258 R-HSA-4641258 Reactome Name: Degradation of DVL See in Reactome R-HSA-9010553 R-HSA-9010553 Reactome Name: Regulation of expression of SLITs and ROBOs See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-450408 R-HSA-450408 Reactome Name: AUF1 (hnRNP D0) binds and destabilizes mRNA See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-5676590 R-HSA-5676590 Reactome Name: NIK-->noncanonical NF-kB signaling See in Reactome R-HSA-1234176 R-HSA-1234176 Reactome Name: Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha See in Reactome R-HSA-211733 R-HSA-211733 Reactome Name: Regulation of activated PAK-2p34 by proteasome mediated degradation See in Reactome R-HSA-4641257 R-HSA-4641257 Reactome Name: Degradation of AXIN See in Reactome R-HSA-5607761 R-HSA-5607761 Reactome Name: Dectin-1 mediated noncanonical NF-kB signaling See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-8939236 R-HSA-8939236 Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs See in Reactome R-HSA-174178 R-HSA-174178 Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 See in Reactome R-HSA-8939902 R-HSA-8939902 Reactome Name: Regulation of RUNX2 expression and activity See in Reactome R-HSA-349425 R-HSA-349425 Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1 See in Reactome R-HSA-68949 R-HSA-68949 Reactome Name: Orc1 removal from chromatin See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-174154 R-HSA-174154 Reactome Name: APC/C:Cdc20 mediated degradation of Securin See in Reactome R-HSA-195253 R-HSA-195253 Reactome Name: Degradation of beta-catenin by the destruction complex See in Reactome R-HSA-174084 R-HSA-174084 Reactome Name: Autodegradation of Cdh1 by Cdh1:APC/C See in Reactome R-HSA-174113 R-HSA-174113 Reactome Name: SCF-beta-TrCP mediated degradation of Emi1 See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-350562 R-HSA-350562 Reactome Name: Regulation of ornithine decarboxylase (ODC) See in Reactome R-HSA-5632684 R-HSA-5632684 Reactome Name: Hedgehog 'on' state See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-75815 R-HSA-75815 Reactome Name: Ubiquitin-dependent degradation of Cyclin D See in Reactome R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-2871837 R-HSA-2871837 Reactome Name: FCERI mediated NF-kB activation See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-174143 R-HSA-174143 Reactome Name: APC/C-mediated degradation of cell cycle proteins See in Reactome R-HSA-69052 R-HSA-69052 Reactome Name: Switching of origins to a post-replicative state See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-1234174 R-HSA-1234174 Reactome Name: Cellular response to hypoxia See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-69541 R-HSA-69541 Reactome Name: Stabilization of p53 See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-179419 R-HSA-179419 Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint See in Reactome R-HSA-69580 R-HSA-69580 Reactome Name: p53-Dependent G1/S DNA damage checkpoint See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-176408 R-HSA-176408 Reactome Name: Regulation of APC/C activators between G1/S and early anaphase See in Reactome R-HSA-176409 R-HSA-176409 Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins See in Reactome R-HSA-169911 R-HSA-169911 Reactome Name: Regulation of Apoptosis See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-453276 R-HSA-453276 Reactome Name: Regulation of mitotic cell cycle See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-69563 R-HSA-69563 Reactome Name: p53-Dependent G1 DNA Damage Response See in Reactome R-HSA-176814 R-HSA-176814 Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-351202 R-HSA-351202 Reactome Name: Metabolism of polyamines See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-69615 R-HSA-69615 Reactome Name: G1/S DNA Damage Checkpoints See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69610 R-HSA-69610 Reactome Name: p53-Independent DNA Damage Response See in Reactome R-HSA-69613 R-HSA-69613 Reactome Name: p53-Independent G1/S DNA damage checkpoint See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome	Cellular responses to stimuli Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Transport of small molecules Metabolism of RNA Metabolism of proteins DNA Replication Signal Transduction	R-HSA-1168640 ( R-HSA-1169091 ) R-HSA-1168640 Reaction Name: Ubiquitinated IkB is degraded See in Reactome R-HSA-1234159 ( R-HSA-1234176 ) R-HSA-1234159 Reaction Name: Proteasome proteolyzes ub-HIF-alpha See in Reactome R-HSA-1236935 ( R-HSA-1236974 ) R-HSA-1236935 Reaction Name: Proteasomal cleavage of substrate See in Reactome R-HSA-1236970 ( R-HSA-1236978 ) R-HSA-1236970 Reaction Name: Proteasomal clevage of exogenous antigen See in Reactome R-HSA-1504193 ( R-HSA-4641258 ) R-HSA-1504193 Reaction Name: Ubiquitinated DVL is degraded by the proteasome See in Reactome R-HSA-174058 ( R-HSA-174084 ) R-HSA-174058 Reaction Name: Degradation of multiubiquitinated Cdh1 See in Reactome R-HSA-174105 ( R-HSA-174178 ) R-HSA-174105 Reaction Name: Degradation of multiubiquitinated cell cycle proteins See in Reactome R-HSA-174202 ( R-HSA-174154; R-HSA-2467813 ) R-HSA-174202 Reaction Name: Degradation of multiubiquitinated Securin See in Reactome R-HSA-174203 ( R-HSA-174113 ) R-HSA-174203 Reaction Name: SCF-mediated degradation of Emi1 See in Reactome R-HSA-174255 ( R-HSA-174184 ) R-HSA-174255 Reaction Name: Degradation multiubiquitinated Cyclin A See in Reactome R-HSA-187574 ( R-HSA-187577 ) R-HSA-187574 Reaction Name: Degradation of ubiquitinated p27/p21 by the 26S proteasome See in Reactome R-HSA-188191 ( R-HSA-174178 ) R-HSA-188191 Reaction Name: APC/C:Cdh1-mediated degradation of Skp2 See in Reactome R-HSA-209061 ( R-HSA-9020702 ) R-HSA-209061 Reaction Name: Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex See in Reactome R-HSA-211715 ( R-HSA-211733 ) R-HSA-211715 Reaction Name: Proteasome mediated degradation of PAK-2p34 See in Reactome R-HSA-2130282 ( R-HSA-195253 ) R-HSA-2130282 Reaction Name: Degradation of ubiquitinated beta catenin by the proteasome See in Reactome R-HSA-264458 ( R-HSA-349425 ) R-HSA-264458 Reaction Name: Proteasome mediated degradation of COP1 See in Reactome R-HSA-353125 ( R-HSA-350562 ) R-HSA-353125 Reaction Name: 26S proteosome degrades ODC holoenzyme complex See in Reactome R-HSA-3640874 ( R-HSA-4641257 ) R-HSA-3640874 Reaction Name: Ub-RibC-AXIN is degraded by the proteasome See in Reactome R-HSA-450466 ( R-HSA-450408 ) R-HSA-450466 Reaction Name: AUF1:mRNA complex is destroyed See in Reactome R-HSA-4608855 ( R-HSA-4608870 ) R-HSA-4608855 Reaction Name: PRICKLE1 is degraded by the proteasome See in Reactome R-HSA-4641256 ( R-HSA-4641257 ) R-HSA-4641256 Reaction Name: Ubiquitinated AXIN is degraded by the proteasome See in Reactome R-HSA-4641260 ( R-HSA-4641258 ) R-HSA-4641260 Reaction Name: Ubiquitinated DVL1 is degraded by the proteasome See in Reactome R-HSA-5362448 ( R-HSA-5358346 ) R-HSA-5362448 Reaction Name: Hh C-terminal fragments are degraded by the proteasome See in Reactome R-HSA-5607724 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-5607724 Reaction Name: 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex See in Reactome R-HSA-5607731 ( R-HSA-5607761; R-HSA-5607764; R-HSA-5668541; R-HSA-5676590 ) R-HSA-5607731 Reaction Name: 26S proteasome processes p-7S-p100:RELB to form p52:RELB See in Reactome R-HSA-5610754 ( R-HSA-5610785 ) R-HSA-5610754 Reaction Name: GLI3 is partially degraded by the proteasome to yield the GLI3 repressor See in Reactome R-HSA-5610757 ( R-HSA-5610783 ) R-HSA-5610757 Reaction Name: GLI2 is degraded by the proteasome See in Reactome R-HSA-5610758 ( R-HSA-5610780 ) R-HSA-5610758 Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP See in Reactome R-HSA-5610760 ( R-HSA-5610780 ) R-HSA-5610760 Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by ITCH See in Reactome R-HSA-5635854 ( R-HSA-5632684 ) R-HSA-5635854 Reaction Name: GLI2,3 are degraded by the proteasome See in Reactome R-HSA-5635868 ( R-HSA-5632684 ) R-HSA-5635868 Reaction Name: ub-GLI is degraded by the proteasome See in Reactome R-HSA-5658430 ( R-HSA-5658442 ) R-HSA-5658430 Reaction Name: NF1 is degraded by the proteasome See in Reactome R-HSA-5665854 ( R-HSA-5689603 ) R-HSA-5665854 Reaction Name: ADRM1:26S proteaseome binds UCHL5 See in Reactome R-HSA-5665871 ( R-HSA-5689603 ) R-HSA-5665871 Reaction Name: ADRM1 binds 26S proteasome See in Reactome R-HSA-5668481 ( R-HSA-5668541 ) R-HSA-5668481 Reaction Name: Protesomal degradation of K48polyUb-TRAF3 See in Reactome R-HSA-5668520 ( R-HSA-5668541 ) R-HSA-5668520 Reaction Name: 26Sproteasome degrades K48polyUb-NIK See in Reactome R-HSA-5687112 ( R-HSA-5687128 ) R-HSA-5687112 Reaction Name: MAPK6 is degraded by the 26S proteasome See in Reactome R-HSA-5689539 ( R-HSA-5689880 ) R-HSA-5689539 Reaction Name: ADRM1:26S proteaseome binds USP14 See in Reactome R-HSA-68825 () R-HSA-68825 Reaction Name: Ubiquitinated geminin is degraded by the proteasome See in Reactome R-HSA-68948 ( R-HSA-68949 ) R-HSA-68948 Reaction Name: Ubiquitinated Orc1 is degraded by the proteasome See in Reactome R-HSA-69016 ( R-HSA-69017 ) R-HSA-69016 Reaction Name: Ubiquitinated Cdc6 is degraded by the proteasome See in Reactome R-HSA-69600 ( R-HSA-69601 ) R-HSA-69600 Reaction Name: Proteolytic degradation of ubiquitinated-Cdc25A See in Reactome R-HSA-75825 ( R-HSA-75815 ) R-HSA-75825 Reaction Name: Proteasome mediated degradation of Cyclin D1 See in Reactome R-HSA-8850992 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8852354 ( R-HSA-69481; R-HSA-8852276 ) R-HSA-8852354 Reaction Name: GTSE1 facilitates proteasome-mediated degradation of TP53 See in Reactome R-HSA-8854044 ( R-HSA-8854050 ) R-HSA-8854044 Reaction Name: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 See in Reactome R-HSA-8854071 ( R-HSA-8854050 ) R-HSA-8854071 Reaction Name: Proteasome-mediated degradation of PolyUb-FBXL7 See in Reactome R-HSA-8866553 ( R-HSA-382556 ) R-HSA-8866553 Reaction Name: misfolded CFTR is degraded by the 26S proteasome See in Reactome R-HSA-8932355 ( R-HSA-8951664 ) R-HSA-8932355 Reaction Name: 26S proteasome degrades Ub-NFE2L2 See in Reactome R-HSA-8939801 ( R-HSA-8939902 ) R-HSA-8939801 Reaction Name: 26S proteasome degrades PolyUb-RUNX2 See in Reactome R-HSA-8952408 ( R-HSA-8941858 ) R-HSA-8952408 Reaction Name: Polyubiquitinated RUNX3 is degraded by the proteasome See in Reactome R-HSA-8956140 ( R-HSA-8951664 ) R-HSA-8956140 Reaction Name: NEDD8 and UBD bind NUB1 and the 26S proteasome See in Reactome R-HSA-8956184 ( R-HSA-8951664 ) R-HSA-8956184 Reaction Name: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates See in Reactome R-HSA-8957265 ( R-HSA-8939236 ) R-HSA-8957265 Reaction Name: 26S proteasome degrades TP73 polyubiquitinated by ITCH See in Reactome R-HSA-9008110 ( R-HSA-8939902 ) R-HSA-9008110 Reaction Name: Proteasome degrades polyubiquitinated RUNX2 See in Reactome R-HSA-9008475 ( R-HSA-8939902 ) R-HSA-9008475 Reaction Name: Proteasome degrades polyubiquitinated RUNX2 See in Reactome R-HSA-9009362 ( R-HSA-8939902 ) R-HSA-9009362 Reaction Name: Proteasome degrades PolyUb-RUNX2 See in Reactome R-HSA-9011313 ( R-HSA-9010553 ) R-HSA-9011313 Reaction Name: Proteasome degrades ubiquitinated ROBO3.1 See in Reactome R-HSA-9604642 ( R-HSA-9604323 ) R-HSA-9604642 Reaction Name: Proteasome degrades ubiquitinated NICD4 See in Reactome R-HSA-9755303 ( R-HSA-8951664 ) R-HSA-9755303 Reaction Name: 26S proteasome degrades HIFalpha See in Reactome R-HSA-9755306 ( R-HSA-8951664 ) R-HSA-9755306 Reaction Name: ub UBXN7 is degraded by the 26S proteasome See in Reactome R-HSA-9762096 () R-HSA-9762096 Reaction Name: Ub,pS335,S338,T NFE2L2 is degraded See in Reactome R-HSA-983150 ( R-HSA-983168 ) R-HSA-983150 Reaction Name: Proteasomal cleavage of substrate See in Reactome
MONDO:0032599	IKBKB	O14920	2.7.11.10 2.7.11.1	R-HSA-5684264 R-HSA-5684264 Reactome Name: MAP3K8 (TPL2)-dependent MAPK1/3 activation See in Reactome R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-937039 R-HSA-937039 Reactome Name: IRAK1 recruits IKK complex See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-937041 R-HSA-937041 Reactome Name: IKK complex recruitment mediated by RIP1 See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-1236974 R-HSA-1236974 Reactome Name: ER-Phagosome pathway See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome R-HSA-975144 R-HSA-975144 Reactome Name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation See in Reactome R-HSA-445989 R-HSA-445989 Reactome Name: TAK1-dependent IKK and NF-kappa-B activation See in Reactome R-HSA-5357956 R-HSA-5357956 Reactome Name: TNFR1-induced NFkappaB signaling pathway See in Reactome R-HSA-1810476 R-HSA-1810476 Reactome Name: RIP-mediated NFkB activation via ZBP1 See in Reactome R-HSA-209543 R-HSA-209543 Reactome Name: p75NTR recruits signalling complexes See in Reactome R-HSA-209560 R-HSA-209560 Reactome Name: NF-kB is activated and signals survival See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-1169091 R-HSA-1169091 Reactome Name: Activation of NF-kappaB in B cells See in Reactome R-HSA-168927 R-HSA-168927 Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment See in Reactome R-HSA-2871837 R-HSA-2871837 Reactome Name: FCERI mediated NF-kB activation See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1606322 R-HSA-1606322 Reactome Name: ZBP1(DAI) mediated induction of type I IFNs See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-193639 R-HSA-193639 Reactome Name: p75NTR signals via NF-kB See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome	Immune System Signal Transduction	R-HSA-1168637 ( R-HSA-1169091 ) R-HSA-1168637 Reaction Name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK See in Reactome R-HSA-1168638 ( R-HSA-1169091 ) R-HSA-1168638 Reaction Name: Activated IKK phosphorylates I-kappaB See in Reactome R-HSA-1168641 ( R-HSA-1169091 ) R-HSA-1168641 Reaction Name: TAK1 associated with the CBM complex phosphorylates IKKbeta See in Reactome R-HSA-168140 ( R-HSA-166058; R-HSA-1810476; R-HSA-445989; R-HSA-9020702; R-HSA-933542; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-168140 Reaction Name: Active IKK Complex phosphorylates NF-kappa-B inhibitor See in Reactome R-HSA-168184 ( R-HSA-166058; R-HSA-168638; R-HSA-445989; R-HSA-9020702; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-168184 Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex See in Reactome R-HSA-168910 ( R-HSA-1810476 ) R-HSA-168910 Reaction Name: RIP1 facilitates IKK complex phosphorylation See in Reactome R-HSA-193641 ( R-HSA-209543 ) R-HSA-193641 Reaction Name: IKK-beta is recruited See in Reactome R-HSA-193703 ( R-HSA-209560 ) R-HSA-193703 Reaction Name: IKKbeta is activated See in Reactome R-HSA-193705 ( R-HSA-209560 ) R-HSA-193705 Reaction Name: IKKbeta phosphorylates IkB causing NF-kB to dissociate See in Reactome R-HSA-202500 ( R-HSA-202424 ) R-HSA-202500 Reaction Name: Activation of IKK complex See in Reactome R-HSA-202534 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-202534 Reaction Name: Ubiquitination of NEMO by TRAF6 See in Reactome R-HSA-202541 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-202541 Reaction Name: p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB See in Reactome R-HSA-209087 ( R-HSA-9020702 ) R-HSA-209087 Reaction Name: IKBA is phosphorylated by Phospho IKKB kinase See in Reactome R-HSA-2730876 ( R-HSA-2871837 ) R-HSA-2730876 Reaction Name: Phosphorylation of IKK-beta by TAK1 See in Reactome R-HSA-451561 ( R-HSA-9020702 ) R-HSA-451561 Reaction Name: NEMO binds polyubiquitinated IRAK1 See in Reactome R-HSA-5357776 ( R-HSA-5357956 ) R-HSA-5357776 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG See in Reactome R-HSA-5357831 ( R-HSA-5357905 ) R-HSA-5357831 Reaction Name: CYLD is phosphorylated by IKK See in Reactome R-HSA-5607742 ( R-HSA-5607764 ) R-HSA-5607742 Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta See in Reactome R-HSA-5609665 ( R-HSA-166058; R-HSA-445989; R-HSA-9020702; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-5609665 Reaction Name: CHUK, IKBKB and IKBKG form IKK complex See in Reactome R-HSA-5626962 ( R-HSA-5357905 ) R-HSA-5626962 Reaction Name: GNB2L1 binds IKKA:IKKB:NEMO See in Reactome R-HSA-5684267 ( R-HSA-166058; R-HSA-5684264; R-HSA-9020702; R-HSA-975138; R-HSA-975155; R-HSA-975871 ) R-HSA-5684267 Reaction Name: IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex See in Reactome R-HSA-5684275 ( R-HSA-166058; R-HSA-5684264; R-HSA-9020702; R-HSA-975138; R-HSA-975155;